Disinfectant

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medical microbiology and medicine, namely to disinfection, and may be used for preparing disinfectants for disinfection of the surfaces contaminated by microorganisms, medical, sanitary and microbiological equipment. The disinfectant contains hydrogen peroxide, a water suspension of silver nanoparticles and non-ionic detergent Triton X-100 in certain amounts.

EFFECT: invention provides improved microbicidal activity on vegetative and spore forms of microorganisms at the low concentrations of its ingredients.

4 dwg, 3 ex

 

The invention relates to the field of medical Microbiology and medicine, in particular to the chamber, and can be used to obtain the disinfectant with bactericidal and sporicidal activity with the purpose of decontamination of surfaces of medical, sanitary and microbiological equipment.

At the present time on the territory of the Russian Federation when designing disinfectants and compositions approved for use and are traditionally used as active substances the following chemical groups: galoidovodorodami, oxidants, surfactants, guanidine derivatives, phenolics, aldehydes, alcohols, acids, alkalis (Panteleyev L.G. Modern antimicrobial disinfectants. Main results and prospects of development of new tools // Disinfection. - 2005. No. 2. 49 - 56).

The most widely in disinfection practice are applied disinfectants based on chlorine, hydrogen peroxide, Quaternary ammonium compounds and aldehydes. Not detracting from the merits of each of these disinfectants should indicate existing problems associated with their use (to a lesser extent, related to hydrogen peroxide), namely, toxicity, environmental hazard, insufficient biocidal effect, a negative effect on the body human the ESA (Sevidov E.K., Roy I., Levitin DEATH, Comparative evaluation of corrosively modern disinfectants // farmakom. - 2003. No. 2. - C.2-4; Smirnov, A.M., Talanov GA Dioxins: sanitary and Toxicological value // veterinary medicine. - 1999. No. 9. 49 - 51; Sokolova NF Modern problems of organization and disinfection in hospitals to prevent nosocomial infections // Disinfection. - 2005. No. 4. - Pp.31-39). In this regard, there is still a problem of creating and searching for new active substances to obtain disinfectants with improved performance characteristics. The majority of new disinfectants are the traditional composition of active substances from different chemical groups in different ratios.

Hydrogen peroxide is traditionally used as a disinfectant. Having a high chemical activity and ability to form active radicals, hydrogen peroxide has a pronounced bactericidal effect on microorganisms at high concentrations (Shamb U., Setterfield o'clock, Wentworths C. the hydrogen Peroxide / Lane. from English. - M.: Foreign literature, 1958. - 586 C.). Low concentrations (0.1 to 1.0%) will not cause the rapid death of microorganisms. Usually as disinfectants used solutions of hydrogen peroxide at a concentration of 3-6% current substance (Without the danger of working with microorganisms I-II pathogenicity groups (hazard): SP 1.3.1285-03 / state sanitary and epidemiological supervision of Russia. - Appr. 25.06.2003. The security microorganisms III-IV groups of pathogenicity (danger) and agents of parasitic diseases: JV 1.3.2322-08 / state sanitary and epidemiological supervision of Russia. - Appr. 29.01.2008). So, in the composition of the disinfectant (RF Patent No. 2286145. Disinfectant) along with alkyldimethylbenzylammonium 20,0-22,5 (hereinafter wt.%), benzotriazole - 3,0-5,0, monohydroxy alcohol 5,0-10,0 used hydrogen peroxide 5,0-10,0.

Other disinfectants, such as deconex FF, Lithofin, Katamin a, B, Alumina, Sterilium and others, though not contain peroxide, but constructed on the basis of alkyldimethylbenzylammonium and nonionic surface-active substances (surfactants) (Lithofin) or didecyldimethylammoniumchloride and nonionic surfactants (deconex FF), etc. are used in disinfection practice. At the same time, it should be recognized that these tools are not effective against spore-forming microorganisms have a high concentration of working solutions, long-term exposure. When the dilution of the disinfectant has been decreasing microbicides, including sporicidal action.

