Dispersed glyoxal-processed cationogenic polygalactomannans

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a polygalactomannan composition, namely to a cationogenic guar gum composition which is cross-linked with glyoxal to form discrete guar gum particles easily water-dispersed that enables further guar gum processing such as washing.

EFFECT: composition may be applicable, eg as a personal hygiene product or household detergents, etc.

20 cl, 5 tbl, 14 ex

 

RELATED APPLICATIONS

In this application claims the priority of provisional U.S. application No. 60/856486, filed November 3, 2006, which in its entirety is included in the present invention by reference.

The technical FIELD TO WHICH the INVENTION RELATES.

The invention relates to polygalacturonase compositions, more specifically to compositions of the guar gum that when merging glyoxal form discrete particles of the guar gum, which can easily dispergirujutsja in water, which allows the subsequent processing of the guar gums, such as washing. Guar gum and its derivatives necessary for the application, for example, as a means of personal hygiene or household hygiene products, etc.

The LEVEL of TECHNOLOGY

Polygalacturonase and their derivatives are used in various fields, such as oil, personal care products, textile industry, paper industry, plating industry, food industry, etc. Polygalacturonase and their derivatives are difficult dispersing in aqueous solutions, as they tend to form sticky particles, which form clumps and agglomerates, which hinders the dissolution. To improve the dissolution of polymers using cross-linking reagents, such as borax, so that after the reaction of polygalacturonase it can b the lo rinse water and to improve the dispersibility of polygalacturonase in the water.

Described cross-linking reagents on the basis of borates, salts of aluminum, copper, iron, lead, calcium and sodium. Notes other cross-linking reagents, such as salts of metals containing titanium and zirconium, but without a clear definition of the methods or procedures for their application.

There are concerns associated with the use of boron compounds in some consumer products, and need an alternative cross-linking reagents for use in the cleaning and processing of polygalacturonases and their derivatives.

In personal care products, such as means for care of hair and skin, and household hygienic means, such as means for processing tissues, it is necessary deposition on a substrate coating formed without the use of boron-containing compounds. In the case of funds for care of hair coating reduces the energy required for combing hair in wet and dry condition, or gives the feeling of silkiness, softness of the skin or tissue. This coating can also improve the Shine and moisture retention in the hair and skin, and also to facilitate care for them and make them more pleasant to the touch.

SUMMARY of the INVENTION

The first object of the present invention is a method of obtaining polygalacturonase, which includes stages: obtaining cationogenic of polygalacturonase;knitting of polygalacturonase effective amount of glyoxal with obtaining crosslinked particles cationogenic of polygalacturonase. Then crosslinked particles cationogenic polygalacturonase dispersed in water having a pH in the range of below about 7 to about 3, and washed in water to remove impurities from stitched cationogenic particles polygalacturonase.

The second object of the present invention are compositions of personal care or household hygiene products, including custom made glyoxal cationogenic polygalacturonase and its derivatives. This stitched glyoxal cationogenic polygalacturonase applicable in various products, such as personal care products or household hygiene. Stitched glyoxal cationogenic polygalacturonase particularly useful for use in those cases when it is necessary to reduce or eliminate the use of boron-containing compounds.

BRIEF DESCRIPTION of DRAWINGS

Figure 1 shows the dependence of the viscosity of a 1% dispersion of the product of example 2 in distilled water from time to time at a pH of ?.

Figure 2 shows the dependence of the viscosity of a 1% dispersion of the product of example 3 in distilled water from time to time.

DETAILED description of the INVENTION

According to the invention it was found that processing cationogenic of polygalacturonase reaction mixture containing glyoxal, when the ratio of about 0.5 to 5.0 wt. parts glyoxal/1 wt. part of polygalacturonase riodic to despergiruemaya in the water polygalacturonase, which remains in the form of discrete particles and not aglomerated in the gel. The resulting product is easily washed with water and easily dispersed in water.

The present invention relates to the processing of galactomannans. Polygalacturonase are polysaccharides composed principally of galactose and Manasseh links, and they are usually in the endosperm of the seeds of leguminous plants, such as guar, carob, red trehkulachkovym, fire wood (delonix Royal), etc. Polygalacturonase can be used in its natural form or you can replace one or more functional groups (e.g., carboxymethyl groups). Most often used by polygalacturonase is guar gum. Guar gum is a derivative of the guar gum, namely cationogenic guar gum.

The advantage of using glyoxal as compared with borates is that made by the borates polygalacturonase faster dissociate in water in an acidic environment than processed glyoxal galactomannan. This leads to the formation in the acidic environment of the swollen gel particles or gel mass. If polygalacturonase allow him to remain as separate particles at lower pH values, the leaching of polygalacturonase can be performed in a wider range is e pH and thereby it is possible to remove impurities, not to be deleted at higher pH values. These impurities can reduce the transparency of the aqueous solutions of polygalacturonase or if they will remain with galactomannans, can be detrimental in some applications, such as in personal care products.

In addition, it was found that the treated glyoxal cationogenic polygalacturonase in compositions for personal hygiene effectively act as conditioning agents and thickening agents.

In the context of the present invention cationogenic polygalacturonase or its derivative usually has a degree of substitution (Sz) with the lower limit value, amounting to approximately 0,001, and the upper limit value, amounting to about a 3.0. Preferably, if the lower limit value of Sz for cationogenic products is 0.01, and more preferably of 0.05. Preferably, if the upper limit value of Sz for cationogenic products is 3.0, more preferably of 1.0, and even more preferably of 0.25. Cationogenic polygalacturonase or its derivative proposed in the present invention, typically has a mass-average molecular weight (Mw) with a lower limit value, amounting to about 50000, and the upper limit value, amounting to about 5000000, preferably, if the lower limit of mn is the increase of molecular weight equal to 300000, and more preferably to 400,000. Preferably, if the upper limit of molecular weight equal to 1500000, more preferably 1000000.

