Antiseptic disinfectant

FIELD: medicine.

SUBSTANCE: invention relates to disinfectants. An antiseptic disinfectant contains the film-forming preparation iodopyrone containing 6-8% of active iodine and water, contains ethanol in the following proportions, wt %: iodopyrone - 1.0-1.3 (per active iodine basis), ethanol - 20, water - the rest. The antiseptic disinfectant represents a ready-to-use preparation presented in the form of a solution or a spray.

EFFECT: invention provides the qualitative and quantitative stability of the active substance in the easily water-washable disinfectant which does not stain and has a non-irritant, prolonged effect If kept in an unopened container, it has a shelf-life of 2 years from the date of manufacture.

3 ex

 

The invention relates to creating a disinfectant antiseptic, which, in particular, can be used as antimicrobial, disinfectant and sterilizing agent in carrying out various surgical and other manipulations requiring antiseptic skin treatment of the patient and/or medical personnel, for example, as a skin antiseptic for treatment of hand, operational processing and injection field, the elbow bends donors, as well as for sterilization of medical products, including surgical and dental instruments, rigid and flexible endoscopes, instruments.

Known for the preparation of iodine with ethyl alcohol solution of iodine alcohol-5%, of the following composition: 5 g of iodine, potassium iodide 2 g of water and alcohol 95% equal to 100 ml. Transparent red-brown liquid. Used topically as an antiseptic, irritating and distracting way in inflammatory and other diseases skin and also to handle the surgical field (Mashkovsky PPM Medicines, Moscow, New wave, 2000, PP 156).

The disadvantage of the solution of iodine alcohol-5% is tanning and cauterizing effect of infusion on body tissues and the development of hypersensitivity. Tincture of iodine cannot be applied directly to the wound surface and mucous oblock is, because the solution contains free iodine has a burning effect that can cause irritation and even necrosis of damaged tissues. In addition, after removal of volatile constituents, not the skin is not protective coating.

From iodine compounds most widely as an antiseptic and disinfectant use iodophor-complexes of iodine with the carrier. The most famous yodopiron and yogonet, in which the carriers are polyvinylpyrrolidone and sulfonate.

Known itonut. Iodine solution of complex surface-active substances with iodine. 1 l of a solution for external use contains iodine with 52.0 g of potassium iodide with 52.0 g of orthophosphoric acid 62,0 g, alkylsulfonate 249,72 g, distilled water - the rest. Is a dark brown liquid, foaming when shaken. Shelf life 1 year.

The medication possesses antimicrobial activity, provided that the content is not only iodine but also surface-active media. Active against Escherichia coli, Staphylococcus aureus, Proteus, Pseudomonas aeruginosa; also has fungicidal properties. Used only as an antiseptic for skin disinfection of the operative field, as a substitute of a solution of iodine and alcohol. To handle the surgical field source solution diluted 5 times boiled Il is sterile water. Without pre-wash the skin of the surgical field 2 times treated with sterile swabs moistened with 5-7 ml of Odonata (with the concentration of free iodine 1%) for at least 1 min Before suturing the skin is treated again with the same solution.

The main disadvantage of the solution Odonata is a relatively short shelf life - 1 year (Mashkovsky PPM Medicines, Moscow, New wave, 2000, str, Dictionary of medical preparations, 2005).

Known yodopiron, representing a mixture of a complex of polyvinylpyrrolidone with iodine and potassium iodide, is a yellow-brown amorphous powder, slowly soluble in water. Yodopiron used as a skin antiseptic in complex treatment of purulent wounds, hand surgeon, for disinfection of the operative field and processing of the elbow bends donors. Powder itaperuna contains (the best part) 9.4 g of iodine, 9.3 g of potassium iodide, 81.3 g of low-molecular polyvinylpyrrolidone medical 126002700 (Patent 2275203, the Method of obtaining antiseptic yodopiron, with priority dated 25.08.2004,).

