Method for integrated treatment of acute thromboembolia of pulmonary artery
SUBSTANCE: invention refers to medicine, namely angiology, intensive care, cardiovascular surgery and phlebology, and may be used for integrated treatment of acute thromboembolia of pulmonary artery. That is ensured by prescribing anticoagulants, disaggregants, antibiotic therapy added by thrombolytic therapy by the oral introduction of the preparation Thrombovasim 0.02 mg/kg combined with deobliteration of pulmonary artery or pulmonary trunk by direct surgical thromboembolectomy in complete bypass with retrograde perfusion of pulmonary arteries. Treatment of acute thromboembolia is added by prescribing the preparation Vasaprostan* 60 mcg daily intravenously starting from the moment of diagnosing and up to 7 postoperative days.
EFFECT: method provides higher clinical effectiveness in the patients and preventing developing complications ensured by correction of main pathological links of developing complications of acute thromboembolia of pulmonary artery.
The invention relates to medicine, namely, angiology and intensive care, cardiovascular surgery and phlebology, and can be used for complex treatment of acute pulmonary embolism (PE).
Statistics in recent years both in Russia and abroad shows that a civilized society is losing hundreds of thousands of people due to development of acute pulmonary embolism: a case fatality rate is 30 to 45%, and an increase in the frequency of pulmonary embolism is becoming threatening [Nekrasov Û.F., H. beavers, Osipov A.M., Antonov S.A. Acute pulmonary embolism. Methodological manual for doctors. SPb., 1996. - 25 S.].
Known methods of treatment of acute pulmonary embolism (PE), including thrombolytic therapy, invasive (non-surgical) methods, such as catheter embolectomy, and surgical embolectomy (with or without artificial circulation (IR).
The best results of treatment of massive pulmonary embolism obtained using surgical deobliteration pulmonary artery by direct embolectomy [Aklog L, Williams CS, Byrne JG, Goldhaber SZ. Acute pulmonary embolectomy; a contemporary approach. Circulation 2002; 105:1416-1419. Yalamanchili K, Fleisher AG, Lehrman SG, Axelrod HI, Lafaro RJ, Sarabu MR et al. Open pulmonary embolectomy for treatment of major pulmonary embolism. Ann Thorac Surg 2004; 77:819-823. Dauphine C, Omari B. Pulmonary embolectomy for acute massive pulmonary embolism. Ann Thorac Surg 2005; 79:1240-1244. Kucher N, Goldhaber SZ. Management of massive pulmonary embolism. Circulation 2005; 112:28-32. Leacche M, Uic D, Goldhaber SZ, Rawn JD, Aranki SF, Couper GS, et al. Modern surgical treatment of massive pulmonary embolism: results in 47 consecutive patients after rapid diagnosis and aggressive surgical approach. J Thorac Cardiovasc Surg 2005; 129: 1018-1023].
The lack of direct surgical embolectomy is [Albertine PHD, Wiener-Kronish JP, K. Koike engineering Germany, N.C. Staub Quantification of damage by air emboli to the lung microvessels in anesthetized sheep. J Appl Physiol 1984; 57:1360-1368. Wang D, Li MH, Hsu K, Shen CY, Chen HI, Lin YC. Air embolism-induced lung injury in isolated rat lungs. J Appl Physiol 1992; 72:1235-42. Huang KL, Lin YC. Activation of complement and neutrophils increases vascular permeability during air embolism. Aviat Space Environ Med 1997; 68:300-5. Kuhn M, Fitting JW, Leuenberger P. Acute pulmonary edema caused by venous air embolism after removal of a subclavian catheter. Chest 1987; 92:364-365. Fitchet A, Fitzpatrick AP. Central venous air embolism causing pulmonary oedema mimicking left ventricular failure. BMJ 1998; 316:604-606. Boer WH, Hene RJ. Lethal air embolism following removal of a double lumen jugular vein catheter. Nephrol Dial Transplant 1999; 14:1850-1852. Kapoor T, Gutierrez G. Air embolism as a cause of the systemic inflammatory response syndrome: a case report. Crit Care 2003; 7:98-100]:
1. the inability of embolectomy out of small branches LA,
2. the impossibility of simultaneous surgical intervention and systemic thrombolysis,
3. experimental and clinical data indicate the development of air embolism LA arising from thromboembolectomy that induces the release of endothelial cytokines, which in turn cause damage to the microvascular LA and pulmonary parenchyma, leading to complications and death.
