Composition showing restorative, general tonic and antidepressant action

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry and may be used in sports medicine, as well as for prevention and correction of the disorders caused by the body exposure to stress and other unfavourable environmental factors. A composition showing restorative, general tonic and antidepressant action contains ginseng root extract, L-glutamine, eleuterococcus extract, native royal jelly, taurine, guarana extract, licorice root and rhizome extract, zinc gluconate, fructose, citric acid, a preserving agent, a sweetening agent, an aromatiser and water.

EFFECT: composition provides good bioavailability and wide spectrum of therapeutic action.

2 ex

 

The invention relates to pharmaceutical industry and can be used in sports medicine, as well as for the prevention and correction of disorders due to exposure to stress and other adverse environmental factors.

Known means for reducing the feeling of fatigue, a type of Amphetamine (Mashkovsky PPM Medicines, M. Medicine, vol. 1 and 2, 1993).

Its use is limited because of side effects. Used to relieve fatigue tonics from vegetable raw materials: alcoholic tinctures ginseng, Siberian ginseng, schisandra, etc. (Mashkovsky PPM Medicines, M. Medicine, vol. 1 and 2, 1993). They are used as means of maintenance therapy.

Also known commercial product "Revill Ginseng Plus" is a trading name of drug company Ranbaxy, containing ginseng extract (standardized concentrated extract of ginseng, corresponding 212,5 mg ginseng root) to 42.5 mg; vitamin a (retinolpalmitat) IP5000ME; vitamin B1IP 5 mg; vitamin b2IP 3 mg; vitamin b6IP 1 mg; vitamin b12IP-2 mcg; vitamin C IP 40 mg; vitamin D3IP-500ME; vitamin E USP 10 mg; nicotinamide IP 20 mg; calcium D-Pantothenate USP 5 mg; folic acid IP 0.5 mg; iron fumarate IP 15,0 mg; copper sulfate, equivalent copper 0.5 mg; potassium sulfate, equivalent to Cali is 2 mg; manganese monopersulfate USP, equivalent to the manganese 0.5 mg; magnesium sulphate IP equivalent to 3.0 mg magnesium; zinc oxide IP, equivalent to zinc 0.5 mg; dibasic calcium phosphate IP, equivalent to calcium 75,0 mg equivalent phosphorus 58,0 mg; potassium iodide, equivalent iodine 0.1 mg; choline bitartrate 50 mg; DL-methionine USP 50 mg; Inositol 50 mg

This composition can be used in stressful situations, difficult falling asleep, irritability. However, the introduction of significant amounts of vitamins are not always justified. And, in addition, with long-term use of the drug can cause side effects in action on the gastrointestinal tract.

As a prototype known tonic composition containing vitamin b1, vitamin C, taurine, caffeine, organic acid, Ginkgo biloba, guarana extract, sweetener, preservative, flavoring, dye and water (US 2009186127).

The technical object of the present invention is to provide a composition with an expanded range of pharmacological activity and increased bioavailability due to the proposed form of acceptance in the form of a solution.

The goal of the project is achieved by a composition having a toning, firming and antidepressant action containing ginseng extract citric acid, taurine, guarana extract, sweetens the l, preservative, flavouring, water, characterized in that it further comprises L-glutamine, extract of Siberian ginseng, Royal jelly, extract roots with rhizomes of licorice, zinc gluconate, fructose, with the following ratio of ingredients, wt.%:

L-Glutamine with 0.1-25

Extract of Eleutherococcus 0,1-15

Royal jelly is 0.1-10

Taurine 0.1 to 10

Guarana extract is 0.5 to 10

The ginseng root extract of 0.1-5

The root extract from licorice roots of 0.05-5

Zinc gluconate 0,05-1,5

Fructose - 1-10

Citric acid is 0.05-2

Preservative 0,01-1,0

Sweetener of 0.001 to 1.5

Flavor 0,001-0,5

Water to 100

Ginseng extract contains a complex of biologically active substances, mainly saponine glycosides-ginsenoside, as well as essential oils, styrene, peptides, vitamins and minerals. Ginseng extract is considered to be an adaptogen, that is, improves the tolerance of adverse conditions, including stress, increases the nonspecific resistance of the organism. Ginseng extract has a stimulating effect on the Central nervous system, improves mental and physical performance, stimulates metabolism and energy, cellular activity, improves the absorption of oxygen by the cells of the body and thus, helps to significantly increase the energy potential of man. Ginseng extract to regulate the duty to regulate the endocrine glands, slightly increases the HELL.

