Method for prediction of clinical course of diabetes mellitus

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely endocrinology and diabetology. The clinical course of diabetes mellitus is predicted by evaluating the following risk factors: tongue rolling, myopia, jug ears, joint hypermobility, platypodia, astenic body, diagonal fold of the earlobe, high skin elasticity, varicosity, visceroptosia, height/span > 1.1, clinodactyly, mitral valve prolapse, renal cysts, Gothic palate, chest distortion, biliary tract deformation, arachnodactylia, false left-ventricular chordas. If the patients suffering type 1 diabetes mellitus shows 5 or more indicators, a high risk of developing diabetic nephropathy and arterial hypertension is predicted. If the patients suffering type 2 diabetes mellitus shows 5 or more indicators, a high risk of developing ischemic cardiac disease is predicted. If observing 4 or less indicators in the patients suffering types 1 and 2 diabetes mellitus, a minimum risk of the unfavourable clinical course of diabetes mellitus is predicted.

EFFECT: method enables predicting the clinical course of diabetes mellitus in the patients with types 1 and 2 diabetes mellitus on the basis of the indicators of increased dysplastic stigmation.

3 ex

 

The invention relates to medicine, namely to endocrinology and diabetology, and can be used to predict the course of disease with high risk of early development of vascular complications in patients with diabetes mellitus type 1 and 2.

A known method for predicting microvascular complications, diabetic nephropathy, including the identification of prognostic risk factors such as diastolic blood pressure, the initial value of the ratio systolicdiastolic velocities (Vmax/Vmin) in the arc of the renal arteries, the level of glycated hemoglobin, triglycerides serum, conducting discriminant analysis and forecasting of development of diabetic nephropathy during the year (U.S. Pat. No. 2200328. RF: MCI 7 G01N 33/72, 33/92).

There is a method of predicting the course of diabetes mellitus type 1 (U.S. Pat. No. 2320272, EN, CL AV 10/00), taken as a prototype, namely, that establish the prognostic risk factors: age, level of antioxidant activity, total lipids, the concentration of diene conjugates, then the prognostic value of factors determine the formulas and predict the development of microvascular complications, the appropriate duration of disease.

The disadvantages of this method include low accuracy is ü forecast and the possibility of its use for prediction only in patients with type 1 DM, while the possibility of predicting the course of type 2 diabetes is not evaluated.

Objective of the claimed invention is to improve the accuracy and functionality by predicting the course of diabetes mellitus type 1 and 2.

The problem is solved because, according to the method of predicting the course of diabetes, including the establishment of risk factors as risk factors use characteristics: the ability to roll the tongue into a tube, myopia, protruding auricles, hypermobility of joints, flat feet, asthenic Constitution, diagonal crease in the ear lobe, increased elasticity of the skin, varicose augmented veins, visceroptosis, the ratio of height/reach >1,1, clinodactyly, mitral valve prolapse, renal cysts, Gothic sky, thorax deformation, deformation of the biliary tract, arachnodactyly, false left ventricular chord, and in the presence patient with diabetes mellitus type 1 5 or more characteristics predict a high risk of developing diabetic nephropathy and hypertension in a patient with diabetes mellitus type 2 with 5 or more characteristics predict a high risk of developing coronary heart disease, and in the presence of 4 and less than signs in patients with diabetes mellitus type 1 and 2 predict minimal risk adverse the CSO course of diabetes mellitus.

Advantages of the method are to increase forecast accuracy, and the method allows the prognosis for patients with diabetes mellitus type 1 and type 2. Furthermore, the method is easy to use, requires no special equipment.

The claimed invention is as follows.

1. The patient with diabetes carry out clinical examination and establish the risk factors on the basis of the assessment: the ability to roll the tongue into a tube, protruding auricles, diagonal crease in the ear lobe, Gothic sky, asthenic Constitution, increased skin elasticity (height, skin fold above the collarbone greater than 2 cm), the deformation of the chest, arachnodactyly, hypermobility of joints (on a scale Beighton'n) [Inherited disorders of connective tissue. Russian recommendations GFCF/ Avessi [and other] // Functional diagnostics. - 2009. No. 3. - Pp.61-87], flatfoot, clinodactyly, varicose veins, conduct anthropometry and determine the ratio height/reach>1,1. Then, on the basis of isometrie determine the presence of myopia. Then be held ultrasound of internal organs, on the basis of which is determined by visceroptosis, cysts of the kidney, deformation of the biliary tract, mitral valve prolapse, additional left ventricular notochord.

