Haemostatic clay agents and delivery devices

FIELD: medicine.

SUBSTANCE: invention refers to medicine. What is described is a haemostatic device for blood coagulation improvement which contains a gauze base, a clay material located thereon, and also polyol, such as glycerol or similar placed on the gauze base for binding the clay material. The device for bleeding wound management comprises at least a portion of the clay material contacting to blood flowing from the wound to cause coagulation. A dressing applicable on the bleeding wound for blood coagulation improvement comprises a flexible base and a gauze base located thereon. The gauze base comprises the clay material and polyol. Ahaemostatic sponge also contains a gauze basis and a disperse system of the haemostatic material and polyol on the first base surface. The invention also refers to N-substituted monomers and polymers, methods for producing such monomers and polymers and to methods for using for various medical purposes, e.g. in medical devices. In the preferential versions, a medical device represents a stent.

EFFECT: haemostatic device improves blood coagulation.

43 cl, 1 tbl, 9 dwg, 2 ex

 

SCOPE

The present invention generally relates to agents and devices for improvement of haemostasis and, in particular, to hemostatic agents on the basis of clay and devices containing such agents, for their delivery to the bleeding wounds.

The LEVEL of TECHNOLOGY

Blood is a liquid environment, which includes red blood cells, white blood cells, blood cells and platelets dispersed in the liquid phase. The liquid phase is plasma, which contains acids, lipids, soluble electrolytes and proteins. Proteins suspended in the liquid phase and can be separated from the liquid phase by any of several methods, such as filtration, centrifugation, electrophoresis and immunochemical techniques. One of the proteins suspended in the liquid phase, is fibrinogen. In case of bleeding, fibrinogen reacts with water and thrombin (enzyme) with the formation of fibrin, which is insoluble in the blood and the nails are polymerized with clots.

In many cases, the animals, including humans, may be injured. Often, these wounds are accompanied by bleeding. In some cases, such wounds and bleeding are minor, and the normal function of blood clotting in addition to providing simple first aid is all that is required. Unfortunately, in some cases is considerable the e bleeding. These situations usually require specialized equipment and materials, as well as staff with the skills to provide appropriate assistance. If such assistance is not readily available, there may be significant blood loss. If heavy bleeding occurs sometimes availability of equipment and professional staff is insufficient to stop the bleeding in time.

Moreover, serious wounds can often be applied in remote areas or situations, such as the battlefield where adequate medical care is not available immediately. In some circumstances, it is important to stop the bleeding, even with less serious wounds, on a period of time sufficient to ensure that the injured person or animal received medical assistance.

In an attempt to solve the above problems materials have been developed to control heavy bleeding in situations where normal services are unavailable or less than effective. Although these materials have demonstrated some success, sometimes they are not effective for traumatic wounds and are expensive. Moreover, these materials are sometimes ineffective in some situations and can hardly be used and removed from the wound.

Additionally or alternatively, the previously developed the haunted materials can have undesirable side effects. For example, one type of material for blood clotting from the prior art in General is a powder or fine particles, where the surface area of the material often leads to an exothermic reaction upon contact with blood. Often the excess material that is not necessary, gets into the wound, which can exacerbate exothermic effects. Depending on the specific material properties obtained exothermic reaction can be strong enough to cause discomfort or even burns to the patient. Although some sources in the prior art indicated that the resulting exothermic reaction is a desirable characteristic that can provide the effect of blood clotting in the wound like cauterization, there is the possibility that the tissue on and around the injured area may be desirable affected.

Moreover, for the removal of such materials from wounds often require washing. If the quantity of material used causes discomfort or burning that may require immediate washing of the wound. In cases where the injured person or animal is not yet transported to a facility that can provide adequate washing, adverse effects, or oversaturation of the wound can occur.

Bleeding is also a problem during the surgical process is ur. Not counting suturing or closing of incised wounds or internal bleeding area, bleeding often regulate, using a sponge or other material, used to provide pressure to the site and/or to absorb blood. However, when the bleeding becomes excessive, these funds are insufficient to stop the blood flow. Moreover, any material with a strong exothermic reaction to control bleeding may cause damage to the tissue surrounding the bleeding site, and may hardly be removed after use.

Based on the above, the General objective of the present invention is to provide a hemostatic agent, which will overcome or surpass the disadvantages associated with the prior art. Also the present invention is the provision of devices, is able to apply these hemostatic agents.

SUMMARY of the INVENTION

In accordance with one aspect, the present invention consists in a device to improve blood clotting, controlling bleeding. The device comprises a clay material in the form of particles and the reservoir for the content of clay material. At least part of the reservoir is defined by a mesh having openings so that when the device is applied to the bleeding area, particle ginecomastia blood through the holes.

In accordance with another aspect, the present invention is the other device capable of providing a hemostatic effect on the bleeding wound for regulating blood flow from the wound. The device comprises a gauze base (substrate) and clay material, located on the gauze basis. When applying the device to the bleeding wound, at least a portion of the clay material in contact with blood, causing the hemostatic effect.

In accordance with another aspect, the present invention consists in a dressing material that can be applied to the bleeding wound to improve blood clotting, controlling bleeding. This material contains a base (substrate), a grid mounted on the substrate, and particles of clayey material held in the grid. The grid is determined by many elements, posted with the definition of holes which allow the blood flow into the grid and clay material, causing thus the clotting of blood.

In accordance with another aspect of the present invention is a hemostatic sponge, which can be applied to a bleeding wound for blood clotting and to control bleeding. This sponge includes a base, a hemostatic material, located on the first surface of the substrate, and a release agent located the and the second substrate surface. A release agent is located on the substrate surface in contact with the wound, for the inhibition of the adhesion of the sponge to the tissue of the wound after the formation of a clot. When processing the bleeding wounds of the application of the hemostatic sponge causes at least a portion of the hemostatic material is in contact with the blood through the separating agent and through the base.

