Liquid for forming aerosol for use in aerosol inhaler

FIELD: chemistry.

SUBSTANCE: liquid for forming aerosol which is used as a solution of aromatic substance contains basic components and adipic acid which is added to the basic components. The basic components include a solvent and a lipophilic aromatic substance containing L-menthol dissolved in the solvent. The solvent is propylene glycol.

EFFECT: use of the liquid enables formation of a significant amount of aromatic aerosol, having long life.

4 cl, 2 dwg, 2 tbl, 6 ex

 

The technical field

The present invention relates to a liquid for formation of aerosols suitable for use as a solution of aromatic substances for aerosol inhaler designed for aerosol formation during heating and spraying of a solution of aromatic substances by inhalation by a user, to allow the user to "accept" the aerosol together with air, in particular for aerosol inhaler to simulate Smoking.

The level of technology

Aerosol inhalers of this type are disclosed, for example, in Japanese published patent application No. 2000-510763 PCT and in Japanese patent No. 3484233 and No. 3488717. The aerosol inhalers disclosed in these publications, use appropriate different ways of spraying aromatic substances for aerosol formation. More specifically, in the inhaler described in Japanese published patent application No. 2000-510763 PCT, the solution of aromatic compounds containing an aromatic substance, is heated to spray. In the inhaler described in Japanese patent No. 3484233, on the solution of aromatic substances act ultrasonic waves to spray, and inhaler described in Japanese patent No. 3488717, the solution of the aromatic substance is sprayed in the form of spray.

Detailed description of the invention

Problems to be solved by the inventions

Whichever way nor used in the above three aerosol inhalers for spraying of a solution of aromatic substances, the relative amount of the aromatic component in the formed aerosol, namely the efficiency of aerosol formation from aromatic component is low. Accordingly, when the inhalation aerosol together with air, the user cannot fully absorb converted into aerosol aromatic component, i.e. the aromatic substance aromatic spray.

Besides the aromatic aerosol has low stability. Thus, in cases where the aromatic aerosol inhaled to simulate Smoking, aromatic aerosol disappears immediately after its introduction into the oral cavity of the user. The user, therefore, can not long to feel incense aromatic aerosol, in contrast to the usual process of Smoking cigarettes.

The aim of the present invention, therefore, is the provision of a liquid to form an aerosol for use in an aerosol inhaler, where this fluid can be used to form a substantial amount of aromatic aerosol, and to provide the opportunity for the user prodlem the th time feeling aromatics aromatic aerosol entered in his mouth.

Solutions to problems

To achieve the goal proposed by the present invention, the liquid for aerosol formation for use in an aerosol inhaler, where liquid for aerosol formation contains the basic components comprising the solvent and a lipophilic aromatic substance dissolved in the solvent, and a carboxylic acid, added to the principal components, where the carboxylic acid has a value of vapor pressure component from 1x10-9to 20 mm Hg at a temperature of 25C.

Preferably the proportion of carboxylic acid is 10 wt.% or less by weight of the main component, and the carboxylic acid is one or more compounds selected from the group consisting of acetic acid, tartaric acid, adipic acid, citric acid and lauric acid.

If the liquid to aerosol formation use in an aerosol inhaler and if the user inhales it in the form of aromatic aerosol, through the carboxylic acid contained in the liquid for aerosol formation, provide the conditions under which the liquid to aerosol formation has increased ability to form aerosol and received aromatic aerosol is more stable than liquids for clicks is increased aerosols, not containing carboxylic acid.

More specifically, the main components include propylene glycol as solvent and L-menthol as aromatic substances. In this case, the liquid aerosol formation suitable for the simulation area.

Advantages of the invention

When using liquid for aerosol formation for pseudocumene of the fluid can effectively form an aromatic aerosol with a large lifetime. As a result, the user gets the opportunity to experience the aroma and taste aromatic spray in his mouth, and he can get pleasure from the simulation area, very similar to the feelings experienced when Smoking regular cigarettes.

