Method for detection of defatigation in operators

FIELD: medicine.

SUBSTANCE: invention refers to occupational medicine. Individual state and performance values are estimated by four-score scale. Zero points if no symptoms observed, 1 point - the symptom is slightly manifested, 2 - moderately, 3 - significantly. A fatigue index (FI) is calculated as an arithmetic mean value. Electrocardiography is recorded to estimate cardiac rhythm variability, to calculate Am, Si, LF, heart rate. A modification coefficient (M) is calculated for each value by formula: wherein Ai is a value of one of the following signs, Amax and Amin are change ranges; : Am min 3.5, Am max - 98; Si min - 2, Si max - 950; LF min - 5, LF max - 90; heart rate min - 40, heart rate max -120; a vegetative regulation index (VRI) is calculated by formula: If the FI value is 0.6 points or less, and the VRI value is 10 or less, the state is considered to be optimal; the FI value 0.6 points or less and the VRI value more than 10 show the borderline state; the FI value more than 0.6 points and the VRI value is 10 or less means the satisfactory state; while the FI value exceeding 0.6 points and the VRI value exceeding 10 providing stating defatigation.

EFFECT: method extends the range of products for detecting defatigation in operators.

7 tbl, 2 ex

 

The invention relates to occupational medicine, can be used to identify the managers of fatigue and deterioration of professionally significant psychophysiological functions.

There is a method of determining the adaptive capacity of the organism, developed for the military, which by means of the integral criterion, namely index Myznikova (IM), on the main hemodynamic parameters: heart rate (HR), blood pressure (BP) maximum, minimum HELL by the formula: IM=ADM/Admp×HR. Velicina index allows you to define reduced adaptive capacity in terms of professional activity [Myznikov I. Express-diagnostics of the functional state of divers / Illusion // Military-medical journal. - 2004. - C, No. 7. - P.35-36].

The disadvantage of this method is the determination of the only indicators of the cardiovascular system without regard to autonomic regulation and speed of visual-motor reactions, which reduces the accuracy of diagnosis of the health status of people carrier professions.

Known "Method of valuation reserve human resources" [U.S. Pat. EN 2195858 (2003)], which proposed an integrated indicator of health (SPW), which characterize the overall functional state and adaptive reserves of the body. The authors use data from the individual who tests - variation cardiointervals on Rembiesa, the rapid assessment of physical capabilities Globalarena - level physical abilities (UVB), test of visual-motor reactions on TDelegate (functional reserves of the Central nervous system), the results of determination of the emotional state (colorimetric lüscher test, the test of self-esteem SAN) detecting the level of anxiety (UT), emotional stability (ES), stress resistance (SU), an indicator of self-esteem (health, activity and mood). Given the above parameters, the indicator SPW, measured as a percentage of the maximum possible values, has grades: less than 25% - fatigue, 25-49% - satisfactory, 50-74% - good, 75-100% excellent.

The disadvantage of this method is the complexity of implementation using five survey methods, which require special equipment.

The purpose of the invention is to develop ways to identify fatigue and deterioration of professionally significant psychophysiological functions in individuals carrier professions.

When developing the method takes into account the results of monitoring of 92 managers Centre traffic South-Eastern railway JSC "Russian Railways", which in 2007-2008 at the clinic of the Department of clinical pharmacology GOU VPO ugma them. Nge the health Ministry of Russia vypolnennoe examination, including an evaluation of professionally significant psychophysiological functions to determine the rate of visual-motor reactions on computer diagnostic complex "select M. In the study of complex motor reaction (SDR) was estimated average reaction time to the green light (SDR Dresel, MS)mean reaction time on the red light (SDR Tsrc, MS), standard deviation of the identified parameters (RMS Tsrael., MS and MSE Tsrc., MS). Evaluation of the response to a moving object (WFD) was carried out on the average lead-time required (WFD Dren, MS)average latency (WFD Tspl, MS), standard deviation indicators (RMS Dren, SKO TsRP), the number of forward reactions (SIM. minutes) and the number of lags (SIM. plus when trying to stop the object at the specified point.

