Bactericidal medication

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to bactericidal medication and can be applied for disinfection of livestock premises, placed in them technological equipment, implements for animal care, vehicles for transportation of animals, places where animals and other objects of veterinary supervision are concentrated. Medication includes alkyldimethylbenzylammonium chloride (ADMBAC), glutaric aldehyde, water and sodium hydroxide, taken in specified ratio. In case of specified ratio synergetic effect is observed and maximal bactericidal activity of medication, assessed by value of minimal bactericidal concentration (MBC), at which death of test-culture is observed, is reached.

EFFECT: invention ensures increase of bactericidal activity and reduction of medication toxicity with minimal content of active substances.

1 tbl, 15 ex

 

The invention relates to agriculture and veterinary medicine, in particular to sterilizing agents containing Quaternary ammonium compound (QAC) and dialdehyde, and can be used for disinfection of livestock premises in technological equipment, equipment for the care of animals, vehicles for the transport of animals, places, animals and other objects veterinary supervision.

Known disinfectant for disinfection and sterilization of medical supplies Glutaral (HOWTO MU-287-113 approved 30.12.1998, Department of state sanitary epidemiological surveillance of the Russian Federation). The product contains 2.0 to 2.5% active substance glutaraldehyde and distilled or purified water. Glutaric aldehyde has a high bactericidal, virucidal, fungicidal and sporicidal effect that can be attributed to high level disinfectants.

The effectiveness of disinfectants evaluated for their antibacterial activity, determine the minimum bactericidal concentration (MBC)at which no growth of bacterial test cultures in a nutrient medium (instructions for determining bactericidal properties of new disinfectants. Decl. The USSR Ministry of health 06.05.1968, No. 739-68). For glutaraldehyde 0.5 MBq at exposure of 60 minutes

Known disinfectant "Katamin JSB for disinfection of equipment and surfaces of industrial premises in the dairy industry (Approved by the Head of the Department of state sanitary epidemiological surveillance of the Russian Federation 16.02. 1999, No. 1100/360-99-113). The product contains 50±1% alkyldimethylbenzylammonium chloride and drinking water. For disinfection are preparing an aqueous working solutions containing 0.15-0.20% of active substance. For alkyldimethylbenzylammonium chloride IBC is 0.02% at exposure of 60 minutes

Known disinfectant "Nosodes-50" for disinfection of surfaces in premises, sanitary-technical equipment, patient-care items and other objects in medical institutions, food service companies and utilities. The product contains the active substance of alkyldimethylbenzylammonium chloride (50%) and water. For disinfection prepare working solutions with a content of active substance from 0.03% to 3.0% depending on the object disinfection, methods of decontamination and exposure (instruction No. 006-2/2005 on the application of the disinfectant "Nosodes-50", JSC NPO Nosodes, Russia).

As seen from the above examples, working solutions for disinfection on the basis of alkyldimethylbenzylammonium chloride contain 10 times less active substance than on the basis of glutaric alder is Yes, what affects the cost of drugs, and environmental load. In addition, alkyldimethylbenzylammonium chloride is a surface-active substance and its solutions have a detergent action that helps remove dirt.

Known for a number of disinfectants, in which the active substances are mixed glutaric aldehyde and HOUR. According to the authors, the joint presence of disinfectants different mechanism of action should summarize their advantages and eliminate the disadvantages.

Known disinfectant containing glutaric aldehyde (20,0-26,0%), Quaternary ammonium compound type N-[alkylphenoxy(ethyleneoxy)carbonylmethyl]ammonium chloride particular composition (4,0-20,0)% and water (to 100%) [U.S. Pat. 2158140 of the Russian Federation. C2. A61L 2/16. 27.10.2000]. The minimum bactericidal concentration of the mixture of active substances, as defined by the test-culture of Staphylococcus aureus, is between 0.015% to 0.078% at exposure of 2 hours depending on the ratio of glutaraldehyde and HOUR. The maximum antibacterial activity has a composition containing about 21% glutaraldehyde and 17% an HOUR. As can be seen from the above data, the IBC proposed means, and means and bactericidal activity, practically does not differ from the IBC alkyldimethylbenzylammonium chloride at equally the Oh exposure. In addition, for making this tool requires an additional heating at 50-80°C for 2-3 hours.

Known means disinfectant containing alkyldimethylbenzylammonium chloride (25,0-35,0%), glutaric aldehyde (0,3-0,7%), glyoxal (3,6-6,5%), nonionic surfactant (surfactant) (4,0-8,0%), ethyl alcohol (6-10%), Trilon B (0.08 to 0.12%), and water (to 100%) [U.S. Pat. 2145238 of the Russian Federation. C1. A61L 2/18, 2/16. 10.02.2000]. For disinfection of water use working solutions with concentrations tools of 0.1-2.0%, depending on the object disinfection. The lower limit of the total content of active substances in the medium is 30%. The lower limit of the total content of active substances in the working solution is 0.03%. The minimum bactericidal concentration (MBC) of the mixture of active substances is 0.03% and practically does not differ from the IBC alkyldimethylbenzylammonium chloride (0,02%).

Known disinfectant containing alkyldimethylbenzylammonium chloride (1,6-2,0%)), glutaric aldehyde (1.4-1.8 percent), 1,4-butanediol (1,6-2,2%), nonionic surfactant (0,4-0,8%), perfume (0,01-0,05%), citric acid to create an acidic environment with a pH of 3.5-4.3 and water (to 100%) [U.S. Pat. 2203094 of the Russian Federation. C1. A61L 2/16, 2/18. 27.04.2003]. For disinfection of water use working solutions with concentrations funds 0.5 to 10.0% depending on the object disinfection. The lower limit of the total content of the activities of the respective substances in the medium is about 5%. The lower limit of the total content of active substances in the working solution is 0.025%. The minimum bactericidal concentration (MBC) of the mixture of active substances is 0.03% and practically does not differ from the IBC alkyldimethylbenzylammonium chloride (0,02%).

