Benzotriazole uv-absorbers, having absorption spectrum shifted towards long-wave side, and use thereof
SUBSTANCE: described are novel benzotriazole UV-absorbers, having absorption spectrum shifted towards the long-wave side with considerable absorption in the region up to 410-420 nm, having general formulae (a)-(k) (structural formula and values of radicals are given in the description), composition which is stabilised with respect to UV radiation and containing novel UV-absorbers, and use of the novel compounds as UV light stabilisers for organic materials.
EFFECT: obtaining novel benzotriazole UV-absorbers, having absorption spectrum shifted towards the long-wave side.
13 cl, 23 ex, 2 tbl
The text descriptions are given in facsimile form.
1. The compound of formula (a)-(k):
where R1denotes hydrogen, having a linear or branched chain alkyl containing 1 to 24 carbon atoms having a chain unsubstituted or substituted C1-C24alkyl having a linear or branched chain With2-C24alkenyl,5-C12cycloalkyl or3-C6quinil may also include one or more groups-O-, -S-, -NH - or-NR22or combinations thereof;
R22means having a linear or branched chain C1-C18alkyl having a linear or branched chain With2-C18alkenyl,5-C10cycloalkyl, phenyl, naphthyl or7-C15phenylalkyl;
R102denotes hydrogen, -CN, -COR24having a linear or branched chain With1-C24alkyl having a linear or branched chain With2-C18alkenyl,2-C6quinil,5-C12cycloalkyl, phenyl, naphthyl or7-C15phenylalkyl; and
R24indicates OR22, Other22N(R22)2or has the same meaning as R22.
2. The compound of formula (a)-(k) according to claim 1, where
R1denotes hydrogen,having a linear or branched chain alkyl, containing from 1 to 12 carbon atoms, or phenylalkyl containing from 7 to 15 carbon atoms;
R2means having a linear or branched chain alkyl containing from 1 to 12 carbon atoms, or phenylalkyl containing from 7 to 15 carbon atoms, phenyl, or the phenyl or phenylalkyl substituted on the phenyl ring by 1-3 alkilani containing from 1 to 4 carbon atoms.
3. Composition, stabilised against caused by light degradation, which includes:
(a) an organic material subject caused by light decay, which is a natural, semisynthetic or synthetic polymer or coating; and
(b) a compound of the formula (a)-(k) according to claim 1.
4. The composition according to claim 3, which further comprises a sterically hindered amine stabilizer and/or UV absorber selected from the group including SIM-triazine, oxanilide, hydroxybenzophenone, benzoate, α-cyanoacrylate and benzotriazole different from formulas (a)-(k)specified in claim 1.
5. The composition according to claim 3, in which the organic material is a natural, semisynthetic or synthetic polymer.
6. The composition according to claim 5, in which the polymer is a thermoplastic polymer.
7. The composition according to claim 3, in which the organic material is a coating.
8. The composition according to claim 7, in which the coating p is ecstasy a road surface.
9. The composition according to claim 7, where the coating applied to the substrate, which is sensitive to electromagnetic radiation with wavelengths of 380 nm.
10. The composition of claim 8, representing the car floor, including:
a) primer coating, which by electrolytic deposited on a metal substrate;
b) at least one pigmented primary coating that is in direct contact with a primer coating containing a compound of the formula (a)-(k) according to claim 1;
c) a transparent coating that is in direct contact with pigmented primary coating containing a UV-absorber selected from the group including SIM-triazine, oxanilide, hydroxybenzophenone, benzoate, α-cyanoacrylate and benzotriazole different from formulas (a)-(k)specified in claim 1; and
d) optional primer coating contains a compound of the formula (a)-(k) according to claim 1.
11. The composition according to claim 10, in which the primer coating contains a compound of the formula (a)-(k) according to claim 1.
12. The composition according to claim 3, in which the compound of formula (a)-(k) is contained in an amount of 0.1 to 30 wt.% in terms of the mass of organic material.
13. The use of the compounds of formula (a)-(k) according to claim 1 as an absorber of ultraviolet (UV) and visible (VIEW) radiation in the coating.
