Method for correction of disturbed structural-functional properties of red cells and immune status in patients suffering acute pancreatitis
SUBSTANCE: invention refers to medicine, namely surgery, and concerns correction of disturbed structural-functional properties of red cells and immune status in patients with acute pancreatitis. For this purpose a complex pharmacotherapy is added by the single intramuscular introduction of the preparation Longidase 3000 IU on the 3, 6, 9, 12 and 15 days; the intravenous drop infusion of the preparation hypoxene 2.0 g once a day for 7 days, by dissolving the content of ampoule ex tempore in 5% glucose 400 ml, and the intravenous slow introduction of Essentiale H 5.0 ml once a day for 10 days.
EFFECT: method provides clinical effectiveness ensured by intensified repair processes and anti-infectious body resistance.
1 ex, 1 dwg
The invention relates to medicine, in particular to surgery.
Acute pancreatitis remains the most severe purulent-septic diseases, which is the main reason for the development of sepsis syndrome and multiple organ failure. The successes of modern medicine gave surgeons a number of effective methods to save the lives of patients with acute pancreatitis. However, the number of postoperative complications the most severe forms of acute pancreatitis in the last decade remains at the level of 20-35% and has no tendency to further decrease. Existing at the present stage of differences in surgical tactics, antibiotic therapy does not have a significant impact on further reducing the number of extra - abdominal complications, and therefore improve treatment outcomes can only be achieved with a deep understanding of the pathogenetic mechanisms of the inflammatory process. Early diagnosis immunometabolic violations timely and targeted impact on the pathophysiological mechanisms of acute pancreatitis will prevent the development of serious complications requiring repeated surgical interventions. Because the immune and oxidative mechanisms and structural-functional properties of erythrocyte membranes is a mandatory element in the pathogenesis of FS is cnyh forms of acute pancreatitis, in modern conditions of successful treatment is impossible without taking into account the mechanisms of action of drugs on the immune and oxidative system of the patient. Moreover, the organization of the cytoplasmic membrane of cells, tissues and organs determines, to a large extent, the course of the disease. In this regard, for adequate pharmacokineti and increase the effectiveness of treatment requires the use of immunomodulatory, antioxidant and membraneactive funds.
Currently closest to the invention is a Method of treatment of acute pancreatitis with the use of the drug "Galavit (Immunotherapy with destructive pancreatitis. Methodological manual for doctors. / Usenik, Dwikardana, Overvue etc. - Krasnoyarsk, 2006. - 14 C.; Garipov, P.M. Acute destructive pancreatitis: immunological aspects in diagnosis and treatment. / Ramgarhia, Sargysan. // Medical journal of Bashkortostan. - 2010. - V.5, №4. - P.55-60).
However, the prototype has several disadvantages: despite the description of the importance of immune disorders in the pathogenesis of acute pancreatitis, the authors recommend the use of immunokorrigiruyuschuyu therapy using the drug "Galavit", the drug "Galavit has mainly immunokorrigiruyuschy (immunomodulatory) effects, whereas unattended AB the Directors, there remains the problem of adhesive obstruction, one of the most frequent and severe complications in the treatment of destructive forms of acute pancreatitis pathogenesis which plays a key role in the immune homeostasis and in the first place - macrophage level of anti-infective protection; status of lipid peroxidation and the organization of the cytoplasmic membrane of the cells of organs and tissues, which play an important role in the pathogenesis of immunological disorders.
The technical result of the invention is to correct the structural and functional properties of erythrocytes and immune and oxidative disorders, reduced treatment time, reduced incidence of complications and improve the quality of life of patients with acute pancreatitis.
