Method for prevention of severe complications accompanying surgical management of massive and submassive blood loss with continuous haemorrhages
SUBSTANCE: invention refers to medicine, namely resuscitation and may be used for prevention of severe complications in surgical management of massive and submassive blood loss with continuous haemorrhages. That is ensured by the intraoperative intravenous drop-by-drop introduction of Perftoran 2-4 ml/kg following mechanical arrest of the continuous haemorrhages. With underlying restorable blood volume, higher body oxygenation with eliminated nitrogen oxide inhalation. Rheamberyn is introduced in an average therapeutic dose at the end of the operation and on the first three postoperative days.
EFFECT: invention provides higher effectiveness of infusion-transfusion management, improved clinical course of the operative and postoperative period, reduced percentage of complications and mortality.
The present invention relates to the field of medicine, resuscitation, and can be used to increase the effectiveness of perioperative infusion-transfusion providing surgical treatment of massive blood loss with ongoing bleeding.
Despite the achievement of surgery, anesthesiology, intensive care Transfusiology, efficient provision of surgical treatment of acute and subacute hemorrhage with ongoing bleeding remains one of the most actual problems of modern medicine.
There are various ways to treat bleeding. So, there is a method of restoring circulating blood through the introduction of a medicinal product. As drug use lectin, which is injected intravenously and intramuscularly (see RF Patent 2066190, 1996, AV 35/55).
The known method transfusion of perftoran during surgery, the infusion was started after the introduction of the patient to the anesthesia and was carried out with a speed of 50-60 drops per minute (see Biryukov DL, Petrova M.V. possibility of optimization of the transport of oxygen by the application of emulsion perftoran in patients with surgical treatment of lung cancer. // Performancesee compounds in biology and medicine: scientific transactions., 2001. - C.116-119).
The disadvantage of this method is the gain does not remain blencogo bleeding and the appearance of increased bleeding tissue, especially in cases of weakening of the hemostatic system, for example due to excessive dilution of the blood with blood substitutes. When the transfusion of perftoran during surgery for General anesthesia using nitrous oxide is necessary to reduce the oxygen content in the inhaled gas mixture of 30% and below.
Closest to the claimed is a method of treatment of bleeding by introducing reamberine patients with gastroduodenal ulcer bleeding. In the course of conservative treatment patients underwent intensive therapy according to the severity of the condition and along with the standard therapy was performed infusion of Reamberine 1.5% in 400 ml 2 times a day during the whole period of stay in the intensive care unit. (Morgunov S. Application of reamberine intensive therapy of gastroduodenal bleeding. // Metod.rekom. - Izhevsk: IHM, 2006 - 10 seconds). However, increased tissue demands for oxygen (reduced shipping) leads to the breakdown of the energy circuits in the tissues and, ultimately, to complications such as weakness of the cardiac activity. Another disadvantage is the danger of using reamberine for correction of hypoxia in the conditions of decreased oxygen delivery to the tissues under such pathological conditions as pulmonary edema, respiratory distress syndrome of adults voznikayushie is as complications of massive blood loss.
The technical result of the proposed method is to increase the efficiency of infusion-transfusion support, improve current surgical and postoperative period, a lower rate of complications and mortality.
New to the achievement of the technical result is that during the operation to impose perftoran 2-4 ml/kg intravenous drip after mechanical stop ongoing bleeding on the background of the restoring circulating blood volume, high oxygenation of the body with the exception of inhalation of nitrous oxide. New is also that Reamberin pour in srednestatisticheskiy dose at the end of surgery and in the first three days after surgery.