In accordance with another aspect of the present invention includes other forms of hemostatic sponges. In such forms a hemostatic sponge may include film and hemostatic material included in the film; the basis, the hemostatic material posted on it and film, located on the hemostatic material; or hemostatic material placed between two bases (substrates).

In accordance with another aspect of the present invention is a hemostatic device to improve blood clotting, controlling bleeding. The device comprises a gauze base (substrate), clayey material, located on the gauze basis, and also polyol, such as glycerol or the like, is placed on the gauze basis for binding of the clay material. When using the device for treatment of bleeding wounds, at least a portion of the clay material is in contact with the blood flowing from the wound, causing Shorty is the use of blood.

In accordance with another aspect of the present invention consists in a dressing material that can be applied to the bleeding wound to improve blood clotting, controlling bleeding. The material has a flexible basis and gauze-based, fixed on her. Gauze base includes a clay material and a polyol. When using bandages for treatment of bleeding wounds, at least a portion of the clay material is in contact with the blood flowing from the wound, causing blood clotting.

In accordance with another aspect of the present invention is a hemostatic sponge. One type of sponge gauze has a base and a disperse system hemostatic material and polyol on the first substrate surface. When using sponges for the treatment of the bleeding wound, at least a portion of the hemostatic material is in contact with the blood flowing from the wound, causing blood clotting. Another type of sponge has first and second bases. The hemostatic material is dispersed in the polyol and put on the first base and the second base is placed on the hemostatic material dispergirovannom in the polyol. When using this sponge for treatment of bleeding wounds, at least a portion of the hemostatic material is in contact with the blood, at least one of the substrate of the century

The advantage of the present invention is that, unlike other materials such as, for example, zeolites, clay component does not produce an exothermic reaction with blood. The elimination of heat generation on the wounded area is helpful to reduce discomfort and/or injury of the patient and may be particularly useful in the treatment of some patients, such as pediatric or geriatric patients, or in the processing of wounds located in sensitive or painful area.

Another advantage is that the clay can be finely divided and held on a variety of surfaces, making, thus, its use as a component in various devices for regulating the flow of blood. In particular, the clay can be used in the form of particles (e.g., held on the mesh or film) or it can be used in powder form (for example, deposited on the fibrous education gauze or sponges). In any embodiment of the present invention, the efficiency of clay in accelerating hemostasis of the wound is improved in comparison with similar agents that may be used in only one form (for example, in the form of particles of a certain size) to limit undesirable side effects, such as excessive exotic species in the chemical reaction.

Another advantage of the present invention is that the device and the agents of the present invention are easily applied to open wounds. In particular, when the hemostatic agent is held in mesh or similar device, or when it is included in the fibrous structure with the formation of gauze, the device may be easily removed from sterile packaging and placed or mounted directly at the points where the bleeding for blood clotting.

One of the advantages of using a polyol, such as glycerol in combination with clay (or any other hemostatic agent), is that often paleocristiana associated with clay (or other hemostatic agent), is suppressed. Because of its low volatility, glycerol, for example, evaporates easily. Because it is not easy to evaporate, the formation of clay dust in the dispersion of clay in glycerol decreases. The reduction or suppression of dust means that more hemostatice material available with the aim of coagulation.

Another advantage of using polyol in combination with clay (or other hemostatic agent) is the fact that undesirable adhesion of the sponge to the wound is reduced. Accordingly, sponge or other device may be easily removed from the wound without disturbing the integrity formed of sgus the ka blood.

BRIEF DESCRIPTION of DRAWINGS

Figure 1 is a schematic illustration of the mesh devices coagulation of the present invention.

Figure 2 is a side view of the device of the coagulation of figure 1, illustrating the retention of particles of clay in the net structure.

Figure 3 is a perspective representation of the device of coagulation, where the clay material included in gauze.

Figure 4 is a perspective representation of the device of coagulation, where the clay material is included in the fabric.

Figa is a perspective representation support bandages, where the clay particles are in mesh container for application to the bleeding wound.

FIGU is a perspective representation of the dressing material, where the hemostatic material and the polyol included in gauze basis for the application on the bleeding wound.

6 is a schematic illustration of a sponge having hemostatic abilities.

7 is a schematic illustration of another embodiment of the sponge with hemostatic abilities.

Fig is a schematic illustration of another embodiment of the sponge with hemostatic abilities.

Fig.9 is schematizes the second image of another embodiment of the sponge, having hemostatic abilities.

DETAILED DESCRIPTION of PREFERRED embodiments of the INVENTION

Disclosed here hemostatic device and hemostatic agents are applicable to the bleeding wounds to accelerate hemostasis. Hemostatic agents include clay materials or other materials based on silicon, which is in contact with a bleeding wound can reduce or stop blood flow through the absorption of at least part of the liquid phase of the blood, facilitating thus the collapse. However, the present invention is not limited to clay, because other materials, such as bioactive glass, biological hemostatic agents, molecular mesh materials, diatomaceous earth, and combinations of these, and the like, included in the scope of claims of the present invention and can be used in combination with clay or separately as a hemostatic agent.

As used here, the term "clay" refers to a crystalline form of hydrated aluminium silicate. The clay crystals have irregular form and insoluble in water. The combination of some types of clay with water can give a mass with a certain degree of plasticity. Depending on the type of clay and its combination with water can give colloid is spruce, having thixotropic properties.

In one preferred embodiment of the present invention, the clay is a kaolin, which includes the mineral kaolinite". Although the term "kaolin" is used here to describe the present invention, it is necessary to understand that kaolinite can also be used in combination with or instead of kaolin. However, the present invention is not limited also kaolin or kaolinite, since other materials included in the scope of claims of the present invention. Such materials include, without limitation, attapulgite, bentonite, and combinations of these materials, combinations of these materials with kaolin and/or diatomaceous earth and the like.

