Pyrimidine compounds, compositions and methods of use

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new pyrimidine derivatives and their pharmaceutically acceptable salts possessing the properties of a mTOR kinase inhibitor. In formula (I): A represents a 6-8-member mono- or bicyclic heterocyclic ring containing 1 to 2 heteroatoms optionally specified in N and O as apexes of the ring and having 0-2 double bonds; and wherein the ring A is additionally substituted by 0 to 2 substitutes RA specified in a group consisting of -ORa, -Rc and -(CH2)1-4-ORa wherein Ra is optionally specified in hydrogen and C1-6alkyl; Rc represents C1-6alkyl; G is specified in a group consisting of -C(O)-, -OC(O)-, -NHC(O)- and -S(O)0-2-; B is specified in a group consisting of phenylene and 5-6-member heteroarylene consisting 1-2 nitrogen heteroatom as apexes of the ring, and substituted by 0 to 1 substitutes RB specified in F, Cl, Br, I and Rp; wherein Rp represents C1-6 alkyl; D is specified in a group consisting of -NR3C(O)NR4R5, -NR4R5, C(O)NR4R5, -NR3C(=N-CN)NR4R5, -NR3C(O)R4, -NR3C(O)OR4 and -NR3S(O)2R4, and wherein the group D and a substitute placed on an adjoining atom in the ring B, optionally combined to form a 5-6-member heterocyclic or heteroaryl ring containing 1 to 3 heteroatoms specified in N, O and S, as apexes of the ring and substituted by the substitute 0-1 RD. The R1-R5 radical values are presented in the patent claim.

EFFECT: invention also refers to a pharmaceutical composition containing said compounds, and to the use of the compounds for preparing a drug for treating a malignant tumour mediated by mTOR kinase activity.

33 cl, 13 dwg, 4 tbl, 498 ex

 

The text descriptions are given in facsimile form.

1. The compound of the formula I

or its pharmaceutically acceptable salt, where in formula I,
But a 6-8-membered mono - or bicyclic heterocyclic ring containing 1 to 2 heteroatoms independently selected from N and O, the vertices of the ring, and has 0-2 double bonds; and where the ring And optionally substituted from 0 to 2 substituents RAselected from the group consisting of-ORa, -Rcand -(CH2)1-4-ORawhere Raindependently selected from hydrogen and C1-6of alkyl; Rcrepresents a C1-6alkyl;
R1and R2combined with the atoms to which they are attached, with the formation of a 5-8-membered saturated mono - or bicyclic heterocyclic ring containing-N(W)- as one of the peaks of the ring, where W is represented by formula i

where E is selected from the group comprised the soup from hydrogen, phenyl,5-10heteroaryl containing 1-3 heteroatoms selected from N, O and S, With3-6cycloalkyl,3-6geterotsiklicheskie containing 1-3 heteroatoms selected from N, O and S, With1-6of alkyl, C1-6halogenoalkane, -O-C1-6the alkyl and-S(O)2-C1-6of alkyl; and where E is independently substituted by from 0 to 2 substituents REselected from the group consisting of F, Cl, Br, I, -NRdRe, -ORd, -C(O)ORd, -C(O)NRdRe, -C(O)Rd, -S(O)2Rd, -Rf, -NO2,=O, and-CN; where Rdand Reeach, independently, selected from hydrogen and C1-6of alkyl, and optionally Rdand Rewhen attached to the same nitrogen atom, merged to form a 3-6-membered heterocyclic ring containing a heteroatom of nitrogen; Rfselected from C1-6of alkyl, C1-6halogenoalkane,3-7cycloalkyl and phenyl; and where any two Deputy located on adjacent atoms, or located on the same atom, optionally combined with the formation of 6-membered heterocyclic ring containing 1-2 of nitrogen heteroatom;
F is selected from the group consisting of C1-6alkylene and C2-6Alcanena; where F is independently substituted by from 0 to 3 substituents RFselected from the group consisting of F, Cl, Br, -ORg, -C(O)NRgRhand=O; Rgand Rheach independent is isimo, selected from hydrogen and C1-6of alkyl;
G is selected from the group consisting of-C(O)-, -OC(O)-, -NHC(O) -, and-S(O)0-2-;
subscripts m and p each, independently, is an integer from 0 to 1;
where 5-8-membered heterocyclic ring formed by combining R1and R2additionally optionally substituted by from 0 to 2 substituents RRselected from the group consisting of-C(O)ORj, -Rm, -(CH2)1-4-CN, -(CH2)1-4ORj, -(CH2)1-4NRjRk, -(CH2)1-4-CO2RjWith2-4albaniles-CO2Rjand=O, where Rjselected from hydrogen and C1-6of alkyl, and Rjand Rkwhen attached to the same nitrogen atom, are optionally combined with education 3-6-membered heterocyclic ring containing 1-2 heteroatoms selected from N, O and S; and Rmselected from C1-6the alkyl and C2-6alkenyl, and where, when R1and R2combined with the formation of monocyclic 5-8-membered heterocyclic ring, then any two substituent attached to the same or to adjacent atoms of the monocyclic 5-8-membered heterocyclic ring, optionally combined with education 5-6-membered cycloalkyl ring, a 5-6-membered geteroseksualbnogo ring containing 1-2 heteroatoms selected from N and O, or a 5-membered, heteroa the ilen ring, containing 1 heteroatom selected from N, O and S and is substituted by from 0 to 1 substituent RR;
In selected from the group consisting of phenylene and 5-6-membered of heteroaryl containing 1-2 heteroatoms of nitrogen in the vertices of the rings, and substituted from 0 to 1 substituents RBselected from F, Cl, Br, I, and Rp; where Rprepresents a C1-6alkyl;
D is selected from the group consisting of-NR3C(O)NR4R5, -NR4R5C(O)NR4R5, -NR3C(=N-CN)NR4R5, -NR3C(O)R4, -NR3C(O)OR4and-NR3S(O)2R4where R3represents hydrogen; R4and R5each, independently, selected from the group consisting of hydrogen, C1-6of alkyl, C1-6halogenoalkane,3-5cycloalkyl,3-9geterotsiklicheskie containing 1-2 heteroatoms selected from N and O, the phenyl and C5-6 gheteroaryl containing 1-3 heteroatom selected from N and O, and R4and R5when attached to the same nitrogen atom, are optionally combined with the formation of 5-membered heteroaryl ring containing 1 to 2 nitrogen heteroatoms in the vertices of the ring; and R3, R4and R5additionally substituted by 0 to 3 substituents RDindependently selected from the group consisting of F, Cl, Br, I, -CN, -NRqRr, -ORq,=O and RS;
where Rqand R rselected from hydrogen, C1-6of alkyl and benzyl; and RSin each case, independently selected from C1-6the alkyl and C3cycloalkyl;
and where the group D and the Deputy located on an adjacent atom in the ring, optionally merged to form a 5-6 membered heterocyclic or heteroaryl ring containing 1 to 3 heteroatoms selected from N, O and S, the vertices of the rings, and substituted Deputy 0-1 RD.

2. The compound according to claim 1, where a is selected from the group consisting of phenylene, perederina, pyrimidine, pyridinoline and pyrazinamide, and substituted from 0 to 1 substituent RBselected from F, Cl, Br, I, and Rpwhere Rprepresents a C1-6alkyl;
D is selected from the group consisting of-NR3C(O)NR4R5, -NR4R5C(O)NR4R5, -NR3C(=N-CN)NR4R5, -NR3C(O)R4, -NR3C(O)OR4and-NR3S(O)2R4where R3represents hydrogen; R4and R5each, independently, selected from the group consisting of hydrogen, C1-6of alkyl, C1-6halogenoalkane,3-5cycloalkyl,3-7geterotsiklicheskie containing 1-2 heteroatoms selected from N and O, the phenyl and C5-6heteroaryl containing 1-2 heteroatoms selected from N and O, and R4and R5when attached to the same nitrogen atom, long is Ino merged to form optionally substituted 5-membered heteroaryl ring, containing 1 to 2 heteroatoms selected from N, the vertices of the ring; and R3, R4and R5additionally substituted by 0 to 3 substituents RDindependently selected from the group consisting of F, Cl, Br, I, -CN, -NRqRr,=O and RS; where Rqand Rrselected from hydrogen, C1-4of alkyl and benzyl; and RSin each case, independently selected from C1-4the alkyl and C3cycloalkyl; and where the group D and the Deputy located on an adjacent atom in the ring, optionally combined with education optionally substituted 5-6-membered heterocyclic or heteroaryl ring containing 1 to 3 heteroatoms selected from N, the vertices of the rings.

3. The compound according to claim 2 in which the ring a is a ring selected from the group consisting of morpholine-4-yl, 3-methyl-morpholine-4-yl, 3-ethyl-morpholine-4-yl, 3-ISO-propyl-morpholine-4-yl, 3,3-dimethyl-morpholine-4-yl, 3,4-dihydro-2H-Piran-4-yl, 3,6-dihydro-2H-Piran-4-yl, tetrahydro-2H-Piran-4-yl, 1,4-oxazepan-4-yl, piperidine-1-yl, 2-oxa-5-azabicyclo[2,2,1]heptane-5-yl, 3-oxa-8-azabicyclo[3,2,1]Octan-8-yl, 4-methoxy-piperidine-1-yl and optionally substituted from 1 to 2 substituents RAselected from the group consisting of-ORaand Rcwhere Raselected from hydrogen and C1-6of alkyl, and Rcrepresents a C1-6alkyl; and before the hat is optionally substituted group selected from optionally substituted phenylene, pyrimidinamine and pirivena.

