Gel composition and using it

FIELD: medicine.

SUBSTANCE: present invention refers to medicine, more specifically to a gel composition for a medical material or a hygienic material which contains a liquid rubber ingredient having a functional group able to create cross linkages, in a molecule, and 90 weight parts or more and 1250 weight parts or less of an organic liquid ingredient in relation to 100 weight parts of the rubber ingredient with the gel composition being cross-linked.

EFFECT: composition for the medical material or the hygienic material contains a great amount of the organic liquid ingredient, has sufficient elasticity and can hold its shape.

7 cl, 4 tbl

 

The technical FIELD

The present invention relates to a gel composition, the molten product, sheet material, plaster and manufacture of plaster for medical and hygienic materials.

BACKGROUND of the INVENTION

Usually sheet materials of various gel compositions, such as hydrogel composition, the acrylic composition, etc. are used as medical or hygienic materials. Because these gel compositions have adhesive properties and elasticity, they can stick to skin and to follow the deformation of the skin.

However, the water-containing hydrogel composition of these adhesive compositions are susceptible to drying, tend to lose water and become hard, and have a low stability. In addition, this cured composition is unsatisfactory in relation to the properties of adhesion to the skin and the ability to follow its deformation.

On the other hand, as a gel material, free from water, patent JP-A-3-220120 (reference patent 1) discloses acrylic gel composition that hold organic liquid component through the cross-linkage with acrylic adhesive.

However, since the casting of such gel compositions in sheet material having a certain thickness, is difficult, is capable of the TB compositions retain or absorb inside chemical substance, such as a medicine and the like, an organic liquid component, etc. is still limiting, and the songs can't hold them in large quantities. Moreover, it is difficult to mold such a gel composition in a molten product with a large thickness. When a thin molten product adheres to the skin, you may wish to further improve its ability to absorb external impact and protect the skin.

As other gel materials can be applied adhesive layer, obtained by cross-linking of synthetic rubber polymers. As such an adhesive layer suggested the following.

JP-A-3-127727 (reference patent 2) discloses an adhesive mainly consisting of neurilemoma connection and having a glass transition temperature -71°C or below, and an adhesive layer containing a reinforcing filler and a pharmaceutical agent, i.e. a gel composition. However, this reference does not disclose that the composition contains 90 weight parts or more organic liquid component relative to 100 weight parts of rubber component. Moreover, this reference discloses that adding too much organic liquid component (described in the link as a material that lowers the temperature Tg) gives too soft gel composition. This means too much to icesto organic liquid component in the gel composition leads to unsatisfactory property of the form is saved. In fact, in the examples of this document describes that the adhesive was left behind from the surface to 3 mm or less from one end, when they were put on the human body.

JP-A-10-151185 (reference to patent 3) discloses a gel composition comprising 30 to 100 parts by weight of a rubber component having a functional group, 0-70 parts by weight of other rubbers and 20-80 parts by weight of an organic liquid component compatible with the rubber component, relative to 100 weight parts of rubber component, where the gel composition is cross-linked. However, this reference does not disclose that the gel composition contains 90 weight parts or more organic liquid component relative to 100 weight parts of rubber component. However, this reference discloses that adding too much organic liquid component gives too soft gel composition. This means that too much of the organic liquid component in the gel composition leads to poor property retention form.

Therefore, there is a need to provide a composition for a medical material or a hygiene material, which contains a large amount of organic liquid component has a satisfactory elasticity and capable of storing four is at.

Reference patent 1: JP-A-3-220120

Reference patent 2: JP-A-3-127727

Link to patent 3: JP-A-10-151185

Description of the invention

Issues that should resolve the invention

In view of the above facts, the present invention relates to compositions for medical material and hygienic material that contains a large amount of liquid organic component has a sufficient elasticity and is able to save the form.

Part of the solution

The inventors have conducted intensive studies to solve the above problems, in which it was found that the gel composition containing the specific liquid rubber component and an organic liquid component in a certain ratio, can solve the above problem. The inventors have unexpectedly discovered that such a gel composition can be cast with a certain thickness, and a gel composition having such a thickness can provide a new effect, such that it can contain a large number of chemical substances, such as medicine and the like, an organic liquid component and the like, per unit area, which led to completion of the present invention. Namely, the present invention relates to:

(1) a gel composition for medical or hygienic mA is erila, which contains a liquid rubber component having a functional group capable of forming cross-links in the molecule, and 90 weight parts or more and 1250 weight parts or lower organic liquid component, relative to 100 weight parts of rubber component, and this gel composition is cross-linked;

(2) the composition of (1), where the liquid rubber component contains in the molecule of 3 or more functional groups capable of reaction cross-linkage;

(3) the composition of (1) or (2), where the organic liquid component is contained in a proportion of 150 weight parts or more and 1000 weight parts or less relative to 100 parts by weight of the liquid rubber component;

(4) the composition according to any of (1) to (3), where the composition is cross-linked using a cross-linking agent, and the ratio of total (A) functional groups of the crosslinking agent in the composition to the total number (In) of functional groups of the liquid rubber composition ((a/b)×100)[%] is not less than 50[%];

(5) the composition according to any of (1) to (4), where the liquid rubber component is a liquid isoprene rubber;

(6) the patch with sheet material containing the composition according to any one of (1)to(5) on at least one surface of the substrate; and

(7) the drug in the form of a patch containing plaster is from (6), containing drug to the sheet material.