The aim of the invention is to increase the effectiveness of treatment Bo is lnyh with pulmonary embolism (PE) and prevention of complications.
This goal is achieved through improvement microsimulating channel of the lung parenchyma by assigning intravenous drugs prostaglandin series, for example Vazaprostan®a daily dose of 60 mcg.
The introduction of the drug carried out intravenously since the diagnosis of pulmonary embolism in the preoperative period and up to 7 days in the postoperative period.
The drug Vazaprostan®is similar to the natural PgE1has vasodilator (at the level of arterioles, precapillary sphincter muscle of the arteries), antiplatelet and angioprotective action. Improves microcirculation and peripheral circulation, promotes the opening of collateral vessels. Improves blood rheology, increasing the elasticity of red blood cells and reducing the adhesion/aggregation of platelets. Possesses fibrinolytic effect. Affects the metabolism and increases utilization of glucose and oxygen, inhibits the release of free radicals and lysosomal enzymes from granulocytes and macrophages, stimulates protein synthesis, has a favorable effect on lipid metabolism (inhibiting the synthesis of cholesterol and reducing the concentration of LDL), inhibits the proliferation of smooth muscle cells. These known effects of the drug Vazaprostan®about navyvet its application in complex treatment of pulmonary embolism.
The method involves surgical benefits under endotracheal anesthesia in order to restore blood flow in the pulmonary artery is a direct open thromboembolectomy in conditions of artificial blood circulation and conduct retrograde perfusion LA. The implementation of the operational allowance is as follows.
Access to LA to produce an accepted way by performing a sternotomy.
Retrograde perfusion LA is used in conditions normothermal RJ with biovalley sinularia. Arterial line from the heart-lung machine is connected with a Y-shaped connector. One branch attached arterial cannula (which subsequently kanyoro the ascending aorta), the other is synthetic, perestou clip tube size 20 F, which kanyoro left atrium (through the right upper pulmonary vein, perestou a ligature). After the beginning of the IR pereginus the ascending aorta and perform cardioplegia. A longitudinal incision to expose the pulmonary trunk (distal to the valve of the pulmonary artery), the next section continues on the right and left main branches of LA. Thrombotic mass removed using surgical clamps and suction. Produce a revision of the right atrium and ventricle, remove all visible blood clots. Then (while LA is still open) remove the clamps on the left cannula and left preserv is filled with blood. After about 1 minute the blood begins to flow from the LA retrograde. Against this background, produce inflating lung ventilator for the most complete removal of thrombotic masses and air bubbles from distal branches of the LA. Clots and air bubbles aspiritual from LA. Then anteriormente hole is sutured, "left" cannula disconnect from the arterial line (Y-shaped connector) and used as drainage of the left atrium. Remove the clamp from the aorta and IR finish the generally accepted method.
To achieve complete removal of thrombotic masses of distal branches of the LA during thromboembolectomy patient in complex preoperative preparation include the appointment of a thrombolytic drug "Trombulak®" at a dosage of 0.02 mg/kg of the Drug Trombulak®" has the Thrombolytic effect associated with direct effects on fibrin and cellular mass of thrombus, anti-inflammatory and cytoprotective properties (patent RF №2213557), which justifies its use in complex therapy of pulmonary embolism.
Trombulak®increases fibrinolytic activity of the blood, providing a direct fibrinolytic action. The drug has a thrombolytic effect, the mechanism of which is associated with the direct destruction of the threads of fibrin, the arr is based on the basic framework of a blood clot. Trombulak®not reduces the level of fibrinogen, platelets, does not affect the coagulation time and duration of bleeding. Reduces the intensity of reperfusion damage, because it has anti-inflammatory and cytoprotective effect. Trombulak®not hydrolyzes native tissue proteins. The use of Thrombopathia®not contraindicated in the run-up to the operational manual and in the postoperative period.
In the complex treatment of pulmonary embolism, the technique is applied in 7 patients. The use of this method has greatly improved the results of complex treatment of pulmonary embolism.
The use of the proposed method in clinical practice revealed the following significant advantages over known methods of treatment of pulmonary embolism.
The combination of open thromboembolectomy and retrograde perfusion allows you to release all the arterial tree from thromboembolic masses.
Used in the treatment of drug Trombulak reduces the probability of rethrombosis in the field of surgery and repeated episodes of pulmonary embolism due to the impact on the primary focus of thromboembolism.
The method allows you to return to the workforce and to improve the quality of life of patients, as well as to enlarge the pool of patients previously midrange is remaining hopeless in the outcome of the surgical treatment.