4. The compound according to claim 1, where In represents an optionally substituted ring selected from the group consisting of 1,4-phenylene, 2,5-pirivena and 2,4-pirivena.

5. The compound according to claim 1, where the compound of formula I selected from the group consisting of:

where RRselected from the group consisting of-Rm, -(CH2)1-4-CN, -(CH2)1-4-CO2Rj, -(CH2)1-4ORj, -(CH2)1-4NRjRkWith2-4albaniles-CO2Rjand=O; and RBselected from the group consisting of F, Cl, Br, I, and Rpwhere Rprepresents a C1-6alkyl.

6. The compound according to claim 1, where the compound of formula I selected from the group consisting of

where RRis a-Rm; and RBselected from the group consisting of F, Cl, Br, I, and Rpwhere Rprepresents a C1-6alkyl.

7. The compound according to claim 5 or 6, where D is selected from the group consisting of-NR3C(O)NR4R5, -NR4R5C(O)NR4R5, -NR3C(=N-CN)NR4R5, -NR3C(O)R4, -NR3C(O)OR4and-NR3S(O)R4.

8. The compound according to claim 5 or 6, where D is an optionally substituted group selected from-NR3C(O)NR4R5and-NR4R 5where R3represents hydrogen; R4and R5each independently represent an optionally substituted group selected from the group consisting of hydrogen, C1-6of alkyl, C1-6halogenoalkane,3-5cycloalkyl,3-7geterotsiklicheskie containing 1-2 heteroatoms selected from N and O, the phenyl and C5-6heteroaryl containing 1-3 heteroatom selected from N and O, and R4and R5when attached to the same nitrogen atom, are optionally combined with education optionally substituted 5-membered heteroaryl ring containing 1-2 heteroatoms of nitrogen.

9. The connection of claim 8, where D represents - NR4R5where R4represents hydrogen or C1-3alkyl, and R5is an optionally substituted group selected from optionally substituted phenyl,5-6heteroaryl containing 1-2 heteroatoms selected from N and O, and C3-7geterotsiklicheskikh containing 1-2 heteroatoms selected from N and O.

10. The connection according to claim 9, where D represents-NR4R5where R4represents hydrogen or C1-3alkyl, and R5represents an optionally substituted C3-7geterotsiklicheskikh selected from the group consisting of:

where the hydrogen atom attached to the one or more ring nitrogen atoms or carbon in C 3-7heterocyclicamines ring optionally substituted by substituent RDselected from the group consisting of F, Cl, Br, I, -NRqRr, -ORqand RS.

11. The connection of claim 10, where R5selected from the group consisting of:

12. The connection of claim 8, where D represents-NR4R5where R4and R5when attached to the same nitrogen atom, are optionally combined with the formation of 5-membered heteroaryl ring containing 1 to 2 nitrogen heteroatoms as vertices ring selected from the group consisting of pyrrolyl, pyrazolyl and imidazolyl.

13. The connection of claim 8, where D represents NR3C(O)NR4R5where R3represents hydrogen; R4and R5each, independently, represent an optionally substituted group selected from the group consisting of hydrogen, C1-6of alkyl, C1-6halogenoalkane,3-5cycloalkyl,3-7geterotsiklicheskie, 5-6-membered heteroaryl and optionally substituted phenyl.

14. The connection indicated in paragraph 13, where one of R4and R5represents hydrogen.

15. The connection 14, where R3and R4each represent hydrogen and R5is an optionally substituted group selected from C1-6the alkyl and C1-6halogenic the La.

16. The connection indicated in paragraph 15, where R5selected from the group consisting of

17. Connection P16, where R5represents ethyl.

18. The connection indicated in paragraph 13, where R3and R4each represent hydrogen or C1-4alkyl, and R5is an optionally substituted group selected from the group consisting of optionally substituted isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, pyrazole-3-yl, pyrazole-4-yl, pyrazole-5-yl, 1,2,3-oxadiazol-4-yl, 1,2,3-oxadiazol-5-yl, 1,3,4-oxadiazol-2-yl, 1,3,4-oxadiazol-5-yl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 5-pyridyl, cyclobutyl, cyclopentyl, 2-oxetanyl, 3-oxetanyl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl and phenyl.

19. Connection p, where R5independently substituted by from 0 to 3 substituents selected from F, Cl, Br, I, -CN, -NRqRrand-ORq.

20. The connection according to claim 19, where R5selected from the group consisting of

21. The compound according to claims 1, 5 or 6, where in formula I, E is an optionally substituted group selected from the group consisting of phenyl, C5-10heteroaryl containing from 1 to 3 heteroatoms, independently selected from N, O and S, With3-6geterotsiklicheskie and C3-6cycloalkyl; F represents an optional samisen the th group, selected from the group consisting of C1-4alkylene,2-4Alcanena, G is selected from the group consisting of-C(O)-, -OC(O)-, -NHC(O) -, and-S(O)2-; and the subscripts m and p each, independently, is an integer from 0 to 1.

22. Connection item 21, where in formula I, E is an optionally substituted group selected from the group consisting of optionally substituted pyridyl, pyrimidinyl, chinoline, pyrazinyl, pyridazinyl, phenyl, pyrrolyl, pyrazolyl, oxazolyl, thiazolyl, piperidinyl, pyrrolidinyl, morpholinyl, furanyl, triazinyl, thiadiazolyl, imidazolyl, cyclobutyl, cyclopropyl, cyclopentyl, cyclohexyl, pyridinyl, tetrahydrofuranyl, tetrahydropyranyl, DIOXOLANYL, tetrahydropyrimidine and tetrahydropyranyl; F represents an optionally substituted group selected from the group consisting of C1-4alkylene,2-4Alcanena,1-4heteroalkyl, G is selected from the group consisting of-C(O)-, -OC(O)-, -NHC(O) -, and-S(O)2-; and the subscripts m and p are each, independently, is an integer from 0 to 1.

23. Connection p.22, where E is selected from the group consisting of

where the hydrogen atom attached to one or more ring nitrogen atoms or carbon in C6-10aryl, C5-10heteroaryl, C3-8heterocyclicamines and C3-8qi is loucile ring optionally substituted by substituent R E.