SUBSTANCE: coating composition has a latex component and a volatile coalescing solvent substituting agent. The agent has the formula: X(AO)nH, where X is a group from C6 to C16, selected from a group of linear chains, branched chains, aromatic rings and combinations thereof, AO is an alkyleneoxy group selected from ethyleneoxy groups, 1,2-propyleneoxy groups, 1,2-butyleneoxy groups and combinations thereof, and n varies from 3 to 14. The coating composition has content of volatile organic compounds less than or equal to 150 g/l. The volatile coalescing solvent substituting agent has little or no contribution into the total level of the volatile organic compounds in the coating composition.
EFFECT: obtaining a coating composition with high continuity and restorability, suitable low-temperature coalescence, resistance to adhesion and operational parameters in freezing and thawing conditions.
25 cl, 11 tbl
SUBSTANCE: electroplating composition contains cyclic guanidine and a polymer which contains a functional group. Said polymer contains a functional group which reacts with said cyclic guanidine and said functional group includes an epoxy group. In the composition, said polymer with cyclic guanidine forms a reaction product. Said cyclic guanidine is 1,5,7-triazabicyclo[4.4.0]dec-5-ene. Use of cyclic guanidine in said composition can cut and/or completely eliminate the need for metallic catalysts such as tin and/or bismuth.
EFFECT: invention enables to form a coating which endows a substrate with corrosion resistance, wear resistance, resistance to damages caused by impact, fire resistance and heat resistance, chemical resistance, resistance to UV light and structural integrity.
67 cl, 33 ex
SUBSTANCE: acrylic lacquer contains an acrylic copolymer dispersion Primal AC-4800ER, a coalescent additive Nexcoat NX-795, a wax additive Aquacer 502, Orotan 681 dispersant, a polyurethane thickener Acrisol RM-2020, a neutraliser - 20% aqueous ammonia solution, an antifoaming agent Nopko NXZ, a preservative Kathon LXE and water.
EFFECT: with the given combination of components, the acrylic lacquer is characterised by good working characteristics and forms a high-lustre transparent coating on wooden articles.
2 tbl, 4 ex
SUBSTANCE: the invention relates to compositions for coating suitable for coating a metal base (preferably a steel one), which will be installed and coated with external cover. The composition contains zinc powder and/or zinc alloy powder and colloid solution of modified silicone dioxide. The colloid solution of modified silicone dioxide contains colloid silicone dioxide particles, modified 6-40% mass of one or several silaned compositions and colloid particles of silicone dioxide. The composition is produced by adding the silaned composition or compositions to colloid solution of the silicone dioxide at the rate below 20 silane molecules per 1 nm2 of the silicon dioxide colloid particle surface per hour.
EFFECT: production of coating composition with considerable durability, good resistance to white rust and good film properties.
13 cl, 4 tbl, 1ex
SUBSTANCE: nanosized silicon with particle size of 5-100 nm is added as a light stabiliser to the recipe of the composition during mixture or synthesis of ingredients thereof. In the surface layer, particles contain silicon dioxide in amount of 0.25-2.5 wt %, having stable spectral absorption of medium-wave UV radiation in the 200-420 nm range. This effect is retained at high temperatures of approximately up to 650 K.
EFFECT: obtaining coatings which do not change colour and operational properties and retain colour- and weather resistance.
2 tbl, 7 ex
SUBSTANCE: coated film has a carrier film selected from a group comprising polyethylene terephthalate, glycol ester (PET-G), nylon, biaxially oriented polypropylene, oriented polypropylene, cast polypropylene, polystyrene, polyethylene, polyvinyl chloride, polylactic acid (PLA), polyhydroxy alkanoate (PHA), polyvinyl chloride and paper; and a coating on at least one surface of the carrier film, containing (a) vermiculite; (b) a polymer capable of forming a film, selected from polyhydroxyl polymer and urethane-containing polymer; (c) a vermiculite dispersant in the polymer, wherein said dispersant bears a negative charge; and (d) a cross-linking agent. The invention also relates to a method of stabilising a suspension containing vermiculite from a shearing action, involving merging a mixture containing one or more cross-linking agents, a polymer capable of forming a film, water and a vermiculite dispersant bearing a negative charge.