As used here, the term "kaolin" refers to the soft, natural aluminosilicate clay (and, more specifically, to a dioctahedral phyllosilicate clay), with the chemical formula Al2Si2O5(OH)4. Kaolin is a layered silicate mineral of natural origin, with variables tetrahedral sheets and octahedral sheets of aluminum octahedra, linked through oxygen atoms of hydroxyl groups. Kaolin contains approximately 50% aluminum, about 50% silicon and traces of impurities.

More preferably, the clay represents the t Adgarsky plastic clay ("ERK"), which is kaolin clay, rinsed with water; it is mined and processed in and near Edgar, Florida. Edgarski plastic kaolin has the desirable characteristics of plasticity, is refractory and when mixed with water gives a thixotropic clay suspension.

Kaolin according to the present invention can be mixed with or otherwise used in combination with other materials that provide additional properties of blood clotting and/or improving efficiency. Such materials include, without limitation, magnesium sulfate, metaphosphate sodium, calcium chloride, dextrin, combinations of these materials and the hydrates of the above materials.

Various materials can be mixed with, connected with or included in the kaolin to maintain an antiseptic environment on the wounded area or to provide functions that are additional to the function of blood clotting clay. Examples of materials that can be introduced, without limitation, are pharmaceutically active compounds such as antibiotics, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines (such as chlorpheniramine maleate, diphenhydramine hydrochloride, and promethazine hydrochloride), compounds containing silver ions or copper ions,combinations of these, and the like. Other materials that can be included to provide additional hemostatic properties include ascorbic acid, tranexamic acid, rutin, and thrombin. Herbal agents that provide desirable effects on the wounded areas, can also be added.

For use in the present invention, the kaolin or other clay material or diatomaceous earth) is preferably in the form of particles. As used here, "particles" include beads, pellets, granules, sticks, or any other surface morphology, or a combination of surface morphology. Regardless of the surface morphology of the particles have a size from about 0.2 mm (millimeters) to 10 mm, preferably from 0.5 mm to 5 mm and more preferably from 1 mm to 2 mm in effective diameter. However, the present invention is not limited to these sizes and other sizes of particles (for example, less than 0.2 mm) are also included in the scope of claims of the present invention. The particle size of the kaolin or other clay material or diatomaceous earth) may be so small that it can be considered as a powder. If the particle size is such that the material is considered as a powder, the powder can be very small (i.e. tactile imperceptible).

Clay particles can be produced by any of several well known JV the way. Such methods include mixing, extrusion, the formation of spherical particles, and the like. Equipment that can be used for mixing, extrusion and formation of spherical particles of clay, available from Caleva Process Solutions Ltd. in Dorset, UK. Other methods include the use of a fluidized bed or apparatus for granulating. Fluid layers to obtain particles of clay available from Glatt Air Technologies in Ramsey, new Jersey. Disk granulator to obtain particles of clay available from Feeco International, Inc. in green Bay, Wisconsin. Preferably the clay ekstragiruyut through a suitable granulating device. However, the present invention is not limited to these options, because other devices and methods for obtaining crushed clay is also included in the scope of claims of the present invention.

Clay ERK used in the present invention, pulverized, dried and calcined to approximately 600°C. to achieve a suitable homogeneous mixture of ERK with particle formation, a relatively high pressure is applied to the mass of ERK, using suitable mixing apparatus. To implement this process, the water content in the clay is measured and regulated to approximately 20% by weight to obtain a mixture that can be easily extruded and post-processing.

In EMA firing ERK to a temperature of 600°C, the material is sintered (glazes). Steklovanye (vitrification) is carried out by repeating cycles of melting and cooling to allow ERK (or other clay material) to turn into a glassy substance. With increasing number of cycles the crystalline structure is destroyed with obtaining an amorphous composition. The amorphous nature ERK allows him to maintain structural integrity during subsequent hydration. As a result, the ERC maintains structural integrity when wet during use, for example when in contact with blood. However, the present invention is not limited to the use of plutocracy clay, as other materials that are not steklovata, also included in the scope of claims of the present invention. In particular, postelvinay clay can still be used when the bleeding wound with providing hemostasis.

It is clear that the cellular mechanism of coagulation of clay activates precise contact factors when applied to blood. In particular, believe that kaolin (preferably ERK) initiates the mechanism by which water is absorbed in the blood, facilitating the folding feature.

Figure 1 shows one of the options hemostatic device, where included kaolin in the form of particles. The device is a permeable pouch, which allows the fluid to contact with h stirami kaolin, held in it. Sealed package (not shown) provides a sterile environment for storage hemostatic device as long as it is not used. The device, which is shown under number 10, referred to hereinafter as the "bag of 10", includes a lattice or grid 12 and crushed kaolin 14 held in the bag grating or grid. The grid 12 is closed on all sides and defines openings that are able to hold crushed kaolin 14 therein while allowing fluid to flow through it. As illustrated, the grid 12 is smooth and as an example, only a few particles of crushed kaolin 14 is shown. Crushed kaolin 14 may be mixed with particles of another type of clay, diatomaceous earth and the like with the formation of a homogeneous mixture.

The grid 12 is defined by interconnected weaving, threads or strips of material. Weaving, threads or strips can be interconnected in any one or combination of methods, including, without limitation, bound in gauze, twisted, integrally formed, and the like. Preferably the connection is such that the grid can bend while maintaining the size of the holes defined her. The material from which the weaving, yarn, strips do can be a polymer (in the example, nylon, polyethylene, polypropylene, polyester and the like), metal, fiberglass or organic matter (e.g., cotton, wool, silk and the like).