Known disinfectant containing alkyldimethylbenzylammonium chloride (3,0-15,0%), dialdehyde (2,0-12,0%), monohydroxy alcohol (0.5 to 10.0%), nonionic surfactant (1,5-5,0%), an aqueous solution of a buffer agent containing sodium tetraborate and hydrochloric acid or a mixture of phosphate salts of sodium and potassium to create a pH of 7.0 and 7.6 (100%) [U.S. Pat. 2190426 of the Russian Federation. C1. A61L 2/16, C11D 3/48, 10.10.2002]. In the examples were determined by the minimum bactericidal concentration of the proposed funds, which amounted to 0.05% of the drug is that even more MBq of alkyldimethylbenzylammonium chloride (0,02%).

Known disinfectant and sterilizing agent containing alkyldimethylbenzylammonium chloride (20,0-40,0%), glyoxal and/or glutaric aldehyde (0.4 to 12.0 percent), alcohol, C2-C4 (3,0-10,0%), hydrophilic nonionic surface-active agent (surfactant) (3,0-7,0%), Trilon B (0,2-1,2%), tributyl or tricresylphosphate (0,5-3,0%), hydrophobic nonionic surfactants (0,5-3,0%), functional additives (0.4 and 1.4%), water to 100% [Pat. 2272652 of the Russian Federation. C1. A61L 2/16, A61L 2/18. 27.03.2006]. In the examples were determined by the minimum bactericidal concentration before aguinaga means, which was 0.025%, which is almost equal to the IBC alkyldimethylbenzylammonium chloride (0,02%).

Known disinfectant containing alkyldimethylbenzylammonium chloride (20,0-22,5%), glutaric aldehyde (0,8-1,5%), benzotriazol (3,0-5,0%) hydrogen peroxide (5,0-10,0), monohydroxy alcohol (5,0-10,0), water (to 100%) [U.S. Pat. 2286145 of the Russian Federation. C1. A61K 31/14, A61K 31/327, A61K 31/11, A61K 31/045, A61L 2/16. 27.10.2006]. For the evaluation of bactericidal activity was tested aqueous solutions with a concentration of the means of 0.1 to 3.0%. The minimum bactericidal concentration (MBC) of the mixture of active substances is 0.1%, which is significantly more MBq of alkyldimethylbenzylammonium chloride (0,02%).

Known disinfectant containing alkyldimethylbenzylammonium chloride (10.0%), hydrogen peroxide (5,0%), ethyl alcohol (5,0%), glutaric aldehyde (0.5 percent), sulfonic acid (0.5 to 2.0%), perpendicular (0.2 to 1.0%), water (to 100%) [U.S. Pat. 2395692 of the Russian Federation. C1. A01N 25/02, A01N 27/00, A01P 1/00. 10.08.2010]. For the determination of bactericidal activity using aqueous solutions with a concentration of funds from 0.2 to 1.0% depending on the type of test culture. The lower limit of the total content of active substances in the tool is 21.2%. The minimum bactericidal concentration (MBC) of the mixture of active substances is 0,0424%, higher interbank lending, alkyldimethylbenzylammonium chloride (0,02%).

The closest in composition and purpose is known disinfectant means is Smack-surfactant for disinfection of objects veterinary supervision, containing alkyldimethylammonium chloride to 25%glutaric aldehyde - 25% water (instructions for use SMAC-surfactant for disinfection of objects of veterinary surveillance and prevention of infectious animal diseases. Decl. 08.07.2010, Deputy Head of the Rosselkhoznadzor).

The main disadvantage of disinfectants based on Quaternary ammonium compounds (QAC), which include alkyldimethylbenzylammonium chloride is ineffective against spores and simple viruses, lack of activity against gram-negative bacteria (Oparin PS, Tyurneva N.A., Peep, S.I. and other Disinfectology at the present stage // SC SC SB RAMS, Irkutsk, 2003).

The main lack of funds on the basis of glutaraldehyde is its relatively high concentration in the working solution and the negative impact on the skin, eyes and respiratory tract of staff due to its relatively high volatility. As a result, the Inspectorate for labour protection UK HSE since may 2002, has banned its use in hospitals. In addition, glutaraldehyde is characterized by fixation of protein contamination on treated surfaces that require additional processing to remove these contaminants.

The technical task of the present invention is the creation of microbicides povyshen the th bactericidal activity with a minimum content of active compounds in the working solution to ensure emission control means and reagent consumption.

The problem is solved in that the antibacterial agent containing alkyldimethylbenzylammonium chloride and glutaric aldehyde, optionally contains caustic soda in the following ratio, wt.%:

Alkyldimethylbenzylammonium chloride10,0-10,5
Glutaric aldehyde10,0-10,5
The caustic soda (sodium hydroxide)0,08-0,12
Water100

As alkyldimethylbenzylammonium chloride use Katamin AB, manufactured by CJSC SPC "Bursitis-M, RF, TU 9392-003-48482528-99, or Barkved DM-50, supplied by the firm Lonza AG, Switzerland, which is an aqueous solution containing 50±1% alkyldimethylbenzylammonium chloride.

As glutaraldehyde use Protectol® GA 50, supplied by BASF SE, Germany, which is an aqueous solution containing 50% glutaraldehyde.

Caustic soda is used according to GOST 2263.

Water use distilled or demineralized, or drinking GOST 6709 or GOST 2874.

Introduction in a solution containing glutaric aldehyde, alkyldimethylbenzylammonium chloride, alkali as caustic soda on Iset its bactericidal activity.

All existing tools based on glutaraldehyde and H are weakly acidic or neutral environment. Sometimes, to create this environment, specifically enter the desired reagent, such as citric acid. Acidic environment inhibits the polymerization of glutaraldehyde. High concentration of glutaraldehyde in sanitizer causes large water vapor content of the aldehyde in the air, and this creates limitations due to toxicity of glutaraldehyde. To reduce the toxicity of disinfectants with glutaraldehyde go on the reduction of its content in the tool.

Adding alkali causes alkaline catalysis of aldol condensation of glutaraldehyde with the formation of polyallelic different degrees of polymerization. Polyallelic almost nelituji, and, therefore, toxic fumes aldehyde in the air is practically absent. When the selected ratio of alkali and aldehyde in an aqueous solution (10% glutaraldehyde and 0.1% sodium hydroxide) is formed of a water-soluble polyallelic. When the alkali content is already 0.15% solution appears sediment, probably due to the formation of water-insoluble polyamideacid with a high degree of polymerization. When the content of aldehyde 15% and more clearly smell glutaraldehyde, which increases the inhalation toxicity of funds. Selected soo is wearing alkali and glutaraldehyde is optimal to reduce the inhalation toxicity of funds. This maintains bactericidal activity against gram-positive and gram-negative bacteria, mycobacteria and viruses.

