Method of orthopedic treatment of women after post-menopausal period by means of removable plate dentures
SUBSTANCE: invention relates to medicine, namely to dentistry, and can be used in orthopedic treatment of women in post-menopausal period in case of complete or partial defects of dentitions by means of removable plate dentures. For this purpose cream "Ovestin" is applied on surface of denture basis in thin uniform 0.5-1.0 mm thick layer. Treatment is carried out daily once during 10 days from the moment of application.
EFFECT: method also ensures reduction of bleeding, keratinisation, improvement of microcirculation in mucosa of denture bed and as a result acceleration of socially-psychological adaptation of said contingent of patients.
2 dwg, 1 ex
The invention relates to medicine, namely to the dentist, and can be used in orthopedic treatment of women in postmenopausal period with complete and partial defects of dentition removable laminar dentures.
The result is a genetically determined deficiency of synthesis and secretion of hormones in women in the postmenopausal period processes characterized by disorders of metabolism, functions of tissues and organs, including dental system. Disorders caused by deficiency of estrogen in women in this period of life, and are characterized by changes in the mucous membrane, which appear thinning, atrophy of the epithelium and the development of inflammation. These circumstances may have an adverse impact on the adaptation of women to removable laminar dentures.
There is a method of orthopedic treatment of women with postmenopausal period removable laminar dentures with the use of biopolymer films with immunocorrector "Imudon" for the period of adaptation, which consists in placing elastic film on the basis removable laminar denture after carrying out personal hygiene activities (Calibration AS assessment of the effectiveness of drug films with immunocorrector in removable prosthetics / Calibration AS, prima is eve, NV, Leshcheva E.A. and others // the Institute of dentistry. - 2010. No. 1. - P.40-41).
The disadvantage of this method is quite rapid elimination of the drug from the mucous membranes of the oral cavity, resulting in a need frequent use 2-3 times a day, lasting 7-10 days, then 2-3 times a week for 14 days, and shallow penetration "Imudon" in the mucosa of the prosthetic bed because of hemodynamic disorders in it.
Closest to the claimed invention, the achieved result is a method of orthopedic treatment of women with postmenopausal period by use of adhesive means "Tizol with propolis" (LLC "Olympus", Russia, RF patent №2177304). To improve the fixation of removable laminar dentures composition is applied with a brush to clean the locking surface of the removable laminar denture, thereby increasing the fixation and stabilization of the latter, which contributes to the reduction of terms adaptation (Zheludev S.E. Adhesive means in prosthetic dentistry. - M: Medical book. "Dentistry", 2007. - s).
Along with the positive effects from the use of the specified adhesive means having a bacteriostatic, local anesthetic, dermatophytosis and antiviral effect due to included in his SOS is AB propolis, there are several disadvantages, among which is an allergic reaction to the components of the material and the lack of prevalence of this drug on the market. In addition, the disadvantage of this method is the lack of influence on the pathogenetic links of postmenopausal dental disorders in women related to estrogen deficit.
The authors proposed a method of orthopedic treatment of women with postmenopausal period removable laminar dentures, by local application of cream "Avastin" under the prosthesis basis.
The technical result of the proposed method is to increase the efficiency of the orthopedic treatment of women with postmenopausal period removable laminar dentures due to local use of estrogens.
The technical result is achieved in that on the inner surface of the prosthesis basis is applied in a thin uniform layer of 0.5-1.0 mm cream "Ovestin daily and once daily for 10 days after overlay dentures.
The way the orthopedic treatment of women with postmenopausal period removable laminar dentures demonstrated by figures 1 and 2. The figure 1 presents the dental formula of the patient H. The figure 2 presents the form completed by the patient N.
The method is as follows.
Women who m the early postmenopausal period of life (age from 49 to 55 years), previously not using removable laminar dentures prescribe the drug "Avastin".
The drug "Avastin" (JSC Organon OSS, the Netherlands) apply after carrying out hygienic measures in the oral cavity and cleaning of dentures, spot applied on the inner surface of the prosthesis basis and evenly distribute a thin layer of 0.5-1.0 mm on it. Treatment once daily for the first 10 days after imposition of removable laminar dentures. "Avastin" - oestriol drug short duration. Causes increased proliferation of the epithelium, stimulates blood flow, promotes restoration of the epithelium when it is atrophic changes and increases the resistance of the epithelium to infectious and inflammatory processes.