Figure 2 openings defined by the grid 12 are of a size for holding powdered kaolin 14, but allows the flow of blood to flow through them. Because the grid 12 may be tightly stretched around the crushed kaolin 14, the particles may extend through the holes on the distance d. If the particles extend through the holes, they will directly contact with the fabric, that bag 10 is applied. Thus, blood flowing from tissue immediately in contact with crushed kaolin 14, and the aqueous phase is absorbed into the clay, making it easier for blood clotting. However, the present invention does not require that the particles are swollen through the mesh.

For the application of the bag 10 on the bleeding wound pouch is removed from the packaging and placed on the bleeding wound. Crushed kaolin 14 in the grid 12 is in contact with the tissue of the wound and/or blood flowing from the wound, and at least part of the liquid phase of the blood is adsorbed by clay material, improving coagulation. The flexible grid 12 allows it to conform to the shape of the bleeding wound and keep this form in the application.

Figure 3 shows another variant of implementation of the hemostatic devices present ademu the invention, which is a kaolin gauze, designated as number 20, hereinafter referred to as "gauze 20". Kaolin cover the gauze base (substrate), using any suitable method to obtain the gauze 20. For example, one method of application of kaolin on a gauze is based on the immersion of the substrate in the clay slurry kaolin/water. Kaolin material used for clay suspensions, preferably is a finely ground kaolin powder, though the invention is not limited to this material, because kaolin particles, plates, chips, balls, sticks, granules and the like may alternatively or additionally be used. Gauze base may be any suitable woven or nonwoven fibrous material, including without limitation, cotton, silk, wool, plastic material, cellulose, viscose, polyester, combinations of these, and the like. However, the presented invention is not limited to woven or non-woven fibrous material as gauze bases, since non-woven material, and similar materials are also included in the scope of claims of the present invention.

However, gauze 20 of the present invention is not limited to kaolin, as other clays, such as attapulgite, bentonite and their combinations can be used instead of or in addition to the kaolin. Moreover, other materials, silicon-based, bioactive glass, diatomaceous earth, and combinations of these, and the like can also be used in addition to or instead of any of the above clayey materials.

After the clay dried gauze on the basis of education gauze 20, gauze is sufficiently flexible to permit its bending, folding, or other manipulations for packing.

The flexibility of the basics of gauze 20 allows the gauze to take the shape of the bleeding wound and to retain the shape of the bleeding wound in the application.

One of the ways deposits of kaolin (or other clay material)covering the gauze basis, involves the heating of the clay slurry kaolin/water. Preferably, the suspension is heated to boiling, as higher temperatures facilitate the adhesion of the kaolin to the substrate. However, the present invention is not limited to this procedure, because the suspension can be heated to a lower temperature depending on the desired characteristics of the coating kaolin. Boiling suspension also provides effective form of mixing that allows uniformly distribute the kaolin in the liquid phase.

Then, the substrate is immersed in boiling the suspension for a period of time sufficient for deposits of kaolin on the substrate. Considering the rheology of wet kaolin and material gauze or substrate, kaolin may stick in the form of a film directly to the surface of the substrate or it may accumulate in the interstices of the weave themselves along the weave, attached to the fibrous matrix.

Another way of deposits of kaolin, covering the substrate includes applying kaolin in the form of suspension on one side of the gauze basis, using the technique of sputtering, spline method for the extrusion of films and bands, or a combination of both. When using any equipment, the amount of slurry applied to the surface of the substrate is limited in order to avoid or to minimize the saturation of the substrate. Preferably the colloidal form of kaolin (or other clay material) is used to provide a stable suspension of the material with suitable viscosity for use in slotted extrusion method.

After spraying or applying spline method is covered with a gauze substrate is then rolled or cut to consolidate kaolin on the substrate. Then gauze dried basis.

In some embodiments of the invention, the kaolin can be attached to the gauze basis, using a binder. In embodiments where the binding substance is used, the material this is about the substance is compatible with biological tissue. Preferred binders include polyols, chitosan and polyvinyl alcohol, all of which have adhesive properties and is compatible with biological tissue. In addition, chitosan exhibits hemostatic properties.

For example, one way to obtain this device may include the stage of unwinding the gauze from the shaft, the immersion of this gauze in suspension hemostatic material and water, applying pressure to the gauze by rolling the wet gauze under high pressure for the introduction of a hemostatic material in the material gauze, drying folded moist gauze and remove dust with gauze (for example, by blowing through an air knife or air nozzle, through the use of electrostatic energy, vacuuming or brushing direct contact). After the removal of dust with gauze gauze again wound on the shaft or it may be cut into sheets for individual packaging.

One or more variables can be modified to optimize the quantity and integrity of kaolin, held on the gauze. These variables include, without limitation, the temperature of the suspension, the dive time, the method of mixing the suspension liquid (suspension). The increase in the temperature of the suspension, as described above, contributes to the retention of kaolin on the gauze. Mixing can be intensificar the Vano by blowing air or other gas through the nozzle, agitation, bubbling, boiling, or ultrasonic vibration.

The liquid used for the suspension, may also be something other than water. For example, the fluid may be an aqueous solution of ammonia. An aqueous solution of ammonium causes swelling of some fibrous materials, such as materials commonly used for the manufacture of gauze.

In embodiments of the invention, where the polyol is used in the gauze 20, the polyol may be a glycerol (also known as glycerin, pillowy alcohol and its chemical name propane-1,2,3-triol). Glycerol is a viscous, hygroscopic, water-soluble liquid that is compatible with biological tissue. Kaolin is dispersed in the glycerol with the formation of a disperse system, or otherwise mixed with glycerin and deposited on the gauze substrate using any suitable method. Appropriate ways of sediment dispersal systems kaolin/glycerol on the gauze basis include, without limitation, the deposition of the dispersed system, soaking gauze basis in the dispersion system, application through slotted extrusion method, physical means, such as drawing with brushes or rolling disperse system on the gauze and the like.

