Disinfecting preparation

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to sanitation and can be applied in food, medical, veterinary, processing industry. Invention can be applied for obtaining preparations for disinfection of surfaces in premises, sanitary-technical equipment, items patient care, claimed disinfection preparation can also be applied for disinfection and pre-sterilisation cleaning of products of medical purpose, for disinfection and processing hands of medical personnel. Disinfection preparation includes quaternary ammonium compound, boric acid and represents water solution of quaternary ammonium compound, as such it contains diethyldichloropropenylammonium chloride or diethyldiallylammonium chloride, with the following ratio of initial components, wt %: said quaternary ammonium compound - 1.2 wt %, boric acid - 2.3 wt %, water - the remaining part.

EFFECT: invention ensures increase of bactericidal and fungicidal activity with reduction of concentration of working solutions of preparation, extension of action spectrum, including action on mycobacteria.

4 tbl, 1 ex

 

The invention relates to sanitation and can be used in food, medical, veterinary, food processing industry, first of all, to obtain preparations for disinfection of surfaces in premises, sanitary-technical equipment, patient-care items, also suggested disinfectant study group can be used for disinfection and pre-sterilization of medical devices for disinfection and treatment of the hands of medical personnel.

Known disinfectant, a mixture of alkyldimethylbenzylammonium chloride 10.0 to 12.0 wt.%, the alkaline agent in an amount of 5.0-10.0 wt.%, alcohol isopropyl 8.0 to 12.0 wt.% in the aquatic environment. [RF patent 2146151, IPC A61L 2/16, 2000].

Creating an alkaline environment helps to enhance the bactericidal effect of alkyldimethylbenzylammonium chloride against several bacteria and viruses. The disadvantages of the drug should be attributed to the relatively low effectiveness against atypical and typical mycobacteria, including Mycobacterium tuberculosis, as well as quite a long time exposure during processing.

Known industrially produced disinfectants, such as Katanin AB, Alumina, Sterilium etc. ["Disinfectant. Part 1. Disinfectants, Directory. Issue 2, M, 998, p.72, 112, 153], obtained by mixing the active ingredient with water to form a water solution of a certain concentration. Katamin AB is a 49-51%aqueous solution of alkyldimethylbenzylammonium chloride, is designed to disinfect the infectious diseases of bacterial etiology, except tuberculosis. Sterilium is a composition of 2-propanol (45%), 1-propanol (30%), Quaternary ammonium compounds (0.2%) and water (rest) and is designed for hygienic treatment of hands of medical personnel. Alumina is a composition of catamine AB (5%), glyoxal (5%) and water and is designed for disinfection of bacterial infections, including tuberculosis, and viral etiology, including hepatitis and HIV.

Get remedies would be ineffective or insufficiently effective against a number of bacteria that have a high concentration of working solutions, a long exposure time, not to be stable when stored.

Known biocidal product containing the peroxide compound (perhydrol or hydroponic), Quaternary ammonium base (H) and hydrochloric salt of high molecular weight tertiary amine (SU, 1587725, 1995).

The disadvantage of this structure should recognize the presence of biocidal environment salts of amines, and hydrogen peroxide, resulting in increased toxic the t of the proposed composition, that excludes its use in medicine, veterinary medicine and food industry.

Known disinfectant with the following quantitative content of ingredients, wt.%: the urea clathrate didecylammonium bromide - 20, ethanol - 20, distilled water 60 (EN 2095086, A61L 2/18, 1997).

This structure is used primarily for disinfection of surfaces in premises, sanitary-technical equipment, patient-care items and does not have sufficient antimicrobial activity when used for air, steam and cold sterilization of medical products.

But this tool has a relatively low bactericidal and fungicidal activity.

Known antiseptic for the prevention of HIV/AIDS, a mixture of boron or organic acids or glaskolben of 0.2 to 6.0 wt.%, cationic surfactant of 0.01-0.5 wt.%, low molecular weight glycol is 1.0-10.0 wt.%, tween 80 or tween 20 or tween 60 0.1 to 5.0 wt.% in the environment constituency. [RF patent 2007186, IPC A61L 2/16, 1994]. As the cationic surfactant used alkyldimethylbenzylammonium chloride, the acid is an organic low-molecular and high-molecular acid.

The above means exerts bactericidal activity only in an acidic environment, which does not effectively use the AMB known compositions for surface treatment prone to corrosion degradation. In addition, although some funds have a wide range of actions, work with them unsafe for human health as an effective bactericidal effect is achieved with high concentrations of working solutions, which requires compliance with certain precautions.