In the survey of managers for the first time we used a specially designed questionnaire (table 1), including 23 of the indicator. When filling in the questionnaire Respondent noted the severity of the complaints asthenic character in accordance with a four-point scale: 0 - the symptom is not observed, 1 - the symptom is weak, 2 - moderate symptom, 3 - symptom expressed significantly.

During data processing the questionnaire was expecting a new diagnostic criterion is the index of fatigue (PS) scores, as sredneuraltsy is a certain amount of points.

For the assessment of autonomic regulation in managers determined the indices of heart rate variability after a 5-minute ECG recording on the device "VARICARD-format" registered amplitude fashion (Am), the stress index (Si), low-frequency part of the spectrum (LF), heart rate (HR). Analysis of the obtained data allowed us to propose a formula for calculating a new diagnostic criterion - index of autonomic regulation (IIA). By the formula (1) was determined by the ratio of modification of each of the identified parameters:

where

M - factor modification each indicator, Ai is the value of one of the studied parameters Amax and Amin - limits of change indicators (table 2).

td align="center"> 1
Table 1
Questionnaire to identify symptoms fatigue
No.IndexThe symptom is not observedThe symptom is weakSymptom moderateSymptom expressed significantly
1Reduced efficiency01 23
2General weakness0123
3Daytime sleepiness0123
4The lowering of concentration0123
5Dissatisfaction with sleep0123
6Lower mood0123
7Periodic anxiety0123
8The reduction in activity023
9Hypersensitivity to sounds0123
10Hypersensitivity to smells0123
11Hypersensitivity to light0123
12The memory impairment0123
13Insomnia in night0123
14Tearfulness0123
15Meteos the dence 0123
16Irritability0123
17Increased fatigue at low load level0123
18Constant feeling of fatigue without load0123
19Less attention0123
20Decrease RAM0123
21The lack of a sense of vitality after a night's sleep01 23
22Any activity, even once my favorite, is "by force"0123
23Avoiding problem-solving0123

Table 2
The limits of change indicators
No.IndexAminAmaxAmax-Amin
1The mode amplitude (Am %)3,59894,5
2The stress index (Si, used)2950948
3The low-frequency part of the spectrum of heart rhythm (LF, %)5 9085
4Heart rate (HR, beats./min)4012080

As a result of reforms made by the formula (1), the coefficients of the modification indices (MAm - mode amplitude, MSi - stress index, MLF - low-frequency component of heart rate, MCS - heart rate) used to calculate the PSI by the formula (2):

The survey results 92 managers Centre traffic South-Eastern railway JSC "RZD" has allowed to allocate 4 state:

1) complaints of fatigue are not available, the balance of the autonomic system regulation, high speed visual-motor reactions; PS is in the range of 0.6 or less points, IOM is in the range equal to or less than 10 usled - state "optimal";

2) complaints of fatigue are not available, the speed of visual-motor reactions is high, but there is a tension of regulatory systems with hypersympathicotonia; PS is in the range of 0.6 or less points, more than 10 PSI usled - state border";

3) complaints of fatigue, however, maintains the balance of the autonomic system regulation and sufficient speed of visual-motor reactions; Yiwu more than 0.6 points, IOM is equal to or men who e 10 used - the status of "satisfactory";

4) the combination of signs of fatigue with the tension of regulatory systems, the speed of visual-motor reactions, unstable response with the advent of the reaction delay imposed on the signal; Yiwu more than 0.6 points, IL-more than 10 usled - state "fatigue".

