Method for detection of defatigation in operators
SUBSTANCE: invention refers to occupational medicine. Individual state and performance values are estimated by four-score scale. Zero points if no symptoms observed, 1 point - the symptom is slightly manifested, 2 - moderately, 3 - significantly. A fatigue index (FI) is calculated as an arithmetic mean value. Electrocardiography is recorded to estimate cardiac rhythm variability, to calculate Am, Si, LF, heart rate. A modification coefficient (M) is calculated for each value by formula: wherein Ai is a value of one of the following signs, Amax and Amin are change ranges; : Am min 3.5, Am max - 98; Si min - 2, Si max - 950; LF min - 5, LF max - 90; heart rate min - 40, heart rate max -120; a vegetative regulation index (VRI) is calculated by formula: If the FI value is 0.6 points or less, and the VRI value is 10 or less, the state is considered to be optimal; the FI value 0.6 points or less and the VRI value more than 10 show the borderline state; the FI value more than 0.6 points and the VRI value is 10 or less means the satisfactory state; while the FI value exceeding 0.6 points and the VRI value exceeding 10 providing stating defatigation.
EFFECT: method extends the range of products for detecting defatigation in operators.
7 tbl, 2 ex
The invention relates to occupational medicine, can be used to identify the managers of fatigue and deterioration of professionally significant psychophysiological functions.
There is a method of determining the adaptive capacity of the organism, developed for the military, which by means of the integral criterion, namely index Myznikova (IM), on the main hemodynamic parameters: heart rate (HR), blood pressure (BP) maximum, minimum HELL by the formula: IM=ADM/Admp×HR. Velicina index allows you to define reduced adaptive capacity in terms of professional activity [Myznikov I. Express-diagnostics of the functional state of divers / Illusion // Military-medical journal. - 2004. - C, No. 7. - P.35-36].
The disadvantage of this method is the determination of the only indicators of the cardiovascular system without regard to autonomic regulation and speed of visual-motor reactions, which reduces the accuracy of diagnosis of the health status of people carrier professions.
Known "Method of valuation reserve human resources" [U.S. Pat. EN 2195858 (2003)], which proposed an integrated indicator of health (SPW), which characterize the overall functional state and adaptive reserves of the body. The authors use data from the individual who tests - variation cardiointervals on Rembiesa, the rapid assessment of physical capabilities Globalarena - level physical abilities (UVB), test of visual-motor reactions on TDelegate (functional reserves of the Central nervous system), the results of determination of the emotional state (colorimetric lüscher test, the test of self-esteem SAN) detecting the level of anxiety (UT), emotional stability (ES), stress resistance (SU), an indicator of self-esteem (health, activity and mood). Given the above parameters, the indicator SPW, measured as a percentage of the maximum possible values, has grades: less than 25% - fatigue, 25-49% - satisfactory, 50-74% - good, 75-100% excellent.
The disadvantage of this method is the complexity of implementation using five survey methods, which require special equipment.
The purpose of the invention is to develop ways to identify fatigue and deterioration of professionally significant psychophysiological functions in individuals carrier professions.
When developing the method takes into account the results of monitoring of 92 managers Centre traffic South-Eastern railway JSC "Russian Railways", which in 2007-2008 at the clinic of the Department of clinical pharmacology GOU VPO ugma them. Nge the health Ministry of Russia vypolnennoe examination, including an evaluation of professionally significant psychophysiological functions to determine the rate of visual-motor reactions on computer diagnostic complex "select M. In the study of complex motor reaction (SDR) was estimated average reaction time to the green light (SDR Dresel, MS)mean reaction time on the red light (SDR Tsrc, MS), standard deviation of the identified parameters (RMS Tsrael., MS and MSE Tsrc., MS). Evaluation of the response to a moving object (WFD) was carried out on the average lead-time required (WFD Dren, MS)average latency (WFD Tspl, MS), standard deviation indicators (RMS Dren, SKO TsRP), the number of forward reactions (SIM. minutes) and the number of lags (SIM. plus when trying to stop the object at the specified point.
In the survey of managers for the first time we used a specially designed questionnaire (table 1), including 23 of the indicator. When filling in the questionnaire Respondent noted the severity of the complaints asthenic character in accordance with a four-point scale: 0 - the symptom is not observed, 1 - the symptom is weak, 2 - moderate symptom, 3 - symptom expressed significantly.
During data processing the questionnaire was expecting a new diagnostic criterion is the index of fatigue (PS) scores, as sredneuraltsy is a certain amount of points.
