Method of diagnosing functional interhemispheric asymmetry in right-handed and left-handed people

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to field of medical and psychophysiological diagnostics. Assessment of character of motor asymmetries - determination of degree of right-handedness - left-handedness by dominance of hand and leg, as well as sensor asymmetries - determination of leading eye and ear, is performed. Also calculated is coefficient of amplitude and frequency of mu-rhythm in central parts of left and right hemisphere, as ratio of difference of maximal and minimal values to their sum. Difference between maximal and minimal values is calculated within 3-second long interval. Dominating hemisphere of motor cortex by mu-rhythm is registered at the moment of alternate clenching right and left hand fist with application of sensomotor test by scheme: "Close eyes - make right fist - open eyes - undo the fist", "Close eyes - make left fist - open eyes - then undo the fist', during standard registration of electroencephalogram.

EFFECT: method extends arsenal of means for assessment of functional interhemispheric asymmetry.

9 dwg, 4 tbl, 2 ex

 

The invention relates to medicine, in particular to the field of medical and psycho-physiological diagnostics, and for diagnosing the degree of functional asymmetry in right-handers and left-handers.

Hemispheric asymmetry is a fundamental property of the human brain. The first modern statement of the problem of functional interhemispheric asymmetry (VMA) the man appeared after work Rugosa (1861), W.Ogle (1867), K.Wemicke (1874), H.Bastian (1882) and others, showed a lateralization of speech functions in humans.

Studies on the assessment of the severity of sensory and motor asymmetries in groups of left-handed and right-handed, different methods of determination of functional asymmetry (Annet M. The distribution of manual asymmetry // Br. J. O Psychology. 1972. V.6. P.343-358; Fedoruk A.G., Dobrokhotova T.A. Functional asymmetry of human rights in operator activity. // Space biology and aerospace medicine. - 1980. No. 5. - P.39-42; Fomina E.V. Sensorimotor asymmetry athletes. - Omsk, 2003. - P.150; Bragin N.N., Dobrokhotova T.A. Functional asymmetry of man, 2nd ed. - M.: Medicine, 1988. - S-219). Measured using different tests functional brain asymmetry speaks only about the specific behavioral manifestations and does not always correlate with the total functional asymmetry.

The use of electroencephalography (EEG) in the analysis MIP locarnos asymmetry significantly complements the overall picture of the differences between right and left handers. Hemispheric differences coherent characteristics of EEG in right-handers and left-handers, described by various researchers, by nature heterogeneous and contradictory, have different methodological approaches (Grindel O.M., O., Sazonova, Fat D.B Study of the spatial structure of the alpha rhythm of a healthy person by the method of mapping of EEG. // Ukr. the Supreme. nerve. activities. - V.42. - B.2. - 1992. - S-499; Goldstein L. differential hemispheric EEG activation in the right - and left-handed. Left-handedness, anthropometry and lateral adaptation. - Moscow - Voroshilovgrad, 1985. - P.41; Dobrokhotova T.A., N. Bragin. Left-handers. - M.: Medicine, 1977. - S; Efimov, I., Temaeva M.A., Uvarov L.G. Hemispheric asymmetry (MPas) ranges of EEG rhythms and evidence of variability in healthy people, depending on the lateralization dominant hand. // Human physiology. - 1984. - V.10. No. 4. - S; Zhavoronkova L.A. Right-handed-left-handed: interhemispheric asymmetry of the bioelectric potentials of the human brain. - Krasnodar: Ecoinvent, 2009. - P.21-64; Rusyns B.C., Grendel O.M., Boldyreva G.N., Waqar E.M. Symmetry and stability of the spectra of the EEG of a healthy person. // Ukr. the Supreme. a nerve. activities. - 1976. - T. No. 3. - S-587; Rusyns B.C., Grendel O.M., Boldyreva G.N., Waqar EM. the Bioelectric potentials of the human brain (mathematical analysis). - M.: Medicine, 1987. - S; Yoshii F., Ginsberg M.D., R.E. Kelley et al. Asymmetric somatosensory activation topographic study // Brai Res. 1989. V.48. No. 2. - P.355; Lopez da Silva F.N., Van Lierop T.N., Schrijer C.F., Storm van Leeuwen, W. organization of thalamic and cortical alpha rhythms: spectra and coherences / EEG and din. Neurophysiol. 1973. V.35. P.627; J.B. Earle Task difficulty and EEG alpha asymmetry: an amplitude and frequency analysis // Neuropsychobiology. 1988. V.20, P.96-112).