Cationogenic functional groups can be introduced in the main chain of polygalacturonase or derived polygalacturonase by known methods. For example, for a sufficient time and at sufficient temperature allows the reaction of polygalacturonase with a tertiary amine or Quaternary ammonium alkylating reagents such as 2-dialkylaminoalkyl, and Quaternary ammonium compounds such as 3-chloro-2-hydroxypropyltrimethylammonium and 2,3-epoxypropyltrimethylammonium. Preferred examples include glycidylmethacrylate salt and 3-halogen-2-hydroxypropyltrimethylammonium salts such as glycidylmethacrylate, glycidylmethacrylate, getidentityprovider, glycidylmethacrylate, glycidylmethacrylate and their corresponding iodides; 3-chloro-2-hydroxypropyltrimethylammonium, 3-chloro-2-hydroxypropyltrimethylammonium, 3-chloro-2-hydroxypropyltrimethylammonium, 3-chloro-2-hydroxypropyltrimethylammonium and their corresponding iodides; and Quaternary ammonium compounds such as the halides compounds containing imidazoline the second ring.

Cationogenic polygalacturonase may also contain other substitutional groups such as non-ionic substituents, i.e. alkyl or hydroxyalkyl, where the alkyl means an aromatic, linear or branched hydrocarbon fragment containing from 1 to 30 carbon atoms (for example, ethyl or hydroxyethyl, propyl or hydroxypropyl, butyl or hydroxybutyl), or anionic substituents, such as carboxymethyl groups that are optional. These optional substituents associated with polygalacturonases by the reaction with these reagents, as (1) alkalinity (for example, ethylene oxide, propylene oxide, butylenes) with the formation of hydroxyethylene groups, hydroxypropyl groups or hydroxybutyl groups or (2) chlormethiazole acid with the formation of carboxymethyl group. The method of obtaining derivatives of polygalacturonase well known in the art. Cationogenic polygalacturonase may also contain a set of one or more other substitutional groups such as nonionic, anionic and cationogenic deputies.

Cationogenic polygalacturonase or their derivatives, applicable in the present invention, it is possible to handle a variety of known reagents such as (1) alkali, (2) acid (3) biochemical oxidants such to the to galactosaminidase, (4) chemical oxidants such as hydrogen peroxide, (5) physical methods using high speed mixing and creating shear forces machines, (6) thermal methods, (7) and enzymes (8) combinations of these reagents and methods. Also optional, you can use such reagents as sodium metabisulfite or inorganic bisulfite.

The preferred destination of the processed glyoxal cationogenic of polygalacturonase proposed in the present invention is the use as a component in compositions for personal care or household compositions hygiene products, where the composition includes processed glyoxal cationogenic polygalacturonase and active ingredient. The active ingredients include, but are not limited to, active ingredients for personal care products, such as, for example, analgesics, anesthetics, antibiotics, fungicides, antiseptics, anti-dandruff, bactericides, vitamins, hormones, anti-diarrhoeal remedies, corticosteroids, anti-inflammatory agents, vasodilator, keratolytic means of a composition for the treatment of dry keratitis means for treatment of wounds, disinfectants and solvents, diluents, excipients and other ingredients such to the to water, ethyl alcohol, isopropyl alcohol, propylene glycol, higher alcohols, glycerin, sorbitol, mineral oil, preservatives, surfactants, propellants, fragrances, essential oils and thickeners.

In the context of the present invention the active ingredient for personal care products should have a positive impact on the user's body. Composition for personal hygiene include compositions for hair care, skin care, sun care and to care for the oral cavity. Examples of ingredients for personal care, which preferably can be included in personal care products proposed in the present invention include, but are not limited to:

1) perfumes, which create olfactory sensation in the form of odor, deodorant perfumes, which in addition to olfactory sensation can also weaken the body odour;

2) means providing a cooling effect on the skin, such as menthol, methylacetate, methylpyrrolidinone, N-ethyl-p-Menten-3-carboxamide and other derivatives of menthol, which lead to a tactile sensation to the skin in the form of a cooling sensation;

3) mitigating tools such as isopropylmyristate, silicone materials, mineral oils and vegetable oils, which lead to tactile oshusheniya the skin in the form of increased softness;

4) deodorants that are not fragrances, which is the reduction or elimination of microflora on the surface of the skin, in particular leading to the formation of body odor. You can also use the predecessors of deodorants that are not fragrances;

5) active ingredients that eliminate the sweating, the action of which is to weaken or eliminate sweat from the skin surface;

6) moisturizers that support skin moisture by moisture or prevent evaporation from the surface of the skin;

7) cleansers that remove dirt and grease from the skin;

8) sunscreen active ingredients that protect the skin and hair from harmful ultraviolet radiation and skin from other harmful radiation. In the context of the present invention is a therapeutically effective amount is usually from 0.01 to 10 wt.%, preferably from 0.1 to 5 wt.% in terms of composition;

9) means for processing the hair, which condition hair, clean hair, detangle hair, act as tools for hair styling tools, adds volume and Shine, tools, color preserving, anti-dandruff, hair growth stimulants, paints and pigments for hair, fragrances for hair, hair straightener, means for bleaching hair, with whom estva to moisturize hair oil for hair and means preventing Curling;

10) the means to care for the oral cavity, such as toothpastes and liquid mouth rinse to cleanse, whiten, deodorize and protect the teeth and gums;

11) denture adhesives, which provide adhesion of dental prostheses;

12) funds for shaving, such as creams, gels and lotions and a lubricating strip blades for safety razors;

13) pigments or dyes, which dye hair, leather or textile materials.