The introduction of perftoran before infusion reamberine improves the delivery of oxygen to tissues that activates the metabolic action of reamberine and prevents the buildup of oxygen deficiency in the tissues caused by the activation of metabolic processes. The effects from the use of perftoran fully manifested when pouring the drug in small quantities. Achieved prior to the introduction of perftoran activation of the metabolic actions of reamberine allows you to restore the metabolism in the cells and prevent the development of fatal complications. While doing due to the fact that the period m is xymalos efficiency of perftoran is observed within 1 hour after infusion. The joint introduction of perftoran and reamberine will vzaimopoleznoe positive effects of drugs: antihypoxic, anti-oxidant, rheology, microcirculation, diuretic, detoxifying, repeatedly accelerating oxigenada and deoxyribose processes of the hemoglobin of red blood cells depending on the partial pressure of oxygen in the environment, activating the enzymatic processes of the Krebs cycle, improving respiration and detoxifying function of the liver, restoring the energy potential of the cells. The authors found that the inclusion of infusion of perftoran and reamberine in the program of infusion-transfusion ensure emergency operations during bleeding with massive blood loss and the carrying out of these infusions on the basis of the established principles improves the course of operative and post-operative periods and reduces the amount and intensity of needed treatment.
Comparative analysis of the prototype shows that the inventive method is characterized by the fact that during the operation to impose perftoran 2-4 ml/kg intravenous drip after mechanical stop ongoing bleeding on the background of the restoring circulating blood volume, high oxygenation of the body with the exception of inhalation of nitrous nitrogen, and Reamberin pour in srednestatisticheskiy dose at the end of operation is in the first three days after surgery, that meets the criterion of "novelty."
A new set of features improves the efficiency of infusion-transfusion support, improve current surgical and postoperative period, a lower rate of complications and mortality, reduction in the duration of hospital stay after surgery, reduce the dose of the drugs used, celebrated early postoperative activation of patients that meets the criterion of "industrial applicability".
The method is as follows.
After reaching the surgical hemostasis conduct replenishment of circulating blood volume, further correction of anemia, acute metabolic changes in the blood, the stabilization of the oncotic pressure of plasma, which provides the necessary oxygen transport to the tissues and transcapillary exchange. The main means of infusion-transfusion therapy are isotonic solution of sodium chloride and colloidal solutions (gelofusine, 6% solutions gidroksietilirovannogo starch - infocol BSE, reportan, voluven, dextrans) in the ratio 3:1. Part of transfused environments include inkjet-drip transfusion 2-3 doses melted fresh frozen plasma. To replenish the lost red blood cells are used donor erythrocytapheresis environment in the quantity required is ω for maintaining a chosen level of hemodilution (hematocrit in the range of 25-30%, hemoglobin 80-90 g/l). In case of hemodynamic inefficiency obamamobile therapy connect cardiotonic and vazopressornye intravenous therapy (dopamin, dopamine, adrenaline and others) in doses that provide the necessary stabilization of hemodynamics. In severe injuries using a single administration of large doses of glucocorticoids.
After creating giperwolemicescoy hemodilution, after a stop ongoing bleeding mechanically, with careful surgical hemostasis during surgery impose perftoran in a dose of 2-4 ml/kg intravenous infusion at a rate of 30 drops per minute after first running the tests for tolerance (reactogenicity) drug. Transfusion of perftoran during surgery and in the first day after the transfusion the patient provide high oxygenation, as is the ability of perftoran to carry oxygen is in direct linear dependence on the partial pressure of oxygen in the environment. It reaches enrichment in the inhaled oxygen to 70-85%for respiratory support by means of artificial ventilation of the lungs or through the nasal catheters. Transfusion of perftoran during surgery for General anesthesia do not use nitrous oxide, as its application is necessary to reduce retained the s of oxygen in the inhaled gas mixture of 30% and below. Maintaining adequate anesthesia intravenous reach fractional administration of fentanyl (4-5 µg/kg/h), calypsol (2 mg/kg/h), ardoin (0,02-0,04 mg/kg/h), diazepam (5-10 mg before induction of anaesthesia and at the final stage of the operation). Not later than one hour after infusion of perftoran poured Reamberin in the medium therapeutic dose of 400 ml with a speed of 4.0 to 4.5 ml/min on the background keep hypervolemia, stable hemodynamics and high oxygenation of the body. After surgery, daily for 3 days, poured in 400 ml of reamberine on the background of high oxygenation of the body.
The proposed method is illustrated by the following clinical examples.