In the laboratory of clinical neurophysiology at the Institute of neurosurgery named after. NEC developed a method of estimating frequency characteristics of EEG using the average frequency and the effective frequency band of the power spectrum. However, the analysis of biorhythms in this way, the groups of left-handed and right-handed was not found statistically significant hemispheric differences, they are only in the range of the alpha rhythm frequency in right-handers (Grindel O.M., Gershman YEAR, Boldyreva GN. and other Mercantile relations in the cerebral cortex of the human brain according to the spectrum, coherence and phase spectrum of the EEG, Zh. the Supreme. a nerve. activities. - 1973. - E. No. 4. - S-781). According to S.R. Butler (Butler S.R., A. Glass Asymmetries in the encephalogramm associated with cerebral dominance // EEG and din. Neurophysiol. 1978. V.45. No. 4. - P.393). Currently, there are many ways to determine hemispheric asymmetry (patent RU №2115364, 20.07.1998; RU patent No. 2151548, 27.06.2000; RU patent No. 2198589, 20.02.2003). However, most of them are related to the determination of hemispheric asymmetry using sensory and motor samples without analysis of the electrophysiological pattern of the brain hemispheres.

There is a way to determine the degree between Rosarno brain asymmetry (application RU # 2003135904, CL A61B 5/16, bull. No. 14, 2005), where as an indicator of the functional state of the brain is used, the level of functionality of the Central nervous system (UVB CNS). Sensorimotor test perform unimanual with a pause of not less than 7 minutes. The hemispheric asymmetry coefficient calculated by the formula:

CAS=(Upwl-Upwp)/(Wfwl+Upwp)·100%, where Ufwl is the level of functionality of the nervous system when performing sensorimotor test right hand; Upwp is the level of functionality when performing sensorimotor test with the left hand. The disadvantage of this method is the lack of data about the reaction of the biological rhythms of the brain by EEG in the time of the sensorimotor test.

There is a method of determining the functional condition of the person with the right profile asymmetry (Zhavoronkova L.A. AC No. 1581278, 30.07.1990), which is later supplemented by the results of a detailed analysis of brain biorhythms in wakefulness and in sleep in right-handers and left-handers with the implementation of the programme coherent analysis (CA) rhythms in hemispheres:

Ka=1/n(When E is C1 - COH E P1/Coherent E H1 + COH E P1+ ...+COH E PL - COH E PP/Coherent E PL+COH E PP), where Coherence - coherence, E - sum, L - left, P - right (Zhavoronkova L.A. Right-handed-left-handed: interhemispheric asymmetry of the bioelectric potentials of the human brain. - Krasnodar: Ecoinvent, 2009. - P.21-64). However, no data concerning analysis of mu-ri is mA (romanticheskogo, somatosensory), which is a variant of the normal rhythm, similar in frequency response to alpha rhythm, but differing from it by the severity in different areas of the cortex (mu rhythm is recorded mainly in the Central regions).

There is a method of determining the individual profile of the lateral organization (PLO) (Bragin N.N., Dobrokhotova T.A. Functional asymmetry of human rights. - M.: Medicine, - 1988. - S-219)adopted for the prototype, including the assessment of the nature of motor asymmetries - determination of the degree of prevesta-levesta motor dominance hands and feet (figure 1), as well as sensory asymmetries - the definition of the leading eye and ear. However, as described in the prototype method of determining hemispheric asymmetry using sensory and motor tests does not reflect the complete picture of functional hemispheric asymmetry, as it contains the analysis of the electrophysiological pattern of the brain hemispheres.

The task of the invention is to identify reliable criteria for determining functional hemispheric asymmetry in left-handers and right-handed use registration mu-rhythm on EEG in different functional States of wakefulness and definitions bioelectric focus domination mu-rhythm in hemispheres using sensorimotor tests.