The technical result is achieved by the fact that in addition to the integrated pharmacotherapy for the treatment of patients with acute pancreatitis, regardless of the severity of the condition is used pharmacological method of influence: the drug, "Longdata", which in addition to the N-oxide-poly-1,4-ethyleneimine possessing immunomodulatory (immunokorrigiruyuschy) properties, is conjugate hyaluronidase (lydasum)with proteolytic enzyme (hyaluronidase) activity prolonged action and anti-inflammatory properties, which introduced ME 3000 intramuscularly once at 3, 6, 9, 12 and 15 days; "lipoxen", with antioxidant (antihypoxant) activity, injected 2.0-1 g once a day for 7 days intravenously by drip infusion, the contents of the ampoule ex tempore dissolved in 400 ml of 5% glucose solution; "Essentiale N"with membraneactive activity, introduce 5.0 ml intravenously slowly 1 time a day for 10 days.
The invention is illustrated in the following drawing: the dynamics of representative proteins of the membrane of red blood cells: α - and β-spectrin, ankyrin, biotransport protein (ATB), the protein band 4.1, pallidin, protein bands 4.5, dematin, actin, glyceraldehyde-3-phosphate dehydrogenase (G-3-PD), tropomyosin, glutathione-S-transferase (G-S-T), the dynamics of the sorption properties of the membrane of red blood cells: the sorption ability of erythrocytes (SSE) and the sorption capacity of their glycocalyx (NEGP); cytokine status: α - primary mediator inflammation, which plays a significant role in coordinating the inflammatory response and cytokine cascade, IL-1β, which is the main mediator of the development of local inflammatory reactions, Ostrovskogo response at the level of the organism, capable of launching products about 100 cytokines, IL-6 is an important proinflammatory cytokine, IL-8 - the main chemotactic factor for neutrophils peripheral blood, IL-10 and IL-4, anti-inflammatory cytokines; Akti the activity of the complement system: the level of C 3and C4components of the complement system; indicators of functional activity of neutrophils of peripheral blood phagocytic index (PI), phagocytic number (FC), NBT-test spontaneous and stimulated simhasanam (nst-br, Nst-Art.); products of lipid peroxidation: malondialdehyde (MDA) and acylhydrazines (AGP) and catalase activity in patients who received the treatment developed by the scheme (in the drawing indicated by the dashed line) and treated traditionally (in the drawing, a solid line) based on indicators of healthy donors (which in the drawing is the radius of the circle), indicating significant differences (p<0,05) group treated with the scheme developed in relation to the group treated traditionally (in the drawing indicated by white circles).
Developed a method of treatment of patients with acute pancreatitis by using the application in complex treatment of pharmacological methods of influence: "Longdata", "Lipoxin and Essentiale N" - combination immunomodulator, antioxidant and membranoprotector, which significantly reduce the rate of level α spectrin, pallidin, IL-6, C3C4components of the complement system, indicators of functional-metabolic activity of neutrophils, malondialdehyde and catalase activity, is all this leads to increased anti-infective resistance of the organism, has membraneactive properties, anti-inflammatory and regenerative properties, enhances the reparative regeneration processes.
The method is as follows.
After establishing the clinical diagnosis of the patient as part of an integrated pharmacotherapy impose additional 3000 ME "Longdata" intramuscularly once at 3, 6, 9, 12 and 15 days; 2.0 g "Lipoxen" 1 times a day for 7 days intravenously by drip infusion, the contents of the ampoule ex tempore dissolved in 400 ml of 5% glucose solution and 5.0 ml "Essentiale N" slow intravenous 1 time a day for 10 days.
For comparison of treatment results for the proposed methods were applied therapy group patients with acute pancreatitis according to the traditional conventional methods.
Conducted traditional treatment in patients with acute pancreatitis allow 10-14 days to stop pain, bloating, 14 to 15 days, on physical examination, the presence of parapancreatic infiltrate, and ultrasound signs of acute pancreatitis, in addition, to prevent the development of septic complications in 60% of cases, which indicates a lack of clinical efficacy of traditional treatment regimens.
The proposed treatment regimen was more effective, because its use has reduced the duration of subjective symptoms is about 7 days, the presence of pancreatic infiltrate an objective examination and ultrasound signs of acute pancreatitis - up to 10 days, to reduce the number of purulent complications up to 25%, thus, prevent their development in 75% of patients.