Taurine plays an important role in lipid metabolism, helps normalize the function of cell membranes, optimization of energy and metabolic processes, the preservation of the electrolyte composition of the cytoplasm (due to accumulation of potassium ions and calcium), is a member of the pair of bile acids (taurocholate, taurodezoksiholevoy)the emulsification of fats in the intestine. In the brain acts as a neurotransmitter, inhibitory synaptic transmission, has anticonvulsant and cardiotonic activity.

Rhizome and roots of licorice contains glycyrrhizin (23%), flavonoids, essential oil, ascorbic acid. Licorice is glycyrrhizin acid, its structure is similar to a hormone produced by the adrenal cortex (cortisol). It regulates the body's water and salt metabolism. Glycyrrhizin acid found in licorice has anti-inflammatory and antiallergic effect.

Zinc gluconate is a source of zinc, which is part of the enzyme superoxide dismutase, preventing the formation of intracellular free radicals in the process of redox reactions;

promotes protein synthesis and the formation of connective tissue;

normalizes the function of the prostate gland;

participates in is nThese gonadotropin;

is part of a complex enzyme systems that form DNA, especially involved in the regeneration of nerve cells.

Guarana extract contains a crystalline substance called guaranine, similar to tannin, found in tea, caffeine from coffee and other components of the tea, Cola and cocoa. Natural combination of these alkaloids has a unique harmonious balance. In addition, guarana (guarana extract) contains 5.5% of amides, 7% resin, 0.6% saponin and traces of amino acids, adenine and guanine, sodium, magnesium, potassium, calcium and vitamin b1. Thanks to the unique composition of guarana (guarana) is a strong stimulant of the nervous system, increase energy metabolism. Guarana (guarana extract) is used as a tonic for the exhaustion, fatigue, stimulates physical activity and improves muscle.

The composition may contain Royal jelly in dried or native form, the amount of which is calculated based on the dry substance content.

As the extracts may contain or thick, or dry, or liquid extract.

Water used as a solvent, may be deionized, purified injection.

Instead of fructose allowed to use other sugars permitted for use in food PR the industry, or a combination of both.

The tool may further comprise a pharmaceutically and pharmacologically compatible minerals and their compounds, carotenoids, and/or flavonoids, antioxidants, enzymes, or other medicinal substances, amino acids, protein, vitamins, hormones (hormone-like substances) and sterols.

The advantages of the present invention include the fact that:

the activity of the composition determined by the maximum concentration of active compounds in a minimum volume of solvent;

- the subject is a composition that can be used for immediate consumption;

- concentration of active components allow the use of the composition in a minimum amount, calculated for a single admission;

- convenience features one receiving all doses (eliminates the possibility of skipping the regular reception during the day or overdose due to repeated administration);

the composition does not contain doping substances included in the WADA list, psychotropic substances,

the concentration of the composition useful for inclusion in a more dilute preparations (for example, drinks, sprays, syrups, purees), the concentration of active substances grounded average normal physiological needs of the organism to the concentration and increase stamina, improve adaptogenic properties;

- the presence in the composition of the polar solvent can increase the bioavailability of active ingredients, characterized by a hydrophilic properties;

- the presence of a number of compatible chemical and biopharmaceutical active substances causes the extension of the pharmacological activity of the composition.

Technology composition is as follows.

Under sterile conditions weigh the exact amount of these ingredients and dissolve in water: fructose, the extract from the roots of Eleutherococcus, L-glutamine, taurine, Royal jelly, extract roots with rhizomes of licorice, ginseng root extract, zinc gluconate, preservative, citric acid, sweetener, flavouring. Thoroughly homogenized, bring the volume to 100%, the resulting solution was re-mix thoroughly, pass the mixture through a homogenizer under high pressure, filtered and poured into containers.

