Method for textile treatment for cardiovascular surgery

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to textile treatment for cardiovascular surgery. A method involves textile treatment with a composition containing gelatin and intermolecular cross-linking of gelatin by an aqueous solution of glutaric dialdehyde, an antibiotic and 0.9% sodium chloride in certain proportions.

EFFECT: method enables make textiles hermetic and antimicrobial, reduced postoperative chemotherapeutic load on the patient.

5 cl, 11 tbl, 11 ex

 

The invention relates to medicine, namely to the processing of textile products for cardiovascular surgery in order to give them the tightness and antimicrobial properties.

A known method of manufacturing a vascular prosthesis, comprising impregnation tube of flexible porous material composition on the basis of gelatin containing the pre-modified gelatin with a certain amount of amino groups is less than in the original substance, the processing of the impregnated tube to form cross-links between amino groups. Modification of gelatin are encouraged to interact with the anhydride or chloride of polycarboxylic acid (US No. 4747848, Vascular grafts). In the composition of the coatings obtained in this way, there are no active substances can make the surface resistant thromboresistant effect. The technology process is multi-stage and complex to implement.

There is a method of closing have a vascular prosthesis gelatin, crosslinked with diisocyanate (US No. 4784659, Vessel and prosthesis impregnated with diisocyanate crosslinked gelatin). The method includes preparation of a composition based on gelatin, modified polycarboxylic acid, applying the composition on a textile basis of the restoration and stabilization of the coating by treatment with a diisocyanate. Used in the method of connection class diisocyante the s are highly toxic substances. On the stage of stabilization of the coating in addition to the main reaction is the formation of intermolecular bonds in the gelatinous matrix - flows uncontrolled process of formation of the products of the side reactions of diisocyanates with other components of the composition. The resulting material is difficult to completely remove from the scope of coverage, and their release into the bloodstream is undesirable due to unpredictable behavior in the body.

Known prosthesis made of polytetrafluoroethylene (PTFE=ftorlona) (US No. 5716395, 1998, Prosthetic vascular graft), which provides for the possibility of impregnation material of the prosthesis antibiotics.

There is a method of coating antibiotics vascular prostheses and other implants (US No. 4442133, 1984, Antibiotic bonding of vascular prostheses and other implants), based on the pre-treatment of the material of the prosthesis tridodetsilamin chloride to give him cationic properties and subsequent adsorption on the material of antibiotics with anionic properties. This method of treatment improves binding substances with anionic properties, including some antibiotics, through ionic bonds. However, the mechanical properties of prosthetic material (water resistant) remain unchanged.

The known method, machining of implants, of textile materials composition containing acetylsalicylic acid, heparin and Latin, and execution of intermolecular crosslinking of gelatin aqueous solution of glutaraldehyde followed by treatment with a solution of glycerol in the mixture of water with ethanol (RU # 2135214). The method adopted for the prototype.

Analysis of the known methods of processing of textiles showed that there is no way that provides products at the same time waterproof and antimicrobial properties.

The technical result achieved by the invention, is to make the products for cardiovascular surgery of textile materials waterproof and antimicrobial properties.

The claimed technical result is achieved in a method of treatment of textile products for cardiovascular surgery, including treatment product composition containing gelatin, and intermolecular crosslinking of gelatin aqueous solution of glutaric aldehyde, in which the composition for treatment of the product additionally contains glycerin, at least one antibiotic and 0.9% sodium chloride solution in the following ratio of components (wt.%):

gelatin5,0-7,5
glycerin20,0-30,0
antibioticeffective amounts of the Sabbath.
0.9% solution of sodium chloridethe rest of it.

It is advisable that the composition contained at least one antibiotic from a number of Cefotaxime, ciprofloxacin, doxycycline, oxacillin. This list is not exhaustive and may include other antibiotics.

It is also advisable that the composition additionally contains metronidazole in the amount of 4.0-10.0 wt.%.

Now that the composition containing Cefotaxime and metronidazole in the amounts (wt.%):

Cefotaxime4,0-10,0;
metronidazole4,0-10,0.