Identified subjective and clinical data were confirmed by immunological indicators and oxidative profile and condition of the structural and functional properties of red blood cells in patients with acute pancreatitis under the influence of treatment. It is established that in the process of traditional treatment normalized only NEGP, level G-S-T, protein bands 4.5, G-3-PD, the remaining indicators are significantly different from the indicators of healthy donors.
When treatment is given by the developed technique with the inclusion of drugs "Longdata", "Lipoxin and Essentiale N" normalizes all the indicators of the functional activity of neutrophils peripheral blood, also noted a pronounced anti-inflammatory effect of pharmacological scheme, because its use reduces the levels α, IL-1β, IL-8, normalizes the concentration of IL-6 and increases the level of IL-10 and expressed membraneactive effect, because it reduces the representativeness of dematin, actin, pallidin and α-actin (drawing).
Clinical example. Patient S., 41, was admitted to the surgical Department of the MUSES "city clinical hospital №4" , Kursk 15.06.09 with a diagnosis of strainenergy pancreatitis. From history: acutely ill, about 7 hours ago. Hospitalized in MUSES "city clinical hospital №4" gburski.
A comprehensive survey:
OAK: er. 4,8×1012/l b 161 g/l, the CPU 1,0, LC 8,8×109/l, P-3, p-72, e-2, LF-21, Mon-2, the sedimentation rate of 5 mm/h
OAM: quantity - 50 ml, color - yellow, transparent, reaction - neutral density - 1010 g/l, protein - 0,165 g/l, epithelium - flat 3-4 in p/C, leukocyte - 1-3 p/C, R - 2-3 p/C. Diastasis 1024 g/h × L.
Ultrasonography. Liver steatosis, biliary hypertension no, ha exoneration. Mud 25×27×26 mm, heterogeneous, uneven contour. The main pancreatic duct is not lazerette.
Conclusion: swelling of the pancreas.
The patient was conducted intensive conservative therapy: infusion with antispasmodics, analgesics, antifermentny drugs, antibiotic therapy, immunostimulirutuyu therapy drug "Longdata", antioxidant therapy "Lipoxen" and membraneactive therapy drug "Essentiale N".
Dynamic ultrasound monitoring in a month have signs of chronic pancreatitis exacerbation.
Thus, the combined use of drugs "Longdata", "Lipoxin and Essentiale N" in the adjuvant pharmacotherapy in patients with acute pancreatitis at the same time corrects disorders of the immune status of lipid peroxidation and structural-is unctionally properties of red blood cells and significantly reduces clinical manifestations, shown in the treatment of patients with acute pancreatitis. Consequently, in the treatment of patients with acute pancreatitis has high therapeutic effect, reduced the rate of complications, which improves their quality of life.
Method of correction of violations of the structural and functional properties of erythrocytes and immune status in patients with acute pancreatitis, characterized in that the patient in complex pharmacotherapy impose additional 3000 ME "Longdata" intramuscularly once at 3, 6, 9, 12 and 15 days; 2,0, "Lipoxin" 1 times a day for 7 days intravenously by drip infusion, the contents of the ampoule ex tempore dissolved in 400 ml of 5% glucose solution and 5.0 ml "Essentiale N" slow intravenous 1 time a day for 10 days.
FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to new benzimidazole derivatives of general formula (I) or to its pharmacologically acceptable salts wherein R1 represents a C6-aryl group which can be substituted by 1-3 groups optionally specified in a group of substitutes (a), or a heterocyclic group which represents pyridyl, dihydrobenzofuranyl, 1,3-benzodioxolyl, tetrahydropyranyl, tetrahydrofuranyl which can be substituted by 1-3 groups optionally specified in a group of substitutes (a), R2 represents a C1-C6 alkyl group, R3 represents a C6-aryl group which can be substituted by 1-2 groups optionally specified in a group of substitutes (a), Q represents a group represented by formula =CH-, or a nitrogen atom and a group of substitutes (a) represents a group consisting of a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a carboxyl group, a C2-C7 alkylcarbonyl group, a C2-C7 alkoxycarbonyl group, a C1-C6 alkoxy group, a C1-C6 halogenated alkoxy group, an amino group, a 4-morpholinyl group and a di-C1-C6 alkyl)amino group. Also, the invention refers to a pharmaceutical composition based on a compound of formula (I), to a PPARγ activator/modulator based on the compound of formula (I), to using the compound of formula (I), to a method of reducing blood glucose, to a method of activating PPARγ, a method of treating and/or preventing said pathological conditions.