In the presence of 5 or more when Nakov predict the early development of hypertension and diabetic nephropathy in patients with type 1 DM and the early development of coronary heart disease in patients with type 2 diabetes, and at 4 years and less than signs predict the minimum risk of adverse course of diabetes mellitus.

An example of a specific use.

Patient A. Diagnosis: diabetes mellitus type 1. Clinical examination of a patient. During the inspection noted: asthenic Constitution, arachnodactyly, hypermobility of joints (9 points on a scale Beighton'n), increased skin extensibility (height, skin fold above the collarbone 2.5 cm), the ability to roll the tongue into a tube, protruding auricles, the ratio of height/reach=1,2, according to the U.S. internal organs: visceroptosis, mitral valve prolapse with regurgitation. Thus, identified 9 hypersensitive dysplastic stigmatise, so the patient is at increased risk for development of diabetic nephropathy and hypertension. Upon further observation for 3 years in a patient diagnosed with diabetic nephropathy in the phase of microalbuminuria and hypertension.

Patient B. Diagnosis: diabetes mellitus type 2. Clinical examination of a patient. During the inspection noted: the ability to roll the tongue into a tube, diagonal earlobe crease, flat feet, clinodactyly, varicose veins. According to isometrie defined myopia of an average degree. According to the U.S. internal organs: the polycystic kidney disease. In affect, the, identified 7 characteristics increased the dysplastic stigmatise, so the patient is at increased risk for development of coronary heart disease. In the first year of monitoring the patient's happened acute myocardial infarction.

Patient C. Diagnosis: diabetes mellitus type 1. Clinical examination of a patient. During the inspection noted: diagonal earlobe crease. According to isometrie defined myopia of an average degree. Thus, identified 2 sign of increased dysplastic stigmatize, therefore, predict the minimum risk of adverse course of diabetes mellitus. During the period of observation, despite the poor level of control, the only recorded complication was diabetic sensorimotor polyneuropathy 1 degree.

A method for predicting the course of diabetes, including the establishment of risk factors, characterized in that as risk factors use characteristics: the ability to roll the tongue into a tube, myopia, protruding auricles, hypermobility of joints, flat feet, asthenic Constitution, diagonal crease in the ear lobe, increased elasticity of the skin, varicose veins, visceroptosis, the ratio of height/reach >1,1, clinodactyly, mitral valve prolapse, renal cysts, Gothic sky, deformation width of chest, spring deformation of the biliary tract, arachnodactyly, false left ventricular chord, and in the presence of the patient with diabetes mellitus type 1 5 or more characteristics predict a high risk of developing diabetic nephropathy and hypertension in a patient with diabetes mellitus type 2 with 5 or more characteristics predict a high risk of developing coronary heart disease, and in the presence of 4 and less than signs in patients with diabetes mellitus type 1 and 2 predict a minimal risk of adverse course of diabetes mellitus.



 

Same patents:

FIELD: medicine.

SUBSTANCE: invention relates to medicine, particularly endocrinology and gynaecology. Diagnosing of hyperandrogenism syndrome in women of reproductive age is enabled by objective, laboratory and instrumental examintation. At the first stage, a combination of clinical manifestations in the patients are grouped. The second stage of the diagnosing involves the patients having clinical manifestations of hyperandrogenism if observing at least two indicators of the various clinical groups. At the second stage, the levels of prolactin, total testosterone, globulin-binding sex steroids (GBSS) are measured. It is followed by calculating a free androgen index (FAI) by formula FAI = total testosteron/GBSS × 100%. The third stage of diagnosing involves the patients with diagnosed hyperandrogenism syndrome on the basis of the level of total testosteron and/or FAI > 2%. At the third stage of diagnosing, blood lipid profile, immunoreactive insulin (IRI), blood glucose on an empty stomach are evaluated. The index HOMA=(glucose mole/l × IRI mcUnit/ml)/22.5 and the index Caro=glucose mole/l/IRI are calculated with detecting metabolic complications of hyperandrogenism syndrome.