Task d is moved through the implementation of the method of determining the individual profile of the lateral organization using the mu-rhythm, registered through electroencephalogram (EEG) in different functional States of wakefulness and sensorimotor test for right and left hand.

To accomplish the objectives of the research was conducted in the city of Vladivostok on the basis of the Medical center "NEURON" in the past 12 months (in 2009 and 2010). For examination of selected healthy volunteers of both sexes 260 people aged 20-40 years. Age group selected taking into account the age of maturity and stability rhythms on EEG, but also due to the lack of chronic diseases in the study group. Dynamic testing of patients was carried out at the same time of the day (from 10 to 12 hours). The definition of individual lateral profile of the organization (PLO) (right-handed or left-handed) was carried out according to the method (Bragin N.N., Dobrokhotova T.A., 1988), volunteers with mixed type of PLO were excluded. Next were recording EEG with functional tests with the addition of sensorimotor tests. The EEG recording was performed in the sitting position in a darkened room by standard methods, including passive and active wakefulness, functional tests (opening-closing eyes, rhythmic photostimulation 2-30 Hz (RFU) and hyperventilation (GW) 5 min). Used the layout of electrodes on International the th system "10-20" (Jasper, 1958) in standard leads, including the main areas of the brain, the left and right hemispheres: the occipital (O), parietal (P), Central (C), frontal (F), temporal (T). Used monopolar combined with a reference electrode and bipolar montages. Bandwidth of 0.5-35 Hz, amplitude calibration 7 µv, pitch 30 mm/sec. Using the frequency and amplitude analysis was determined region of dominance in the range of mu-rhythm hemispheric building potential maps activity and their potential fields. All indicators were calculated separately for the right and left hemisphere.

During the detailed analysis of the mu-rhythm on EEG were observed best visualization of the mu-rhythm in bipolar montage in the Central-parietal, and when monopolar montage - in the Central departments. The differences for the left-handed and right-handed in the localization of the dominant functional focus mu-rhythm of the hemispheres with the inverse dependence of the prevalence of mu rhythm during sensorimotor samples from the dominant hand.

With the help of the results obtained was formed a new method for the diagnosis of functional hemispheric asymmetry in right-handers and left-handers, which is the definition of individual lateral profile of the organization (PLO) using mu-rhythm on EEG in different functional States of wakefulness (with the amplitudes of the on-frequency analysis of asymmetry) and sensorimotor breakdown according to the scheme: "Close my eyes squeeze the right hand to open the eyes and then close his hand"; "Close my eyes squeeze his left hand to open the eyes and then close his hand."

The method is as follows.

First, conduct individual testing, including determination of the individual lateral profile of the organization, assess the nature of motor asymmetries - determination of the degree of prevesta-levesta the dominance of the hands and feet, as well as sensory asymmetries with the definition of the leading eye and ear. Then make a routine EEG recording (in sitting position) in a darkened room by standard methods, including passive and active wakefulness, functional tests (opening-closing eyes, rhythmic photostimulation 2-3 0 Hz (RFU) and hyperventilation (GW) 5 minutes). Applies arrangement of electrodes according to the International system "10-20" (Jasper, 1958) in standard leads with the inclusion of the main areas of the brain, the left and right hemispheres. Used monopolar combined with a reference electrode and bipolar montages. Bandwidth of 0.5-35 Hz, amplitude calibration 7 µv, pitch 30 mm/sec. The analysis focuses on bitartarate EEG segments with a fixed period in 3 seconds plots with the best visualization of the mu-rhythm in the Central and Central-parietal leads (With-R). All indicators are calculated separately on the I'm right and left hemisphere. Then determine the bioelectrical functional focus domination mu-rhythm in hemispheres during sensorimotor tests carried out according to the scheme: "Close my eyes squeeze the right hand to open the eyes and then close his hand"; "Close my eyes squeeze his left hand to open the eyes and then close his hand."

For the analysis of mu-rhythm developed amplitude-frequency asymmetry parameters.