Example 1. Patient I., 36 years old, weight 72 kg, entered the x/o Bachurski CRH 10.01.2008, 02.15 with a diagnosis of a Knife penetrating wound of the abdomen with damage to internal organs. Intra-abdominal bleeding, hemorrhagic shock II Art. From the anamnesis it is known that knife wound received about 4 hours ago in the village Harlan (60 km from CRH), examined by a nurse, after first aid car SMP delivered in CDH, during transport was carried out small-volume infusion therapy (R-R ringer - 400, sodium chloride 0,9% - 400). Heredity without features, comorbidities, no. At admission the patient's condition is extremely serious. Lethargic, drowsy. Leather is s integument pale, cold. The symptom of "white spots" more than 3 seconds In the epigastric region two wounds linear shape with a length up to 3 cm, from wounds scarce hemorrhagic discharge. In the lungs vesicular breathing, weak in the lower divisions, the number of 20 breaths per minute heart sounds muffled, rhythmic. Blood pressure is 80/40 mm Hg, pulse 120 beats per minute, on peripheral arteries is not defined. Abdomen, painful on palpation, the symptoms of peritoneal irritation positive. Produced catheterization upper Vena cava to the right, CVP - negative, continues infusion therapy. When catheterization of the bladder received a small amount of urine is straw-yellow color.
The General analysis of blood: Hb - 52 g/l, Ht - 17%, erythrocytes - 1,95·1012/l, leucocytes - 12,6·109/l, platelets - 112·109/l, total protein - to 54.4 g/l, AST - 63 u/l, ALT - 22 e/l In the study of hemostasis - prothrombin index 81%, fibrinogen - 2.5 g/l, coagulation time by Burker - 5 min 30 s, the rate of bleeding by Duque - 2 min 05 C.
"Shock index" - 1.5 (deficit BCC - 40%), which corresponds to the condition is extremely severe, the estimated blood volume by the method of F. Moore was 5040 ml (deficit BCC - 60%).
The patient urgently taken to the operating room. Under the General multicomponent anesthesia and artificial ventilation air produced verkhnesadinsky l is paroemia, revision of the abdominal cavity, suturing wounds of the right lobe of the liver and small intestine, sanitation and drainage of the abdominal cavity. During the operation of the abdomen removed 2.5 liters of blood, contaminated small bowel contents, clots up to 0.2 liters
Hemodynamics during surgery unstable, there was a decrease in a/D to 20/0, heart rate was not determined, was conducted inotropic support with dopamine at a dose of 5 ml/kg/min
After surgical hemostasis (suturing wounds of the liver) infusion-transfusion therapy was performed in the regime of moderate giperwolemicescoy hemodilution (sodium chloride 0.9% reportan 6%), against this background, transferred perftoran in the amount of 2.8 ml/kg, which helped stabilize the hemodynamics after 15 min from the start of the infusion (a/D - 125/80 mm Hg). At the final stage of the operation transferred to 400 ml of reamberine. Only during the operation transferred: erythrocyte mass - 550 ml, AW - 940 ml, reportan 6% - 1250 ml sodium chloride 0.9 per cent 1200 ml ringer's solution - 1000 ml, Global - 400 ml, Reamberin 1,5% - 400 ml, perftoran - 200 ml
Postoperative diagnosis: combined Penetrating stab wound of the abdomen, the wound in the right lobe of the liver, the loops of the small intestine. The ongoing massive intra-abdominal bleeding. Hemorrhagic shock III degree.
After surgery the patient within 8 hours was on prolongedopen the th AV. In the early postoperative period in a serious condition, stable hemodynamics And/D - 130/80 mm Hg, pulse 96 / min, good content.
Complete blood count: Hb - 72 g/l, Ht - 23%, erythrocytes - 2,15·1012/l, leucocytes - 10,6·109/l, platelets - 154·109/l, LII (Calf-Khalifa) - 2,1; GPI - 1,8 Wed; bilirubin - 10.6 µmol/l; AST - 48,4 u/l; ALT - 19.2 e/l; total protein decreased to 46.6 g/l; cholesterol - 3.1 mmol/l; urea - 4.9 mmol/l; creatinine - 59 µmol/l urine Output adequate to 70 ml/h without stimulation.