24. Connection item 21, where the subscripts m and p are each equal to 1.

25. Connection item 21, where the subscript m is 0, and the subscript p equal to 1.

26. The compound according to claim 1 or 5, where W is selected from the group consisting of



27. The compound according to claims 1, 5 or 6, where D is selected from the group consisting of

28. Connection, including:
1-ethyl-3-(4-(4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)aniline
tert-butyl 2-(2-aminopyrimidine-5-yl)-4-(3,4-dihydro-2H-Piran-4-yl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate
4-(7-benzyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)aniline tert-butyl 2-(4-AMINOPHENYL)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
4-(2-(1H-indazol-5-yl)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-4-yl)morpholine
tert-butyl 2-(4-(methylamino)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
1-(4-(7-acetyl-4-(1,4-oxazepan-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
4-(2-(4-(1H-pyrazole-1-yl)phenyl)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-4-yl)morpholine
(S)-1-ethyl-3-(4-(7-(2-HYDR shall xypropyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(4-(3,6-dihydro-2H-Piran-4-yl)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(7-(pyrimidine-2-yl)-4-(tetrahydro-2H-Piran-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1,1-dimethyl-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
N-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)pyrimidine-2-amine
1-ethyl-3-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(Z)-2-cyano-1-methyl-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)guanidine
1-(4-(7-benzyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-isopropyl-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(4-(1,4-oxazepan-4-yl)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(7-(2-aminopyrimidine-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(4-morpholino-7-(oxazol-4-carbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-morpholino-7-(oxazol-5-carbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
tert-butyl 2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(E)-2-cyano-1-ethyl-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)guanidine
1-(4-(7-benzoyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-yl)phenyl)-3-atilmotin
4-(7-benzoyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl ethylcarbamate
ethyl 4-(7-benzoyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylcarbamate
1-ethyl-3-(4-(7-isonicotinoyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-morpholino-7-nicotinoyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-morpholino-7-pikolinos-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(5-ethylpyrimidine-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(1-methyl-1H-pyrazole-5-carbonyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(4-methoxypyridine-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-morpholino-7-(thiazol-2-carbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(morpholine-4-carbonyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
tert-butyl 2-(4-(3-ethyl-1-methylurea)phenyl)-4-morpholino-5,6-dihydropyri is to[3,4-d]pyrimidine-7(8H)-carboxylate
1-cyclopentyl-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
benzyl 2-(4-(3-ethylurea)phenyl)-4-morpholino-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate
benzyl 2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-ethyl-3-(4-(7-(2-hydroxy-2-phenylacetyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-1-ethyl-3-(4-(7-(2-hydroxy-2-phenylacetyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-methyl-N-(4-(4-morpholino-7-(pyrimidine-2-yl)-7,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-1H-benzo[d]imidazol-2-amine
1-ethyl-3-(4-(4-morpholino-7-(4-(trifluoromethyl)pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
benzyl 2-(4-(3-ethylurea)phenyl)-4-(1,4-oxazepan-4-yl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
1-ethyl-3-(4-(4-morpholino-7-(4-phenylpyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-morpholino-7-(4-phenylpyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
butyl 4-(4-morpholino-7-(4-phenylpyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylcarbamate
butyl 4-(4-morpholino-7-(4-phenylpyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylcarbamate
tert-butyl 4-morpholino-2-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
4-(2-(1H-indazol-5-yl)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-4-yl)morpholine
1-ethyl-3-(4-(4-(2-methylmorpholine)-7-(thiazol-5-carbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(4-cyano-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(7-(4,6-dimethylpyrimidin-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(7-(5-ftorpirimidinu-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(4,6-dimethylpyrimidin-2-yl)-4-(1,4-oxazepan-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(7-(4-methoxypyridine-2-yl)-4-(1,4-oxazepan-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(4-(1,4-oxazepan-4-yl)-7-(4-(trifluoromethyl)pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(7-(5-ethylpyrimidine-2-yl)-4-(1,4-oxazepan-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(5-ftorpirimidinu-2-yl)-4-(1,4-oxazepan-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
5-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)-1H-benzo[d]imidazol-2(3H)-he
1-(2-AMINOPHENYL)-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
N-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d-2-yl)phenyl)-1H-benzo[d]imidazol-2-amine
1-(2-hydroxyethyl)-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(cyclopropylmethyl)-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(2-cyanoethyl)-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(2,2,2-triptorelin)urea
N-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-1H-imidazol-2-amine
1-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-1H-imidazol-2-amine
3-methyl-6-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-2,4(1H,3H)-dione
1,3-dimethyl-6-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-2,4(1H,3H)-dione
1-cyclobutyl-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(3-cyano-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(7-(5-cyano-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(4-morpholino-7-(quinoline-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-formyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimido the-2-yl)phenyl)urea
1-(4-(7-acetyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(4-morpholino-7-propionyl 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-isobutyryl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(methylsulphonyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(ethylsulfonyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-morpholino-7-(phenylsulfonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
methyl 2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
tert-butyl 2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-tert-butyl 2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-cyclopropyl-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
6-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-2,4(1H,3H)-dione
1-ethyl-3-(4-(4-morpholino-7-(pyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]is eremein-2-yl)phenyl)urea
1-(5-methylisoxazol-3-yl)-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-(2-aminopyrimidine-4-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
4-(2-(2-chloro-1H-benzo[d]imidazol-5-yl)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-4-yl)morpholine
5-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)indolin-2-he
1-(2-(dimethylamino)ethyl)-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(2-methoxyethyl)-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(4-MOholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-neopentylene
1-(2,2-dottorati)-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(2-foradil)-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
methyl 2-(2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)-4-(trifluoromethyl)pyrimidine-5-carboxylate
1-ethyl-3-(4-(4-morpholino-8-oxo-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
6-(7-benzyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)hinzelin-2-amine
1-ethyl-3-(2-fluoro-4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)Fe who yl)urea
(S)-1-ethyl-3-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(1-methyl-1H-pyrazole-5-carbonyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-nicotinoyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(thiazol-2-carbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(1-hydroxy-2-methylpropan-2-yl)-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-((1S,2S)-2-hydroxycyclopent)-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(3-methylisoxazol-5-yl)-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(isoxazol-3-yl)-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
N-ethyl-5-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)-1H-benzo[d]imidazol-2-amine
(S)-1-(4-(7-(1-acetylpiperidine-4-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(1-methylpiperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-6-(4-(7-benzyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)penilai is about)-3-methylpyrimidine-2,4(1H,3H)-dione
(R)-tert-butyl 2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(R)-1-ethyl-3-(4-(4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-1-ethyl-3-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-nicotinoyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(thiazol-2-carbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-tert-butyl 4-(3-ethylmorpholino)-2-(4-(3-ethylurea)phenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(R)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-tert-butyl 2-(4-(1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-ylamino)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-(4-(7-(3-cyano-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(4-(7-acetyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-propionyl 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-formyl-4-(3-methyl is morpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(pyridin-4-yl)urea
(R)-1-ethyl-3-(5-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)pyridine-2-yl)urea
tert-butyl 2-(2-aminopyrimidine-5-yl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-ethyl-3-(4-(7-(1-methyl-1H-pyrazole-5-carbonyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
methyl 2-(2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)-6-methylpyrimidin-4-carboxylate
2-(2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)-6-methylpyrimidin-4-carboxylic acid
1-ethyl-3-(4-(4-morpholino-7-(4-morpholinopropan-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(4,6-dimethoxypyrimidine-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
2-(2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)-4-(trifluoromethyl)pyrimidine-5-carboxylic acid
2-(2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)-4-(trifluoromethyl)pyrimidine-5-carboxylic acid
1-(4-(7-(1-cyclopropylidene-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
6-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-(1H)-he
(S)-1-(4-(7-(4-cyano-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(4-(7-(5-cyano-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(4-(7-(4,6-dimethylpyrimidin-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(7-(5-ethylpyrimidine-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
6-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-2(1H)-he
1-ethyl-3-(4-(4-morpholino-7-(5-nitropyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(4-amino-5-cyanopyrimidine-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(7-(4-hydroxycyclohexyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-3-methyl-6-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-2,4(1H,3H)-dione
(S)-6-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)-3-methylpyrimidine-2,4(1H,3H)-dione
(S)-3-methyl-6-(4-(4-(3-methylmorpholine)-7-(thiazol-2-carbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-2,4(1H,3H)-dione
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-8-oxo-5,6,7,8-tetrahydropyrido[3,4-d]p is rimidine-2-yl)phenyl)urea
2-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridin-4(1H)-he
1-((1S,2R)-2-hydroxycyclopent)-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
tert-butyl 2-(4-(3-ethylurea)phenyl)-4-(pyridin-4-yl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
1-ethyl-3-(4-(7-(3-methyloxiran-3-carbonyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
2-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-4(3H)-he
(S)-3-methyl-6-(4-(4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-2,4(1H,3H)-dione
(S)-2-(2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)-N,N-dimethylacetamide
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(methylsulphonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-methyl 2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-ethyl 2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(3-hydroxycyclopent)-3-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(5-fluoro-4-hydroxypyrimidine-2-yl)-4-morpholino-56,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(5-aminopyridin-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(7-(4-amino-5-nitropyrimidin-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-3-(ethylamino)-4-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)cyclobuta-3-ene-1,2-dione