EFFECT: there are produced new benzimidazole derivatives showing PPARγ modulatory activity.
41 cl, 2 dwg, 6 tbl, 76 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to new piperazine amide derivatives of formula wherein X represents N or CH; Y represents N or CH; R1 represents lower alkyl, phenyl, phenyl-lower alkyl wherein phenyl can be optionally substituted by 1-2 substitutes independently specified in a group consisting of halogen, lower alkyl; R2 represents lower alkyl, phenyl, naphthyl or heteroaryl specified in dimethylisoxazolyl, quinolinyl, thiophenyl or pyridinyl wherein phenyl or heteroaryl are optionally substituted by 1 substitute optionally specified in a group consisting of halogen, lower alkoxy group, fluor-lower alkyl, lower alkoxy-carbonyl and phenyl; R3 represents phenyl, pyridinyl or pyrazinyl wherein phenyl, pyridinyl or pyrazinyl are substituted by 1-2 substituted optionally specified in a group consisting of halogen, lower alkyl and fluor-lower alkyl; R4, R5, R6, R7, R8, R9, R10 and R11 independently represent hydrogen, as well as to their physiologically acceptable salts. These compounds are bound with LXR alpha and LXR beta, and are applicable as therapeutic agents for treatment and/or prevention of high lipid levels, high cholesterol levels, low HDL cholesterol, high LDL cholesterol, atherosclerotic diseases, diabetes, non insulin dependent diabetes mellitus, metabolic syndrome, dislipidemia, sepsis, inflammatory diseases, infectious diseases, skin diseases, colitis, pancreatitis, cholestasis, liver fibrosis, psoriasis, Alzheimer's disease, etc.
EFFECT: preparing new piperazine amide derivatives.
15 cl, 88 ex
SUBSTANCE: present invention relates to novel pyridine derivatives of formula (I), where R denotes a linear alkyl with 4-8 carbon atoms. The invention also relates to a pharmaceutical composition based on a compound of formula (I), use of the compound of formula (I), a method of preventing or treating diseases caused by Helicobacter pyroli bacteria and/or diseases associated with secretion of gastric juice, and a method of producing a pyridine derivative of formula (I).
EFFECT: novel pyridine derivatives of formula (I), having useful biological properties, are obtained.
9 cl, 2 dwg, 8 tbl, 16 ex
SUBSTANCE: invention refers to medicine and aims at treating chronic pancreatitis. It involves superselective femoral catheterisation of branches of celiac axis, gastroduodenal or splenic arteries according to Seldinger's procedure. It is followed by continuous fractional infusion of a medicated mixture. Solutions No.1 and 2 are introduced alternately every 6 hour. The daily volume is 1.0 l. The solution No.1 contains hydrocortisone suspension 5-2.5 mg, contrical (aprotinin) 60000 Units and heparin 10000 Units in 0.25% novocaine 500 ml. The solution No. 2 contains Ringer's solution and heparin 10000 Units in 500 ml. Duration of the continuous fractional infusion is 4-6 days.
EFFECT: method allows more efficient drug-induced therapy of chronic pancreatitis by intensive local drug action.