The closest to the technical essence and the achieved result and the use of the original components is a disinfectant, containing as active substance Quaternary ammonium compound and the excipient, as the acid component (boric acid, or acidic salts of phosphoric acid, or acidic salts of sulfuric acid, and others, in the following ratio, wt.%: H:auxiliary substance, equal 85-95:5-15) [patent No. 2277425 IPC A61K 9/20, A61K 31/14, A61L 2/16, 2005].

The disadvantage of this tool is relatively low bactericidal and fungicidal activity, high concentrations of H and boric acid.

The objective of the invention is the expansion of the range of antiseptic and disinfectants, increased activity of the disinfectant and expanding the range of its action, including antimycobacterial, while reducing the consumption of reagents by reducing the concentration of working solutions.

the left task is achieved by what disinfectant, comprising a Quaternary ammonium compound, boric acid according to the invention is an aqueous solution of Quaternary ammonium compound, which contains diethylaminopropylamine chloride with the following ratio of initial components, wt.%:

- diethylaminopropylamine to 1.2 wt.%,

- boric acid - 2,3% wt.,

- water - the rest.

In the practical use of the claimed invention can be obtained from the following technological and social results:

- obtain relatively cheap and more effective antiseptic and disinfectant;

a significant simplification of technology for disinfectants;

- obtaining non-corrosive disinfectant, which will serve as a reliable protection for expensive medical equipment from different Korroziya factors and harmful environmental influences;

- getting a new qualitative composition that combines two active component that allows you to have a reciprocal influence on each other and show better results.

The above technical results of the invention are achieved by the fact that at the temperature of 15÷20°C diethylaminopropylamine chloride is mixed with b the nuclear biological chemical (NBC acid in the aquatic environment. The resulting solution was thoroughly stirred for 10-15 minutes.

The specified Quaternary ammonium compound obtained by alkylation of secondary amines with chlorolepidotus part of organochlorine waste of allylchloride by the reaction:

(C2H5)2NH+2ClCH2CH=CHCl→[(C2H5)2N(CH2CH=CHCl)2]+Cl+HCl

To 222 g of clarified waste of allylchloride composition: 30-50% 1,3-dichloropropene, 30-60% 1,2-dichloropropane, 3-5% 1,2,3-trichlorpropane, was added 103 g diethylamine (the molar ratio of 1,3-dichloropropene:diethylamin is 1.0:1,4). The mixture is stirred at 50°C for 1 hour, after which through the separating funnel into the reactor enter NaOH in the form of a 30%aqueous solution until neutral environment.

Then to the resulting reaction mass through a separating funnel, add another 222 g of clarified waste of allylchloride of the same composition, as in the first stage, bring the temperature of the reaction mixture to 70°C. and stirred for 5 hours. After cooling the mixture to room temperature, it is placed in a separating funnel. The organic layer containing di - and trichlorpropane, is recycled for their separation by simple distillation.

The reaction course was monitored by the number of unreacted secondary amine, which was determined titre is the use of a 0.1 N solution of hydrochloric acid. Determination of the mass concentration of the chloride ions by titration with 0.05 M solution of nitrate of mercury (II). The content of H in the product was determined by titration of 0.004 N solution of pyridinium chloride [Dissertation A.A. Islamutdinov on the topic "Synthesis of Quaternary ammonium compounds on the basis of waste production allylchloride and their practical application", 2006].

Table 1 shows the physico-chemical characteristics of the disinfectant.

Table 1
NameIndex
1. Appearancecolorless liquid
2. Solubility at 30°Cit is soluble in water, soluble in alcohol, diethyl ether, glycerin
3. Insolublecetarehhloristam carbon
4. Relative density, g/ml1,1-1,6

The essence of the invention is proved by the examples.

Example 1.

The disinfectant is obtained by simple mixing of the starting components at room the Oh temperature.

In a container with a stirrer load consistently 0.5 g diethylaminopropylamine chloride and 25 g of boric acid, pour the water before the formation of 1 l of solution. Stirring is continued for 10÷15 minutes. Get a pale yellow syrupy liquid with a densityg/cm3.

Examples of the preparation of compositions with other ratios of reagents is prepared analogously to example 1, are presented in table 2.

Table 2
ExamplesName of the component, g/l
Diethylaminopropylamine chlorideBoric acid
2.0,7525
3.125
4.1,525

Components disinfectants, % wt.

1. Diethylaminopropylamine chloride1,2
2. Boric acid2,3/td>
3. Water96,5

Performed laboratory tests on the effectiveness of salamou composition as a disinfectant during the disinfection of drinking water in the bacteriological laboratory of the Sterlitamak state epidemiology center RB Protocol (laboratory studies No. 1302 from February 25 2010 Testing laboratory centre. The branch of Federal state institution "CT and epidemiology in the Republic of Belarus, Sterlitamak).