The treatment by the present method.
Patient P., 50 years old, came on 14 September 2010 with the aim of rational prosthetics.
Complained of partial absence of teeth, difficulty chewing food, the diction and phonation.
Moved and comorbidities according to the patient: hepatitis, tuberculosis, sexually transmitted diseases was not sick. Allergic anamnesis is not burdened. Conducted surgery for uterine fibroids in 2002 (surgical Meno is Naoussa).
The development of this disease: teeth removed gradually, the last about three weeks ago. Removable laminar dentures have not used.
External examination: the severity of nasolabial and chin creases, slight decrease in the height of the lower part of the face.
The figure 1 presents the dental formula of the patient N.
In the mouth: mucous pale pink color, with no visible pathological changes. 2.3 previously were under the crown. Artificial plastic crown 2.1, 2.2 do not perform anatomical shape of the teeth and do not reach the edge of the gum 1-1,5 mm Artificial stamped crown 4.7 with lots erase decorative spray does not reach the gingival margin by 0.8-1 mm, the mobility of the first degree.
Diagnosis: partial absence of teeth on the upper jaw 1 class on Kennedy; partial absence of teeth on the lower jaw 2 class 3 sub-Kennedy; irrational artificial plastic 2.1, 2.2 and stamped steel with decorative plating 4.7 crowns.
Treatment: cutting and removal of artificial plastic corank 2.1, 2.2 and pressed crown 4.7; made new artificial plastic crown on 2.1, 2.2, 2.3 and 4.7. Prosthetic treatment of partial absence of teeth on the upper and lower jaws were carried out in the traditional way of partial removable laminar zu the different prostheses.
After applying removable laminar dentures were prescribed course of Ovestin" within ten days. The drug was applied once daily to the internal surface of the prosthesis basis and uniformly distributed on it.
The survey was carried out before application of prostheses, two weeks, one and three months.
In addition, the patient throughout the period of observations were made of the data in the questionnaire (figure 2), which allowed to judge the timing of adaptation to removable laminar dentures.
Local application of estrogen when using removable laminar dentures had a beneficial effect on tissue prosthetic bed, leading to lower values papillary-marginal-alveolar (PSE) index to two weeks of use of the prosthesis, which amounted to 8.3% and its stabilization to the first month of observations of 8.3% compared to the original level, equal to 16.6%. Despite the irritating removable laminar dentures on periodontal tissue topical application of 0.1% cream estriol after applying prostheses contributed to the decrease of the values of the index bleeding gums on Meuleman(points) by the second week of 0.25 compared with outcomes equal to 0.75 and stabilization of the examined indicator to the first month of observations, amounting to 0.25. The results of cytological examination testified about what sileni the degree of maturation of epithelial cells with 425 units up to 456 units to the month of observation and reduction index values of keratinization with 78% in Exodus up to 70% - to-month observations. The results of ultrasonic Doppler flowmetry microvasculature of the mucous membrane of prosthetic bed showed a positive trend of increased perfusion of the tissue by the second week of observation at all control points, equal 21,95 PF. units with respect to the original value, which amounted to 17,28 PF. unit, and stabilization of the index-to-month observations 21,02 PF. units
Analysis of the questionnaires filled out by the patient, testified to the onset of full adaptation to removable laminar dentures to the thirteenth day of wearing dentures, which allows to judge about the high efficiency of the proposed method.
The claimed method treated 18 patients with a good clinical result.
Thus, the claimed method has a high efficiency because the local application of estrogen in women with postmenopausal period under the bases removable laminar dentures leads to improved clinical and laboratory indices of tissue prosthetic bed and shortening of adaptation.
The advantage of the proposed method over the known is that the inventive method has a positive effect on the condition of the gums, mucous membrane prosthetic bed and helps reduce the structure of terms adaptation removable laminar dentures in women of postmenopausal age. And this in turn can have a positive effect not only on increasing the comfort when using the prosthesis, but also on the acceleration of socio-psychological adaptation of this contingent of patients.