In the context of the present invention the active ingredient for household hygiene products should have a positive impact on the user. Examples of ingredients for household and hygienic means, which preferably can be included in the context of the present invention include, but are not limited to:

1) perfumes, which create olfactory sensation in the form of odor, deodorant perfumes, which in addition to olfactory sensation can also weaken the body odour;

2) a repellent for insects, the effect of which is to remove insects with a specific territory or prevent their contact with skin;

3) means for generating bubbles, such as surfactant, which forms a foam or lather;

4) deso the Oranta or insecticides for Pets, such as pyrethrins, which weaken the smell of Pets;

5) shampoos and active ingredients for Pets, the effect of which is to remove dirt, foreign substances and microorganisms from the surface of the skin and coat;

6) active ingredients technical soap, shower gel and liquid soap, which removes germs, dirt, oil and grease from the surface of the skin, disinfect the skin and condition the skin;

7) universal cleaners that remove dirt, oil, grease, germs from surfaces in places such as kitchens, bathrooms, public areas;

8) disinfectant ingredients that destroy microorganisms or prevent the growth of microorganisms in homes or public areas;

9) active ingredients for cleaning carpets and upholstery, which separate and remove dirt and debris from surfaces, as well as give a soft and pleasant smell;

10) active ingredients for washing, which reduce static electricity and make the fabric softer to the touch;

11) cleaning ingredients that remove dirt, oil, grease, stains and destroy microorganisms;

12) softening ingredients for washing or detergent or fabric, which reduce discoloration when washing, rinsing and what the eye tissue;

13) means for washing, which removes dirt, food residues and microorganisms;

14) cleaning of toilets, which remove dirt and kill germs and deodorize;

15) active ingredients to remove stains in the wash, which help remove stains from clothes;

16) a means for impregnation of fabrics, which improves the appearance of the fabric;

17) the active ingredients for cleaning cars, which remove dirt, grease, etc. from vehicles and equipment;

18) lubricant that reduces friction between the parts.

The above list of active ingredients for personal care and household hygiene products includes only examples and not a complete list of active ingredients that can be used. Other ingredients that can be used in products of this type are well known in the industry. In addition to the above commonly used ingredients composition proposed in the present invention, also not necessarily can include, but is not limited to, ingredients such as a colorant, preservative, antioxidant, dietary Supplement, alpha - or beta-hydroxycitrate, power activity, emulsifiers containing functional groups of the polymers increase the viscosity of the reagents (such as Sol is, i.e. NaCl, NH4Cl and KCl, water-soluble polymers, i.e. hydroxyethylcellulose, hypromellose, and fatty alcohols, i.e. cetyl alcohol), the alcohol containing 1-6 carbon atoms, fats or fatty compounds, antibacterial compound, pyrithione zinc, silicon substance, hydrocarbon polymer, softeners, oils, surfactants, pharmaceuticals, flavors, fragrances, suspendresume agents and mixtures thereof.

In the context of the present invention examples containing functional groups of polymers that can be used in mixtures with processed glyoxal polygalacturonase or its derivatives proposed in the present invention include water-soluble polymers, such as homopolymers of acrylic acid, such as product Carbopol® and anionic and amphoteric copolymers of acrylic acid, homopolymers of vinylpyrrolidone and cationogenic vinylpyrrolidone copolymers; nonionic, cationogenic, anionic and amphoteric polymers of cellulose such as hydroxyethylcellulose, hydroxypropylcellulose, carboxymethyl cellulose, hypromellose, cationogenic hydroxyethylcellulose, cationogenic karboksimetiltselljuloza and cationogenic hydroxypropylcellulose; homopolymers of acrylamide and cationogenic, impoters the e and hydrophobic copolymers acrylamide, the polymers and copolymers of ethylene glycol, hydrophobic polyethers, hydrophobic simple polyetherurethane, hydrophobic modified simple polyetherurethane and other polymers, which are called associative polymers, hydrophobic polymers cellulose, copolymers of ethylene oxide with propylene oxide and nonionic, anionic, hydrophobic, amphoteric and cationogenic polysaccharides, such as xanthan gum, chitosan, carboxymethyl, alginates and gum Arabic.

In the context of the present invention, silicone materials which can be used are polyorganosiloxanes that may be polymers, oligomers, oils, waxes, resins or gums or organopolysiloxane copolymer simple polyether polyols, amodimethicone, cationogenic polydimethylsiloxane and any other silicone materials used in the compositions of personal hygiene or household hygiene products.

In one embodiment, the composition means for hair care or personal care products for the skin, proposed in the present invention, is an aqueous system containing water and the polymer is proposed in the present invention. In one embodiment, the composition means for hair care or personal care products for the skin, proposed in this is sobienie, contains one or more surfactants, including amphoteric surfactants, cationogenic surfactants, anionic surfactants, nonionic surfactants, zwitterionic surfactants, and combinations thereof.

According to the invention it was found that the treated glyoxal cationogenic polygalacturonase with high efficiency can be deposited on the hair/skin and can have a conditioning effect on the keratin substrate.

Such polymers provide other useful effects of styling products, lotions for body care and sun care due to the formation on keratin substrates hydrophobic film, which acts as a barrier between these surfaces and the atmosphere.

The polymers proposed in the present invention, can be used as a conditioning means in shampoos two-in-one, lotions, body care, sun care products, means of preventing the Curling of hair tools and hair styling. The polymers proposed in the present invention can also be used to increase the amount of hair, improve manageability of the hair, restore or maintain hair color, is vladenie skin and moisture retention, holding perfumes, increasing the service life of sunscreen products on the hair, skin and tissues, intensify the aroma and bactericidal action in the care of the mouth and improve the resistance of fabrics to abrasion and light household hygiene products.

Research raschesyvaemost dry and wet hair are a common research methods used to determine the air-handling ability of shampoos and conditioners. To study the conditioning of the ability of funds for skin care use of research methodology softness of the skin or reduce its roughness or feeling the softness of the skin, reducing the transmission of water vapor and improve skin elasticity. For based on surface-active substance, household cleansing products, for which the necessary air-conditioning capacity, such as a means for washing dishes, softeners for fabrics and antistatics, conditioning means providing soft tissue and the elimination of the effects of static electric charge, eliminating the breakage and deformation of tissue, known as peeling. Is also important and can be evaluated for the ability to attach fabric color fastness.