With the aim of increasing the activity of the disinfectant against spore-forming microorganisms, predohranenie broad-spectrum at low concentrations, improve environmental and operational security designed disinfectant (RF Patent No. 2395962. Disinfectant), which is simultaneously present Quaternary ammonium salt, glutaric aldehyde, ethyl alcohol, hydrogen peroxide with sulfanola and perftordekalina. The concentration of hydrogen peroxide in the specified disinfectant is 5.0 wt.% Enhancement of antimicrobial activity of the patented composition, the authors explain the mutual influence of the ingredients of the composition to each other, including through the use of performanceline, microparticles which provide transport complex microbial components of the disinfectant through the membranes in microbial cell.

Wide possibilities of transport of antimicrobial compounds in a bacterial cell provides nanotechnology. Regardless of the method of obtaining nanoparticles exhibit unique physical and chemical properties that are largely determined by the properties of individual molecules, than the properties of solid substances of the same composition (Kolesnikov Legal security, nanotechnology, production and use of nanomaterials and its importance for medicine // Nanotechnology and health. - 2009. No. 3(1). - P.10-17). High specific surface area (calculated with needinit mass) increases the chemical reactivity of nanoparticles. This can lead, in particular, to increase the production of free radicals and reactive oxygen species and further damage of biological structures microbial cells (lipids, proteins, nucleic acids). Given the high absorption and penetration ability of the nanoparticles, it may be used in mixtures with antimicrobial agents at lower concentrations under current chemical compound.

Environmental security, high bactericidal activity, knowledge and centuries-old use of silver is the most appropriate substance to obtain on the basis of silver nanoparticles. It is known that the toxic dose of silver for humans is 200 mg·l-1. In small doses (0.02 to 0.04 mg), silver shows the properties of the trace, increasing the efficiency of tissue respiration; when its content in the solution of 0.02-0.04 mg ml-1silver has immunostimulating effect. At a concentration of 0.01-0.08 mg ml-1and above silver exhibits antimicrobial activity against gram-positive and gram-negative bacteria, cocci, viruses, fungi, mycobacteria tuberculosis, worms. Colloidal silver at a concentration of 0.01 mg·ml-1has antibacterial activity against all tested microorganisms.

There are several patented disinfectant (atent of the Russian Federation No. 2179155. Disinfecting aqueous solution; RF patent №2187460. Concentrate disinfectant; RF patent №2361619. Concentrate disinfectant based on hydrogen peroxide with the inclusion of other ingredients, the most important of which are silver ions, silver salt, a soluble salt of silver, respectively, listed patented disinfectants. Closest to the claimed means disinfectant is an aqueous solution - prototype (Patent RF №2179155. Disinfecting aqueous solution containing silver ions, citric or acetic acid, hydrogen peroxide (6 claims), distilled water, energenie substances and optionally flavoring food (or food concentrate, or ammonia in all its possible variants, as reflected in the claims). Specified disinfectant aqueous solution, having a bactericidal action, is intended for disinfection of surfaces without prior preparation, and for the stabilization and preservation of food products (natural juices, for example). Hydrogen peroxide (6 claims) is included with the disinfectant aqueous solution at a concentration of 0.01 to 10.0 wt.%.

In common with the claimed disinfectant are hydrogen peroxide and silver as a chemical element. By contrast, the prototype of the inventive disinfectant is the absence in the composition of citric or acetic acid, other additives, excessive when applied in medicine and medical Microbiology. The final concentration of hydrogen peroxide in the inventive disinfectant 1%, and included in it the silver nanoparticles and the nonionic detergent Triton X-100 because of its specific properties provide synergenic with hydrogen peroxide biocidal effect.

The objective of the invention is to develop a disinfectant against vegetative and spore-forming microorganisms that retain antimicrobial activity at low concentrations of active substances, environmental and operational safety. The technical result that can be achieved using the proposed disinfectant, is that high antimicrobial activity against vegetative and spore-forming microorganisms is achieved at low concentrations of working solutions, short-term exposure during processing, conservation, environmental and operational safety.