It is also suitable for textile pre-treating an aqueous solution of glutaraldehyde at a concentration of 0.5-0.75% to achieve a uniform impregnation of the base material, and then to perform processing composition.

Glycerin is introduced into the composition by contacting the gelatin gives a vascular prosthesis plasticity, i.e. acts as a plasticizer, due to the fact that it is able to retain moisture and gives the final product waterproof properties, resistance to acids and insolubility in acetone and organic solvents.

Included is e in the composition for impregnation of the textile basis of the product of antibiotics, possessing antibacterial activity against aerobic and anaerobic gram-positive and gram-negative microorganisms improves the efficiency of binding of antibiotics in the composition of the gel and the preservation of their antibacterial properties for a long time.

This is due to more efficient binding of antibiotics to the expansion of the gelatinous matrix, i.e. its ability to keep antibiotics in its composition. The binding of antibiotics and non-covalent caused mainly by the formation of hydrogen and ionic bonds with the functional groups of the gelatin matrix.

The formation of hydrogen bonds in this case takes place directly during the formation of the matrix simultaneously with the process of crosslinking of gelatin polypeptides due to covalent binding of the aldehyde groups of glutaraldehyde and available amino groups in the structure of the polypeptides. In addition, the presence of free amino groups in the molecule of the antibiotic (Cefotaxime), part of the molecules of the antibiotic may be contacted with the matrix (and each other) covalent bonds due to the interaction with the molecules of glutaraldehyde.

The content in the composition Cefotaxime and additionally metronidazole in the amounts (wt.%):

Cefotaxime4,0-10,0
metronidazole4,0-10,0

provides a high antibacterial effect of the product, as in the proposed method the introduction of antibiotics in the floor metronidazole potentiates the action of Cefotaxime.

All components of the composition are in optimal concentrations.

The gelatin content lower than 5.0 wt.% does not provide an effective closing of the pores of the textile material, above 7.5 wt.% - does the composition-low-tech because of the high viscosity.

The use of glycerin solution with a concentration of less than 20.0 wt.% does not provide the required elasticity of the coating, the above-30.0 wt.% leads to the deterioration of its mechanical strength.

The number and type of antibiotic is selected depending on the appropriate effect provide antibacterial action.

0.9% sodium chloride else.

Pre-treatment of textile fundamentals aqueous solution of glutaraldehyde at a concentration of 0.5-0.75% to achieve a uniform impregnation of the material minimizes the number of free aldehyde groups, not contacting gelatine.

The concentration of glutaraldehyde below 0.5% does not provide the necessary degree of crosslinking of gelatin; higher than 0.75% - degrades mechanical about the ability of the coating.

The method is carried out, for example, as follows.

The composition is prepared from gelatin, glycerin, antibiotic and 0.9% solution of sodium chloride in predetermined concentrations with constant stirring, using an electric mixer for 5-7 minutes (this is the minimum time required to obtain homogeneity) to obtain a homogeneous mass, and then kept in the refrigerator during the day (this is the minimum time for which there is the maximum swelling of gelatin) at a temperature of +40 - +50C (the minimum temperature at which there is swelling of gelatin) to the swelling of gelatin.

Processing products, as well as its drying produce in the stretched condition to ensure uniform application of chemical solutions.

Textile product, such as a vascular prosthesis, immersed and soaked in 0.5-to 0.75% solution of glutaraldehyde for 2-3 minutes to achieve a uniform impregnation of the base material.

The solution with the swollen gelatin is heated on a water bath at a temperature of +40 to +55C (this temperature is optimal, since at temperatures below 40C the gelatin dissolves, above 55C is prone to hydrolysis) and continuously stirred with an electric stirrer.

In the heated solution is dipped soaked in glutaric the aldehyde vascular prosthesis for 2-5 min (this BP is me is the best, as with exposure less than 2 minutes, the coating is very thin and not all the pores are closed, when the exposure more than 5 minutes, the coating layer is very thick and uneven). The prosthesis is impregnated is dried over night at room temperature.