During the following days, the state with the positive dynamics, complications were noted, were conducted infusion-correcting therapy (in which shimmered Reamberin), symptomatic, antibacterial.
On the fourth day after surgery the patient is improving transferred to the Department of surgery. Discharged 14 days after surgery in satisfactory condition.
Example 2. Patient P., 42, weight 68 kg, was admitted to the surgical Department Bachurski CRH 15.02.2010, 13.15 clinic with gastrointestinal bleeding (vomiting coffee grounds, black stools, dizziness, weakness, morning, twice mentioned the collapse). Ulcer history is missing, considers himself ill with 12.02.2010, comorbidities not.
When you receive a state of heavy, lethargic, severe pallor with acrocyanosis, dizziness, weakness. Skin is arrowy pale, cold, wet. In the lungs vesicular breathing, number of breaths - 24 in minutes heart sounds deaf, pulse 120 per minute, rhythmic, weak filling, HELL 60/40 mm Hg blood: Hb - 46 g/l, Ht - 11.9%, erythrocytes is 1.48·1012/l, leucocytes - 19,2·109/l, platelets - 225·109/l, total protein of 45.4 g/l, AST - 43 u/l, ALT - 25 u/L. In the study of hemostasis - prothrombin index 95%, fibrinogen - 1,9 g/l, coagulation time by Burker - 5 min 00 sec, the rate of bleeding by Duque - 2 min 15 sec. "Shock index" - 2 (CBV deficit - more than 40%), which corresponds to the condition is extremely severe, the estimated blood volume by the method of F. Moore was 4420 ml (deficit BCC - 70%). On the background of respiratory support oxygen with FiO2- 0.3 to (via nasal catheter) conducted preoperative preparation (reportan 6% - 500 ml ringer's solution and 600 ml sodium chloride 0.9 per cent 600 ml). The patient was urgently operated. Operations: chronic ulcer of the anterior wall of the gastric body with the transition to the small curvature in the infiltrate, with penetration into the right lobe of the liver; blood in the lumen of the stomach, small and large intestines. After separation of the infiltrate in the gastric wall formed defect with a diameter of 2 cm with profuse bleeding vessel from the wall. Performed resection of the stomach. Hemodynamics during surgery unstable, until the pulse disappears and a/D, intr PNA support - dopamine at a dose of 8 µg/kg/min After ligation of the left gastric artery conducted infusion of perftoran - 200 ml (2,9 ml/kg)over 20 minutes from the start of infusion occurred stabilization of the a/D level 120/90 mm Hg, pulse rate was 108 beats per minute. At the final stage of the operation transferred to 400 ml of reamberine. During the operation transferred: red blood cells - 500 ml, AW - 840 ml, infocal 6% - 500 ml ringer's solution and 600 ml sodium chloride 0.9 per cent 1000 ml, perftoran - 200 ml, Reamberin - 400 ml.
After surgery the patient within 2 hours were on prolonged mechanical ventilation. In the early postoperative period in a serious condition, stable hemodynamics And/D - 130/80 mm Hg, pulse - 94 min, good filling. Complete blood count: Hb - 79 g/l, Ht - 25%, erythrocytes - 2,87·1012/l, leucocytes - 14,6·109/l, platelets - 121·109/l, LII (Calf-Khalifa) - 2,8; GPI - 2,1 u.ed; bilirubin - 7.4 µmol/l; AST - 36,4 u/l; ALT - 24,1 u/l; total protein decreased to 48.6 g/l; cholesterol - 2.1 mmol/l; urea - 5.6 mmol/l; creatinine - 48 µmol/l urine Output adequate to 70 ml/h without stimulation.
During the following days, the state with the positive dynamics was conducted infusion-correcting therapy, which included daily Reamberin in a dose of 400 ml, symptomatic, antibacterial therapy.
On the fourth day after surgery the patient is improving transferred to the Department of surgery. yesan for 12 hours after surgery in satisfactory condition.