1 ex, 5 dwg
SUBSTANCE: invention relates to azabenzofuranyl compounds of formula I and salts thereof, where: Z1 denotes CR1, Z2 denotes N, Z3 denotes CR3, Z4 denotes CR4, R1, R3 and R4 are independently selected from H, halogen, CN, -(CR14R15)nC(=Y)OR11, - (CR14R15)nOR11, C1-C12 alkyl; W denotes or R5 and R6 are independently selected from H or C1-C12 alkyl; X1 is selected from R11, -OR11 and -S(O)2R11; if X1 denotes R11 or -OR11 from X1 and -R5 optionally taken together with a nitrogen atom with which they are bonded form a 4-6-member saturated or unsaturated ring containing 0-2 additional heteroatoms selected from O, S, where said ring is optionally substituted with one or more groups selected from oxo, -(CR19R20)nNR16R17, -(CR19R20)nOR16, (CR19R20)nS(O)2R16 and R21; X is selected from aryl, where said aryl is optionally substituted with one or more groups selected from halogen, CN, -Si(C1-C6alkyl), -(CR19R20)nOR16, -(CR19R20)nSR16, C1-C12alkyl; R11, R12 and R13 independently denote H, C1-C12alkyl, aryl, azetidine, pyrrolidinyl, piperidinyl, tetrahydropyranyl; R14 and R15 are independently selected from H or C1-C12 alkyl; n is independently selected from 0, 1; Y independently denotes O; where each of said alkyl, alkenyl, aryl and heteroaryl from R1, R2, R3, R4, R5, R6, X1, X2, R11, R12, R13, R14 and R15 is independently and optionally substituted with one or more groups independently selected from -(CR19R20)nC(=Y')OR16, -(CR19R20)nNR16R17, -(CR19R20)nOR16, -(CR19R20)nNR16C(=Y')R17, -(CR19R20)nNR16C(=Y')OR17, - (CR19R20)nNR17SO2R16 and R21; each R16, R17 independently denotes H, C1-C12 alkyl, C2-C8alkenyl, aryl, or pyridinyl, where said alkyl, alkenyl or aryl is optionally substituted with one or more groups selected from -OH; R19 and R20 are independently selected from H, C1-C12 alkyl; R21 denotes C1-C12 alkyl, aryl, imidazolyl, pyridinyl, pyrazolyl, pyrrolidinyl, 2-oxo-pyrrolidinyl, piperidinyl, or 2,2-dimethyl-1,3-dioxolanyl; each Y' independently denotes O. The invention also relates to specific compounds, a pharmaceutical composition based on the disclosed compounds, a method of inhibiting anomalous cell growth or a method of treating hyperproliferative disorders, inflammatory diseases and other diseases.
EFFECT: novel azabenzofuranyl derivatives which can be used in treating cancer and inflammatory diseases are obtained.
23 cl, 3 tbl, 34 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmacology and medicine, and represents a composition for treating and preventing a disorder related to digestive enzyme insufficiency, containing a set of coated particles; each said particle comprises a enteric-coated core wherein the core contains pancrelipase and the enteric coating contains 10-20 wt % of at least one enteric-coated polymer and 4-10 wt % of talc wherein said wt % are calculated from total weight of the coated particles and wherein the coated particles show pancrelipase enzymatic activity loss by no more than approximately 25% after 6 months of accelerated stability test.
EFFECT: invention provides enzyme activity stability.
47 cl, 14 ex, 35 tbl
SUBSTANCE: group of inventions relates to medicine and can be applied to prevent development of acute post-surgical pancreatitis with patients suffering from stomach cancer and cancer of gastroesophageal area; the octreotide-depo preparation is used for the above purpose; the preparation is administered 7 days before the planned surgical interference in the amount of 20 mg, intramuscularly in a single shot.
EFFECT: group of inventions reduces the exocrinous kinesis of pancreas and thereby reduces the risk of post-surgical pancreatitis development.
2 cl, 3 ex
SUBSTANCE: group of inventions is referred to the area of medicine and can be used for treatment of acute destructive pancreatitis. Dual-lumen PVC drain tube corresponding to the length of a standard gastro-duodenal probe. The drain tube ends up at the level of the Treitz's ligament. It additionally contains a hole in a small passage made at the level of the duodenal bulb area inlet. Drugs that contain pancreatic enzymes are administered in the duodenal bulb area by this drain tube.
EFFECT: reduction of dependence on sandostatin-based drugs, improved treatment effectiveness.
2 cl, 1 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to pharmaceutics and medicine, and concerns a pancreas protector which contains a combination of a blood glucose decreasing drug not stimulating insulin secretion and a compound presented by formula (1), where the compound of formula (1) represents 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzonitrile or 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile exhibiting higher efficacy.