The ratio of the amplitude asymmetry is calculated by the formula:

KAA=(R(Nmax-Nmin)l-R(Nmax-Nmin)p)/(R(Nmax-Nmin)l+R(Nmax-Nmin)p)×100%,

where KAA - factor amplitude asymmetry, R=Nmax-Nmin - the difference between the maximum (Nmax) and minimum (Nmin) points inside the interval in the Central leads for 3 seconds; l - left p - right hemisphere.

The frequency coefficient of skewness is calculated by the formula:

CCA=(R (Nmax-Nmin)l-R (Nmax-Nmin)p)/(R (Nmax-Nmin)l+R (Nmax-Nmin)p)×100%;

where CCA - frequency coefficient of asymmetry, R=Nmax-Nmin - the difference between the maximum (Nmax) and minimum (Nmin) points inside the interval in the Central leads for 3 seconds; l - left p - right hemisphere.

The method is illustrated to illustrate the material, where

figure 1 shows a diagram of the projection of the sensorimotor region of the right and left hands;

figure 2 and 3 shows a portion of an electroencephalogram C., 30 years (right-handed) (bipolar montage), with analysis of the difference in the spectrogram between mu-rhythm and alpha rhythm (μv;

figure 4 and 5 shows a portion of an electroencephalogram C., 30 years (right-handed) (monopolar montage), identifying focus domination mu-rhythm on the cartogram during sensorimotor tests (µv);

figure 6 and 7 shows a portion of an electroencephalogram K., 30 years (left-handed) (bipolar montage), with analysis of the difference in the spectrogram between mu-rhythm and alpha rhythm (µv);

on Fig and 9 shows a fragment of the electroencephalogram K., 30 years (left-handed) (monopolar montage), identifying focus domination mu-rhythm on the cartogram during sensorimotor tests (MACs).

The method is illustrated by the following examples.

As an example, two volunteers (without organic brain disease) right-handed and left-handed single age male. Determined individual lateral profile of the organization with carrying out the electroencephalogram in different functional States of wakefulness and sensorimotor sample is amplitude-frequency analysis of the mu-rhythm in comparison with cortical rhythm (alpha rhythm) in different areas of the brain.

Example 1: S, 30 years (right-handed).

Volunteer With. (male 30 years), testing PLO - right-handed (leading eye - right, leading ear - right, leading hand - the right leading leg - right).

In tables 1 and 2 presents a comparative analysis of the average values of the amplitudes and frequencies of the mu and alpha rhythm in different areas of the brain, indicates the presence of patterns in the hemispheric distribution of mu and alpha rhythms depending on the dominant hemisphere.

Table 1
Comparative analysis of average values of the amplitudes and the frequency of mu and alpha rhythms in different areas of the brain in right-handers (C. 30) (µv)
The projection area of the brainMu rhythmAlpha rhythm
Left (1)Right (2)Left (1)Right (2)
Central and parietal-Central leads (C, C-P) (µv)5042,3--
Occipital and parieto-occipital leads (O, P-O) (µv)23,318

Table 2
Comparative analysis is one of the values of the amplitudes and the frequency of mu and alpha rhythms in different areas of the brain in right-handers (C. 30 years) (µv)
The projection area of the brainMu rhythmAlpha rhythm
Left (1)Right (2)Left (1)Right (2)
Central and parietal-Central leads (C, C-P) (Hz)11,110--
Occipital and parieto-occipital leads (O, P-O) (Hz)--9,88,5

Conducted spectral analysis of the mu-rhythm in comparison with the alpha-rhythm in the flat areas of hemispheric dominance (table 1, 2 and figure 2, 3). According to EEG revealed the difference in the amplitude-frequency dominance of the mu-rhythm of the hemispheres. Identified similarities in the frequency-amplitude dominance of the mu-rhythm and the alpha rhythm in the left hemisphere. However, there are differences in the mu rhythm and the alpha rhythm: mu rhythm is better visualized in bipolar montage, and the alpha rhythm during monopolar montage; mu rhythm is monopolar installation in the Central regions of the left hemisphere, PR is bipolar montage - in the Central-parietal sections of the left hemisphere, and the alpha rhythm in the occipital region of the left hemisphere. With KAA, CCA revealed the difference in the amplitude and frequency of mu-rhythm in the Central regions (C) right-handed:

1) the amplitude R left 50 µv, R to the right of 42.3 µv

KAA=7,7/92,3×100%=8,3%;

2) frequency R to the left of 11.1 Hz, R right 10 Hz

CCA=1,1/21,1×100%=5,2%.

