Biologically active food additive for prevention of men's erectile dysfunction

FIELD: food industry.

SUBSTANCE: invention relates to food industry, in particular, to biologically active food additives. The biologically active food additive for prevention of men's erectile dysfunction contains L-Arginine and drone brood at the following ingredients ratio, wt %: L-Arginine - 50.0 - 96.2, drone brood - 3.8 - 50.0%.

EFFECT: invention allows to ensure combined synergistic effect in relation to erection acceleration due to joined usage of the components of the biologically active food additive in proposed quantity.

2 cl, 1 ex

 

The invention relates to food industry, namely, biologically active additives (BAA) to food for the prevention of erectile dysfunction in men, based on natural components.

Known food SUPPLEMENTS containing drone brood in the amount of 1-70 wt.% - EN 2390270 C1, 27.05.2010. A disadvantage of the known tool is the long time development of therapeutic effect (up to 2 weeks).

Known remedy to prevent erectile dysfunction in men, containing L-arginine in the amount of 50 to 80 mass parts (KR 20030049063 AND 25.06.2003). A disadvantage of the known means is: all the pharmacological effects of L-Arginine associated with its conversion in the body of a man in the molecule nitric oxide (NO). Nitric oxide, in turn, participates in the regulation of circulatory, immune and neurotransmitter function, liver function, blood clotting, sexual function. To achieve therapeutic effect requires a very large amount of L-Arginine from 2.8 g to 4 g (Russian encyclopedia of dietary supplements, Moscow, "GEOTAR-Media", 2007). This number is not valid for release SUPPLEMENTS in the form of tablets or capsules, as a large tablet or capsule, it is impossible to make and even more to swallow. Another significant disadvantage of the known tool is the I fact, that L-Arginine is not an essential amino acid and can also be done with ordinary food. Therefore, there is a risk that formed in large amounts of NO can be reborn in a very toxic long-lived peroxynitrate-anion. Unlike NO, peroxynitrite-anion stimulates the seizure of calcium by mitochondria, rasamma thus the processes of tissue respiration and oxidative postlarvae, which eventually leads to the downfall of the energy potential of nerve cells with ensuing consequences.

Research of prior art on this issue have shown that there are a large number of medicines, promoting elimination of erectile dysfunction.

Known drug VIAGRA on the basis of the medicinal substance Sildenafil citrate therapeutic dose of 25 mg Side effects: cardio-vascular system: headache, flushing, vasodilation. CNS: dizziness, increased muscle tone, insomnia. On the part of the digestive tract: indigestion, diarrhea, nausea. From the side of the musculoskeletal system: pain in muscles and joints. From the organs of the respiratory system: nasal congestion, pharyngitis, rhinitis, sinusitis, infections of the respiratory tract, respiratory disorders. From the senses: slight vision changes (color perception, clarity), conjunctive is. From the side of the skin: rash. From the urogenital system: urinary tract infections, disorders of the function of the prostate gland. Other: asthenia, pain (including abdominal pain), flu-like symptoms, rare cases of priapism.

Known drug Cialis-based medicinal substance Tadalafil therapeutic dose of 5 mg Side effects: body as a whole: asthenia, facial swelling, fatigue, pain. From cardiovascular system: angina pectoris, chest pain, hypotension, hypertension, myocardial infarction, orthostatic hypotension, palpitations, syncopal status, tachycardia. On the part of the digestive tract: the change of functional hepatic tests, diarrhea, dry mouth, dysphagia, esophagitis, gastroesophageal reflux, gastritis, increased levels of gamma glutamyltranspeptidase, loose stools, nausea, pain at the top of the abdomen, vomiting. From musculoskeletal: arthralgia, pain in the neck. From the nervous system: dizziness, hypesthesia, insomnia, paresthesia, somnolence, vertigo. From the respiratory system: dyspnea, nasal bleeding, sore throat. From the side of the skin: rash, itching, sweating. Side of eye: visual impairment, change in color vision, conjunctivitis (including conjunctival hyperemia), eye pain, increased slezootdelenia, swelling of the eyelids.

D. the op perate these drugs are based on the physiological mechanism of erection, which involves the release of nitric oxide in the cavernous bodies of the penis during sexual stimulation.

Object of the invention is a drug that is responsive to the status of BAD, which eliminated contraindications, available medicines listed above, while also taking into account the known preventive means creating tools that do not have the disadvantages of the known prototypes:

1) the duration of the development of therapeutic effect,

2) a possible overdose,

3) the impossibility of making this tool in the form of tablets or capsules because of the large weight of the mixture.

SUPPLEMENTS should include the minimum number of pharmacopoeial ingredients with the most pronounced medicinal properties against erectile dysfunction with minimal side effects and contraindications.