Prosthesis with such impregnation on the stand withstands pressure up to 300 mmHg, which demonstrates its integrity.

Evaluation of antimicrobial properties of the studied samples was conducted to demonstrate the presence of the drug in the prosthetic material or liquid in which the material was up to 3 days.

Example 1. Textile based vascular prosthesis made of the ftorlona-Dacron and represents a tube with a diameter of 10 mm, was kept for 2-3 minutes in a 0.5%solution of glutaraldehyde with the purpose of wetting, as evidenced by the absence of visible air bubbles on the surface of porous textile material. Then put in the stretched condition in a pre-prepared (for 24 hours before use) and heated to a temperature of +45 - +50C the composition of the following composition:

Gelatin - 5%

Glycerin - 25%

Cefotaxime - 10%

Metronidazole - 10%

0,9%isotonic (physiological solution of sodium chloride NaCl - 50%.

Stay textile fundamentals, moistened with glutaraldehyde in the composition was 300 seconds (5 mi the ut).

Impregnated with the composition of the textile material was dried for 24 hours at room temperature, and then carried out hydraulic test stand, allowing you to measure the pressure that may be applied to the investigated material and will not result in leakage of fluid from the pre-processed as described vessel. The maximum hydrostatic pressure at which the processed material maintains the waterproof properties during hydraulic tests, amounted to 300 mm Hg

Mechanical properties (elasticity and resistance to stretching) of the material obtained meet the requirements for materials of vascular prostheses.

Antimicrobial properties of the obtained material (prosthesis) is estimated after sterilization by ozone treatment on the sizes of zones of inhibition of growth of microorganisms (the distance from the edge of the object to the border of the zone of growth of the microorganism)measured after 24 h of growth for the following objects:

- fragments of the products prior to incubation in physiological solution, and after 1-2 - and 3-day incubation;

discs of filter paper soaked in a saline solution containing antibiotics, diffundiruyushchii during incubation of prosthetic material (0-3 days).

The results of the study of antimicrobial properties fragmento the treated material and disks of filter paper, saturated saline solution, in which from 0 to 3 days incubated material of the prosthesis (with change of medium every 24 hours)are presented in table 1.

Table 1
SampleA solution of (disk)
the zone of inhibition of growth of a microorganism after 24 hours of incubation (mm)
The duration of incubation (days)01230123
S. aureus 21025158001240
S. epidermidis2313600103 0
E. coli 439105200520
P. aeruginosa 2592363100310
Bacteroides spp.105200310
Fusobacterium spp.94200310
Peptostreptococcus spp.9530021 0

Thus, the preservation of the antimicrobial properties of the material and the transition components in the environment surrounding the material, not less than 48 hours.

Example 2. Processing and analysis of the properties of the material was carried out analogously to example 1.

When processing used the composition of the following composition:

Gelatin - 7%

Glycerin - 25%

Cefotaxime - 10%

Metronidazole - 4%

0,9%isotonic (physiological solution of sodium chloride NaCl - 54%.

Antimicrobial properties of the obtained material was investigated and evaluated by the same method as in example 1. The results of the study are presented in table 2.

Table 2
SampleA solution of (disk)
the zone of inhibition of growth of a microorganism after 24 hours of incubation (mm)
The duration of incubation (days)01230123
S. aureus 210 25168001450
S. epidermidis2313600940
E. coli 439116200630
P. aeruginosa 2592374100320
Bacteroides spp.84100210
Fusobacterium spp. 63200210
Peptostreptococcus spp.73200100

Thus, the preservation of the antimicrobial properties of the material and the transition components in the environment surrounding the material, not less than 48 hours.

Example 3. Processing and analysis of the properties of the material was carried out analogously to example 1.

When processing used the composition of the following composition:

Gelatin - 5%

Glycerin - 25%

Cefotaxime - 5%

Metronidazole - 5%

0,9%isotonic (physiological solution of sodium chloride NaCl - 60%.

Antimicrobial properties of the obtained material was investigated and evaluated by the same method as in example 1. The results of the study are presented in table 3.