Known lack of effectiveness HOUR for gram-negative bacteria and mycobacteria. The mechanism of resistance of gram-negative bacteria to an HOUR due to the impermeability of the cell wall for molecules HOURS, due to the high content of magnesium ions in the cell wall, for example in its own right. The action of H on Mycobacterium limited growth inhibition, inhibition of development of germinating spores.

Adding alkali to an HOUR enhances bactericidal activity, including gram-negative bacteria, probably due to the binding of magnesium ions, which weakens the connections between molecules of lipopolysaccharides in the cell wall and contributes to the permeability of the HOUR. Apparently, this effect increases sporicidal activity HOUR, which not only leads to growth inhibition of mycobacteria, but also to their death.

Bactericidal activity funds was determined by the value of the minimum bactericidal concentration (MBC) for the test crops in accordance with the "Instructions for determining bactericidal properties of new disinfectants", decl. The USSR Ministry of health 06.05.1968, No. 739-68.

The degree of increase in bactericidal activity was evaluated by the method of Finney D. (D.J. Finney Probit Analysis an tatistical treatment of the Sigmoid Response Curve. London. 1952).

Expected bactericidal activity of the mixture is calculated by the expression:

S(Ci/MBKi)=1/MBqmix.

If experimentally determined MBq mixture more calculated, there is an increase in bactericidal activity, and the numerical value of the ratio of experimental MBq to the computed is called the coefficient of synergy.

The invention is illustrated by the following examples, but are not limited to, where a given ratio of components in the investigated compounds, the visual characteristics of the composition and the value of the minimum bactericidal concentration for the test cultures.

Example 1. Determination of minimum bactericidal concentration of prototype tools Smack-SAC.

The content of active substance in product (wt.%):

Alkyldimethylbenzylammonium chloride - 25; glutaric aldehyde - 25. The total content of the active substance - 50.

By the method of successive dilutions prepare solutions of different concentrations and determine at what minimum concentration of active substances in the solution there is a death (no growth) test culture at the selected exposure. This concentration is considered the minimum bactericidal concentration (MBC). The number of experiments in series 6. The exposure time is 60 minutes

Test culture of Escherichia coli pieces 1257. The maximum dilution, PR is experiencing the death of bacteria, - 3,000 times. The minimum bactericidal concentration (wt.%) - 0,017.

Test culture of Staphylococcus aureaus PCs 209-R. the Maximum dilution at which there is death of bacteria is 2500 times. The minimum bactericidal concentration (wt.%) at 0.020.

The test culture of Bacillus cereus pieces 96. The maximum dilution at which there is destruction of bacteria - 1300 times. The minimum bactericidal concentration (wt.%) - 0,039.

Example 2. Determination of minimum bactericidal concentration of the proposed drug with the contents of alkyldimethylbenzylammonium chloride and glutaraldehyde are above the upper limit. By mixing appropriate amounts of a 50% aqueous solution of glutaric aldehyde (preparation Protectol® GA 50), 50% aqueous solution of alkyldimethylbenzylammonium chloride (preparation Katamin AB), water and sodium peroxide prepare a solution with a content of active substance in product (wt.%):

alkyldimethylbenzylammonium chloride - 15; glutaric aldehyde - 15, sodium hydroxide is 0.1. The total content of the active substance - 30,1.

Get a clear light yellow solution.

By the method of successive dilutions prepare solutions of different concentrations and determine at what minimum concentration of active substances in the solution there is a death (no growth) test culture at the selected exposure. This concentration is considered min the minimum bactericidal concentration (MBC). The number of experiments in series 6. The exposure time is 60 minutes

Test culture of Escherichia coli pieces 1257. The maximum dilution at which there is destruction of bacteria - 1500 times. The minimum bactericidal concentration (wt.%) at 0.020.

Test culture of Staphylococcus aureaus PCs 209-P Maximum dilution at which there is destruction of bacteria - 1500 times. The minimum bactericidal concentration (wt.%) at 0.020.

The test culture of Bacillus cereus pieces 96. The maximum dilution at which there is destruction of bacteria - 1000 times. The minimum bactericidal concentration (wt.%) - 0,030.

Example 3. Determination of minimum bactericidal concentration of the proposed drug with the contents of alkyldimethylbenzylammonium chloride, glutaraldehyde and sodium hydroxide are above the upper limit. By mixing appropriate amounts of a 50% aqueous solution of glutaric aldehyde (preparation Protectol® GA 50), 50% aqueous solution of alkyldimethylbenzylammonium chloride (preparation Katamin AB), water and sodium peroxide prepare a solution with a content of active substance in product (wt.%):

alkyldimethylbenzylammonium chloride - 15; glutaric aldehyde - 15, sodium hydroxide is 0.15. The total content of active substances - to 30.15.

Get the solution slightly brown, which when standing insoluble suspension.

By the method of successive times is aulani prepare solutions of different concentrations and determine at what minimum concentration of active substances in the solution there is a death (no growth) test culture at the selected exposure. This concentration is considered the minimum bactericidal concentration (MBC). The number of experiments in series 6. The exposure time is 60 minutes

Test culture of Escherichia coli pieces 1257. The maximum dilution at which there is death of bacteria - 1500 times. The minimum bactericidal concentration (wt.%) at 0.020.

Test culture of Staphylococcus aureaus PCs 209-R. the Maximum dilution at which there is destruction of bacteria - 1250 times. The minimum bactericidal concentration (wt.%) - 0,024.

The test culture of Bacillus cereus pieces 96. The maximum dilution at which there is destruction of bacteria, is 750 times. The minimum bactericidal concentration (wt.%) - 0,040.

Example 4. Determination of minimum bactericidal concentration of the proposed drug with sodium hydroxide greater than the upper limit. By mixing appropriate amounts of a 50% aqueous solution of glutaric aldehyde (preparation Protectol® GA 50), 50% aqueous solution of alkyldimethylbenzylammonium chloride (preparation Katamin AB), water and sodium peroxide prepare a solution with a content of active substance in product (wt.%):

alkyldimethylbenzylammonium chloride - 10; glutaric aldehyde - 10, sodium hydroxide is 0.15. The total content of the activities of the respective substances 20,15.