On the sensorimotor sample - at the time of tightening the right hand there was no complete suppression of the mu rhythm with the subsequent predominance of mu-rhythm in the sensorimotor region of the left hemisphere, which is a reflection of the cortical representation of the function of the right hand.

Example 2: K. 30 years (left-handed).

Volunteer K. (man 30 years), PLO - southpaw (leading eye - left, leading the ear - left, leading hand - the left, the leading foot (left).

In table 3-4 presents a comparative analysis of mean values of amplitude and frequency of mu-rhythm and alpha rhythm in different areas of the brain.

Table 3
Comparative analysis of average values of the amplitudes mu and alpha rhythms in different areas of the brain in left-handers (K. 30 years) (µv)
The projection area of the brainMu rhythm Alpha rhythm
Left (1)Right(2)Left (1)Right(2)
Central and parietal-Central leads (C, C-P) (µv)53,965,3--
Occipital and parieto-occipital leads (O,
P-O) (µv)
-2832

Table 4.
A comparative analysis of the average frequency of mu and alpha rhythms in different areas of the brain in left-handers (K. 30 years) (Hz)
The projection area of the brainMu rhythmAlpha rhythm
Left (1)Right (2)Left (1)Right (2)
Central and parietal-Central leads (C, C-P) (Hz)10,811,4 --
Occipital and parieto-occipital leads (O, P-O) (Hz)--9,310

Conducted spectral analysis of the mu-rhythm in comparison with the alpha-rhythm in the flat areas of hemispheric dominance (table. 3, 4 and Fig. 4, 5). According to EEG revealed the difference in the amplitude-frequency dominance of the mu-rhythm of the hemispheres. Identified similarities in the frequency-amplitude dominance of the mu-rhythm and the alpha rhythm in the right hemisphere. However, identified and differences in mu-rhythm and alpha rhythm: mu rhythm is better visualized in bipolar montage, and the alpha rhythm during monopolar montage; mu rhythm is monopolar installation in the Central regions of the right hemisphere, in bipolar montage - in the Central-parietal sections of the right hemisphere, and the alpha rhythm in the occipital region of the right hemisphere. With KAA, CCA revealed the difference in the amplitude and frequency of mu-rhythm in the Central regions (C) left handed:

1) the amplitude R left 53,9 MACs R right 65,3 MACs

KAA=-11,4/119,2×100%=-9,5%;

2) frequency R from left to 10.8 Hz, R to the right of 11.4 Hz,

CCA=-0,6/22, 2×100%=-2,7%.

On the sensorimotor sample at the time of tightening of the left hand there was no complete suppression of the mu rhythm with the subsequent predominance of mu-rhythm sensomotoric region of the right hemisphere, that is a reflection of the cortical representation of the left hand.

Based on test results (example 1 and 2) the dominance of the mu-rhythm amplitude and frequency, as well as the stability of the sample is observed on the contralateral side in relation to the dominant hemisphere. Right-handed the difference between the maximum and minimum values of mu-rhythm more in the Central regions of the contralateral hemisphere to the left, and the left - handed on the right. The coefficients of asymmetry in the amplitude and frequency of positive right-handed and negative at the left-handers. When the sensorimotor sample (clenching of the hand in a fist) is not a complete suppression of the mu rhythm of the EEG in the Central regions of the contralateral side of the hemisphere in relation to the dominant hand.

Comparative analysis of the prototype shows that to determine the functional hemispheric asymmetry, in addition to the individual profile of the lateral (right-handed left-handed), first use of amplitude-frequency analysis of the mu-rhythm with the calculation of the amplitude and frequency of asymmetry during the recording of the electroencephalogram in different functional States of wakefulness (passive-active wakefulness, photic stimulation, hyperventilation), and to determine the bioelectrical focus domination mu-rhythm in hemispheres is sensomotor the sample according to the scheme: "Close my eyes squeeze the right hand to open the eyes and then close his hand", "Close my eyes squeeze his left hand to open the eyes and then close his hand."

