Product for oral cavity care and methods of its application and manufacturing


FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed group of inventions relates to composition for oral cavity care and methods of its application. Claimed is composition for oral cavity care, which contains: arginine, in free form or in form of salt in amount from 0.1 to 20 wt % of total composition weight; triclosan in amount from 0.01 to 5 wt % of total composition weight; anionic polymer, which is a copolymer of methyl vinyl ether and maleic anhydrate; anionic surfactant in amount from 0.01 to 10 wt % of total composition weight; soluble fluoride salt in amount from 0.01 to 2 wt % of total body weight, in order to provide 50-25000 ppm of weight of fluoride ions, in which soluble fluoride salt or source of fluoride ions is selected from sodium fluoride, sodium monofluorophosphate and their mixtures; and abrasive material, which contains fraction of minor particles, constituting at least about 5 wt % of total composition weight, and in said fraction minor particles have average diameter d50 smaller than 5 mcm.

EFFECT: application of composition for oral cavity care along with improved delivery of antibacterial agent provides additional advantages in acceleration of remineralisation and restoration of precarious affection foci due to combination of fluoride and arginine, as well as due to application of finely disperse abrasive as composition component.

11 cl, 1 tbl, 7 ex

 

This application claims priority to the following applications: application U.S. No. 61/027431, filed February 8, 2008, application U.S. No. 61/027432, filed February 8, 2008, and application U.S. No. 61/027420, filed February 8, 2008, the contents of which are incorporated into this invention by reference.

The SCOPE of the INVENTION

The present invention relates to compositions for the care of the oral cavity, containing the basic amino acid in free form or in salt form, and an antibacterial agent such as triclosan, and to methods of use and creation of these songs.

PRIOR INVENTIONS

In order to care for the oral cavity have been proposed arginine and other basic amino acids, which are considered to be significantly effective against the formation of cavities and tooth sensitivity. However, it is confirmed that the combination of these basic amino acids with minerals that are effective for the maintenance of the oral cavity, for example with fluorine compound and calcium, is a difficult task when creating a product for the care of the oral cavity with acceptable long-lasting stability. In particular, the essential amino acid can increase the pH level and to promote the dissociation of calcium ions, which can react with fluorine ions with formation of insoluble precipitate. In addition, Bo is its high pH may cause irritation. However, the system utilization of arginine bicarbonate (which is preferred according to the prior art) at neutral or acidic pH may release carbon dioxide, which leads to swelling and rupture of containers. In addition, it can be expected that by reducing the pH to a neutral or acidic reaction will decrease the effectiveness of the preparative form, because arginine can form insoluble complex of arginine-calcium, which has a weaker affinity for the tooth surface, and, in addition, the decrease in pH will reduce any possible buffer action formulation against cariogenic effect of lactic acid in the mouth. Partly because of such vague problems with the preparative form and partially because arginine according to the art is usually considered as a potential alternative to fluoride, but not together as the operating agent, there was a weak motivation to manufacture products for the care of the oral cavity, and containing arginine and fluoride. Additional obstacles were potential in adding an antibacterial agent. For example, commercially available toothpaste on the basis of arginine, such as ProClude® and DenClude®, contains arginine bicarbonate and calcium carbonate, but does not contain fluoride, or whether what about antibacterial.

At the same time, many dentists recognize the importance of having in toothpaste antibacterial agents such as triclosan. Thus there is the problem of delivering an effective amount of these funds to the teeth and gums, and their solubility, delivery and retention of the teeth depends on the recipe. For example, triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) is poorly soluble in water.

Thus, there is a need for sustainable product for the care of the oral cavity, which contains a basic amino acid and contains has a useful effect of minerals such as fluoride and calcium, as well as the need for product with improved delivery of antibacterial agents.

A BRIEF summary of the INVENTION

Now unexpectedly discovered that the basic amino acid such as arginine, can significantly increase the solubility, delivery, retention and effectiveness against bacteria antibacterial agents such as triclosan.

Thus, the present invention encompasses a composition for the care of oral cavity and methods of their use that effectively prevent or reduce the formation of plaque, reduce the number of bacteria that produce acid (cariogenic), which have the effect of remineralization of the teeth and prevent or reduce the development of gingivitis is. The present invention also encompasses compositions and methods for cleaning the oral cavity and improved ways of promoting oral health and/or health of the whole body, including the health of the cardiovascular system, for example, by reducing the possibility of systemic infection through the tissues of the mouth.

Thus, the present invention relates to compositions for the care of the oral cavity (the composition of the invention), such as a toothpaste that contains:

(i) an effective amount of basic amino acid in free form or in salt form, for example arginine;

(ii) an effective amount of an antibacterial agent such as triclosan.

Optionally, the present invention further comprises anionic surfactant, for example sodium lauryl sulphate; an effective amount of a fluoride source, such as a soluble fluoride salt; and/or anionic polymer, for example a copolymer metilfenidato ether and maleic anhydride. Thus, in one embodiment, the invention relates to a toothpaste containing arginine salt, such as hydrochloride, arginine, arginine phosphate or bicarbonate arginine; triclosan; anionic surfactant such as sodium lauryl sulfate; soluble fluoride salt, for example monitoroff sodium or sodium fluoride.

In one embodiment, about what westline the invention relates to compositions according to the invention (composition 1.1), optionally containing particles, the composition having an index of RDA (abrasive wear of dentin by radioactive method) less than about 200, for example less than about 160, for example from about 40 to about 140, for example, containing at least about 5%, for example at least about 20% of the particles having an average diameter d50 of less than about 5 micrometers, for example silica particles having a d50 of about 3 to about 4 micrometers, or precipitiously calcium carbonate having a d50 from about 0.5 to about 3 micrometers.

In specific embodiments, the implementation of the compositions according to the invention represent a toothpaste containing additional components selected from one or more components: water, abrasives, surfactants, foaming agents, vitamins, polymers, enzymes, wetting agents, thickeners, antimicrobial agents, preservatives, fragrances, dyes, and/or combinations thereof.

Without specific theory, it is assumed that a significant factor in the beneficial effect of arginine is the possibility of absorption of arginine and other basic amino acids by certain types of bacteria, such as S. sanguis, which are not cariogenic and compete for a position on the teeth and oral cavity with cariogenic bacteria such as S. mutans. Alginolyticus bacteria can in order to emanate arginine and other basic amino acids for the production of ammonia, thus increasing the pH of their environment, whereas cariogenic bacteria metabolize sugars to produce lactic acid, which tends to lower the pH of plaque and demineralization of the teeth, which eventually leads to the formation of cavities. It is believed that regular use over a long period of time, the composition of the invention will lead to a relative increase alginolyticus bacteria and the relative decrease in the number of cariogenic bacteria, resulting in an increase of the pH of the plaque, formed the resistance of teeth to cariogenic bacteria and their harmful effects. It is assumed that the effect of an increase in pH can be mechanically separated from the action of fluoride and can complement the action of fluoride on accelerating remineralize and strengthen tooth enamel.

However, regardless of the exact mechanism of action it has been unexpectedly discovered that the combination of fluoride and basic amino acids such as arginine in the product to care for the oral cavity according to specific variants of implementation of the present invention creates unexpected additional benefits in accelerating remineralization, repair foci precarized defeat and strengthening of oral health, which are qualitatively different from the effect which can be observed when PR is changing compositions, containing an effective amount of any of the compounds individually. In addition, it was found that this effect can be further strengthened by adding a fine abrasive, which can contribute to the filling of micro-cracks in the enamel and microcannulas in dentin.

Also unexpectedly discovered that the presence of basic amino acids reduces the adhesion of bacteria to the tooth surface, in particular in the case of the combination of the basic amino acid with an anionic surfactant.

Of particular importance for the present invention is that the primary amino acid significantly increases the solubilization, release, delivery, deposition and effectiveness of antibacterial agents such as triclosan.

Thus, the present invention additionally relates to methods (i) reduce or prevent the formation of dental caries, (ii) reduce, repair, or prevent early damage to the enamel, for example, detected by quantitative light fluorescence (QLF) or electrometric method for the determination of caries (ECM), (iii) reduce or prevent demineralization and acceleration remineralization of the teeth, (iv) reduce hypersensitivity of the teeth, (v) reduce or prevent gingivitis, (vi) promote healing of ulcers and wounds in the cavity, R is a, (vii) reduce the number of bacteria that produce acid, (viii) increasing the relative content of alginolyticus bacteria, (ix) prevent the formation of microbial biofilms in the oral cavity, (x) raise and/or maintain after sugar load pH of the plaque at least at the level of pH 5.5, (xi) reduce plaque formation, (xii) treat, relieve or reduce severe dry mouth; (xiii) strengthen health in General, including the health of the cardiovascular system, for example, by reducing common infection through the tissues of the mouth, (xiv) reduce erosion of the teeth, (xv) whiten teeth, (xvi) the formation of resistance or protection of the teeth against cariogenic bacteria; and/or (xvii) the cleansing of the teeth and oral cavity, which contain the use of a composition according to the invention in the oral cavity, for example the use of a composition according to the invention in the oral cavity of a patient in need of such use.

DETAILED description of the INVENTION

Thus, the present invention provides a composition for the care of oral cavity (composition 1.0), containing

(i) an effective amount of basic amino acids such as arginine, in free form or in salt form;

(ii) an effective amount of an antibacterial agent such as triclosan; and

(iii) optionally, anionic the surfactant, for example sodium lauryl sulphate; an effective amount of a fluoride source, such as a soluble fluoride salt; and/or anionic polymer, for example a copolymer metilfenidato ether and maleic anhydride;

for example, any of the following compositions.

1.0.1. The composition is 1.0, in which the basic amino acid is an arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutane acid, diaminopropionic acid, their salts and/or their combinations.