EFFECT: method enables diagnosing hyperandrogenism syndrome in women of reproductive age.

3 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to pediatrics. In order to estimate level of bronchial asthma control in children analysis of night symptoms in patient and determination of characteristics of lung function are carried out. Frequency of night attacks, peak rate of exhalation in child, mother and father are evaluated. Additionally determined are: child's, mother's and father's age and height. Taken into account are: content of total Immunoglobulin E in child, child's chest circumference, age at the beginning of disease, duration of disease, duration of anti-inflammatory therapy, coefficient of gender identity, volume of performed anti-inflammatory therapy, treatment with inhalation glucocortocosteroids separately and together with inhalation long-acting β2-agonists, application of cromones, application of antileukotriene drugs, passive or active smoking, atopic dermatitis, allergic rhinitis, sensibilisation to household, epidermal and pollen allergens. Level of bronchial asthma control is estimated by value of coefficient obtained in application of discriminant analysis.

EFFECT: method makes it possible to increase accuracy of estimation of level of bronchial asthma control in children due to determination of lung function characteristics taking into account contribution of inheritance factor and time factor, volume of performed treatment, accompanying atopic diseases, spectrum of child's sensibilisation, individual anthropometric characteristics of child and their parents.

3 ex

FIELD: medicine.

SUBSTANCE: device for scull measurement relates to measuring instruments in field of medicine and can be used in anatomy, anthropology, forensic medicine, criminalistics for human scull study. Device contains mechanism of automatic object rotation, made in form of support disk with replaceable screw rests, which have possibility of correcting their height and position with respect to axis of rotation, which is brought into motion by stepper motor, unit of stepper motor control, ensuring automatic supply of preliminarily specified number of pulses corresponding to angular step of object rotation, laser rangefinder, ensuring measurement of distance to object surface, mechanism of vertical and horizontal travel of laser rangefinder.

EFFECT: mechanism of rotation and orientation with support disk and screw rests makes it possible to fix object in required position, stepper motor ensures automatic rotation of object around axis on 360° with specified angular step; mechanism of vertical and horizontal travel of laser rangefinder makes it possible to carry out layer-by-layer scanning of object surface with specified interval, as well as carry out measurements in separate points.

6 dwg

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to pediatrics, and can be used for selection of drug therapy of atherogenic dyslipidemia in children and teenagers with abdominal-visceral obesity. For this purpose index of body weight (IBW) is determined. By results of blood serum lipidogram calculation of atherogenity index (AI) is performed. If IBW is higher than 90-th percentile set for said age group, and AI level is from 2 to 4 including anthropometric parameter - sagittal diameter of abdomen (SDA) is additionally measured. If SDA index equals or is higher than 24.0 cm, state is estimated as requiring drug therapy with chophytol.

EFFECT: method ensures increase of drug therapy efficiency and reduction of risk of early development of atherosclerosis in said group of patients due to possibility of fast and objective determination of degree of expression of risk of early atherosclerosis development, individualisation of indications for drug therapy and its early administration.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to sports medicine, physiology, pediatrics and includes determination of examined person's height, functional parameters of their physical development: vital capacity of lungs and backbone strength, and morphologic parameters: body weight and chest girth in pause. Deviations of said parameters from proper values for examined person's height are determined by the correlation table taking into account examined person's sex and age. Difference between factual and proper parameters is divided by its particular sigma and ratio of sum of thus obtained values for functional parameters to sum of obtained values for morphologic parameters is determined. If this value constitutes from -2.0 to -1.1, physical development is determined as disharmonic, from -1.0 to +1.0 - as proportional, from +1.1 to +2.0 - as harmonic for present height of examined person.

EFFECT: method ensures accuracy of evaluation of examined person's physical development harmony at present moment of time taking into account impact if various factors.