The implementation of the invention

Since the gel composition of the present invention has sufficient elasticity and can save the form, it can be to get castings of any shape, for example a sheet of the drug.

In addition, since the gel composition of the present invention may contain a large amount of organic liquid component, it may contain a large number of chemical substances, such as medicine and the like, dissolved or dispersed therein. As a result, a chemical substance such as a drug, etc. thus contained in the liquid component can be successfully applied in a mammal by transdermal injection, etc.

Moreover, since the gel composition of the present invention has an appropriate elasticity, when it is cast into a predetermined shape and placed on the skin in the form of a cast product, it can easily follow the deformation of the skin and is able to fit snugly to the skin. In addition, since the composition can be poured into a cast product having a certain level of thickness, when the adhesion of the molded product to the skin can disperse or reduce damage to the skin stress to protect the skin. Therefore, the gel composition of this image is to be placed, with such quality, especially suitable for medical material or a hygiene material.

As mentioned above, since the gel composition of the present invention can be poured into a cast product having a certain thickness, the gel composition of the present invention with such a thickness can provide a new effect, because it may contain a large number of chemical substances, organic liquid component, etc. per unit area.

In addition, since the gel composition of the present invention does not require the use of acrylic adhesive, when the gel composition contains a specific type of chemical substance such as a drug and the like, the possibility of changing the substance as a result of interaction between matter and acrylic adhesive is low, and the degree of freedom of selection of substances is high, and this substance can be stably used.

The best option of carrying out the invention

Gel composition for medical material or a hygiene material of the present invention contains a liquid rubber component having a functional group capable of crosslinking in the molecule, and an organic liquid component. The organic liquid component is contained in a ratio of 90 weight parts or higher is 1250 weight parts or lower relative to 100 weight parts of rubber component. The gel composition is cross-linked.

In the present invention, the liquid rubber component is involved in the formation of a mesh structure after cross-linking of the gel composition and gives a gel composition elasticity and ability to retain the shape.

The choice of the liquid rubber component is not specifically limited, and its examples include liquid isoprene rubber, liquid polybutadiene rubbers, liquid isobutilene rubbers, etc. that can be used by themselves or in combination with two or more types of rubbers. Liquid rubber component is a liquid, even if it has a high molecular weight, allowing the gel composition may contain a large amount of organic liquid component, and the gel composition is easily attached to the elasticity. Therefore, it is preferable liquid isoprene rubber. "Liquid" in this description means having fluidity at 25°C.

Although srednevekovoi molecular weight liquid rubber component is not particularly limited, until the rubber component is a liquid, the preferred molecular weight is 1000-60000, more preferably capabilities from 10,000 to 40,000, more preferably 20000 to 30,000. When the average molecular weight less than 1000, the gel composition cannot easily contain a large number of organizes the th liquid component, that may reduce the elasticity of the gel composition. Although the mechanism for this remains unknown, it is believed that the cells in the network structure becomes small, reducing the molecular weight between cross-linkage points of the liquid rubber component.

On the other hand, when the molecular weight exceeds 60000, liquid rubber component may not be liquid, and, in addition, it is not easy to maintain the homogeneity of the gel composition. In other words, it can be difficult to maintain compatibility of the liquid rubber component with other components of the gel composition.

Used in the present description srednevekovoi molecular weight means a value measured by gel permeation chromatography under the following conditions:

(analysis options)

the chromatograph for gel permeation chromatography: HLC8120 (manufactured by Tosoh Corporation)

column: TSK gel GMH-H(S) (manufactured by Tosoh Corporation)

standard: polystyrene

eluent: tetrahydrofuran

flow rate: 0.5 ml/min

measure temperature: 40°C

means of detection: differential Refractometer

Whether or not the gel composition of the present invention cross-linked, determined as described below. A sample of the gel composition is placed in toluene at room temperature for 6 days and visually confirm presets is of the insoluble fraction. When insoluble fraction is present, the gel composition is cross-linked.

Despite the fact that the number of functional groups capable of forming cross-links are not specifically limited, as the liquid rubber component has in the molecule not less than three functional groups capable of forming cross-links, it effectively forms a mesh structure, resulting in the effect of the present invention expressed in a sufficient degree. From this point of view, the number of functional groups in the molecule of the liquid rubber component is preferably not less than 5, more preferably not less than 8, most preferably not less than 10. On the other hand, when the number of functional groups is too large, it increases the required amount of crosslinking agent, it is preferable that the number of functional groups in the molecule does not exceed 20.