1.0.2. The composition is 1.0 or 1.0.1, in which the basic amino acid is L-configuration.

1.0.3. Any of the previous compositions, presented in the form of salts of di - or Tripeptide containing a basic amino acid.

1.0.4. Any of the previous compositions, in which the basic amino acid is arginine.

1.0.5. Any of the previous compositions, in which the basic amino acid is L-arginine.

1.0.6. Any of the previous compositions, in which the basic amino acid is represented completely or partially in salt form.

1.0.7. Composition 1.0.6, in which the basic amino acid is arginine phosphate.

1.0.8. Composition 1.0.6, in which the basic amino acid is in the form of arginine hydrochloride.

1.0.9. Composition 1.0.6, in which the basic amino acid is arginine sulfate.

1.0.10. Composition 1.0.6, in which the basic amino acid is Oh is arginine bicarbonate.

1.0.11. Any of the previous compositions, in which the salt of the basic amino acids formed in the recipe in situ by neutralization of the basic amino acid or salt of the acid.

1.0.12. Any of the previous compositions, in which the salt of the basic amino acids are formed by neutralization of the basic amino acid to obtain a premix before combining with a fluoride salt.

1.0.13. Any of the previous compositions, in which the basic amino acid is present in such quantity that the weight corresponds to from about 0.1 to about 20%, for example from about 1% to about 10%, of the total weight of the composition, the weight of the basic amino acid is calculated by weight of the free base form.

1.0.14. Composition 1.0.11, in which the basic amino acid is present in amount of about 7.5% weight of the total weight of the composition.

1.0.15. Composition 1.0.11, in which the basic amino acid is present in an amount of about 5% by weight of the total weight of the composition.

1.0.16. Composition 1.0.11, in which the basic amino acid is present in amount of about 3.75% by weight of the total weight of the composition.

1.0.17. Composition 1.0.11, in which the basic amino acid is present in an amount of about 1.5% weight of the total weight of the composition.

1.0.18. Any of the previous compositions, in which the fluoride salt is selected from tin fluoride, sodium fluoride, potassium fluoride, monophosphate intothree is, fertilitate sodium, fertilitate ammonium, amine fluoride (for example, N'-octadecyltrimethylammonium-N,N,N'-Tris(2-ethanol)-dihydrofluoride), ammonium fluoride, titanium fluoride, hexaferrite and combinations thereof.

1.0.19. Any of the previous compositions, in which the fluoride salt is perforat.

1.0.20. Any of the previous compositions, in which the fluoride salt is monitoroff sodium.

1.0.21. Any of the previous compositions, in which the fluoride salt is sodium fluoride.

1.0.22. Any of the previous compositions, in which the fluoride salt is present in amount from about 0.01 wt% to about 2% weight of the total weight of the composition.

1.0.23. Any of the previous compositions, in which the fluoride salt contains fluoride ion in an amount of from about 0.1 to about 0.2% by weight of the total weight of the composition.

1.0.24. Any of the previous compositions, in which a soluble fluoride salt contains fluoride ion in an amount of from about 50 to about 25,000 hours/million

1.0.25. Any of the previous songs, which is a liquid mouth rinse containing from about 100 to about 250 hours/million digestible fluoride ions.

1.0.26. Any of the previous songs, which is a toothpaste having from about 750 to about 2000 hours/million digestible fluoride ions.

1.0.27. Any of the previous songs, which will gain from about 750 to about 2000 hours/million fluoride ions.

1.0.28. Any of the preceding compositions which contain from about 1000 to about 1500 hours/million fluoride ions.

1.0.29. Any of the previous songs, which contains approximately 1450 hours/million fluoride ions.

1.0.30. Any of the preceding compositions in which the pH is from about 6 to about 9, for example from about 6.5 to about 7.4, or from about 7.5 to about 9.

1.0.31. Any of the preceding compositions in which the pH is from about 6.5 to about 7.4.

1.0.32. Any of the preceding compositions in which the pH is from about 6.8 to about 7.2.

1.0.33. Any of the preceding compositions in which the pH is close to neutral.

1.0.34. Any of the previous compositions, optionally containing abrasive or particles.

1.0.35. Immediately preceding the composition in which the abrasive or particles are selected from sodium bicarbonate, calcium phosphate (e.g., dicalcium dehydrate-phosphate), calcium sulphate, calcium carbonate (for example, precipitating calcium carbonate), silica (e.g., hydrated silica), iron oxide, aluminum oxide, perlite, plastic particles, such as polyethylene, and combinations thereof.

1.0.36. Immediately preceding the composition in which the abrasive or particles selected from a calcium phosphate (e.g., dicalcium dehydrate-phosphate), calcium sulfate, precipitating calcium carbonate is, silicon (e.g., hydrated silica), and combinations thereof.

1.0.37. Any of the above compositions, optionally containing an abrasive in an amount of from about 15% weight to about 70% weight of the total weight of the composition.

1.0.38. Any of the above compositions, optionally containing fraction is at least about 5% of the abrasive particles, the average diameter d50 which is less than about 5 microns.

1.0.39. Any of the above compositions with figure RDA of less than about 150, for example from about 40 to about 140.

1.0.40. Any of the above compositions, optionally containing anti-Tartar.

1.0.41. Any of the above compositions, optionally containing anti-Tartar, which represent a polyphosphate, such as pyrophosphate, tripolyphosphate or hexametaphosphate, for example, in the form of sodium salt.

1.0.42. Any of the above compositions, optionally containing at least one surfactant.

1.0.43. Any of the above compositions, optionally containing at least one surfactant selected from sodium lauryl sulfate, cocamidopropylbetaine and combinations thereof.

1.0.44. Any of the above compositions, optionally containing anionic surfactant.

1.0.45. Any of the above compositions, optionally containing sodium lauryl sulfate.

p> 1.0.46. Any of the previous compositions, optionally containing at least one moisturizer.

1.0.47. Any of the above compositions, optionally containing at least one moisturizing agent selected from glycerin, sorbitol, xylitol, and combinations thereof.

1.0.48. Any of the above compositions, optionally containing xylitol.

1.0.49. Any of the above compositions, optionally containing at least one polymer.

1.0.50. Any of the above compositions, optionally containing at least one polymer selected from polyethylene glycols, copolymers of polivinilbutilovy and maleic acid, polysaccharides (e.g. cellulose derivatives such as carboxymethyl cellulose or polysaccharide gums, such as xanthan gum or carrageenan), and combinations thereof.

1.0.51. Any of the above compositions, optionally containing ribbons or pieces of resin.

1.0.52. Any of the above compositions, optionally containing flavouring, fragrance and/or dye.

1.0.53. Any of the above compositions, optionally containing water.

1.0.54. Any of the above compositions containing an antibacterial agent selected from halogenated diphenyl ether (e.g., triclosan), herbal extracts and essential oils (for example, ex is ract rosemary, tea extract, Magnolia extract, thymol, menthol, eucalyptol, geraniol, carvacrol, citral, hinokitiol, catechol, ether methylsalicylic acid, gallate of epigallocatechin, epigallocatechin, Gallic acid, extract of miswak extract, sea-buckthorn), antiseptics group biguanide (e.g., chlorhexidine, alexidine or octenidine), Quaternary ammonium compounds (for example, cetylpyridinium chloride (CPH), benzalkonium chloride, tetradecylbenzene chloride (TNX), N-tetradecyl-4-ethylpyridine chloride (TDAP)), phenolic antiseptics, hexetidine, octenidine, sanguinarine, povidone-iodine, delmopinol, calyptra (5-n-octanoyl-3'-trifluoromethyl-salicylanilide), metal ions (e.g., zinc salts such as zinc citrate, salts of tin, copper salt, iron salt), propolis and oxigenada agents (e.g. hydrogen peroxide, buffered peroxyborate or peroxocarbonate sodium), phthalic acid and its salts, monophthalmos acid and its salts and esters, ascorbyl-stearate, oleoyl-sarcosine, alkylsulfate, dioctyl-sulfosuccinate, salicylanilide, domiphen-bromide, delmopinol, and other Octafinal piperidinovyh derivatives, drugs Nizina, chloride salts of the acid and mixtures of any of the above funds.

1.0.55. Any of the above compositions, optionally containing an anti-inflammatory compound such as an inhibitor of at least one of the source of proinflammatory factors, choose from matrix metalloproteinases (MMP), cyclooxygenase (COX)and prostaglandin E2(PGE2), interleukin-1 (IL-1), IL-1β-converting enzyme (ICE), transforming growth factor β1 (TGF-β1), inducible synthase nitric oxide (iNOS), hyaluronidase, cathepsins, nuclear factor Kappa-B (NF-κB) and IL-1 receptor-associated kinase (IRAK), which selects, for example, aspirin, Ketorolac, flurbiprofen, ibuprofen, naproxen, indomethacin, aspirin, Ketoprofen, piroxicam, meclofenamic acid, nordihydroguaiaretic acid and mixtures thereof.

1.0.56. Any of the above compositions, optionally containing an antioxidant of choice, for example, from the group consisting of coenzyme Q10, PQQ, vitamin C, vitamin E, vitamin a, anethole-ditation and mixtures thereof.

1.0.57. Any of the above compositions containing antibacterial with poor solubility, for example, solubility is higher than that of triclosan.

1.0.58. Any of the above compositions, which contains antibacterial triclosan.

1.0.59. Any of the above compositions containing triclosan and xylitol.

1.0.60. Any of the above compositions containing triclosan, xylitol and precipitiously calcium carbonate.

1.0.61. Any of the above compositions, optionally containing triclosan and istochniki Zn 2+for example the zinc salt of citric acid.

1.0.62. Any of the above compositions, optionally containing an antibacterial agent in an amount of from about 0.01 to about 5% by weight of the total weight of the composition.

1.0.63. Any of the above compositions, optionally containing triclosan in an amount of from about 0.01 to about 1 wt%. the total weight of the composition.