The method of complex treatment of acute pulmonary embolism, including the appointment of anticoagulants, antiplatelet, antibiotic therapy and thrombolytic therapy, characterized in that thrombolytic therapy is carried out by introduction of oral thrombolytic drug "Trombulak" at a dosage of 0.02 mg/kg and complement deobliteration pulmonary artery or pulmonary trunk by direct surgical thromboembolectomy in extracorporeal circulation with conducting retrograde perfusion of the pulmonary arteries, complementing the comprehensive treatment of pulmonary embolism-drug Vazaprostan®a daily dose of 60 µg intravenously, starting from the moment of diagnosis and finishing the course of treatment on day 7 post-operative period.
FIELD: medicine, pharmaceutics.
SUBSTANCE: what is presented is the new chemical compound - a 3-(2,2,2-trimethylhydrazinium)propionate derivative - 3-(2,2,2-trimethylhydrazinium)potassium propionate glycinate, (CH3)3N+NHCH2CH2COOKRCOO-, wherein exhibiting endothelioprotective activity. The presented derivative can find application in medicine in the integrated treatment for endothelial dysfunction correction in cardiovascular diseases.
EFFECT: enhanced endothelioprotective properties as compared with previously known mildronat due to the introduction of new functional group showing the most manifested antioxidant properties.
SUBSTANCE: there are conducted crossectomy, direct and/or indirect thrombectomy, ligation of inadequate perforating veins and varicose flows of subcutaneous vein stems. A pathological venous bed is eliminated by endovasal laser coagulation (EVLC) of the inadequate subcutaneous vein stems. The surgical procedure is performed under tumescent anaesthesia of the EVLC region by physiologic saline cooled to 6-7°C at ozone concentration 4-5 mcg/ml. It is assisted by continuous ultrasonic navigation. The EVLC region involved in varicothrombophlebitis and the incisional wound are processed by argon-plasma flow followed by elastic compression of the operated extremity.
EFFECT: method extends the range of product for treating acute varicothrombophlebitis of the lower extremities.
SUBSTANCE: gestosis model in Wistar rats is reproduced by the daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg for 14th to 20th day of pregnancy. The simulated pathology is corrected by the subcutaneous introduction of recombinant erythropoietin 50 IU/kg on the 7th, 10th, 13th, 16th, 19th day of pregnancy.
EFFECT: method provides evident placental microcirculation correction.
SUBSTANCE: invention refers to medicine, namely surgery, and may be used for treating acute thrombophlebitis of lower extremities. That is ensured by the subcutaneous introduction of a mixture containing lydase, heparin and novocaine within a first web space of a foot with underlying conventional therapy. It is added with the introduction of a medicated mixture containint 0.25% novocaine 30 ml; lydase 64 standard units; 1% emoxipin 1 ml; dexamethasone 2 ml; fraxiparine 0.6 ml (11400 IU), sodium adenoside-triphosphate 1 ml; cefotaxime 1 mg; nicotinic acid 2 ml into a dorsal and plantar direction, to a medial and lateral side from the Achilles tendon, as well as around a vein involvement wherein a pathological process of acute thrombophlebitis develops, and into interspinous ligaments of the L2-3-L3-4 lumbar vertebrae. The therapeutic sessions are performed every second day within a therapeutic course of 5-10 procedures to arrest the inflammatory process completely. The therapeutic course is applied once more in 2-3 months.
EFFECT: method provides higher clinical effectiveness, reduced risk of threatening complications and limited progression of the disease due to pathogenetically proved action of surface and deep lymphatic networks of the lower extremities with expected activation of the transcapillary exchange.
SUBSTANCE: invention refers to medicine, namely restorative medicine and angiology, and may be used for treating the patients with chronic lymphovenous insufficiency of lower extremities. That is ensured by applying a homogenised gel of brown algae at temperature 28-30°C and wrapping the extremities with non-woven tissues (drapes). That is followed by immediate alternative pneumatic compression by the Lympha-E apparatus on the lower extremities. That involves the ascending wave pressure memorising mode, the II operation mode at pressure 60-90 mm Hg for 40-60 minutes. The procedures are daily, 5 times a week with a pause of 2 days. The therapeutic course is 10-20 procedures.
EFFECT: method provides higher clinical effectiveness at all the stages in any length of the disease including due to additional stimulation of the lymphodrainage function, improved microcirculation, peripheral haemodynamics, improved plasma-coagulation phase of haemostasis, improved tissue trophism.