In the present invention, since the liquid rubber component is not less than three functional groups capable of forming cross-links in the molecule, can form a three dimensional structure without the necessity of introducing agents of education of the side chains, etc. in the main chain of the liquid rubber component, the gel composition may contain a large amount of organic liquid is wow component.

On the other hand, it is preferable that the number of functional groups in the molecule of the liquid rubber component was not more than 15, more preferably not more than 12. As too a large number of functional groups gives a lot of residual active groups and can affect the components in the gel composition, such as a medicine and the like, and can also reduce the elasticity of the gel composition, thus leading to impaired ability to follow the deformation of the skin.

The number of functional groups capable of reaction of formation of cross-links in the molecule of the liquid rubber component, determined as described below. Determine the sample the total number of functional groups capable of forming cross-links in the liquid rubber component, then divide this number by srednesemennyh molecular weight liquid rubber component, receiving the number of functional groups capable of reaction of formation of cross-links per 1 molecule of the liquid rubber component. When the functional group is a carboxyl group, the number of carboxyl groups in the sample is determined by measuring the number of acid groups, using a conventional potassium hydroxide. Srednesemennyh molecular weight liquid rubber component in the present description means the value obtained is ri the same conditions, as for the above srednevekovogo molecular weight.

The functional group is not specifically limited and, for example, you can use the amino group, carboxyl group, hydroxyl group, chlorosulfonic group, hard-ester group, epoxypropyl, isocyanate group, methylol group, a sulfonic acid group, mercaptopropyl, etc. can be used alone or in combination with two or more types of functional groups. From the point of view of education cross-linkage with epoxysilane, mentioned below using a crosslinking agent, preferred are carboxyl and hydroxyl groups.

In the present invention, the gel composition is cross-linked. Although the impact, leading to the formation of cross-links, are not specifically limited, for example, the cross-linkage can be obtained by physical impact upon irradiation with UV light, electron beam, etc. or by chemical crosslinking using various cross-linking agents.

To prevent negative impact on the component in the gel composition, such as a drug, gel composition preferably stitched by adding a crosslinking agent to a gel composition. Examples of crosslinking agents include isocyanate compounds, such as the amine compound, epoxysilane, trifunctionally isocyanate and the like, organic peroxide, organic salt of a metal alcoholate, metal chelate compound of the metal, multifunction connection (multifunctional external crosslinking agent, the monomers for the formation of internal cross-links, such as diacrylate, dimethacrylate and the like), etc. that can be used individually or in combination of two or more kinds of crosslinking agents. As a cross-linking agent is preferable epoxysilane. As a result of the reaction of epoxypropyl with a carboxyl group in the liquid rubber component is formed hydroxyl group, it can react with another carboxyl group, which is advantageous for the formation of a reticular structure.

Although the proportion of mixed cross-linking agent is not specifically limited, while in the gel composition can be formed sufficiently cross-linked structure, the ratio of the total number of (A) functional groups of the crosslinking agent in the composition to the total number (In) of functional groups of the liquid rubber composition ((A/B)×100)[%] is preferably not less than 50[%], more preferably not less than 80%, most preferably not less than 300%. Although the upper limit of the ratio is not specifically limited, to prevent negative pliniana component of the gel composition, this ratio is preferably not more than 500%.

In the present invention the organic liquid component is connected with a mesh formed of the above-mentioned liquid rubber component, and increases the elasticity of the gel composition. When a chemical substance such as a drug and the like, contained in the gel composition, the organic liquid component is valid, dissolving or dispersive substance in itself, resulting in a gel composition comprising an organic liquid. The organic liquid component is not specifically limited, while it is compatible with the liquid rubber component in the gel composition. Examples include fats and oils, such as olive oil, castor oil, lanolin and the like, hydrocarbons such as squalane and liquid paraffin, fatty acid esters such as alkyl esters of fatty acids and the like, higher fatty acids such as oleic acid and Caprylic acid, pyrrolidone, such as N-organic N-dodecylmercaptan, sulfoxidov, such as decelerated, etc. that can be used individually or in combination of two or more kinds of them.

As shown in the following drug is a patch, if the gel composition comprises a drug, to enhance the absorption of drugs through the skin is preferred complex e is Il fatty acids. Its examples include alkyl diesters of fatty acids, such as dioctylphthalate, diisopropylamide, diethylsilane and the like, alkyl monoether fatty acids, etc. For enhancing the absorption of drugs through the skin preferred alkyl monoether fatty acids.

When alkyl monoether fatty acid contains a fatty acid having excessively large or small number of carbon atoms, the above-mentioned compatibility with synthetic rubber, etc. may be broken, or the acid can evaporate on heating stage in the manufacture of the drug. In addition, when monetary contain fatty acids having a double bond in the molecule, can occur oxidative decomposition and the like, causing stability problems during storage.