The way the orthopedic treatment of women with postmenopausal period removable laminar dentures by applying a therapeutic agent, characterized in that on the inner surface of the prosthesis basis is applied in a thin uniform layer of 0.5-1.0 mm cream "Ovestin daily and once daily for 10 days from the date of imposition of prostheses.
FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to pharmaceutics and medicine, and concerns application of sophoricoside.
EFFECT: preparing the drug applicable for preventing and/or treating articular cartilage degeneration or osteoarthritis in postmenopausal females, exhibiting side-effect-free high efficacy.
6 cl, 11 dwg, 5 tbl, 7 ex
SUBSTANCE: invention relates to field of medicine, namely to gynecology, and can be used in treatment of patients with climacteric syndrome of various severity degree. Method includes daily carrying out transcranial electric stimulation (TES) of brain protective mechanisms with constant current with intensity 1.5-2.5 mA, duration 20-30 minutes and introduction of medication "Sagenit". After carrying out each third TES session electric encephalogram is registered. If α-rhythm amplitude decreases lower than 30 mcV, TES sessions are not resumed. Treatment is continued by introduction of medication "Femoston 1/10" daily in dose 1 tablet per day during 2-3 weeks until amplitude of α-rhythm is restored above 30 mcV, with further introduction of medication "Sagenit" in dose 1 tablet per day during 2-3 months. If reduction of α-rhythm amplitude does not take place, 9-15 sessions of TES are carried out with the following introduction of medication "Sagenit" daily in dose 1 tablet per day during 20-30 days.
EFFECT: method makes it possible to increase degree of patients' adaptation taking into account individual peculiarities of organism, reduce probability of development of negative side effects in process of climacteric syndrome treatment.
SUBSTANCE: invention relates to novel cyclohexylamine derivatives of formula (I), having inhibiting properties towards at least one monoamine transporter, such as serotonin transporter, dopamine transporter or norepinephrine transporter, or a combination of two or more transporters. The compounds can be used to treat and/or prevent central nervous system disorders such as pain, depression, anxiety, schizophrenia, sleep disorder etc. In formula (I) , n equals 0 or 1; s equals 1, 2 or 3, m equals a whole number from 0 to 12; Ar is
or where Y and Z are (i) both halogen; or (ii) one of Y and Z is CF3 or OCF3 and the other is hydrogen; Y1, Z1, Y2 and Z2 each independently denotes H or a halogen; each X independently denotes H, halogen, CF3, OR5, (C1-C4)alkyl, optionally substituted with halogen or OH, or NR6R7; each R1 and R2 independently denotes H or (C1-C6)alkyl; and each R3 and R4 independently denotes H or (C1-C9)alkyl optionally substituted with OH; where each R5 independently denotes H, (C1-C4)alkyl or phenyl; and each R6 and R7 independently denotes H or (C1-C4)alkyl; where at least two of R1, R2, R3, R4 and X together with atoms to which they are bonded are optionally bonded to form a 5-6-member ring, where the 5-6-member ring is selected from: a) R3 and R4 together with a nitrogen atom to which they are bonded optionally form a pyrrolidine, piperidine, piperazine or morpholine ring, which is optionally substituted with (C1-C4)alkyl; b) when R3 is H or lower alkyl, X and R4 together with atoms to which they are bonded optionally form a 1,3-oxazine ring; c) two X substitutes together with a carbon atom to which they are bonded optionally form a 1,3-dioxolane ring; and d) when R1 and R3 denote hydrogen, R2 and R4 together with atoms to which they are bonded optionally form a 5- or 6-member saturated heterocyclic ring containing one nitrogen atom.
EFFECT: high efficiency of using the compounds.
29 cl, 36 dwg, 11 tbl, 6 ex
SUBSTANCE: treating degree 1 discirculatory encephalopathy complicated by climacteric syndrome is enabled by a therapeutic course of systemic ozone therapy consisting of 5 intravenous drop infusions of ozonised 0.9 % sodium chloride at rate 8-10 ml/min. The procedures are daily in the ozone concentration in physiologic saline 400 mcg/l. A single ozone dose introduced in a vascular bed for one infusion is 160 mcg, a course dose is 800 mcg. Thereafter, the preparation Climadinone 30 drops or 1 tablet is prescribed depending on presentation daily 2 times a day for 3 months.