The following examples demonstrate how the stitching cationogenic the guar gum glyoxal and its application in the composition is x for personal hygiene. These examples are intended for illustrative purposes only; all content expressed in parts and percentages are mass, unless otherwise noted. It should be understood that the experts in the related fields of technology without deviating from the essence and scope of the present invention can perform other modifications of the present invention.

COMPARATIVE EXAMPLE 1 and EXAMPLES 2-4

Getting cationogenic the guar gum

Cationogenic guar gum was obtained by known methods without using a crosslinking reagent.

Crushed guar gum (882 g) and water (450 g) was mixed in a reactor with a stirrer in a nitrogen atmosphere. The reactor was purged with nitrogen to remove oxygen. The reaction was carried out at a temperature of 30-50°C after addition of 3-chloro-2-hydroxypropyltrimethylammonium (289 g of a 65% aqueous solution) and subsequent addition of 280 g of 25% sodium hydroxide. The reaction mixture was cooled to room temperature.

When cationogenic crushed guar gum was washed with water to remove salts and impurities, crushed substance was turned into a swollen gel filtration was impossible. A sample of the crushed substance was dried and grinded to determine the salt content by measuring the amount of sulfated ash. The reaction product described in comparative example 1 in Alice 1.

Joining glyoxal

Cationogenic guar gum was prepared analogously to example 1. At the end of the reaction with 3-chloro-2-hydroxypropyltrimethylammonium under stirring was added different amounts of acetic acid and glyoxal. Used amounts of acetic acid and glyoxal are shown in table 1 for examples 2-4. The mixture was heated to a temperature above 45°C for knitting.

Method wash

After cooling the reaction mixture to ambient temperature the crude product was washed with water for 2 hours and Then the product was filtered, dried and grinded.

The residual salt after purification by water is presented in table 1.

Table 1
Joining cationogenic the guar gum
Example1 (comparative example)234
Acetic acid, g022513590
40% Solution of glyoxal, g028 5616
Water rinse2 hours2 hours2 hours40 min
FilteringNo free waterWell-filteredWell-filteredWell-filtered
Cationogenic NW~0,140,140,140,11
Ash content, %11223
Dispersibility 1% of product in water-Well-dispersedWell-dispersedWell-dispersed

The final product was analyzed and found that the degree cationogenic substitution was 0.14 for the products of both examples 2 and 3 and 0.11 for example 4. It was assumed that the product of comparative example 1 had the same Sz as for the introduction of cationogenic groups used the same content to see the sea.

In addition to providing clean water to stitch glyoxal also leads to despergiruemaya in water product. Unstitched product adding to the water quickly forms clumps. Figure 1 and 2 shows that the products obtained in examples 2 and 3, it is easy to dispersibility in water prior to their dissolution.

EXAMPLES 5 and 6 and COMPARATIVE EXAMPLE 7

Additionally sewn products offered in the present invention are presented in examples 5 and 6 in table 2. The product of example 5 was obtained by the method described in example 3 to obtain cationogenic the guar gum with cationogenic NW, equal to 0.14. The product of example 6 was obtained by the method described in example 3, using 30% more 2-hydroxypropyl-3-trimethylammoniumchloride to ensure cationogenic NW, equal to 0.2. The viscosity of 1% solution of the products in the present invention obtained in examples 5 and 6, close to the viscosity of 1% solution of borate crosslinked cationogenic the guar gum obtained for comparison in example 7.

EXAMPLE 8 and 9 and COMPARATIVE EXAMPLES 10-11

Study the conditioning capacity of the products proposed in the present invention

Application cationogenic of polygalacturonase proposed in the present invention in examples 5 and 6, in conditioning shampoos demonstrated in examples 8 and 9, t the blitz 2, compared to the comparative control shampoo containing crosslinked borate cationogenic guar gum of example 7 (example 10), and with a shampoo that does not contain cationogenic guar gum (example 11).

COOKING SHAMPOO

The composition of the conditioning shampoo, are shown in table 2, was obtained by combining 77 wt. parts (h/bn) composition of the premix surfactants, is given in table 3, with 19 PM/billion deionized water and 0.3 h/bn polymer proposed in the present invention, using the upper mechanical Caframo mixer with a toothed blade when rotating with a speed of 600 rpm and the composition was stirred for 45 min at ambient temperature. At this time, to the composition was added 3 h/bn silicone emulsion (Dow Corning 1784) and stirring continued for a further 15 minutes the shampoo Composition kept at ambient temperature during the night and the viscosity of each of the shampoo was determined by using a Brookfield viscometer LVT adapter to study a small sample size, spindle 31, at a given speed of rotation.

The measurement of the viscosity of the shampoo

Comparison of viscosities of the shampoos of examples 8 and 9, which contained stitched glyoxal cationogenic guar gum, proposed in the present invention, the viscosity of the product comparison is sustained fashion of example 11, which does not contain polymer, demonstrated the ability of the products offered in the present invention, to impart viscosity. Viscosity shampoos of examples 8 and 9 were close to the viscosity obtained in example 10 shampoo containing crosslinked borate cationogenic guar gum.

Cationogenic polysaccharides and other polymers are widely used in personal care products, household hygiene tools, industrial and institutional products to provide a function in the finished product using the polymer as geleobrazovanie, binders, thickeners, stabilizers, emulsifiers, distributing and riveting tools and media to improve the rheological characteristics, efficiency, deposition, aesthetic characteristics and release of chemically and physiologically active ingredients in personal care products, household hygiene tools, institutional and industrial compositions. Depending on the destination substrate, which cause the product may be the skin, hair and textile material.

Cationogenic polysaccharides used in tools for hair care for hair. Means for skin care these polymers can provide conditioning of the skin. When detergent and composition for softening Cana these polymers can provide air conditioning, softening, to prevent abrasion and to give the fabric antistatic capability.

Research raschesyvaemost dry and wet hair are a common research methods used to determine the air-handling ability of shampoos and conditioners. The combability when using each of the shampoo composition was determined within 24 h after preparation of a shampoo with the use of two with medium brown natural experimental European hair strands (National Hair Importers, New Jersey), which was pre-treated with a solution of sodium lauryl (LSN), washed and dried overnight at 23°C and 50%relative humidity.