EFFECT: improved barrier properties.
24 cl, 3 tbl, 12 ex
SUBSTANCE: composition contains: (a) a film-forming polymer with reactive functional groups; (b) a curing a curing agent with functional groups which react with groups from (a) and (c) an adhesion promoter. The adhesion promoter is obtained from (i) boric acid or boron-containing compounds which are hydrolysed to boric acid, and (ii) an ester with two or more terminal hydroxyl groups. The adhesion promoter is present in an amount which is sufficient to obtain boron content of 0.001-5 wt %. The ester is obtained via condensation of polybasic carboxylic acids and polybasic alcohols, some of which are 1,3-polyol. The ratio of boric acid equivalents or equivalent thereof and hydroxyl is greater than 0.1:1, and the ratio of equivalents of 1,3-polyol and carboxylic acid is greater than 2:1. A multilayer composite is obtained from the heat-curable composition. The composite has a first polymer layer formed on a substrate and a second polymer layer formed on top of the first layer.
EFFECT: invention enables to obtain multilayer composite coatings with improved interlayer adhesion.
31 cl, 6 tbl, 40 ex
SUBSTANCE: costing is obtained from a composition containing a film-forming resin and a plurality of particles dispersed in the resin. The average size of the particles ranges from 0.1 to 50 mcm. The particles have hardness which is sufficient to endow the coating with high resistance to dents and/or scratches compared to a coating in which such particles are not present. Also, the difference between the refraction index of the resin and the refraction coefficient of the particles ranges from 1 to 1.5. The invention also describes a method of preparing a powdered coating which includes particles dispersed in the resin and a coated substrate.
EFFECT: after hardening, the coatings have high resistance to dents and scratches, high resistance to breaking caused by mechanical impacts, as a result of mechanical or chemical wear.
19 cl, 9 ex, 2 tbl
SUBSTANCE: substrate is nonwoven material and the method involves steps for applying a composition in form of an aqueous suspension onto at least one side of the substrate. The composition contains silane, an initiator and an inorganic compound and the initiator is an aqueous acid or base, and the inorganic compound contains at least one metal and/or semimetal. The composition is then dried first at room temperature and then at 200°C after 10 seconds. Further, at least one coating composition is applied onto at least one side of the substrate on which the composition was already applied during the previous step. The coating composition contains silane of general formula (Z1)Si(OR)3, where Z1 denotes R, OR or Gly (Gly=3- glycidyloxypropyl) and R denotes an alkyl having 1-18 carbon atoms and all R can be identical or different, oxide particles selected from oxides of Ti, Si, Zr, Al, Y, Sn, Zn, Ce or mixtures thereof, epoxy resins and an aqueous acid or base as the initiator. The coating composition is dried for 30 minutes at 120°C.
EFFECT: very high flexibility of coated substrates without destroying or cracking the applied coating.
15 cl, 2 ex
SUBSTANCE: protective device comprises assemblage of n>1000 magnetically smoothed flakes that make image. Said flakes rest on substrate in first pattern to form ring or curve. Note here that said flakes are inclined at first angle to substrate while planes that extend flakes surfaces intersect to make image look like 3D object. Note here that bright or dark spot displaces over image on inclining protective device.
EFFECT: optically varying images using magnetically smoother flakes in presence of magnetic fields.