EFFECT: invention allows eliminating manifestations of estrogenic deficiency and neurological clinics that promotes pathology stabilisation and prevents progression of the diseases in the absence of by-effects.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to pharmacology and represents peroral composition, including L-arginine and R-α-lipoic acid in effective amount, where L-arginine is present in molar excess with respect to amount of R-α-lipoic acid present in composition.
EFFECT: invention ensures improvement or treatment of sexual disorders, both in males and females, without risk of side effects.
18 cl, 7 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of medicine and chemical-pharmaceutical industry, in particular, to solid therapeutic preparative form, which includes granulated materials, containing as therapeutically active compound, ospemifene, also known as (deaminohydroxy)toremifene, or its geometric isomer, stereoisomer, pharmaceutically acceptable salt, ester or metabolite, in combination with one or more intragranular excipients.
EFFECT: obtaining required medications.
2 cl, 1 dwg, 1 tbl, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed are monophase pharmaceutical composition, containing conjugated estrogen and hydrophilic or lipophilic excipient, where conjugated estrogen includes sodium estrone sulfate, sodium equilin sulfate, sodium 17α-dihydroequilin sulfate, sodium 17β-dihydroequilin sulfate, sodium 17α-estradiol sulfate, 17β-estradiol sulfate, sodium equilenine sulfate, sodium 17α-dihydroequilenine sulfate and sodium 17β-dihydroequilenine sulfate, where viscosity constitutes more than approximately 1 poise and less than approximately 30000 poise, containing single dose of said composition applicator, set of applicators and corresponding method of treating conditions in menopause.
EFFECT: increase of diffusion and flowing of estragens from claimed pharmaceutical compositions in comparison with premarin cream.
51 cl, 10 dwg, 8 tbl, 9 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to chemical-pharmaceutical industry, and deals with application of somastostatin or one of its agonistic analogues for manufacturing medication for regulation of follicular reserve of ovary or to application of antagonistic analogue of somastostatin for manufacturing medication for acceleration of beginning of resting follicle growth in women who do not have menopause yet.
EFFECT: reduction of depletion of ovarian follicular reserve in curse of time in women, who do not have menopause yet, as well as elaboration of means for determining impact of compounds on acceleration or retardation of follicle growth in carrying out toxicological tests.
16 cl, 3 ex, 5 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions relates to medicine, in particular to gynecology and deals with hormonal treatment of disease or disorder and increase of fertility in woman who needs it. For this purpose, regimens of continuous with more than 50-day duration introduction of combination of ethinylestradiole in dose from 5 mcg to 50 mcg and levonorgestrel in dose from approximately 0.05 mg to approximately 1.5 mg is suggested. Further, estrogen is introduced during period from 2 to 10 successive days.
EFFECT: due to "estrogen bridge" between cycles of hormonal therapy, inventions ensure reduction of number of unplanned bleedings in second and following cycles of intake in comparison with regimens, which include after the cycle finishing days, free of hormonal therapy, and minimisation of symptoms, conditioned by break between cycles.
64 cl, 10 dwg, 21 tbl, 10 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to a chemical-pharmaceutical industry, namely to creation of an antimenopausal drug. As an antimenopausal drug, dry extract of Amur maackia heartwood is applied.
EFFECT: drug relieves climacteric mental and vegetative-vascular disorders.
3 tbl, 11 ex
SUBSTANCE: invention relates to field of dental equipment and can be used in practical dentistry for treatment of dental canals. Device contains ultrasonic dental tip with nozzle, ultrasonic apparatus and system of ozonised solution supply. Tip is made with possibility of supplying ozonised solution to dental canal through nozzle. System of ozonised solution supply includes reservoir for obtaining ozonised solution, canal for supply of ozonised solution from hermetically closed reservoir to dental tip, canal for supply of ozone-oxygen mixture from ozoniser into reservoir, canal for discharge of ozone and oxygen mixture from reservoir back into ozoniser. One end of tube of canal for supply of ozonised solution from reservoir to dental tip is submerged into ozonised solution in reservoir, the other end being connected to first inlet of electromagnetic valve, through which ozonised solution is supplied to dental tip. One end of tube of canal for supply of ozone-oxygen mixture is connected to ozoniser, the other end is submerged into ozonised solution in reservoir. One end of tube of canal for discharge of air-ozone mixture from hermetically closed reservoir back into ozoniser is submerged into hermetically closed reservoir, which is located above the level of ozonised solution, the other end being connected to ozoniser destructor. Second inlet of electromagnetic valve is connected with two-way pedal for control of electromagnetic valve and ultrasonic apparatus operation.