1.0.64. Any of the above compositions, optionally containing triclosan in the amount of about 0.3% of the total weight of the composition.

1.0.65. Any of the above compositions, optionally containing a bleaching agent.

1.0.66. Any of the above compositions, optionally containing a bleaching agent, selected from the active bleach, which is selected from the group consisting of peroxides, metal chlorite, perborates, percarbonates, peroxyketal, hypochlorites, and combinations thereof.

1.0.67. Any of the above compositions, optionally containing hydrogen peroxide or a source of hydrogen peroxide such as urea peroxide or a peroxide salt or complex (such as proxyport, peroxocarbonate, perborate, peroxisomal or persulfate salts; for example, proxyport calcium, perborate sodium peroxide sodium carbonate, proxyport sodium and potassium persulfate), or polymeric complexes of hydrogen peroxide, the same is as polymer complexes of polyvinylpyrrolidone - the hydrogen peroxide.

1.0.68. Any of the above compositions, optionally containing an agent that inhibits or prevents the fixation of bacteria, for example solpol or chitosan.

1.0.69. Any of the above compositions, optionally containing a calcium source and a phosphate selected from (i) complexes of calcium-glass, such as calcium-sodium phosphosilicate, and (ii) complexes the calcium-protein, such as casein-phosphopeptide-amorphous calcium phosphate.

1.0.70. Any of the above compositions, optionally containing a soluble salt of calcium, for example, selected from calcium sulfate, calcium chloride, calcium nitrate, calcium acetate, calcium lactate, and combinations thereof.

1.0.71. Any of the above compositions, optionally containing a physiologically acceptable salt of potassium, such as potassium nitrate or potassium chloride, in an amount effective to reduce the sensitivity of dentin.

1.0.72. Any of the above compositions additionally containing from about 0.1% to about 7.5% of physiologically acceptable salts of potassium, such as potassium nitrate and/or potassium chloride.

1.0.73. Any of the above compositions, which is a toothpaste containing a salt of arginine, such as arginine hydrochloride, arginine phosphate or bicarbonate arginine; triclosan; anionic surfactant such as sodium lauryl when lift; and a soluble fluoride salt, for example monitoroff sodium or sodium fluoride.

1.0.74. Any of the above compositions is effective for use in the oral cavity, for example, when the cleaning brush (i) to reduce or prevent the formation of dental caries, (ii) reduce, repair or prevent precariously damage to the enamel, for example, detected by quantitative light fluorescence (QLF) or electrometric method for the determination of caries (ECM), (iii) to reduce or prevent demineralization and facilitate remineralization of the teeth, (iv) reduce hypersensitivity of the teeth, (v) to reduce or prevent gingivitis, (vi) promote healing of sores and wounds in the mouth, (vii) to reduce the number of bacteria that produce acid, (viii) to increase relative content alginolyticus bacteria, (ix) to prevent the formation of microbial biofilms in the oral cavity, (x) raise and/or maintain after sugar load pH of the plaque at least at the level of pH 5.5, (xi) reduce plaque formation, (xii) treat, relieve or reduce severe dry mouth; (xiii) for cleansing the teeth and oral cavity (xiv) reduce erosion, (xv) whiten teeth, and/or (xvi) improve the stability of the teeth against cariogenic bacteria.

1.0.75. Composition, creating the controls or obtained by a combination of components, according to the wording of any of the above compositions.

1.0.76. Any of the above compositions in the form selected from means for mouthwash, toothpaste, tooth gel, tooth powder, non-abrasive gel, mousse, foam, spray for the mouth, pastilles, tablets for mouth, a tooth implant and product to care for Pets.

1.0.77. Any of the above compositions, representing toothpaste.

1.0.78. Any of the above compositions, representing toothpaste, which optionally additionally contains one or more of the one or more of the following components: water, abrasive, surfactant, foaming remedies, vitamins, polymers, enzymes, humectants, thickeners, anti-bacterial viewest, preservatives, fragrances, dyes, and/or combinations thereof.

1.0.79. Any of the above compositions 1.0-1.0.76 representing a liquid for rinsing the mouth.

1.0.80. Any of the above compositions, optionally containing breath freshener, perfume or flavoring.

In another embodiment, the scope of the invention is the composition according to the invention (composition 1.1), for example, corresponding to any of the above compositions 1.0-1.0.80, which contains

(i) an effective amount of the salt of the basic amino acids;

(ii) an effective amount RA is soluble fluoride salt;

(iii) anionic surfactant such as sodium lauryl sulfate;

(iv) anionic polymer such as a copolymer metilfenidato ether and maleic anhydride; and

(v) an antibacterial agent such as triclosan.

In another embodiment, the scope of the invention is the composition according to the invention (composition 1.2), for example, corresponding to any of the above compositions 1.0-1.0.80, which contains

i. an effective amount of the salt of the basic amino acids;

ii. antibacterial agent such as triclosan;

iii. an effective amount of a soluble fluoride salt and

iv. abrasive particles, which composition has a RDA of less than about 160, for example from about 40 to about 140, for example, contains at least about 5%, for example at least about 20% of abrasive particles having a d50 less than about 5 μm, for example silicon particles having a d50 of about 3 to about 4 microns.

In another embodiment, the scope of the invention includes a method (method 2) to improve the health of the oral cavity, containing the application in the oral cavity in need thereof of a subject an effective amount of the composition for the oral cavity according to any one of embodiments for the compositions 1.0, 1.1, or 1.2, such as how to

(i) reduce or prevent the formation of dental caries;

(ii) slimming is, restore or prevent early damage to the enamel, for example, detected by quantitative light fluorescence (QLF) or electrometric method for the determination of caries (ECM);

(iii) reduce or prevent demineralization and facilitate the remineralization of teeth.

(iv) reduce hypersensitivity of the teeth;

(v) reduce or prevent gingivitis;

(vi) promote healing of ulcers and wounds in the mouth;

(vii) reduce the number of bacteria that produce acid;

(viii) increase the relative content of alginolyticus bacteria;

(ix) prevent the formation of microbial biofilms in the oral cavity;

(x) raise and/or maintain after sugar load level plaque pH of at least pH 5,5;

(xi) reduce plaque formation;

(xii) treat, relieve or reduce severe dry mouth.

(xiii) strengthen health in General, which includes the health of the cardiovascular system, for example, by reducing the total probability of infection through the tissues of the oral cavity;

(xiv) teeth whitening;

(xv) reduce erosion;

(xvi) improve the stability of the teeth against cariogenic bacteria, and/or

(xvii) for cleansing the teeth and oral cavity.

The present invention further comprises the use of arginine in the production of songs and according to the invention, for example, for use in any of the indications formulated for method 2.

The present invention additionally relates to compositions for the care of oral cavity, containing the basic amino acid in free form or in salt form, and antibacterial use for antibacterial treatment of the oral cavity of the subject.

The present invention additionally relates to compositions for the care of oral cavity, containing an antibacterial agent and a basic amino acid in free form or in salt form to increase the delivery of an antibacterial agent on the surface in the oral cavity of the subject.

The present invention additionally relates to the use of a basic amino acid in free form or in salt form in the composition for the care of the oral cavity, which contains antibacterial, to increase the delivery of an antibacterial agent on the surface in the oral cavity of the subject and application of the basic amino acid in free form or in salt form, for the manufacture of drugs, which contains an antimicrobial agent for use in order to increase the delivery of an antibacterial agent on the surface in the oral cavity of the subject.

The present invention additionally relates to a method for increasing delivery of antibacterial the th funds from the composition for the care of the oral cavity on the surface of the oral cavity of the subject, by the way, which contains the treatment of the oral cavity with a composition for caring for the oral cavity that contains antibacterial and basic amino acid in free form or in salt form.

Qualified specialist in the care of the oral cavity may be noted that the unexpected effectiveness of technology and the advantage of increased delivery of antibacterial agents to the teeth can be due to the formulation and use of a composition for the care of the oral cavity, such as toothpaste, according to one or more aspects of the present invention, which aims at ensuring the combinations of active components or ingredients and, preferably, the corresponding quantities in the composition.

The antibacterial agent can be selected from halogenated diphenyl ether (e.g., triclosan), herbal extracts and essential oils (e.g., rosemary extract, tea extract, Magnolia extract, thymol, menthol, eucalyptol, geraniol, carvacrol, citral, hinokitiol, catechol, ether methylsalicylic acid, gallate of epigallocatechin, epigallocatechin, Gallic acid, extract of miswak extract, sea-buckthorn), antiseptics group biguanide (e.g., chlorhexidine, alexidine or octenidine), Quaternary ammonium compounds (for example, cetylpyridinium chloride (CPH), encalceu chloride, tetradecylbenzene chloride (TNX), N-tetradecyl-4-ethylpyridine chloride (TDAP)), phenolic antiseptics, hexetidine, octenidine, sanguinarine, povidone-iodine, delmopinol, calyptra (5-n-octanoyl-3'-trifluoromethyl-salicylanilide), metal ions (e.g., zinc salts such as zinc citrate, salts of tin, copper salt, iron salt), propolis and oxigenada agents (e.g. hydrogen peroxide, buffered peroxyborate or peroxocarbonate sodium), phthalic acid and its salts, monophthalmos acid and its salts and esters, ascorbyl-stearate, oleoyl-sarcosine, alkylsulfate, dioctyl-sulfosuccinate, salicylanilide, domiphen-bromide, delmopinol, Octafinal and other piperidinovyh derivatives, drugs Nizina, chloride salts of the acid and mixtures of any of the above funds.