Table 3
SampleR is the target (disk)
the zone of inhibition of growth of a microorganism after 24 hours of incubation (mm)
The duration of incubation (days)01230123
S. aureus 210130,370,240,10090,240,20
S. epidermidis120,560,230,10070,540,30
E. coli 43950,130,110,10040,220,10
P. aeruginosa 2592330,1 20,210,20020,120,20
Bacteroides spp.50,130,110,10010,110,20
Fusobacterium spp.50,220,110,20020,210,30
Peptostreptococcus spp.40,130,110,10010,100

Thus, the preservation of the antimicrobial properties of the material and the transition components in the environment surrounding the material, not less than 48 hours.

Example 4. Processing and analysis of the properties of the material was carried out analogously to example 1.

When processing used the composition is of the following composition:

Gelatin - 7,5%

Glycerin - 20%

Cefotaxime - 5%

Metronidazole - 5%

0,9%isotonic (physiological solution of sodium chloride NaCl - 62,5%.

Antimicrobial properties of the obtained material was investigated and evaluated by the same method as in example 1. The results of the study are presented in table 4.

Table 4
SampleA solution of (disk)
the zone of inhibition of growth of a microorganism after 24 hours of incubation (mm)
The duration of incubation (days)01230123
S. aureus 210140,180,350,100100,340,20
S. epidermidis130,3 60,240,20080,330,20
E. coli 43960,140,120,10030,110,10
P. aeruginosa 2592330,220,110,10020,120,10
Bacteroides spp.60,140,110,20010,210,10
Fusobacterium spp.40,220,110,100 30,110,20
Peptostreptococcus spp.40,220,210,10010,100

Thus, the preservation of the antimicrobial properties of the material and the transition components in the environment surrounding the material, not less than 48 hours.

Example 5. Processing and analysis of the properties of the material was carried out analogously to example 1.

When processing used the composition of the following composition:

Gelatin - 6%

Glycerin - 25%

Cefotaxime - 10%

0,9%isotonic (physiological solution of sodium chloride NaCl - 59%.

Antimicrobial properties of the obtained material was investigated and evaluated by the same method as in example 1. The results of the study are presented in table 5.

0
Table 5
SampleA solution of (disk)
the zone of inhibition of growth of a microorganism after 24 hours of incubation (mm)
The duration of incubation (days)01230123
S.aureus 21023125001050
S. epidermidis2211400940
E. coli 43995200430
P. aeruginosa 259234210021
Bacteroides spp.00000000
Fusobacterium spp.00000000
Peptostreptococcus spp.00000000

Thus, the preservation of the antimicrobial properties of the material and the transition components in the environment surrounding the material, not less than 48 hours.

Example 6. Processing and analysis of the properties of the material was carried out analogously to example 1.

When processing used the composition of the following composition:

Gelatin - 5,5%

Glycerin - 20,5%

Ciprofloxacin - 10%

0,9%isotonic (physiological solution of sodium chloride NaCl - 64%.

Antimicrobial properties of the obtained material was investigated and evaluated by the same method as in example 1. The results of the study are presented in table 6.

Table 6
SampleA solution of (disk)
the zone of inhibition of growth of a microorganism after 24 hours of incubation (mm)
The duration of incubation (days)01230123
S. aureus 21021115001050
S. epidermidis168300630
E. coli 43910 5300520
P. aeruginosa 2592394200310
Bacteroides spp.00000000
Fusobacterium spp.00000000
Peptostreptococcus spp.00000000

Thus, the preservation of the antimicrobial properties of the material and lane the progress of the components in the environment, the surrounding material is not less than 48 hours.

Example 7. Processing and analysis of the properties of the material was carried out analogously to example 1.

When processing used the composition of the following composition:

Gelatin - 7,5%

Glycerin - 25%

Ciprofloxacin - 10%

0,9%isotonic (physiological solution of sodium chloride NaCl - 57.5 per cent.

Antimicrobial properties of the obtained material was investigated and evaluated by the same method as in example 1. The results of the study are presented in table 7.