For the assessment of autonomic regulation in managers determined the indices of heart rate variability after a 5-minute ECG recording on the device "VARICARD-format" registered amplitude fashion (Am), the stress index (Si), low-frequency part of the spectrum (LF), heart rate (HR). Analysis of the obtained data allowed us to propose a formula for calculating a new diagnostic criterion - index of autonomic regulation (IIA). By the formula (1) was determined by the ratio of modification of each of the identified parameters:
M - factor modification each indicator, Ai is the value of one of the studied parameters Amax and Amin - limits of change indicators (table 2).
|Questionnaire to identify symptoms fatigue|
|No.||Index||The symptom is not observed||The symptom is weak||Symptom moderate||Symptom expressed significantly|
|4||The lowering of concentration||0||1||2||3|
|5||Dissatisfaction with sleep||0||1||2||3|
|8||The reduction in activity||0td align="center"> 1||2||3|
|9||Hypersensitivity to sounds||0||1||2||3|
|10||Hypersensitivity to smells||0||1||2||3|
|11||Hypersensitivity to light||0||1||2||3|
|12||The memory impairment||0||1||2||3|
|13||Insomnia in night||0||1||2||3|
|15||Meteos the dence||0||1||2||3|
|17||Increased fatigue at low load level||0||1||2||3|
|18||Constant feeling of fatigue without load||0||1||2||3|
|21||The lack of a sense of vitality after a night's sleep||0||1||2||3|
|22||Any activity, even once my favorite, is "by force"||0||1||2||3|
|The limits of change indicators|
|1||The mode amplitude (Am %)||3,5||98||94,5|
|2||The stress index (Si, used)||2||950||948|
|3||The low-frequency part of the spectrum of heart rhythm (LF, %)||5||90||85|
|4||Heart rate (HR, beats./min)||40||120||80|
As a result of reforms made by the formula (1), the coefficients of the modification indices (MAm - mode amplitude, MSi - stress index, MLF - low-frequency component of heart rate, MCS - heart rate) used to calculate the PSI by the formula (2):
The survey results 92 managers Centre traffic South-Eastern railway JSC "RZD" has allowed to allocate 4 state:
1) complaints of fatigue are not available, the balance of the autonomic system regulation, high speed visual-motor reactions; PS is in the range of 0.6 or less points, IOM is in the range equal to or less than 10 usled - state "optimal";
2) complaints of fatigue are not available, the speed of visual-motor reactions is high, but there is a tension of regulatory systems with hypersympathicotonia; PS is in the range of 0.6 or less points, more than 10 PSI usled - state border";
3) complaints of fatigue, however, maintains the balance of the autonomic system regulation and sufficient speed of visual-motor reactions; Yiwu more than 0.6 points, IOM is equal to or men who e 10 used - the status of "satisfactory";
4) the combination of signs of fatigue with the tension of regulatory systems, the speed of visual-motor reactions, unstable response with the advent of the reaction delay imposed on the signal; Yiwu more than 0.6 points, IL-more than 10 usled - state "fatigue".
According to a survey of managers of the Center of transportation, South Eastern Railways JSC "RZD" in 38 patients (41%) identified "optimal" condition - signs of fatigue were minimal, Yiwu is 0.4 plus or minus 0.04 points, temporary performance of visuo-motor reaction (SDR, WFD) and indices of heart rate variability (Si, Am) differed in small quantities (table 3), the balance of the regulatory system ensure low estimated values of the IOM, which was equal to 8.8 plus or minus 0,38 used
"Boundary" condition detected in 24 (26%)who have signs of fatigue were also minimal, Yiwu was 0.3 plus or minus 0.03 points, the performance of visual-motor reactions did not differ significantly from the performance of the group managers with the "optimal" condition, however, when determining the heart rate variability increased Si and Am pointed to the formation of autonomic imbalance and increased sympathicotonia with increasing index of autonomic regulation, IOM equal to 12.2 plus or minus 0.6 usledp>
|Results indicators of psycho-physiological functions of train dispatchers (X±m)|
|SDR Dresel, MS||422,5±18,8||448,5±20,2||436±23,6||489,3±48,3*|
|RMS Strel||of 87.3±9,5||102,4±19,2||97±17,4||110,2±25|
|SDR Tsrc, MS||417±18||439,1±18,9*||434±26||477±46,5*|
|RMS Strchr||of 89.2±9,4||85,4±13,2||75±7,2||a 94.6±25|
|WFD Dren, MS||58,8±6,1||67,8±5,6||60±6,3||74,8±23|
|WFD TCP. plus, MS||41,4±3,32||50,7±5,4||51±5,3||58,8±6,4*|
|*p<0,05, **p<0,01 - reliability of differences with the results of the survey group 1|
"Satisfactory" condition detected in 16 (17%), which was characterized by the presence of subjective complaints of fatigue, Yiwu was 1.1 plus or minus 0.1 points. However, significant changes in autonomic balance and indicators of visual-motor reactions not observed, IOM R the veins 8,7 plus or minus 0.4 usled
"fatigue" state identified in 14 patients (16%)who have complaints about fatigue combined with the increase in run-time tests of visual-motor reactions, namely SDR and the WFD, the tension of regulatory systems and the increase in the index of regulation - IIA equal to 12.3 plus or minus 0.9 usled; Yiwu equal 1,01 plus or minus 0.1 points.
