Method for restoration of haemostatic disturbances accompanying extremity fractures
SUBSTANCE: invention refers to medicine, namely traumatology, orthopaedics and leech therapy, and is applicable for the purpose of restoration of the haemostatis disturbances accompanying extremity fractures. That is ensured by applying the Ilizarov technique of transosseous osteosynthesis which is combined with leech therapy covering a skin projection of the fracture in the following schedule: one leech three times a week.
EFFECT: invention provides faster restoration of the microcirculation disturbances and stimulates the postoperative regeneration processes accompanying treating the extremity fractures.
1 dwg, 1 tbl, 2 ex
The invention relates to medicine, namely to traumatology, orthopedics and hirudotherapy, namely in the treatment of patients with trauma injuries for the correction of the hemostatic system.
Known methods of applying the treatment for various diseases and pathologies of the person, namely: a Method of treatment of scoliosis I-II degree (application No. 2005118228, publ. 2006.12.20), a Method of treating degenerative disc disease of the lumbar spine (application No. 2004122284, publ. 2006.01.27), a Method of treating osteochondropathy (patent No. 2195947, publ. 2003.01.10). The method of treatment of varicose veins (patent No. 2231360, publ. 2004.06.27), the Method of treatment of acute vascular optic neuropathy (patent No. 2281071, publ. 2006.08.10). Hirudotherapy is also used in the treatment of internal diseases as anti-inflammatory, anti-ischemic, anti-inflammatory agents, as well as to normalize the hemostatic indices (Ishkanian G.S. 1991, Savinov V. 2004, Kamenev O.Y 2006).
However, found in the sources we were not able to find information on the application of hirudotherapy in the treatment of patients with trauma injuries for the correction of the hemostatic system.
The present invention is to accelerate the restoration of microcirculatory disorders and stimulate regenerative processes in fractures of KOs is her limbs in the period of treatment by the method of transosseous osteosynthesis by Ilizarov.
The problem is solved in that in the method of recovering hemostatic disorders in fractures of the extremities, including the treatment method of transosseous osteosynthesis by Ilizarov, at the same time are leeching on the area of the cutaneous projection of the fracture mode: one leech three times a week.
The present invention is explained detailed description, clinical examples, a table and a picture showing an example of setting a leech on the area of the cutaneous projection of the fracture.
The method is performed in the following way.
In the postoperative treatment (2-3 days after the application of transosseous osteosynthesis) was added leeching mode: 1 leech 3 times a week on the area of the cutaneous projection of the fracture. The total number of sessions can range from 4 to 12 depending on the severity of the damage to the musculoskeletal system. The session lasts 20-40 minutes, leech utilized according to the requirements of the waste group C. On place attachment is applied with a cotton-gauze bandage on 14-16 hours.
Clinical observation restore hemostatic disorders in fractures of the extremities can be confirmed by a study.
For the past three months have seen a group of 60 patients with injuries of the musculoskeletal system. For the purity of ASCS is adowanie patients were divided into two groups. The average age of the patients 42,9±3.8 years, 38 men and 32 women.
In the first group of 32 people - the control group - leeching during treatment was not applied.
In the second group of 28 people - studied group during treatment was applied hirudotherapy (GT).
In the study group with 2-3 days after application of Ilizarov frame for 14-28 days used GT mode on one console leeches on the skin projection of the fracture three times a week (6-9 sessions). The duration of the session depended on the time of complete saturation of leeches. Leeches were used only once and subsequent disposal. After the procedure was applied with a cotton-gauze bandage.
The study of hemostasis was performed on hemocoagulase "Diagnostica STAGO" ("Technology standard", France), aggregometry "Aggregation analyzer ("Biola", Russia). To assess the validity of the differences of the results of the study and control groups used the parametric criteria student's t and Fisher.