Get the solution slightly brown, which when standing insoluble suspension.

By the method of successive dilutions prepare solutions of different concentrations and determine at what minimum concentration of active substances in the solution there is a death (no growth) test culture at the selected exposure. This concentration is considered the minimum bactericidal concentration (MBC). The number of experiments in series 6. The exposure time is 60 minutes

Test culture of Escherichia coli pieces 1257. The maximum dilution at which there is destruction of bacteria, is 800 times. The minimum bactericidal concentration (wt.%) - a 0,025.

Test culture of Staphylococcus aureaus PCs 209-R. the Maximum dilution at which there is destruction of bacteria, is 800 times. The minimum bactericidal concentration (wt.%) - a 0,025.

The test culture of Bacillus cereus pieces 96. The maximum dilution at which there is destruction of bacteria, " 500 times. The minimum bactericidal concentration (wt.%) - 0,040.

Example 5. Determination of minimum bactericidal concentration of the proposed drug with sodium hydroxide at the upper limit. By mixing appropriate amounts of a 50% aqueous solution of glutaric aldehyde (preparation Protectol® GA 50), 50% aqueous solution of alkyldimethylbenzylammonium chloride (preparation Katamin AB), water, and n is the Museum of peroxide prepare a solution with a content of active substance in product (wt.%):

alkyldimethylbenzylammonium chloride - 10; glutaric aldehyde - 10, sodium hydroxide and 0.12. The total content of active substances - 20,12.

Get the solution light yellow color.

By the method of successive dilutions prepare solutions of different concentrations and determine at what minimum concentration of active substances in the solution there is a death (no growth) test culture at the selected exposure. This concentration is considered the minimum bactericidal concentration (MBC). The number of experiments in series 6. The exposure time is 60 minutes

Test culture of Escherichia coli pieces 1257. The maximum dilution at which there is destruction of bacteria - 2000 times. The minimum bactericidal concentration (wt.%) - 0,010.

Test culture of Staphylococcus aureaus PCs 209-R. the Maximum dilution at which there is destruction of bacteria - 2000 times. The minimum bactericidal concentration (wt.%) - 0,010.

The test culture of Bacillus cereus pieces 96. The maximum dilution at which there is destruction of bacteria - 1500 times. The minimum bactericidal concentration (wt.%) - 0,013.

Example 6. Determination of minimum bactericidal concentration of the proposed drug with the content of the active substance at the lower end. By mixing appropriate amounts of a 50% aqueous solution of glutaric aldehyde (preparation Protectol® GA 50), 50% aqueous rest the RA alkyldimethylbenzylammonium chloride (preparation Katamin AB), water and sodium peroxide prepare a solution with a content of active substance in product (wt.%):

alkyldimethylbenzylammonium chloride - 10; glutaric aldehyde - 10, sodium hydroxide to 0.08. The total content of the active substance - 20,08.

Get the solution light yellow color.

By the method of successive dilutions prepare solutions of different concentrations and determine at what minimum concentration of active substances in the solution there is a death (no growth) test culture at the selected exposure. This concentration is considered the minimum bactericidal concentration (MBC). The number of experiments in series 6. The exposure time is 60 minutes

Test culture of Escherichia coli pieces 1257. The maximum dilution at which there is destruction of bacteria - 1900 times. The minimum bactericidal concentration (wt.%) - 0,011.

Test culture of Staphylococcus aureaus PCs 209-R. the Maximum dilution at which there is destruction of bacteria - 1900 times. The minimum bactericidal concentration (wt.%) - 0,011.

The test culture of Bacillus cereus pieces 96. The maximum dilution at which there is death of bacteria - 1250 times. The minimum bactericidal concentration (wt.%) - 0,016.

Example 7. Determination of minimum bactericidal concentration of the proposed drug with the content of the active substance at the upper limit. A suitable mixing the appropriate amounts of a 50% aqueous solution of glutaric aldehyde (preparation Protectol® GA 50), 50% aqueous solution of alkyldimethylbenzylammonium chloride (preparation Katamin AB), water and sodium peroxide prepare a solution with a content of active substance in product (wt.%):

alkyldimethylbenzylammonium chloride - 10,5; glutaric aldehyde - 10,5, sodium hydroxide and 0.12. The total content of the active substance - 21,12.

Get the solution light yellow color.

By the method of successive dilutions prepare solutions of different concentrations and determine at what minimum concentration of active substances in the solution there is a death (no growth) test culture at the selected exposure. This concentration is considered the minimum bactericidal concentration (MBC). The number of experiments in series 6. The exposure time is 60 minutes

Test culture of Escherichia coli pieces 1257. The maximum dilution at which there is destruction of bacteria - 2000 times. The minimum bactericidal concentration (wt.%) - 0,011.

Test culture of Staphylococcus aureaus PCs 209-R. the Maximum dilution at which there is destruction of bacteria - 2000 times. The minimum bactericidal concentration (wt.%) - 0,011.

The test culture of Bacillus cereus pieces 96. The maximum dilution at which there is destruction of bacteria - 1500 times. The minimum bactericidal concentration (wt.%) - 0,014.

Example 8. Determination of minimum bactericidal concentrations the claimed means the content of glutaraldehyde is less than the lower limit. By mixing appropriate amounts of a 50% aqueous solution of glutaric aldehyde (preparation Protectol® GA 50), 50% aqueous solution of alkyldimethylbenzylammonium chloride (preparation Katamin AB), water and sodium peroxide prepare a solution with a content of active substance in product (wt.%):

alkyldimethylbenzylammonium chloride - 10; glutaric aldehyde, 5 - sodium hydroxide is 0.1. The total content of active substances to 15.1.

Get the solution slightly brown, which when standing insoluble suspension.

By the method of successive dilutions prepare solutions of different concentrations and determine at what minimum concentration of active substances in the solution there is a death (no growth) test culture at the selected exposure. This concentration is considered the minimum bactericidal concentration (MBC). The number of experiments in series 6. The exposure time is 60 minutes

Test culture of Escherichia coli pieces 1257. The maximum dilution at which there is destruction of bacteria, is 600 times. The minimum bactericidal concentration (wt.%) - a 0,025.