Thus, on the basis of the results of the study established the value of the diagnostic criteria for identifying operators with fatigue and deterioration of professionally significant psychophysiological functions: Yiwu more than 0.6 points, Hebrew for more than 10 s. units
Individual assessment of the functional status of persons carrier professions can be illustrated by the following examples:
Example 1: SSV, 28 years old, train dispatcher at the control Center traffic South-Eastern railway, work experience in rail transport 6 years. During the examination no complaints. The results of the questionnaire are presented in table 4, the estimated value CI=0.43 points.
|Form a train dispatcher MSW, 28|
|Index||The symptom is not observed||Symptom expressed weak, the||Symptom moderate||Symptom expressed significantly|
|The lowering of concentration||1|
|Dissatisfaction with sleep||1|
|The reduction in activity||1|
|Hypersensitivity to sounds||0|
|Hypersensitivity to smells||0|
|Hypersensitivity to light||0|
|The memory impairment||1|
|Insomnia in night||0|
|Increased fatigue at low load level||0|
|Constant feeling of fatigue without load||0|
|The lack of a sense of vitality after a night's sleep||0|
|Any activity, even once my favorite, is "by force"||1|
After determination of indexes of heart rate variability (Am equal to 38.1%, Si is equal to 62 used, LF is equal to 35%, heart rate is 70 beats/min) were calculated coefficients modification by the formula (1).
|The results of the calculation of the coefficients of the modification Manager SSV|
Calculation of IR by the formula (2):
Manager MSW estimated Yiwu index equal to 0.43 points, IOM equal to 8.6 usled that gives the opportunity to determine its status as the "optimal": Yiwu less than 0.6 points, IR less than or equal to 10 usled
However, the absence of complaints of fatigue, balance autonomic regulation and high speed visual-motor reactions (SDR Tsrael. equal 309 MS, SDR Tsrc. equal 362 MS, WFD Dren equal to 65 MS, the WFD Terpsys 36 MS) "optimal" state confirm.
Prima is 2: SVU, 46 years old, train dispatcher at the control Center traffic South-Eastern railway, work experience in rail transport 6 years. When examining complaints of fatigue. The results of the questionnaire are presented in table 6, the estimated value Yiwu 0.91 points.
Indicators of autonomic regulation Manager SWV: Am equal to 70%, Si 363 used, LF equal to 55.2%, pulse rate equal to 5 beats./min Calculation of the coefficients of the modifications carried out by the formula (1) (table 7).
The survey Manager SWV - estimated Yiwu index of 0.91 points, IOM equal to 15.7 used that gives the basis to determine its condition as "fatigue" (PS more than 0.6 points, IOM more than 10 used) With complaints of fatigue, tension system autonomic regulation and increase run-time tests of visual-motor reactions (SDR Tsrael. equal 534 MS, SDR Tsrc. equal to 524 MS, WFD Dren equal to 92 MS, WFD Tsrps equal to 70 MS) confirmed the presence of fatigue.
The results of the survey Manager SWV indicate the need for his rehabilitation measures to improve the condition of professionally significant psychophysiological functions.
|Form a train dispatcher SUV, net|
|Index||The symptom is not observed||The symptom is weak||Symptom moderate||Symptom expressed significantly|
|The lowering of concentration||2|
|Dissatisfaction with sleep||2|
|Periodically senses the alarm||1|
|The reduction in activity||0|
|Hypersensitivity to sounds||0|
|Hypersensitivity to smells||0|
|Hypersensitivity to light||0|
|The memory impairment||1|
|Insomnia in night||0|
|Increased fatigue at low load level.||2|
|Constant feeling of fatigue without load||0|
|The lack of a sense of vitality after a night's sleep||1|
|Any activity, even once my favorite, is "cerasela"||0|
|The results of the calculation of the coefficients of the modification Manager SVV|
The calculation of the index of autonomic regulation (IIA) according to the formula (2):
Thus, the proposed method allows to identify operators with a reduction of professionally significant psychophysiological functions on the background of fatigue that allows dynamic monitoring of the health status of persons carrier professions.
The duration of the tests of the proposed method are minor, including the questionnaire in 10 minutes, determination of heart rate variability - 10 minutes, the calculation of the diagnostic to the of interiew - 10 minutes. For the study of heart rate variability using domestic equipment "VARICARD-format".