SUBSTANCE: invention refers to medicine, namely surgery, and may be used for sclerosing therapy of hemorrhoid. That is ensured by the sclerosing therapy by introducing a detergent into a hemorrhoid. It is immediately followed by a vibroacoustic session above the sclerosed hemorrhoids. The vibroacoustic session is performed in the frequency range of 0.26 kHz and 0.55 kHz alternatively 30 sec each for 3 minutes.
EFFECT: method provides higher clinical effectiveness ensured by faster relief of the perianal inflammation manifestations, reduced complications and recurrences after a single action of sclerosants.
SUBSTANCE: group of inventions refers to medicine. Group of inventions involves the use of lisuride or terguride or their enantiomers, or their salts or hydrates for treating and preventing pulmonary arterial hypertension, endogenic or exogenic induced glomerular sclerosis, as well as secondary Reynaud's syndrome; the use of lisuride or terguride or their enantiomers, or their salts or hydrates for treating and preventing said diseases; a pharmaceutical composition for treating and preventing said diseases containing a compound specified in a group consisting of lisuride, terguride, their enantiomers, as well as their salts or hydrates, together with a pharmaceutically compatible carriers, excipients and/or solvents.
EFFECT: group of inventions provides higher therapeutic and preventive effectiveness.
6 cl, 10 ex, 3 dwg
SUBSTANCE: method involves simulating gestosis in Wistar rats by the daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg for 14th to 20th day of pregnancy. The simulated pathology is corrected by the subcutaneous introduction of recombinant erythropoietin 50 IU/kg on the 7th, 10th, 13th, 16th, 19th day of pregnancy.
EFFECT: method provides correction of systemic endothelial dysfunction accompanying gestosis in the specific experimental environment.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to chemical-pharmaceutical industry and represents medication for treatment of hemorrhoids, proctitis and other inflammatory proctological diseases in form of rectal suppository, characterised by the fact that it contains as active substances Juglanex and Tycveolum, as auxiliary substances contains polyethylene glycol 1500 and emulsifier T2, components in medication are in specified ratio in grams per 1 suppository, with weight 2.6 g.
EFFECT: invention ensures anti-inflammatory and regenerating action, and possesses good penetrating ability.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention concerns chemical-pharmaceutical industry, namely to production biologically active medications based on vegetal raw materials. The dihydroquercetin-based composition possessing capillary-protective activity additionally contains basic magnesium carbonate at a weight ratio of 4:1 - 1:4 accordingly. The composition production method is as follows: dihydroquercetin and basic magnesium carbonate are mixed at a weight ratio of 4:1 - 1:4 accordingly; then the mixture undergoes mechanical treatment by way of impact-and-abrasive effects until formation of agglomerates of milled particles sized 1 - 70 microns. The compositions based on dihydroquercetin and basic magnesium carbonate produced icy the method proposed is noted for improved solubility of dihydroquercetin in water solutions, accelerates microvascular circulation thereby ensuring capillary therapeutic action.
EFFECT: during the produced composition hydration accelerated release of dihydroquercetin into the water solution occurs.
2 cl, 5 tbl, 3 dwg
SUBSTANCE: invention relates to medicine, namely, to oncology, and can be used in complex treatment of metastases in liver, in particular of large intestine cancer. For this purpose, performed is sampling of 200 ml of blood with its further centrifuging and separation of autoleukomass. 5 ml of autoleukomass and chemical preparations are placed into the first vial, the remaining formed elements of blood, plasma and chemical preparations are placed into the second vial. Vials are incubated separately for 40 minutes at 37°C. After that transcutaneous radio-frequency thermal ablation of metastases into liver is performed under ultrasound control. When thermal ablation is finished, incubated autoleukomass with chemical preparations from the first vial is introduced into the bed of metastasis subjected to thermal destruction by means of infusion pump in electrosurgical device. Simultaneously incubated formed elements of blood, plasma with chemical preparations from the second vial are introduced intravenously by drop infusion.
EFFECT: method makes it possible to reduce frequency of tumour progressing and increase survival of patients due to combination of surgery, local intra-tissue chemical therapy and autohemochemotherapy.