Brief description of drawings

In Fig. 1 is shown as an example aerosol inhaler (in section), which is used for testing; and

in Fig. 2 - diagram of the attenuation coefficients of the captured light when passing through the aromatic aerosols over time.

The best way of carrying out the invention

Liquid for aerosol formation for use in an aerosol inhaler contains the core components and the carboxylic acid is introduced as an additive to the main components. More specifically, the OS is ESD components contain a solvent and a lipophilic aromatic substance, dissolved in the solvent and the carboxylic acid is characterized by the magnitude of the vapor pressure component from 110-9up to 20 mm RT. tbsp. at a temperature of 25C.

It is desirable that the proportion of carboxylic acid was 10 wt.% or less, preferably 3 wt.% or less, by weight of the main components. Carboxylic acid to be used may be one substance selected from the group consisting of acetic acid, tartaric acid, adipic acid, citric acid and lauric acid, or may be a mixture of two or more of these acids.

Examples

Preparing the liquid A-F, the composition of which is given below, for the formation of aerosols.

All these fluids A-F for the formation of aerosols contained as main components: propylene glycol as the main solvent and L-menthol as a lipophilic aromatic substances. Fluids A-E for the formation of aerosols contained, respectively, acetic acid, tartaric acid, adipic acid, citric acid and lauric acid as a carboxylic acid, while the liquid F for aerosol formation contained only the above-mentioned main components.

Table 1 below shows the corresponding compositions of fluids A-F for the formation of aerosols.

Table 1
AInDEF
Propylene glycol (wt.%)656572656575
L-menthol (wt.%)252525252525
Acetic acid (wt.%)1000000
Tartaric acid (wt.%)0100000
Adipic acid (wt.%)003 000
Citric acid (wt.%)0001000
Lauric acid (wt.%)0000100

The following tests 1-3 using the above liquids A-F for the formation of aerosols were performed to compare the ability to aromatic aerosols from the respective liquids, and to compare the duration of existence, scents and tastes of the corresponding aromatic aerosols.

Test 1

Using an aerosol inhaler shown in Fig. 1, each of the liquids C and F for the formation of aerosols, supplied in a predefined amount at a time (e.g., 2 mg)was converted into an aerosol and aromatic aerosol produced from the mouthpiece of the inhaler, was collected using a filter. Then determined the ratio of the number of liquids C andFfor the formation of aerosols collected by the filter, to the number of pod is different liquids C and F, accordingly, i.e. the efficiency of the Cathedral of the liquids C and F for the formation of aerosols. The results are presented in Table 2 below.

Table 2
F
Collection efficiency72%66%

From Table 2 it follows that the collection efficiency of the liquid C for aerosol formation containing adipic acid as the carboxylic acid, is higher than the efficiency of collecting the liquid F for aerosol formation, not containing adipic acid. This means that the ability to form aerosol from the liquid C for aerosol formation, i.e. the ability to form aerosol aromatic substances above that of the liquid F for aerosol formation.

In Fig. 1 shows a spray pump 1, which were used to conduct the above Test 1. Below is a brief description of the inhaler 1.

The inhaler 1 includes a housing 4, which contains the mouthpiece 2, extending from its rear end. The housing 4 further comprises an inlet opening 6 for the intake of external air is formed in the outer surface of its distant end of the second part, and channel 8 for aerosol formation, formed therein. Channel 8 for the formation of aerosol passes from the inlet 6 to the intake of outdoor air to the mouthpiece 2.

Part of the channel 8 for aerosol formation presents a tubular electric heater 10, located inside the housing 4. The heater 10 is electrically connected to the circuit 12 of the power supply contains a power switch 14. When turning on the power switch 14 to the circuit 12 of the power supplied electric current to the heater 10 to raise the temperature of the heater 10 to a predetermined temperature.