(S)-1-(2-cyanoethyl)-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(2-hydroxyethyl)-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-cyclobutyl-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(2,2-dottorati)-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(2-foradil)-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(2,2-dottorati)-3-(4-(4-(3-methylmorpholine)-6-(thiazol-2-carbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(pyrazin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(2-morpholino-2-oxoethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(4-amino-5-methylpyrimidin-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]PI is kidin-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(7-(1-(methylsulphonyl)piperidine-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-morpholino-7-(piperidine-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-cyclobutyl-3-(4-(4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-((1S,2S)-2-hydroxycyclopent)-3-(4-(4-((8)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(2,2-dottorati)-3-(4-(4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-((1S,2S)-2-hydroxycyclopent)urea
(S)-1-(2,2-dottorati)-3-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(2-foradil)-3-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-((1S,2S)-2-hydroxycyclopent)-3-(4-(4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(2,2-dottorati)-3-(4-(4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-((8)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-((1S,2S)-2-hydroxycyclopent)urea
(S)-1-(2,2-dottorati)-3-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-(3-what ethylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(2-foradil)-3-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-cyclobutyl-3-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(2-foradil)-3-(4-(4-(3-methylmorpholine)-7-nicotinoyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-((1S,2S)-2-hydroxycyclopent)-3-(4-(4-((S)-3-methylmorpholine)-7-nicotinoyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(2,2-dottorati)-3-(4-(4-(3-methylmorpholine)-7-nicotinoyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(2-cyanoethyl)-3-(4-(4-(3-methylmorpholine)-7-nicotinoyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-cyclobutyl-3-(4-(4-(3-methylmorpholine)-7-nicotinoyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-cyclobutyl-3-(4-(4-(3-methylmorpholine)-7-(pyrazin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(4-((S)-3-methylmorpholine)-7-(pyrazin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-((S)-tetrahydrofuran-3-yl)urea
(S)-1-ethyl-3-(4-(7-(5-ftorpirimidinu-4-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(2-foradil)-3-(4-(4-(3-methylmorpholine)-7-(pyrazin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-2-(4-(4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]p is rimidine-2-yl)phenylamino)pyrimidine-4(3H)-he
1-ethyl-3-(4-(4-morpholino-7-(pyrimidine-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(3-methylisoxazol-5-yl)-3-(4-(4-(3-methylmorpholine)-7-(pyrazin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-isopropyl 2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-isobutyl 2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(3-methyloxiran-3-carbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(tetrahydrofuran-3-carbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(tetrahydrofuran-2-carbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-formyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(2-hydroxyethyl)urea
(S)-1-(4-(7-formyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(2,2,2-triptorelin)urea
(S)-1-(4-(7-acetyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(2-hydroxyethyl)urea
(S)-1-(4-(7-acetyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(2,2,2-triptorelin)urea
(S)-1-(2-hydroxyethyl)-3-(4-(4-(3-methylmorpholine)-7-propionyl 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)machev is on
(S)-1-(4-(4-(3-methylmorpholine)-7-propionyl 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(2,2,2-triptorelin)urea
(S)-1-(isoxazol-3-yl)-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(1-methyl-1H-pyrazole-5-yl)-3-(4-(4-(3-methylmorpholine)-7-nicotinoyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-2-(4-(4-(3-methylmorpholine)-7-nicotinoyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-4(3H)-he
(S)-1-methyl-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)-1H-1,2,4-triazole-5(4H)-he
(S)-6-(4-(4-(3-methylmorpholine)-7-nicotinoyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-2(1H)-he
(S)-6-(4-(4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-2(1H)-he
(S)-tert-butyl 4-(3-ethylmorpholino)-2-(4-(3-(2-hydroxyethyl)ureido)phenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(6-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(5-ftorpirimidinu-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(4-(trifluoromethyl)pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(4-methoxypyridine-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(2-hydroxyethyl)-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(2-cyanoethyl)-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-cyclobutyl-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(isoxazol-3-yl)-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-tert-butyl 2-(4-(3-ethylurea)phenyl)-4-(3-isopropylaniline)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-(4-(4-(3-ethylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(2-hydroxyethyl)urea
(S)-2-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-4(3H)-he
(S)-2-(4-(4-(3-methylmorpholine)-7-(1,4,5,6-tetrahydropyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-4(3H)-he
(S)-1-(1-methyl-1H-pyrazole-5-yl)-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(3-methylisoxazol-5-yl)-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(1-methyl-1H-pyrazole-3-yl)-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(4-(3-ethylmorpholino)-7-(Piri is one-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(2-hydroxyethyl)urea
(S)-1-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(1-methyl-1H-pyrazole-5-yl)urea
(S)-1-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(3-methylisoxazol-5-yl)urea
(S)-1-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(1-methyl-1H-pyrazole-3-yl)urea
(S)-1-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(isoxazol-3-yl)urea
(S)-1-(4-(7-(4-chloro-1,3,5-triazine-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(1,3,5-triazine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-isopropyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-isobutyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
tert-butyl 3-(2-(4-(3-ethylurea)phenyl)-4-((S)-3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)pyrrolidin-1-carboxylate
1-ethyl-3-(4-(4-((S)-3-methylmorpholine)-7-(pyrrolidin-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-methyl-4-(3-methylmorpholine)-8-oxo-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(1-methyl-1H-pyrazole-4-and sulfonyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(2-methyl-4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-morpholino-7-pivaloyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-2-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-4(3H)-he
1-ethyl-3-(4-(7-(4-perbenzoic)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(4-chlorobenzoyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(7-(2-methylnicotinoyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(6-methylnicotinoyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
isopropyl 2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
isobutyl 2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
1-ethyl-3-(4-(7-(6-methylpyrimidin-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(1-methylcyclopropyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-(1-cyanocyclohexyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(7-(3-hydroxy-2,2-dimethylpropanoyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(6-cyanopyridine-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(7-(1-acetylpyrrolidine-3-yl)-4-((8)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(4-((S)-3-methylmorpholine)-7-(1-(methylsulphonyl)pyrrolidin-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-(1-cyclopropylidene-4-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(tetrahydro-2H-Piran-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-((R)-2-hydroxypropanoyl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-((R)-2-hydroxybutanoic)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-((S)-3-methylmorpholine)-7-(1-(methylsulphonyl)pyrrolidin-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-(1-cyclopropylidene-4-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(tetrahydro-2H-Piran-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-((R)-2-hydroxypropanoyl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-((R)-2-hydroxybutanoic)-4-((S)-3-metalmorph the Lino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-methyl-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-((8)-2-hydroxypropanoyl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-((S)-2-hydroxybutanoic)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(6-chloropyrazine-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(7-isopropyl-4-(3-methylmorpholine)-8-oxo-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(2-methoxypyridine-4-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(2-(trifluoromethyl)pyrimidine-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-(2,6-dimethoxypyrimidine-4-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(7-(3-cyanopyridine-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(7-((R)-2-hydroxy-3-methylbutanoyl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-methyl-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(3-chloropyrazine-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-the Teal-3-(4-(4-morpholino-7-(pyrazin-2-carbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(5-methyl-1,3,4-oxadiazol-2-yl)-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-((S)-2-hydroxy-3-methylbutanoyl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(2-methoxyacetyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-(2-cyanoacetyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-6-(4-(7-(2-hydroxy-2-methylpropanoyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-2(1H)-he
1-ethyl-3-(4-(4-morpholino-7-(pyrimidine-2-carbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-methyl-3-(4-(4-(3-methylmorpholine)-7-(6-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(1-methyl-1H-pyrazole-4-yl)-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-6-(4-(4-(3-methylmorpholine)-7-nicotinoyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrazin-2(1H)-he
(S)-6-(4-(4-(3-methylmorpholine)-7-nicotinoyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrazin-2(1H)-he
1-ethyl-3-(4-(7-(2-((S)-3-ftorpirimidinu-1-yl)-2-oxoethyl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-tert-butyl 2-(4-(3-ethylurea)phenyl)-4-(3-(hydroxymethyl)mo is folino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
1-ethyl-3-(4-(7-(2-((R)-3-ftorpirimidinu-1-yl)-2-oxoethyl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(3-chloropyrazine-2-carbonyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(7-(2-(2-methoxyethoxy)acetyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(5-methyl-1,3,4-oxadiazole-2-carbonyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-6-(4-(4-(3-methylmorpholine)-7-(2,2,2-triptorelin)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-2(1H)-he
(S)-N-ethyl-2-(2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)ndimethylacetamide
(S)-methyl 2-(2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)acetate
(S)-2-(2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)-N-(2-hydroxyethyl)ndimethylacetamide
1-(4-(7-(5-chloropyrazine-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-tert-butyl 2-(4-(3-ethylurea)phenyl)-8,8-dimethyl-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
1-ethyl-3-(4-(4-morpholino-7-(2,2,2-triptorelin)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
tert-butyl 2-(4-(3-ethylurea)phenyl)-8-methyl-4-((S)-3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate (S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(2-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(4-chloro-6-methylpyrimidin-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(7-(2-chloro-6-methylpyrimidin-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
tert-butyl 2-(4-(3-ethylurea)phenyl)-8-methyl-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-(4-(8,8-dimethyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(R)-tert-butyl 2-(4-(3-ethylurea)phenyl)-8-methyl-4-((S)-3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-tert-butyl 2-(4-(3-ethylurea)phenyl)-8-methyl-4-((S)-3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-2-(2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)ndimethylacetamide
(S)-2-(2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)-N-methylacetamide
(S)-2-(2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)-N-propylacetamide
(S)-N-cyclobutyl-2-(2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)ndimethylacetamide
(S)-N-cyclopentyl-2-(2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)ndimethylacetamide
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(2-oxo-2-(PI who Raiden-1-yl)ethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-2-(2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)acetic acid