This object is achieved in that the claimed sanitizer contains equal proportions of hydrogen peroxide and ultra-fine silver-containing water system, as well as surfactant:

PE is ekici hydrogen 2% aqueous solution 49,5 ml
aqueous suspension of silver nanoparticles49,5 ml
Triton X-1001.0 ml
pH5,6-5,8 EDM

The inventive composition contains a peroxide according to GOST 10929-76, aqueous suspension of silver nanoparticles (10-60 nm) at a concentration of 10 mg·l-1on THE other 9392-005-14189356-09, manufacturer : OOO "Fractal-M" (application for a patent of the Russian Federation. The method of preparation Hydrosol / Golubev V.I., Sleptsov CENTURIES, Tagansky, A.; applicant and patentee VLA. No. 2008125204/02: Appl. 23.06.2008; publ. 20.02.2010. - bull. No. 5; the Application for the patent of the Russian Federation. Device for producing nanoparticles of conductive materials / Babkin E.A., V.N. Golubev, Kolenkow I.A., Sleptsov CENTURIES and others; applicant and patentee V. Sleptsov.- No. 2010106444/22: Appl. 26.02.2010; publ. 27.05.2010. - bull. No. 15), Triton X-100 (production Chemtrans, St. Petersburg) as a nonionic detergent. As the aqueous environment of the use of distilled or demineralized, or drinking water according to GOST 6709-72 or GOST 2874-82.

The high antimicrobial activity of the claimed means associated with the inclusion in the composition consisting of an aqueous solution of hydrogen peroxide and aqueous suspension of nanoparticles of silver is, addition of the nonionic detergent Triton X-100, antimicrobial activity is associated with solubilization divalent cations and destruction of cell membranes of prokaryotes. Convergent different mechanisms of action of the reactive components of the proposed disinfectant alter the ultrastructure of microbial cells and spores of microorganisms, violate the permeability of the membrane structures, cease functioning enzyme complexes, provide synergenic bactericidal effect of the used components.

A disinfectant is a transparent liquid, safe for use, no irritants to the upper respiratory tract, skin, does not cause degradation of the treated surface and corrosion of metals.

Antimicrobial activity of the disinfectant is studied using laboratory strains of microorganisms of the genera Staphylococcus, Pseudomonas, Escherichia, Bacillus, Yersinia. Evaluation of disinfectant activity is conducted according to the methods adopted in the Russian Federation (suspension method, and the method Basevich test objects) in accordance with the methodological documents (instructions for determining bactericidal properties of new disinfectants No. 739-68; Shandala MG, Panteleev, G., Sokolova NF and other Methods of testing disinfectants for OC the NCI their safety and effectiveness. - M., 1998. - 72 S.; Shandala MG, Sokolova NF, Abramova I.M. and other Methods of study and evaluation of sporicidal activity of disinfectants and sterilizing means. MU 3.5.2435-09). In the evaluation of biocidal activity by suspension polymerization using cultures of microorganisms at a concentration of 1·109CFU·ml-1; when using methods Basevich test objects contamination test objects spend up to level 1·105CFU·cm-2. At the end of the exposition conduct the seeding of the investigated suspensions on solid nutrient medium (mastopathy agar, agar, Difco) by the method of serial tenfold dilutions and after cultivation under specified temperature conditions calculate grown colonies of microorganisms. To determine the concentration of microorganisms using optical turbidity standard of production gisk named after. Laurasia, Moscow, sterile isotonic solution of sodium chloride.

The study of the ultrastructure of bacteria and spores carried out using scanning electron microscope JEOL JSM-6510LV (Japan) under the following monitored parameters: accelerating voltage of 30 kV, a working distance of 10 mm; the focal spot size - 30%; vacuum mode - deep vacuum. Drugs consider when increasing 5000-13000 time.

Example 1.