How to identify fatigue in persons carrier professions, namely, that assess the following indicators: decreased performance, General weakness, daytime sleepiness, poor concentration, dissatisfaction with sleep, lower mood, periodic anxiety, decreased activity, hypersensitivity to sounds, hypersensitivity to smells, hypersensitivity to light, impaired memory, insomnia at night, tearfulness, meteosensitivity, irritability, excessive fatigue at low load levels, constant fatigue without load, decreased attention, decreased memory, no sense of vitality after a night's sleep, any activity even once my favorite, is "by force", avoiding problem-solving - four-points scale, zero points assigned if the symptom is not observed, one point if the symptom is weak, two points if a symptom is moderate, three points if a symptom is expressed significantly; calculate the fatigue index (PS) as an average value typed in all performance points; spend within five minutes of ECG recording, which is anywayt heart rate variability,
the mode amplitude (Am), the stress index (Si), low-frequency (LF), heart rate (HR), followed by calculation of the coefficient modification (M) for each of the identified parameters according to the formula
where Ai is the value of one of the studied parameters, Am and Amin - limits of change indicators; Am min - 3,5, Am max - 98; Si min - 2, max Si - 950; LF min - 5, LF max - 90; HR min - 40, HR max - 120; calculate the index of autonomic regulation (IIA) according to the formula
if PS is less or equal to 0.6 points and PSI less than or equal to 10 used, the state estimate as the "optimal"; if PS is less or equal to 0.6 points, IVE more than 10 used, the state regards as "edge"; if PS more than 0.6 points, IOM is equal to or less than 10 used, the state is assessed as "satisfactory"; if PS more than 0.6 points, IOM more than 10 used, the state regards as "fatigue".
SUBSTANCE: invention refers to medicine, namely cardiology, normal physiotherapy, pathological physiotherapy. A daily curve of blood pressure is recorded. It is followed by spectral analysis by the method of continuous wavelet transformation. A frequency power of the blood pressure curve a is determined in the moment b by mathematical formula. Scalograms are drawn on the basis of the wavelet coefficient on the segment [bj, bj] by mathematical formula. Physiologically relevant frequency ranges are selected at the scalograms on the basis of distances between adjacent local minimums on the scalogram curve by formula.
EFFECT: method provides weak influence of vegetative nervous system and humoral effects on the blood pressure curve at the various stages of ontogenesis, in health and disease, both in rest, and in transition processes.
1 ex, 2 dwg
SUBSTANCE: invention refers to rehabilitation and preventive medicine, cardiology, therapy. It involves drug-induced therapy and a course of cardiorespiratory training with biological feedback (BF) presenting a cardiorhythmography (CRG) and a reference cyclic curve (RCC) to the patient to be matched under continuous visual control. It is followed by active (BF-assisted) and non-active (BF-unassisted) 2-minute tests with the first and last test of each session are non-active (NT). The first NT involves recording reference data of patient's cardiorespiratory system with evaluating the parameters as follows: RCC amplitude, period and continuous component matched with average heart rate on the following active test (AT). The test are automatic, individual for the patient as for the moment of testing with the use of an apparatus for functional psychophysiological correction comprising units described in the patent claim. Each following AT requires forming RCC with the use of average heart rate, amplitude and period on the basis of spectral analysis of CRG and CC of the previous AT. In the beginning of the procedure, the patient is set up to successful completion of the task, 5 s after the beginning of each AT, an audio signal (1 kHz, 300 ms, 30 dB above a threshold of audibility) is supplied. Before the beginning of the course and after each session and the whole course, the patient is tested to determine a level of reactive and personal anxiety and depression by stating the required number of sessions for recovery of cardiorespiratory synchronisation and normal heart rate and blood pressure. Before the first NT and after each AT, capnometry is used to determine the concentration of CO2 in expired air. If observing decrease, respiratory depth is corrected. If maintaining CO2 in expired air after each following AT less than 95% from reference, respiratory depth is corrected during the following AT under control of capnometry to achieve the concentration of not less than 95% from reference. The therapeutic course includes at least 5 sessions, 1 session daily or every second day to recover the respiratory pattern lost due to the disease and the biorhythmological structure of heart rate.
EFFECT: method eliminates subjectivity of the respiratory parameters specified by a searcher, and hyperventilation syndrome due to objective control of respiratory depth with improved heart rate variability.