The composition may further contain an anti-inflammatory compound, for example an inhibitor of at least one of the source of proinflammatory factors selected from matrix metalloproteinases (MMP), cyclooxygenase (COX), PGE2, interleukin-1 (IL-1), IL-1β-converting enzyme (ICE), transforming growth factor β1 (TGF-β1), inducible synthase nitric oxide (iNOS), hyaluronidase, cathepsins, nuclear factor Kappa-B (NF-κB) and IL-1 receptor-associated kinase (IRAK), which selects, for example, aspirin, ketorol, the ka, flurbiprofen, ibuprofen, naproxen, indomethacin, aspirin, Ketoprofen, piroxicam, meclofenamic acid, nordihydroguaiaretic acid and mixtures thereof. The composition may additionally or alternatively contain an antioxidant, which selects, for example, from the group consisting of coenzyme Q10, PQQ, vitamin C, vitamin E, vitamin a, anethole-ditation and mixtures thereof.

The content of active ingredients will vary based on the characteristics of the delivery system, in particular their activity. For example, the content of the basic amino acid can vary from about 0.1 to about 20% of the weight (i.e. the weight of free base), for example from about 0.1 to about 3% by weight, in the liquid for rinsing the mouth, from about 1 to about 10% weight in the consumer toothpaste or from about 7 to about 20% weight in the product for professional or prescribed treatment. The content of fluoride present may be, for example, from about 25 to about 25,000 hours/million, for example from about 25 to about 250 hours/million in mouthwash, from about 750 to about 2000 hours/million in consumer toothpaste or from about 2000 to about 25,000 hours/million in product for professional or prescribed treatment. The content of the antibacterial agents will vary in a similar manner, the level of their contents, used for toothpaste, will be, for example, from about 5 to about 15 RA is higher than mouthwash. For example, in a liquid for rinsing of the mouth of the contents of triclosan may be, for example, about 0.03% of the weight of triclosan, while triclosan in toothpaste can be contained in an amount of about 0.3% of the weight of triclosan.

Basic amino acids

Basic amino acids that can be prominenet in the compositions and methods of the present invention include not only the basic amino acids of natural origin, such as arginine, lysine and histidine, but also any basic amino acids having in the molecule a carboxyl group, and amino group, which are soluble in water and have a pH in aqueous solution of about 7 or more.

Thus, the basic amino acids include, without limitation arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutane acid, diaminopropionic acid, their salts, or a combination. In a specific embodiment, the basic amino acid selected from arginine, citrulline and ornithine.

In some embodiments, the implementation of the basic amino acid is arginine, such as L-arginine or its salt.

In some embodiments, the implementation of the basic amino acid comprises at least one intermediate product produced by the system deiminase arginine. Intermediate products produced by the system deiminase arginine, can be the useful in compositions for the care of oral cavity, to neutralize plaque in order to control and/or prevention of dental caries. Arginine is a basic amino acid of natural origin, which can be found in the oral cavity. Some bacterial strains plaque, such as S. sanguis, S. gordonii, S. parasangiuis, S. rattus, S. milleri, S. anginosus, S. faecalis, A. naeslundii, A. odonolyticus, L. cellobiosus, L. brevis, L.fermentum, P. gingivalis and T. denticola able to metabolize arginine in the mouth for their survival. These microorganisms can be killed in an acidic environment, which is located close to the tooth surface areas where acidogenic and acidurias cariogenic strains can utilizability sugar for the production of organic acids. Thus, these alginolyticus strains able to metabolize arginine to ammonia to create an alkaline reaction for their survival and, in addition, for separating zone spots and education corrosive environment cariogenic system.

These alginolyticus organisms able to metabolize arginine using the internal cellular enzymatic system of metabolism, called "system deiminase arginine", in which the formation of intermediate products of metabolism. In this process, L-arginine can split desiminate arginine to L-citrulline and ammonia. Then L-citrulline can split transcarbamylase of ornithine in the presence of inorganic phosphate to L-Ornit is on and carbamylphosphate. Kurbatkina, in turn, can split carbamylphosphate for the formation of another molecule of ammonia and carbon dioxide, and in this scheme also produces ATP (adenosine 5'-triphosphate). Alginolyticus bacteria can prominenet ATP as an energy source for growth. Thus, if the involved system deiminase arginine can form two molecules of ammonia.

It was found that in some embodiments, the implementation of ammonia can contribute to the neutralization of the pH of plaque in the oral cavity to control and/or prevention of dental caries.

According to some variants of implementation of the present invention, the composition for the care of the oral cavity may include intermediate products produced by the system deiminase arginine. Such intermediate products may include citrulline, ornithine and carbamylphosphate. In some embodiments, the implementation of a different composition for the care of oral cavity contains citrulline. In some embodiments, the implementation of the composition for the care of oral cavity contains ornithine. In some embodiments, the implementation of the composition for the care of oral cavity contains carbamylphosphate. In other embodiments, the implementation of the composition for the care of oral cavity contains any combination of citrulline, ornithine, carbamylphosphate and/or friends the intermediate products, generated by the system deiminase arginine.

Composition for the care of oral cavity may include the above described intermediate products in an effective amount. In some embodiments, the implementation of the content of intermediate products in the composition for the care of the oral cavity is from about 1 mmol/l to about 10 mmol/L. In other embodiments, the implementation of the composition for the care of oral cavity contains from about 3 mmol/l to about 7 mmol/l intermediate products. In other embodiments, the implementation of the composition for the care of oral cavity contains about 5 mmol/l intermediate products.

The composition of the invention are intended for topical application in the mouth and, accordingly, the salt used in the present invention, should be safe for a given application, the number and concentration of their content. Suitable salts include salts known in the art as pharmaceutically acceptable salts, which are used in quantities and concentrations in General are considered to be physiologically acceptable. Physiologically acceptable salts include salts formed from pharmaceutically acceptable inorganic or organic acids or bases, for example the acid additive salts derived from acids which form a physiological acceptable anion, nab the emer salt is hydrochloride or bromide, and the basic additive salts derived from bases, which form a physiologically acceptable cation, for example salts derived from alkali metals such as sodium and potassium, or alkaline earth metals such as calcium and magnesium. Physiologically acceptable salts can be obtained by standard procedures known in the art, for example, by reaction of a suitable basic compound such as an amine with a suitable acid, to obtain a physiologically acceptable anion.

In various embodiments, the implementation of the basic amino acid is present in amount from about 0.5% weight to about 20% weight of the total weight of the composition, from about 1% weight to about 10% weight of the total weight of the composition, for example about 1.5 wt%, about 3.75% by weight, about 5% by weight, or about 7.5% of the weight of the total weight of the composition.

RDA: the Term RDA is an abbreviated designation of the abrasive wear of dentin by radioactive method, a relative measure of abrasiveness. Usually extracted human tooth or cow is irradiated by a neutron flux, fixed in methyl methacrylate (bone glue), deprived of the enamel, is inserted in a brush machine, brush according to the standards of the American Dental Association (ADA) (standards toothbrush: pressure 150 g 1500 movements, the solution of water - toothpaste 4×1). Then measure and record radioactive is any liquid for rinsing. For control experiment, the test was repeated with toothpaste on the standard ADA, made of calcium pyrophosphate obtained in this case, the measurements had a value of 100 for calibrating a relative scale.

The source of fluoride ion

Compositions for the care of the oral cavity can optionally include one or more sources of fluoride ion, for example a soluble fluoride salt. As sources of soluble fluoride in the compositions of the present invention can be premanent a wide variety of materials forming the fluoride ions. Examples of suitable forming the fluoride ions of the materials described in U.S. patent No. 3535421 Briner et al.; in U.S. patent No. 4885155 Parran, Jr et al. and in U.S. patent No. 3678154 Widder et al., included as references in the present invention.

Examples of ion sources of fluoride include, without limitation, tin fluoride, sodium fluoride, potassium fluoride, monitoroff sodium, forcricket sodium, forcricket ammonium, amine fluoride, ammonium fluoride, and combinations thereof. In some embodiments, the implementation of a source of fluoride ion contains tin fluoride, sodium fluoride, monitoroff sodium, and mixtures thereof.

In some embodiments, the implementation arrangement for the care of the oral cavity of the present invention may also contain a source of fluoride ions or fluorine-containing component in the quantity rises the m to deliver from about 25 h/m to about 25,000 hours/million fluoride ions, in General, at least about 500 hours/million, for example from about 500 to about 2000 hours/million, for example, from about 1000 to about 1600 hours/million, for example, about 1450 hours/million Suitable levels of fluoride will depend on the particular application. For liquid for rinsing the mouth, for example, the typical will be the contents of from about 100 to about 250 hours per million) of fluoride. In toothpaste for General consumer use will be normal content of from about 1000 to about 1500 hours/million under slightly lower content in children's toothpaste. In toothpaste or coating for professional application of fluoride may be contained in the entire amount of about 5000 or even about 25,000 hours/million

In one embodiment, the ion sources of fluoride can be added to the composition according to the invention in quantities of from about 0.01% weight to about 10% by weight, or in another embodiment, from about 0.03% weight to about 5% by weight and from about 0.1% weight to about 1% weight by weight of the composition in another embodiment. Obviously, to achieve the proper content of fluoride ions weight fluoride salts will vary depending on the weight of the counterion in the salt.

Abrasives

The composition of the invention may contain collaborativity abrasive, such as tricalcium phosphate (Ca3(PO4)2), hydroxyapatite (Ca10(PO4)6(OH)2), or licalzi the phosphate dehydrate (CaHPO 4• 2H2O, also sometimes referred to in the present invention as DiCaI), or calcium pyrophosphate. Alternatively, as an abrasive can be used calcium carbonate and, in particular, precipitiously calcium carbonate.

The composition can include one or more additional abrasives, such as silicon abrasives, such as precipitiously silicon compounds, the average particle size of up to about 20 microns, such as Zeodent 115®, sold by J. M. Huber Corp. Other useful abrasives include metaphosphate sodium, metaphosphate potassium, aluminum silicate, calcined alumina, bentonite or other siliceous materials, or combinations thereof.