The way to prevent serious complications in the surgical treatment of massive and submassive blood loss from continuing bleeding by introducing reamberine, characterized in that during the operation to impose perftoran 2-4 ml/kg intravenous drip after mechanical stop ongoing bleeding on the background of the restoring circulating blood volume, high oxygenation of the body with the exception of inhalation of nitrous oxide, and Reamberin injected into srednestatisticheskiy dose at the end of surgery and in the first three days after surgery.
SUBSTANCE: invention refers to medicine. What is prescribed is taking a beverage made of soluble granulated magnolia-vine extract. The beverage 250 ml is taken before a dip for 20 days three times a day.
EFFECT: use of the declared method enables unfavourable changes of water and electrolyte metabolism in divers.
SUBSTANCE: invention refers to medicine. What is prescribed is a beverage made of soluble granulated magnolia-vine extract. The beverage 250 ml is taken before a dip (compression in a vacuum chamber) for 20 days three times a day.
EFFECT: method is high-effective for prevention of compressed-air disease in divers.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine and pharmacology and represents the use of water-soluble hybrid macromolecular compounds: O-(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionyl)-(1→6)-α-D-glucan, polyethylene glycol bis-3-(3,5-di-tert-butyl-4-hydroxyphenyl)-propionate as agents improving survival rate in wound shock.
EFFECT: invention provides the extended range of products applied in therapy for wound shock.
4 ex, 1 tbl
SUBSTANCE: invention relates to medicine, namely to combuistology, resuscitation and intensive care, narcology and can be used in patients in state of drug intoxication with use of desomorphine. For this purpose determined are patient's body weight, degree of drug intoxication expression and physiological needs of organism during a day. After that volume of deintoxication-infusion therapy is calculated by formula: V= Cdix(CsxBW)+ PN, where V is volume of infusion therapy, in ml; Cdi - coefficient of drug intoxication expression: 1.0 in case of changed reactivity to drug substance; 1.5 - in case of presence of psychic dependence (obsessive attraction); 2.0 - in case of presence of physical dependence (compulsive attraction); 2.5 - in case of abstinence syndrome; Cs is coefficient of somatic aggravation with use of desomorphine, equal 0.2; BW is patient's body weight in grams; PN is physical needs of organism during a day, in ml.
EFFECT: method makes it possible to ensure adequate infusion therapy in patients with different degree of expression of drug intoxication with desomorphine.
SUBSTANCE: invention relates to medicine, and is intended for stimulation of intestinal peristalsis in early post-operation period in patients with cancer of esophagus and cardial part of stomach. Plasma-substituting solution "Mafusol" is introduced enterally. "Mafusol" is additionally introduced parenterally in quantity 800-1200 ml per day.
EFFECT: method makes it possible to restore intestinal peristalsis on first-second day after operation.
FIELD: medicine, pharmaceutics.
SUBSTANCE: declared invention refers to chemical-pharmaceutical industry, and concerns a plasma-substitute compound with the rheological and hemodynamic properties on the basis of a block copolymer of ethylene oxide and propylene oxide, and hydroxyethylstarch, and using it in medicine and cosmetology.
EFFECT: preparing the plasma-substitute compound with the improved rheological and hemodynamic properties of mixed two active ingredients: the surfactant proxanol - the block copolymer of ethylene oxide and propylene oxide of molecular weight 1 to 20 kDa and the hemodynamic agent hydroxyethylstarch of molecular weight 40 to 200 kDa in the ratio of 1/1 to 10/10 respectively with an acceptable electrolyte solution.
10 cl, 8 ex
SUBSTANCE: invention refers to medicine, namely to purulent surgery, and may be used in treating patients with folliculitis and furuncles. For this purpose, at first forceps are used to remove an inflammation cone cover. A syringe is used to aspirate the purulent-necrotic mass. Before bandaging, the inflammation region is treated with the preparations Polcortolon or Oxycort.
EFFECT: method provides a cosmetic effect ensured by prevented formation of a hard hypertrophic scar due to elimination of punctures and incisions.