1 ex, 3 tbl, 3 dwg
SUBSTANCE: group of inventions relates to medicine and medical equipment, namely, to systems of image obtaining, in particular, to computed tomography. In first version of implementation system of image obtaining contains component of window management, which receives ECG signal, which contains premature cardiac cycle and preliminarily obtained X-ray projection data of beating heart. ECGF signal is synchronised with the time of preliminarily obtained X-ray projection data of beating heart. Component of window management places first reconstruction window within the limits of the first cardiac cycle to correspond desirable cardiac phase of preliminarily obtained X-ray projection data, when premature cardiac cycle ensures correspondence of the first reconstruction window to another cardiac phase. Such system contains device of reconstruction which reconstructs projection data, corresponding to multitude of windows of reconstruction of different cardiac cycles to create image data, characteristic of desirable heart phase. In second version of implementation system contains component of window management which deletes first reconstruction window corresponding to suboptimal cardiac phase of preliminarily obtained X-ray projection data of beating heart resulting from abnormal signal in ECG signal. ECG signal is presented in time with preliminarily obtained X-ray projection data of beating heart on multitude of heart cycles, and component of window management adds replacing reconstruction window to optimise set of data for reconstruction, basing on abnormal signal and available preliminarily obtained projection. System also contains reconstruction device which reconstructs set of data for reconstruction in order to create image data characteristic of desirable phase of heart beating. In third version of implementation system contains recommendation component which recommends reconstruction window for cardiac phase within the multitude of preliminarily obtained successive cardiac cycles based on ECG signal and arrhythmia in it, and device of reconstruction, which reconstruct data corresponding to data for each cycle, corresponding to reconstruction window. ECG signal is obtained with simultaneous scanning of beating heart by of computed tomographic scanner. In fourth version of implementation system contains component of window management which automatically changes location or moves first window of reconstruction for cardiac cycle on the basis of premature cardiac cycle within ECG, which is signal synchronised with preliminarily obtained X-ray projection data of beating heart; recommendation component which automatically recommends, at least, one additional reconstruction window, on the basis of premature cardiac cycle; and reconstruction device which reconstructs data, corresponding to reconstruction windows. In order to obtain image received is ECG signal which contains premature cardiac cycle, ECG signal is synchronised in time with preliminarily obtained X-ray projection data of beating heart by multitude of cycles of heart beating. After that, first reconstruction window is moved within the limits of first cardiac cycle, which corresponds to data, different from desirable cardiac phase as a result of premature cardiac cycle. Each from multitude of cardiac cycles contains reconstruction window. Then preliminarily obtained projection data, corresponding to multitude of reconstruction windows, are reconstructed to create image data, characteristic of desirable phase of heart beating. Group of inventions also contains computer-readable data carrier, which stores commands, which, when performed by computer, make computer perform claimed method of image obtaining.
EFFECT: application of claimed group of inventions will make it possible to increase quality of resulting data of reconstructed image.
34 cl, 10 dwg
SUBSTANCE: invention relates to medicine, namely to pediatrics. In children of pre-school age with tuberculosis of intrathotacic lymph nodes indices of heart rhythm variability are determined: rhythmograms - interinterval differences RMSSD (ms), coefficient of variability CV (%), spectrograms - total spectrum power TR (ms2), very low frequency waves of spectrum VLF (ms2), low frequency waves of spectrum LF (ms2), high frequency waves of spectrum HF (ms2). If their values equal: interinterval differences RMSSD - 76.8±3.92, coefficient of variability CV - 9.9±0.50, total spectrum power TR - 3437±175.3, very low frequency waves of spectrum VLF - 1067±54.4, low frequency waves of spectrum LF - 1003±51.2, high frequency waves of spectrum HF - 1900.2±96,9 vegetative dysfunction is diagnosed.
EFFECT: method increases reliability of diagnostics of impairment of vegetative regulation in children with tuberculosis.
1 tbl, 1 ex
SUBSTANCE: invention relates to medicine, namely to pediatrics. Parameters of cardiorhythmogram (CRG) are registered in lying position: at rest - heart rate, SDNN index; tension index (TI); total spectrum power - Total; value of power in range VLF; value of power in range LF; value of power in range HF. After that in standing position reactivity of sympathetic nervous system is determined by Lf/HF index. In five minutes in lying position recovery of initial heart rate, total spectrum power - Total, increase or reduction of initial power in range of waves: VLF, LF, HF are determined. On the basis of CRG indices, it is estimated which type of cardiac rhythm regulation level prevails: reflex or humoral-metabolic; vegetative balance of sympathetic and parasympathetic impact on cardiac rhythm; reactivity of sympathetic nervous system to functional load: adequate or inadequate. Favourable adaptation is predicted if reflex type of cardiac rhythm regulation prevails over humoral-metabolic, at rest balance of sympathetic and parasympathetic impact on cardiac rhythm is determined, under functional load adequate reactivity of sympathetic nervous system is observed. Unfavourable prediction of adaptation is made if reflex type of cardiac rhythm regulation prevails, but at rest sympathetic or parasympathetic impact on cardiac rhythm is observed, under functional load adequate or increased reactivity of sympathetic nervous system is observed. Unfavourable prediction is made if humoral-metabolic type of level of cardiac rhythm regulation prevails, at rest sympathetic impact on cardiac rhythm prevails and under functional load - inadequate: increased or reduced reactivity of sympathetic nervous system is observed.
