Method for cytoflavin electric accumulation in treating vascular and dystrophic retinal and visual nerve diseases

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely ophthalmology and physiotherapy, and may be used for treating vascular and dystrophic retinal and visual nerve diseases. That is ensured by the intravenous drop-by-drop infusion of the 2/3 amount of the medical solution made of cytoflavin 10 ml and 0.9% sodium chloride 200 ml. It is followed by 15-minite transverse halvanisation in the Potok-1 apparatus at current force making 0.5 mA. For this purpose 2 oval anode electrodes through a pad impregnated in distilled water are placed on skin of closed eyelids of both eyes and connected by a Y-wire with the anode of the apparatus. The third cathode electrode is placed transversally in relation to the two first anode electrodes on the area of upper cervical spines S2-S4 and connected with the cathode of the apparatus. The therapeutic course makes 10 daily procedures.

EFFECT: method provides high clinical effectiveness ensured by high functional effectiveness of cytoflavin electric accumulation in eye tissue with improving visual acuity by 0,15-0,3, prolonged action of the ensured therapeutic effect up to 5-6 months, eliminated risk of damaging an external eyeball capsule.

1 tbl, 2 ex

 

The invention relates to medicine, in particular to ophthalmology, physiotherapy, and can be used in the treatment of pathology visually-nervous apparatus of the eye.

The main method of treatment of vascular and degenerative diseases of the retina and optic nerve is a complex system and local pharmacotherapy, including, typically, a set of multiple drugs of different pharmacological groups: improves capillary perfusion of the nerve tissue, the offsets of energy metabolism, antihypoxants and antioxidants (Krasnogorsk). Abstract of "integrated System of treatment of degenerative diseases of the retina", Krasnoyarsk, 2008).

However, any injection method of administration of drugs, systemic, local, medicines, first of all, go into the General bloodstream, which bind plasma proteins and erythrocytes. Penetration into the tissue of the eye formed of high-molecular compounds largely prevents gematologicheskii barrier (y) and, accordingly, the treatment effect is clearly insufficient. In addition, a daily serial invasive introduction of at least 3-4 drugs: intravenous, intramuscular periocular causes the patient for a long psycho-emotional stress, which in turn forms the t high risk of adverse reactions and complications, for example, increased blood pressure, cardiovascular decompensation, exacerbation of chronic diseases. In addition, local periocular introduction of medicines associated in the injection zone to the danger of penetrating injuries of the outer capsule of the eye, representing a real threat of vision loss.

In recent years, to reduce the emotional burden on the patient's body and optimization of therapeutic possibilities tactics of treatment of vascular and degenerative diseases of any localization of practical interest-official multicomponent pharmacological solutions with polyfunctional orientation, containing from 2 to 4 compatible drugs that showed its electoral therapeutic efficacy in their stand-alone application, such as milgamma, Mexidol, cytoflavin. However, due to the presence of GOB for injectable way of introducing the multicomponent dosage solutions also not achieved therapeutic concentration of the ingredients in eye tissues necessary to restore and maintain the viability of the neurons of the retina and optic nerve.

With the aim of increasing the permeability of the GOB for drugs ophthalmologists widely used methods of pharmacophores - introduction Lakers the governmental funds using various physical factors and first of all, DC.

In ophthalmology use different methods of electrophoresis: Bourguignon through closed eyelids, or vannochkovogo electrophoresis on Cantona with open eye (Intein, Aguave "Physical therapy of eye diseases. Simferopol. Tavria. 1998, S. 21-22).

However, these methods are intended for the treatment of diseases, mainly of the anterior eye and are ineffective in the pathology of the retina and optic nerve.

The analog prototype of the invention is a method endonasal electrophoresis on Aphrodence - Iscussio - "occipital" method (Intein, Aguave "Physical therapy of eye diseases. Simferopol. Tavria. 1998, S. 9-11).

While cotton or gauze pads moistened with a solution of a medicinal substance, such as cytoflavin injected into both nasal progress to a depth of 1-2 cm at the ends of Turunc placed on the oilcloth 2×5 cm, located on the skin above the upper lip. On the free ends of the pads impose electrode and connected to one of the poles. The second electrode is placed in the neck and connected with the other pole.

The disadvantages of the method on the prototype:

- inadequate therapeutic efficacy as a medicinal substance comes first in the blood, and then only in the tissue of the retina, optic nerve, which enters only 2-5% (Vgenerally. "ELEH tritherapy". Moscow. "Medicine". 1987, S. 39) from the total amount of drug used in the procedure, a large portion is deposited in other organs and systems;

- inactivation of components of the medicinal solution products of electrolysis.

The objective is to propose a method of increasing the effectiveness of medical rehabilitation of patients with vascular and degenerative diseases of the retina and optic nerve.

The technical result - improving the efficiency of pathogenetic therapy in patients with vascular and degenerative diseases of the retina and optic nerve by electromodulation in the nervous tissue of the eye multicomponent drugs. For example, the composition of the multicomponent dosage solution - cytoflavin - includes: inosine, nicotinamide, Riboflavin - mononucleotide, succinic acid, the combination of these ingredients improves capillary perfusion and processes of oxygen utilization by the tissues, stimulates respiration and energy formation in the cells, the activity of antioxidant enzymes (VFS. Cytoflavin in intensive care. St. Petersburg, 2005).