Prepare disinfectant with the following qualitative soothes the NII components:

hydrogen peroxide 2% aqueous solution49,5 ml
aqueous suspension of silver nanoparticles49,5 ml
Triton X-1001.0 ml
pH5,6-5,8 EDM

Preparing a suspension of Staphylococcus aureus (S.aureus) in sterile isotonic sodium chloride at a concentration of 1·109CFU·ml-1. Make a prepared suspension of Staphylococcus aureus in a bottle with disinfectant to a final concentration of 1·108CFU·ml-1. Sampling conducted in 5, 20, 40 and 60 minutes Sowing samples after exposure to the disinfectant on a dense nutrient medium at 48 hours of incubation at 37°C. the testing Results of bactericidal action judged by the presence or absence of growth of Staphylococcus aureus on solid nutrient media in Petri dishes.

The inventive disinfectant has a pronounced activity against Staphylococcus aureus, causing the death of bacteria in 5 min after the start of exposure.

Example 2.

Prepare disinfectant with the following quantitative the ω ratio of components:

hydrogen peroxide 2% aqueous solution49,5 ml
aqueous suspension of silver nanoparticles49,5 ml
Triton X-1001.0 ml
pH5,6-5,8 EDM

Prepare a suspension of Pseudomonas aeruginosa (P.aeruginosa) in sterile isotonic sodium chloride at a concentration of 1·108CFU·ml-1providing the initial density concentration Basevich the test object 1·105·CFU·cm-2. Soak contaminated with Pseudomonas (Pseudomonas and Bacillus) basebya test objects, modeling process special handling of linen and suits of cotton fabric. At the end of the exposition of the interaction of bacteria contaminating basebya test objects, with disinfectant suspension of bacteria are plated on solid medium by serial tenfold dilution and after cultivation at 37°C to produce the counting of colonies formed by viable bacteria.

The inventive disinfectant has a pronounced bactericidal activity against Pseudomonas aeruginosa in the evaluation method basev the x test objects, starting with 5 min exposure.

Example 3.

Prepare disinfectant with the following proportions of components:

hydrogen peroxide 2% aqueous solution49,5 ml
aqueous suspension of silver nanoparticles49,5 ml
Triton X-1001.0 ml
pH5,6-5,8 EDM

Preparing a suspension of spores vaccine strain STI Bacillus anthracis B. sterile isotonic sodium chloride at a concentration of 1·109spores in 1 ml of the Working suspension of spores vaccine strain STI contribute in the disinfectant in the ratio of spore suspension: disinfectant 1:9. Obtained a working suspension is stirred by shaking, and then start timing of the experiment. At the end of each given exposure time (the beginning of the experiment, 10 min, 30 min, 40 min) take a sample of a suspension of spores, placed on a cover glass, dried and fixed in ethyl alcohol (on THE 6-09-1710-77). Prepared samples are examined using a scanning electron microscope JEOL JSM-6510LV (Japan). Summary data on the results of scanning microscopy dispute vacci the aqueous strain STI figure.

After 10 min observed the formation of conglomerate dispute with rupture of membranes and merge sporoplasm; disputes lose the ability to germinate. After 30 min gap membranes dispute with the formation of the "shadows" of the dispute, the output sporoplasm in the environment. After 40 min is destruction, separation membranes dispute and complete loss of viability.

The inventive disinfectant provides a high level sporicidal and bactericidal activity at low concentration of the working solution.

Disinfectant, characterized by inclusion in the composition of silver nanoparticles as catalysts biocidal processes, hydrogen peroxide, silver nanoparticles, surface-active agent in the following proportions of the components,ml:

hydrogen peroxide, 2%aqueous solution49,5
aqueous suspension of silver nanoparticles49,5
Triton X-1001,0,

pH of 5.6 to 5.8.



 

Same patents:

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EFFECT: efficiently used to disinfect or sterilise an object having a part made from aluminium-based metals.

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FIELD: medicine.

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Detergent sanitiser // 2448735

FIELD: chemistry.