According to a survey of managers of the Center of transportation, South Eastern Railways JSC "RZD" in 38 patients (41%) identified "optimal" condition - signs of fatigue were minimal, Yiwu is 0.4 plus or minus 0.04 points, temporary performance of visuo-motor reaction (SDR, WFD) and indices of heart rate variability (Si, Am) differed in small quantities (table 3), the balance of the regulatory system ensure low estimated values of the IOM, which was equal to 8.8 plus or minus 0,38 used

"Boundary" condition detected in 24 (26%)who have signs of fatigue were also minimal, Yiwu was 0.3 plus or minus 0.03 points, the performance of visual-motor reactions did not differ significantly from the performance of the group managers with the "optimal" condition, however, when determining the heart rate variability increased Si and Am pointed to the formation of autonomic imbalance and increased sympathicotonia with increasing index of autonomic regulation, IOM equal to 12.2 plus or minus 0.6 usled

p>
Table 3
Results indicators of psycho-physiological functions of train dispatchers (X±m)
Indicatorsoptimalbordersatisfactoryfatigue
n=38n=24n=16n=14
Yiwu points0,4±0,040,3±0,031,1±0,1*1,01±0,1*
IIA, c.u8,8±0,3812,2±0,6*8,7±0,412,3±0,9*
Age, years34,4±1,738,9±2,235,8±242,33±1,9
Amo, %40,4±10,360,7±2**42,2±1,458,5±3,4*
SI, usled60,3±5,3248,6±28,1**74,6±10,9234,3±31,3**
LF%39,1±2,340±2,537,2±2,339,43±5,5
HR, beats/min67,8±1,9270±263,5±270,3±2,1
SDR Dresel, MS422,5±18,8448,5±20,2436±23,6489,3±48,3*
RMS Strelof 87.3±9,5102,4±19,297±17,4110,2±25
SDR Tsrc, MS417±18439,1±18,9*434±26477±46,5*
RMS Strchrof 89.2±9,485,4±13,275±7,2a 94.6±25
WFD Dren, MS58,8±6,167,8±5,6 60±6,374,8±23
Scamin.39±7,848±7,2of 31.8±6,348,1±27
Symmetry minutes4,6±0,324,5±0,253,5±0,32,7±0,58
Symmetry plus4,3±0,34,3±0,34,4±0,45,3±0,5*
WFD TCP. plus, MS41,4±3,3250,7±5,451±5,358,8±6,4*
Scope17,1±2,223,3±3,720±2,532,6±4,1*
*p<0,05, **p<0,01 - reliability of differences with the results of the survey group 1

"Satisfactory" condition detected in 16 (17%), which was characterized by the presence of subjective complaints of fatigue, Yiwu was 1.1 plus or minus 0.1 points. However, significant changes in autonomic balance and indicators of visual-motor reactions not observed, IOM R the veins 8,7 plus or minus 0.4 usled

"fatigue" state identified in 14 patients (16%)who have complaints about fatigue combined with the increase in run-time tests of visual-motor reactions, namely SDR and the WFD, the tension of regulatory systems and the increase in the index of regulation - IIA equal to 12.3 plus or minus 0.9 usled; Yiwu equal 1,01 plus or minus 0.1 points.

Thus, on the basis of the results of the study established the value of the diagnostic criteria for identifying operators with fatigue and deterioration of professionally significant psychophysiological functions: Yiwu more than 0.6 points, Hebrew for more than 10 s. units

Individual assessment of the functional status of persons carrier professions can be illustrated by the following examples:

Example 1: SSV, 28 years old, train dispatcher at the control Center traffic South-Eastern railway, work experience in rail transport 6 years. During the examination no complaints. The results of the questionnaire are presented in table 4, the estimated value CI=0.43 points.

Avoiding problem-solving
Table 4
Form a train dispatcher MSW, 28
IndexThe symptom is not observedSymptom expressed weak, the Symptom moderateSymptom expressed significantly
Reduced efficiency1
General weakness1
Daytime sleepiness0
The lowering of concentration1
Dissatisfaction with sleep1
Lower mood0
Periodic anxiety0
The reduction in activity1
Hypersensitivity to sounds0
Hypersensitivity to smells0
Hypersensitivity to light0
The memory impairment1
Insomnia in night0
Tearfulness0
The meteosensitivity0
Irritability0
Increased fatigue at low load level0
Constant feeling of fatigue without load0
Less attention1
Decrease RAM1
The lack of a sense of vitality after a night's sleep0
Any activity, even once my favorite, is "by force"1
1

After determination of indexes of heart rate variability (Am equal to 38.1%, Si is equal to 62 used, LF is equal to 35%, heart rate is 70 beats/min) were calculated coefficients modification by the formula (1).