The BAD must ensure that the ingestion of the maximum preservation of the amount of biologically active substances, to be convenient for use and storage of consumer form, to have high manufacturability in terms of mass production.

The result achieved with the use of the invention is to obtain a metered dose of the drug that meets the status BAD, consisting of a minimum number of highly effective ingredients, the total effect of which, with the ne side, provides effectiveness against erectile dysfunction, and with another - has an extended range of preventive and curative effects on the body. Technological features of manufacture BAD not create difficulties when mass production and consumer gives the perception of a body of the whole amount of biologically active substances and convenience when receiving and storage.

The invention consists in that the proposed biologically active food Supplement for the prevention of erectile dysfunction in men, containing, according to the invention, L-Arginine, and drone brood in the following ratio of ingredients, wt.%:

L-arginine50-96,2%
Drone brood3,8-50%

The claimed SUPPLEMENTS made in powder, tablet or capsule form, and can also be made in the form of an aqueous-alcoholic extract and forms created on the basis of this extract, namely: powder, tablets and capsules.

To solve this problem it was proposed to strengthen the positive therapeutic effect of L-Arginine additional introduction of the drone brood, as a donator on the new entomological hormones: prolactin, estradiol, progesterone, testosterone - has a stimulating effect on the androgenic functions of men. Rich in vitamins and hormones, non-germanosilicate drone brood is effective for disturbances of a hormonal background. There is a possibility to achieve a harmonious work of all organs and systems of the human body.

When accomplish the task, we have found that a synergistic effect in improving sexual function in men due to the common use of the components of the proposed Supplement.

The actions of the drone brood and L-Arginine differently and their application separately is less effective than joint use. This has the following explanation:

L-arginine causes the blood flow in the pelvic area, increases the strength and duration of the blood supply of genitals of men, which contributes to the appearance of an erection. However, this effect is not always possible to achieve. This is because many men with erectile dysfunction violated the biochemical process of converting L-Arginine to NO. To avoid this, we need the so-called "conductors" - other amino acids and minerals, particularly zinc, magnesium, potassium, choline, oleic, linoleic, linolenic and other fatty acids, and vitamins a, C, E, contained in Trou what newom the brood.

The same action of the drone brood is associated with entomological hormones (prohormones) and primarily with testosterone, the maintenance of which in the body is a necessary condition for stimulating ganglion of the spinal cord that control erection. However, as noted above, the application of one of the drone brood is also not effective because of the slow development of therapeutic effect. The use of the so-called "starter" - nitric oxide. It is not in the drone brood, but it can be produced from L-Arginine.

In the course of our research it was found that a combined use of drone brood and L-Arginine in one product in the stated proportions gives sverhsummarny effect by accelerating the emergence of an erection. In this issue L-arginine is a catalyst or "starter".

An example of a product

L-Arginine 250 mg drone brood 50 mg

Taking into account contraindications active ingredients of the proposed drug, their mutual synergistic effects on each other, and also considering the fact that

the tablet or capsule more than 1200 mg just don't swallow (gag reflex), and therefore it seems appropriate to set the range of the proposed drug is as follows:

L-Arginine is in an amount of from 250 mg to 1160 mg,

drone brood in Koli is este from 40 mg to 950 mg.

Prepared powdery mixture tabletirujut or kapalit.

For the prevention of erectile dysfunction in men BAA composition of L-Arginine 250 mg drone brood 50 mg take 2 tablets 2 times a day for 1 month outside of mealtimes. A break in reception is 1 month.

This technical result is conrmed by a study in the medical center "Secrets of longevity" Penza, which showed high efficiency funds compared to control groups.

The study included 15 men diagnosed with Erectile dysfunction and chronic prostatitis, aged 30 to 50 years (mean age 43 years). The duration of erectile dysfunction ranged from 6 months to 3 years (mean duration 1 year). From all the men who participated in the study, obtained the consent.

The experimental group (10 persons) were assigned to the claimed means 2 tablets 2 times a day in the first half of the day.

1-I control group (10 persons) received L-Arginine 250 mg, 2 tablets 2 times a day in the first half of the day.

2-I control group (10 persons) received drone brood 50 mg 2 tablets 2 times a day in the first half of the day.

Examination of the patients included examination, collection complaints in accordance with the scale of symptoms IPSS, international questionnaire indec is and erectile function (IIEF), objective factors: ultrasound of the prostate gland, the General analysis of blood, urine, including palpation of the prostate. Examination of patients was performed before and after drug administration.

The effectiveness of the funds was estimated by the change indicators ICEF. During the week, before and during the reception, the patients kept a diary assessment of the disease, which recorded the frequency and degree of sexual attraction, evaluation of erection, frequency of sexual acts and feelings. The analysis showed significant improvement in sexual function in the course of receiving funds and improving indicators of sexual function of the patient, as well as achieving the best results in the experimental group compared with both control groups.