2 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to combustiology, traumatology, resuscitation science and addictology, and can be used in treatment of patients with thermal burns, who are in state of alcohol intoxication. For this purpose determined are severity of burn disease, degree of alcohol intoxication, area of burn surface, physiological needs and pathologic loss during a day. After that volume of infusion therapy is calculated by formula: V=(Co × ABS)+(Ca x SVIT)+PN+PL, where V is volume of infusion therapy, in ml; Co is coefficient of burn disease severity: 0.5 in case of light burn shock; 0.75 in case of medium burn shock; 1.0 - in case of severe burn shock; 1.5 - in case of extremely severe burn shock. ABS is the area of burn surface, in cm2; Ca is coefficient of alcoholic intoxication degree: 0.5 - in case of light degree; 0.75 - in case of medium degree; 1.0 - in case of severe degree; 1.5 - in case of alcoholic coma. SVIT is standard volume of infusion therapy; PN stands for physiological needs of organism during a day, in ml; PL stands for pathologic loss during a day, in ml.

EFFECT: method makes it possible to ensure adequate carrying out of infusion therapy in all periods of burn disease in patients with different degree of alcoholic intoxication with simultaneous minimisation of hemostasis and microcirculation disorder, as well as makes it possible to ensure prevention of encephalopathy of complex genesis and alcoholic psychosis.

3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to resuscitation science and addictology, and can be used in carrying out detoxification-infusion therapy in patients in state of alcoholic intoxication. For this purpose determined are degree of alcoholic intoxication, body weight, physiological needs of organism and pathologic loss during day. Volume of detoxification-infusion therapy is calculated by formula: V=Ca × PW+PN+PL, where: V is volume of detoxification-infusion therapy, in ml; Ca is coefficient of alcoholic intoxication degree: 0.25 in case of light degree, 0.5 - in case of medium degree, 0.75 in case of severe degree, 1.0 - in case of alcoholic coma; PW is patient's body weight in grams; PN - physiological needs of organism during a day, in ml; PL - pathologic loss during a day, in ml.

EFFECT: method makes it possible to ensure carrying out adequate and efficient therapy in patients with various degree of alcoholic intoxication, with simultaneous minimisation of development of encephalopathy of complex genesis and alcoholic psychosis.

1 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to surgery and oncology. In order to predict relapse-free survival after liver resection in patients with metastases of colorectal cancer on the basis of combination of maximal size and quantity of metastases by the table "Clinical and pathological factors", included into the description, level of factor importance is determined and the number of points corresponding to the value of clinical-pathological factor is found. Obtained points are summed up, after which prognosis of relapse-free survival P(K) is determined by formula: where: K (Fi; d; m) is the function of Fi factor importance with specified values of d and m, where d is the maximal size of MTS, m is the number of MTS; n is the number of used factors, i is the index of summation. If P(K) equals 100-60 points, prognosis of relapse-free survival is bad, risk of relapse development is predicted within 12 months. In case of 59-30 points - prognosis is moderate, risk of relapse development - within 12-23.9 months. In case of 29-10 points prognosis is good, there is no risk of relapse development or it is predicted after 24 months.

EFFECT: method makes it possible to predict relapse of the disease after liver resection caused by metastatic colorectal cancer.

2 ex, 2 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to oncology. Diagnosis of a malignant growth requires conducting cytological preparation analysis by atomic force microscopy (AFM). The AFM involves measuring vertical dimensions of cell elements and regulating these dimensions. The characteristic functions of the regulated dimensions of the measured cell elements are evaluated. An affinity criterion of the evaluated characteristic functions to their reference values specified in accordance with any given disease, including malignancies is used to diagnose or exclude a malignant growth.

EFFECT: method provides higher diagnostic reliability in the malignant growth ensured by objectification of cytological data, higher measurement accuracy and reproducibility.

2 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely dentistry, and aims at describing a shape of the absent, destroyed and/or erased teeth. A width of a nose base is measured. The given value is used to determine a total width of six front teeth from an apex of one canine to an apex of the other canine. A number of face X-ray image is made. The X-ray image is rotated 180°. A face shape is used to describe a shape and a cutting edge of an incisor. A second incisor is described by means of mirror reflexion of the first incisor along a vertical line. A width of the second lateral incisor is determined by dividing the total face width on the X-ray image by a quotient of the width of the nose base by a width of a nasal septum. A canine width is restored by 80 % of the width of the second lateral incisor from front view. A lateral external shape of the canine is restored by describing a cheek contour found on the same half of the face, and upward limitation determining a tooth height is formed by an eyebrow being on the same side. For the purpose of teeth restoration on more developed side of the patient, determining a distance between a line passing through pupils and a line passing through angles of mouth is required.