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Disinfectant // 2440146

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to veterinary, in particular to preparations for disinfection of objects of veterinary supervision against disease-causing microbes. Disinfectant includes glutaraldehide, glyoxal, alkylmethylbenzylammonium chloride and water, alkyldimethylethyl-benzylammonium chloride and anionic surface active substance, with the following component ratio, (wt %): glutaraldehide 3.0-4.0; glyoxal 2.5-2.8; alkylmethylbenzylammonium chloride 3.0-4.0; alkyldimethylethylbenzylammonium chloride 4.0-5.0; anionic surface active substance 8.0-9.0; water to 1 l. With application of 2% concentration disinfectant, consumption 400-500 ml/m2 and 60-120 minute exposition complete disinfection of objects against pathogenic organisms is achieved, the same effect being obtained with 3-% concentration of preparation and impact during 30-60 minutes.

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2 tbl, 4 ex

FIELD: medicine, pharmaceutics.

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FIELD: medicine, pharmaceutics.

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Disinfectant // 2436304

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FIELD: chemistry.

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14 cl, 1 dwg, 17 tbl, 8 ex

FIELD: transport, package.

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19 cl, 18 dwg, 7 ex, 1 tbl

FIELD: chemistry.

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FIELD: medicine, pharmaceutics.

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1 tbl, 15 ex

FIELD: medicine, pharmaceutics.

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EFFECT: invention ensures increase of bactericidal and fungicidal activity with reduction of concentration of working solutions of preparation, extension of action spectrum, including action on mycobacteria.

4 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to sanitation and can be applied in food, medical, veterinary, processing industry. Invention can be applied for obtaining preparations for disinfection of surfaces in premises, sanitary-technical equipment, items patient care, claimed disinfection preparation can also be applied for disinfection and pre-sterilisation cleaning of products of medical purpose, for disinfection and processing hands of medical personnel. Disinfection preparation includes quaternary ammonium compound, boric acid and represents water solution of quaternary ammonium compound, as such it contains diethyldichloropropenylammonium chloride or diethyldiallylammonium chloride, with the following ratio of initial components, wt %: said quaternary ammonium compound - 1.2 wt %, boric acid - 2.3 wt %, water - the remaining part.

EFFECT: invention ensures increase of bactericidal and fungicidal activity with reduction of concentration of working solutions of preparation, extension of action spectrum, including action on mycobacteria.

4 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, particularly to ophthalmology, namely: to antibacterial lenses containing metals, as well as to methods for producing them. The method for producing an antibacterial lens containing a metal salt involves the stages: (a) preparation of a hard lens by a salt precursor, as well as (b) preparation of the lens produced at the stage (a) by a disperse additive specified in a group consisting of polyvinylpyrrolidone, polyvinyl alcohol, glycerol and polyethylene oxide, and a metal-containing agent specified in a group consisting of silver tetrafluoroborate, silver sulphate, zinc acetate, zinc sulphate, copper acetate, copper sulphate, silver nitrate, manganese sulphide, zinc oxide, zinc sulphide, copper sulphide, copper phosphate, silver nitrate, silver sulphate, silver iodate, silver carbonate, silver phosphate, silver sulphide, silver chloride, silver chloride, silver bromide, silver iodide and silver oxide. The other method for producing involves the stages (a) of preparation of a hard lens by a metal-containing agent, and a disperse agent, (b) preparation of the lens prepared at the stage (a) by a salt precursor. The antibacterial lens containing the metal salt is produced by said methods.

EFFECT: group of inventions provides producing the lenses with a decreased degree of opacity.

16 cl, 1 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to medicine and may be used in hospitals, polyclinics, resort institutions for high level disinfection and sterilisation. A method for preparing a disinfectant provides mixing of liquid ingredients in the form of two solutions immediately before use. One of the solutions contains, wt %: urea peroxyhydrate - 2-16; corrosion inhibitor Korantin PP - 0.5-2; chelating agent Trilon M Liquid - 0.5-2; sulphuric acid for making the pH value of the solution - 0.5-2; deionised water - the rest. The second solution contains, wt %: ethyl acetate - 20-40; acetic acid - 8-11; potassium bichromate 0.1-0.3; sodium silicate - 0.05-0.7; polyethylene oxide - 0.3-3; acetyl caprolactam - the rest. The relation of the first to second solutions makes 70:1 to 500:1.