Yodopiron used as 0.1%, 0.5% and 1% solutions as skin antiseptics in complex treatment of purulent wounds, hand surgeon, for disinfection of the operative field and processing of the elbow bends donors. For obetz is rivane the hands of the surgeon used a 0.1% solution, to handle the surgical field, surgical gloves and elbow bends donors and treatment of purulent wounds - 0.5% and 1% solutions. 1% solution (active iodine) is prepared in the pharmacy; 0.1% and 0.5% solutions get 1% solution immediately before use. Shelf life of 1% solution of not more than 2 months. and 10 days when cooking conditions in the pharmacy, 0.1% and 0.5% several days (Mashkovsky PPM Medicines, Moscow, New wave, 2000, str).

The main disadvantage of the drug is its instability. The long-term solution must not be stored. It should have a dark brown color. Discoloration of the solution indicates the destruction of the complex with the transition of active iodine in the iodide-ion and reducing the effectiveness of the drug. Processes for the preparation of solutions of itaperuna require prolonged mixing and curing, as the powder itaperuna slowly dissolves in the water, before use, a need arises for dilution to the desired concentration of the solution.

It is known that iodine preparations and, in particular, his alcoholic solutions until the best antiseptics. The mechanism of antimicrobial action of these drugs are very similar: both, under certain conditions, produce atomic oxygen and the elements themselves are bactericidal.

The choice of disinfectant antiseptic preparato is determined by such basic factors as the effectiveness of antiseptics against pathogens (antimicrobial activity) and the sensitivity of the skin and skin reactions. These requirements are met by the products on the basis of ethyl alcohol. The disinfectants based ethanol has several advantages relative to similar drugs on the basis of isopropyl and propyl alcohols. The main disadvantages of such drugs is that these alcohols inactive against resistant forms of the virus are unpleasant, many unbearable odor, damaging to the skin, toxic if inhaled.

Disinfectants antiseptic preparations based ethanol carefully affect the skin. This is due to low toxicity of ethyl alcohol, with minimum processing time, which is important for an antiseptic, microorganisms does not occur to ethyl alcohol resistance, it acts on all sustainable types of viruses and microorganisms. Does not cause allergies.

The basis of the present invention, the task is to expand the range of ready-to-use disinfectant iodine-containing antiseptic funds with not irritating, prolonged effect, the dosage form in the form of a solution and spray.

This object is achieved in that the antiseptic disinfectant means is on, includes film-forming drug yodopiron with the concentration of active iodine 6-8% and water further comprises ethyl alcohol in the following ratio, wt.%: yodopiron - 1,0-1,3 (in terms of active iodine), ethyl - 20, water - the rest.

The technical result of the combination of the claimed features is not getting irritating antiseptic disinfectant with a lifespan of 2 years, in the nal dosage form.

The use of ethyl alcohol in the claimed means slows down the excretion of iodine, does not cause skin irritation when his long-term use. Has a bactericidal effect on gram-positive and gram-negative flora, does not cause skin irritation when his long-term use. Does not burn, even after prolonged contact delicate skin areas on the inner surface of the elbow bend and forearms, neck, face. The content of ethyl alcohol reduces the risk of allergic conditions of the staff. Iodine, which is in complex with polyvinylpyrrolidone, loses the ability to burn tissue, reduces irritating effect.

Patent search carried out by the scientific and technical literature, showed that the proposed set of distinctive features is unknown, i.e. the proposed remedy meets the criterion of "novelty."

The village is olcu comprises known components, it meets the criterion of "industrial applicability".

As a result of using this tool it is possible to use the proposed tool as a disinfectant and antiseptic, it meets the criterion of" inventive step".