However, the present invention is not limited to the use of glycerol, the Kolka other compounds on the basis of glycerol, including glycerole alcohols (for example propylene glycols), esterified fatty acids on the basis of glycerol (e.g., glyceryltrinitrate), and other materials having moisturizing properties and the like (also combinations of these) are included in the scope of claims of this invention. Moreover, other polyols, such as sorbitol, xylitol, malitol, combinations of these, and the like, polymer polyols (for example, Polydextrose) are included in the scope of claims of the present invention.

4 shows another variant of implementation of the hemostatic device of the present invention, representing a fabric having hemostatic properties, indicated by the number 30, which is hereafter referred to as "fabric 30". The fabric 30 is a material, which can be determined woven or non-woven strands or woven material, or the like, which is aged or impregnated biological hemostatic material. Hemostatic materials that can be inserted or embedded in the fabric material 30 include, without limitation, clays (such as kaolin) in the form of particles 32, other materials based on silicon (such as diatomaceous earth, combinations thereof or the like), chitosan, and combinations of these, and the like. In which the variants of implementation, where such materials are introduced, or ukrepliaiut in the fabric, the material is preferably introduced into the tissue in a hydrated state and then dried.

In the embodiment, a gauze or cloth, gauze or fabric material may be cross-stitched with polysaccharide or similar material.

On figa shows another variant of implementation of the present invention, representing dressings, identified by the number 50, which includes crushed kaolin 14 (or some other clay material or diatomaceous earth), held in the grid 12 and is fixed on the flexible substrate 52, which may be applied to the wound (e.g., using a pressure-sensitive adhesive for bonding material 50 to the skin of the carrier). The grid 12 is sewn, glued or otherwise attached to the substrate 52 for receiving the dressing material 50.

The substrate 52 is a plastic or fabric element that helps keep the skin wounded person or animal on or directly next to the bleeding wound. Adhesive (glue) 54 is placed on the surface of the substrate, which is connected with the skin of a wounded person or animal. In particular, if the substrate 52 is neosupervital plastic material, it may contain holes 56 for dispersal of power and, evaporating from the skin surface.

On FIGU another variant of the dressing material is shown, indicated by the number 150. Dressings 150 contains crushed kaolin (or some other clay material or diatomaceous earth, is capable of hemostatic function)dispersed in glycerol and applied on a gauze base 112. Gauze base 112 is fixed on the flexible substrate 152, which may be applied to the wound (e.g., using self-adhesive material 154, situated on top of all skin contact surfaces of the flexible substrate 152 for bonding material 150 to the skin of the carrier). Gauze substrate 112 is sewn, glued or otherwise attached to the substrate 152, which may be a plastic or fabric element containing holes 156. A separating agent (for example, polyvinyl alcohol, glycerol, carboxymethyl cellulose and the like) may be located on top of a disperse system kaolin/glycerol on the gauze base 112.

Figure 6 shows another variant embodiment of the invention, which is a sponge, indicated by the number 60, which contains a substrate (base) 62, crushed kaolin 14 (or some other clay material or diatomaceous earth) is placed on one surface of the substrate 62 and a separating agent 64, p is sporogony on the opposite side of the substrate. The sponge 60 provides sufficient contact of the crushed kaolin 14 with blood flowing from the wound through a separating agent 64 and the substrate 62, simultaneously reducing the adhesion of the sponge to the wounded tissue. The sponge 60 is also compatible with living tissue.

The substrate 62 is an absorbent gauze material, which defines a matrix. However, the present invention is not limited to this material, since other materials, such as mixtures of viscose/polyester cellulose and the like are also included in the scope of claims of the present invention. Other materials from which the substrate 62 can be made, include a fabric material, non-woven material, paper (e.g., Kraft paper and the like) and cellulosic material (e.g., cotton in the form of balls, tampons and the like). Any material from which the substrate 62 can be manufactured, may have an elastic property. When an elastic material is used as the substrate 62, the sponge 60 is a hemostatic device, and a tight bandage, in particular in embodiments where the surface cohesive agent or a mechanical clamp type, in order to ensure that the sponge just above the wound.

The hemostatic agent used in the sponge 60 is not limited to crushed kaolin 14. Other materials, such as attapulgite, bentonite, a combination thereof or a combination thereof with kaolin can be used. However, the present invention is not limited to these materials, since other materials, such as bioactive glass, biological hemostatic agents, diatomaceous earth, and combinations thereof, combinations thereof with clay also included in the scope of claims of the present invention.

Crushed kaolin 14 may be associated with the substrate 62 Coulomb forces, by impregnation or incorporation of clay or other hemostatic material directly to the substrate material using a binder, by seizing the hemostatic material matrix, or the like.

When using a binder to bind the crushed kaolin 14 with the substrate 62 connecting material can provide additional functional properties of the sponge 60. The materials from which made the binder may include, without limitation, chitosan, polyvinyl alcohol, guar gum, klasterizovannykh starch, polysaccharides, cellulose, calcium alginate, and the like, and combinations of the above.

In the variants of implementation, where the crushed kaolin 14 is introduced into the substrate 62 directly, crushed kaolin may be added during manufacture of the substrate. If the subst is the ATA is a non-woven gauze material, containing viscose and polyester, crushed kaolin 14 may be inserted in or on the fibers of viscose and polyester. For example, powdered kaolin 14 may be in powder form and added to the molten polyester, and polyester fibers can be pulled from the melt polyester/hemostatic material. If the substrate is a woven gauze (e.g., cotton), kaolin 14 in the form of powder may be included in the cotton strands during their formation.