Practical importance of finding the exact criteria of functional hemispheric asymmetry lies in the fact that on this basis, possible earlier diagnosis of incomplete adaptation of the body, a symptom of which is the inversion of hemispheric dominance, which may underlie psychosomatic, neurotic disorders and addictive behaviors. There is evidence of different adaptation strategies people with different profiles of functional hemispheric asymmetry: social stressors seem to tolerate the person with the right and natural - with the left profile; comfortable climatic conditions stereotypical environment the advantage of getting the right individuals, and in extreme constantly changing environments more effective people with left and symmetric profiles (Leucin VP, Nikolaeva, E.I. psycho-Physiological mechanisms of adaptation and functional asymmetry. - Novosibirsk. - Nauka, 1988. - S).

Accurate diagnosis of functional hemispheric asymmetry improves the efficiency of the professional selection of people in different types of employment and sports activities, as well as to develop the best teaching methods and TREN the programme of subjects of educational space, provide individual approach to a specific person.

Method for the diagnosis of functional hemispheric asymmetry in right-handers and left-handers necessary in the study of the biological basis of individual differences between right-handed and left-handed, to determine the role of individual-typological properties in employment, education, sport activity and to estimate prognosis in diseases of the nervous system depending on the dominant hemisphere of the brain.

The method of evaluating functional hemispheric asymmetry in right-handers and left-handers, including the definition of individual lateral profile of the organization: including an assessment of the nature of motor asymmetries - determination of the degree of prevesta-levesta the dominance of the hands and feet, as well as sensory asymmetries - the definition of the leading eye and ear, characterized in that the counting rate asymmetry of the amplitude and frequency of mu-rhythm in the Central parts of the left and right hemisphere according to the formula: KA=R(Nmax-Nmin)l-R (Nmax-Nmin)p)/(R (Nmax-Nmin)l+R (Nmax-Nmin)p)·100%, where KA is the coefficient of skewness, l - the left hemisphere, p - the right hemisphere, R(Nmax-Nmin) is the difference between the maximum and minimum values within the interval duration 3; dominant hemisphere motor cortex on a mu-rhythm recorded at the time sequential compression of the right and left hands in a fist with the use of sensorimotor tests on schemes is: "Close my eyes squeeze the right hand to open the eyes and then close his hand", "Close my eyes squeeze his left hand to open the eyes and then close his hand, during the recording of the electroencephalogram.



 

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1 dwg, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to neurology, immunology and occupational pathology. Rheoencephalography with hypercapnic test are performed, visual evoked potentials (VEP), encephalography (EEG) are registered, level of antibodies to protein S100, level of immunoglobulin G in blood serum are determined. Canonical value is calculated by formula: Cv=3.18-0.38×a1-1.61×a2-0.71×a3+0.93×a4+1.19×a5-0.81×a6, where Cv is canonical value; -0.38; -1.61; -0.71; 0.93; 1.19; -0.81 are discriminant coefficients; 3.18 is constant; a1 is intensity of blood supply in frontomastoid pool during hypercapnic test in ohm; a2 is amplitude of peak N1 of VEP in right occipital lead in mcV; a3 is level of antibodies to protein S100 in conv. units; a4 is level of immunoglobulin G in g/l; a5 is presence or absence of nidus of pathological activity on EEG: 0 - no, 1 - present; a6 is degree of expression of diffuse changes by EEG; 0 - no, 1 - mild, 2 - moderate, 3 - expressed, 4 - severe. If Cv is lower than the constant, early manifestations of chronic mercury intoxication are diagnosed, if Cv is higher or equals the constant, chronic mercury intoxication of the first.

EFFECT: method extends arsenal of means for diagnostics of early manifestations of chronic mercury intoxication.

1 tbl, 3 ex

FIELD: medicine, neurology, psychopathology, neurosurgery, neurophysiology, experimental neurobiology.

SUBSTANCE: one should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another.

EFFECT: higher accuracy of diagnostics.

5 dwg, 1 ex, 1 tbl

FIELD: medicine, neurology.