When using alkyl monoamino fatty acids, it is preferable to use alkyl ester of fatty acids consisting of saturated or unsaturated higher fatty acids, preferably having the number of carbon atoms from 12 to 16, more preferably 12 to 14, and saturated or unsaturated lower monohydroxy alcohol, preferably having the number of carbon atoms from 1 to 4. Examples of alkyl monoamino higher fatty acids preferably include lauric acid (C12), myristic acid (C14) and palmitic acid (C16), in which W is STI myristic acid and palmitic acid. Examples of the lower monohydroxy alcohols include methyl alcohol, ethyl alcohol, propyl alcohol and butyl alcohol. They are not limited remotemachine alcohols and may be branched alcohols. Especially preferred isopropyl alcohol. Accordingly, the most preferred alkyl esters of fatty acids are isopropylmyristate and isopropyl.

The ratio of these organic liquid components for mixing is 1250 weight parts or less, preferably 1000 weight parts or less, more preferably 950 weight parts or less, more preferably 900 weight parts or less, more preferably 850 weight parts or less, more preferably 800 weight parts or less, more preferably 750 weight parts or less, more preferably 700 weight parts or less, most preferably 650 weight parts or lower relative to 100 parts by weight of the liquid rubber component. When the ratio exceeds 1250 parts by weight of the gel may not be formed and the composition cannot be cast in the specified form.

On the other hand, the ratio of organic liquid component for mixing 90 weight parts or higher, preferably 150 weight parts or higher, more preferably 200 weight parts or more, more preferably 250 in the lowest parts or higher, most preferably 300 weight parts or higher relative to 100 parts by weight of the liquid rubber component. When the ratio is less than 90 weight parts, the gel may become too hard and can disrupt the property of adhesion to the skin and the ability to follow the deformation of the skin. In addition, can disrupt the ability to diffusive migration of other components inside the gel composition and the absorption of the gel composition.

The gel composition of the present invention contains an organic liquid component in a quantity equal to or greater than the amount of the liquid rubber component. This may be the reason for the appearance of the structure in which the organic liquid component is simply present in the network structure of the liquid rubber component, which is formed by cross-linking of the gel composition. Rather, however, to assume that rather liquid rubber component is present in the organic liquid component in the structure. As a result, I believe that the gel composition of the present invention, is molded in a predetermined shape and attached to the skin in the form of a cast product, shows the optimal elasticity that allows you to easily adhere to the skin and is free to follow its deformation.

The gel composition may contain other optional components, while not inhibited the playing technique of the present invention. For example, the composition may contain surfactants such as glycerin fatty acid esters, sorbitane esters of fatty acids and the like, high-temperature organic solvents, such as dimethylsulfoxide, N-organic, etc., amplifiers absorption, such as pyrrolidonecarboxylic and the like, antioxidants such as ascorbic acid and other agents in slowing the aging process, fillers, dyes, plasticizers, etc.

The gel composition of the present invention can be poured into a cast product having a predetermined shape. Examples of shape cast products include sheet preparation, medication in the form of briquettes, etc. For use in medical material or a hygiene material is preferred sheet preparation, i.e. sheet material.

Such a cast product can be given the shape of the sheet product (sheet material)having a certain thickness, for example at least 0.5 mm, at least 1 mm, at least 2 mm or less than 3 mm and not more than 10 mm, Such sheet material has a greater thickness than the thickness of the adhesive layer normal of the patch, and its advantage is that it can contain a larger amount of liquid organic component, chemical substances, such as medicine, etc.

For use as a medical the of material, for example, we can mention the patch, in which the molded product of the present invention molded on at least one surface of the substrate. This patch is used to protect the skin surface and the like, Although the substrate is not specifically limited, it is preferable for the substrate, which is practically impermeable to components of cast products; in other words, the substrate, through which the components of the molded product are not lost through the back side, thereby lowering their content. If desirable, the force of adhesion of the molded products can independently increase the adhesive. If desired, to protect the cast product to use its surface can be covered with a protective film.

Moreover, the drug is in the form of a patch can be obtained by saturation of the cast product in the above patch drug. Drug in the present description is not specifically limited, but preferred is a drug that can be administered to a mammal, such as man and so on, through the skin, i.e. the drug absorbed through the skin. Examples of drugs include, in particular, General anesthetics, hypnotic sedatives, antiepileptic drugs, antipyretic, analgesic and anti-inflammatory medication is nye drugs medicines for vertigo, psihonevroticheskih drugs, local anesthetics, skeletal muscle relaxants, drugs acting on the autonomic nervous system, anticonvulsants, ANTIPARKINSONISM drugs, antihistamines, cardiac stimulants, drugs against arrhythmia, diuretics, drugs, lowering the pressure, vasoconstrictor drugs, coronary vasodilator drugs, peripheral vasodilating drugs, medications atherosclerosis, drugs acting on the circulatory system, drugs, enter in the lungs, antitussive expectorants drugs, hormone drugs, external drugs for pyogenic infection, analgesic, antipruritic, hemostatic, anti-inflammatory medicines medicines from parasitic skin diseases, hemostatic drugs, drugs for treatment of gout, anti-diabetic drugs, drugs for treatment of malignant tumors, antibiotics, chemotherapy drugs, drugs, drugs for treatment of nicotine addiction, etc.