Table 5
The results of the calculation of the coefficients of the modification Manager SSV

Calculation of IR by the formula (2):

Manager MSW estimated Yiwu index equal to 0.43 points, IOM equal to 8.6 usled that gives the opportunity to determine its status as the "optimal": Yiwu less than 0.6 points, IR less than or equal to 10 usled

However, the absence of complaints of fatigue, balance autonomic regulation and high speed visual-motor reactions (SDR Tsrael. equal 309 MS, SDR Tsrc. equal 362 MS, WFD Dren equal to 65 MS, the WFD Terpsys 36 MS) "optimal" state confirm.

Prima is 2: SVU, 46 years old, train dispatcher at the control Center traffic South-Eastern railway, work experience in rail transport 6 years. When examining complaints of fatigue. The results of the questionnaire are presented in table 6, the estimated value Yiwu 0.91 points.

Indicators of autonomic regulation Manager SWV: Am equal to 70%, Si 363 used, LF equal to 55.2%, pulse rate equal to 5 beats./min Calculation of the coefficients of the modifications carried out by the formula (1) (table 7).

The survey Manager SWV - estimated Yiwu index of 0.91 points, IOM equal to 15.7 used that gives the basis to determine its condition as "fatigue" (PS more than 0.6 points, IOM more than 10 used) With complaints of fatigue, tension system autonomic regulation and increase run-time tests of visual-motor reactions (SDR Tsrael. equal 534 MS, SDR Tsrc. equal to 524 MS, WFD Dren equal to 92 MS, WFD Tsrps equal to 70 MS) confirmed the presence of fatigue.

The results of the survey Manager SWV indicate the need for his rehabilitation measures to improve the condition of professionally significant psychophysiological functions.

Table 6
Form a train dispatcher SUV, net
IndexThe symptom is not observedThe symptom is weakSymptom moderateSymptom expressed significantly
Reduced efficiency2
General weakness1
Daytime sleepiness1
The lowering of concentration2
Dissatisfaction with sleep2
Lower mood1
Periodically senses the alarm 1
The reduction in activity0
Hypersensitivity to sounds0
Hypersensitivity to smells0
Hypersensitivity to light0
The memory impairment1
Insomnia in night0
Tearfulness0
The meteosensitivity2
Irritability2
Increased fatigue at low load level.2
Constant feeling of fatigue without load0
Less attention1
Decrease RAM2
The lack of a sense of vitality after a night's sleep1
Any activity, even once my favorite, is "cerasela" 0
Avoiding problem-solving0

Table 7
The results of the calculation of the coefficients of the modification Manager SVV

The calculation of the index of autonomic regulation (IIA) according to the formula (2):

Thus, the proposed method allows to identify operators with a reduction of professionally significant psychophysiological functions on the background of fatigue that allows dynamic monitoring of the health status of persons carrier professions.

The duration of the tests of the proposed method are minor, including the questionnaire in 10 minutes, determination of heart rate variability - 10 minutes, the calculation of the diagnostic to the of interiew - 10 minutes. For the study of heart rate variability using domestic equipment "VARICARD-format".