EFFECT: improved efficacy of the preparation.
15 cl, 4 tbl, 4 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to novel derivatives of pyridine, of general formula I, where R represents hydroxyalkyl group with normal non-branched chain, which has 5-10 carbon atoms or its pharmaceutically acceptable salt. Also, invention relates to method of obtaining compound of formula I, pharmaceutical composition based on formula I compound, as well as preventive and therapeutic anti-Helicobacter pylori medicine based on formula I compound.
EFFECT: obtained is novel pyridine derivative, which has anti-Helicobacter pylori activity.
24 cl, 4 tbl, 9 ex
SUBSTANCE: invention relates to medicine, namely to ophthalmology and is intended for treatment of optic nerve atrophy of vascular genesis. For this purpose pterygopalatine (PP) and submustoidal (SM) blockades are performed to patient with application of medicinal mixture, 7-9 blockades per course with time interval 22-24 hours. After that, discrete plasmapheresis in amount 3-5 procedures with time interval 48-72 hours is performed, with volume of exfusion for a procedure constituting 20-25% of circulating blood volume. Then extracorporal pharmacotherapy is carried out. Activation of cell mass, obtained in carrying out plasmapheresis, is performed with gliatilin in dose 500-1000 mg, with further reinfusion of activated cell mass intravenously, by drip infusion. To perform PP medicinal mixture, containing lidocaine 50-100 mg, gliatilin 250-500 mg, lidase 16-32 U, is used. To perform SM medicinal mixture, containing lidocaine 50-100 mg, cortexin 5-10 mg, lidase 16-32 U, is used.
EFFECT: invention ensures efficient treatment of disease with reduction of labour-consumption and simplification of method.
2 cl, 3 ex
SUBSTANCE: bioactive cationic polymer latex contains a latex polymer, at least one bioactive component at least partially encapsulated by a latex polymer and, optionally, at least one volumetric component contained in the latex polymer. The latex is obtained through emulsion polymerisation of monomers to form polymer latex in the presence of at least one bioactive component. The latex is a product of polymerisation of at least a first ethylenically unsaturated monomer and at least a second ethylenically unsaturated monomer, which is cationic or a cation precursor. The bioactive component used can be antibacterial and antifungal agents. The invention also describes methods of obtaining and using bioactive cationic polymer latex.
EFFECT: higher antimicrobial activity of latex and antimicrobial activity of products made from said latex.
43 cl, 4 dwg, 2 tbl, 3 ex
FIELD: biology and medicine.
SUBSTANCE: invention relates to the method of improving stem cells mobilization; the essence of the invention lies in the application of hyaluronidase immobilized on the basis of low-molecular polyethyleneglycol 1500 Da by a flux of running electrons at the voltage of 2.5 MeV as a medium herewith strengthening the stem cells mobilization.
EFFECT: improved stem cells mobilization.
5 ex, 5 tbl
SUBSTANCE: the invention relates to medicine, in particular, to haematology, and can be used for stimulation of myelogenesis. Pegylated hyaluronidase is administered with the dosage of 50 action units/kg 1 time a day for two days, additionally a medication containing D-glucuronic acid is intravenously administered once with the dosage of 2 mg/kg.
EFFECT: accelerated regenerative processes of haemopoietic tissues with additional administration of low doses of D-glucuronic acid, caused by its regulatory influence on hyaluronic acid metabolism of blood-forming precursors.
3 tbl, 1 ex, 1 dwg
SUBSTANCE: invention refers to medicine, namely to urology and andrology, and can be used for treating autoimmune male sterility. The method involves intramuscular injections of Longidase 3000 IU twice a week for 3 months.