The proportion of drug in the gel is the first composition is not specifically limited as long while it provides the effect of absorption of the drug through the skin and does not affect the properties of the gel composition. It is preferably from 0.1 to 60 wt.%, more preferably from 0.5 to 40 wt.% from the gel composition. When the content of the drug is lower than 0.1 wt.%, the effect may be insufficient, while when it exceeds 60 wt.%, may develop skin irritation, and this proportion may also be economically disadvantageous.

The molded product of the present invention can particularly be used as a matrix in the matrix type patches, as the reservoir in the patch reservoir type.

In a hygienic material cast product having a defined shape, such as sheet product (sheet material), can be used as a substitute for cheesecloth in the plaster, as the substrate gel patch as non-woven Deputy for material for covering wounds, etc.

The gel composition of the present invention can be obtained, for example, as follows: mix the liquid rubber component and an organic liquid component, if necessary, in the presence of a solvent, to add a crosslinking agent and the mixture is then poured into the form with the specified form. It is heated to the appropriate temperature to remove the solvent, and is cross-stitching liquid what about the rubber, when necessary, keeping.

Examples

(Examples and comparative examples)

Carboxypropanoyl liquid polyisoprene (srednevekovoi molecular weight 25000) as a liquid rubber component having 10 functional groups capable of forming cross-links in the molecule, and isopropylmyristate as an organic liquid component were mixed in ratios shown in table 1, was mixed into the compound (srednesemennyh molecular weight of 366)containing tetrafunctional apachegroup to meet "the ratio of the functional groups listed in table 1. The mixture was which and mixed, obtaining a composition for the formation of a gel composition. It was poured in a container of predetermined shape in a predetermined amount, heated for 3 hours at 120°C for cross-linkage and kept at 80°C for 72 hours, obtaining castings of the gel compositions in accordance with examples and comparative examples. "The ratio of functional groups" means the ratio of the total number of (A) functional groups in the crosslinking agent in the composition to the total number (In) of functional groups of the liquid rubber composition ((A/B)×100)[%].

Table 1
Proportions when mixing
Liquid rubber component (weight parts)The organic liquid component (weight parts)The ratio of functional groups (%)
Comparative example 110080100
Example 1100100100
Example 2100200100
Example 3100400100
Example 4100500100
Example 5100600100
Example 6100700100
Example 7100800100
Example 81000100
Comparative example 21001500100
Example 9100200200
Example 10100400200
Example 11100500200
Example 12100600200
Example 13100700200
Example 14100800200
Example 15100100400
Example 16100200400
Example 17100 400400
Example 18100600400
Example 191001000400
Example 201001000800
Example 211006001000
Example 2210050050
Example 2310060050
Example 2410070050
Example 2510080050

(Experimental example)

(1) the gel Formation

The above-mentioned composition for forming the gel composition was poured in a glass vessel (inner diameter 36 mm, depth 60 mm) to a height of about 10 mm, were made as described in the above, and kept getting cast products of the examples and comparative examples. The formation of the gel cross-linking and its ability to retain its shape was evaluated visually according to the following criteria:

: Gel was formed to maintain the form and shape was preserved even when the tilt of the glass vessel at 90° or more.

: Gel was formed when the organic liquid component is performed on the surface.

: The gel is not formed, and the specified form is not supported (liquid state). The results of the evaluation of the formation of the gel shown in table 2.

Table 2
The results of the evaluation of the formation of a gel
The ratio of the blending (weight parts) organic liquid component relative to 100 parts by weight of the liquid rubber component
The ratio of functional groups (%)801002004005006007008001000/td> 1500
50Example 22Example 23Example 24Example 25
100Comparative example 1Example 1Example 2Example 3Example 4Example 5Example 6Example 7Example 8Comparative example 2
200Example 9 Example 10Example 11Example 12Example 13Example 14
400Example 15Example 16Example 17Example 18Example 19
800Example 20
1000Example 21

(2) the Elasticity

The above-mentioned composition for forming the gel composition was poured in a glass Petri dish (internal diameter of 90 mm, depth 18 mm) to a height of 10 mm were made and kept, as described above. Composition of the stencil cut out a circle with a diameter of 30 mm, receiving the cylindrical sample.

The test load was measured by a rheometer, when a steel ball (diameter 10 mm) was pressed into the centre of the sample of 3 mm at a speed of 20 mm/min Lower test load means that the sample is elastic. A similar measurement was carried out on the human skin and the results are shown in the following table 3, the Results of measuring the load test on human skin". Thus identified the following criteria and the estimated elasticity of the gel composition.

Table 3
The measurement results of the load test on human skin
PlotTest load (N)
Hand A thick section0,26
Thin section6,40
ArmA thick section0,44
Thin section8,58
Thin section9,76
ForearmA thick section0,66
Thin section2,46
Thin section9,38

(Criteria)

: Test load is 0.2 or more and less than 8. That is, the elasticity is equivalent to the elasticity of most sections of human skin and the ability to follow the deformation of the skin is very high.