(S)-1-(4-(7-(2-aminoacetyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(7-((R)-2-aminopropanol)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(7-((R)-2-aminobutanol)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(4-((S)-3-methylmorpholine)-7-(pyrrolidin-2-carbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(2-(methylamino)propanol)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-(2-amino-2-methylpropanoyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-2-(4-(4-(3-methylmorpholine)-7-(6-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-4(3H)-he
(S)-6-bromo-2-(4-(4-(3-ethylmorpholino)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-4(3H)-he
(S)-1-methyl-3-(4-(4-(3-methylmorpholine)-7-(6-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)-1H-1,2,4-triazole-5(4H)-he
1-(4-(7-((S)-2-aminobutanol)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S,E)-2-cyano-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydro the pyrido[3,4-d]pyrimidine-2-yl)phenyl)guanidine
1-ethyl-3-(4-((S)-8-methyl-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
tert-butyl 2-(4-(3-ethylurea)phenyl)-8,8-dimethyl-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
1-(4-(7-((S)-2-aminopropanol)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-2-(4-(4-(3-ethylmorpholino)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-4(3H)-he
1-ethyl-3-(4-((S)-8-methyl-4-((S)-3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(1-methyl-1H-imidazol-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-6-(4-(4-(3-methylmorpholine)-7-(6-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-2(1H)-he
(S)-1-(4-(7-(cyclopropanesulfonyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-ethyl-4-(3-methylmorpholine)-8-oxo-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(8-methyl-4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-6-(4-(7-acetyl-4-(3-metalor is Olya)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-2(1H)-he
(S)-N,N-diethyl-2-(2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)ndimethylacetamide
(S)-1-(4-(7-(2-(3,3-debtorprovidian-1-yl)-2-oxoethyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-6-(4-(7-isopropyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-2(1H)-he
(S)-tert-butyl 8-allyl-2-(4-(3-ethylurea)phenyl)-4-((S)-3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(R)-tert-butyl 8-allyl-2-(4-(3-ethylurea)phenyl)-4-((S)-3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-ethyl-3-(5-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)pyridine-2-yl)urea
(S)-1-ethyl-3-(5-(4-(3-methylmorpholine)-7-(6-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)pyridine-2-yl)urea
(S)-2-(5-(4-(3-methylmorpholine)-7-(6-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)pyridine-2-ylamino)pyrimidine-4(3H)-he
(S)-6-(5-(4-(3-methylmorpholine)-7-(6-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)pyridine-2-ylamino)pyridine-2(1H)-he
(S)-tert-butyl 2-(4-(2-amino-5-methyl-1H-imidazol-1-yl)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-(4-(4-(3-ethylmorpholino)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydro the pyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(isoxazol-3-yl)urea
(S)-1-(4-(4-(3-ethylmorpholino)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(5-methyl-1,2,3-oxadiazol-4-yl)urea
(S)-2-(4-(4-(3-methylmorpholine)-6-(6-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl)phenylamino)pyrimidine-4(3H)-he
1-ethyl-3-(4-(7-(1-methylcyclopropyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(1-cyanocyclohexyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(4-(4-(3-ethylmorpholino)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(oxetan-3-yl)urea
(S)-6-(5-(7-methyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)pyridine-2-ylamino)pyridine-2(1H)-he
(S)-6-(5-(7-methyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)pyridine-2-ylamino)pyridine-2(1H)-he
(S)-6-(5-(7-methyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)pyridine-2-ylamino)pyridine-2(1H)-he
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(thiazol-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-cyclopentyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(4-methylthiazole-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-7-methyl-8-oxo-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(-cyclohexyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(4-(7-(6-chloropyrimidine-4-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(6-methylpyrimidin-4-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(2-methylpyrimidin-4-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-2-yl)phenyl)urea
(S)-1-isopropyl-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(2-methylpyrimidin-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(2,2,2-triptorelin)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(4-((1S,4S)-2-oxa-5-azabicyclo[2,2,1]heptane-5-yl)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(pyrazin-2-carbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-6-(5-(7-isopropyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)pyridine-2-ylamino)pyridine-2(1H)-he
1-ethyl-3-(4-(7-(3-methyl-1,2,4-thiadiazole-5-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(1-methyl-1H-imidazol-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(5-methylpyrazine-2-carbonyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)who Icewine
1-(4-(7-(6-cyclopropylamino-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(7-(1-methyl-6-oxo-1,6-dihydropyridines-2-yl)-4-morpholino-5,6,7,8-Tetra-hydroperiod[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(5-methylpyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(4-((1S,4S)-2-oxa-5-azabicyclo[2,2,1]heptane-5-yl)-7-(6-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(4-((1S,4S)-2-oxa-5-azabicyclo[2,2,1]heptane-5-yl)-7-(5-ftorpirimidinu-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(4-((1S,4S)-2-oxa-5-azabicyclo[2,2,1]heptane-5-yl)-7-(2-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(7-(3-methylpyridin-2-carbonyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-cyclobutyl-3-(4-(4-(3-ethylmorpholino)-7-(2-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-7-(5-ftorpirimidinu-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(ethylsulfonyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(isopropylphenyl)-4-(3-metalmorph the Lino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-methyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(5-methyl-1,3,4-oxadiazol-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-(5-cenotesa-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(4-((S)-3-methylmorpholine)-7-(tetrahydrofuran-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(isobutylphenyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(3-methyl-1,2,4-thiadiazole-5-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-6-(4-(7-(1-methyl-1H-imidazol-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-2(1H)-he
(S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-7-(2,2,2-triptorelin)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-(cyclopropylmethyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(pyridine-4-ylmethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-ethyl-4-(3-ethylmorpholino)-8-oxo-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(3-hydroxy-2,2-dimethylpropyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)br/> (S)-7-ethyl-4-(3-ethylmorpholino)-2-(4-(6-oxo-1,6-dihydropyridines-2-ylamino)phenyl)-6,7-dihydropyrido[3,4-d]pyrimidine-8(5H)-he
1-(4-((R)-7-acetyl-8-methyl-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-((R)-7-ethyl-8-methyl-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-((8)-7-ethyl-8-methyl-4-((8)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-((R)-7,8-dimethyl-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-((S)-7,8-dimethyl-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(util-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(propylsulfonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-1-ethyl-3-(4-(8-methyl-7-(2-methylpyrimidin-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(8-methyl-7-(2-methylpyrimidin-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(8-methyl-7-(2-methylpyrimidin-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(1-methyl-6-oxo-1,6-dihydropyridines-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(6-(benzyloxy)pyridine-2-is)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(4-(7-(3,3-dimethylbutyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(4-(7-(5-ftorpirimidinu-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-metalmachine
(S)-1-(4-(7-(6-chloro-2-methylpyrimidin-4-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-metalmachine
1-ethyl-3-(4-(4-morpholino-7-(6-oxo-1,6-dihydropyridines-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-((8)-3-methylmorpholine)-7-((tetrahydrofuran-3-yl)methyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-((S)-7-acetyl-8-methyl-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-((6-methylpyridin-2-yl)methyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-methyl-3-(4-(4-(3-methylmorpholine)-7-(2-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-((R)-8-allyl-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-((S)-8-allyl-4-((8)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-((R)-7-acetyl-8-allyl-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-((S)-7-acetyl-8-allyl-4-((8)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-etil-(4-(4-((S)-3-methylmorpholine)-7-(((R)-tetrahydrofuran-3-yl)methyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-((6-methylpyridin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-4-(3-methylmorpholine)-2-(4-(6-oxo-1,6-dihydropyridines-2-ylamino)phenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carbaldehyde
(S)-6-(4-(7-ethyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-2(1H)-he
(S)-6-(4-(7-ethyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-2(1H)-he
1-ethyl-3-(4-(4-((S)-3-methylmorpholine)-7-((tetrahydrofuran-2-yl)methyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-N-ethyl-4-(3-methylmorpholine)-2-(4-(6-oxo-1,6-dihydropyridines-2-ylamino)phenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxamide
(S)-1-ethyl-3-(4-(7-(1-ethyl-1H-imidazol-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(trifloromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-((S)-3-methylmorpholine)-7-(((S)-tetrahydrofuran-2-yl)methyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-((S)-3-methylmorpholine)-7-(((R)-tetrahydrofuran-2-yl)methyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-neopentyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-6-(4-(7-(1-ethyl-1H-imidazol-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]PI is kidin-2-yl)phenylamino)pyridine-2(1H)-he
(S)-tert-butyl 2-(2-aminopyrimidine-5-yl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-5-(4-(3-methylmorpholine)-7-(2-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)pyrimidine-2-amine
(S)-5-(7-(5-ftorpirimidinu-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)pyrimidine-2-amine
(S)-5-(7-isopropyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)pyrimidine-2-amine
(S)-2-(4-(7-isopropyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-4(3H)-he
1-ethyl-3-(4-(7-(5-ftorpirimidinu-2-yl)-4-(4-methoxypiperidine-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-2-(4-(7-ethyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyrimidine-4(3H)-he
1-ethyl-3-(4-(7-(1-methyl-6-oxo-1,6-dihydropyridines-3-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-6-(4-(4-(3-methylmorpholine)-7-(2-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-2(1H)-he
(S)-6-(4-(7-(5-ftorpirimidinu-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-2(1H)-he
(S)-6-(4-(7-(2-hydroxyethyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-2(1H)-he
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(pyridine-3-ylmethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-((1,3-dioc the olan-2-yl)methyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-7-isopropyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-acetyl-4-(3-ethylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-7-formyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(2-methoxyethyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(2-methoxyethyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-((2-methylpyridin-4-yl)methyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-ethyl-4-(3-ethylmorpholino)-8-oxo-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(isoxazol-3-yl)urea
(S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-7-(methylsulphonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-6-(4-(7-(2-methoxyethyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenylamino)pyridine-2(1H)-he
1-(4-(7-(5,5-dimethyltetrahydrofuran-3-yl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(7-(5,5-dimethyltetrahydrofuran-3-yl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahed is pyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(7-ethyl-4-(3-ethylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-7-(trifloromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-tert-butyl 8-(cyanomethyl)-2-(4-(3-ethylurea)phenyl)-4-((S)-3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-6-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl)phenyl)urea
tert-butyl 8-(2-amino-ethyl)-2-(4-(3-ethylurea)phenyl)-4-((S)-3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-7-(tetrahydro-2H-Piran-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea.
(S)-1-ethyl-3-(4-(7-(2-hydroxy-2-methylpropyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(pyrimidine-2-ylmethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-(2,2-dottorati)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-tert-butyl 4-(3-methylmorpholine)-2-(4-(3-oxetan-3-yureina)phenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
5-methyl-n-(4-(4-morpholino-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-4,5-dihydro-1H-imidazol-2-amine