18 cl, 74 dwg
SUBSTANCE: invention relates to novel substituted pyrimidine derivatives, having HIV replication inhibiting properties, or pharmaceutically acceptable salts thereof. In formula (1): R1 denotes hydrogen; R2 and R3 independently denote hydrogen; R7 and R8 denote C1-6alkyl; R4 denotes cyano; R9 denotes C1-6alkyl optionally substituted with cyano, C2-6alkenyl substituted with cyano, C2-6alkynyl optionally substituted with cyano; R5 denotes C1-6alkyl optionally substituted with Ar or Het; C2-6alkenyl optionally substituted with Ar or Het; C2-6alkynyl optionally substituted with Ar or Het; C3-7cycloalkyl; Ar; Het; R6 denotes H, Het; Y denotes -OR11, -NR12R13; R11 denotes hydrogen or C1-6alkyl optionally substituted with hydroxy, C1-6alkoxy or pyridyl; R12 denotes hydrogen or C1-6alkyl; R13 denotes hydrogen or C1-6alkyl; or R12 and R13 together with a nitrogen atom, which is substituted by said two substitutes, form a morpholinyl; imidazolyl; X denotes -NR1-; Het denotes 5- or 6-member completely saturated ring, where one or two ring members are heteroatoms, each independently selected from nitrogen and sulphur, and where the rest of the ring members are carbon atoms; and where any member of the heterocycle with a nitrogen heteroatom can optionally be substituted with C1-6alkyl; where the 5- or 6-member ring can optionally be annelated with a benzene or thiophene ring; each aryl independently denotes phenyl or phenyl substituted with one substitute selected from C1-6alkoxy.
EFFECT: high efficiency of using said compounds.
7 cl, 4 ex, 1 tbl
SUBSTANCE: there are described substituted imidazo[2,1-b]thiazoles of general formula the R1, R1, R3 R4, M1, M2 radical values are presented in the patent claim cl. 1, as well as methods for making them, drug preparations containing these compounds and application of these compounds for making the drug preparations.
EFFECT: higher efficacy.
23 cl, 3 tbl, 25 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to new compounds of formula
wherein: m, n, R0, R1, R2, R3 and R4 have the values presented in clause 1 of the patent claim provided the compound of formula (I) cannot represent N-methyl-1-(phenylsulphonyl)-1H-indole-4-methanamine.
EFFECT: compounds show 5-NT6 receptor antagonist activity that that allows them being used in the pharmaceutical composition.
19 cl, 3 tbl, 192 ex
SUBSTANCE: invention relates to novel agents for controlling plant fungal diseases, specifically 3,7-dithia-1,5-diazabicyclo[3,3,0]octane as an agent against Bipolaris sorokiniana, Aspergillus fumigates, Aspergillus niger, synthesis of which takes place in a single step using readily available reactants in contrast to multi-step synthesis of existing agents used for controlling fungal diseases of plants and materials.
EFFECT: obtaining novel agents for controlling plant fungal diseases.
SUBSTANCE: invention relates to a novel heteroaryl-substituted derivative of benzothiazole - 2-[6-(methylamino)pyridin-3-yl]-1,3-benzothiazol-6-ol where one or more atoms may be a detectable isotope, in form of a free base or pharmaceutically acceptable salt thereof, capable of binding with amyloid deposits, to pharmaceutical compositions based on the radioactive-labelled disclosed compound, to use of the detectable isotope-labelled disclosed compound for determining amyloid deposits, as well as use of the disclosed compound in producing a medicinal agent for preventing and/or treating Alzheimer's disease and familial Alzheimer's disease. The present invention also relates to a novel intermediate compound for producing the disclosed heteroaryl-substituted benzothiazole derivative
EFFECT: high efficiency of using the compounds during treatment.
15 cl, 1 tbl, 15 dwg, 82 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to (R)-N-(3-amino-propyl)-N-[1-(5-benzyl-3-methyl-4-oxo-4,5-dihydro-isothiazolo[5,4-d]pyrimidin-6-yl)-2-methyl-propyl]-4-methyl-benzamide substantially free from (S)-N-(3-amino-propyl)-N[1-(5-benzyl-3-methyl-4-oxo-4,5-dihydro-isothiazolo[5,4-d]pyrimidin-6-yl)-2-methypropyl]-4-methyl-benzamide, or its pharmaceutically acceptable salt which shows the properties of Eg5 inhibitor.
EFFECT: invention also refers to a pharmaceutical composition containing said compound and its pharmaceutically acceptable salt.