Table 7
SampleA solution of (disk)
the zone of inhibition of growth of a microorganism after 24 hours of incubation (mm)
The duration of incubation (days)01230123
S. aureus 210201040 0940
S. epidermidis179500740
E. coli 439104200410
P. aeruginosa 25923105200420
Bacteroides spp.00000000
Fusobacterium spp.0000 0000
Peptostreptococcus spp.00000000

Thus, the preservation of the antimicrobial properties of the material and the transition components in the environment surrounding the material, not less than 48 hours.

Example 8. Processing and analysis of the properties of the material was carried out analogously to example 1.

When processing used the composition of the following composition:

Gelatin - 5,5%

Glycerin - 25,5%

Doxycycline - 10%

0,9%isotonic (physiological solution of sodium chloride NaCl - 59%.

Antimicrobial properties of the obtained material was investigated and evaluated by the same method as in example 1. The results of the study are presented in table 8.

Table 8
SampleA solution of (disk)
the zone of inhibition of growth of a microorganism after 24 hours of incubation (mm)
The duration of incubation (days)01230123
S. aureus 210189400720
S. epidermidis2111500830
E. coli 43931000100
P. aeruginosa 259232100010 0
Bacteroides spp.31000100
Fusobacterium spp.21000100
Peptostreptococcus spp.31000100

Thus, the preservation of the antimicrobial properties of the material and the transition components in the environment surrounding the material, not less than 48 hours.

Example 9. Processing and analysis of the properties of the material was carried out analogously to example 1.

When processing used the composition of the following composition:

Gelatin - 7,5%

Glycerin - 20%

Doxycycline - 10%

0,9%isotonic (physiological solution of sodium chloride NaCl - 62,5%.

Antimicrobial properties of the obtained material was investigated and is valued by the same method as in example 1. The results of the study are presented in table 9.

Table 9
SampleA solution of (disk)
the zone of inhibition of growth of a microorganism after 24 hours of incubation (mm)
The duration of incubation (days)01230123
S. aureus 2101710500820
S. epidermidis2012610720
E. coli 4394 2100210
P. aeruginosa 2592321100110
Bacteroides spp.32100200
Fusobacterium spp.32100100
Peptostreptococcus spp.22000100

Thus, the preservation of the antimicrobial properties of the material and lane the progress of the components in the environment, the surrounding material is not less than 48 hours.

Example 10. Processing and analysis of the properties of the material was carried out analogously to example 1.

When processing used the composition of the following composition:

Gelatin - 5%

Glycerin - 25%

Oxacillin - 10%

0,9%isotonic (physiological solution of sodium chloride NaCl - 60%.

Antimicrobial properties of the obtained material was investigated and evaluated by the same method as in example 1. The results of the study are presented in table 10.

Table 10
SampleA solution of (disk)
the zone of inhibition of growth of a microorganism after 24 hours of incubation (mm)
The duration of incubation (days)01230123
S. aureus 21020940830
S. epidermidis187300520
E. coli 43931000100
P. aeruginosa 2592342100210
Bacteroides spp.00000000
Fusobacterium spp.0000000
Peptostreptococcus spp.00000000

Thus, the preservation of the antimicrobial properties of the material and the transition components in the environment surrounding the material, not less than 48 hours.

Example 11. Processing and analysis of the properties of the material was carried out analogously to example 1.

When processing used the composition of the following composition:

Gelatin - 7,5%

Glycerin - 20,5%

Oxacillin - 10%

0,9%isotonic (physiological solution of sodium chloride NaCl - 62%.

Antimicrobial properties of the obtained material was investigated and evaluated by the same method as in example 1. The results of the study are presented in table 11.

Table 11
SampleA solution of (disk)
the zone of inhibition of growth of a microorganism after 24 hours of incubation (mm)
The duration of incubation (days)01230123
S. aureus 2102111300840
S. epidermidis177300630
E. coli 43932100210
P. aeruginosa 259235310022 0
Bacteroides spp.00000000
Fusobacterium spp.00000000
Peptostreptococcus spp.00000000

Thus, the preservation of the antimicrobial properties of the material and the transition components in the environment surrounding the material, not less than 48 hours.