EFFECT: group of inventions provide the high disinfecting properties of the product, anti-corrosion effect on steel, non-ferrous metals, chromium-nickel coatings; the agent has no damaging action of the objects to be treated, does not decolour cloths, does not fixes organic impurities, does not damage endoscopes and fibre optics, as well as reduces the solution concentration and exposition time on the treated objects.

3 cl, 1 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to antibacterial lenses, containing metals and methods of their obtaining. Method of obtaining antibacterial lens, containing metal salt, is characterised by a) stage of processing hardened lens with solution, containing salt precursor and b) processing of lens, obtained at stage a) with solution, containing metal-containing agent, where molar ratio of said metal-containing agent in its solution constitutes from 0.6 to 10.0.

EFFECT: invention ensures obtaining antibacterial lens with low content of opacity/Ag, which makes possible its long application with transparency, sufficient for user to be able to see through the lens clearly.

10 cl, 1 tbl, 1 dwg, 4 ex

Disinfectant // 2466743

FIELD: medicine.

SUBSTANCE: disinfectant containing a chlorinated derivative of isocyanuric acid and a gas-yielding mixture comprises a polymer ingredient specified in a group consisting of polyvinyl alcohol, polyacrylic acid and its copolymers, polyvinylpyrrolidone, water-soluble cellulose esters and their mixture in the following proportions, wt %: chlorinated derivative of isocyanuric acid 20-90, polymer ingredient 0.1-5, gas-yielding mixture - the rest. The gas-yielding mixture represents a mixture of base and acid ingredients. The base ingredient of the disinfectant contains alkaline or alkaline-earth salts of carbonic acid or their mixture. As the acid ingredient, the disinfectant contains organic acids, may contain anticorrosion additives, e.g. sodium benzoate, sodium nitrite, calcium formate, zinc compounds. The disinfectant may contain a builder that is a non-ionic surfactant on the basis of oxyethylated derivatives of alcohols, phenols or organic acids, complexons - salts of ethylenediaminotetraacetic acid, a neutral excipient, e.g. sodium phosphate, sodium sulphate, sodium tartrate, sodium acetate.

EFFECT: invention provides preparing the ready storage-stable disinfection solutions containing active chlorine.

6 cl, 15 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to field of medicine, in particular, to ophthalmology. Group of inventions relate to antibacterial lenses, which contain metals, and methods of there production. Antibacterial lens which contains metal salt, obtained by method (versions), which includes stages: (a) processing hardened lens by solution, which contains metal-containing preparation and efficient quantity of acid substance, where pH of claimed solution constitutes from 2 to 5; and (b) processing of lens from (a) stage with solution, containing, basically containing or consisting of salt precursor and efficient quantity of acid substance, where pH of said solution constitutes from 2 to 5.

EFFECT: group of inventions ensures obtaining contact lenses, which contain antibacterial medications of constant composition.

19 cl, 2 dwg, 2 ex

FIELD: chemistry.

SUBSTANCE: group of inventions relates to disinfection and sterilisation. The acidic liquid composition used is a liquid composition which contains (a) an acidic oxidant, (b) nitric acid or salt thereof and (c) at least one carboxylic acid selected from a group consisting of monocarboxylic acids, dicarboxylic acids and tricarboxylic acids, or salt thereof. In the disinfection and sterilisation method, the acidic liquid composition contains an acidic oxidant having an excellent corrosion inhibiting property (property of preventing rust, property of inhibiting formation of an oxide film) for aluminium-based metals even in acidic conditions, without affecting the appearance or function of such metals.

EFFECT: efficiently used to disinfect or sterilise an object having a part made from aluminium-based metals.

12 cl, 20 tbl, 4 ex

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