EFFECT: method allows restoring the original shapes of the absent, destroyed and/or erased teeth due to analysing the patient's face.

9 cl, 8 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, in particular to pediatrics. When child is one month old, their somatic and neurological status is estimated and equation of regression is calculated: 42.423-4.373 ×No of group - 0.524 × sex - 0.972 × retardation of development of motor functions - 1.264 × intrauterine infection - 0.763 × allergic dermatitis- 1.212 × disembriogenesis stigmas + 1.807 × advancing development of communicative functions, where - No of group - 2 for group of children, who receive and No of group 3 for group of children who do not receive additional medical-corrective procedures; sex - 1 female, 2 - male; retardation of development of motor functions - 0 no, 1 present; intrauterine infection - 0 no, 1 present; allergic dermatitis - 0 no, 1 present; disembriogenesis stigmas - 0 no, 1 present; advancing development in communicative functions - 0 no, 1 present. Equation is calculated twice - for situation of application and absence of carrying out complex of medical-corrective procedures. Obtained values for both groups are compared and necessity of carrying out medical-psychological-pedagogical programme is determined.

EFFECT: method makes it possible to obtain objective estimation of age development of child and determine necessity of carrying out correction of their development.

2 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, in particular to endosurgery. In order to perform early diagnostics of acute pancreatitis after endoscopic transpapillary interventions, general clinical and physical examination, biochemical analysis of patients' blood are performed. In the course of post-operative examination "index of pancreatitis" (IP) is determined by formula: Hn=((Ap/An)x(PS1/PS0)×(L1/L0)×(PC+1))/4, where: Ap are values of patient's blood amylase; An are maximal values of blood amylase in norm; PS0 is average value of patient's pulse before endoscopic transpapillary interventions; PS1 is average value of pulse after endoscopic transpapillary interventions; L0 is number of blood leukocytes before endoscopic transpapillary interventions; L1 is number of blood leukocytes after endoscopic transpapillary interventions; PC is pain coefficient. Degree of pain syndrome expression is evaluated in points: 0 points - pain in abdomen is absent at rest and palpation; 1 point - pain in abdomen is present at palpation and is absent at rest; 2 points pain in abdomen is present at rest and increases at palpation; 3 points - together with pain syndrome, positive peritoneal symptoms are present. If IP≥ 1, acute postoperative pancreatitis is diagnosed.

EFFECT: method increases accuracy of early diagnostics of acute pancreatitis after endoscopic transpapillary interventions due to determination of totality of interconnected informative criteria such as value of amylase, value of pulse, number of leukocytes in blood, pain coefficient.

2 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine. In order to predict risk of development of occupational bronchopulmonary pathology, venous blood is sampled, genetic material is isolated, polymerase chain reaction is performed with specific primers, nucleotide sequence is determined and on the basis of this polymorphic versions of gene of matrix metalloproteinase 1 polymorphism 1607 delG are determined. In carrying out polymerase chain reaction specific primers MP1-F 138F BIOTIN - GCG TCA AGA CTG ATA TCT TAC TC A TAA ACA ATA and MP1-R 138R ACA TgT TAT gCC ACT TAg ATg Agg AAA are used. After carrying out polymerase chain reaction, reaction of pyrosequencing with application of specific primer MP1-S 138S gTA gTT AAA TAA TTA gAA Ag and detection of nucleotide sequence are performed. After that, comparison of obtained nucleotide sequence with reference sequences is carried out and obtained program is used to determine version of polymorphism 1607delG in nucleotide sequence, by which risk of development of occupational bronchopulmonary pathology is predicted.

EFFECT: method increases rate of carrying out prediction of risk of development of occupational bronchopulmonary pathology.