Crushed kaolin 14 may also be dispersed in glycerol and applied to the substrate 62 by means of evaporation, splined way of extrusion, soaking, application by brush, roll or the like.

A separating agent 64 is a material located on a side of the substrate 62 in contact with the wound, to facilitate extraction of the sponge 60 of wounded tissue after the formation of blood clots. A separating agent 64 may be a continuous film or may be interrupted on the surface of the substrate. One material that can be used as a separating agent is a polyvinyl alcohol, the alcohol is a biocompatible material and can form a thin film, without exerting significant influence on the absorption and moisture permeability of the sponge 60. Another material that can be used in quality is ve separating agent 64, represents glycerol, which can be applied in addition to crushed the kaolin, dispergirovannom in glycerol. When used as a separating agent, glycerol forms a film over a disperse system crushed kaolin 14 in glycerol. Other materials that can be used as separating agents include, without limitation, carboxymethyl cellulose. In any configuration of the sponge 60, a separating agent 64 may be applied directly to the surface of the substrate 62 in contact with the wound.

Alternatively, a separating agent 64 may be deposited on the surface of the substrate 62, not in contact with the wound, in the form of a suspension of clay and separating agent. In this embodiment of the invention, the concentration of polyvinyl alcohol or glycerol is such that at least part of some of the components of the alcohol seeps to the surface of the substrate 62 in contact with the wound, while the clay material remains or remains near the surface, not in contact with the wound. In any embodiment of the invention, polyvinyl alcohol or glycerol serves not only as a separating agent, but as an agent, which removes the dust from the crushed kaolin 14.

However, other materials that can be used in quality is ve separating agents, the components of the scope of claims of the present invention, include, without limitation, silicone and klasterizovannykh starch. Together with polyvinyl alcohol and glycerol, or applied in the form of a film.

The sponge 60 also includes a feature that gives it a radiopaque property. In this embodiment, the barium sulphate may be introduced into the suspension, which contains crushed kaolin 14, and deposited on the substrate 62.

The sponge 60 may also contain water or alcohol, so the sponge can be used as napkins.

7 shows another variant of implementation of the sponge, indicated by the number 160. Sponge 160 includes film 162, in which the crushed kaolin 14 dispersed. The physical integrity of the sponge 160 supported film 162. Preferably the material from which the film perform, is a polyvinyl alcohol. In the manufacture of sponge 160 crushed kaolin 14 is dispersed in polyvinyl alcohol, which is formed in the sheet. Sponge 160 is particularly useful when it is introduced in bandages.

On Fig another variant implementation of the sponge shown, indicated by the number 260. Sponge 260 includes a substrate 262, crushed kaolin 14 located on the substrate and the film 266, located above the hemostatic material. Crushed kaolin 14 is nesv is connected (without binders) coagulating the blood agent and preferably is located on the substrate 262 strips to facilitate bending of the jaws 260. Film 266 is polyvinyl alcohol, gylcerol or the like and is used to enable crushed kaolin 14, and to reduce dust formation. When applied to the bleeding wound, the blood seeps from the wound to the substrate 262 and is in contact with crushed kaolin 14.

Figure 9 is another variant of implementation of the sponge shown, indicated by the number 360. Sponge 360 contains crushed kaolin 14 placed between the two substrates 362. Substrates 362 may be connected together by any suitable means, such as heat-sealable areas where crushed kaolin is missing, using an adhesive (glue) or binder in selected areas, a protective film material (such as polyvinyl alcohol) over the entire sponge 360 or a combination of the above. Crushed kaolin 14 may be used in combination with glycerol, for example by dispersion in glycerol and applied to the sponge 360.

The sponge 60 (as well as sponges, designated 160, 260, 360) can be folded and used in different ways. The sponge 60 can be folded so that the surface is crushed kaolin 14 represent the inner surface of the folded sponge to reduce the problem of dust formation and separation of the hemostatic material from the substrate 62. The sponge 60 (and sponge 160, 260, 360) are also shown is to be folded in a corrugated form or in the form to get a number of different folds, United along the edges. If you change the shape of the sponge 60, requirements, compliance and absorption for different applications can be solved. The sponge can be cut or be in the form of elongated strips to wrap around wounds wounded person or animal or for injection into the cylinders or tampons. The sponge 60 can also be cut, split, divided or otherwise separated into small fragments for applications such as filling mesh containers.

Example 1. The influence of the temperature of the suspension on the ability of the cotton gauze to keep kaolin clay.

The temperature of the suspensions of kaolin/water were modified to assess the ability of cotton gauze to keep kaolin clay. Suspension of water and ERK were prepared, the weight of the kaolin accounted for 40% of the total weight of the suspension. Three sponges were performed (one for each piece of gauze) by immersing the cotton gauze in suspension at different temperatures, wet sponges were laminated under pressure and dried. The table below shows the settings for each suspension, and the obtained results.

SampleThe temperature of the suspension (degrees C)The method of mixingThe initial weight of the gauze (grams) The weight of the gauze after (grams)% kaolin (by weight)
122mixing 1 minute3.1395.5944
290mixing 1 minute3.0645.86848
3100boil 1 minute3.0856.48152

The weight of the gauze after represents the weight of the gauze after rolling and drying. It should be noted that the increased temperature of the suspension increases the number of retained kaolin. One explanation for this is that the structure of the cotton fiber gauze fades and swells when immersed in hot liquid.

Example 2. Application of dry kaolin on a dry cotton gauze with getting the hemostatic device

Dry kaolin was applied on dry cotton gauze. The gauze was folded. The amount of the kaolin held on the gauze, was markedly and significantly less kaolin, held on the gauze Sample 3 (Example 1). is the sample however, accelerated the clotting time of whole blood sheep by 70% compared to non-accelerated the clotting time of blood.