The study of hemostasis groups (see table) revealed that the difference in treatment between the individual normal indicators of activated thromboplastin time (APCV) after injury and surgery was studied in a group of 1.46±1,09, in the control of 8.9±1,6 (p<0,01). The difference between normal prothrombin lie is neither (PV) in the study group 0,09±0,07, in the control - 2,2±1,3 (p<0,05). The level of fibrinogen in the treatment process is in the group of 4.4±0.7 g/l in the control of 5.7±1.1 g/l (p<0,01). The intermediate products of transformation and destruction of fibrin (; fibrin monomer complex) after surgical treatment was 12.7±4.4 mg/100 ml, decreased during treatment in the study group and 3.8±1.1 mg/100 ml in control only to 10.7±3.1 mg/100 ml (p<0.01) for the accepted norm of this indicator is less than 3.5 mg/100 ml
From this survey we can conclude that in the control group revealed hypercoagulation changes in agrigentum condition of the blood, such as hyperfibrinogenemia and expressed thrombinase. In the study group observed only easy thrombinase and indicators within normal limits".
These studies showed that the use of HT in the treatment of fractures of the method of transosseous osteosynthesis relieves post-traumatic tension coagulation and anticoagulation systems of blood and creates more favorable conditions for reparative processes, as evidenced by positive clinical dynamics.
Clinical example No. 1.
Patient I., aged 30. Medical card No. 1114 (28394). Came in with a diagnosis of Closed spiral fracture of the medial third of the right tibia and the lower third of the fibula offset the eating of fragments", operation: Closed transosseous osteosynthesis right tibia by Ilizarov".
In the postoperative observation period was added leeching mode: 1 leech 3 times a week on the area of the cutaneous projection of the fracture (the lower half of the tibia) total 4 sessions (see Photo). Duration of inpatient treatment was 23 days. The duration of the fixation period of 58 days. A gradual increase in load. Started to work after 70 days after injury.
Clinical example No. 2.
Patient P., aged 26. Case history No. 751 (70315). He admitted with a diagnosis of Closed spiral fracture of the lower third of the tibia and the upper third of the fibula of the right leg with displacement of fragments", operation: "Closed transosseous osteosynthesis right tibia by Ilizarov".
In the postoperative observation period was added leeching mode: 1 leech 3 times a week on the area of the cutaneous projection of the fracture (the lower half of the lower leg, foot) total 8 sessions. Duration of inpatient treatment was 18 days. The duration of fixation is 76 days. A gradual increase in load. Started to work through 116 days after injury.
The use of the proposed method in the clinic "RISC "RTO" them. Acad. Gailizarov" health District is hurt allows you to accelerate the restoration of microcirculatory disorders and to stimulate regenerative processes in the period of rehabilitation treatment for fractures of the extremities.
Method of recovering hemostatic disorders in fractures of the extremities, including the treatment method of transosseous osteosynthesis by Ilizarov, characterized in that at the same time are leeching on the area of the cutaneous projection of the fracture mode: one leech three times a week.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, more specifically pharmacology, and concerns an agent showing endothelium-protective activity. What is offered is a dry linseed extract as an agent preventing developing endothelial dysfunction.
EFFECT: agent extends the range of product showing endothelium-protective activity.
1 tbl, 3 ex
SUBSTANCE: group of inventions refers to medicine, and aims at improving blood circulation and relieving hypoxia symptoms accompanying various diseased conditions. There are offered oral drug preparations containing vitamin K2-7 (MK-7). Besides, the invention presents a pharmaceutical composition containing vitamin K2-7 (MK-7).
EFFECT: group of inventions provides improving blood circulation and reducing hypoxia.
14 cl, 1 tbl, 6 dwg, 12 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine and pharmacology, and represents a composition of high-molecular heparin and fish oil Eiconol exhibiting properties for oral application differing by the fact that it additionally contains leucine in the following amounts of the ingredients at 90-120 IU of heparin activity: leucine - 0.56-0.58 mg, Eiconol -113-115 mg.
EFFECT: invention provides more evident anticoagulant, anti-plate, fibrinolytic and fibrin depolymerisation action in single oral administration.
3 cl, 4 ex, 1 tbl
SUBSTANCE: what is offered is a solid dosage pharmaceutical composition containing a combination of acetylsalicylic acid and ethylmethyl hydroxypyridine malate and ethylmethyl hydroxypyridine succinate possessing antiaggregant, lipid-regulating and gastroprotective activities. What is shown is substantial prolongation of shelf life of the solid dosage form.
EFFECT: pharmacological and pharmacokinetic findings of the new composition make perspective in manufacturing of the solid dosage drugs for preventing and treating obesity, pathological conditions of the cardiovascular system, preventing ischemic disorders with manifested atherosclerosis, old infarction, ischemic stroke; peripheral artery disease.