3 dwg, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to pediatrics. In order to estimate level of bronchial asthma control in children analysis of night symptoms in patient and determination of characteristics of lung function are carried out. Frequency of night attacks, peak rate of exhalation in child, mother and father are evaluated. Additionally determined are: child's, mother's and father's age and height. Taken into account are: content of total Immunoglobulin E in child, child's chest circumference, age at the beginning of disease, duration of disease, duration of anti-inflammatory therapy, coefficient of gender identity, volume of performed anti-inflammatory therapy, treatment with inhalation glucocortocosteroids separately and together with inhalation long-acting β2-agonists, application of cromones, application of antileukotriene drugs, passive or active smoking, atopic dermatitis, allergic rhinitis, sensibilisation to household, epidermal and pollen allergens. Level of bronchial asthma control is estimated by value of coefficient obtained in application of discriminant analysis.

EFFECT: method makes it possible to increase accuracy of estimation of level of bronchial asthma control in children due to determination of lung function characteristics taking into account contribution of inheritance factor and time factor, volume of performed treatment, accompanying atopic diseases, spectrum of child's sensibilisation, individual anthropometric characteristics of child and their parents.

3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to obstetrics and gynecology, and is intended for diagnostics of degree of chronic placental insufficiency severity. Degree of lack of correspondence of ultrasonic fetometry (US fetometry) data to gestation age of fetus is determined. Assessment if carried out by diagnostic CPI scale. Degree of blood flow impairment in uterine and umbilical arteries, integral parameter of fetus state (IPFS) and response of cardiovascular system of fetus (RCVSF) are evaluated. Each said parameter is given definite points depending on value. Calculation of final parameter is performed by summing up points given to said parameters. If value of final parameter in accordance with elaborated classification of CPI severity degree is from 1 to 3 points, I degree of CPI severity - dysfunction of placenta, is diagnosed; from 4 to 9 points - II degree of CPI severity - decompensated placental insufficiency; from 10 to 13 points - III degree of CPI severity - progressing decompensated placental insufficiency; from 14 points and higher - IV degree of CPI severity - critical placental insufficiency.

EFFECT: method is safe and non-invasive, makes it possible to increase accuracy of diagnostics of CPI severity degree due to standardisation of diagnostics process by application of elaborated clinical classification of said pregnancy complication, based on complex point scale of estimation of CPI severity degree.

3 ex

Catheter // 2457871

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, namely a catheter, particularly a catheter for collection of a number of samples inside a blood vessel along its length, and related methods, particularly a method for creating a data profile for one or more biomarkers recovered from a blood vessel wall, a method for profiling a length of the blood vessel for determination of the pathological or physiological state of the blood vessel wall, and a method for blood sampling in vivo from the blood vessel. A catheter comprises an elongated central body, at least one collection portion limited along the elongated central body for sample collection in the central portion of the blood vessel, and at least one mixer presented radially outside the elongated central body. Said body is introduced in the blood vessel and arranged along it. At least one mixer extends around said body circumferentially substantially in all radial directions. The mixer is presented to serve as an blood flow obstruction along the blood vessel to create a blood flow from a layer bordering the blood vessel wall along the whole periphery of the blood vessel in said body so that to enable said at least one collection portion collecting samples from the bordering layer.

EFFECT: invention provides improved better result consistency and closer correlation of the actual positions of biomarker sources and the positions in which such biomarkers are initially collected.

23 cl, 25 dwg, 1 tbl

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to otolaryngology, and deals with immunotherapy of purulent rhinosinusitis. Method is based on data of genotyping by signs of allele polymorphism of cytokine gene, obtained in analysis of blood cells and cells isolated from washings from sinuses. If high-producing allele of gene LL-β "2/2" and low-producing allele of gene TL-1RA "1/1" are identified in patient, immunotherapy with preparation of recombinant 1L-1RA, conditioned by regulation of activation of phagocytic activity of neutrophils, is performed.

EFFECT: method ensures efficient treatment of patients with lingering course of disease, who cannot be treated by traditional methods of therapy, due to individual selection of immunopreparation taking into account immunogenetic peculiarities of organism.

6 dwg, 4 ex

FIELD: medicine.