In the experimental group action funds begins 2-3 hours after administration of the funds, regardless of age and degree of sexual disorders, providing a full sexual relationship. So, overall satisfaction 90%satisfaction with sexual intercourse 90%, erectile function 100%, the indicator of the feeling of orgasm, changing sensations 80%, the number of ejaculations increased by 80%, the refractory period after ejaculation has decreased by 100%, increased libido (libido) was observed in 100% of patients.

In 100% of patients with symptom and chronic prostatitis had a good effect from the drug, namely, the disappearance of discomfort when urinating, pulling pain in the perineum. According to the questionnaire marked reduction of all symptoms of chronic prostatitis, increase the brightness and duration of sexual sensations, duration of sexual intercourse. We also observed a change in the quality of erections and an increase in the number of sexual acts per unit time, which contributed to improved sexual self-esteem.

The study reported improvement of quality of sexual life and the subjective condition of patients. Any clinically significant changes in the study of blood sex hormones and changes in prostate size have been identified. In this study, side effects were not identified, declared the tool is well tolerated, safe and convenient to use.

In the 1st test action group funds begins 2-3 hours after administration of the funds, regardless of age and degree of sexual disorders, not providing a full sexual relationship. So, overall satisfaction was 20%, satisfaction with sexual intercourse 20%, erectile function 20%, the indicator of the feeling of orgasm, changing sensations of 20%, the number of ejaculations increased by 20%, the refractory period after ejaculation has not changed in 100%, increased libido (libido) noted that the network 100% of patients.

In the 2nd test action group funds begins within 4-6 hours after administration of the funds, regardless of age and degree of sexual disorders, providing a full sexual relationship. So, overall satisfaction was 60%, satisfaction with sexual intercourse 60%, erectile function 70%, the indicator of the feeling of orgasm, changing sensations 60%, the number of ejaculations increased by 40%, the refractory period after ejaculation has changed in 40%, increased libido (libido) was observed in 100% of patients.

In the course of the research the above synergistic effect was observed when using the components in the stated ratio, wt.%: L-Arginine 50-96,2 and drone brood 3,8-50.

On the basis of the conducted research it can be concluded that the claimed BAD is highly effective in patients with erectile dysfunction with chronic prostatitis and superior in many respects its individual components (1 and 2 control groups).

The effect of the claimed SUPPLEMENTS aimed at:

- increased libido, namely getting sverhsummarny effect;

- improving the quality of erections;

- increased the feeling of orgasm, changing perceptions;

- stimulation of brightness and duration of sexual sensations;

- satisfaction of sexual intercourse

- increase sexual self-esteem;

- reduced symptoms of chronic prostatitis.

The claimed BAD because of security, lack of addiction and side effects can be used regularly or on occasion, well tolerated, safe and convenient to use.

1. Biologically active food Supplement for the prevention of erectile dysfunction in men, characterized in that it contains L-Arginine and drone brood in the following ratio of ingredients, wt.%:

L-Arginine50,0-96,2,
drone brood3,8-50,0

2. Biologically active food Supplement according to claim 1, characterized in that it can be made in the form of powder, tablets or capsules.



 

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2 cl, 2 ex

FIELD: food industry.

SUBSTANCE: invention relates to meat industry, in particular, to methods for meat-and-vegetable food concentrates production using soya. The method envisages preparation of meat paste of "Broiler chickens necks" semi-product by way of defrosting and barothermal treatment as per mode: milling into paste-like condition and homogenisation till production of homogeneous consistency paste. Soya protein clot preparation is performed by way of protein coagulation with 5% solution of ascorbic acid in a disperse soya system, the soya protein clot conditioned till its moisture content is equal to 35-40%. The soya protein clot is mixed with the meat paste at a ratio of 1:1; the produced mixture is moulded into 1-2 mm diameter granules; the granules are dried at a temperature of 100-105°C with exposure during 25-30 minutes.

EFFECT: method ensures production of a concentrate with high nutritive and biological value containing an active vitamin-mineral complex using a simplified technology.

2 cl, 2 ex

FIELD: food raw and industry.

SUBSTANCE: invention relates, in particulate, to new nutrient sources of trace elements with using the milk proteins hydrolyzate enriched with trace elements. The nutrient chelate complex comprising the milk proteins hydrolyzate and trace elements bound to chelate compounds comprises trace elements in the range of concentrations 1-30 mg/g being from that at least 90% are in an organic form. Invention provides the preparing the nutrient source of trace elements with high assimilability of its components, improved functional properties and reduced adverse unfavorable effect in overdosing due to the elevated content of trace elements in organic form in its composition.

EFFECT: valuable properties of complex.

3 cl, 6 ex

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