(S)-1-(4-(7-(2-tert-butoxyethyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-e is rocephine
1-ethyl-3-(4-(4-((S)-3-methylmorpholine)-7-(1-(pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-(2-methoxyethyl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(isoxazol-3-yl)-3-(4-(7-methyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-ethyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(isoxazol-3-yl)urea
(S)-1-(1-methyl-1H-pyrazole-4-yl)-3-(4-(7-methyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(5-methyl-1,3,4-oxadiazol-2-yl)-3-(4-(7-methyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-ethyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(1-methyl-1H-pyrazole-4-yl)urea
(S)-1-(4-(7-ethyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(5-methyl-1,3,4-oxadiazol-2-yl)urea
(S)-tert-butyl 4-(3-methylmorpholine)-2-(2-oxo-1,2-dihydroquinoline-6-yl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-6-(7-isopropyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)quinoline-2(1H)-he
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-((tetrahydro-2H-Piran-4-yl)methyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-((S)-8-(cyanomethyl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-4-((R)-8-(cyanomethyl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-((R)-8-(cyanomethyl)-7-ethyl-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-((S)-8-(cyanomethyl)-7-ethyl-4-((8)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(7-(2-methoxyethyl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-1-ethyl-3-(4-(7-(2-methoxyethyl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-1-ethyl-3-(4-(7-(2-methoxyethyl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-(2-cyclopropylethyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-((R)-8-(cyanomethyl)-7-isopropyl-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-((S)-8-(cyanomethyl)-7-isopropyl-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-l-ethyl-3-(4-(7-(1-methyl-2-oxo-1,2-dihydropyridines-4-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-isopropyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(1-methyl-1H-pyrazole-4-yl)urea
(S)-1-(4-(7-isopropyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(5-methyl-1,3,4-oxadiazol-2-yl)urea
(S)-1-(4-(7-isopropyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-the l)phenyl)-3-(5-methylisoxazol-3-yl)urea
(S,E)-tert-butyl 8-(4-ethoxy-4-exabot-2-enyl)-2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(R,E)-tert-butyl 8-(4-ethoxy-4-exabot-2-enyl)-2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-tert-butyl 8-(4-ethoxy-4-oxobutyl)-2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(R)-tert-butyl 8-(4-ethoxy-4-oxobutyl)-2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-(4-(7-((1,3-dioxane-2-yl)methyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(7-((1,3-dioxolane-2-yl)methyl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(7-(2-fluoro-2-methylpropyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-((2-methylpyrimidin-5-yl)methyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-((1-methyl-1H-pyrazole-5-yl)methyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-isopropyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(isoxazol-3-yl)urea
(S)-1-(4-(7-(5-ftorpirimidinu-2-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(isoxazol-3-yl)urea
(S)-tert-butyl 2-(3-(hydroxy shall ethyl)-4-methoxyphenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-(4-(7-methyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(5-methylisoxazol-3-yl)urea
(S)-1-(4-(7-ethyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(5-methylisoxazol-3-yl)urea
1-ethyl-3-(4-(7-(1-methoxypropan-2-yl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-((S)-3-methylmorpholine)-7-(tetrahydro-2H-Piran-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-((S)-3-methylmorpholine)-7-(tetrahydro-2H-Piran-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(4-(3,3-dimethylmorpholine)-7-(2-methoxyethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-tert-butyl 2-(4-(1H-imidazol-2-ylamino)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-ethyl-3-(4-(7-((1-ethyl-1H-pyrazole-5-yl)methyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-((R)-2-hydroxypropyl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-(2-ethoxyethyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(7-(3-hydroxy-3-methylbutyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-((S)-2-hydroxypropyl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimido the-2-yl)phenyl)urea
1-ethyl-3-(4-(4-((S)-3-methylmorpholine)-7-((R)-tetrahydrofuran-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-(4-(7-(((R)-2,2-dimethyl-1,3-dioxolane-4-yl)methyl)-4-((8)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-tert-butyl 8-(cyanomethyl)-2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(R)-tert-butyl 8-(cyanomethyl)-2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-ethyl-3-(4-(7-((2-methyl-1,3-dioxolane-2-yl)methyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(2-hydroxyethyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(3-hydroxypropyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(3-methoxypropyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-1-(4-(7-((1,3-dioxolane-2-yl)methyl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(4-(7-((1,3-dioxolane-2-yl)methyl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-4-(2-(lH-indol-5-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-4-yl)-3-methylmorpholin
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(2-(methylsulphonyl)ethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)machev is on
(S)-1-(4-(4-(3-methylmorpholine)-7-(6-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(oxetan-3-yl)urea
1-(4-(4-((1R,5S)-3-oxa-8-azabicyclo[3,2,1]Octan-8-yl)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(4-(7-(2-cyanoethyl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-tert-butyl 2-(1H-indol-5-yl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
1-ethyl-3-(4-(7-(2-methoxypyridine-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-morpholino-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-e]pyrimidine-2-yl)phenyl)urea
1-(4-(7-((R)-2,3-dihydroxypropyl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(4-((1R,5S)-3-oxa-8-azabicyclo[3,2,1]Octan-8-yl)-7-(6-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-R-(4-(7-isopropyl-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-1H-imidazol-2-amine
(S)-M-(4-(4-(3-methylmorpholine)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-1H-imidazol-2-amine
(S)-1-ethyl-3-(4-(7-(3-forproper)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-methyl 3-(2-(4-(3-ethylurea)phenyl)-4-(3-methylmorpholine)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-yl)propanoate
1-(4-(4-((1R,5S)-8-oxa-3-azab the cyclo[3,2,1]Octan-3-yl)-7-(pyrimidine-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(4-((1R,5S)-8-oxa-3-azabicyclo[3,2,1]Octan-3-yl)-7-(6-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(4-((1R,5S)-8-oxa-3-azabicyclo[3,2,1]Octan-3-yl)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido [3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(4-((1R,5S)-8-oxa-3-azabicyclo[3,2,1]Octan-3-yl)-7-isopropyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(8-methyl-4-morpholino-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(8-methyl-4-morpholino-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-1-ethyl-3-(4-(8-methyl-4-morpholino-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-(2-methylmorpholine)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
tert-butyl 4-((1R,5S)-8-oxa-3-azabicyclo[3,2,1]Octan-3-yl)-2-(4-(3-ethylurea)phenyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-4-(2-(1H-indol-5-yl)-7-(1-(pyridine-3-ylmethyl)piperidine-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-4-yl)-3-methylmorpholin
1-(4-(4-((1R,5S)-3-oxa-8-azabicyclo[3,2,1]Octan-8-yl)-7-isopropyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(4-(7-(6-chloro-2-methylpyrimidin-4-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(isoxazol-3-yl)urea
(S)-1-(4-(7-(2-chloro-6-methylpyrimidin-4-yl)-4-(3-methylmorpholine)-5,6,7,8-tet is hydroperiod[3,4-d]pyrimidine-2-yl)phenyl)-3-(isoxazol-3-yl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-((3-methyloxiran-3-yl)methyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-tert-butyl 2-(4-(3-ethylurea)phenyl)-8-(2-hydroxyethyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-tert-butyl 2-(4-(3-ethylurea)phenyl)-8-(2-hydroxyethyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(R)-tert-butyl 2-(4-(3-ethylurea)phenyl)-8-(2-hydroxyethyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-1-ethyl-3-(4-(8-(2-hydroxyethyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-1-ethyl-3-(4-(8-(2-hydroxyethyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-(2-(dimethylamino)pyrimidine-4-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(4-(7-(2,6-dimethoxypyrimidine-4-yl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(R)-1-(4-(7-(2,6-dimethoxypyrimidine-4-yl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(4-(7-(2-chloro-6-methylpyrimidin-4-yl)-3-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(R)-1-(4-(7-(2-chloro-6-methylpyrimidin-4-yl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-(4-(7-(2,6-dimethylpyrimidin-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]Piri is one-2-yl)phenyl)-3-atilmotin
(R)-1-(4-(7-(2,6-dimethylpyrimidin-4-yl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(4-(7-(2,6-dimethylpyrimidin-4-yl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(4-(7-(4-chloro-6-methylpyrimidin-2-yl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(R)-1-(4-(7-(4-chloro-6-methylpyrimidin-2-yl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(isoxazol-3-yl)-3-(4-(4-(3-methylmorpholine)-7-(2-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-isopropyl-3-(4-(4-(3-methylmorpholine)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(3-forproper)-3-(4-(4-(3-methylmorpholine)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(isoxazol-3-yl)-3-(4-(4-(3-methylmorpholine)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(8-(2-hydroxyethyl)-7-(2-methylpyrimidin-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-l-ethyl-3-(4-(8-(2-hydroxyethyl)-7-(2-methylpyrimidin-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(8-(2-hydroxyethyl)-7-(2-methoxyethyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-a]pyrimidine-2-yl)phenyl)urea
(R)-1-ethyl-3-(4-(8-(2-hydroxyethyl)-7-(2-methoxy what Teal)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(8-(2-hydroxyethyl)-7-(6-methylpyrimidin-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(8-methyl-7-(6-methylpyrimidin-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-1-ethyl-3-(4-(8-methyl-7-(6-methylpyrimidin-4-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(5-ftorpirimidinu-2-yl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-1-ethyl-3-(4-(7-(5-ftorpirimidinu-2-yl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(5-methyl-1,3,4-oxadiazol-2-yl)-3-(4-(4-(3-methylmorpholine)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(5-methylisoxazol-3-yl)-3-(4-(4-(3-methylmorpholine)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(1-methyl-1H-pyrazole-4-yl)-3-(4-(4-(3-methylmorpholine)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(8-methyl-4-morpholino-7-(pyrimidine-2-ylmethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-1-ethyl-3-(4-(8-methyl-4-morpholino-7-(pyrimidine-2-ylmethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(R)-1-(4-(7-(5-cyano-2-yl)-8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
1-ethyl-3-(4-(4-((S)-3-methylmorpholine)-7-((S)-tetrahydrofuran-3-yl)-5,6,,8 tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(4-((S)-3-methylmorpholine)-7-((S)-tetrahydrofuran-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(3-oxocyclohexa-1-enyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(6-methylpyridazin-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(4-(3-methylmorpholine)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-(oxetan-3-yl)urea
1-ethyl-3-(4-(4-(2-(methoxymethyl)morpholino)-7-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-(2,6-dimethylpyrimidin-4-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-ethyl-3-(4-(7-(1-methylisatin-3-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(1-methyl-6-oxo-1,6-dihydropyridines-3-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(3-oxocyclopent-1-enyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
1-ethyl-3-(4-(7-((S)-2-methoxypropyl)-4-((S)-3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-methyl-3-(4-(4-(3-methylmorpholine)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(5-oxo-2,5-dihydrofuran-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]is eremein-2-yl)phenyl)urea
(R)-tert-butyl 8-ethyl-2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
(S)-tert-butyl 8-ethyl-2-(4-(3-ethylurea)phenyl)-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate.
(S)-1-ethyl-3-(4-(4-(3-methylmorpholine)-7-(pyridazin-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(4-(7-(6-chloropyridin-3-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin.
(S)-1-(4-(7-(azetidin-3-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)-3-atilmotin
(S)-1-(3,4-differenl)-3-(4-(4-(3-methylmorpholine)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-ethyl-3-(4-(7-(6-methoxypyridazine-3-yl)-4-(3-methylmorpholine)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea
(S)-1-(isoxazol-3-yl)-3-(4-(4-(3-methylmorpholine)-7-(6-methylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2-yl)phenyl)urea.