SUBSTANCE: invention relates to endocrinology, cardiology and therapy. In order to diagnose symptomatic arterial hypertension in patients with adrenal incidentalomas determined are: concentration of hormones in blood and their metabolites in urine, content of potassium and sodium, clinical symptoms of hormonal activity of tumour, age, sex, duration of observation, localisation and size of incidentaloma, index of body weight, characteristic of obesity, disorders of carbohydrate metabolism, trophic skin disorders, sexual disorders, neuromuscular syndrome, systolic and diastolic arterial pressure, heart rate, frequency of hypertonic crisis and its emotional tinge, affection of cardio-vascular system, eyes, kidneys, content of cholesterol, level of cortosol, coefficient of circadian rhythm of cortrisol production, concentration of aldosterone, index aldosterone/rennin, plasma rennin activity, presence of nicturia, content of catecholamines in urine, maximal specific weight of urine, day diuresis, presence of polypsia. If absolute error value obtained with application of multilayer perceptron is from 0 to 0.4999, symptomatic arterial hypertension of adrenal genesis is diagnosed. If absolute error value is larger or equals 0.5, essential arterial hypertension is diagnosed.

EFFECT: method makes it possible to diagnose symptomatic arterial hypertension in patients with adrenal incidentalomas.

2 ex, 4 tbl

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to traumatology and orthopedics. In order to carry out biological assessment of osteoinducing effect of blood plasma proteins modified autoplasm is obtained from human blood. Modified autoplasm is tested on three laboratory animals, which are preliminarily subjected to shin bone fracture, with further, 48 hours later, intraperitoneal introduction of modified autoplasm in volume 0.02 ml. After that, 72 hours after introduction of modified autoplasm, blood is sampled from said animals, with determination of alkali phosphotase activity in its serum. If alkali phosphotase activity in serum of at least two animals is twice or more times higher relative to upper boundary of norm, characteristic of selected animal species, conclusion about presence of osteoinducing effect of tested blood serum proteins is made. If alkali phosphotase activity increases two times and more relative to upper boundary of norm only in one animal, conclusion about absence of osteoinducing effect of tested blood serum proteins is made.

EFFECT: method makes it possible to assess osteoinducing effect of preparation of blood autoplasm proteins, used for stimulation of bone reparation in patients with delayed osteogenesis.

1 ex

FIELD: medicine.

SUBSTANCE: invention relaters to medicine, namely to oncology and surgery, and is intended for predicting outcome of treatment of patient with urinary bladder cancer. Determined are depth of tumour invasion into urinary bladder (a1), histologic type of urinary bladder cancer (a2), histopathologic gradation of urinary bladder cancer (a3), tumour sensitivity to PCT (a4), volume of performed treatment (a5), diseases of genitourinary system, leading to infravesical obstruction (a6), tumour localisation (a7). After that, prediction of distant results of urinary bladder cancer treatment is determined by formula: y = a0+a1x+a2x+a3x+a4x+a5x+a6x+a7x, where a0 (free member) = -1.35, a1 = 0.26, a2 = 0.13, a3 =0.22, a4 = 0.41, a5 = 0.37, a6 = 0.15, a7 = 0.06, x is numerical value, taken for certain patient and selected from table 1 given in description, depending on type and degree of parameters of prognostic factors (a1 - a7). Prediction is considered good if y lies within the interval 0-2.5, prediction is considered to ne satisfactory if the number is within the interval 2.6-3.5, prediction is considered to be doubtful if y value is within the interval 3.6-4.5, prediction is considered unsatisfactory if y value is larger than 4.6.

EFFECT: method makes it possible to determine prediction prospectively, optimise treatment tactics and form complex of measures of tertiary prevention.

2 tbl, 1 ex

FIELD: medicine, clinical toxicology.

SUBSTANCE: at patient's hospitalization one should gather the data of clinical and laboratory values: on the type of chemical substance, patient's age, data of clinical survey and laboratory values: body temperature, the presence or absence of dysphonia, oliguria being below 30 ml/h, hemoglobinuria, erythrocytic hemolysis, exotoxic shock, glucose level in blood, fibrinogen and creatinine concentration in blood serum, general bilirubin, prothrombin index (PTI), Ph-plasma, the state of blood clotting system. The state of every sign should be evaluated in points to be then summed up and at exceeding the sum of points being above "+20" one should predict unfavorable result. At the sum of "-13" prediction should be stated upon as favorable and at "-13" up to "+20" - prediction is considered to be doubtful.

EFFECT: higher accuracy of prediction.

2 ex, 3 tbl

Up!