How to identify fatigue in persons carrier professions, namely, that assess the following indicators: decreased performance, General weakness, daytime sleepiness, poor concentration, dissatisfaction with sleep, lower mood, periodic anxiety, decreased activity, hypersensitivity to sounds, hypersensitivity to smells, hypersensitivity to light, impaired memory, insomnia at night, tearfulness, meteosensitivity, irritability, excessive fatigue at low load levels, constant fatigue without load, decreased attention, decreased memory, no sense of vitality after a night's sleep, any activity even once my favorite, is "by force", avoiding problem-solving - four-points scale, zero points assigned if the symptom is not observed, one point if the symptom is weak, two points if a symptom is moderate, three points if a symptom is expressed significantly; calculate the fatigue index (PS) as an average value typed in all performance points; spend within five minutes of ECG recording, which is anywayt heart rate variability, the mode amplitude (Am), the stress index (Si), low-frequency (LF), heart rate (HR), followed by calculation of the coefficient modification (M) for each of the identified parameters according to the formula

where Ai is the value of one of the studied parameters, Am and Amin - limits of change indicators; Am min - 3,5, Am max - 98; Si min - 2, max Si - 950; LF min - 5, LF max - 90; HR min - 40, HR max - 120; calculate the index of autonomic regulation (IIA) according to the formula

if PS is less or equal to 0.6 points and PSI less than or equal to 10 used, the state estimate as the "optimal"; if PS is less or equal to 0.6 points, IVE more than 10 used, the state regards as "edge"; if PS more than 0.6 points, IOM is equal to or less than 10 used, the state is assessed as "satisfactory"; if PS more than 0.6 points, IOM more than 10 used, the state regards as "fatigue".



 

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3 cl, 6 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine and veterinary science, namely devices for studying tissue fluid transport in laboratory animals and may be used for studying interstitial transport and lymphatic drainage of metabolites by determining time of removal of the lymphotropic dye from tissues in a lymphatic capillary introduced in tissue. The device comprises a table 1 for small animals and a monitoring system. The table 1 is provided with a heating system 2, and the monitoring system comprises coupled optoelectronic converter 7 and computing unit 8. There are introduced a dropper for a irrigating solution, a system for the irrigating solution supply and a control unit 6 regulating the heating system 2 operation of the table 1 and a system for the irrigating solution heating and coupled with the computing unit 8. A temperature sensor is connected to the control unit 6 to form feedback.

EFFECT: invention provides higher volume and improved reliability of the obtained data.

2 cl, 4 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to therapy and rheumatology. Risk factors are determined: weight less than 60 kg; height more than 160 cm; body weight index less than 25 kg/m2; physically demanding job before the age of 25; physically demanding job after the age of 50; surgical menopause before the age of 50; singleness; bone mineral density (BMD): hip BMD less than 0.800 g/cm2; spinal BMD less than 0.900 g/cm2. The detected risk factors are graded, evaluated and used to derive prognostic coefficients F1 and F2 by formulas to be compared. If F1 is more than F2, a high risk is predicted, while the value F1 less than F2 shows a low risk of developing osteoporotic spinal fractures in females of 50 and older for the following 2-year period.

EFFECT: method enables evaluating a risk of developing low-energy spinal fractures thereby providing higher effectiveness and purpose of preventive and therapeutic measures in groups of patients with a high risk of potential fractures.

2 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to cardiology. In order to predict post-infarction remodeling of left ventricle (LV) myocardium in patients with myocardial infarction (MI) laboratory blood parameters in said category of patients are analysed. In particular, estimated are levels of N-terminal brain natriuretic peptide precursor (NTproBNP), pg/ml, matrix metalproteinase 9 (MMP9), ng/ml, highly-sensitive C-reactive protein (hs CRP), mg/l, metalproteinase 1 precursor (proMMPI), ng/l and content, %. All parameters are analysed on 3-5 day of disease and remodeling of LV myocardium in patients with MI is predicted by formula: K=0.009×MMP9+0.00032×NTproBNP+0.15×m+0.03×proMMPI+0.08×hsCRP-5.4, where K is prognostic index of post-infarction remodeling of LV myocardium. If value K>-0.85, high risk of post-infarction remodelling of LV myocardium in patients with MI is predicted.

EFFECT: method increases accuracy of prediction of post-infarction remodelling of LV myocardium in patients with MI after three months after disease beginning due to correlation analysis between levels of MMP9, proMMPl, hsCRP, NTproBNP and monocytes.