SUBSTANCE: what is offered is application of 9-(3,4-dihydroxyphenacyl)-2,3-dihydroimidazo[1,2-a] benzimidazole hydrobromide of formula I as a compound possessing antithrombogenic activity. The compound is applicable as an active principle of drugs for therapy of thromboses. Activity of the compound exceeds acetylsalicylic acid and diabenol.
EFFECT: higher antithrombogenic activity in the conditions of arterial thrombosis.
2 cl, 6 tbl, 4 ex
SUBSTANCE: invention relates to a compound of general formula where R is a saturated linear or branched hydrocarbon chain of atoms. The compound is characterised by chemical selectivity with respect to thiol clusters of atoms and inhibits thrombocyte aggregation.
EFFECT: obtaining novel antiaggregants, capable of inhibiting the function of thrombocytes via a chemical reaction.
2 cl, 5 dwg, 2 tbl, 7 ex
SUBSTANCE: group of inventions refers to medicine and aims at blood coagulation inhibition in a human patient. It involves applying betrixaban or its pharmaceutically acceptable salts. Total daily dose makes 0.01 to 2.0 mg/kg.
EFFECT: group of inventions has an effect on thrombin formation and anti-Xa activity inhibition.
6 tbl, 12 dwg, 9 ex, 11 cl
FIELD: medicine, pharmaceutics.
SUBSTANCE: this invention relates to a compound ether of docosahexanoic acid and an alcohol, its production method and a pharmaceutical composition applied as a medication for prevention and treatment of cardiovascular diseases. The said alcohol is selected from pentanol with formula: and inositol with formula . The compound ether production method consists in transetherification of docosahexanoic acid ethyl ether with one of the said alcohols.
EFFECT: development of a pharmaceutical composition applied as a medication for production for cardiovascular diseases treatment and prevention.
10 cl, 5 tbl, 1 dwg, 5 ex
SUBSTANCE: invention refers to medicine, namely cardiosurgery, and may accompany endarterectomy with using extracorporeal circulation. That is ensured by the intracoronary introduction of heparin dissolved in normal saline in proportions 1:1 in dose 50-100 mg in a deendothelised area during pharmacological asystole.
EFFECT: method provides improved effect of said surgery ensured by the higher concentration of heparin absorbed on a vascular wall.
2 tbl, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to compounds of formula
and/or to all isomer forms of a compound of formula I, and/or to mixtures of these forms in any proportions, and/or to physiologically acceptable salts of the compound of formula 1, wherein R1 represents 1) -(C6-C14)-aryl-Z, wherein Z represents amino group, aminomethylene or amidino group, and wherein aryl is unsubstituted, 2) Het-Z, wherein Z represents amino group, aminomethylene or amidino group, and wherein Het is selected from benzimidazolyl and isoquinolinyl, and Het is unsubstituted or monosubstituted by group T, R2 and R4 are identical, and each represents hydrogen atom, R3 represents 1) -(C0)-alkylene-(C6-C14)-aryl, wherein aryl is unsubstituted or monosubstituted by group T, 2) -(C0)-alkylene-(C6-C14)-aryl-Q-(C6-C14)-aryl, wherein both aryls are unsubstituted, 3) -(C0-C4)-alkylene-(C6-C14)-aryl-p-Het, wherein aryl and Het in each case are unsubstituted, and Het represents piperidinyl, Q represents a covalent bond or -O-, T represents 1) halogen, 2) -(C1-C6)-alkyl wherein alkyl is unsubstituted, 3) -(C3-C8)-cycloalkyl or 4) -NO2, R5 and R6 are identical, and each represents hydrogen atom. Also, the invention refers to the use of the compound of formula I for preparing a drug.
EFFECT: there are prepared new compounds effective as blood coagulation factor IXA inhibitors.
6 cl, 2 tbl, 5 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmacological industry, particularly to a method for making a preparation of medicinal leech. The method for making the preparation of medicinal leech in which a leech is kept in an active fast regimen for at least 4 months, washed out, frozen and powdered to a homogeneous mass; the prepared mass is mixed with a water solution of polyvinyl alcohol and magnesium chloride in certain proportions and dried up in an environment avoiding any protein denaturation to elastic film formation.