Polishing the silicon abrasive materials useful in the present invention, as well as the other abrasives, generally have an average particle size in the range from about 0.1 to about 30 microns, from about 5 to about 15 microns. Silicon abrasives can be obtained from precipitating silica or silica gels such as the silica xerogels described in U.S. patent No. 3538230 Pader et al. and in U.S. patent No. 3862307, Digiulio, and both of these patents incorporated by reference in the invention. Specific silica xerogels marketed under the trademark Syloid company W.R. Grace & Co., Davison Chemical Division. Precipitiously silicon materials include materials sold by J. Huber Corp. under the trademark Zeodent®, and include silicon-containing compounds under the designation Zeodent 115 and 119. These silicon abrasives are described in U.S. patent No. 4340583, Wason, included in the invention as a reference.

In some embodiments, the implementation of abrasive materials useful for making compositions for caring for the oral cavity according to the invention include silica gels and precipitiously amorphous silicon with a coefficient of absorption of less than about 100 cm3/100 g of silicon and in the range of from about 45 cm3/100 g to about 70 cm3/100 g silica. Measurement of the coefficient of absorption is carried out by grinding the pigment with oil according to the method D281 American society for testing and materials ASTM. In some embodiments, the implementation of the particles of colloidal silica have an average size from about 3 microns to about 12 microns, and from about 5 to about 10 microns.

In specific embodiments, the implementation of abrasive materials contain a large fraction of very small particles with an average diameter d50 of less than about 5 microns, such as fine silicon (MDK) d50 is from about 3 to about 4 microns, for example in Sorbosil AC43® (Ineos). Such microparticles are particularly useful in formulations intended to reduce the sensitivity. Fine component may be present in combination with the second and what razepam with larger particles. For example, in some embodiments, the implementation of the formulation contains from about 3 to about 8% of the microparticles, for example, MDK, and from about 25 to about 45% of normal abrasive.

Silicon abrasives with low oil absorption, particularly useful for carrying out the invention are sold under the trademark Sylodent XWA® company, Davison Chemical Division, W.R. Grace & Co., Baltimore, Md. 21203. The silicon hydrogel Sylodent XWA 650®*composed of particles of colloidal silica, with a water content of about 29% by weight, with a particle diameter on the average from about 7 to about 10 microns and an oil absorption of less than about 70 cm3/100 g of silicon, is an example of silicon coated with a low coefficient of absorption is useful for implementing the present invention. The concentration of abrasive in the composition for caring for the oral cavity according to the present invention is from about 10 to about 60% by weight, in another embodiment from about 20 to about 45% by weight and in another embodiment from about 30 to about 50% weight.

In some embodiments, the implementation of the basic amino acid is included in the composition of toothpaste with a basic recipe with calcium carbonate, and, in particular, contains precipitiously calcium carbonate as abrasive. By themselves, L-arginine and arginine salt, such as arginine bicarbonate, have a distinctly bitter internals of the Ohm, and in aqueous solution can also be transmitted fishy flavor. Therefore, it was assumed deterioration of the taste and mouth feel of formulations of toothpaste with the inclusion of L-arginine or arginine salts in effective concentrations in products for the care of the oral cavity, for example in the formulation of toothpaste, to make them effective against caries and to reduce the sensitivity, usually in an amount of from 2 to 10% by weight, calculated on the total weight of the formulation of toothpaste, compared to the same formulation without the addition of salts of arginine or L-arginine.

However, it was unexpectedly discovered in accordance with this aspect of the present invention that the addition of L-arginine or arginine salts to the basic recipe toothpaste containing calcium carbonate, can lead to a significant improvement of the taste and mouth feel of the specified recipe toothpaste and increase the overall acceptance of the product by the consumer.

Means to increase the amount of foam

Compositions for caring for the oral cavity according to the invention may also include means for increasing the amount of foam, which is formed when cleaning the oral cavity brush.

Illustrative examples of tools that increase the amount of foam include, without limitation, polyoxyethylene and some polymers, including but not limited to alginate polymer is.

Polyoxyethylene may increase the amount of foam and the thickness of the foam formed by the component carrier for maintenance of the oral cavity of the present invention. Polyoxyethylene also known as polyethylene glycol (PEG) or polyethylene oxide. Molecular weight suitable for the present invention of polyoxyethylene is from about 200,000 to about 7000000. In one embodiment, the molecular weight will be from about 600,000 to about 2000000 and in another embodiment from about 800,000 to about 1,000,000. Trademark high molecular weight polyoxyethylene is Polyox®produced by the company Union Carbide.

Polyoxyethylene may be present in amount from about 1% to about 90%, in one embodiment, from about 5% to about 50% and in another embodiment from about 10% to about 20% by weight of the component carrier for maintenance of the oral cavity compositions for the care of the oral cavity of the present invention. The content of the blowing means in the composition for the care of the oral cavity (i.e. monolithic dose) ranges from about 0.01 to about 0.9% by weight, from about 0.05 to about 0.5% by weight and in another embodiment from about 0.1 to about 0.2% of the weight.

Surfactants

Another tool, not necessarily to be included in the composition for the care of the oral cavity of the present invention, the submitted is a surfactant or a mixture of compatible surfactants. Suitable surfactants are surfactants with acceptable stability in a wide pH range, for example anionic, cationic, nonionic or zwitterionic surfactants.

Suitable surfactants are more fully described in, for example, in U.S. patent No. 3959458 Agricola et al.; in U.S. patent No. 3937807 Haefele and in U.S. patent No. 4051234 Gieske et al., included in the invention by reference.

In some embodiments, the implementation useful in the present invention the anionic surfactants include water-soluble salts of alkyl sulphates having an alkyl radical from about 10 to about 18 carbon atoms, and water soluble salts of sulfonated monoglycerides of fatty acids having from about 10 to about 18 carbon atoms. Sodium lauryl sulfate, sodium lauryl sarcosinate and coconut sodium monoglyceride the sulfonates are examples of anionic surfactants of this type. You can also apply a mixture of anionic surfactants.

In another embodiment, useful for the present invention, cationic surfactants can be broadly defined as derivatives of aliphatic Quaternary ammonium compounds having one long alkyl chain containing from about 8 to about 18 carbon atoms, such as lauryl trimethylammonium chloride, cetylpyridinium chloride, cetyltrimethylammonium bromide, diisobutyldimethoxysilane chlorite is, coconut alkyltrimethylammonium nitrite, cetylpyridinium fluoride and mixtures thereof.

Examples of cationic surfactants are Quaternary ammonium fluorides described in U.S. patent No. 3535421 Briner et al., included by reference in the present invention. Some cationic surfactants in the compositions can also have a bactericidal effect.

Examples of nonionic surfactants that can be prominenet in the compositions according to the invention can be broadly defined as compounds produced by the condensation alkalinising groups (hydrophilic characteristics) with an organic hydrophobic compound which may be aliphatic or alkylaromatic in nature. Examples of suitable nonionic surfactants include, without limitation pluronic, polyethylenoxide condensates of alkyl phenols, products derived from the condensation of ethylene oxide with the reaction product of propylene oxide and Ethylenediamine, ethyleneoxide condensates of aliphatic alcohols, tertiary amine oxide with long chain tertiary phosphine oxide with long chain, diallylsulfide long chain and mixtures of such funds.

In some embodiments, the implementation useful in the present invention zwitterionic synthetic surfactants can be broadly described as derivatives of compounds of aliphatic Quaternary ammonium, phosphonium and sulfone, in which Lam is practical radicals may be straight or branched chain, and in which one of the aliphatic substituents contains from about 8 to about 18 carbon atoms, and each one contains an anionic water-soluble group, such as carboxy, sulfonate, sulfate, phosphate or phosphonate. Illustrative examples of surfactants suitable for inclusion in the composition include without limitation sodium alkylsulfate, sodium lauroyl of sarcosinate, cocamidopropyl betaine, Polysorbate 20, and combinations thereof.

In a specific embodiment, the composition according to the invention contains an anionic surfactant such as sodium lauryl sulfate.

The surfactant or mixture of compatible surfactants can be present in the compositions of the present invention in an amount of from about 0.1% to about 5.0%, in another embodiment from about 0.3% to about 3.0% and in another embodiment from about 0.5% to about 2.0% of the total weight of the composition.

Flavouring tools

Compositions for caring for the oral cavity according to the invention may also include flavoring agent. The flavors that are used to implement the present invention, include without limitation, essential oils, and different aromatic aldehydes, esters, alcohols, and similar tools. Examples of essential oils include peppermint oil, curly, peppermint oil, Wintergreen oil, sassafras oil, clove oil, oil of the Alpheus, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit and orange. Also useful are such chemicals as menthol, carvon and anethole. In some embodiments, the implementation of the used oil curly mint, and peppermint.

Flavor is included in the composition in a concentration of from about 0.1 to about 5% by weight and from about 0.5 to about 1.5% by weight. Dose of flavor in the individual dose of the composition for the care of the oral cavity (i.e. monolithic dose) ranges from about 0.001 to about 0.05% by weight and in another embodiment from about from 0.005 to about 0.015 percent by weight.

Chelate tools

Compositions for caring for the oral cavity according to the invention can also optionally include one or more chelating means, are capable of forming complexes with calcium found in the cell wall of bacteria. The binding of calcium weakens the cell wall of bacteria and enhances the lysis of bacteria.

Another group of tools that are suitable for use in the present invention as a chelating agent is a soluble pyrophosphates. Pyrophosphate salts used in the compositions of the present invention can be any of pyrophosphate salts of alkali metals. In some embodiments, the implementation of the salt include tetramerista alkali metal, dvukhchastotnyi pyrophosphate on uselocale metal, monocolonal pyrophosphate trehserijnogo metal and mixtures thereof, with the alkali metals are sodium or potassium. Salts useful in their hydrated and UN-hydrated forms. An effective amount pyrophosphate salts useful in the compositions of the present invention, in General, sufficient to provide at least about 1.0% of the weight of pyrophosphate ion, from about 1.5 wt% to about 6% by weight, from about 3.5 wt% to about 6% by weight of the above mentioned ions.