SUBSTANCE: invention refers to medicine, particularly anesthesiology and intensive care, and can be used for treating multiple-organ-failure syndrome in the patients who underwent cardiac surgeries. That is ensured by evaluation of the risk factors of developing multiple-organ-failure syndrome. Their absence enables standard intensive care. If within 12 hours after the cardiac surgery there are observed acute reduced cardiac output and reduced ejection fraction with the combined introduction of adrenaline and dobutamine appeared to be ineffective, differentiated interventional therapy of multiple-organ-failure syndrome is performed with using a calcium-sensitising agent taken among the cardiac support. The presence of haemodynamic criteria of acute lung injury combined with systemic inflammation response, prolonged renal replacement therapy in continuous veno-venous hemofiltration is performed. It is combined with a simultaneous complex of respiratory kinesiological rehabilitation with differentiated selection of a respiratory support method. On the forth day of artificial pulmonary ventilation, puncture-dilatation tracheostomy is performed.
EFFECT: method provides predicting a risk of developing multiple-organ-failure syndrome in a given category of patients at the early stage following the surgery.
SUBSTANCE: invention relates to medicine, namely to obstetrics and gynecology, and can be used in treatment of rhesus sensitisation and prevention of hemolytic disease of fetus. For this purpose titre of rhesus-antibodies is determined and if titre of rhesus-antibodies is higher than 1:32 and high titre of subclasses IgG1 and IgG3 carried out is course of therapeutic plasmapheresis, which includes from 3 to 5 sessions with removal of 10-30% of circulating plasma volume. Plasma compensation is performed with hydroxyethylated starch with ratio to removed plasma 1.2-1.5:1. Interval between sessions of therapeutic plasmapheresis constitutes 1-2 days. After finishing course of therapeutic plasmapheresis, intravenous immunoglobulin therapy is performed in dose 5.0 g with interval between immunoglobulin transfusions 1-2 days. If titre of rhesus-antibodies higher than 1:32 and high titre of subclasses IgG1 and IgG3 remains, courses of therapeutic plasmapheresis and immunoglobulin therapy are repeated throughout pregnancy.
EFFECT: method ensures prevention of development of severe forms of hemolytic disease of fetus and makes it possible to prolong pregnancy to terms of obtaining viable fetus due to stable reduction of titre of rhesus-antibodies and titre of IgG1 and IgG3 subclasses, as well as minimisation of probability of rebound-effect development as a result of combined application of therapeutic plasmapheresis and immunoglobulin therapy.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, and concerns a method for making a hemodialysis solution used in extracorporal blood purification for treating patients with acute and chronic renal insufficiency. The hemodialysis solution contains the following components, mmol/l: Sodium chloride NaCl 137.3-140.3; Calcium chloride CaCl2·2H2O 1.2-1.75; Magnesium chloride MgCl2·6H2O 0.5-1.0; Potassium chloride KCl 0.3-4.0; Glucose, g/l 1.0-5.0; Hydrochloric acid 0.1-2.9; Amber acid C4H6O4 0.1-2.9; Sodium bicarbonate 32.0.
EFFECT: invention aims at producing a physiologic composition of an acid component with no acetic acid added, providing minimum complications in the form of acidosis, and haemodynamic stability in patients of a risk group and a cardiac intensive profile.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry and concerns an ergogenic formulation possessing adaptogenic, hepatoprotective and immunomodulatory action, and may be used in hepatic diseases, in decreases in immunity and increase in performance efficiency and tolerance. The composition contains burnut extract, zinc aspartate, magnesium aspartate, vitamin B6, water in certain proportions of the ingredients.
EFFECT: composition possess higher pharmacological activity and bioavailability.
SUBSTANCE: invention relates to veterinary medicine. Method of obtaining preparation for stimulation of non-specific resistance and metabolism in animals includes mixing succinic acid with tissue preparation ADS F-2 (antiseptic Dorogov's stimulator fraction-2), sodium nucleinate and wastes of biological industry, obtained after cultivation of quail fibroblasts on primary culture medium, which includes synthetic medium MEM (minimal Eagle medium), synthetic medium 199 and cattle blood serum in the following component ratio, g/l: succinic acid - 6-7 ADS F-2 - 30-35, sodium nucleinate - 20-25, wastes of biological industry, obtained after cultivation of quail fibroblasts - to 1 l, succinic acid and sodium nucleinate are preliminarily subjected to ultraviolet irradiation.