EFFECT: method allows making the preparation of high anticoagulant and antichymotryptic activity and microbiological purity.
2 tbl, 2 ex
SUBSTANCE: method involves background chemotherapy and a complex of biologically active components, plant factors and beekeeping products, including honey 5 g 3 times a day, 20 % bee-glue butter 2 g 3 times a day, bear fat or seal fat 8 ml 3 times a day, aspen bark infusion 80 to 150 ml 3 times a day, vitamin tea 100 ml 3 times a day, fir oil once a day, guelder-rose and cranberry juice 50 ml 3 times a day, Iodine active 1 tablet a day; the complex components are taken by the following regimen: aspen bark infusion 1.5 hours before meals, bear fat or seal fat 1 hour before meals, bee-glue butter immediately after meals, honey and berry juice 1.5-2 hours after meals; the therapeutic course makes 84 days.
EFFECT: higher clinical effectiveness in lung tuberculosis ensured by normalising CD16-lymphocyte subpopulation and intensifying absorbing and bactericidal phagocyte function activated by the complex components.
3 cl, 2 tbl, 1 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, particularly to an agent for treating cardiovascular and cerebrovascular diseases. A method of preparing a therapeutic composition for treating cardiovascular and cerebrovascular diseases that involves selection of scorpion, centipede, eupolyphaga or steleophaga, leech, cicadas, ginseng root, prepared incense, peony root, sweet and white sandal wood, boras camphor and Ziziphi spinosae seeds according to the preset amounts, preparation of crude therapeutic extracts of said initial materials, agitation of the prepared extracts. A product of the therapeutic composition for treating cardiovascular and cerebrovascular diseases. A method of preparing the therapeutic insect extracts for treating cardiovascular and cerebrovascular diseases. The therapeutic insect extracts for treating cardiovascular and cerebrovascular diseases.
EFFECT: agents are effective for treating cardiovascular and cerebrovascular diseases.
11 cl, 2 tbl, 9 ex
SUBSTANCE: invention refers to medicine, particularly to reflexotherapy, and can find application in human body immunopotentiation. That is ensured by stimulating a stem cell growth area that is a sternum region. This is preceded with measurement and calculation of an average value of electric potential in skin points on an anterior part of body, aside from the sternum region, namely in the points located on a stomach in a projection of a small pelvis in the centre, to the right and to the left, in a projection above a kidney, a liver, a stomach, a pancreas, a bilious bubble. Separately, this value is measured in the sternum region in the points located along an average line in the centre of a presternum, at level of a fourth rib of a sternum body and in a zone of a xiphoid process. If observing the decrease of the potential value of the sternum as related to the average potential value of the anterior part of body, leech or bee treatment on the sternum is carried out for no more than 3 minutes followed check potential measurement. The treatment is repeated to balance the potential values or to exceed the potential value of the sternum over the average potential value of the anterior part of body.
EFFECT: method provides controlled stimulation of body immune system.
3 cl, 2 ex, 6 tbl
SUBSTANCE: invention relates to medicine, in particular to ophthalmology. Complex treatment including introduction of emoxipin is carried out. For 10 days treatment is carried out in hospital. Additionally lidase is introduced in amount 32-64 units intramuscularly. Nootropyl is introduced intravenously in dose 5-10 ml, cerebrolysin in dose 5-10 ml. Parabulbarly introduced is dexason in dose 0.5 ml. Internally introduced is glyceroascorbate, 1 dessert spoonful, or diacarb - 1 tablet during 4 days with further interval for 3 days, or triampur compositum - 1 tablet 2 times a day. Ten sessions of electrophoresis are carried out, one per day. From negative pole introduced are enzymes from row trypsin, chymotrypsin, papain, lecozim. 3-5 sessions of hirudotherapy on region of temple, every second day, under control of coagulogramme, are carried out. The second stage of treatment is carried out in the outpatient setting during 10 days. Carried out are: intramuscular injection of proserin in dose 0.5-1.0 ml, cortexin in dose 10 mg daily, milgamma - 1.0-2.0 ml every second day. Starting with the 11-th day from beginning of treatment, 10 sessions of electric stimulation and magnetic stimulation of optic nerve are carried out. At the third stage, starting with the 21-st day, during a month carried out are: introduction of phenotropyl - 1 tablet 1 time per day, mexidol - 1 tablet 3 times a day, vinpocetine - 1 tablet 3 times a day. At the fourth stage of treatment, during a month carried out are: introduction of vasobral - 1 tablet 3 times per day, noopept - 1 tablet 2 times per day, hepabene - 1 capsule 3 times per day. Method increases optic functions in said category of patients due to carrying out complex fractional therapy.