: Test load is 8 or higher and less than 10. That is, the elasticity is equivalent to some rigid parts of the human skin and the ability to follow the deformation of the skin is high.

: Test load is 10 or higher and less than 14. That is, the sample is relatively inflexible compared to skin che is oweka, and the ability to follow the deformation of the skin is sufficiently low. However, the flexibility of the sample is similar to the flexibility of human skin and the sample is assessed as satisfactory.

: Test load is 14 or below. That is, the sample is inflexible in comparison with human skin and the ability to follow the deformation of the skin is low.

The results of the elasticity estimates presented in table 4.

Table 4
The results of estimation of elasticity
The ratio of the blending (weight parts) organic liquid component relative to 100 parts by weight of the liquid rubber component
The ratio of functional groups(%)8010020040050060070080010001500
50 0,037
10014,2112,115,981,500,302
200 7,78B0,526
400RS 9.696,001,700,035
800being 0.036

As can be seen from table 2, the gel formed in any example, where the amount of organic liquid component was 80-1000 weight parts relative to 100 weight parts of liquid rubber component, and the form has been successfully saved. Like the examples 25 and 8, where the amount of liquid organic component was 800 and 1000 weight parts relative to 100 weight parts of liquid rubber component, the organic liquid component is allocated on the surface of the gel in some of them, depending on the ratio of the functional groups. Comparative example 2 containing 1500 parts by weight of EO is ancescao liquid component, do not form a gel. This means that it is preferable to increase the mixing ratio of crosslinking agent to increase the ratio of functional groups, depending on the mixing ratio of the organic liquid component.

As is clear from table 4, the examples in which the amount of organic liquid component was 100 to 1000 weight parts relative to 100 weight parts of liquid rubber component, showed elasticity, similar to the elasticity of human skin, and the ability to follow the deformation of the skin was high. Especially the samples in which the amount of organic liquid component comprised between 200 and 600 weight parts, demonstrated the elasticity is equal to the elasticity of the human skin, and they were assessed as having a particularly high ability to follow the deformation of the skin.

This application is based on patent application No. 2007-158669 filed in Japan, the contents of which are fully incorporated herein by this reference.

1. Gel composition for medical material or a hygiene material, which contains the liquid rubber component is at least one kind selected from a liquid isoprene rubber, liquid polybutadiene rubbers and liquid isobutilene rubber, and having a functional group capable of forming cross-links in the molecule, and 90 is ESC or higher and 1250 parts or below the organic liquid component at least one kind selected from fats and oils, hydrocarbons, fatty acid esters, higher fatty acids, pyrrolidone and sulfoxidov, relative to 100 parts by weight of the rubber component, and the gel composition is cross-linked.

2. The composition according to claim 1, in which the liquid rubber component contains in the molecule of 3 or more functional groups capable of forming cross-links.

3. The composition according to claim 1, in which the organic liquid component is contained in a ratio of 150 parts or more and 1000 parts or lower relative to 100 parts of liquid rubber component.

4. The composition according to claim 1, in which the composition is cross-linked by a crosslinking agent, and the ratio of the total number of (A) functional groups of the crosslinking agent in the composition to the total number (In) of functional groups of the liquid rubber composition ((a/b)·100)[%] is less than 50[%].

5. The composition according to claim 1, in which the liquid rubber component is a liquid isoprene rubber.

6. Plaster containing sheet material, comprising the composition according to claim 1 on at least one surface of the substrate.

7. The drug is in the form of a plaster containing patch according to claim 6, containing the drug in a sheet material.



 

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11 cl, 1 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: present invention refers to medicine, more specifically to a multi-component superabsorbent fibre which includes a first superabsorbent material and a second superabsorbent material. At least on a portion of a lengthwise (L) direction of the superabsorbent fibre, the first superabsorbent material and the second superabsorbent material are parallel in a crosswise (C) direction of the superabsorbent fibre. The first and second superabsorbent materials are selected so that in the given point during swelling, the swelling capacity (SC) of the first superabsorbent material exceeds the swelling capacity of the second superabsorbent material so that the superabsorbent fibre (10) curls in contact with fluid. Also, the invention refers to a method of reduced gel blockage in the superabsorbent fibre.

EFFECT: in contact with fluid, the fibres provided an open structure which reduces gel blockage.

10 cl, 6 dwg, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to absorbing product, such as diaper, panties-diapers, hygienic napkin or device against incontinence, containing upper liquid-permeable layer, lower layer and absorbing internal layer, placed between said upper liquid-permeable layer and said lower layer, said absorbing internal layer containing acid cellulose fibres, which have pH value at the level 5.5 or lower, and zinc organic salt, in particular, zinc ricinoleate.

EFFECT: combination of zinc organic salt and acid shredded cellulose produces synergetic effect on ammonia suppression.