EFFECT: invention ensures obtaining preparation, which produces expressed stimulating action on metabolism, possesses antioxidant properties and increases natural resistance of animal organism.
9 tbl, 4 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to method of manufacturing compositions, containing potassium bicarbonate and sodium picosulfate, which includes stage of application by spraying sodium picosulfate solution on potassium bicarbonate and drying of said salts with formation of granules, containing sodium picosulfate layer on potassium bicarbonate core. Invention also relates to composition, suitable for obtaining composition, which possesses laxative action, which contains granules, including sodium picosulfate layer, applied on potassium bicarbonate core. Invention also relates to composition, possessing laxative action, and to method of its obtaining, which contains granules of homogeneous mixture of citric acid, magnesium oxide, potassium bicarbonate and sodium picosulfate, and possibly sodium saccharin and/or orange flavouring agent, with granules containing sodium picosulfate, applied on potassium bicarbonate core.
EFFECT: invention is aimed at obtaining composition, which can be used for emptying of bowels before X-ray examination, endoscopy or surgery, which is homogeneous and possesses improved characteristics.
34 cl, 2 dwg, 3 ex
SUBSTANCE: invention refers to an agent for treating drug and alcohol dependences which contains an organic colour. The organic colour is specified in a group containing gentian violet, malachite green oxalate, Sudan Black B, Rhodamine 6G or a mixture of said colours and methylene green. The invention also refers to a method of treating drug or alcohol dependence which consists in the introduction of said agent within the dose range of 0.15 mg to 5 g.
EFFECT: invention provides the non-toxic and causing no side effects agent for treating drug addiction and alcohol abuse in pharmaceutically acceptable doses with reduced length of treatment and increased clinical effectiveness.
13 cl, 13 ex
SUBSTANCE: invention refers to medicine, and concerns prevention of acute compressed air disease. For this purpose, water immersion is preceded by the single drop-by-drop introduction of the preparation remaxol 100 ml for 60 minutes.
EFFECT: method enables considerably reducing a number of cases of compression air disease in divers due to intensifying tissue respiration, providing higher cell membrane resistance to lipid peroxidation and restoring enzymatic activity of antioxidant protection.
SUBSTANCE: invention relates to medicine, namely to oncology, and can be used for treatment of cerebrovascular diseases and asthenic syndrome. For this purpose mixture of medications, consisting of cytoflavin 2.0 ml and novocaine 0.5% - 5.0 ml, is introduced in lymphotropic way by interstitial injection into posterior zone of neck suboccipitally.
EFFECT: invention makes it possible to achieve reduction of dose of used medications, as well as minimise development of undesirable reactions of introduced medications.
SUBSTANCE: maleic acid derivatives having general formula
have metallo-β-lactamase inhibiting activities. It is possible to recover anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of general formula (I) with β-lactam antibiotics. The metallo-β-lactamase inhibitor is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 denotes C2-6-alkyl; C3-7-cycloalkyl, where said cycle can be substituted with a hydroxyl group or can be condensed with an aryl; hydroxymethyl; - C1-3-alkylene phenyl, where said phenyl group can be substituted with a hydroxyl group, C1-6-alkyl group, hydroxymethyl group, a -COOM group, where M denotes a hydrogen atom or a pharmaceutically acceptable cation, a -CO-NR22R23 group, where R22 and R23, which can be identical or different, denote a hydrogen atom or C1-6-alkyl, wherein the alkyl can additionally be substituted with an aminocarbonyl, or R22 and R23, together with a nitrogen atom with which they are bonded, can form a five- or six-member saturated heterocyclic ring containing 1-2 oxygen or nitrogen atoms, and the heterocycle can be substituted with a hydroxyl group or a C1-6-alkanoyloxy group, a -O-R24 group, where R24 denotes C1-6-alkyl, wherein the alkyl is optionally substituted with an aminocarbonyl, an amine group, a guanidine group or a five- or six-member saturated heterocycle, having 1-2 nitrogen atoms, -COOM, where M denotes a hydrogen atom, C1-6-alkyl or a pharmaceutically acceptable cation, or a five- or six-member unsaturated heterocycle, having 1-2 nitrogen atoms; - C0-1 alkylene heterocycle, where said heterocycle is a five- or six-member saturated or unsaturated heterocycle containing one nitrogen or oxygen atom and can be substituted with a hydroxyl group; - O-C1-6-alkyl; or - S-C1-6-alkyl, R2 denotes C1-6-alkyl, C3-7-cycloalkyl, where said cycle can be substituted with a hydroxyl group or can be condensed with an aryl; or - C1-3-alkylene phenyl, each M1 independently denotes a hydrogen atom, a pharmaceutically acceptable cation.