Example 3. Reduction of kaolin dust when using glycerol

A suspension of 50 grams (g) of water, 20 g of glycerol and 15 g of kaolin powder were prepared and used to saturate gauze sponges (Kendall Curity 2733). The saturated sponge was dried. Sponge kept and knocked on it with a pencil on a clean glass surface. Visual determination showed that the easily visible dust was not removed with the sponge in the result of obstuctive.

The second sponge prepared without glycerol and dried. Sponge kept and knocked on it with a pencil on a clean glass surface. Visual determination showed that a significant amount of kaolin dust was removed as a result of obstuctive.

Although the present invention is shown and described in respect to detailed embodiments, the person skilled in the art understand that various changes may be made and equivalents may be substituted for elements without departure from the scope of the claims. Additional modifications can be made to adapt a particular situation or material to the disclosure of the invention without departure from the invention. Thus, it is clear that the invention is not ogranichivayas the specific implementation options, disclosed in the detailed description, but the invention includes all embodiments of covered by the scope of the claims appended claims.

1. The device is capable of providing a hemostatic effect on the bleeding wound, where the specified device includes:
gauze basis;
clay material located on the gauze; and
water-soluble polyol as one binder hosted on this gauze basis for associating the specified clay material with the specified gauze basis;
where gauze basis initially exists separately from the clay material until such time as the gauze and the clay material are joined;
where the polyol as one binding substance has the effect of significantly suppressing clay dust; and
where the specified device is dry, and the device has such a configuration that the treatment of the bleeding time, such devices can cause contact at least part of the clay material with blood to promote blood clotting.

2. The device according to claim 1, where specified, the clay material is kaolin.

3. The device according to claim 1, where the specified clayey material selected from the group consisting of attapulgite, bentonite, kaolin, and combinations of the above mA the materials.

4. The device according to claim 1, also comprising diatomaceous earth, located on the specified gauze basis.

5. The device according to claim 1, where the specified clay material also contains a material selected from the group consisting of magnesium sulfate, metaphosphate sodium, calcium chloride, dextrin, hydrates of the above materials and combinations of the above materials.

6. The device according to claim 1, where the specified clay material also contains a pharmaceutically active composition selected from the group consisting of antibiotics, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines, compounds containing silver ions or copper ions, and combinations of the above compositions.

7. The device according to claim 1, where the specified gauze base is made from a material selected from the group consisting of cotton, silk, wood, plastic, cellulose, viscose, polyester and combinations of the above materials.

8. The device according to claim 1, where the specified gauze framework is flexible, allowing it to take the form indicated the bleeding wound and to retain the shape of this wound.

9. The device according to claim 1, where the specified clay material is dispersed in the specified water-soluble polyol as one binding substance and placed on a specified basis.

10. Give the TWT according to claim 1, also contains a separating agent, located on the specified clayey material.

11. The device of claim 10, where the specified separating agent selected from the group consisting of polyvinyl alcohol, glycerol, silicone, carboxymethylcellulose and castelsilano starch.

12. The device of claim 10, where the specified separating agent is a film formed over the specified clayey material.

13. The device according to claim 1, where the specified clay material contains particles having a diameter of approximately 0.2 mm to 10 mm

14. The device according to claim 1, where the specified clay material contains particles having a diameter of approximately from 1 mm to 7 mm

15. The device according to claim 1, where the specified clay material contains particles having a diameter from about 2 mm to 5 mm

16. The device according to claim 1, where the specified clay material contains particles having a diameter less than 0.2 mm

17. The device according to claim 1, where the aforementioned water-soluble polyol as one binder selected from the group consisting of glycerol, compounds based on glycerol, sorbitol, xylitol, malitol, polymer polyols, and combinations thereof.

18. The device 17, where the specified polymeric polyol is Polydextrose.

19. The device 17, where the connection specified on the basis of glycerol selected from the group consisting of p is epilepidota, glyceryltrinitrate and combinations of the above.

20. Dressings applied to the bleeding wound, where specified material includes:
a flexible basis;
gauze base, fixed on the specified flexible basis; and
clay material located on this gauze basis; and
water-soluble polyol as one binder hosted on this gauze basis for associating the specified clay material with the specified gauze basis;
where gauze basis initially exists separately from the clay;
where the polyol as one binding substance has the effect of significantly suppressing clay dust; and
where the specified device is dry, and the device has such a configuration that the treatment of the bleeding time, such devices can cause contact at least part of the clay material with blood to promote blood clotting.

21. The dressing material according to claim 20, where specified, the clay material is kaolin.

22. The dressing material according to claim 20, where the specified clayey material selected from the group consisting of attapulgite, bentonite, kaolin, and combinations of the above materials.

23. The dressing material according to claim 20, where the specified clay material also contains material that is selected from the group consisting of magnesium sulfate, metaphosphate sodium, calcium chloride, dextrin, hydrates of the above materials and combinations of the above materials.

24. The dressing material according to claim 20, where the specified clay material also contains a pharmaceutically active composition selected from the group consisting of antibiotics, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines, compounds containing silver ions or copper ions, and combinations of the above compositions.

25. The dressing material according to claim 20, also comprising an adhesive on the basis of the specified adhesive facilitates the retention of this material on the skin of the media.

26. The dressing material according to claim 20, where specified, the clay material is dispersed in the specified water-soluble polyol as one binding substance and placed on the specified gauze basis.

27. The dressing material according to claim 20, where the aforementioned water-soluble polyol as one binder selected from the group consisting of glycerol, compounds based on glycerol, sorbitol, xylitol, malitol, polymer polyols, and combinations thereof.