The invention is illustrated by the following examples:

Example 1. To produce 1 kg of disinfectant antiseptic composition, wt.%: yodopiron - 1,0 (in terms of active iodine), ethyl - 20,0, water - the rest in the reactor with a stirrer to prepare a water-alcohol solution. For the preparation of 850 g of water-alcohol solution take 173.5 metric g ethanol 95% (Pharmacopeia 42-3072-00), purified water 676,5 g (Pharmacopeia 42-2619-97), stirred, gradually added with constant stirring 150 g of powder of the substance of itaperuna (Pharmacopeia 42-02106705-05) with a concentration of active iodine 6%, pH 2.0. 5-6 hours, stirred until dissolved, filtered.

Get brown, transparent liquid with ulterior specific smell, with a mass fraction of itaperuna active iodine and 1.0%, pH of 2.5. The quality indicators correspond to THE 9392-003-03344728-2011 Tool disinfectant, antiseptic "Yodopiron 1%Uiform".

Example 2. Download and run process recip is of disinfectant antiseptic analogously to example 1, only for the stated means of composition, wt.%: yodopiron - 1,2 (in terms of active iodine), ethyl - 20,0, water - the rest, take 150 grams of powder substance of itaperuna with the concentration of active iodine to 7.6%, a pH of 2.5. Get brown, transparent liquid with ulterior specific smell, with a mass fraction of itaperuna active iodine 1,18%, pH of 3.0.

Example 3. Download and run the process of obtaining a disinfectant antiseptic similarly to example 1, except for specified funds composition, wt.%: yodopiron - 1,3 (in terms of active iodine), ethyl - 20,0, water - the rest, take 150 grams of powder substance of itaperuna with the concentration of active iodine 8%, pH 3.5. Get brown, transparent liquid with ulterior specific smell, with a mass fraction of itaperuna active iodine to 1.3%, the pH of the solution to 4.5.

The results of disinfectant antiseptic, biocidal activity, toxicity and safety of use, and validity of the proposed funds are confirmed by TLC fgbu RIICO them. Ren Ministry Of Health Of Russia. Positive Expert conclusion from 21.11.2011,

Suggested disinfectant antiseptic "Yodopiron 1%Uiform" is a ready to use product, made in the form of a solution and spray features, is characterized by the constancy of qualitative and quantitative content of the active substance. Shelf life funds, provided it is stored in the unopened package is 2 years from date of manufacture. Resistant to external influences, comfortable in use. When applied to the visible skin areas (face, neck and other) easily washed off with water, does not leave stains.

It is established that disinfectant antiseptic for local application manifests bactericidal (against wide spectrum of gram-positive and gram-negative microorganisms, including antibiotic-resistant strains of Escherichia coli, Staphylococcus aureus and Proteus), fungicidal and anti-inflammatory effect, has virucidal activity. Maintains high antiseptic properties of iodine in the presence of blood, plasma, does not cause the development of resistant forms of microorganisms, has no allergic effect, non-toxic. Has prolonged antimicrobial activity at least 5 hours, retains its properties after freezing and subsequent thawing. Applies to low-risk, non-toxic compounds.

So, with hygienic treatment of hands proposed product is applied on the hands until dry, but not less than 1 minute. When processing the surgeon's hands, the product is applied twice (5 ml) before drying, processing time 5 minutes. When processing the skin of the surgical field, the elbow with ebov, skin before the introduction of catheters and punctures of joints, skin, double-wipe separate gauze swabs offer tools, stand for 2 minutes. Processing injected field, wounds, abrasions, insect bites is carried out by wiping abundantly moistened by means of a swab or irrigation of the skin at the injection site, wounds, bruises or bite. The exposure time after the end of treatment - 20 sec.

Suggested disinfectant antiseptic "Yodopiron 1%Uiform" can be produced without the use of special equipment and violations of environmental environment.

Developed industrial batch of the proposed tools.

Disinfectant antiseptic containing film-forming drug yodopiron with the concentration of active iodine 6-8% and water, characterized in that it further contains ethyl alcohol in the following ratio, wt.%:

Yodopiron1,0-1,3 (in terms of active iodine)
Ethyl alcohol20,0
WaterRest



 

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