Test culture of Staphylococcus aureaus PCs 209-R. the Maximum dilution at which there is destruction of bacteria, is 600 times. The minimum bactericidal concentration (wt.%) - a 0,025.

The test culture of Bacillus cereus pieces 96. The maximum dilution at which there is gibel the bacteria, - 400 times. The minimum bactericidal concentration (wt.%) - 0,037.

Example 9. Determination of minimum bactericidal concentration of the proposed drug with the contents of alkyldimethylbenzylammonium chloride is less than the lower limit. By mixing appropriate amounts of a 50% aqueous solution of glutaric aldehyde (preparation Protectol® GA 50), 50% aqueous solution of alkyldimethylbenzylammonium chloride (preparation Katamin AB), water and sodium peroxide prepare a solution with a content of active substance in product (wt.%):

alkyldimethylbenzylammonium chloride - 5; glutaric aldehyde - 10, sodium hydroxide is 0.1. The total content of active substances to 15.1.

Get the solution slightly brown, which when standing insoluble suspension.

By the method of successive dilutions prepare solutions of different concentrations and determine at what minimum concentration of active substances in the solution there is a death (no growth) test culture at the selected exposure. This concentration is considered the minimum bactericidal concentration (MBC). The number of experiments in series 6. The exposure time is 60 minutes

Test culture of Escherichia coli pieces 1257. The maximum dilution at which there is destruction of bacteria, is 600 times. The minimum bactericidal concentration (wt.%) - a 0,025.

Test culture of Staphylococcus aureaus PCs 209-R. M is kimalee dilution, when experiencing the death of bacteria, " 500 times. The minimum bactericidal concentration (wt.%) - 0,030.

The test culture of Bacillus cereus pieces 96. The maximum dilution at which there is destruction of bacteria, is 700 times. The minimum bactericidal concentration (wt.%) at 0.020.

Example 10. Determination of minimum bactericidal concentration of the proposed drug with the content alkyldimethylbenzylammonium chloride and glutaraldehyde is less than the lower limit. By mixing appropriate amounts of a 50% aqueous solution of glutaric aldehyde (preparation Protectol® GA 50), 50% aqueous solution of alkyldimethylbenzylammonium chloride (preparation Katamin AB), water and sodium peroxide prepare a solution with a content of active substance in product (wt.%):

alkyldimethylbenzylammonium chloride - 5; glutaric aldehyde, 5 - sodium hydroxide is 0.1. The total content of active substances to 10.1.

Get the solution slightly brown, which when standing insoluble suspension.

By the method of successive dilutions prepare solutions of different concentrations and determine at what minimum concentration of active substances in the solution there is a death (no growth) test culture at the selected exposure. This concentration is considered the minimum bactericidal concentration (MBC). The number of experiments in series 6. Time is expozitii - 60 minutes

Test culture of Escherichia coli pieces 1257. The maximum dilution at which there is destruction of bacteria - 400 times. The minimum bactericidal concentration (wt.%) - a 0,025.

Test culture of Staphylococcus aureaus PCs 209-R. the Maximum dilution at which there is destruction of bacteria - 400 times. The minimum bactericidal concentration (wt.%) - a 0,025.

The test culture of Bacillus cereus pieces 96. The maximum dilution at which there is destruction of bacteria, is 600 times. The minimum bactericidal concentration (wt.%) - 0,040.

Example 11. Determination of minimum bactericidal concentrations alkyldimethylbenzylammonium chloride. For this use the drug Katamin AB, representing a 50% aqueous solution of alkyldimethylbenzylammonium chloride.

By the method of successive dilutions prepare solutions of different concentrations and determine at what minimum concentration of deistvuyushego substances in solution there is a death (no growth) test culture at the selected exposure. This concentration is considered the minimum bactericidal concentration (MBC). The number of experiments in series 6. The exposure time is 60 minutes

Test culture of Escherichia coli pieces 1257. The maximum dilution at which there is death of bacteria is 2500 times. The minimum bactericidal concentration (wt.%) - 0,02.

Example 12. Definition minimalrebuild concentration of glutaraldehyde. For this use the drug Protectol® GA 50, representing a 50% aqueous solution of glutaraldehyde.

By the method of successive dilutions prepare solutions of different concentrations and determine at what minimum concentration of active substance in the solution is observed deaths (no growth) test culture at the selected exposure. This concentration is considered the minimum bactericidal concentration (MBC). The number of experiments in series 6. The exposure time is 60 minutes

Test culture of Escherichia coli pieces 1257. The maximum dilution at which there is destruction of bacteria, 100 times. The minimum bactericidal concentration (wt.%) 0.5 in.

Example 13. Determination of minimum bactericidal concentration of sodium hydroxide. For this purpose, caustic soda, representing a 40% aqueous sodium hydroxide solution.

By the method of successive dilutions prepare solutions of different concentrations and determine at what minimum concentration of active substance in the solution is observed deaths (no growth) test culture at the selected exposure. This concentration is considered the minimum bactericidal concentration (MBC). The number of experiments in series 6. The exposure time is 60 minutes

Test culture of Escherichia coli pieces 1257. The maximum dilution at which there is destruction of bacteria, is 80 times. Minimalist guest the other bactericidal concentration (wt.%) - 0,5.

As seen from the above examples, the maximum bactericidal activity in which IBC has the smallest value, have the means described in examples 5; 6; 7, where the content of alkyldimethylbenzylammonium chloride is 10.0 to 10.5%, the content of glutaraldehyde is 10.0 to 10.5%, the content of sodium hydroxide is 0,08-0,12%. When the content of active substances outside the stated limits bactericidal activity decreases, as evidenced by the increase in foreign currency.

The expected minimum bactericidal concentration against Escherichia coli, calculated by the method of Finney D., is 0,019%. Experimentally determined MCS is 0.01%. Thus, in the proposed ratio of components microbicides observed a synergistic effect with coefficient value of synergies, equal to 1.9.

The inventive composition microbicides can provide a high level of bactericidal activity against a wide spectrum of infectious diseases at relatively low concentrations of active substances, which reduces its overall toxicity. Get a high bactericidal effect is achieved by an optimal ratio of the active substances in the medium, which affects both the activity funds against pathogens and its phase stability and overall the Yu toxicity.