The technical result is achieved by the fact that after the intravenous drip infusion 2/3 the volume of drug solution made from 10 ml of cytoflavin and 200 ml of 0.9% solution of sodium chloride, conduct Popper is know galvanizing apparatus "Thread-1". 2 electrode - anode oval shape of the eye through a pad moistened with distilled water, placed on the skin closed eyelids of both eyes and connect the forked wire - anode of the device, thus take into account the negative polarity of all components of cytoflavin medicinal components. 3rd electrode-cathode include a transversely with respect to the first two in the region of the upper cervical vertebrae (S2-S4) and is connected to a cathode. Current is 0.5 mA, duration of exposure 15 minutes, in the course of treatment prescribed 10 procedures carried out daily.

The advantage of the proposed method:

- high functional efficiency cytoflavin-electromodulation in patients with vascular and degenerative diseases of the retina and optic nerve with improvement of visual acuity in the 0.15-0.3;

the prolongation of the duration of the achieved therapeutic effect of up to 5 - 6 months due to electromodulation medicinal substances, as directed movement of negative ions all components of cytoflavin in the direction of the anode electrodes fixed in the field of both eyes, increases the excretion of the drug from the General flow, and it electromodulated in the eye tissues;

- there is no need for daily repetition, invasive procedures for the introduction of farmakologicheskaya, included in the standard treatment regimen;

- eliminates inactivation of drugs included in cytoflavin, products of electrolysis, as a medicinal substance is injected intravenously, and electrophoretic not;

- during the procedure, there is no risk of damage to the outer capsule of the eyeball, so as a way of introducing non-invasive.

The results of the application of cytoflavin-electromodulation in the treatment of vascular and degenerative diseases of the retina and optic nerve are shown in table 1.

Analysis of the obtained data has shown that the application of cytoflavin-electromodulation visual acuity after treatment has increased against the source of almost 1.6 times, while at endonasal cytoflavin-electrophoresis only 1.3 times; duration of therapeutic effect, respectively, increased by 2-3 months.

Example 1. Patient S., 59 years old. Clinical diagnosis: chronic ischemic neuroarthropathy both eyes. From the anamnesis: sick for 1.5 years, during this time twice received outpatient treatment: intravenous antioxidant solcoseryl in/muscle to improve intraocular capillary perfusion piracetam, periocular - Cortexin. Visual acuity of the right eye at the beginning of the disease was equal to 0.4, the left - 0,3 after courses of pharmacotherapy increased the ü to 0.5 in both eyes, however, after 2-3 months to return to baseline. To improve the efficiency of medical rehabilitation the patient in the physiotherapy Department was appointed cytoflavin-electromodulated: after intravenous drip infusion 2/3 the volume of drug solution made from 10 ml of cytoflavin and 200 ml of 0.9% solution of sodium chloride, were cross galvanization: 2 electrode - anode connected to the apparatus "Thread-1", was placed on the skin closed eyelids, 3rd electrode - cathode disposed transversely in the region of the upper cervical vertebrae S2-S4. After 10 treatments, the visual acuity of the right eye improved to 0.6, the left - to 0.5. The achieved therapeutic effect was maintained during the 6 months of observation.

Example 2. Patient K. 67 entered on the treatment of progressive exudative age-related macular degeneration in both eyes. Visual acuity at admission of the right eye of 0.4, the left eye is 0.5. Assigned cytoflavin-electromodulated. After 10 treatments, the visual acuity was: right eye 0,6, left - to 0.7. The achieved therapeutic effect lasted 5 months.

Table 1
Nosological formn eyesCytoflavin-electroc the while accumulation n eyesEndonasal cytoflavin electrophoresis
Visual acuityLength. the achieved effectVisual acuityLength. the achieved effect
ex.After the treatmentex.After the treatment
Age-related macular degeneration120,2-0,50,4-0,75-6 months80,2-0,50,3-0,52-3 months
Chronic ischemic neuroarthropathy1001-0,30,3-0,66 months90,25-0,50,3-0,53-4 months
Optic nerve atrophy90,15-0,40,3-0,5 5-6 months110,1-0,50,2-0,43 months

The way cytoflavin-electromodulation in the treatment of vascular and degenerative diseases of the retina and optic nerve, comprising the electrophoretic introduction of cytoflavin, characterized in that after the intravenous drip infusion 2/3 the volume of drug solution made from 10 ml of cytoflavin and 200 ml of 0.9% solution of sodium chloride, conduct cross-galvanizing apparatus "Thread-1", 2 electrode - anode oval through the pad moistened with distilled water, placed on the skin closed eyelids of both eyes, then connect the electrodes - the anode bifurcated wire from the anode of the device, while taking into account the negative polarity of all components of cytoflavin medicinal components, 3rd electrode - cathode include a transversely with respect to the two first electrodes - the anode in the region of the upper cervical vertebrae S2-S4 and is connected to a cathode of the device, and the current is 0.5 mA, duration of exposure 15 min, in the course of treatment prescribed 10 procedures carried out daily.



 

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2 cl, 3 tbl, 1 ex

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2 cl, 1 ex, 2 dwg

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7 cl, 2 dwg

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