EFFECT: use of the invention enables normalising ejaculate viscosity, increasing a number of A and B sperm cells, decreasing a number of pathological sperm cells, eliminating agglutination and agglomeration of sperm cells, normalising pH value ensured by lower concentration of antisperm antibodies on a sperm cell surface and in a sperm fluid.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of medicine, namely to surgery, traumatology, combustiology and dermatology and can be used for treatment and prevention of development of hypertrophic and keloidal scars. For this purpose lidase is introduced intradermally in therapeutic dose with its simultaneous transdermal introduction in average therapeutic dose. After that, after each procedure wet napkin, containing chitosan and collagenase with ratio 95:5, is applied on scar surface for 24 hours. Treatment course constitutes 10-15 daily procedures.
EFFECT: method ensures reduction of treatment and rehabilitation terms, normalisation of general state, as well as improvement of functional results due to increase of volume of movements in joints.
1 ex, 7 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: offered is the application of hyaluronidase immobilised by electron-beam synthesis nanotechnology as a hypoglycemic agent effective in non-insulin-dependent diabetes mellitus. The mechanism of action is supposed to be modification of the properties of hyaluronic acid of cell glycocalyx and receptors to insulin It is accompanied by higher ligand sensitivity.
EFFECT: in non-insulin-dependent hyperglycemia, immobilised hyaluronidase caused peripheral blood sugar level decreasing by 41,9 %; insulin concentration has been decreasing statistically significantly.
SUBSTANCE: invention relates to medicine, namely to addictology and deals with correction of pain syndrome in condition of opioid withdrawal. For this purpose in addition to standard therapy on the 1-st, 3-rd and 5-th day of treatment performed are injections of complex medication mixture with composition: lidocaine 80 mg, lidase 32 CU, ketorol 120 mg, dalargin 2 mg, 0.9% sodium chloride solution 2 ml subcutaneously to the depth from 1 to 2 cm into two points in backbone projection at level Th11-Th12 and L4-L5 on the middle of distance between spinous processes of adjacent vertebra in dose 5 ml with 48 hour interval.
EFFECT: method makes it possible to inhibit pain syndrome efficiently and quickly due to multi-level impact on general links of pathological algic system, as well as to reduce medication loading on organism.
1 tbl, 1 ex
SUBSTANCE: group of the inventions refers to medicine, namely to pharmacology, and concerns preparing new drugs for treating infectious and inflammatory diseases. An offered drug is presented in the form of a suppository or an ointment, and contains the following ingredients in said age-specific quantitative variations, g in a single dose: lisocyme - 0.05-0.15; methyluracyl - 0.025-0.1; vitamin A - 0.005-0.015; vitamin C - 0.015-0.02; vitamin E - 0.025-0.05; a fat base - 1.0-2.0. When treating infectious and inflammatory diseases, the offered drug is introduced two times a day every 12 hours. The length of treatment is 14-15 days.
EFFECT: involvement of the offered drug in a treatment regimen promotes increasing clinical effectiveness and reduced length of treatment due to its immunostimulating, antimicrobial and antioxidant actions.
2 cl, 4 tbl
SUBSTANCE: invention refers to medicine, namely to orthopaedics, arthrology, also can be used for treating coxarthrosis. That is ensured by ultrasound-aided introduction of a preparation of hyaluronic acid into the intraarticulate space of the hip joint. It is preceded with deep injections of Longidase in the annular ligament and attachment points of the hip joint muscles to the greater trochanter, and a session of manual therapy for the hip joint.
EFFECT: preliminary stage ensures higher elasticity and mobility of the muscular and copular system of the joint that allows bringing it in a convenient position for more precise introduction of the preparation of hyaluronic acid into the intraarticulate space.
11 cl, 3 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to new phospholipid curcumine complexes or to extracts containing it exhibiting improved bioavailability. The phospholipid curcumine complex or the extract containing it in which a phospholipid is a soya phospholipid and the phospholipid to parity to curcumine ratio is found within the certain range. A method for preparing the phospholipid complex. The phospholipid curcumine complex or the extract containing it prepared by the method described above. A pharmaceutical composition containing the phospholipid complex exhibiting chemoprophylactic activity. Using the phospholipid complex for preparing chemoprophylactic agents.
EFFECT: phospholipid complexes exhibit the improved bioavailability.
7 cl, 1 tbl, 4 ex