In case 4 posted by syringe pump 16 of cartridge type. The syringe pump 16 includes a piston 20 located in the cylinder 17 of the syringe pump, and the piston 20 restricts the chamber 18 of the pump inside the cylinder 17 of the syringe pump. The rod 22 of the piston screw-type is connected to the piston 20 by means of ball joint 21. The rod 22 of the piston passes through the partition wall 19 of the cylinder 17 of the syringe pump, and the shaft is supported rotatably by a partition 19.

In addition, the rod 22 of the piston is connected via a rotary Cam 24 and a return spring 26 with the push button 28, containing the stem 30 of the pusher. The stem 30 of the pusher acts on the push button 28 to swing the fist 24 and contains the pusher 32 at its distant end. Each time you press, and is eaten release push button 28, i.e. click on the stem 30 of the pusher, the pusher 32 advance the piston 20 in the chamber 18 of the pump at a predetermined distance at a time, with simultaneous rotation of the Cam 24, thereby reducing the volume of chamber 18 of the pump.

Channel 34 for fluid passes from the chamber 18 of the pump to the channel 8 for aerosol formation and meets with the channel 8 at the connection point X, located upstream from the heater 10. Accordingly, when pressing the push button 28 and vacations (when the camera 18 of the pump and the channel 34 for liquid filled with a solution of L, namely liquid C or F for aerosol formation) the number of solution of L corresponding to the distance by which to move the piston 20, serves to connect X channel 8 for aerosol formation.

When the user sucks the air in the channel 8 for aerosol formation, i.e. makes a puff through the mouthpiece 2, the outside air enters the channel 8 for aerosol formation through the inlet opening 6 for the intake of outside air, resulting in channel 8 for aerosol formation is formed by a stream of sucked air. The stream of sucked air generated thereby moves the solution L from the link X to the heater 10. When reaching the heater 10 L solution is heated and sprayed heater 10, into aromatic spray. Aromatic Aer the Sol is then released to the outside of the mouthpiece 2, together with the sucked air.

The amount of solution L, which served at once to the compound X was, as mentioned above, 2 mg of the Mouthpiece 2 of the inhaler 1 has been connected to the automatic Smoking machine (not shown)designed to perform the aforementioned operations of the suction air, i.e. tightening.

Test 2

Each of the liquids A-F for the formation of aerosols was poured into the nebulizer 1, shown in Fig. 1, and then, using an automatic Smoking machine produced using the inhaler 1 ten puffs so that the aromatic aerosol can be released from the inhaler 1. Aromatic aerosol, corresponding in number to ten puffs, caught the hermetic chamber. Then the aromatic aerosol captured hermetic chamber, irradiated by a laser beam for measuring the intensity noise of the laser beam, namely, the time variation of the attenuation coefficient noise of the laser beam.

In Fig. 2 shows curves Da-Df, corresponding to the attenuation coefficients in time captured light when tested aromatic aerosols Ca-Cf. Aromatic aerosols Ca-Cf were obtained from liquids A-F for the formation of aerosols, respectively.

From the analysis of Fig. 2 it is obvious that the coefficients of attenuation of light when passing through the aromatic aerosols Ca-Ce low is e, in comparison with the attenuation coefficient of light when you pass it through the aromatic aerosol Cf. This is confirmed by the fact that aromatic aerosols Ca-Ce exist over a longer period of time than the aromatic aerosol Cf.

Test 3

Tasters breathed in each of the aromatic aerosols Cc and Cf using the inhaler 1, shown in Fig. 1, to assess aromatic aerosols Cc and Cf. Evaluation of the test results were as follows.

When testing the aromatic aerosol Cf felt a strong irritant effect from L-menthol in the mouth. On the other hand, when testing the aromatic aerosol Cc tasters felt irritant effect from L-menthol in the area from the mouth to the posterior pharyngeal wall, and when testing the aromatic aerosol Cc when you exhale still felt irritant effect from L-menthol. This indicates that the aromatic aerosol Cc, obtained from liquid to aerosol formation, has longer existence, in comparison with aromatic aerosol Cf obtained from the liquid F for aerosol formation.