Research raschesyvaemost

Research raschesyvaemost carried out by applying a composition of the shampoo on the locks, uverennye water, at a ratio of 0.5 hours/billion shampoo/1 CH/bln strands of hair. Strands were mixed in 60 seconds, then washed with water at 40°C for 30 C. This procedure was repeated, and then the strands were washed with deionized water and excess water was pressed out of the strands. The strands were placed in a double rassasivayushee apparatus and effort combing when wet was measured 8 times with the help of the device Instron 5542 at a speed of transverse movement of the head, equal to 12.5 cm/min, using the technique of double combing p is ketam hard rubber frequent combs ACE at 23°C and 50%relative humidity. Then the leaves were allowed to dry overnight at 23°C and 50% relative humidity and by the same method double combing investigated raschesyvaemost in the dry state. Normalized energy tangle free, listed in table 2 characterize the full energy combing in terms of the mass of strands.

Features air conditioning products offered in the present invention demonstrate significantly reduced energy combing for examples 8 and 9 in comparison with the corresponding more significant energies combing for containing no polymer control shampoo in example 11. Energy combing for examples 8 and 9 are in good agreement with the energy combing for shampoo containing crosslinked borate cationogenic guar gum in example 10.

Table 2
Stitched glyoxal cationogenic galactomannan
Features air conditioning shampoo
Example567 (Comparative example)1
Processing glyoxalglyoxalBorat
Cationogenic NW0,140,2560,13
Humidity, %7,87,3
The viscosity of 1% aqueous solution
raw, SP
265026003500
Example8910 (comparative example)11 (comparative example No. polymer)
The viscosity of the conditioning shampoo (Brookfield LVT, spindle #31, the adapter for small sample, 6 rpm, pH 5,1), SP485557806010 (3 rpm; pH 5.8)1421 (12 turns/m is n)
Normalized energy combing wet (grams-force mm/d)126213459632340
Normalized energy brushing in a dry state (grams-force mm/d)301281242670
1N-Hance® 3196 cationogenic guar gum, crosslinked borate (Aqualon Division of Hercules Incorporated)

Table 3
The composition of the premix shampoo
IngredientManufacturerThe Mac. parts
Deionized water896
Stepanol AMStepan1027
Steol CA-330310
Amphosol CA 186
Tool, giving lubricityLonza16,25
25 wt.% Ammoniacal (aqueous solution)65

EXAMPLES 12-13 and COMPARATIVE EXAMPLE 14

The use of funds for skin care, tools for body wash

Thickening ability of the products offered in the present invention, in the compositions of detergents for washing body are shown in table 4. Composition means for washing the body was prepared by addition of 0.3 h/bn polymers proposed in the present invention in examples 5 and 6 to 76 hours/bn composition of premix preparations for washing the body, indicated in table 5, and water was added to bring the volume to 100). Mixing was performed using a top mechanical mixer with a toothed blade for 1 h pH cleansers for the body was equal to 5.6.

Means for washing the body of examples 12 and 13 contain the polymers proposed in the present invention in examples 5 and 6, respectively. Addition polymers proposed in the present invention, the composition cleansers for the body leads to an increase in the viscosity of the preparations for washing the body in comparison with a comparative control means m is Thiey body, not containing cationogenic the guar gum powder obtained in example 14.

Table 4
The characteristics of the products proposed in the present invention, the compositions of funds for body wash
121314
PolymerExample 5Example 6No
Viscosity/SP1512050201864
1Brookfield LVT, spindle 3, 12 rpm

Table 5
The composition of the premix means for body wash
IngredientManufacturerThe Mac. parts
Stepanol AMStepan Chemical Co.697
Steol CA 330 2500
Amphosol CA500
Deionized water279
Tool, giving lubricityLonza Chemicals24,5

In the context of the present invention cationogenic polygalacturonase or its derivative usually has cationogenic the degree of substitution (Sz) with the lower limit value, approximately equal to 0.001, and the upper limit equal to about a 3.0.

In addition to using glyoxal as a crosslinking reagent for polygalacturonases and their derivatives, other reagents that form a swelling in water or despergiruemaya in the water complex with polygalacturonase, also can improve the dispersibility of polygalacturonase in the water. These reagents include oligomers or polymers containing phosphate, sulphate, sulphonate, carboxylate or carbonate groups, including sodium hexametaphosphate, polystyrenesulfonate and proteins, such as casein, or whey, which can form despergiruemaya in the water complex with cationogenic polygalacturonase. These reagents also include anionic, cationogenic and amphoteric surfactants as the active substance, such as lauryl ammonium, sodium lauryl sulfate, cetyltrimethylammonium or

- bromide and cocamidopropylbetaine.

In addition, the crosslinking of polygalacturonase and giving him the ability to dispergirujutsja in water it is possible to use other cross-linking reagents, such as chloroformic cross-linking reagents on the basis of the siloxane, such as triethoxysilane.

Dispergirujutsja in water cross-linked products described above can be used in other areas, such as oil, personal care products, textile industry, paper industry, plating industry, food industry, where they can dispersing and dissolving in the aqueous phase by appropriate selection of pH or addition of salts.

Although the present invention is described with reference to the preferred embodiments of, it should be understood that without deviating from the essence and scope of the claimed invention in its shape and features, you can make various changes and modifications. Such changes and modifications are included in the scope of the attached claims.

1. Composition hygiene products, including custom made glyoxal cationogenic polygalacturonase and active ingredient.

2. The composition according to claim 1, in which the crosslinked glyoxal polygalacturonase includes stitched glyoxal is m cationogenic polygalacturonase.

3. The composition according to claim 1, in which the crosslinked glyoxal cationogenic polygalacturonase includes sewn glyoxal cationogenic guar gum.