EFFECT: method makes it possible to increase reliability of prediction of children's adaptation school.
4 tbl, 3 ex
SUBSTANCE: invention refers to medicine, pulmonology and perinatology. A pregnant woman suffering bronchial asthma of slight severity, in an attack-free period is examined for the functional state of the vegetative nervous system by cardiorhythmography. Detecting a prevailing effect of the sympathetic nervous system by regional lung rheography technique is used to determine a degree of involvement (%) of a medium region of a left lung in air fill (DOmrll%) and a pulse wave propagation time between the heart and the medium region of the left lung (gamrll). It is followed by a discriminant equation: D=-0.054×DOmrll%-11.781×gamrll. If the value D is equal to or more than -2.55, a baby in a in satisfactory condition is expected to be born, while D being less than -2.55, a baby in asphyxia is predicted.
EFFECT: method provides higher prediction reliability.
SUBSTANCE: invention relates to the field of medicine, namely to methods of heart functional state diagnostics. Cardiorhythmogram is registered, integral and amplitude parameters are determined, their phase characteristics are fixed. As position of phase characteristics vector changes, building of elementary geometric figures of said vector travel on phase plane is carried out. From obtained building of elementary geometric figures number of geometric figures with sides '2', '3', '4',…'15', as well as number of elementary figures "point", reflecting zero increments of R-R cardiointervals are determined, plotting them on diagram of ratings of elementary geometric figures as "1". Presence of pathology is determined if value of number of said figures is higher than 3% from total number of figures.
EFFECT: method extends arsenal of means for control of heart functional state.
14 dwg, 4 tbl
SUBSTANCE: invention relates to medicine and can be used in cardiology, cardiac surgery, physiology. In patients with ischemic heart disease thermographic examination of upper extremities is carried out. ECG monitoring is performed. Analysis of heart rhythm variability is realised. Test with sublingual introduction of nitroglycerin is carried out. Presence of vasodilating reaction to nitroglycerin is determined by values of temperature of left hand fingers, index of tension (voltage) and RMSSD index.
EFFECT: claimed invention extends functional possibilities of determining clinical efficiency of nitrates in treatment of patients with IHD.
2 ex, 1 tbl
SUBSTANCE: invention refers in particular to instant diagnosis the CSV of the patient on the basis of the cardiac rhythm variability test. RR intervals (RRI) of the patient are registered and their length is measured. Then the dynamic range of RRI by means of excluding extra systoles which length T3 exceeds double value of the minimum length of RRI 2Tmin and the average length of RRI Tavr in the dynamic range with excluded extra systoles is calculated and changed by the extra systoles on the RRI of length Tavr. Autocorrelation function of the dynamic range RRI is formed and converted to the autocorrelation matrix. The state of the patient's cardiovascular system P is judged by the value of the composite index of the patient's health P, which contains the new index of the regulatory systems tension taking into account maximum and minimum proper values of the autocorrelation matrix and age of the patient in years.
EFFECT: means provides simplification, urgency, advanced objectiveness and accuracy of the diagnosis the cardiovascular system of the patient.
2 cl, 2 dwg, 3 ex
SUBSTANCE: invention relates to field of medicine, namely to functional diagnostics. Cardiorhythmographic examination with analysis of heart rhythm is carried out. Vegetative reactivity is determined from the fifth minute of staying in orthoposition, coefficient of adaptation reserve (CAR) is calculated by formula: CAR=TI3/TI2, where TI3 is tension index, calculated by Baevskiy, starting from the fifth minute of staying on orthoposition; TI2 is tension index, calculated by Baevskiy, immediately after transition into orthostasis. By specific values of tension index and CAR and their combination level of vegetative reactivity and state of vegetative adaptation reserve are estimated.
EFFECT: method makes it possible to reduce examination time preserving high result accuracy.
6 tbl, 3 ex
SUBSTANCE: patient's skin condition is diagnosed by assessing the effectiveness of fibroblast colony-formation, as a parameter describing regeneration cell potential and percentage of dense and diffuse colonies in a cell culture as parameters describing proliferative cell potential. The effectiveness of colony-formation is calculated as percentage ratio of the formed colonies of cell count more than 20 to total explanted cell count. In the other version, a proliferation parameter describing proliferative cell potential is calculated by formula: PP=[1(DC)+2(MC)+3(DenseC)]/100(%), wherein PP is the proliferation parameter; DC is percentage of diffuse colonies, (%); MC is percentage of mixed colonies, (%); DenseC is percentage of dense colonies, (%).