The tests were carried out as follows: in a sterile deklarirovannoe tap water contributed a suspension of microorganisms: Escherichia coli, Klebsiella, Salmonella-typhimurium and typhoid, Shigella, V. cholerae, coliphages, and then added disinfectant. The initial concentration of microorganisms in the investigated volume of water was 1×106SOME(PFU)/ml exposure Time is 20 minutes.

After the experience of neutralization of the investigated water samples have been sowing on solid nutrient medium to determine the number of viable microorganisms. Served as control samples, in which synthesized the tool was not introduced.

The results are shown in table 3.

The presented results suggest the death under the influence of means of pathogenic bacteria (Ho the cluster of Vibrio cholerae, Shigella, Salmonella) and sanitary-indicative microorganisms (E. coli, Klebsiella, coliphages). Thus, the agent is effective in disinfecting drinking water, mode of application: the exposure time is 20 minutes.

When studying disinfecting activity used surfaces (linoleum, ceramic floor tile, tile, wood, painted with oil paint) size 10×10 cm, which caused the resulting desiredto 0.5 ml After drying their surfaces were treated twice with a solution of the proposed drug at a rate of 5 ml per 100 cm2. After incubation of 30, 60, 90 minutes at room temperature, rinse the surface was determined residual infection. These studies are presented in table 4.

Table 3
The research results on the effectiveness of the disinfectant
The concentration of dietitian
propenyl
ammonium chloride/
boric acid, g/l
The number of observations
data
The destruction of microorganisms (control)
intestinal p the shell Klebsiella
La
Salmonella typhoid feverSalmonella, entireityShigella ZoneStaphylococcus aureuscoliphagesProteusShigella Boyd
0,5/256151515202015151515
0,75/25652,045,548,356,956,059,154,453,0of 54.8
1/25667,560,263,876,276,174,369,268,2 69,5
1,5/25697,496,198,510010010099,8100100

Table 4
SurfaceComposition of the disinfectant examplesThe concentration of water R-RA, % ROThe efficiency of disinfection, % at the time of contact
306090
Linoleumfor example 10,599,799,899,9
1,099,999,9100,0
a well-known tool1,099,7 99,9100,0
Tilefor example 10,599,799,899,9
1,099,999,999,9
a well-known tool1,099,799,9100,0
Tilefor example 20,599,799,899,9
1,099,999,999,9
a well-known tool1,099,899,9100,0
Tilein example 40,599,799,9100,0
1,099,999,9100,0
a well-known tool1,099,799,9100,0
Treefor example 30,599,799,899,9
1,099,999,9100,0
a well-known tool1,099,999,9100,0

Thus, the inventive method of obtaining a disinfectant, helps to increase its bactericidal activity against a wide spectrum of pathogens with relatively low concentrations of the active substance. Get sverhsummarny the effect of the simultaneous presence in the composition of diethylaminopropylamine chloride and boric acid is achieved by the fact that in the present method creates a particular environment at a particular ratio of the compound is, what affects activity of the composition against pathogens.

Based on the examples it can be argued that the inventive method allows to obtain the disinfectant characteristics (high specificity to the Mycobacterium, Staphylococcus and E. coli, high activity, low toxicity, no corrosive, irritating action on the skin with prolonged use, does not cause degradation of the treated surface), superior counterparts in bactericidal action.

Disinfectant, comprising a Quaternary ammonium compound, boric acid, characterized in that it is an aqueous solution of Quaternary ammonium compound, which contains diethylaminopropylamine chloride with the following ratio of initial components, wt.%:

the specified Quaternary ammonium compound1,2
boric acid2,3
waterrest



 

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5 cl, 12 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, particularly to ophthalmology, namely: to antibacterial lenses containing metals, as well as to methods for producing them. The method for producing an antibacterial lens containing a metal salt involves the stages: (a) preparation of a hard lens by a salt precursor, as well as (b) preparation of the lens produced at the stage (a) by a disperse additive specified in a group consisting of polyvinylpyrrolidone, polyvinyl alcohol, glycerol and polyethylene oxide, and a metal-containing agent specified in a group consisting of silver tetrafluoroborate, silver sulphate, zinc acetate, zinc sulphate, copper acetate, copper sulphate, silver nitrate, manganese sulphide, zinc oxide, zinc sulphide, copper sulphide, copper phosphate, silver nitrate, silver sulphate, silver iodate, silver carbonate, silver phosphate, silver sulphide, silver chloride, silver chloride, silver bromide, silver iodide and silver oxide. The other method for producing involves the stages (a) of preparation of a hard lens by a metal-containing agent, and a disperse agent, (b) preparation of the lens prepared at the stage (a) by a salt precursor. The antibacterial lens containing the metal salt is produced by said methods.

EFFECT: group of inventions provides producing the lenses with a decreased degree of opacity.

16 cl, 1 tbl

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