EFFECT: application of invention makes it possible to increase efficiency and quality of treatment, reproducibility of obtained results, reduce expenditures on obtaining ozonised solution.
6 cl, 1 dwg
SUBSTANCE: under the conditions of modelling cirrhosis in experiment, the preparation EMBRYOBLASTE is introduced in liver tissue by means of an injector needle at the depth up to 0.1 cm. The preparation is introduced along a front surface of the liver, 2 injections in each lobe of the liver to form a papula. The volume of one injection makes 0.3 ml.
EFFECT: reduced fibrotic regeneration of liver tissue by means of intensifying liver cell proliferation and extracellular matrix resorption with reducing a degree of manifestation of venular and periportal fibrosis, reducing haemo- and lymphostasis, regenerating capillarisation of liver sinusoids without affecting cell architectonics of the organs.
4 tbl, 1 ex
SUBSTANCE: invention refers to devices for the application of art and identification tattoos on a human and animal body, and also for the intradermal introduction of drugs. A tattoo machine anchor assembly comprises an anchor, an anchor spring, a contact spring. The anchor is mounted on the anchor spring and oscillates. The anchor is hooked, and an upper end of the contact spring is brought under the anchor hook. Besides, the service life of single parts is prolonged.
EFFECT: invention provides higher operational stability of the tattoo machine, simplified setup and adjustment procedures.
SUBSTANCE: invention refers to medicine, namely to apparatuses for non-contact ultrasonic biotissue treatment and is applicable for the purpose of conservative therapy in various fields of clinical medicine. The apparatus comprises an ultrasonic generator and an acoustic system integrated in a bearing carrier and comprising a low-frequency longitudinal ultrasonic piezoelectric converter with an oscillation concentrator acoustically coupled with a radiator in the form of a disc-shaped waveguide representing a bent oscillating disc of a stepped section, and a reflector. A front emitting surface of an emitter comprises phase-compensating collars provided with radial circularly spaced threaded drainage spray orifices provided with cone nozzles, and also ring grooves alternating with the phase-compensating collars. On a back emitting surface of the emitter and opposite to the phase-compensating collars of the front emitting surface, there are connected shall-depth ring sockets coupled by radial slots. The washer reflector is integral with the back emitting surface of the emitter and forms the connected shall-depth ring sockets closed by ring ducts connected through a supply pipe system with a hydraulic system comprising an infusion unit with a medical solution.
EFFECT: using the invention enables functional enhancement ensured by non-contact ultrasonic treatment of biotissues of the greater area and surface irregularity both by a one-side uniform emission field of the greater area, and by ultrasonic aerosol spraying of the activated medical solution by a spray cone.
4 cl, 6 dwg
SUBSTANCE: invention relates to medical equipment, namely to instrument for introduction of transcutaneous sensor, which contains sensitive part, for instance, for registration of glucose in blood. Instrument for introduction of transcutaneous sensor contains case, sensor case, needle bush, spring element and bearing site. Case is provided with guiding means on its internal surface for guided travel of bearing site. Sensor case contains sensitive part, introduced under the skin. Needle bush contains needle for introduction for puncturing skin. Sensor case and needle bush are connected to each other in a separable way and in their connected state needle for introduction contacts with sensitive part. Bearing site on its internal surface is provided with guiding means which ensures guided travel relative to case between retracted and extended positions. Spring element is connected with trigger means. When trigger means is set into operation sensor case, needle bush and bearing site under the impact of spring element are put into extended position, in which needle and sensitive part can be introduced under the skin. Needle bush and bearing site are provided with inseparable means of fixation. Needle for introduction, at least partially, surrounds sensitive part, introduced under the skin. Introduced sensor of the said instrument for introduction can register glucose in patient's blood. In the second version of implementation of instrument for transcutaneous sensor, needle bush and bearing site are provided with inseparable means of fixation. Lower base of case is made with protruding part. Protruding part forms an angle with needle for introduction in longitudinal direction, setting for the person who introduces the needle the required angle in introduction.