Specific example 1

Under sterile conditions weigh the exact amount of these ingredients and mix: 7% water, fructose 10%, extract of Siberian ginseng 15%, L-glutamine 25%, taurine 10%, Royal jelly 10%, extract of roots with rhizomes of licorice 5%, ginseng root extract 5%, zinc gluconate 1.5%), preservative (sorbic acid) and 1.0%citric acid 2%, sweetener (Sucralose) 1.5%), flavouring (natural raspberry) of 0.5%. Thoroughly is homogenized, the volume was adjusted with water to 100%, the resulting solution was re-mix thoroughly, pass the mixture through a homogenizer under high pressure, filtered and poured into containers.

Specific example 2

Under sterile conditions weigh the exact amount of these ingredients in 50% water: fructose 1%, extract of Siberian ginseng 0.1%of L-glutamine with 0.1%, taurine 0,1%, Royal jelly 0.1%, the extract of the roots with rhizomes of licorice 0.05%, ginseng root extract of 0.1%, zinc gluconate 0.05%, the preservative to 0.01%citric acid 0.05%, sweetener (stevioside), 0.001%, flavouring (natural orange) 0,001%. Thoroughly homogenized, the volume was adjusted with water to 100%, the resulting solution was re-mix thoroughly, pass the mixture through a homogenizer under high pressure, filtered and poured into containers.

Specific example 3

Under sterile conditions weigh the exact amount of these ingredients in 50% deionized water: glucose 1%, a dry extract from the roots of Eleutherococcus 0.1%of L-glutamine with 0.1%, taurine 0.1 percent, native Royal jelly 0,1%, dense extract of the roots with rhizomes of licorice 0.05%, the liquid extract of ginseng roots of 0.1%, zinc gluconate 0.05%, the lutein (flavonoid) of 0.1%, 0.05% lycopene (a carotenoid), 0,002% chromium picolinate (trace), 0.1% magnesium lactate (macronutrients), 0.02% soy isoflavones (hormone-like substances), 0.02% of the ETA-ecdysone (sterols), 0.02% ascorbyl-sodium palmitate (antioxidant) preservative to 0.01%citric acid 0.05%, sweetener (stevioside), 0.001%, flavouring (natural orange) 0,001%. Thoroughly homogenized, the volume was adjusted with deionized water to 100%, the resulting solution was re-mix thoroughly, pass the mixture through a homogenizer under high pressure, filtered and poured into containers.

Specific example 4

Under sterile conditions weigh the exact amount of these ingredients in a 25% water injection: sucrose 27%, the extract from the roots of Eleutherococcus 10%, L-glutamine 3%, taurine 3%, liofilizirovannoe Royal jelly 3%, extract of roots with rhizomes of licorice 5%, ginseng root extract 5%, zinc gluconate 1%preservative 1% (0.005% of potassium sorbate, 0.005% sodium benzoate), citric acid 5%, natural-identical flavouring lemon 0.5%, and the sweetener of 1.5% (0.05% acetylcholine potassium, 0.05% sodium cyclamate, 0,05% sodium saccharin). Thoroughly homogenized, bring the volume of water for injection to 100%, the resulting solution was re-mix thoroughly, pass the mixture through a homogenizer under high pressure, filtered and poured into containers (bottles, the most convenient volume for a single ingestion - 11 ml).

Specific example 5

Under sterile conditions weigh the exact amount of these ingredients at 25% purified water: sah who rose 27%, the extract from the roots of Eleutherococcus 10%, L-glutamine 3%, taurine 3%, liofilizirovannoe Royal jelly 3%, extract of roots with rhizomes of licorice 5%, ginseng root extract 5%, zinc gluconate 1%preservative 1% (0.005% of potassium sorbate, 0.005% sodium benzoate), citric acid 5%, 0.01% lutein, 0.05% of rutin, 0.001% of tocopherol, 0.1% bromeline, 0.005% caffeine, 0.1% of glutamic acid, 1% protein complex, 0.1% vitamin C, 0.05% phytosterols, the lemon flavoring 0.5%, and the sweetener of 1.5% (0.05% acetylcholine potassium, 0.05% sodium cyclamate, 0.05% sodium saccharin). Thoroughly homogenized, bring the volume of purified water to 100%, the resulting solution was re-mix thoroughly, pass the mixture through a homogenizer under high pressure, filtered and poured into containers.

Comparison of the effectiveness of restorative actions were conducted during the epidemic ARI (acute respiratory viral infections).