SUBSTANCE: one should establish neurological status, bioelectric cerebral activity, availability of perinatal and ORL pathology in patients, establish their gradations and numerical values followed by calculation of prognostic coefficients F1 and F2 by the following formulas: F1=-31,42+1,49·a1-2,44·a2+0,2·а3+1,63·a4+0,62·а5+3,75·a6+1,8·а7-3,23·a8-0,8·а9-1,32·а10+3,26·а11+8,92·a12-2,0·a13+3,88·а14+1,79·a15+0,83·a16-2,78·a17; F2=-27,58+1,43·a1+3,31·а2+0,08·а3+3,05·а4-0,27·а5+2,69·а6+3,11·а7-6,47·a8-6,55·a9+1,99·а10+5,25·а11+7,07·a12-0,47·a13+0,13·a14+4,04·a15-1,0·a16-1,14·а17, correspondingly, where a1 - patient's age, a2 - studying either at the hospital or polyclinic, a3 - duration of stationary treatment (in days), a4 - unconscious period, a5 - terms of hospitalization since the moment of light close craniocerebral trauma, a6 - smoking, a7 - alcohol misuse, a8 - arterial hypertension, a9 - amnesia, a10 - close craniocerebral trauma in anamnesis, a11 - psychoemotional tension, a12 - meteolability, a13 - cervical osteochondrosis, a14 - ORL pathology, a15 - availability of perinatal trauma in anamnesis with pronounced hypertension-hydrocephalic syndrome, a16 - availability of paroxysmal activity, a17 - availability and manifestation value of dysfunction of diencephalic structures. At F1 ≥ F2 on should predict the development of remote aftereffects in young people due to evaluating premorbid background of a patients at the moment of trauma.

EFFECT: higher reliability of prediction.

2 ex, 1 tbl

FIELD: medicine; medical engineering.

SUBSTANCE: method involves doing multi-channel recording of electroencephalogram and carrying out functional tests. Recording and storing rheoencephalograms is carried out additionally with multi-channel recording of electroencephalogram synchronously and in real time mode in carotid and vertebral arteries. Electroencephalograms and rheoencephalograms are visualized in single window with single time axis. Functional brain state is evaluated from synchronous changes of electroencephalograms, rheoencephalograms and electrocardiograms in response to functional test. The device has electrode unit 1 for recording bioelectric brain activity signals, electrode unit 2 for recording electric cardiac activity signals, current and potential electrode unit 3 for recording rheosignals, leads commutator 4, current rheosignal oscillator 5, synchronous rheosignal detector 6, multi-channel bioelectric brain activity signals amplifier 7, electrophysiological signal amplifier 8, demultiplexer 9, multi-channel rheosignal amplifier 10, multi-channel analog-to-digital converter 11, micro-computer 12 having galvanically isolated input/output port and personal computer 13 of standard configuration.

EFFECT: enhanced effectiveness of differential diagnosis-making.

11 cl, 6 dwg

FIELD: medicine; medical engineering.

SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.

EFFECT: wide range of functional applications.

15 cl, 10 dwg

FIELD: medicine, psychiatry.

SUBSTANCE: one should conduct EEG-testing to detect total value of the indices of spectral power or percentage spectral power of delta- and teta-rhythms due to spectrometric technique in frontal, parietal, central and temporal areas both before and during emotional-negative loading when visual emotionally negative stimuli are presented followed by their imaginary reproduction. In case of higher indices to visual stimuli being above 15% against the background one should diagnose epilepsy. The method enables to increase the number of diagnostic means, increase accuracy and objectivity in predicting epilepsy with polymorphic paroxysms at dissociation of clinical and EEG-values.

EFFECT: higher efficiency of diagnostics.

1 ex, 1 tbl

FIELD: medicine, neurophysiology.

SUBSTANCE: one should carry out EEG survey to detect spectrometrically the index of full range if alpha-rhythm both before and after therapy. Moreover, power index of full range of alpha-rhythm and the index of 9-10 Hz-strip's spectral power should be detected in occipital cerebral areas. One should calculate the value of the ratio of the index of 9-10 Hz-strip's spectral power to the index of full range of alpha-rhythm and at the increase of this value by 20% against the background it is possible to evaluate positive result of therapy. The method increases the number of diagnostic means applied in evaluating therapeutic efficiency in the field of neurophysiology.