Polymers

Compositions for caring for the oral cavity according to the invention also optionally include one or more polymers, such as polyethylene glycol, copolymers of polyphenylmethyl ether and maleic acid, polysaccharides (e.g. cellulose derivatives such as carboxymethyl cellulose or polysaccharide gums, such as xanthan gum or carrageenan). Acid polymers, such as polyacrylate gels, can be represented in the form of their free acids or partially or fully neutralized water soluble alkali metal (e.g. potassium and sodium) or ammonium salts.

In particular, if the composition of any of the components of toothpaste included nicotianae an antibacterial agent or an antibacterial agent such as triclosan, also preferably it includes from about 0.05 to about 5% means that uvelichenie the delivery and retention of the funds and their retention on the surfaces of the oral cavity. Such tools are useful in this invention are disclosed in U.S. patent No. 5188821 and 5192531 and include synthetic anionic polymeric polycarboxylate, such as copolymers of from 1:4 to 4:1 of maleic anhydride or acid with another of the polymerized ethylene-unsaturated monomer, preferably methylviologen ether/maleic anhydride having a molecular mass (MM) from about 30,000 to about 1,000,000, most preferably from about 30,000 to about 800,000. These copolymers are available for example under the brand names Gantrez, for example, 139 (MM 500000), 119 (MM 250000) and preferably S-97 pharmaceutical grade (MM 700000), by ISP Technologies Inc. Bound Brook, N.J. 08805. Tools-amplifiers in the if any are present in an amount of from about 0.05 to about 3% of the weight.

Other existing polymers include 1:1 copolymer of maleic anhydride with acrylate, hydroxyethyl methacrylate, N-vinyl-2-pyrrolidone or ethylene, and the ethylene, for example, available under the brand names Monsanto EMA No. 1103 MM with 10,000 and EMA grade 61, and 1:1 copolymer of acrylic acid with methyl or hydroxyethyl-methacrylate, methyl - or acrylate, isobutyl vinyl ether or N-vinyl-2-pyrrolidone.

Suitable are generally polymerized alafinova - or ethylene - unsaturated carboxylic acids containing an activated carbon-carbon olefinic double bond and at least one AC is boxallow group, that is, the acid containing an olefinic double bond, which is easily polymerized in the presence in the molecule of the monomer as in the alpha-beta position relative to the carboxyl group or as part of a terminal methylene group. Examples of such acids are acrylic, methacrylic, etakrinova, alpha goracinova, CROTONALDEHYDE, beta-aryloxy-propionic, sorbic, alpha chlorobionta, cinnamon, beta-stellacreasy, Mukanova, Takanawa, Tarakanova, musicanova, glucagonoma, konitova, alpha phenylacrylate, 2-benzylacrylamide, 2-cyclohexylaniline, angelic, umbilicata, fumaric, maleic acids and anhydrides. Various other olefinic monomers, copolymerisate with the specified carboxylic monomers include vinyl acetate, vinyl chloride, dimethylmaleic and the like. The copolymers contain suitable group of carboxylic salts the solubility in water.

An additional class of polymeric means includes a composition containing homopolymers of substituted acrylamides and/or homopolymers of unsaturated sulfonic acids and their salts, in particular, polymers based on unsaturated sulfonic acid selected from acrylamidoglycolate sulfonic acids, such as 2-acrylamide-2-methylpropane-sulfonic acid with a molecular weight of from about 1000 to about 2000000, which is automatically written in U.S. patent No. 484284727 from June 1989 author Zahid, included in the present invention by reference.

Another useful class of polymeric means includes polyaminoamide, in particular, contains the proportions of anionic surface-active amino acids such as aspartic acid, glutamic acid and phosphoserine, according to the disclosure of U.S. patent No. 4866161 authors Sikes et al., which is included by reference in the present invention.

Sometimes for the manufacture of compositions for the care of the oral cavity it is necessary to add a thickening agent to achieve the desired consistency, or stabilize or strengthen the action of the formulation. In some embodiments, the implementation of thickeners are carboxyvinyl polymers, carrageenan, hydroxyethyl cellulose and water soluble salts of cellulose ethers such as sodium carboxymethylcellulose and sodium karboksimetiltselljuloza. You can also include resins of natural origin, such as karaya, gum Arabic and tragacanth resin. Colloidal magnesium-aluminum silicate or tankodesantniki silicon can be premanent as a component of the composition of a thickening agent to further improve the texture of the composition. In some embodiments, the implementation of the use thickeners in amounts of from about 0.5% to about 5.0% of the total weight of the composition.

Enzymes

Compositions for the care of Rotova the cavity according to the invention can also optionally include one or more enzymes. Useful enzymes include any of the available enzymes: protease, glucanohydrolase, endoglycosidase, amylase, Athanasy, lipase and mucinase or compatible mixtures of these enzymes. In some embodiments, implementing the enzyme is a protease, dextranase, endoglycosidase and athanasou. In another embodiment, the enzyme is papain, an endoglycosidase, or a mixture of dextranase and atanazy. Additional enzymes suitable for use in the present invention are disclosed in U.S. patent No. 5000939 authors Dring et al., in U.S. patent No. 4992420; in U.S. patent No. 4355022; in U.S. patent No. 4154815; in U.S. patent No. 4058595; in U.S. patent No. 3991177 and in U.S. patent No. 3696191, all of which are included in the present invention with reference. The amount of enzyme in a mixture of several compatible enzymes in the present invention is from about 0.002% to about 2.0% in one embodiment, or from about 0.05% to about 1.5% in another embodiment, or in another embodiment from about 0.1% to about 0.5%.

Water

Water may also be present in the compositions for the oral cavity according to the invention. The water used for the manufacture of selling songs for maintenance of the oral cavity must be deionized and does not contain organic impurities. Water is usually the rest of the songs and sod Ritsa in amount from about 10% to about 90%, from about 20% to about 60%, or from about 10% to about 30% by weight of the compositions to the oral cavity. The specified amount of water include the free water which is added plus the amount which is introduced with other agents, for example sorbitol or any components of the present invention.

Moisturizers

In some embodiments, implementation of the composition for the care of the oral cavity is also desirable to include a moisturizer to prevent the hardening of the composition when exposed to air. Some moisturizing agents can also give the compositions of toothpaste desired sweet taste or flavor. In the composition of toothpaste moisturizer on a net basis moisture normally included in an amount from about 15% to about 70% in one embodiment, or from about 30% to about 65% in another embodiment, the weight of the composition.

Suitable humectants include edible polynuclear alcohols, such as glycerin, sorbitol, xylitol, propylene glycol, and other polyols and mixtures of these humidifiers. A mixture of glycerin and sorbitol can be used in some embodiments of the implementation as a moisturizing component of the toothpaste compositions of the present invention.

In addition to the above described components of the embodiments of the present izaberete the Oia can contain a variety of additional components toothpaste, some of which are described below. Additional components include, without limitation, for example, adhesives, foaming agents, flavouring tools, sweeteners, additional funds against flying, abrasive and dyes. These and other additional components are additionally described in U.S. patent No. 5004597, Majeti; in U.S. patent No. 3959458 Agricola et al. and in U.S. patent No. 3937807 Haefele, all of which are included in the present invention by reference.

The manufacturing methods

The compositions of the present invention can be produced using methods generally accepted in the field of products for the mouth.

In one exemplary embodiment, the composition for the care of oral cavity produced by neutralization or partial neutralization of arginine in a gel phase with acid, for example phosphoric acid, hydrochloric acid or carbonic acid, and mixing to form premix I.

Active means, such as, for example, vitamins, cetylpyridinium chloride (CPH), fluoride, abrasives, and any other desired active components are added to the premix I and mixed to obtain a premix II.

If the final product is a toothpaste, a premix type II basis for toothpaste, such as dicalcium phosphate or silicon, and mix. The final liquid mass is formed into a product for uhoduza oral cavity.

The use of a composition

The present invention regarding the method comprises applying to the oral cavity a safe and effective amount of the described compositions.

Compositions and methods according to the invention are useful for a method of protecting teeth, which causes them to promote recovery and remineralization, in particular to reduce or stop the formation of dental caries, reduce, or prevent demineralization and acceleration remineralization of the teeth, and reduce tooth sensitivity and reduction, recovery or prevent early damage to the enamel, for example, detected by quantitative light fluorescence (QLF) or electrometric method for the determination of caries (ECM).

Quantitative light fluorescence represents the visible light fluorescence, which can detect early damage and continued to monitor their progress or regress. Normal teeth fluoresce in the visible spectrum of light: when demineralization of the teeth of such phenomenon is not observed or it is detected to a lesser extent. Zone of demineralization can be quantified, and can control its development. To cause autofluorescence teeth, use a blue laser beam. In demineralized zones mark the lower fluorescence is, and they seem to be more dark in comparison with healthy tooth surface. For the quantitative determination of fluorescence from white spots or area/volume that is associated with damage to use the software. In General, subjects with identified damage in the form of white spots become research participants. The measurements were carried out in vivo with real teeth. Area/volume of damage measure in early clinical trials. Decrease (improvement) of the area/volume of damage is measured in the end, after 6 months of use of the product. Data is often presented as the percentage of improvement compared to the original state.

Electrometric method for the determination of caries (ECM) is a technique for measuring the mineral content of the tooth based on electrical resistance. Electrical conductivity measurements based on the fact that the fluid-filled microtubules are subjected to demineralization and destruction of enamel, electric current is passed. With the loss of minerals in the tooth decreases the resistance to electric current due to the increase of porosity. Therefore, the increase in the conductivity of the patient's teeth may indicate a demineralization. Typically, studies conducted at the surface of the roots with an existing lesion. The measurements were carried out in vivo on these teeth. To determine the changes electr the ical resistance before treatment and after 6 months of treatment. In addition, conduct a classical calculation of caries on root surfaces using tactile exploration. Hardness is classified on a scale of three items: a hard, leathery or soft. When measuring the ECM in the study of this type, the results are usually presented as indicators of electrical resistance (preferably higher) and data hardening in the affected area on the basis of the scale tactile test.