4. The composition according to claim 3, in which are sewn glyoxal cationogenic guar gum has a degree of substitution (Sz) with the lower limit value, amounting to approximately 0,001, and the upper limit value, amounting to approximately 3,0.

5. The composition according to claim 3, in which are sewn glyoxal cationogenic guar gum has a mass-average molecular weight (Mw) with a lower limit value, amounting to about 50000, and the upper limit value, amounting to about 5000000.

6. The composition according to claim 1, which is a composition for personal hygiene, selected from the group comprising a cleansing composition, conditioners and products for hair styling.

7. The composition according to claim 6, which is a composition for personal hygiene, additionally comprising one or more surfactants selected from the group comprising amphoteric surfactants, cationogenic surfactants, anionic surfactants, nonionic surfactants, zwitterionic surfactants, and combinations thereof.

8. The composition according to claim 7, additionally comprising one Il the greater the number of additional ingredients, selected from the group including preservatives, thickeners containing functional group polymers, viscosity modifiers, electrolytes, agents regulating pH, perfumes, dyes, protection from ultraviolet radiation, silicon substances, anti-dandruff, vitamins, derivatives of vitamins.

9. The composition according to claim 6, which is a composition for personal hygiene, which is a composition for hair care.

10. The composition according to claim 6, which is a composition for personal hygiene, which is a composition for skin care.

11. The composition according to claim 1, which is a composition of household hygiene.

12. Despergiruemaya cationogenic polygalacturonase, including custom made glyoxal polygalacturonase in which stitched glyoxal polygalacturonase has a degree of substitution (Sz) with the lower limit value, amounting to approximately 0,001, and the upper limit value, amounting to approximately 3,0.

13. Despergiruemaya cationogenic polygalacturonase indicated in paragraph 12, in which the degree of substitution (Sz) lower limit value is about 0,01.

14. Despergiruemaya cationogenic polygalacturonase indicated in paragraph 12, in which the degree of substitution (Sz) lower limit value is approximately 0.05.

15 Despergiruemaya cationogenic polygalacturonase indicated in paragraph 12, where the degree of substitution (Sz), the upper limit is about 1.0.

16. Despergiruemaya cationogenic polygalacturonase indicated in paragraph 12, in which the degree of substitution (Sz), the upper limit is approximately 0.25 in.

17. Despergiruemaya cationogenic polygalacturonase indicated in paragraph 12, in which stitched glyoxal polygalacturonase has a mass-average molecular weight (Mw) with a lower limit value, amounting to about 50000, and the upper limit value, amounting to about 5000000.

18. Despergiruemaya cationogenic polygalacturonase on 17, in which the lower limit value of the mass-average molecular weight (Mw) is approximately 300000.

19. Despergiruemaya cationogenic polygalacturonase on 17, in which the lower limit value of the mass-average molecular weight (Mw) is equal to about 400,000.

20. Despergiruemaya cationogenic polygalacturonase indicated in paragraph 12, in which stitched glyoxal polygalacturonase includes sewn glyoxal cationogenic guar gum.



 

Same patents:

FIELD: personal use articles.

SUBSTANCE: invention relates to methods of hygiene in toilet, for washing dishes in the sink and dishwasher.

EFFECT: offer of a cleaning unit which can be easily located on a solid surface, and which is washed away with many washings, and leaves no residue that can not be easily removed, such as with toilet brush.

FIELD: chemistry.

SUBSTANCE: invention relates to a method of cleaning at least part of a surface and/or fabric, involving: optional steps for washing and/or rinsing the surface and/or fabric; bringing the surface and/or fabric into contact with a washing solution containing a perhydrolase enzyme and a substrate for said enzyme, where the initial pH of the washing solution is alkaline and the amount of the perhydrolase enzyme and substrate is sufficient to lower the pH of the washing solution to 6.5 or lower; and optional washing and/or rinsing the surface and/or fabric, where said contact takes place during the washing cycle, and where lowering of the pH of the washing solution improves efficiency of the component of the washing solution.

EFFECT: improved method for bleaching textile.

7 cl, 5 ex, 5 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to oil-containing starch granules for delivering perfume oil as beneficial effect endowing additives to a substrate, containing: (a) starch in amount which forms an effective matrix for said granules; (b) perfume oil containing ingredients with Clog P equal to at least 3; and (c) an effective amount of an amidoamine compound for inhibiting migration of said oil to the surface of the said starch granules, said compound has the following structure: (I) or (II), where radicals are described in the claim separately for each structure. The invention also relates to a method of producing oil-containing starch granules, comprising the following steps: (a) preparing a dispersion of starch in water to form a starch suspension; (b) melting an effective amount of the amidoamine compound of structure (I) or (II) to obtain a molten amidoamine compound; (c) adding perfume oil to the molten amidoamine compound from step (b) to obtain a solution of the amidoamine compound in perfume oil; (d) adding the solution from step (c) to the starch suspension from step (a); (e) homogenisation of the obtained suspension by mixing to obtain a homogeneous mixture; and (f) spray drying the said homogeneous mixture to obtain oil-containing starch granules. The invention also relates to a method of washing fabric, comprising the following steps: (a) preparation of an aqueous solution containing an effective amount of the oil-containing starch granules in claim 1 or 2, and (b) bringing the fabric to be washed into contact with the aqueous solution from step (a). The invention also pertains to a laundry detergent composition containing: (a) at least one surfactant; and (b) an effective amount of oil-containing starch granules.

EFFECT: prolonged existence of the aromatising agent in the substrate owing to inhibition of migration of perfume oil to the surface during laundry.

7 cl, 5 tbl

FIELD: textile industry.