EFFECT: higher efficiency of evaluation.

1 ex

FIELD: medicine, neurology.

SUBSTANCE: method involves carrying out the standard vascular and nootropic therapy. Diazepam is administrated under EEG control with the infusion rate that is calculated by the following formula: y = 0.0015x - 0.025 wherein y is the rate of diazepam administration, mg/h; x is an average EEG amplitude, mcV. Method provides enhancing the effectiveness of treatment of patients. Invention can be used for treatment of patients in critical severe period of ischemic insult.

EFFECT: enhanced effectiveness of treatment.

2 tbl, 1 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: method involves selecting signals showing patient consciousness level and following evoked auditory potentials as responses to repeating acoustic stimuli, applying autoregression model with exogenous input signal and calculating AAI index showing anesthesia depth next to it.

EFFECT: quick tracing of unconscious to conscious state and vice versa; high accuracy of measurements.

9 cl, 3 dwg

FIELD: medicine; experimental and medicinal physiology.

SUBSTANCE: device can be used for controlling changes in functional condition of central nervous system. Device has receiving electrodes, unit for reading electroencephalograms out, analog-to-digital converter and inductor. Low noise amplifier, narrow band filter linear array which can be program-tuned, sample and store unit, online memory, microcontroller provided with controlled permanent storage, liquid-crystal indicator provided with external control unit are introduced into device additionally. Receiving electrodes are fastened to top part of patient's head. Outputs of electrodes are connected with narrow band filters linear array through electroencephalograph. Output of linear array is connected with input of input unit which has output connected with input of analog-to-digital converter. First bus of analog-to-digital converter is connected with online storage. Recording/reading bus of microcontroller is connected with control input of input unit and its starting bus is connected with address input of online storage. Third control bus is connected with narrow band filters linear array. Second control bus is connected with liquid-crystal indicator. Output bus is connected with inductor. External control (keyboard) of first control bus is connected with microcontroller. Output of online storage is connected with data input of microcontroller through 12-digit second data bus. Efficiency of influence is improved due to getting specific directed influence being based onto general technological transparency of processing of human brain's signals and strictly specific influence based on the condition of better stimulation.

EFFECT: increased efficiency.

3 cl, 1 dwg, 1 tbl

FIELD: medicine, neurology, professional pathology.

SUBSTANCE: one should carry out either biochemical blood testing and electroencephalography or SMIL test, or ultrasound dopplerography of the main cranial arteries, rheoencephalography (REG) to detect the volume of cerebral circulation and hypercapnic loading and their digital values. Then it is necessary to calculate diagnostic coefficients F by the following formulas: Fb/e=6.3-0.16·a1+0.12·a2-1·a3+0.2·a4, or FSMIL=9.6+0.16·a5-0.11·a6-0.14·a7+0.07·a8, or Fhem=48.6-0.04·a9+0.15·a10+13.7·a11-0.02·a12+24.7·a13, where Fb/e -diagnostic coefficient for biochemical blood testings and EEG; FSMIL - diagnostic coefficient for SMIL test; Fhem - diagnostic coefficient for hemodynamic testing; 6.3; 9.6 and 48.6 - constants; a1 - the level of vitamin C in blood; a2 - δ-index by EEG; a3 - atherogenicity index; a4 - the level of α-proteides in blood; a5 - scale 3 value by SMIL; a6 - scale K value by SMIL; a7 - scale 5 value by SMIL; a8 - scale 7 value by SMIL; a9 - the level of volumetric cerebral circulation; a10 - the value of linear circulatory rate along total carotid artery, a11 - the value of resistive index along total carotid artery; a12 - the value for the tonicity of cerebral vessels at carrying out hypercapnic sampling by REG; a13 - the value for the intensity of cerebral circulation in frontal-mastoid deviation by REG. At F value being above the constant one should diagnose toxic encephalopathy, at F value being below the constant - discirculatory encephalopathy due to applying informative values.

EFFECT: higher accuracy of diagnostics.

6 ex, 1 tbl

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