29. Pharmaceutical composition having the properties of an inhibitor of mTOR kinase, containing an effective amount of a compound of formula I and pharmaceutically acceptable carrier, diluent or excipient.

30. A method of inhibiting the activity of mTOR kinase, including the introduction of a therapeutically acceptable amount of a compound according to claim 1.

31. The method according to item 30, where the specified connection according to claim 1 selectively inhibits mTORC1 consider is Ino mTORC2.

32. The method according to item 30, where the specified connection according to claim 1 selectively inhibits mTORC2 relative to mTORC1.

33. The use of compounds according to claim 1, for obtaining a medicinal product for the treatment of malignant tumors mediated by the activity of mTOR kinase.



 

Same patents:

FIELD: chemistry.

SUBSTANCE: described are novel substituted naphthyridines of general formula E: (radicals R1 and R3 are described in the claim), pharmaceutically acceptable salts thereof, a pharmaceutical composition containing said compounds, and use of the novel compounds to prepare a medicinal agent for treating or preventing malignant tumours in mammals.

EFFECT: compounds inhibit Akt acitivity, in particular, the compounds selectively inhibit one or two isoforms of Akt and can be used in medicine.

5 cl, 14 tbl, 9 ex

FIELD: medicine.

SUBSTANCE: there are described new compounds of general formula

where Xa represents 2 to 4 condensed cycloalkyl, aryl, heterocyclic rings containing 1 to 2 heteroatoms, chosen of N and O, and heteroaryl rings containing 1 to 4 heteroatoms, chosen of N, O or S where said rings can be additionally substituted. (Radical values R1-R4, R1, Y and n are specified in the patent claim), specific representatives of said compounds and a pharmaceutical composition containing them.

EFFECT: new compounds are effective in stimulation of endogenous development or release of growth hormone and can be used in treating obesity, osteoporosis and for increasing muscle bulk and muscle strength.

17 cl, 339 ex, 10 tbl

The invention relates to tetracyclic analogues of camptothecins formula (I), where R1, R2, R3, R4, R5and R10such as defined in the claims

FIELD: chemistry.

SUBSTANCE: in general formula 1 , a cyclic ring can be selectively formed; each of R1 and R2 is independently selected from a group consisting of hydrogen, with a straight or branched alkyl chain having 1-6 carbon atoms and phenetyl or R1 and R2 together form a 5- or 6-member heterocyclic ring or R1 and R2 together with Ar1 form a bicyclic ring; Ar1 is selected from a group consisting of furanyl, thionyl, methylene dioxyphenyl and phenyl, which can be substituted with at least one identical or different substitutes selected from a group consisting of hydrogen, with a straight or branched alkyl chain having 1-6 carbon atoms, a halogen such as F, O and Br, with a straight or branched alkoxy chain, having 1-6 carbon atoms, nitro and trifluoromethyl; Z is hydrogen or fluorine, or taken together with Ar1 forms a bicyclic ring; Ar2 is selected from a group consisting of phenyl, methylene dioxyphenyl, pyridine pyrimidine, naphthyl, bis(fluorophenyl)methyl and quinoxaline, which can be substituted with at least one identical or different substitutes selected from a group consisting of hydrogen, with a straight or branched alkyl chain, having 1-6 carbon atoms, hydroxy, halogen, with a straight or branched alkoxy chain having 1-6 carbon atoms, nitro, acetyl, tert-butyl acetate, trifluoromethyl, amino and acetate; n is equal to 1 or 2; m is an integer from 0 to 2.

EFFECT: improved method.

26 cl, 2 dwg, 2 tbl, 87 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new compounds of general formula 1, or their pharmaceutically acceptable salts showing the properties of incretin secretagogues, preferentially the properties of a bile acid receptor TGR5 agonist. The compounds are applicable for treating metabolic diseases associated with glucose metabolism, such as diabetes, obesity, metabolic syndrome, etc. In formula 1 R1, R2 and R3 independently represent a cyclic system substitute specified in: hydrogen, C1-C3alkyl, halogen, a trifluoromethyl group, C1-C3alkoxy, a cyano group, a trifluoromethoxy group; an amino group substituted by C1-C3alkyl; or two radicals R3, found at carbon neighbours in a benzene ring, together with the benzene ring bound therewith form 3,4-methylene dioxyphenyl; R4 represents hydrogen, C1-C5alkyl, a carboxyl group, C1-C3alkoxycarbonyl or an amide group CONHR5; R5 is an optionally substituted by C1-C3alkyl, C5-C6cycloalkyl optionally substituted by phenyl, benzyl, pyridyl; X and Y represent two hydrogen atoms or an oxygen atom, provided Y=O, then X=2H, provided Y=2H, then X=O or X=Y=2H; the sign (N) shows the possibility of bioisosteric substitution of the benzene ring by the pyridine, pyrimidine, pyridazine, triazine or pyrazine ones.

EFFECT: preparing the pharmaceutical composition and the combined drugs with the use of the compounds of formula 1 or the based pharmaceutical composition and a protein kinase DPP-IV inhibitor specified in Vildagliptin or Sitagliptin, and/or an endogenous bile acid or mied bile acid secretagogues.

53 cl, 7 dwg, 8 ex

FIELD: chemistry.

SUBSTANCE: present invention relates to a method for synthesis of 2-methyl-1-(2-methylpropyl)-1H-imidazo[4.5-c][1.5]naphthyridine-4-amine. The method involves the following: 2-methyl-1-(2-methypropyl)-5-oxido-1H-imidazo[4.5-c][1.5]naphthyridine is obtained in a carrier which contains lower alcohol; the 2-methyl-1-(2-methypropyl)-5-oxido-1H-imidazo[4.5-c][1.5]naphthyridine in the carrier is combined with a reagent which contains ammonia or ammonium and arylsulfonyl halide to form a mixture; and components of the mixture can react in a period of time sufficient for formation of 2-methyl-1-(2-methylpropyl)-1H-imidazo[4.5-c][1.5]naphthyridine-4-amine.

EFFECT: obtaining a new compound.

67 cl, 5 ex

FIELD: chemistry.

SUBSTANCE: present invention relates to ligand with a wide range of simultaneous receptor activity towards adrenergic α1A, α1B , α1D, α1A, α2A, β2, dopamine D1, D21, D2S, D3, serotonin 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, 5- HT7, sigma α1, α2 receptors, to calcium and sodium channels, monoamine transporters [norepinephrine (NET) and dopamine (DAT)], which is 3-methyl-9-benzyl-1,2,3,4-tetrahydrocarbonyl naphthalene-1,5-disulphonate of formula 1:

. The invention also relates to a pharmaceutical composition, which has a medicinal origin, which is a ligand of formula 1 with the given range of simultaneous receptor activity for preventing and/or treating diseases of the central nervous system, pathogenesis of which is related to GPCR receptors, ion channels and monoamine transporters, method of preparing said composition, and to medicinal agents.

EFFECT: range of simultaneous activity towards said receptors increases capacity and effectiveness of using the said ligand.

10 cl, 10 dwg, 7 ex

FIELD: chemistry.

SUBSTANCE: present invention relates to 3-[(3,5-dinitrophenyl)carboxamido]1,4,6-trimethyl-5-chloropyrazolo[3,4-b]pyridine, which exhibits antidote activity towards 2,4- dichlorophenoxyacetic acid on sunflower.

EFFECT: wide range of biologically active substances, obtained synthetically.

1 cl, 3 ex, 1 tbl

The invention relates to compounds of the formula a-b-D-E-F-G, where the values of the radicals presented in the description in all their stereoisomeric forms and their mixtures in all ratios, and their physiologically acceptable salts

The invention relates to a neuroprotective (anti-ischemic and excited by blocking amino acid receptor) analogues 5-(1-hydroxy-2-piperidinophenyl)-2-(1H, 3H)-indole-defined formula (I), (II) and (III) below; their pharmaceutically acceptable salts; method of using these compounds in the treatment of stroke, traumatic brain injury or degenerative diseases of the CNS (Central nervous system), such as disease Alzheimer, senile dementia Alzheimers.com type, Huntington's disease and Parkinson's disease; and some of their intermediates
The invention relates to the production of highly pure substances that are used as reagents, in particular to an improved process for the preparation of 1,10-phenanthroline

FIELD: chemistry.