EFFECT: instrument for introduction is simple and safe for user in the process of its application and removal after application.
18 cl, 27 dwg
SUBSTANCE: invention refers to medicine, namely to gynaecology, and can be used in integrated treatment of chronic inflammatory pelvic diseases. For this purpose with underlying integrated conventional therapy, including antibacterial therapy, a probiotic is administered. As a probiotic, a complex of alive strains of L.fermentum 39 and L.plantarum 8 PA 3 lactic acid bacilli containing 109-1011 CFU/ml of the alive strains of L.fermentum 39 and L.plantarum 8 PA 3 lactic acid bacilli in the ratio 1:1 in 1 ml. The probiotic is administered orally 5 ml once a day for 3-4 weeks and vaginally 5 ml in tampons for 2 hours for 2 weeks. The probiotic is administered in 2-3 hours after achieving the maximum blood antibacterial agent content. Treatment is performed with underlying lowcarbohydrate diet.
EFFECT: method provides higher clinical effectiveness and reduces length of treatment in the case patients ensured by improved urogenital and intestinal microbiocenosis.
2 cl, 4 tbl, 2 ex
SUBSTANCE: invention relates to medicine, namely to ophthalmology, and deals with treatment of hemorrhages which occur, for instance, at the background of age-related macular degeneration with subretinal neovascularisation. For this purpose courses of treatment are carried out in sessions, each of courses includes carrying out mydriasis of affected eye, puncture of sclera to vitreous body and alternate introduction of medications. At the first session introduced is medication which inhibits factor of vessel growth (MIFVG), fibrinolytic medication (FM) and medication of expanding gas (MEG), for instance, sulfur hexafluoride. At the second session, in case of hemorrhage, the same medications are introduced. If there is no hemorrhage at the second and following sessions only MIFVG is introduced. Simultaneously with puncture of sclera paracentesis of cornea is performed through which drainage of moisture, normalising intraocular pressure, is carried out. MIFVG dose is calculated depending on degree of retina edema, FM and MEG doses are selected proportionally to hemorrhage value determined during fundus examination. Single MEG dose constitutes 0.05-0.35 ml. After sessions, at which MEG is introduced for 1-1.5 weeks control over resolution process is performed and it is recommended to patient to preserve "face down" head position until gas is resolved completely. 10-15 seconds after introduction of all included into particular treatment session medications, needle is removed, interval between sessions is selected equal from 3 weeks to 1.5 months.
EFFECT: method increases treatment quality due to elaboration of specific regimen of impact of said treatment methods, which ensures not only elimination of hemorrhage but also leads to elimination of it causes with minimisation of traumatic factors of treatment.
SUBSTANCE: inventions relate to medicine, namely to cell transplantology, and deal with method and transplant for treatment of liver failure. For this purpose autologous progenitor cells of bone marrow are isolated and cultivated in vitro. Also realised is sampling of autologous liver cells. After that, immobilisation of autologous liver cells and progenitor cells of bone marrow on carrier - biodegradable biocompatible three-dimensional matrix is performed. After that, transplantation of carrier with cells is performed by its introduction into mesentery of small intestine. Transplant includes biodegradable biocompatible three-dimensional porous matrix with pore size 2-500 mcm and total porosity 50-97%, ensuring total concentration of liver cells and progenitor bone marrow cells 2×106-15×106 cells per 1 cm3 of matrix and ratio of progenitor bone marrow cells to liver cells from 1:1 to 1:4. Total volume of matrix constitutes not less than 0.05 cm3, its smallest linear size being not less than 0.2 mm.
EFFECT: inventions make it possible to improve results of liver failure treatment due to prolongation of terms of hepatocyte survival and activisation of their proliferation, creation of conditions for growing of vessels into creates carcass, diffusion of nutrients, oxygen and factors of tissue differentiation, make it possible to avoid application of immunosuppressive therapy.