1. Liquid for aerosol formation for use in an aerosol inhaler, where aerosol inhaler is intended for aerosol formation by heating and spraying of a solution of aromatic ve is esta during inhalation and to enable inhalation aerosol together with the sucked air flow where the liquid to form an aerosol that is used as a solution of aromatic substances, contains:
the main components comprising the solvent and a lipophilic aromatic substance, which contains L-menthol dissolved in the solvent, where the solvent contains propylene glycol; and
- adipic acid, added to the basic component.

2. Liquid for aerosol formation according to claim 1, in which the proportion of adipic acid is 10 wt.% or less by weight of the liquid to aerosol formation.

3. Liquid for aerosol formation according to claim 2, in which the proportion of adipic acid is 3 wt.% from the mass of liquid for formation of the aerosol.

4. Liquid for aerosol formation according to claim 3, which contains 72 wt.% propylene glycol and 25 wt.% L-menthol.



 

Same patents:

FIELD: temporary layout and differentiation of controlling distances on playgrounds and fields suitable for sport.

SUBSTANCE: foaming aqueous composition containing at least one non-ionic surfactant or amphoteric surfactant as foaming agent, and at least one amphoteric surfactant as foam control agent, is sprayed on playground or field. Said non-ionic surfactant represents ethoxylated vegetable oils; amphoteric surfactant as foaming agent represents alkyldimethylamine oxide; and amphoteric surfactant as foam control agent represents betaines in combination with at least one propellant. Composition of present invention is useful in layout and differentiation of controlling distances on playgrounds and fields, in particular football fields.

EFFECT: method with improved effectiveness.

19 cl, 3 ex

The invention relates to the production of propellants and compositions on their basis

The invention relates to a technology for environmentally friendly hydrocarbon gases, propellants,

The invention relates to aerosol compositions, in particular to the propellants for aerosol packages used in household chemicals

FIELD: tobacco industry.

SUBSTANCE: invention relates to the process of biologically active and/or aromatic substances volatilisation for purposes of inhalable aerosol extraction in the course of the smoker imitating the act of a regular cigarette smoking. Gaseous products of combustion of flammable gas burnt (preferably - under oxygen excess conditions) partly or wholly, are supplied (in case of necessity - mixed with ambient air) through the biologically active and/or aromatic substances depot. The desirable temperature is selected by the gaseous combustion products content, in case of necessity - by the components ratio of the mixture of such gaseous combustion products with ambient air. The device for the method implementation includes a mouthpiece containing the biologically active and/or aromatic substances depot and a heating core. The core contains the body shell, a filling valve for filling a tiny gas reservoir with flammable gas, a regulator valve for controlled discharge of gas from the gas reservoir onto the burner and the substance converter for air heating with thermal energy generated by the burner. The mouthpiece is connected so that to enable its disconnection from the cigarette- or cigar-shaped heating rod for output of inhalable aerosol. Control of the regulator valve is performed by means of depression suction provided for on the mouthpiece and/or by means of air flow.

EFFECT: new smokeless cigarette substitute is proposed.

19 cl, 11 dwg

Evaporating device // 2425608

FIELD: heating.

SUBSTANCE: device for supply of evaporated material to consumer includes heat transfer element which includes heat sink having thermal coupling to heat exchanger, for example to heat tube, and evaporator which includes source of material capable of evaporation, for example tobacco, aromatic material or therapeutic substance. Evaporator is installed on heat transfer element in detachable way. Source of material capable of evaporation has thermal coupling to heat exchanger of heat transfer element. Heat transfer element can be reused with non-reusable evaporators.

EFFECT: owing to design of evaporating device, which is provided with possibility of being isolated from heat exchangers, such evaporating devices can be fabricated and sold separately from heat exchanger, and heat exchangers can be reused.