SUBSTANCE: invention relates to 3-aza-bicyclo[3.3.0]octane derivatives of formula , where R1 and R2 are hydrogen, C1-4alkyl or fluorine; R3 is a phenyl which is unsubstituted, mono- or disubstituted, where the substitutes are independently selected from a group comprising C1-4alkyl, C1-4alkoxy group, trifluoromethyl, trifluoromethoxy group and halogen; 2,3-dihydrobenzofuranyl; 2,3-dihydrobenzo[1,4]dioxynyl; or isoxazolyl, pyridyl, indazolyl, benzofuranyl, benzoxazolyl, benzoisoxazolyl, benzothiazolyl, benzoisothiazolyl, pyrrolo[2,1b]thiazolyl, imidazo[ 1,2-a]pyridinyl or imidazo[2,1-b]thiazolyl, where said groups are unsubstituted, mono- or disubstituted, where the substitutes are independently selected from a group comprising C1-4alkyl, C1-4alkoxy group, halogen and trifluoromethyl; A is or ; R4 is C1-4alkyl or -NR6R7; R6 is hydrogen or C1-4alkyl; R7 is hydrogen or C1-4alkyl; and D is a phenyl which is unsubstituted, mono- or disubstituted, where the substitutes are independently selected from a group comprising C1-4alkyl, C1-4alkoxy group, trifluoromethyl and halogen; or a pharmaceutically acceptable salt of such a compound. 3-aza-bicyclo[3.3.0]octane derivatives or a pharmaceutically acceptable salt thereof are used as a medicinal agent having the activity of orexin receptor antagonists.

EFFECT: novel 3-aza-bicyclo[3,3,0]octane derivatives as nonpeptide antagonists of human orexin receptors.

9 cl, 1 tbl, 85 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to derivatives of antibiotics, which represent compounds of formula (I) and their pharmaceutically acceptable salts, where U, V, W, X, R1, R2, R3, R4, R5, R6, A, B, D, E, G, m and n are determined in description. Invention also relates to pharmaceutical composition, containing said compounds and their application for obtaining medication for prevention or treatment of bacterial infections.

EFFECT: obtaining useful antimicrobial agents, efficient against various pathogens of people and animals.

23 cl, 1 tbl, 186 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention describes specific compounds, namely pyridyl-piperidine compounds, which represent antagonists of orexin receptors and can be used for treatment or prevention of neurologic and psychiatric disorders and diseases, in development of which orexin receptors participate.

EFFECT: claimed invention relates to pharmaceutical compositions, containing said compounds, as well as to application of said compounds and compositions for prevention or treatment of diseases, in development of which orexin receptors participate.

5 cl, 1 ex, 2 tbl

Chemical compounds // 2469034

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention describes compounds of formula (I) wherein: R1 means C1-6alkyl or C3-6cycloalkyl; wherein R1 may be optionally carbon-substituted by one or more R6; R2 means hydrogen; R3 and R4 are carbon substitutes, and each is independently specified in carboxy, carbamoyl, N-(C1-6alkyl)amino, N,N-(C1-6alkyl)2amino, C1-6alkanoylamino, N-(C1-6alkyl)carbamoyl, N,N-(C1-6alkyl)2carbamoyl, N-(C1-6alkoxy)carbamoyl, phenyl-R9 - or heterocyclyl-R10-; wherein R3 and R4 may be independently carbon-substituted by one or more R11; and wherein provided said heterocyclyl contains -NH - residue, then nitrogen may be optionally substituted by a group specified in R12; m has the value of 0, 1 or 2; wherein the values R3 may be equal or different; p has the value of 0, 1 or 2; wherein the values R4 may be equal or different; the ring A means nitrogen-containing 5- or 6-member heterocyclic group; wherein drawn nitrogen represents = N- and is found in an ortho-position to R1R2NC(O)NH group in formula (I); the ring B means phenyl or heterocyclyl; wherein provided said heterocyclyl contains -NH- residue, then nitrogen may be optionally substituted by a group specified in R14; R5 is specified in hydroxy, C1-6alkoxy or -N(R15)(R16); R6 and R11 are carbon substitutes and each is independently specified in halo, C1-6alkyl or C1-6alkoxy; R15 and R16 are independently specified in hydrogen, C1-6alkyl, C1-6alkoxy, cyclopropyl or cyclopentyl; R12 and R14 mean C1-6alkyl; wherein R14 may be optionally carbon specified by one or more R23; R9 and R10 mean a direct link; and R23 means halo or methoxy; wherein said heterocyclyl means pyridine, imidazole, triazole, thiazole, benzothiazole, imodazolepyridine, dihydroquinoline or thiadiazole, or its pharmaceutically acceptable salt; provided said compound represents other than ethyl ester of 5-[2-[[(ethylamino)carbonyl]amino]pyridin-4-yl]-4-methyl-4H-1,2,4-triazole-3-carboxylic acid or their pharmaceutically acceptable salts. There are also described pharmaceutical compositions on the basis of said compounds, a method for bacterial DNA-hydrase and/or bacterial topoisomerase IV inhibition in a homoiothermal animal, as well as a method of treating an infection in a homoiothermal animal.

EFFECT: there are prepared and described new compounds showing antibacterial activity.

24 cl, 165 ex

FIELD: chemistry.

SUBSTANCE: present invention relates to dihydropyrazolone derivatives or of formula (I), where R1 denotes a heteroaryl group of formulae given below, where * denotes the linkage point with the dihydropyrazolone ring, A in each individual occurrence denotes C-R4 or N, wherein at most two ring members A represent N at the same time, E denotes O or S, R2, R3 and R4 are as defined in the claim. The invention also relates to a method of producing said compounds.

EFFECT: compounds of formula (I) inhibit HIF-propylhydroxylase activity and can be used to treat and/or prevent diseases, as well as for producing medicaments for treating and/or preventing diseases, particularly cardiovascular and haematologic diseases, kidney diseases, and for promoting the healing of wounds.

10 cl, 10 tbl, 178 ex

FIELD: chemistry.

SUBSTANCE: invention relates to novel substituted pyrimidine derivatives having PGDS inhibiting properties. In formula (I): (I), R1 denotes phenyl or a 5- or 6-member heteroaryl containing 1-3 heteroatoms selected from N, O and S, each optionally having one or more of the following independent substitutes: halogen, (C1-C6)-alkyl, or (C1-C4)-haloalkyl; R2 denotes hydrogen or (C1-C6)-alkyl, which is optionally substituted with one or more halogens; R3 denotes hydrogen, (C1-C6)-alkyl or phenyl; R4 denotes C6-cycloalkyl, phenyl, a 6-member heterocyclyl containing one N heteroatom, a 6-member heteroaryl containing one N heteroatom, -C(=O)-NY1Y2, -C(=S)-NY1Y2, or -C(=O)-R5, where the phenyl, 6-member heteroaryl or 6-member heterocyclyl group optionally has one or more independent substitutes R6, or R3 and R4 together with a nitrogen atom with which they are bonded form a 5- or 6-member heterocyclyl containing one or two heteroatoms selected from N, O and S, a 6-member heterocyclenyl containing two or three N heteroatoms, a 5-member monocyclic or 9-member bicyclic heteroaryl containing one to three N heteroatoms, phenylheterocyclyl, where the heterocyclyl is 5- or 6-membered and contains one or two heteroatoms selected from N and O, each optionally having one or more independent substitutes R6. Values of R5, R6, Y1, Y2 are given in the claim. The invention also relates to a pharmaceutical composition containing said compounds.

EFFECT: improved method.

15 cl, 227 ex

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of general formula (I) , where R1 denotes an ethoxy group; R2 denotes hydrogen; R3 denotes a cyano group; R4 denotes hydrogen; R5 denotes hydrogen, a methoxy group or an ethoxy group; R6 denotes hydrogen or a methoxy group; R7 denotes hydrogen, methyl, ethyl, n-propyl or isopropyl; X1 denotes -NH-; X2 denotes N or CH; X3 denotes N or CH; where X2 and X3 do not denote N at the same time; and pharmaceutically acceptable salts and tautomeric forms thereof. The invention also relates to a medicinal agent for treating and/or preventing a vasopressin-dependent disease, which contains the compound given in claim 1, use of the compound of formula I to prevent and/or treat vasopressin-dependent diseases, as well as a method of treating and/or preventing said diseases.

EFFECT: novel compounds which can be useful in treating vasopressing-dependent diseases are described.

22 cl, 90 ex, 4 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: it has been confirmed that the new azolcarboxamide compound or its pharmaceutically acceptable salt wherein a thiazole ring or an oxazole ring is bound to a benzene ring, a pyridine ring, a pyridazine ring, a thiophen ring, a pyrazole ring or a pyrrol ring through carboxamide or its ring possess high activity of receptor trkA inhibition; it has been found that they may be used as a therapeutic and/or preventive agent which is different in the fact concerning the effectiveness and safety for repeated urination, frequent micturate urge and urine incontinence associated with various urogenital diseases, including higher bladder activity, various lower bladder diseases accompanied with urogenital pain, such as interstitial cystitis, chronic prostatitis and others, and various diseases accompanied by pain; thereby the present invention has been created.

EFFECT: provided therapeutic and/or preventive agent for repeated urination, frequent micturate urge and urine incontinence associated with various urogenital diseases, including higher bladder activity, various lower bladder diseases accompanied with urogenital pain, such as interstitial cystitis, chronic prostatitis and others, and various diseases accompanied by pain on the basis of excellent inhibitory action on the receptor trkA.

24 cl, 1195 ex, 215 tbl

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