SUBSTANCE: invention refers to medicine, namely oncology, and may be used in treating patients with generalised prostate cancer. That is ensured by androgen blockade. Three days later, AMACR, bcl-2, bmp-7 protein levels are measured by laser disorption time-of-flight mass spectrometry. It is followed by the intravenous introduction of the mixture of autoblood 150 ml and docetaxel 80 mg incubated at 37°C for 40 minutes. In 21 days, the same amount of said mixture is introduced to total amount of docetaxel 400 mg. Five introductions of the chemopreparations are prescribed. The protein levels are measured once again. Decreasing the levels in 3-5 times testifies to the clinical effectiveness, while decreasing the protein levels less than in 3 times shows no therapeutic effect.
EFFECT: method provides the adequate assessment of the clinical effectiveness in the given pathology consistent with an adequate approach.
SUBSTANCE: invention refers to medicine, specifically cardiosurgery, and may be used in open heart surgery. For this purpose, 2 days before the surgery the intensity of an anaerobic threshold is determined by inhaling a hypoxic gas mixture during ergospirometry. The breathing process is accompanied with stepped decrease of the oxygen content in the mixture by 2% to achieve oxygen consumption and carbon dioxide release at each stage of stabilisation. If the intensity of the anaerobic threshold is more than 14% of oxygen, a degree of patient's cardiorespiratory adaptation is considered to be low, and autoblood is sampled in the amount of max. 5% of circulating blood. If the intensity of the anaerobic threshold is 10-14% of oxygen, a degree of patient's cardiorespiratory adaptation is considered to be moderate, and autoblood is sampled in the amount of max. 7% of circulating blood. If the intensity of the anaerobic threshold is less than 10% of oxygen, a degree of patient's cardiorespiratory adaptation is considered to be high, and autoblood is sampled in the amount of max. 10% of circulating blood.
EFFECT: method enables the effective complex preparation of the patient for the open heart surgeries, the adequate hemotransfusion therapy ensured by the precise determination of patient's adaptation to hypoxia.
SUBSTANCE: group of inventions refers to medicine. A cartridge unit comprises a rigid body, a first flexible tube with its first and second ends attached to the rigid body forming a loop part wherein there is a hose pump rotor of a medical device with the first end of the first flexible tube connected to an outlet of a first chamber, a second flexible tube with its first end connected to an inlet of a first chamber, a third flexible tube with its first end attached to the rigid body and being in a liquid connection with a second end of the first tube. A rigid tubular part comprises first and second terminal connector and an intermediate portion passing between the connectors contacting with a fluid medium flowing through the intermediate portion for the purpose of measuring a fluid medium parameter. The first terminal connector is attached to one element chosen from a group consisting of: the second end of the second flexible tube, and the second end of the third flexible tube. The connectors have an external prismatic surface having radially projecting element coupled with a connective socket on a holder of the apparatus. There are disclosed versions of the cartridge unit, the rigid tubular part and a medical apparatus applying them.
EFFECT: reliable and reproducible measurement of blood parameters.
30 cl, 20 dwg
SUBSTANCE: invention relates to efferent medicine and can be used in case of necessity of extracorporal blood purification in patients with purulent-septic conditions. For this purpose perfusion of blood through column with sorbent is performed. As sorbent Strosorb 414, or stirosorb 514, or Stirosorb 516 is used.
EFFECT: method makes it possible to increase efficiency of said pathology treatment due to selection of specified sorbents, which ensure binding of not only excessive number of endogenic mediators inducing development of pathophysiological disorders, resulting in development of organ and poly-organ failure, but also exogenic trigger and mediator inflammation factors, such as lipopolysaccharides and colony-forming cells.
2 cl, 2 tbl, 5 dwg
SUBSTANCE: invention relates to medicine, namely to coloproctology and deals with treatment of pilonidal cyst. Method includes excision of pilonidal cyst, bringing wound edges to wound bottom and partial suturing of wound with single "П"-shaped sutures without tension, carrying out antibiotic therapy. Before bringing wound edges to wound bottom on its lateral surface from the side of subcutaneous adipose cellular tissue made are 0.5 cm deep linear cuts along entire wound length at the distance 0.5 cm from the skin surface. At the distance 1.0-1.5 cm from post-operative wound edges at the level of wound bottom symmetrically from two sides installed are polychlorvinyl tubes equal in length to the wound length, with holes on the lateral surface, located in each 2 cm. In order to carry out immunotherapy, patient's blood is sampled, its cell masses are separated by centrifugation. Erythrocyte mass is returned to patient. Remaining cell mass is cultivated with 500000 U of interleukin-2 for 60 minutes at temperature 37°C, centrifuged with separation of supernatant fluid. Supernatant fluid, which contains complex of autologous cytokines, is introduced through tubes in volume 5 ml per each 2 cm of wound length on the first and third day after operation.