EFFECT: application of the given group of inventions enables diagnosing the condition of fibroblast population of patient's skin.
4 cl, 6 dwg, 6 ex, 3 tbl
SUBSTANCE: invention refers to a method for prediction of cervical cancer in benign and pre-cancer cervical processes in females of reproductive age involving description of clinical risk factors of developing cervical cancer, MLH1, HIC1, RASSF1A, MGMT, N33, CDH1 gene methylation in a cervical biopsy material and calculation of a probability coefficient of developing cervical cancer p. If the value p is more than 0.6, a high probability of developing cervical cancer is predicted, the value p equal to 0.3-0.59 enables predicting a moderate probability of developing cervical cancer, and if the value p is less than 0.29, a low probability of developing cervical cancer is predicted.
EFFECT: method provides more accurate prediction of cervical cancer in benign and pre-cancer cervical diseases in females of reproductive age.
SUBSTANCE: method for preparing samples of non-decalcified articular cartilage with subjacent subchondral bone for multipurpose study involves tissue preparation for transmission electronic microscopy. Tissue samples 3-4 mm are taken and dehydrated in the mode of smooth alcohol to acetone transition with time increase at the stages from 70% to 96% of alcohol per 1 h. Then they are dehydrated in 2 changes 70% of alcohol for 1 h, in 2 changes 80% of alcohol for 1 h, in 2 changes 90% of alcohol for 1 h, in 2 changes 96% of alcohol for 1 h, in 2 changes 100% of alcohol for 30 min, in 2 changes 100% of acetone for 30 min. It is followed by impregnation in the mode of smooth alcohol to acetone transition: resin-acetone composition 100% 3:1 for 2 h, resin-acetone composition 100% 1:1 for 2 h, resin-acetone composition 100% 1:3 for 2 h. Before polymerisation, the sampled are impregnated by resin at room temperature to 10 days.
EFFECT: provided qualitative and quantitative study with the use of microscopy techniques.
3 cl, 6 dwg
SUBSTANCE: invention refers to medicine and veterinary science, namely devices for studying tissue fluid transport in laboratory animals and may be used for studying interstitial transport and lymphatic drainage of metabolites by determining time of removal of the lymphotropic dye from tissues in a lymphatic capillary introduced in tissue. The device comprises a table 1 for small animals and a monitoring system. The table 1 is provided with a heating system 2, and the monitoring system comprises coupled optoelectronic converter 7 and computing unit 8. There are introduced a dropper for a irrigating solution, a system for the irrigating solution supply and a control unit 6 regulating the heating system 2 operation of the table 1 and a system for the irrigating solution heating and coupled with the computing unit 8. A temperature sensor is connected to the control unit 6 to form feedback.
EFFECT: invention provides higher volume and improved reliability of the obtained data.
2 cl, 4 dwg
SUBSTANCE: invention refers to medicine, namely to therapy and rheumatology. Risk factors are determined: weight less than 60 kg; height more than 160 cm; body weight index less than 25 kg/m2; physically demanding job before the age of 25; physically demanding job after the age of 50; surgical menopause before the age of 50; singleness; bone mineral density (BMD): hip BMD less than 0.800 g/cm2; spinal BMD less than 0.900 g/cm2. The detected risk factors are graded, evaluated and used to derive prognostic coefficients F1 and F2 by formulas to be compared. If F1 is more than F2, a high risk is predicted, while the value F1 less than F2 shows a low risk of developing osteoporotic spinal fractures in females of 50 and older for the following 2-year period.
EFFECT: method enables evaluating a risk of developing low-energy spinal fractures thereby providing higher effectiveness and purpose of preventive and therapeutic measures in groups of patients with a high risk of potential fractures.
2 tbl, 3 ex
SUBSTANCE: invention relates to field of medicine, namely to cardiology. In order to predict post-infarction remodeling of left ventricle (LV) myocardium in patients with myocardial infarction (MI) laboratory blood parameters in said category of patients are analysed. In particular, estimated are levels of N-terminal brain natriuretic peptide precursor (NTproBNP), pg/ml, matrix metalproteinase 9 (MMP9), ng/ml, highly-sensitive C-reactive protein (hs CRP), mg/l, metalproteinase 1 precursor (proMMPI), ng/l and content, %. All parameters are analysed on 3-5 day of disease and remodeling of LV myocardium in patients with MI is predicted by formula: K=0.009×MMP9+0.00032×NTproBNP+0.15×m+0.03×proMMPI+0.08×hsCRP-5.4, where K is prognostic index of post-infarction remodeling of LV myocardium. If value K>-0.85, high risk of post-infarction remodelling of LV myocardium in patients with MI is predicted.