Thus, the gelatinous matrix obtained by the claimed method can be regarded not only as a sealing impregnation of textile basics products, but also as a means of delivery of the antibiotic directly to the site of surgical intervention. This will reduce chemotherapeutic burden on the patient in paleoposition the initial period, because delivery of the antibiotic is carried out not only by parenteral administration, but also in the composition of the material used for surgical intervention.

1. The method of processing textile products for cardiovascular surgery, including treatment product composition containing gelatin, and intermolecular crosslinking of gelatin aqueous solution of glutaric aldehyde, characterized in that the composition for treatment of the product additionally contains glycerin, at least one antibiotic and 0.9%sodium chloride solution in the following ratio, wt.%:

gelatin5,0-7,5
glycerin20,0-30,0
antibiotican effective amount
a 0.9%solution of sodium chloriderest

2. The method according to claim 1, characterized in that the quality of the antibiotic composition contains at least one antibiotic from a number of Cefotaxime, ciprofloxacin, doxycycline, oxacillin.

3. The method according to claim 1, characterized in that the composition additionally contains metronidazole in the amount of 4.0-10.0 wt.%.

4. The method according to claim 2 and 3, different is the present, the composition contains Cefotaxime and metronidazole in amounts, wt.%:

Cefotaxime4,0-10,0
metronidazole4,0-10,0

5. The method according to claim 1, wherein the pre textile base treated with an aqueous solution of glutaraldehyde at a concentration of 0.5-0.75% to achieve a uniform impregnation of the base material, and then treated with composition.



 

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83 cl, 1 dwg, 2 tbl, 25 ex

FIELD: medicine.

SUBSTANCE: offered is medical device adapted for local application or introduction in hollow tubes and containing therapeutic dose of N-{5-[4-(4-methylpiperazinomethyl) benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidinamine or its salt, crystal form with possible release thereof, its application for prevention or reduction of dysfunction caused by approach to vessels and related method of treatment (prevention). Particularly offered is method of restenosis treatment or prevention inpatients suffering from diabetes. It is detected that local introduction of M-{5-[4-(4-methylpiperazinomethyl) benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidinamine or its pharmaceutically acceptable salt or crystal form under declared method provides unexpectedly high stability of compound within 45 days compared to its activity value when introduced as free form.

EFFECT: provides high stability of compound.

5 cl, 7 ex

FIELD: chemistry.

SUBSTANCE: invention relates to N-substituted monomers and polymers used in medical devices. Disclosed is a polymer meant for use in implantable medical devices, which contains a plurality of monomer repeating units containing an N-substituted amide of formula (I) where each of X1 and X2 is independently selected from Br and I; each y1 and y2 is independently equal to zero or an integer ranging from 1 to 4, and R1 is selected from substituted or unsubstituted, saturated or unsaturated, straight or branched aliphatic groups containing up to 48 carbon atoms, substituted or unsubstituted aromatic groups containing up to 48 carbon atoms, and substituted or unsubstituted araliphatic groups containing up to 48 carbon atoms, wherein the aliphatic parts are straight or branched and saturated or unsaturated, wherein R1 contains 2-8 heteroatoms selected from O, S and N, where two of the heteroatoms form an amide group of the polymer backbone chain which is an N-substituted C1-C6 alkyl group. Corresponding monomers and versions of use of the disclosed polymer in medicine are also disclosed.

EFFECT: disclosed polymers are characterised by low melt viscosity and can be easily processed without decomposition.

24 cl, 8 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to antibacterial lenses, containing metals and methods of their obtaining. Method of obtaining antibacterial lens, containing metal salt, is characterised by a) stage of processing hardened lens with solution, containing salt precursor and b) processing of lens, obtained at stage a) with solution, containing metal-containing agent, where molar ratio of said metal-containing agent in its solution constitutes from 0.6 to 10.0.

EFFECT: invention ensures obtaining antibacterial lens with low content of opacity/Ag, which makes possible its long application with transparency, sufficient for user to be able to see through the lens clearly.