Antibacterial agent containing a Quaternary ammonium compound, alkyldimethylbenzylammonium chloride, glutaric aldehyde and water, characterized in that it further comprises sodium hydroxide in the following ratio, wt.%:

Alkyldimethylbenzylammonium chloride10,0-10,5
Glutaric aldehyde10,0-10,5
Sodium hydroxide0,08-0,12
WaterRest



 

Same patents:

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to sanitation and can be applied in food, medical, veterinary, processing industry. Invention can be applied for obtaining preparations for disinfection of surfaces in premises, sanitary-technical equipment, items patient care, claimed disinfection preparation can also be applied for disinfection and pre-sterilisation cleaning of products of medical purpose, for disinfection and processing hands of medical personnel. Disinfection preparation includes quaternary ammonium compound, boric acid and represents water solution of quaternary ammonium compound, as such it contains diethyldichloropropenylammonium chloride or diethyldiallylammonium chloride, with the following ratio of initial components, wt %: said quaternary ammonium compound - 1.2 wt %, boric acid - 2.3 wt %, water - the remaining part.

EFFECT: invention ensures increase of bactericidal and fungicidal activity with reduction of concentration of working solutions of preparation, extension of action spectrum, including action on mycobacteria.

4 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine. What is described is a composite material which contains a non-organic substance in the form of a layer or a layer ingredient with the non-organic substance leads to form hydrogen cations in contact with an aqueous medium that induces an antimicrobial effect with the substance being produced of MoO2, MoO3, molybdenum carbide, molybdenum nitride, molybdenum silicide, molybdenum sulphide, molybdenum hexacarbonyl and/or molybdenum acetylacetonate.

EFFECT: antimicrobial effect of the composite material is found through time almost with no limit.

32 cl, 3 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to materials and methods for elimination of live target-cells. Material for elimination of live target-cells contains, at least, one insoluble hydrophobic anionic, cationic or amphoteric charged polymer. Said polymer in contact with water-containing environment: a) is a carrier of strongly acidic or strongly basic functional group; b) has pH value lower than 4.5 or higher than 8.0 and c) possesses proton conductivity and/or electric potential, sufficient for efficient disturbance of pH homeostasis and/or electric balance inside closed volume of said cell. Said charged polymer preserves pH value of medium, surrounding said cells. Said material can be regenerated by regeneration of charged polymer, regeneration of buffer capacity of said material, regeneration of proton conductivity of said material. Manufactured product contains said material.

EFFECT: invention makes it possible to regenerate said purpose.

18 cl, 23 dwg, 9 tbl, 14 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to medicine and may be used in hospitals, polyclinics, resort institutions for high level disinfection and sterilisation. A method for preparing a disinfectant provides mixing of liquid ingredients in the form of two solutions immediately before use. One of the solutions contains, wt %: urea peroxyhydrate - 2-16; corrosion inhibitor Korantin PP - 0.5-2; chelating agent Trilon M Liquid - 0.5-2; sulphuric acid for making the pH value of the solution - 0.5-2; deionised water - the rest. The second solution contains, wt %: ethyl acetate - 20-40; acetic acid - 8-11; potassium bichromate 0.1-0.3; sodium silicate - 0.05-0.7; polyethylene oxide - 0.3-3; acetyl caprolactam - the rest. The relation of the first to second solutions makes 70:1 to 500:1.

EFFECT: group of inventions provide the high disinfecting properties of the product, anti-corrosion effect on steel, non-ferrous metals, chromium-nickel coatings; the agent has no damaging action of the objects to be treated, does not decolour cloths, does not fixes organic impurities, does not damage endoscopes and fibre optics, as well as reduces the solution concentration and exposition time on the treated objects.

3 cl, 1 tbl, 1 ex

Disinfectant // 2466743

FIELD: medicine.

SUBSTANCE: disinfectant containing a chlorinated derivative of isocyanuric acid and a gas-yielding mixture comprises a polymer ingredient specified in a group consisting of polyvinyl alcohol, polyacrylic acid and its copolymers, polyvinylpyrrolidone, water-soluble cellulose esters and their mixture in the following proportions, wt %: chlorinated derivative of isocyanuric acid 20-90, polymer ingredient 0.1-5, gas-yielding mixture - the rest. The gas-yielding mixture represents a mixture of base and acid ingredients. The base ingredient of the disinfectant contains alkaline or alkaline-earth salts of carbonic acid or their mixture. As the acid ingredient, the disinfectant contains organic acids, may contain anticorrosion additives, e.g. sodium benzoate, sodium nitrite, calcium formate, zinc compounds. The disinfectant may contain a builder that is a non-ionic surfactant on the basis of oxyethylated derivatives of alcohols, phenols or organic acids, complexons - salts of ethylenediaminotetraacetic acid, a neutral excipient, e.g. sodium phosphate, sodium sulphate, sodium tartrate, sodium acetate.

EFFECT: invention provides preparing the ready storage-stable disinfection solutions containing active chlorine.

6 cl, 15 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to veterinary and agriculture and represents solution for disinfection, which contains from 0.1% to 10% of 1,8,3,6-diendomethylene-1,3,6,8-tetraasacyclodecane of sodium hydrophosphate. Invention also relates to application of claimed solution.

EFFECT: claimed solution is nontoxic and ecologically safe.

2 cl, 2 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions relates to field of medicine, in particular, to antibacterial compositions. Invention discribes antibacterial composition, device, which contains said composition, method of bacteria destruction, inactivation of viruses, prevention and/or treatment and/or reduction of transmission of bacteria and virus-associated diseases, method of sanitary user's skin processing. Antibacterial composition contains a) from 0.5% to 15% of mixture of surface-active substances, which consist of amino-oxide surface-active substance and, at least, one non-anionic surface-active substance by weight of composition b) from 1% to 15% of mixture of pyroglutamic acid, succinic acid, by weight of composition c) from 15% to 85% of water by weight of composition, with composition being foaming. Composition is applied on place in safe and effective quantity and re-applied if necessary, making it possible for claimed composition to dry and remain on user's skin.

EFFECT: invention provides stable antibacterial composition, which ensures immediate and retained antibacterial activity without irritating skin.

20 cl, 6 ex

FIELD: medicine.