EFFECT: method ensures adequate immune sanitation of post-operative wound area, reducing risk of formation of cavities of wound edges and necrosis of wound edges.
2 cl, 3 dwg, 1 ex
SUBSTANCE: method includes preparation of platelets concentrates (PC) and the irradiation with ultraviolet radiation with the wavelength from 200 nm to 280 nm (UV-C radiation) with radiation energy in the range from 0.01 to 2 J/cm2. Every dose of PC is contained in flexible, UV-permeable flat package for irradiation with the volume up to 5000 ml, filled by less than 30% of maximal capacity. The package during irradiation is moved by the way of shaking, rocking, rotating, so that content is circulating and during circulation the zones with variable thickness of layers is formed. Additionally the irradiation with UV-B radiation with radiation energy in the range from 0.3 to 5 J/cm2 is performed. The plasma content in PC is more than 20% w/w.
EFFECT: pathogenic microbes and leucocytes deactivation while the platelet function remains unaltered.
25 cl, 8 tbl, 8 ex
SUBSTANCE: invention relates to medicine, namely to oncology and can be used in treatment of soft tissue sarcomas as one of complex treatment components. For this purpose sampling of 400 ml of blood into vial with hemopreservative is carried out with its further centrifugation at 1500 rotations per minute during 30 minutes. After that, plasma is divided into two equal parts into sterile vials: into one of them introduced are 600 mg/m2 of cyclophpsphane, into the other - methotrexate 40 mg/m2, and blood cells are connected with doxorubicin - 40 mg/m2. All mixtures are incubated for 30 minutes at 37°C. After that on the first and seventh day of treatment intravenously simultaneously introduced are blood cells with doxorubicin and mixtures of autoplasm with cyclophosphane and then with methotrexane are injected around tumour on its circumference.
EFFECT: method makes it possible to increase efficiency of said pathology treatment due to ensuring considerable reduction of tumour size before surgery.
SUBSTANCE: invention relates to medicine and is applied for extracorporal blood purification. Device for blood purification is made with possibility of connection to patient's blood circulation through extracorporal mains and contains at least one blood pump, control unit for control of blood pump and for control of work modes, and chamber, made with possibility of pointing at place of treatment. Chamber is chamber of colour image, which is connected with recognising device for recognising blood colour and size of occupied by blood area of image. Described is method of control over work of medical apparatus for extracorporal blood purification, in which applied is chamber of colour image, which is connected with recognising device for recognising blood colour. On the basis of colour signals determined is size of occupied by blood image surface.
EFFECT: ensuring recognising blood loss by patient during purification procedure with high degree of reliability.
18 cl, 8 dwg
SUBSTANCE: invention relates to medical equipment, namely to ultrasound sensors of flow, used in surgical systems. Elastomeric acoustic connector contains body, rim, surrounding perimeter of said body, which has internal edge, and protruding central site, located in the centre of body. Protruding central site has upper edge, lower edge and semi-cylindrical shape. Connector is also provided with partition, which connects site with rim and loop, extending from body. Protruding central site protrudes above partition level, its upper and lower edges being collinear to internal edge of rim. In addition protruding central site has section which extends in said loop. Surgical cassette contains case, valve plate, connected with one side of case and having made in it hollow, cover, connected with opposite side of case and window of transfer, located in hollow. Canal of fluid is formed in valve plate and case, acoustic connector is formed in hollow on transfer window. Surgical system contains surgical consol with site for cassette reception, ultrasound converter, located on said site and made with possibility of measuring fluid flow parameters. Acoustic connector is fixed to cassette.
EFFECT: application of invention makes it possible to increase efficiency of ultrasound signal transfer into canal of fluid.
SUBSTANCE: invention relates to field of medicine and can be applied in cardiosurgery, namely in treatment of patients with tricuspid valve pathology. Method of patient management after tricuspid valve prosthetics includes constant continuous life-long application of warfarin and aspirin, periodic application by indications of heparin, fraxiparin, freshly frozen plasma and vitamin K1, correction of warfarin dose being carried out depending on value of international normalised ratio (INR) in venous blood plasma.
EFFECT: method is aimed at prevention of thrombus-formation and hemorrhagic complications in all types of tricuspid valve prosthetics with both mechanical and biological prosthetes and makes it possible to achieve reduction of number of thrombotic and hemorrhagic complications in patients with prosthetic tricuspid valve and improvement of surgery results.
8 cl, 1 tbl