SUBSTANCE: lightproof composition added in process of cloth rinsing has viscosity of less than 500 mPas after at least one cycle of freezing-unfreezing and contains from approximately 5 to approximately 30 wt % of active component, more than 5 wt % of polyol, which represents polyatomic alcohol that is not ethylene glycol, propylene glycol, diethylene glycol or dipropylene glycol and 0.1-10 wt % of additional softener selected from hydrophobised ether of saccharose, cationic starch, aminofunctional silicon or their mixtures. Active component represents compound or mixture of compounds, having the following formula: {R4-m-N+-[(CH2)n-Y-R']m}X-, (a), where each R is hydrogen, short chain C1-C6, poly(C2-3 alkoxy), benzyl, or their mixtures; m = 2 or 3; n = 1-4; Y = -O-(O)C- or -C(O)O; sum of carbon atoms in each R1=C11-C21, for each R1, which represents hydrocarbyl or substituted hydrocarbyl group; and X-anion compatible with softener; or {R4-m-N+-[(CH2)n-Y-R']m}X-, (b), where each R is hydrogen, short chain C1-C6, poly (C2-3alkoxy), benzyl, or their mixtures; m = 2 or 3; n =1-4; Y=CH2, -NR-C(O)-, or -C(O)-NR- and each Y is same or different; sum of carbon atoms in each R1 minus (n+1), when Y is CH2, is equal to C12-C22, for each R1, which represents hydrocarbyl or substituted hydrocarbyl group; and X- any anion compatible with softener; or (c), where each R, R1, and A- have values given above; each R2 -C1-C6 alkylene group; and G - atom of oxygen or -NR-.

EFFECT: softener has good dispersive ability and spreading property when stored at low or high temperature.

9 cl, 1 tbl, 4 ex

FIELD: biochemistry; production of the water purifying diphasic compositions.

SUBSTANCE: the invention is pertaining to the water purifying diphasic compositions. The composition contains (in mass %): (a) 5-75 of the surface-active substance; (b) at least 2.5 molecules of polydextrose; (b) at least, 2.5 - 50 molecules of sucrose; and (d) - the water and auxiliary components - up to the balance. The other version is the composition containing (in mass %): (a) 5-75 of the surface-active substances; (b) at least - 2,5 molecules of molecules of polydextrose; (c) at least from 0.5 up to approximately 4 the salt; (d) at least - 2.5 - sucrose; and (e) the water and the auxiliary components to the balance. These compositions contain, at least, two visible separated layers on the basis of the water at aging the compositions without shaking or steering. The technical result of the invention is the increased stability.

EFFECT: the invention ensures the increased stability of the water purifying diphasic compositions.

12 cl, 3 tbl, 14 ex

FIELD: agriculture; chemical industry; other industries; production of the water two-phase purifying compositions.

SUBSTANCE: the invention is pertaining to the water purifying two-phase compositions. The composition contains: (a) about 5-75 % of the mass of the surface-active substance, (b) at least about 15 % of the molecule or the molecules of the polydextrose, where the polymerization degree makes from the nearby 4 to the nearby 22,(that corresponds to the molar weight from nearby 600 to nearby 3600) and (c) the water and the auxiliary components to the balance. The composition contains at least two visible separated layers on the basis of water at keeping without stirring or hashing. The composition containing from 0.5 up to nearby 3 % of the salt, contains at least about 10 % of the polydextrosew for induction of the two-phase formation. The technical result of the invention is the increase of stability.

EFFECT: the invention ensures the increase of stability of the water purifying two-phase compositions induced by the polysextrose.

10 cl, 4 tbl, 15 ex

FIELD: aqueous composition for fabric softening.

SUBSTANCE: claimed composition contains (mass %): (i) at least one cationic compound - fabric softening agent, having two or more alkenyl chains wherein each chain contains 8 or more carbon atoms; and (ii) at least one sugar oil derivative. Cationic compound (i) and/or sugar oil derivative (ii) are individually mixed with other active component of fabric softening composition, excluded anionic surfactants, water, paints, conserving agents or other optional components with small concentration, to provide intermediate mixture, followed by mixing of cationic compound (i) and sugar oil derivative (ii). Aqueous fabric softening composition produced by claimed method and method for fabric treatment using the same, also are disclosed.

EFFECT: homogeneous composition with improved cleavage resistance.

12 cl, 9 tbl, 16 ex

The invention relates to foaming detergent compositions that can be applied in individual detergents produced in the form of viscous liquids, creams or gels

The invention relates to a molded product, the detergent or cleaning action, primarily tablets, and method of production thereof

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology and represents a moisturising skin product for external application containing one or more compounds specified in a group consisting of lysyl-β-alanine presented by general formula (1), and its salts.

EFFECT: invention provides the excellent long moisturising effect.

3 cl, 15 ex, 2 tbl

Make-up foundation // 2458677

FIELD: medicine.

SUBSTANCE: invention refers to cosmetic industry and represents a make-up foundation containing a lipid phase, structure-forming emulsifiers, pigments, preservatives, a perfume composition differing by the fact that as biologically active substances it contains herbal propylene glycol extracts of wild camomile (Matricaria chamomilla), St. John's wort (Hypericum perforatum), nosebleed (Achillea millefoium) in the ratio 2:1:1, low-molecular hyaluronic acid, antioxidant dihydroquercetin; the cream base contains propylene glycol dispersions of pigments COVASOP (white titanium dioxide CI 77891, red ferric oxide CI 77491, black ferric oxide CI 77499), light diffusing pigment Matlake OP A, organosilicon elastomer DC 9701, UV filters Escalol 557 and Escalol 567, Cyclomethicone DC 345, organosilicon emulsifier DC 5329, acrylate emulsion of copolymer Salcare SC80, triethanolamine, preservative SHAROMIX MO, perfume Curt Georgi and thermal water of Suvorovsky No.1 thermal spring with the cream ingredients taken in certain proportions, wt %.

EFFECT: invention provides effective skin smoothing, nourishing, and also UV protection, improved skin tonicity and elasticity.

3 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: invention refers to cosmetics, more specifically concerns a day-time cream-gel for mature skin, containing a cream base DTM+ with eftiderm, jojoba oil, eleuterococcus, wheat germs oil, almond oil, cedar oil; aloe vera, collagen, aralia, common horse chestnut, camomile, extrapone V, propolis, vitamin B2 and a perfume.