Thus, the composition of the invention are useful for reducing early lesions of the enamel (which is determined using QLF or ECM) compared to the composition with insufficient amount of fluorine and/or arginine.

The composition according to the invention are additionally useful for reducing harmful bacteria in the oral cavity, such as ways to reduce or stop the development of gingivitis, decrease the amount of acid produced by the bacteria, increasing the relative content of alginolyticus bacteria, stopping the formation of microbial biofilms in the oral cavity, improve and/or maintain after sugar load pH in the plaque of at least about 5.5, to reduce the accumulation of plaque and/or cleaning of teeth and mouth.

Finally, by raising the pH level in the mouth and obstacles to the growth of pathogenic bacteria composition according to the invention are useful for the scortia healing ulcers and wounds in the mouth.

Strengthening the oral health also provides health benefits for the body as a whole, since the tissues of the mouth may be the gateway for systemic infection. A healthy condition of the oral cavity associated with the health of the organism, as a whole, including the health of the cardiovascular system. Compositions and methods of the invention are particularly useful as basic amino acids, particularly arginine, serve as a source of nitrogen, which provides a path of NO synthesis and thus improves microcirculation in the tissues of the oral cavity. Achieving a less acidic environment in the mouth is also helpful to reduce gastric upset and creates an environment less conducive to Helicobacler, which is associated with stomach ulcers. Arginine is especially required for high expression of specific receptors of immune cells, such as receptors of T-cells, i.e. arginine may enhance effective immune response. Thus, the compositions and methods of the present invention is useful for improving the health of the whole body, including the health of the cardiovascular system.

Compositions and methods according to the invention can be included in the compositions for the care of mouth and teeth, such as tooth pastes, transparent pastes, gels, liquids for mouth rinses, sprays and chewing gum.

Used everywhere the present invention ranges used for brief descriptions of each value within the range. Any value in the range can be selected as a limit of the range. In addition, all references cited in the invention, incorporated in it by reference in its entirety. In the event of a conflict between the concepts of the present disclosure and the concepts of cited references control is disclosed. Assume that in the description of the formulations can contain a description in terms of their components, which is common in the art, although these components can react with each other in the actual recipe in its manufacture, storage and application, and such products are included in the scope of the described formulations.

The following additional examples describe and illustrate examples of embodiments within the scope of the present invention. The examples are given solely for illustration and should not be construed as limitations of the present invention, as many changes may be made without departure from the essence and scope of the invention. Various modifications in addition to the shown and described in the present invention are obvious to a person skilled in the art and are included in the scope of the attached claims.

EXAMPLES

Example 1

The absorption and delivery of antibacterial agents in formulations with Argi is another

Formulations were made using selling toothpaste that contains, i.a., 0.3% of the weight of triclosan, 0,243% weight of sodium fluoride, sodium lauryl sulfate and a copolymer metilfenidato ether and maleic anhydride (PVM/MA), which was added to 0.1%, 3% and 5% L-arginine hydrochloride (pH 7,0).

The inclusion of L-arginine in the composition of the commercial formulation increases the amount of soluble triclosan, absorbed from the formulation, from about 70% (0% arginine) to about 80% (1% arginine), 85% (3% arginine) and 95% (5% arginine).

Formulations tested in vitro in an artificial model of the oral cavity, designed to measure attachment of bacteria to hydroxyapatite (HAP) disks treated with toothpaste within 24 hours, in General, as described Gaffar, A. et al. American Journal of Dentistry, vol. 3. September 1990, with modification, when covered with saliva hydroxyapatite disks were treated liquid mass toothpaste before bacteria. It is shown that the inclusion of L-arginine in the composition of the commercial formulation enhances delivery of triclosan to drives up to about 50%, while increasing grip at the point of time of 30 minutes, from about 40 μg triclosan in the control disk up to about 60 μg triclosan with formulation 5% arginine. After 24 hours, the control disks were kept about 10 μg per disc, compared with approximately 20 μg 5% formulation of arginine, which is significantly higher. Similar to the results of ostinati using histidine or lysine instead of arginine.

This increased shipping directly leads to increased antibacterial effect of the formulation with a statistically significant reduction of approximately 15% inhibition of growth of A. viscosus when applying a 5% formulation of arginine compared to control.

Example 2

Preparation containing arginine formulations based on silicon

Formulations of toothpaste containing 5% arginine in silicon-based, made as follows.

The solution premix (premix (I) was prepared by dissolving sodium fluoride and saccharin sodium in the number of H2O in the recipe. In a separate container was dispersible polymer resin and titanium dioxide in a moisturizing agents. Added premix I to the gel phase and heated if necessary.

Made another premix solution (premix II) by the first dispersion of L-arginine in part of the water from the formulation. A mixture of PVM/MA (Gantrez) was then added to the dispersion of L-arginine and mixed to a homogeneous state. Then the pH of the gel phase can be adjusted to neutral pH by adding an appropriate quantity of inorganic acid or base. Then the premix II was added to the humidifier/solution polymer resin to complete the gel phase.

The gel phase was transferred into a suitable vessel for production. To the phase of the gel was added to the abrasives and the MCA is ivali under vacuum until homogeneous. Finally, to the mixture was added triclosan, flavor and surfactant and mixed under vacuum until homogeneous.

Formula composition: Triclosan plus L-arginine

Content% weight/weight
Sorbitol is not darkening/not crystallizable20,85
99,0%-101,0% Vegetable glycerin - USP and EP20,0
Gantrez S-972,0
Dental silicon-Zeodent 105-silicon wysokosciowe properties10
Dental silica (Zeodent 115) abrasive8,5
L-arginine5,0
Dental silicon Zeodent 165 - synthetic amorphous silicon Ppt3,0
Powder - sodium lauryl sulfate NF1,5
A solution of 50% sodium hydroxide (sort of reagent)1,2
Sodium CPH-12 type USP1,1
Flavor1,0
Hydrochloric acid0,9
Titanium dioxide USP0,75
Propylene glycol - USP0,5
Carrageenan (LB 9505)0,40
Triclosan - USP0,3
Sodium saccharin USP0,3
Sodium fluoride USP0,243
Demineralized waterQs

Additional formulations were made as follows.

Example 3

The effectiveness of the formulations in the absorption of triclosan and accession bacteria

Investigated the capture of triclosan by applying a liquid mixture of toothpaste covered with saliva hydroxyapatite disks within the set time when 37º. The disks were rinsed to remove excess toothpaste on the surface. Active tool that was applied to the disk, then was dissolved and analyzed by high-performance liquid chromatography (HPLC). Commercial toothpaste, is within a recipe, similar to the compounding formula II of example 2 above, contains, i.a., 0.3% of the weight of triclosan, 0,243% weight of sodium fluoride, sodium lauryl sulfate and a copolymer metilfenidato ether and maleic anhydride, but without arginine, is a reliable running. Specified, the positive control had a seizure triclosan to 32.7 μg per disk compared to the capture of the formula II 58,8. A product with arginine thus there is intelligence that 79.8% higher than the commercial formulation.

Test against accession. Formula II (decrease 0,1845) shows the results higher than the positive control (triclosan without arginine, decrease 0,1809) with light, unexpressed border, and formula I (arginine without triclosan, decrease 0,1556) with a wider border. Antibacterial test. Formula II (decrease 0,1980 reduction) benefits from reliable control (decrease in 0,1789) and formula I (decrease 0,1891).

Example 4 delivery of antibacterial agents in formulations containing precipitiously calcium carbonate

Formulations containing 2% arginine bicarbonate, produced as follows.

The formula A

SHODY MATERIAL% WEIGHT
Deionized water32,420
70% sorbitol23,000
Carboxymethylcellulose0,940
Xanthan gum0,210
Saccharin sodium0,450
Sodium silicate0.800 to
Sodium bicarbonate0,500
The arginine bicarbonate2,000
Precipitiously calcium carbonate36,000
Monitoroff sodium0,760
Flavor1,000
Triclosan0,300
Sodium lauryl sulfate1,620
The TOTAL NUMBER of100,000

The formula

SHODY MATERIAL% WEIGHT
Deionized water23,200
70% sorbitol23,000
Xylitol2,500
Carboxymethylcellulose0,940
Xanthan gum0,210
Saccharin sodium0,450
Sodium silicate0.800 to
Sodium bicarbonate0,500
The arginine bicarbonate2,000
Precipitiously calcium carbonate42,000
Monitoroff sodium1,100
Flavor1,000
Triclosan0,300
Sodium lauryl sulfate2,000
The TOTAL NUMBER of100,000

Formula C

SHODY MATERIAL% WEIGHT
Deionized water34,420
70% sorbitol23,000
Carboxymethylcellulose0,940
Xanthan gum0,210
Saccharin sodium0,450
Sodium silicate0.800 to
Sodium bicarbonate0,500
The arginine bicarbonate0,000
Precipitiously calcium carbonate36,000
Monitoroff sodium0,760
Flavor1,000
Triclosan0,300
Sodium lauryl sulfate1,620
The TOTAL NUMBER of100,000

In the test of capture described in the above examples, the formula And demonstrates 57,86 μg triclosan on disk compared to 22,88 mcg with formula C (control without arginine)./p>

Example 5

Recipe liquid mouth rinse

Recipe liquid mouth rinse of the present invention produced using the following components.