26 cl, 11 dwg

FIELD: personal use articles.

SUBSTANCE: cigarette substitute comprises hollow tubular element equipped with generator of inhaled substances, inner heating facilities for heating of inhaled air or at least part of inhaled substances generator, and device of inhaled substances generator start-up. Start-up device comprises element, which is sensitive to effect of heat produced by heating facilities arranged outside substitute independently on it. Specified heat-sensitive element is made from material, which is not ignited or does not glow under conditions of normal usage of substitute.

EFFECT: invention provides for harmless usage of device with full imitation of real smoking process.

28 cl, 1 dwg

FIELD: personal use articles.

SUBSTANCE: carbon-bearing composition is intended for heater of incombustible smoking material. Heater composition contains coal and polyatomic alcohol. Smoking material of incombustible type comprises aerosol-generating section, where aerosol is produced in process of heating, and a heater at the end of aerosol-generating section. Heater is arranged so that it is physically separated from aerosol-generating section for substantial heating of this section without ignition of aerosol-generating section. Heater consists of above-mentioned composition.

EFFECT: increased amount of aerosol with reduction of carbon monoxide amount, and also improved ignition time.

8 cl, 2 dwg, 2 tbl, 4 ex

FIELD: tobacco industry.

SUBSTANCE: invention relates to devices for smoking simulation. Tobacco pipe for smokeless smoking contains bowl, chibouk, cigarette holder with mouthpiece and air channel inside the pipe, in which it is located carrier of nicotine-bearing substance and/or aromatiser and heating facility, connected to current source. At least, one of heating facility elements is located in cigarette holder and displaced to its mouthpiece.

EFFECT: invention provides ability to smoking unhook for pipers.

30 cl, 7 dwg

FIELD: tobacco industry.

SUBSTANCE: proposed is a carbon-bearing compound for fabrication of a non-combustible smoking product heating element. The compound contains calcium carbonate in an amount required for maintenance of the combustion temperature within the standard smoking range (1000C max). Particle diametre of the calcium carbonate used varies from 0.08 mcm to 0.15 mcm. Additionally the compound contains a bonding agent in an amount specified.

EFFECT: reduced carbon monoxide emission during the smoking product heating element combustion.

4 cl, 2 dwg, 2 tbl, 10 ex

Tobacco usage mode // 2329748

FIELD: alimentary products, tobacco.

SUBSTANCE: suggested mode of tobacco usage consists in inhaling its aqueous extract produced when a heated gas mixture comes in contact with liquid extract. The latter fills the cavities and splits formed by the filler granules. Heated gases come in contact with the tobacco extract inside a vertical tube made of a fire-resistant material with its lower butt-end covered with net. The net is used for sucking heated gas mixture inside the tube and discharge of the extract overstock. The tube contains filler that is regularly imbibed with tobacco extract poured inside through the upper butt end. The heated gas mixture becomes sucked inside the pipe due to pressure differential resulting from the user inhaling the end product through the upper butt end.

EFFECT: reduced formation of toxic agents during smoking.

7 cl, 3 dwg

FIELD: tobacco products.

SUBSTANCE: pipe for simulation of smoking comprises a shank integral with a bowl and a bit separable from the shank and fitted with a mouthpiece. In the smoke passage between the shank and the bit there is a hollow space intended for placing therein a sealed capsule with a nicotine-containing substance or a flavour. In front of the capsule in the smoke passage there is an electric heater connected to a current source placed into the bowl walls.

EFFECT: invention ensures preservation of the health of a pipe smoker while fully simulating the process of smoking.

17 cl, 8 dwg

Inhaler // 2311859

FIELD: medicine.

SUBSTANCE: inhaler has catalytic burner, fuel balloon 6 containing hydrogen, said balloon being connected to burner, reservoir 15 for inhaling additives such as aromatic substances and/or functioning substances, at least one inlet 2 for oxygen-containing gaseous mixture, preferably for air, and at least one outlet 3 for inhaling mixture containing aromatic substances and/or functioning substances.