Created two groups of 15 people each. The subjects of the first group took the claimed composition according to example 4, at a dosage of 11 ml (1 vial) 1 times a day for 2 weeks, and the subjects of the second group is composed of prototype 2 week 1 time per day is equivalent to the volume within 2 weeks. Number of patients (cases of SARS) in the first group consisted of 9 people, in the second 15.

To confirm the antidepressant activity of the composition was tested on EXT is ovalized with induced excessive stress loads, with sleep disorders who are experiencing depression and other disorders and heavy physical activity. When testing the proposed structure showed high efficiency.

The experiment involved 20 people. 10 of them the drug in the dosage - 11 ml (1 vial) at night for 7 days, 10 - on a similar scheme took the drug prototype equivalent amount within 7 days to the night.

Surveillance of patients allowed us to assess the clinical efficacy of the composition. Conducted biochemical blood tests, urine analysis, ECG. The resulting data and patient surveys, you can make the following conclusions: all patients reported good tolerability, adverse effects were not observed; patients reported overall improvement, normalization of sleep and improve bowel function.

Example 1

Patient P., 38 years old, with a diagnosis of neurotic depression and weakening after viral diseases that are assigned to the course (7 days) in 11 ml (1 vial) at night. After the course the use of the substance, the patient noted significant improvement in mood, reducing lethargy, lethargy, lack of initiative; normalized sleep and appetite.

Example 2

Patient C., 29 years old, with a diagnosis of endogenous depression, fatigue was appointed course of the composition of the invention p is 11 ml (1 vial) at night within 7 days. After the course of the drug, the patient showed complete normalization of mood, sleep, disappeared ideas of guilt inherent in the patient when applying for admission. Normalization of physical activity on day 3 of admission composition.

Based on the results of studies of the proposed structure exhibits pronounced:

- the antidepressant effect, improves mood and emotional tone;

- stimulates the nervous system and improves blood flow to the brain, heart and other organs;

- helps to overcome stress and increases the body's resistance to adverse environmental factors.

Identified the following indications for use:

- depression - mild and moderate forms;

- mental and physical overload;

- chronic fatigue syndrome;

- stimulation of mental activity;

- prevention and treatment of early forms of hypertension;

- rehabilitation after operations, injuries, long-term chronic diseases;

- protection from exposure to adverse environmental factors, especially in zones of ecological disaster.

The composition having tonic, tonic and antidepressant action, contains ginseng root extract, citric acid, taurine, guarana extract, sweetener, preservative, fragrance is the jam and water, characterized in that it further comprises L-glutamine, extract of Siberian ginseng, Royal jelly, extract roots with rhizomes of licorice, zinc gluconate, fructose, with the following ratio of ingredients, wt.%:

L-glutamineof 0.1 to 25.0
extract of Siberian ginsengof 0.1 to 15.0
Royal jelly0,1-10,0
taurine0,1-10,0
guarana0.5 to 10.0
extract of ginseng root0,1-5,0
extract of roots with rhizomes of licorice0,05-5,0
zinc gluconate0,05-1,5
fructose1,0-10,0
citric acid0,05-2,0
preservative0,01-1,0
sweetenerof 0.001 to 1.5
flavor0,001-0,5
water100



 

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3 cl, 1 tbl, 5 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, particularly to a composition for potassium channel regulation in a myocardial cell. The pharmaceutical composition for potassium channel regulation in a myocardial cell containing Ginseng in the form of ethanol extract, Ophiopogonis in the form of concentrated water infusion, Corni in the form of ethanol extract, Radix Salviae Miltiorrhizae in the form of ethanol extract, fried seeds Ziziphi spinosae in the form of concentrated water infusion, Taxilli in the form of concentrated water infusion, Rubra in the form of concentrated water infusion, Steleophaga, taken in certain amounts. The use of the pharmaceutical composition for preparing a drug for potassium channel regulation in a myocardial cell in treating supraventricular arrhythmia, ventricular tachycardia, ventricular flutter, ventricular fibrillation, premature atrial contractions, atrial tachycardia, atrial flutter or atrial fibrillation. A method for preparing the pharmaceutical composition.

EFFECT: composition effectively regulates potassium channels in a myocardial cell.

10 cl, 8 dwg, 5 ex

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