10 cl, 1 tbl, 1 dwg, 4 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to field of medicine, in particular, to ophthalmology. Group of inventions relate to antibacterial lenses, which contain metals, and methods of there production. Antibacterial lens which contains metal salt, obtained by method (versions), which includes stages: (a) processing hardened lens by solution, which contains metal-containing preparation and efficient quantity of acid substance, where pH of claimed solution constitutes from 2 to 5; and (b) processing of lens from (a) stage with solution, containing, basically containing or consisting of salt precursor and efficient quantity of acid substance, where pH of said solution constitutes from 2 to 5.

EFFECT: group of inventions ensures obtaining contact lenses, which contain antibacterial medications of constant composition.

19 cl, 2 dwg, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine. There are described medical implanted devices made of a polymer material and a separation agent wherein the device is a cast reservoir implant, while the separation agent has a molecular weight (M.w.) of min. 1000. The separation agent can be presented by a non-ionic surfactant, such as Bridge-35, polyoxyethylene (20) sorbitan trioleate, Tween 20, Tween 80, vitamin E TPGS, and a mixture of any two or more of them. The hydrated implants can have a surface area of approximately 500 mm2 or more.

EFFECT: used separation agents causes no undesired reactions with cartridge polymer and are safely introducible in a patient.

29 cl, 5 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, specifically to cardiovascular surgery and may be used for modification of synthetic implanted medical devices. What is described is a method for processing synthetic textile implanted medical devices involving coating the devices with hydrogel of natural biodegradable polymers wherein the natural biodegradable polymer is presented by polysaccharide chitosan or its derivatives (carboxymethykated sulphated chitosan) in a combination with polyester-poly-3-hydroxybutyrate. The coating is dried and transferred in the water-soluble state by thermal processing at 100C.

EFFECT: method for processing synthetic textile implanted blood contact medical devices enables providing the devices with a complex of the required properties: higher thromboresistance and antimicrobial action, zero surgical porosity and prolonged drug release.

3 cl, 1 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine. Described is membrane envelope of implanted dosing system, which is suitable for hypodermic application. Membrane envelope contains first half and second half, and both halves contain continuous locking edge and are made with possibility of connection to each other by means of lockable connection. Locking edges of halves contain, at least, one hollow and/or, at least, one projection, made as continuous or discontinuous, and membrane envelope is made with possibility of locking in such a way, that, at least, one projection and/or, at least, one hollow of second half became opposite to, at least, one hollow and/or, at least one projection of first half by means of locking connection.

EFFECT: membrane envelope is suitable for hypodermic application aimed at separation of active agent in constant quantity during increased time interval.

10 cl, 2 dwg, 1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to N-substituted monomers and polymers, methods of producing such monomers and polymers and methods for their use for different medical purposes, e.g., in medical devices. Disclosed is a polymer which contains a repeating unit of formula (I), where X1 and X2 are independently selected from Br and I; y1 and y2 are equal to zero or an integer from 1 to 4, A1 is selected from a group consisting of , , , and , R3 is selected from C1-C30 alkyl, and C1-C30 heteroalkyl, C5-C30 aryl, C6-C30 alkylaryl and C2-C30 heteroaryl; R4 is selected from H, C1-C30 alkyl and C1-C30 heteroalkyl; R1 is (A) or (B); Z is O or S; R5 and R6 are selected from -CH=CH-, -CHJ1-CHJ2- and -(CH2)a-; a equals zero or an integer from 1 to 8; J1 and J2 are independently selected from H, Br and I; Q is a group which contains 20 or more carbon atoms; Rx is selected from optionally substituted branched or straight C7-C30 alkyl and optionally substituted C6-C30 aryl; and Ry is selected from hydrogen, optionally substituted branched or straight C1-C30 alkyl and optionally substituted C6-C30 aryl. Also disclosed are versions of said polymer, methods of producing said polymers and a medical device containing the disclosed polymers. The medical device is preferably a stent.

EFFECT: disclosed polymer has improved physical and chemical properties and is suitable for use in implantable medical devices.

31 cl, 1 dwg, 2 tbl, 3 ex

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