EFFECT: new metallo-β-lactamase inhibitor acts as a medicament for inhibiting inactivation of β-lactam antibiotics and recovering anti-bacterial activities.
18 cl, 3 tbl, 98 ex
SUBSTANCE: invention refers to medicine, namely ophthalmology and physiotherapy, and may be used for treating vascular and dystrophic retinal and visual nerve diseases. That is ensured by the intravenous drop-by-drop infusion of the 2/3 amount of the medical solution made of cytoflavin 10 ml and 0.9% sodium chloride 200 ml. It is followed by 15-minite transverse halvanisation in the Potok-1 apparatus at current force making 0.5 mA. For this purpose 2 oval anode electrodes through a pad impregnated in distilled water are placed on skin of closed eyelids of both eyes and connected by a Y-wire with the anode of the apparatus. The third cathode electrode is placed transversally in relation to the two first anode electrodes on the area of upper cervical spines S2-S4 and connected with the cathode of the apparatus. The therapeutic course makes 10 daily procedures.
EFFECT: method provides high clinical effectiveness ensured by high functional effectiveness of cytoflavin electric accumulation in eye tissue with improving visual acuity by 0,15-0,3, prolonged action of the ensured therapeutic effect up to 5-6 months, eliminated risk of damaging an external eyeball capsule.
1 tbl, 2 ex
SUBSTANCE: invention refers to medicine, namely occupational pathology, and may be used for correction of cognitive dysfunction and vegetative-sensory polyneuropathy in the patients with vibration disease. That is ensured by prescribing health resort treatment and drug-induced therapy. The drug-induced therapy involves the intravenous drop-by-drop introduction of cytoflavin 20 ml per 5% glucose 200 ml daily for 10 days.
EFFECT: invention provides improving higher cortical functions in the given category of the patients due to the developed enhanced regimen of the preparation dosage.
1 dwg, 1 tbl, 2 ex
SUBSTANCE: invention relates to field of dentistry and presents sparkling composition for oral cavity care, which contains arginine bicarbonate, orthophosphoric acid and soluble carbonate salt.
EFFECT: invention ensures stable composition and, due to the fact, that arginine spools the composition, ensures reduction of demineralisation of teeth under the influence of acid, and, without performing negative impact on sparkling composition.
21 cl, 12 ex
SUBSTANCE: invention refers to fine stable emulsions of perfluoroorganic compounds (PFOC) which may be used as a base for preparing blood substitutes with gas transport function, as well as radiopaque contrast agents and mediums for organ preservation. The emulsion contains PFOC in the amount of 8÷80.0 wt %, an emulsifying and stabilising additive in the amount of 0.25÷8.0 wt % and a physiologically acceptable solution - the rest. The emulsifying and stabilising additive of the emulsion is presented by a non-ionic surfactant presenting mixed block copolymers of ethylene oxide and/or propylene oxide and/or polyalkylene glycol esters of tocopherol with polyglycidyl esters of fluorinated alcohols in relation 2:1 to 0.5:1, or the anionic surfactant presenting a monoester salt of dicarboxylic acid with aliphatic and/or pxyalkylated aliphatic and/or perfluorinated alcohols, or mixed said non-ionic and anionic surfactants in relation 39:1 to 1:39.
EFFECT: emulsion under the invention is aggregation- and sedimentation-stable; average particle size is no more than 200 nm; it is stored for a long period of time at room and high temperature with no substantial change in emulsion particle size.
11 cl, 24 tbl, 23 ex