6 cl, 6 dwg
SUBSTANCE: invention refers to medicine, particularly to percutaneous active substance delivery. A horny layer punching apparatus comprises an element provided with micro flanges having a skin contact surface and a variety of horny layer punching micro flanges on said surface. The apparatus is designed to enable the element provided with the micro flanges moving transversely in relation to a skin surface when contacting said skin.
EFFECT: ensured percutaneous drug delivery and penetration.
5 cl, 15 dwg
SUBSTANCE: invention refers to medical equipment, namely to biomechanical material injection, and more specifically to a device for high-viscosity material injection in a portion of a patient's body. The device for high-viscosity material injection in a cannula comprises a container, a pressing unit in liquid junction with the container, an overload valve for pressure balance in the device and a material moving element. The container is inextensible and has an outlet hole used for connection with the cannula for viscous material transportation. The pressing unit limits a fluid flow path through which an incompressible fluid is transferred. The material moving element cuts the fluid flow path and forms a section for incompressible fluid reception from its one side and a section for viscous material reception from the opposite side. The section for incompressible fluid reception is connected with the fluid flow path of the pressing unit for applying pressure. The section for viscous material reception is connected with the outlet hole of the container. The material moving element is movable under pressure of the actuating incompressible fluid to displace the viscous material from the section for viscous material reception of the container into the cannula. The viscous material injection device contains the inextensible body, material moving element, pressing unit and overload valve for pressure balance in the device. The material moving element divides the inextensible body on a first cavity having a first volume designed for incompressible fluid reception, and a second cavity having a second volume designed for viscous material reception. The material moving element is movable to change the first and second volumes in inverse proportion. The pressing unit for transferring the incompressible fluid into the first cavity which moves the material moving element for increasing the first volume and decreasing the second volume, thereby injecting the viscous material from the inextensible body. The container for the device for viscous material injection in patient's tissue comprises a proximal end, a distal end whereon an outlet hole for cannula connection and a flexible and inextensible package integrated in the container and designed for viscous material reception are provided. The package has a hole connected with the distal end of the container and connected with its outlet hole. The container is designed for receiving pressurised incompressible fluid surrounding the package, and thereby compressing the package and displacing the viscous material contained therein through the outlet hole of the container. The device for viscous material injection in patient's tissue comprises the inextensible container, the pressing unit in liquid junction with the inextensible container and the material moving element. The container has a proximal end with an inlet hole, a distal end with an outlet hole designed for connection with the cannula. The pressing unit is designed to generate pressurisation of the incompressible fluid. The pressing unit comprises a body and a power piston. The body has a fluid inlet, a fluid outlet and a fluid flow path created in between, at least one return valve in the flow path controlling fluid flow. The fluid outlet is designed in liquid junction with the container. The power piston is coupled with the body, by liquid junction with the flow path. The power piston is designed to provide a mechanical advantage by pressurising the fluid flow path when the incompressible fluid is transferred between the first and second positions. When movable to the second position, the power piston creates suction force transferring the incompressible fluid through the inlet. The return valve prevents reverse flow through the outlet back to the body. If returned to the first position, the power piston creates pressure transferring the incompressible fluid through the return valve from the body through the output and into the inextensible container. The material moving element divides the flow path between the inextensible container and pressing unit actuating the section of incompressible fluid reception and the section for viscous material reception. The material moving element is movable under pressure of the incompressible fluid inside the section of incompressible fluid reception to the outlet of the inextensible container, thereby displacing the viscous material from the section for viscous material reception into the cannula. In the second version of the device for viscous material injection into the cannula, the material moving element comprises a membrane elastically stretched under pressure of the actuating incompressible fluid.
EFFECT: invention provides mechanical advantage in viscous material injection.
49 cl, 14 dwg
SUBSTANCE: invention relates to substituted extratriene derivatives of general formula (values of radicals are given in the claim), useful in therapy, especially for treating and/or preventing steroid hormone-dependent disorders which require inhibition of 17β-hydroxysteroid dehydrogenase (17-HSD) enzyme type 1, type 2 and/or type 3, as well as salts thereof, pharmaceutical preparations containing said compounds, as well as methods of producing said compounds.
EFFECT: improved method.
41 cl, 98 ex