4 cl, 27 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to compounds of general formula
where R1 represents CH3; R2 represents halogeno or CN; R3 represents H or CH3; R4 represents H or CH3; n represents 0, 1 or 2; and to their pharmaceutically acceptable salts. Also, the invention refers to a pharmaceutical composition and to application of the compounds of formula (I) in preparing a drug exhibiting antagonist activity in relation to CX3CR1 receptor.
EFFECT: provided the compounds of formula (I) as CX3CR1 receptor antagonists.
20 cl, 1 tbl, 3 dwg, 10 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to compounds of general formula (I) where the bond b represents a double bond; X represents -S-; each Z1 and Z3 independently represents a direct bond, -N(R5) - or - (CH2)q; Z2 represent -C(O)- or -C(S)-; m represents an integer equal to 1; n represents an integer equal to 1; each of q independently represents an integer varying within 1 to 4; R0 represents hydrogen, halogen, hydroxy, unsubstituted C1-C3alkyl or unsubstituted C1-C3alkoxy; R1 is independently selected from a group consisting of halogen, optionally substituted C1-C3alkyl, -R6OR7, -R6N(R7)2, -R6C(O)R7, -R6C(O)OR7, -R6C(O)N(R7)R9N(R7)2, -R6OC(O)R8, -R6C(O)N(R7)2 or -R6OR9N(R7)2; R2 represents hydrogen; R4 is selected from a group consisting of morpholine, isoxazolyl, thiazolyl, oxazolyl, benzisoxazolyl, benzothiazolyl, dioxynyl, dioxolyl, and optionally substituted phenyl. Also, the invention refers to pharmaceutically acceptable salts of the compounds of formula (I) and to a pharmaceutical composition exhibiting antiproliferative activity and containing the compounds of formula (I).
EFFECT: preparing the compounds of formula (I) exhibiting antiproliferative activity.
21 cl, 11 dwg, 5 tbl, 19 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to new compounds or their pharmaceutically acceptable salts where the compound has formula (I). The compounds have the properties of hepatitis C virus (HCV) replication inhibition and can be used for treating HCV-infection. In formula (I) B represents heterocyclyl selected from thieno, thiazolo, pyrazolo, pyrido and pyrimidogroup with B being optionally substituted by one or more R18, A represents phenyl which is optionally substituted by one or more R18; each W1 and W2 are independently selected from N or C(R33); Z represents -NH-; each R10 and R33 containing of hydrogen; X is selected from a group consisting of -Ls-O-, -Ls-S-; R22 means hydrogen or phenyl optionally substituted by one or more R26 ; Y is selected from a group consisting of -Ls-O-, -Ls-S-; -Ls-C(O)- and -Ls-NH(SO)2-; R50 represents -L1-A1, where L1 represents a bond, and A1 is selected from a group consisting of carbocyclyl where carbocyclyl represents phenyl or C3-C6carbocyclyl, banzimidazolyl and C1-C6alkyl optionally substituted by phenyl where A1 is optionally substituted by one or more R30 ; the substitute values are specified in the patent claim.
EFFECT: preparing the compounds exhibiting the properties of hepatitis C virus replication inhibition.
17 cl, 8 dwg, 255 ex
SUBSTANCE: invention relates to compounds of general formula where R1 denotes CH3; R2 denotes halogen or CN; R3 denotes H or CH3; R4 denotes H or CH3; n equals 1; and pharmaceutically acceptable salts thereof. The invention also relates to a pharmaceutical composition and use of compounds of formula (I) in preparing a medicinal agent, having CX3CR1 receptor antagonist activity.
EFFECT: compounds can be used as CX3CR1 receptor antagonists.
13 cl, 1 tbl, 10 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: described is a new polycyclic compound with general formula (I-1) and (1-3) or a pharmaceutically acceptable salt thereof where X1- -CR1 =CR2 - where R1 and R2 independently stand for hydrogen or C1-6 alkyl while Het stands for a radical of the following formulae: that may be substituted 1-3 times additionally described is a pharmaceutical composition containing such compound and intended for prevention or treatment of diseases caused by β-amyloid.
EFFECT: production of a pharmaceutical composition prevention or treatment of diseases caused by β-amyloid.
7 cl, 392 ex, 12 tbl