Liquid for rinsing with arginine containing fluoride and triclosan

SHODY MATERIAL% WEIGHT
Deionized waterq.s.
Glycerin15,000
Sodium methyl, Cocoyl taurate0,250
95% ethanol6,000
Sodium lauryl sulfate0,200
Allantoin0,110
Sodium benzoate0,100
The sodium salicylate0,100
Sodium fluoride0,050
Saccharin sodium0,005
Triclosan0,030
Phosphoric acid 85% 0,120
L-arginine0,300
Flavor0,100
Dye0,001
PVM/MA0,250
The TOTAL NUMBER of100,000
The pH level7,0

Example 6

Recipe toothpaste containing precipitiously calcium carbonate (GAC)

Group testing consumers trained to test sensory characteristics of formulations of toothpaste, used different formulations of toothpaste, which was used under conditions of double-blind consumer test, copying the application of consumers formulations of toothpaste.

The group has traditionally asked to apply toothpaste different recipes and then evaluate the different sensory attributes. For the basic recipe toothpaste containing precipitiously calcium carbonate (GAC), a well-known recipe served as a control as a placebo, and also tested the corresponding formulations, optionally containing 1, 2, 3, or 5% of the weight of arginine bicarbonate. It was unexpectedly found that contains the arginine bicarbonate Retz is ptory PAC showed increased acceptance by the consumer by reason of the intensity of the fragrance, cooling properties and ease of foaming, and, in addition, formulations, optionally containing 2% by weight of arginine bicarbonate, demonstrated increased overall positive assessment, when in General liked the taste, the taste for cleaning and taste after cleaning. Additionally, formulations, optionally containing arginine bicarbonate, was perceived to be significantly better than the placebo control on all measured characteristics, including the perceived efficacy, the sense of purity in the mouth/teeth, acceptability of the product, the taste and overall quality of the product.

On the other hand, when testing of formulations based on dicalcium phosphate, and not on the basis precipitating calcium carbonate (GAC), noted that the addition of arginine bicarbonate does not show significantly improved sensory characteristics compared to the same formulation without the addition of arginine bicarbonate.

This example shows that the addition of basic amino acids such as arginine, in particular in the form of bicarbonate, may enhance the sensory characteristics of the formulations of toothpaste, to the greatest extent with the recipe based on precipitating calcium carbonate (PAC), when used in compositions for the care of the oral cavity of the present invention.

Example 7

Basic amino acids other than arginine

Cultures Of The S. sanguis during the night were incubated at 37°C in trypticase-soy broth (Becton Dickinson. Sparks, MD). The culture was centrifuged at 5000 rpm for 5 minutes in a one-time amount of 1 ml in a pre-weighed test tubes to collect about 5 milligrams of the weight of wet debris. Then debris resuspendable 20 mmol potassium phosphate buffer (JT Baker, Phillipsburg, NJ) with urovnem pH of 4.0 to simulate a stressful environment for bacterial cells, which will produce ammonia for survival. The final concentration was 5 milligrams per milliliter. To this end concentration) was added L-arginine, L-citrulline or L-ornithine in final concentrations of 5 mmol together with the final concentration of 0.1% sucrose (VWR. West Chester. PA). Before determining the production of ammonia the mixture incubated at 37°C in a water bath shaker for 30 minutes.

For the analysis of ammonia used test kit for ammonia firm Diagnostic Chemicals Limited (Oxford, CT). The specified set is intended for the quantitative analysis of in vitro ammonia in the plasma, but the technique was modified to identify and quantify the production of ammonia in the plaque and/or bacteria.

The table below shows the production of ammonia in 6 separate trials using S. sanguis at pH 4.0, as described above. The results confirm that an intermediate product is s, generated by the system deiminase arginine, can be premanent for the production of ammonia for cell survival.

This example shows that the basic amino acids other than arginine, effectively produce ammonia in the oral cavity and, thus, increase the pH of the plaque when used in compositions for the care of the oral cavity of the present invention.

1. Composition for the care of oral cavity, containing:
arginine, in free form or in salt form in an amount of from 0.1 to 20 wt.% the total weight of the composition;
triclosan in an amount of from 0.01 to 5 wt.% the total weight of the composition,
anionic polymer which is a copolymer metilfenidato ether and maleic anhydride,
anionic surfactant in an amount of from 0.01 to 10 wt.% the total weight of the composition,
soluble fluoride salt in an amount of from 0.01 to 2 wt.% the total weight of the composition, or the ion source of fluoride in quantity, to ensure 50-25000 hours/million by weight of fluoride ions, which are soluble fluoride salt or a source of fluoride ions selected from sodium fluoride, monophosphate sodium and mixtures thereof, and
abrasive material, which contains a small fraction of the particles constituting at least about 5 wt.% the total weight of the composition, and at the specified fraction of the small particles have an average diameter d50 IU is 5 microns.

2. The composition according to claim 1, in which the fraction of small particles optionally is at least about 20 wt.% the total weight of the composition.

3. The composition according to claim 1, in which the salt of arginine selected from arginine phosphate, and arginine bicarbonate and arginine hydrochloride.

4. The composition according to claim 1, in which triclosan is present in an amount of from 0.01 to 1 wt.% the total weight of the composition.

5. The composition according to claim 1, containing anionic surfactant in an amount of from 0.3 to 4.5 wt.% the total weight of the composition, in which the anionic surfactant is optionally selected from sodium lauryl sulfate, sodium Laureth sulfate, and mixtures thereof.

6. The composition according to claim 1, in which the abrasive material is selected from calcium carbonate, silicon dioxide and mixtures thereof or material in the form of particles selected from silicon dioxide and calcium carbonate.

7. The composition according to claim 1, which is a toothpaste.

8. The composition according to claim 7, further containing xylitol.

9. The composition according to claim 1, in which abrasion of dentin by radioactive method (RDA) is less than about 150.

10. The composition according to claim 1 in the form of toothpaste, which additionally contains one or more components of water, abrasives, surfactants, foaming agents, vitamins, polymers, enzymes, moisturizers, thickeners, antimicrobial agents, preservatives, aromatic is tori, dyes and/or combinations thereof.

11. The use of a composition according to any one of claims 1 to 10 for maintenance of the oral cavity with a view to:
a. reducing or inhibiting the formation of dental caries,
b. reduce, repair or inhibit early damage to the enamel,
c. reduce or inhibit demineralization and acceleration remineralization of the teeth,
d. reduce hypersensitivity of the teeth,
e. reduce or inhibit gingivitis,
f. promote healing of ulcers and wounds in the mouth,
g. reduce the number of bacteria that produce acid,
h. increasing the relative content of alginolyticus bacteria,
i. to prevent the formation of microbial biofilms in the oral cavity,
j. improve and/or save after sugar load values plaque pH at least at the level of pH 5.5,
k. reduce plaque formation,
n. strengthening health in General, including the health of the cardiovascular system, for example, by reducing common infection through the tissues of the mouth,
R. formation stability or protection of the teeth against cariogenic bacteria; and/or
q. brushing your teeth and mouth.



 

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2 tbl, 1 ex

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16 cl, 1 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to oral care compositions and methods for using them. The presented oral care composition contains an effective amount of arginine bicarbonate and a fine particle fraction containing at least 5 % of the formulation weight. The particles in the fine particle fraction have d50 less than approximately 5 mcm with the fine particle fraction specified in deposited calcium carbonate, silicone dioxide and their mixtures. The composition may be used, in particular, for improved dentin defect closure in the patient's oral cavity. A version of the composition to be applied in treating sensitive teeth contains arginine bicarbonate and an abrasive substance specified in deposited calcium carbonate, silicone dioxide and their mixtures wherein the abrasive substance contains said fine particle fraction.

EFFECT: said composition oral care compositions and methods for using them are effective, including for tooth and oral cleansing, reducing or suppressing dental deposit accumulation, reducing a level of acid producing (cariogenic) bacteria, remineralising teeth, reducing or suppressing gingivitis, reducing dentin hypersensitivity.

38 cl, 1 tbl, 6 ex

Saliva substitute // 2472515

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely a saliva substitute. The egg white saliva substitute possessing the chemical, rheological and physiological properties analogous to those of natural saliva with the saliva substitute additionally containing at least one substance enabling regulating viscosity, and specified in: cellulose derivatives, gum resin, non-cellulose polymers or other polymers, e.g. hyaluronic acid or polyols. The use of the saliva substitute for deficient saliva compensation. The use of the saliva substitute for maintaining required residual oral moisture with deficient saliva. A packing containing the saliva substitute.

EFFECT: saliva substitute has the composition and the properties maximally approached to natural human saliva for maintaining required residual oral moisture with deficient saliva.

7 cl, 1 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to dentistry, and is intended for treatment of acute periodontodis. Preparation of carious cavity and mechanical and medicamentous processing of root canal are carried out. Sorbent SUMS-1, crushed to granule size 0.02-0.1 mm, is introduced into canal for a day. After sorbent removal 1% vilon solution is introduced into periapical tissues through canal for 3-5 minutes. After that, root canal is filled with paste, which contains calcium hydroxide, zinc oxide and 1% vilon solution in volume ratio1:1:0.5.

EFFECT: method ensures high treatment efficiency with reduction of remote disease consequences.

2 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: invention relates to cosmetology and represents hygienic preparation against foot sweat and smell, placed into hermetic packet from thermally welded material, in whose internal cavity placed are powder-like ingredients of hygienic preparation, placed into containers made from paper with polyethylene coating, or from film combined material, or from three-composite material paper-aluminium foil polyethylene, or from other similar material and manufactured with means of their opening in form of indication of packet opening direction and/or in form of perforation or perforations on the edge or edges of packet, characterised by the fact that is consists of two components: sodium hydrocarbonate and tannin - tannic substance, contained in plant Tamarix, in form of amorphous yellowish shiny powder, each of which is placed into individual package.

EFFECT: invention ensures reduction of sweat-production, increase of bactericidal, disinfecting and deodorising effects, does not induce allergic reactions if applied properly.

2 cl

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