EFFECT: increased efficiency and convenient usage of inhaler.

13 cl, 1 dwg

FIELD: artificial smoking articles, in particular, holders for artificial smoking articles.

SUBSTANCE: holder has casing with front part made from low thermal conductivity material, air feeding means for providing inflammation of gaseous fuel, fuel mixture chamber, and rear tubular part made from high thermal conductivity material. There are fuel means provided in front tubular part of casing and adapted for feeding of gaseous fuel. Fuel mixture chamber is communicating with said fuel feeding means and air feeding means. There is chamber in rear portion of tubular part, wherein cigarette is to be inserted. Flame keeping device is positioned behind fuel mixture chamber, before combustion chamber positioned between flame keeping device and chamber where cigarette is to be inserted. Flame is formed in combustion chamber. Spark igniter is also positioned in tubular portion of tubular part, behind flame keeping device, in the vicinity of combustion chamber.

EFFECT: increased efficiency and reliable holding of artificial smoking article.

21 cl, 5 dwg

FIELD: tobacco industry.

SUBSTANCE: invention relates to a method for production of non-smoking products of rustic tobacco. The method involves preparing recipe ingredients, extracting Chinese magnolia vine fruits with liquid carbon dioxide with corresponding miscella separation, cutting rustic tobacco and scorzonera, drying them in a microwave field at preset process parameters. Then one performs their blending, impregnation with separated miscella with simultaneous pressure boost, depressurisation to atmospheric value with simultaneous freezing of the mixture, subliming and removal of carbon dioxide with simultaneous swelling of the mixture. Then one adds apple juice concentrate, sugar syrup, calcium and/or magnesium citrate and water to the mixture and moulds the produced mixture to produce the target product.

EFFECT: method allows to produce a new non-smoking nicotine-containing rustic tobacco product with improved organoleptic properties and extended storage life combined with decreasing losses of flavouring substances and initial raw material nicotine.

1 ex

FIELD: tobacco industry.

SUBSTANCE: invention relates to a method for production of non-smoking products of rustic tobacco. The method involves preparing recipe ingredients, extracting peppermint with liquid carbon dioxide with corresponding miscella separation, cutting rustic tobacco and scorzonera, drying them in a microwave field at preset process parameters. Then one performs their blending, impregnation with separated miscella with simultaneous pressure boost, depressurisation to atmospheric value with simultaneous freezing of the mixture, subliming and removal of carbon dioxide with simultaneous swelling of the mixture. Then one adds apple juice concentrate, sugar syrup, calcium and/or magnesium citrate and water to the mixture and moulds the produced mixture to produce the target product.

EFFECT: method allows to produce a new non-smoking nicotine-containing rustic tobacco product with improved organoleptic properties and extended storage life combined with decreasing losses of flavouring substances and initial raw material nicotine.

1 ex

FIELD: tobacco industry.

SUBSTANCE: invention relates to a method for production of non-smoking products of rustic tobacco. The method involves preparing recipe ingredients, extracting peppermint with liquid carbon dioxide with corresponding miscella separation, cutting rustic tobacco and scorzonera, drying them in a microwave field at preset process parameters. Then one performs their blending, impregnation with separated miscella with simultaneous pressure boost, depressurisation to atmospheric value with simultaneous freezing of the mixture, subliming and removal of carbon dioxide with simultaneous swelling of the mixture. Then one adds mango juice concentrate, sugar syrup, calcium and/or magnesium citrate and water to the mixture and moulds the produced mixture to produce the target product.

EFFECT: method allows to produce a new non-smoking nicotine-containing rustic tobacco product with improved organoleptic properties and extended storage life combined with decreasing losses of flavouring substances and initial raw material nicotine.

1 ex

Up!