SUBSTANCE: invention refers to veterinary science, namely to agents applied for disinfection. The disinfection composition contains hydrogen peroxide, potassium fluoride, diammonium phosphate, EDTA, sulphonol and a polar solvent (40% aqueous-alcohol mixture) in the following ingredient proportions (wt %): hydrogen peroxide - 4.0-5.0; potassium fluoride -10.0-15.0; diammonium phosphate - 0.3-1.0; EDTA - 0.5-2.0; sulphonol -0.3-1.0; the polar solvent - the rest.

EFFECT: invention provides disinfection of premises contaminated with bacteria, fungi, as well as viruses; it is non-toxic for higher animals and birds that enables to apply it in the presence of animals; it may be stored for a long period of time with no activity loss.

4 cl, 10 tbl, 4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to disinfectants. The disinfectant contains, wt %: isopropanol -60.0, polyhexamethylen biguanide hydrochloride -0.25, alkyldimethylbenzylammonium chloride -0.25, propylene glycol -1.0 and demineralised water to 100. The invention provides intensified antimicrobial activity on gram-positive, including tuberculosis mycobacteria, and gram-negative bacteria, intensified virulicidal activity, including enteral and parenteral hepatitis, HIV-infection, enteroviral infections: poliomyelitis, Coxsackie, ECHO, influenza, including H1N1, H5N1 influenza, acute respiratory viral infection, herpetic, adenoviral infection, intensified fungicidal activity on Candida fungi and dermatophytes.

EFFECT: invention provides skin antiseptic preparation for scrub-up, donor's bend of elbows, skin preparation of surgical and injection areas, and as a disinfectant for small-area and remote surfaces, and besides ensures prolonged 5-hour action.

3 cl, 2 tbl

FIELD: chemistry.

SUBSTANCE: group of inventions relates to medicine, sanitation and hygiene, and can be used as bactericidal, bacteriostatic and antiseptic agents. The first version of the composition (in wt %) contains polyhexamethylene biguanide hydrochloride, alkyldimethylbenzylammonium chloride, taken in ratio of (1.4-1.7):1, and additionally contains detergents which are a mixture of C13/15 ethoxylated fatty acids with 9 and 11 moles of ethylene oxide, taken in ratio of 3.5:5 and nonionised water as a solvent being the balance. The second version of the composition has the following ratio of components, in g: polyhexamethylene biguanide hydrochloride 7-12; alkyldimethylbenzylammonium chloride 5-7; C13/15 ethoxylated fatty acid with 9 moles of ethylene oxide and C13/15 ethoxylated fatty acid with 11 moles of ethylene oxide 10-30; dye 0.00004; nonionised water - up to 100 ml.

EFFECT: group of inventions provides disinfection with a detergent effect.

2 cl, 1 tbl, 3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to sanitation and can be applied in food, medical, veterinary, processing industry. Invention can be applied for obtaining preparations for disinfection of surfaces in premises, sanitary-technical equipment, items patient care, claimed disinfection preparation can also be applied for disinfection and pre-sterilisation cleaning of products of medical purpose, for disinfection and processing hands of medical personnel. Disinfection preparation includes quaternary ammonium compound, boric acid and represents water solution of quaternary ammonium compound, as such it contains diethyldichloropropenylammonium chloride or diethyldiallylammonium chloride, with the following ratio of initial components, wt %: said quaternary ammonium compound - 1.2 wt %, boric acid - 2.3 wt %, water - the remaining part.

EFFECT: invention ensures increase of bactericidal and fungicidal activity with reduction of concentration of working solutions of preparation, extension of action spectrum, including action on mycobacteria.

4 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to sanitation and can be applied in food, medical, veterinary, processing industry. Invention can be applied for obtaining preparations for disinfection of surfaces in premises, sanitary-technical equipment, items patient care, claimed disinfection preparation can also be applied for disinfection and pre-sterilisation cleaning of products of medical purpose, for disinfection and processing hands of medical personnel. Disinfection preparation includes quaternary ammonium compound, boric acid and represents water solution of quaternary ammonium compound, as such it contains diethyldichloropropenylammonium chloride or diethyldiallylammonium chloride, with the following ratio of initial components, wt %: said quaternary ammonium compound - 1.2 wt %, boric acid - 2.3 wt %, water - the remaining part.

EFFECT: invention ensures increase of bactericidal and fungicidal activity with reduction of concentration of working solutions of preparation, extension of action spectrum, including action on mycobacteria.

4 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, particularly to ophthalmology, namely: to antibacterial lenses containing metals, as well as to methods for producing them. The method for producing an antibacterial lens containing a metal salt involves the stages: (a) preparation of a hard lens by a salt precursor, as well as (b) preparation of the lens produced at the stage (a) by a disperse additive specified in a group consisting of polyvinylpyrrolidone, polyvinyl alcohol, glycerol and polyethylene oxide, and a metal-containing agent specified in a group consisting of silver tetrafluoroborate, silver sulphate, zinc acetate, zinc sulphate, copper acetate, copper sulphate, silver nitrate, manganese sulphide, zinc oxide, zinc sulphide, copper sulphide, copper phosphate, silver nitrate, silver sulphate, silver iodate, silver carbonate, silver phosphate, silver sulphide, silver chloride, silver chloride, silver bromide, silver iodide and silver oxide. The other method for producing involves the stages (a) of preparation of a hard lens by a metal-containing agent, and a disperse agent, (b) preparation of the lens prepared at the stage (a) by a salt precursor. The antibacterial lens containing the metal salt is produced by said methods.

EFFECT: group of inventions provides producing the lenses with a decreased degree of opacity.

16 cl, 1 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to medicine and may be used in hospitals, polyclinics, resort institutions for high level disinfection and sterilisation. A method for preparing a disinfectant provides mixing of liquid ingredients in the form of two solutions immediately before use. One of the solutions contains, wt %: urea peroxyhydrate - 2-16; corrosion inhibitor Korantin PP - 0.5-2; chelating agent Trilon M Liquid - 0.5-2; sulphuric acid for making the pH value of the solution - 0.5-2; deionised water - the rest. The second solution contains, wt %: ethyl acetate - 20-40; acetic acid - 8-11; potassium bichromate 0.1-0.3; sodium silicate - 0.05-0.7; polyethylene oxide - 0.3-3; acetyl caprolactam - the rest. The relation of the first to second solutions makes 70:1 to 500:1.