22 cl, 1 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: present invention refers to medicine, more specifically to an absorbent product, such as diapers, panty diapers, sanitary towels or incontinence aids, comprising a moisture-resistant front layer, a moisture-resistant back layer and an absorbent inner layer between said moisture-resistant front layer and said moisture-resistant back layer wherein said absorbent inner layer contains the superabsorbent material characterised by the fact that said superabsorbent material represents an acid superabsorbent material of pH 5.5 or less; the absorbent inner layer in addition contains organic zinc salt, particularly zinc ricinoleate. The combination of organic zinc salt and the acid superabsorbent material shows synergetic effect in suppressing formation of odour nuisance base compounds, such as ammonia.

EFFECT: higher effectiveness of odour control.

12 cl, 2 tbl, 9 ex

FIELD: medicine.

SUBSTANCE: there are described adhesive compositions and application of these compositions, e.g. their application as blister pads and wound dressings.

EFFECT: preparation of the adhesive compositions which has improved initial viscosity, long-term adhesion, water entrapment and transparency characteristics and can be prepared by melt extrusion.

30 cl, 7 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: there is described absorbing product which comprises a stretchable carrier layer and an absorbing core formed directly on the carrier layer, and adhesively attached thereto. The absorbing core contains about 40-99 wt % of superabsorbing particles and about 1-60 wt % of adhesive fibres. The absorbing core does not prevent extension of the carrier layer or the absorbing product.

EFFECT: mentioned absorbing product can be a personal hygiene absorbing product or a medical absorbing product, and is stretchable or elastic.

18 cl, 8 dwg, 3 tbl

FIELD: medicine.

SUBSTANCE: there is described adsorbing product including a coating layer, a barrier layer and an adsorbing system between said coating layer and barrier layer.

EFFECT: adsorbing product is draped and exhibit adsorption properties necessary for a sanitary towel.

10 cl, 2 tbl, 7 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine. What is described is a bandage for pain region processing. The bandage provides cooling and delivery of therapeutic formulations to this region. The bandage comprises a bearing carrier, an interpenetrating network of gel-type dope of polyvinyl alcohol and a cross-linking agent wherein the interpenetrating network is located in the bearing carrier, and at least one additional therapeutic agent.

EFFECT: bandage may be applicable many times on various body parts.

21 cl, 4 dwg, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine. There are described methods for preparing biomaterials to be used as a woven sealant, complete sets containing precursors for preparing the biomaterials, and the resultant biomaterials. The biomaterials are prepared of the composition containing at least molecules of the first and second precursors, wherein: i) a molecule of the first precursor is a polymer of poly(ethylene glycol) having x nucleophilic groups specified in a group consisting of thiol or amine groups, wherein x is equal to 2 or more, preferentially 3, 4, 5, 6, 7 or 8; ii) a molecule of the second precursor is described by general formula: A-[(C3H6O)n-(C2H4O)m-B]i, wherein m and n represent integers within the range 1 to 200, i is more than 2, preferentially 3, 4, 5, 6, 7 or 8, A represents a junction point, B represents a conjugated unsaturated group.

EFFECT: biomaterials are able to glue tissue surfaces together quickly without complication of common therapy.

1 tbl, 10 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine. What is disclosed is a dosage form containing a base and a self-adhesive layer which contains a medicinal agent and covers at least one of the base sides; wherein the base consists of a polyester film of the thickness of 0.5 to 6.0 mcm, and a polyester non-woven material directly coupled with the film. The base is coated with the self-adhesive layer either directly or through an intermediate layer from the non-woven material.

EFFECT: adhesive preparation have sufficient elasticity for the purpose of tracking of the skin shape, as well as shows low ability to irritate the skin and high stability.

7 cl, 5 tbl, 7 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine; the flaking material (1) of the skin blister consisting of the material (10) for the body warm-up and the material (20) of the skin blister having the functional layer of the skin blister is described herein; in the material (10) for the body warm-up the flat layer (12) is formed for placing the exothermic agent (matter) (11), and on the lower surface of the layer (12) the second adhesive layer (14) is formed for placing the exothermic agent; the material (20) of the skin blister has the main layer (21) functioning as a basecoat for the material (20) of the skin blister and the functional layer (22) of the skin blister on the lower part of the main layer (21); the first adhesive layer (23) for attaching directly to the skin is formed on the lower surface of the functional layer (22) of the skin blister; the second adhesive layer (14) of the material (10) for the body warm-up is fixed to the upper surface of the main layer (21) of the material (20) of the skin blister to the effect that the main layer (21) and the material (10) for the body warm-up are conjoined with each other and the first adhesive layer (23) of the material (20) of the skin blister is attached to the skin; the adhesive power between the second adhesive layer (14) and the main layer (21) is less than the adhesive power between the first adhesive layer (23) and the skin.

EFFECT: material for the body warm-up can be repeatedly attached to the material of the skin blister.