EFFECT: method increases accuracy of prediction of post-infarction remodelling of LV myocardium in patients with MI after three months after disease beginning due to correlation analysis between levels of MMP9, proMMPl, hsCRP, NTproBNP and monocytes.
1 tbl, 3 ex
SUBSTANCE: invention relates to field of medicine, namely to functional diagnostics, and can be used in outpatient clinics, centres of preventive medicine, sanatoria, as well as in rooms of rehabilitation medicine in form of computer programme for diagnostics. Estimation of parameters characterising functional state of cardiovascular system, physical state, biochemical status, psychological state, as well as health self-estimation is performed. Values of each parameter, corresponding to the norm, are converted into a single ten-point four-level scale. After that, obtained individual values of each parameter are converted into ten-point scale. On the basis of obtained for each individual parameter values, determined is integral index of: health self-estimation, functional state of cardio-vascular system, physical state, biochemical status, psychological state. Obtained in ten-point scale values of integral indices, which characterise functional state of human body: health self-estimation, functional state of cardio-vascular system, physical state, biochemical status, psychological state are compared with the intervals. Conclusion about their unsatisfactory, satisfactory, good or excellent state is made.
EFFECT: method makes it possible to give quantitative estimation of functional reserves in single integral four-level scale, quantitatively estimate risks of somatic disease development, form conclusion with recommendations on health improvement for people of risk groups and prevention of respective diseases.
1 tbl, 3 dwg
SUBSTANCE: invention relates to field of medicine, namely to oncology. To diagnose cancer and potential resistance of malignant cells to hypoxia, prepared is cell imprint or suspension of cells, for which conditions of hypoxia are created and spectro-flowmetric analysis of said cells in dynamics of development of process of photodestruction of NAD(P)H fluorescence is performed. Conclusion about presence of tumour cells and their potential resistance to hypoxia is made by increase of NAD(P)H fluorescence intensity in conditions of darkness. Conditions of hypoxia are created by placement of cell suspension or cell imprint between two glasses for cytologic analysis. Spectro-flowmetric analysis is carried out in the range 440-470 nm, with length of excitation wave 365-370 nm.
EFFECT: method makes it possible to diagnose cancer and potential resistance of malignant cells to hypoxia.
3 cl, 6 dwg, 1 ex
SUBSTANCE: invention relates to field of sports medicine, namely to methods of laboratory diagnostics. In order to carry out laboratory diagnostics of physical activity level on organism of badminton player athlete, content of calcium and phosphorus in mouth fluid before and after physical activity is determined. If content of calcium and phosphorus before and after physical activity changes by value exceeding 9.0 and 42.9% respectively, high level of physical activity is determined; by value lower than 4.6 and 22.5 respectively, optimal level of physical activity is determined.
EFFECT: method makes it possible to carry out non-invasive laboratory diagnostics of physical activity level on organism of badminton player athlete.
1 dwg, 5 tbl
SUBSTANCE: invention relates to field of medicine, namely to pediatrics. In order to diagnose biliary tract dysfunction in children acetic and propionic acids are determined in blood and saliva by gas-chromatographic method. If concentration of any of two acids in blood: acetic in the range more than 0.3264 to 1.1000 mmol/l, propionic in the range more than 0.0274 to 0.0990 mmol/l and/or if concentration of any of two acids in saliva: acetic in the range more than 0.0683 to 0.5900 mmol/l, propionic in the range more than 0.0066 to 0.0430 mmol/l, biliary tract dysfunction is diagnosed.
EFFECT: method makes it possible to diagnose biliary tract dysfunction in children.
3 ex, 3 tbl
FIELD: medicine, clinical toxicology.
SUBSTANCE: at patient's hospitalization one should gather the data of clinical and laboratory values: on the type of chemical substance, patient's age, data of clinical survey and laboratory values: body temperature, the presence or absence of dysphonia, oliguria being below 30 ml/h, hemoglobinuria, erythrocytic hemolysis, exotoxic shock, glucose level in blood, fibrinogen and creatinine concentration in blood serum, general bilirubin, prothrombin index (PTI), Ph-plasma, the state of blood clotting system. The state of every sign should be evaluated in points to be then summed up and at exceeding the sum of points being above "+20" one should predict unfavorable result. At the sum of "-13" prediction should be stated upon as favorable and at "-13" up to "+20" - prediction is considered to be doubtful.
EFFECT: higher accuracy of prediction.
2 ex, 3 tbl