EFFECT: invention provides the agent normalising skin condition possessing the improved organoleptic properties, high antibacterial, anti-inflammatory, tonic, moisturising and reparative action, and also inhibiting the process of senescence.

1 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions relates to dentistry, namely to mineral and vitamin complex for strengthening tooth enamel, as well as compositions for oral cavity hygiene, including claimed complex, in particular to toothpastes. Vitamin and mineral complex for tooth enamel strengthening contains the following components: per 100 wt fractions of hydroxyapatite - 15.0-30.0 wt fractions of aminofluoride, 3.0-24.0 wt fractions of extract of plant Crithmum Maritimum and 0.1-0.2 wt fractions of pearl powder. Complex can additionally contain, at least, one extract of alga, selected from the group including Himanthalia Elongata, Laminaria Digitata, Laminaria Saccharina, Lithothamnium Calcareum, Palmaria Palmata, Porphyra Umbilicalis and Spirulina Maxima Extract in amount from 3.0 to 12.0 wt fractions. Also claimed are compositions for oral cavity hygiene with application of said complex, in particular, toothpaste.

EFFECT: application of compositions for oral cavity hygiene based on claimed vitamin and mineral complex ensures high cleaning capability, anti-caries effect, reduction of gum inflammation, reduction of teeth sensitivity to temperature and tactile stimuli and reduction of pigmented plaque.

10 cl, 10 tbl, 1 ex, 1 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of cosmetics, in particular deals with cream-gel for eye-surrounding skin care, which contains base for creams DTM+ with eftidermon, jojoba oil, Siberial ginseng, fragrance, apricot oil, wheat germs, Shi; collagen, horse chestnut, elastin, vitamins A and E.

EFFECT: invention provides preparation, which normalises skin state, has improved organoleptic properties, higher antibacterial, anti-inflammatory, tonic, moisturising and reparative effect, as well as prevents skin ageing and wrinkle formation.

1 tbl

FIELD: medicine.

SUBSTANCE: invention relates to field of cosmetology and represents makeup-facilitating overlay, possessing layered structure, and on one surface of main layer there is a layer of self-adhering material, in which (1) main layer represents a layer of polyurethane elastomer, which has temperature of vitrification equal 0°C or lower, (2) layer of self-adhering material represents layer of acrylic self-adhering material, consisting of copolymer, which contains, at least, one monomer link, selected from group, consisting of alkylacrylate and alkylmetacrylate, and each of them contains alkyl group, containing from 8 to 12 carbon atoms in proportion 70 wt % or more, and (3) thickness of main layer constitutes from 1 to 15 mcm and total thickness of these both layers constitutes 2 to 20 mcm.

EFFECT: invention ensures inconspicuousness of overlay in glued state, absence of perception of physical discomfort, does not cause rash and ensures obtaining natural makeup.

12 cl, 5 ex, 4 tbl, 3 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical field and deals with preparation against alopecia for external application, which contains 1-[2-((2S)-2-{5-[(3,4-dimethoxyphenoxy)methyl]-1,2,4-oxadiasol-3-yl}pyrrolidin-1-yl)-1,1-difluor-2-oxoethyl] -3,3,5,5-tetramethylcyclohexanol as active ingredient. In addition, invention relates to method of fighting alopecia by means of said preparation, as well as application of said compound for production of preparation against alopecia.

EFFECT: invention ensures preparation which stimulates hair growth and is useful for prevention and treatment of alopecia.

5 cl, 1 dwg, 6 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions relates to composition for oral cavity care which reduces and/or eliminates perception of teeth sensitivity, and its application for improvement and/or support of oral cavity health. Composition for oral cavity care contains: (a) adhesive material; and (b) particles of precipitated silicon dioxide, which have average size from 1 to 5 mcm, where said particles of silicon dioxide constitute at least 5% weight of composition. Claimed is application of such composition for reduction of teeth sensitivity, in particular, for occlusion of open dentinal tubule within mammal tooth surface. In addition, claimed is application of composition which contains adhesive material, said particles of silicon dioxide in amount of at least 5 wt % of composition and therapeutic means, in particular, antibacterial means, for support or improvement of general state of mammal health.

EFFECT: application of composition ensures efficient reduction of teeth sensitivity.

24 cl, 1 tbl, 1 ex, 1 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to medicine, namely to field of sanitary and hygiene, and deals with means for oral cavity care. Claimed therapeutic and proh[phylactic paste contains dicalcium phosphate dihydrate, aerosil, sodium carboxymethylcellulose, sodium salt of methylparaben, sodium salt of propylparaben, sorbitol, sodium lauryl sulfate, perfluorodecalin, allantoin, sodium monofluorophosphate, sodium pyrophosphate, potassium pyrophosphate, metronidazole, calcium glycerophosphate, sodium saccharinate, fragrance and water in specified component ratio.

EFFECT: composition of claimed therapeutic and prophylactic toothpaste makes it possible to extend assortment of therapeutic and prophylactic toothpastes due to creation of toothpaste, ensuring activation of blood microcirculation processes in periodontal tissues and performing essential positive impact on trophics of periodontal tissues, prevention of tartar formation and recovery of natural whiteness of teeth, which in its turn, increases efficiency of oral cavity sanation and reduces possibility of development of periodontal disease phenomena.

3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of cosmetics and represents composition for treatment of dermatologic disorders characterised by the fact that it has form of cream-gel and contains in physiologically acceptable medium: from 0.0001 to 20% of dispersed benzoyl peroxide, from 0.0001 to 20% of at least one retinoid, at least one lipophilic compound, which contains fatty phase, and from 0.001 to 15% of at least one pH-independent gelling agent.

EFFECT: invention ensures homogeneity, physical and chemical stability of active composition ingredients.

18 cl, 4 ex

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology and represents a moisturising skin product for external application containing one or more compounds specified in a group consisting of lysyl-β-alanine presented by general formula (1), and its salts.

EFFECT: invention provides the excellent long moisturising effect.

3 cl, 15 ex, 2 tbl

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