5 cl, 1 tbl, 3 dwg, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to cosmetics, particularly to antiperspirants. The invention is characterised by a stable absorption pharmaceutical preparation for percutaneous introduction of a primary medicine, with the exception of selegelin and selegelin hydrochloride which is exposed to reduced cohesive forces of an adhesive layer even in the presence of the sweat component because of transpiration and which is free from cohesive destruction and residual adhesive when the preparation is removed. The absorption pharmaceutical preparation for percutaneous introduction contains: a substrate; and an adhesive layer containing an adhesive, metal chloride and a skin-absorbable drug, with the exception of selegelin and selegelin hydrochloride where the adhesive layer is cross-linked.

EFFECT: improved efficacy of the preparation.

8 cl, 18 ex

FIELD: medicine.

SUBSTANCE: claimed is application of desiccant for limiting testosterone decomposition, present in self-adhesive device of transcutaneous action, which placed in, in fact, airtight package, and said decomposition includes formation of admixtures as a result of oxidation and/or hydroxylation of testosterone. Desiccant application insures storage of said device during up to 36 month-long term.

EFFECT: reduction of androstenedine-dione by two times and other admixtures by 4 times after 30-month long device storage due to desiccant label DESIMAX®, placed inside of package.

11 cl, 6 tbl, 3 ex

FIELD: chemistry.

SUBSTANCE: invention relates to medicine. Described is an adhesive composition which is water-insoluble and water-absorbing, i.e. can absorb up to 15 wt % water or more. The composition consists of a hydrophilic film-forming polymer with at least one linear segment having several repeating polar groups along the polymer backbone chain, a complementary multifunctional polymer with several repeating functional groups which are not covalently bonded with the polar groups on the film-forming polymer, and a plasticiser. Described also is a method of preparing the adhesive composition.

EFFECT: adhesive composition adheres to a wet surface and does not dissolve or lose adhesiveness when it absorbs water.

68 cl, 27 dwg, 22 tbl, 13 ex

FIELD: medicine.

SUBSTANCE: invention refers to an application of hydrophilic biologically compatible adhesives in drug delivery systems, in wound dressings, in bioelectrodes and in the other systems wherein hydrophilic biologically compatible adhesives are desired. Particularly, the invention refers to water-swelling, water-insoluble polymers which in combination make the composition adhesive in moisture contact. in which a first water-swelling, water-insoluble polymer is cationic, a second water-swelling, water-insoluble polymer is anionic, and polymers are ion bonded to each other with forming a polymer matrix.

EFFECT: hydrophilic biologically compatible adhesives are adhered to a body surface with coherence preserved.

24 cl

FIELD: mechanics.

SUBSTANCE: invention relates to a sheet characterised by adhesion to textiles and containing a homogenous prepared and sewn matrix formed by one or multiple polymer(s) and having at least a single surface that is disclosed during usage; at least one of the polymers abovementioned is a synthetic polymer having additional functional groups of the first form; the above matrix sewing is done at the expense of some of the above functional groups of the first form while the other functional groups of the first form are free. The sheet is particularly applicable as a textile glue and as a sealing material and is intended for local overlay on the body inner and outer surfaces for medical purposes. The invention additionally relates to sheets containing a support material, 3D products moulded from a material similar to that of the sheet and implantable medical devices coated with such material.

EFFECT: sheet is noted for good initial adhesion to textile surface.

18 cl, 7 dwg, 2 tbl, 16 ex

FIELD: medicine.

SUBSTANCE: described is stable pharmaceutical preparation of absorption type for transcutaneous introduction, which includes bottom layer and adhesive layer, containing metal chloride, adhesive and at least one composition from (-)-(R)-N, α-dimethyl-N-2-propinylphenethylamine and its hydrochloride, where adhesive layer is subjected to crosslinking.

EFFECT: pharmaceutical preparation of absorption type for transcutaneous introduction of selegiline or selegiline hydrochloride does not suffer reduction of cohesive strength of adhesive layer even in presence of sweat components caused by excretion of sweat during wearing, and is free of cohesive destruction and remains of adhesive when preparation is removed.

4 cl, 2 tbl, 22 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine. What is described is an adhesive composition containing donepezil and a stabiliser. The stabiliser containing one or more compounds specified in a group consisting of ascorbic acid, metal salt or ester of such, isoascorbic acid or metal salt of such, ethylene-diamine-tetraacetic acid or metal salt of such, cysteine, acetylcysteine, 2-mercaptobenzimidazole, 3(2)-tert-butyl-4-hydroxyanisol, 2,6-di-tert-butyl-4-methylphenol, tetrakis[3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)]propionate pentaerythrite, 3-mercapto-1,2-propanediol, tocopherol acetate, rutin, quercetin, hydroquinone, metal salt of hydroxymethansulphinic acid, metabisulphite metal salts, sulphite metal salt and thiosulphate metal salts; it is added to a layer of a pressure sensitive adhesive applied on at least one side of the substrate.

EFFECT: prepared high reliable and stable adhesive composition which inhibits formation of donepezil-related compounds in the layer of the pressure sensitive adhesive.

14 cl, 4 tbl

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