EFFECT: method is simple in implementation, is endured by patients well, does not cause complications from central nervous system.
2 ex, 4 tbl
SUBSTANCE: invention belongs to medicine, notably to immunology, otolaryngology and can be used for chronic tonsillitis treatment in patients with immunodeficiency. Method includes sublingual administration of Imudon. Additionally leech therapy in form of medicinal leech application on skin of palatine tonsils projection in mandibular angle area, one leech per side, is performed. Treatment is performed 2 times a week during 3 month, by course 2 times a year, spring and autumn, 2 year in succession.
EFFECT: invention improves treatment effectivity due to effective arrest of chronic tonsillitis exacerbation, recovery of changed immune status, reduction of exacerbations frequency.
1 tbl, 1 ex
SUBSTANCE: invention is related to agriculture, in particular to veterinary medicine or hirudotherapy. Method includes sticking of leeches in turns onto groups of biologically active points: 46, 20 on 1, 7 day; 51, 23 on 3, 9 day and 49, 22 on 5, 11 day.
EFFECT: application of method reduces terms and increases efficiency of dog endometritis treatment.
1 dwg, 1ex
SUBSTANCE: 20-45 ambulatory treatment sessions are held daily, each of which includes several sequential stages: at the first stage muscle-relaxation spinal traction is made by uniform physiological extension of spine in patient's horizontal position on auto-gravitational gym apparatus by means of individual selection of angulation of cervical spine and lumbar spine and elongation with the help of manual graduated stretching mechanism. At the second stage relaxation and vibration longitudinal traction of spinal muscular-ligamentous apparatus is made by means of vibratory massage with graduated extension using "Swing machine". At the third stage acupressure therapy of spinal muscular structure is performed with ebonite rollers along dorsum massage lines. At the fourth stage miofascial massage is alternated with vacuum cupping massage of spinal muscular-ligamentous apparatus. Method enables to influence various pathogeny elements of spinal diseases.
EFFECT: increase of treatment efficiency.
3 cl, 4 dwg, 5 ex
FIELD: medicine; neurology.
SUBSTANCE: occupational therapy is accompanied by application of 2-6 leeches within liver, spleen planes and paraanal area. 4-5 leeches are also applied to umbilicus area.
EFFECT: reduction and normalisation of increased thrombocyte activation; reduction of anxiety and depression.
5 ex, 6 tbl
FIELD: medicine, hirudotherapy.
SUBSTANCE: the present innovation deals with detecting the usefulness and safety of medicinal leeches to be applied for curative purposes. The suggested method for detecting the quality of medicinal leeches deals with weighing a leech, extracting leech's digesta to carry out repeated weighing. One should determine the quality criterion of a leech (C) being equal to the value of the ratio of leech body weight obtained before and after extracting its digesta. At this value being C≥1.327+0.338 Ln (W), where W - leech's body weight, one should establish the terms for leech's starvation being equal to 3 mo, or longer to state upon leech's quality. For detecting the origin of medicinal leech one should form an experimental batch. At homogeneity of quality criterion being in more than 20% of batch s and at the absence of ones at starvation terms being above 6 mo it is possible to state upon the belonging of such leeches to medicinal means named "Medicinal leech". The innovation in question enables to objectively detect leech's starvation terms and excludes the chance for certifying a "wild" leech as "Medicinal means".
EFFECT: higher accuracy and efficiency of detection.
4 cl, 2 dwg, 3 ex, 2 tbl
FIELD: medicine, diagnostics.
SUBSTANCE: it is necessary to detect pulsing points beyond umbilical ring to perform manual impact upon them, additionally, one should apply medicinal leeches onto areas of umbilical ring, pulsing points, anus and for projection of a sick organ. Moreover, the areas mentioned should be affected once, not less during a course that enhances blood and lymph outflow in disease focus.
EFFECT: higher efficiency of therapy.