EFFECT: group of inventions provide the high disinfecting properties of the product, anti-corrosion effect on steel, non-ferrous metals, chromium-nickel coatings; the agent has no damaging action of the objects to be treated, does not decolour cloths, does not fixes organic impurities, does not damage endoscopes and fibre optics, as well as reduces the solution concentration and exposition time on the treated objects.

3 cl, 1 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to antibacterial lenses, containing metals and methods of their obtaining. Method of obtaining antibacterial lens, containing metal salt, is characterised by a) stage of processing hardened lens with solution, containing salt precursor and b) processing of lens, obtained at stage a) with solution, containing metal-containing agent, where molar ratio of said metal-containing agent in its solution constitutes from 0.6 to 10.0.

EFFECT: invention ensures obtaining antibacterial lens with low content of opacity/Ag, which makes possible its long application with transparency, sufficient for user to be able to see through the lens clearly.

10 cl, 1 tbl, 1 dwg, 4 ex

Disinfectant // 2466743

FIELD: medicine.

SUBSTANCE: disinfectant containing a chlorinated derivative of isocyanuric acid and a gas-yielding mixture comprises a polymer ingredient specified in a group consisting of polyvinyl alcohol, polyacrylic acid and its copolymers, polyvinylpyrrolidone, water-soluble cellulose esters and their mixture in the following proportions, wt %: chlorinated derivative of isocyanuric acid 20-90, polymer ingredient 0.1-5, gas-yielding mixture - the rest. The gas-yielding mixture represents a mixture of base and acid ingredients. The base ingredient of the disinfectant contains alkaline or alkaline-earth salts of carbonic acid or their mixture. As the acid ingredient, the disinfectant contains organic acids, may contain anticorrosion additives, e.g. sodium benzoate, sodium nitrite, calcium formate, zinc compounds. The disinfectant may contain a builder that is a non-ionic surfactant on the basis of oxyethylated derivatives of alcohols, phenols or organic acids, complexons - salts of ethylenediaminotetraacetic acid, a neutral excipient, e.g. sodium phosphate, sodium sulphate, sodium tartrate, sodium acetate.

EFFECT: invention provides preparing the ready storage-stable disinfection solutions containing active chlorine.

6 cl, 15 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to field of medicine, in particular, to ophthalmology. Group of inventions relate to antibacterial lenses, which contain metals, and methods of there production. Antibacterial lens which contains metal salt, obtained by method (versions), which includes stages: (a) processing hardened lens by solution, which contains metal-containing preparation and efficient quantity of acid substance, where pH of claimed solution constitutes from 2 to 5; and (b) processing of lens from (a) stage with solution, containing, basically containing or consisting of salt precursor and efficient quantity of acid substance, where pH of said solution constitutes from 2 to 5.

EFFECT: group of inventions ensures obtaining contact lenses, which contain antibacterial medications of constant composition.

19 cl, 2 dwg, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to veterinary science, namely to agents applied for disinfection. The disinfection composition contains hydrogen peroxide, potassium fluoride, diammonium phosphate, EDTA, sulphonol and a polar solvent (40% aqueous-alcohol mixture) in the following ingredient proportions (wt %): hydrogen peroxide - 4.0-5.0; potassium fluoride -10.0-15.0; diammonium phosphate - 0.3-1.0; EDTA - 0.5-2.0; sulphonol -0.3-1.0; the polar solvent - the rest.

EFFECT: invention provides disinfection of premises contaminated with bacteria, fungi, as well as viruses; it is non-toxic for higher animals and birds that enables to apply it in the presence of animals; it may be stored for a long period of time with no activity loss.

4 cl, 10 tbl, 4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to disinfectants. The disinfectant contains, wt %: isopropanol -60.0, polyhexamethylen biguanide hydrochloride -0.25, alkyldimethylbenzylammonium chloride -0.25, propylene glycol -1.0 and demineralised water to 100. The invention provides intensified antimicrobial activity on gram-positive, including tuberculosis mycobacteria, and gram-negative bacteria, intensified virulicidal activity, including enteral and parenteral hepatitis, HIV-infection, enteroviral infections: poliomyelitis, Coxsackie, ECHO, influenza, including H1N1, H5N1 influenza, acute respiratory viral infection, herpetic, adenoviral infection, intensified fungicidal activity on Candida fungi and dermatophytes.

EFFECT: invention provides skin antiseptic preparation for scrub-up, donor's bend of elbows, skin preparation of surgical and injection areas, and as a disinfectant for small-area and remote surfaces, and besides ensures prolonged 5-hour action.

3 cl, 2 tbl

FIELD: chemistry.

SUBSTANCE: group of inventions relates to medicine, sanitation and hygiene, and can be used as bactericidal, bacteriostatic and antiseptic agents. The first version of the composition (in wt %) contains polyhexamethylene biguanide hydrochloride, alkyldimethylbenzylammonium chloride, taken in ratio of (1.4-1.7):1, and additionally contains detergents which are a mixture of C13/15 ethoxylated fatty acids with 9 and 11 moles of ethylene oxide, taken in ratio of 3.5:5 and nonionised water as a solvent being the balance. The second version of the composition has the following ratio of components, in g: polyhexamethylene biguanide hydrochloride 7-12; alkyldimethylbenzylammonium chloride 5-7; C13/15 ethoxylated fatty acid with 9 moles of ethylene oxide and C13/15 ethoxylated fatty acid with 11 moles of ethylene oxide 10-30; dye 0.00004; nonionised water - up to 100 ml.

EFFECT: group of inventions provides disinfection with a detergent effect.

2 cl, 1 tbl, 3 ex

FIELD: medicine, virology, pharmacy.

SUBSTANCE: invention relates to using derivatives of dithiocarbamate of the formula: R1R2NCS2H and oxidized forms of these compounds, in particular, their dimmers and their pharmaceutically compatible salts for preparing an agent used in treatment or prophylaxis of infection caused by RNA-containing viruses that damage respiratory tract and inducing disease. Also, invention relates to a disinfecting agent containing dithiocarbamate compound and a method for disinfection of surfaces, media and cell cultures.

EFFECT: valuable medicinal properties of compounds.

19 cl, 14 dwg, 14 ex

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