1 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to functional diagnostics, and can be used in outpatient clinics, centres of preventive medicine, sanatoria, as well as in rooms of rehabilitation medicine in form of computer programme for diagnostics. Estimation of parameters characterising functional state of cardiovascular system, physical state, biochemical status, psychological state, as well as health self-estimation is performed. Values of each parameter, corresponding to the norm, are converted into a single ten-point four-level scale. After that, obtained individual values of each parameter are converted into ten-point scale. On the basis of obtained for each individual parameter values, determined is integral index of: health self-estimation, functional state of cardio-vascular system, physical state, biochemical status, psychological state. Obtained in ten-point scale values of integral indices, which characterise functional state of human body: health self-estimation, functional state of cardio-vascular system, physical state, biochemical status, psychological state are compared with the intervals. Conclusion about their unsatisfactory, satisfactory, good or excellent state is made.

EFFECT: method makes it possible to give quantitative estimation of functional reserves in single integral four-level scale, quantitatively estimate risks of somatic disease development, form conclusion with recommendations on health improvement for people of risk groups and prevention of respective diseases.

1 tbl, 3 dwg

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to oncology. To diagnose cancer and potential resistance of malignant cells to hypoxia, prepared is cell imprint or suspension of cells, for which conditions of hypoxia are created and spectro-flowmetric analysis of said cells in dynamics of development of process of photodestruction of NAD(P)H fluorescence is performed. Conclusion about presence of tumour cells and their potential resistance to hypoxia is made by increase of NAD(P)H fluorescence intensity in conditions of darkness. Conditions of hypoxia are created by placement of cell suspension or cell imprint between two glasses for cytologic analysis. Spectro-flowmetric analysis is carried out in the range 440-470 nm, with length of excitation wave 365-370 nm.

EFFECT: method makes it possible to diagnose cancer and potential resistance of malignant cells to hypoxia.

3 cl, 6 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of sports medicine, namely to methods of laboratory diagnostics. In order to carry out laboratory diagnostics of physical activity level on organism of badminton player athlete, content of calcium and phosphorus in mouth fluid before and after physical activity is determined. If content of calcium and phosphorus before and after physical activity changes by value exceeding 9.0 and 42.9% respectively, high level of physical activity is determined; by value lower than 4.6 and 22.5 respectively, optimal level of physical activity is determined.

EFFECT: method makes it possible to carry out non-invasive laboratory diagnostics of physical activity level on organism of badminton player athlete.

1 dwg, 5 tbl

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to pediatrics. In order to diagnose biliary tract dysfunction in children acetic and propionic acids are determined in blood and saliva by gas-chromatographic method. If concentration of any of two acids in blood: acetic in the range more than 0.3264 to 1.1000 mmol/l, propionic in the range more than 0.0274 to 0.0990 mmol/l and/or if concentration of any of two acids in saliva: acetic in the range more than 0.0683 to 0.5900 mmol/l, propionic in the range more than 0.0066 to 0.0430 mmol/l, biliary tract dysfunction is diagnosed.

EFFECT: method makes it possible to diagnose biliary tract dysfunction in children.

3 ex, 3 tbl

FIELD: medicine, clinical toxicology.

SUBSTANCE: at patient's hospitalization one should gather the data of clinical and laboratory values: on the type of chemical substance, patient's age, data of clinical survey and laboratory values: body temperature, the presence or absence of dysphonia, oliguria being below 30 ml/h, hemoglobinuria, erythrocytic hemolysis, exotoxic shock, glucose level in blood, fibrinogen and creatinine concentration in blood serum, general bilirubin, prothrombin index (PTI), Ph-plasma, the state of blood clotting system. The state of every sign should be evaluated in points to be then summed up and at exceeding the sum of points being above "+20" one should predict unfavorable result. At the sum of "-13" prediction should be stated upon as favorable and at "-13" up to "+20" - prediction is considered to be doubtful.

EFFECT: higher accuracy of prediction.

2 ex, 3 tbl

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