28. The dressing material according to item 27, where the connection specified on the basis of glycerol selected from the group consisting of propylene glycols, glyceryltrinitrate and combination the above-mentioned compounds.

29. The dressing material according to claim 20, also comprising a separating agent, is placed above the specified clayey material, and a specified water-soluble polyol as one binder, located on the specified gauze basis.

30. The dressing material according to clause 29, where the specified separating agent selected from the group consisting of polyvinyl alcohol, glycerol, silicone, carboxymethylcellulose and castelsilano starch.

31. A hemostatic sponge, including:
gauze base having a first surface; and
disperse system hemostatic clay material and water-soluble polyol as one binder located at the said first surface specified gauze substrate;
where gauze basis provided separately from the clay in the manufacture of sponge;
where water-soluble polyol as one binding substance has the effect of significantly suppressing clay dust; and
where the specified device is dry, and the device has such a configuration that the treatment of the bleeding time, such devices can cause contact at least part of the clay material with blood to promote blood clotting.

32. A hemostatic sponge on p, also containing a release agent, located, according to what ina least on one of these surfaces gauze substrate and dispersed systems hemostatic material and a water-soluble polyol as one of the binder.

33. A hemostatic sponge on p where specified hemostatic material is kaolin.

34. A hemostatic sponge on p where specified hemostatic material selected from the group consisting of attapulgite clay, bentonite compounds, preventing clay, kaolin clay, bioactive glass, biological hemostatic means, diatomaceous earth, and combinations of the above.

35. A hemostatic sponge on p where the specified separating agent selected from the group consisting of polyvinyl alcohol, glycerol, silicone, carboxymethylcellulose and castelsilano starch.

36. A hemostatic sponge on p, where the aforementioned water-soluble polyol as one binder selected from the group consisting of glycerol, compounds based on glycerol, sorbitol, xylitol, malitol, polymer polyols, and combinations thereof.

37. A hemostatic sponge on p, where the connection specified on the basis of glycerol selected from the group consisting of propylene glycols, glyceryltrinitrate and combinations of the above.

38. A hemostatic sponge, including:
the first gauze basis;
hemostatic clayey material dispersed in motorstv the Rome polyol as one binding substance and applied to the specified first gauze basis; and
the second key is located on the specified hemostatic clay material, dispergirovannom in the specified water-soluble polyol as one binding substance;
where the specified device is dry, and the device is configured such that during processing of bleeding, use this hemostatic sponge is able to call the contact, at least part of the clay material with the blood through one of the first framework and the second framework.

39. A hemostatic sponge according to § 38, where the specified hemostatic clay material selected from the group consisting of attapulgite clay, bentonite compounds, preventing clay, kaolin clay, bioactive glass, biological hemostatic means, diatomaceous earth, and combinations of the above.

40. A hemostatic sponge according to § 38, containing a release agent located on the specified hemostatic clay material, dispergirovannom in the water-soluble polyol as one binding substance.

41. A hemostatic sponge on p where the specified separating agent selected from the group consisting of polyvinyl alcohol, glycerol, silicone, carboxymethylcellulose and castelsilano starch.

42. A hemostatic sponge according to § 38, where the aforementioned water-soluble polyol as one binder selected from the group consisting of glice the Ola, compounds based on glycerol, sorbitol, xylitol, malitol, polymer polyols, and combinations thereof.

43. A hemostatic sponge in § 42, where the connection specified on the basis of glycerol selected from the group consisting of propylene glycols, glyceryltrinitrate and combinations of the above.



 

Same patents:

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to medicine, namely to application of copolymer of 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propansulfonic acid salt and 2-hydroxyethyl ester of propenoic acid as agent for release of active substance in composition for bandage. Invention also relates to bandages, containing at least one adipose substance and/or elastomeric matrix and at least one active substance, which also contain said copolymer.

EFFECT: active agent, included into bandage composition, is not toxic for cells, in particular, fibroblasts, and does not influence properties of cohesion, absorption or adhesion of compositions.

25 cl, 1 dwg, 10 tbl, 18 ex

Transdermal plaster // 2445123

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, particularly pharmaceutical preparations, namely: plasters for transdermal application. What is described is a transdermal plaster representing a matrix system and comprising a lining layer, a matrix layer and a lightproof protective coating in the following proportions: mexidol substance (4.59 wt %), propylene glycol 10.32 wt %, PVP K90 (Plasdone K90) 10.09 wt %, 95% ethanol 75.0 wt %. The plaster aims at the transdermal introduction of mexidol. A plaster area is 25 cm2.

EFFECT: plaster is used for treating and preventing chronic diseases, allows avoiding the problems related to oral administration, improves patient compliance; it is applicable in children and elderly persons, suitable for purposes of combination therapy.

5 dwg, 1 tbl

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to surgery, and is intended for pathogenically substantiated treatment of wounds of various etiology at the first stage of wound process. Described is application in wound covering of single complex from perforated cellulose Acetobacter xylinum and biologically active ingredients, which have therapeutic effect. Into wound covering included are complex fullerene C60/Tween-80 (antioxidant), antimicrobial component, antienzymatic and haemostatic component, necrolytic component.

EFFECT: due to wet medium supplied are optimal for wound reparation conditions, and due to application of perforated bacterial cellulose covering is vapour- and air permeable.

4 cl, 2 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: invention relates to transdermal therapeutic system, which contains, at least, one easily volatile and/or thermolabile biologically active substance and/or auxiliary substance, which can be obtained by limiting on each other of, at least, three components, namely, polymer matrix layer, acceptor layer, absorbing with high speed biologically active substance and/or auxiliary substance, as well as donor-layer, which by the moment of manufacturing contains volatile and/or thermolabile biologically active substance and/or auxiliary substance. During or immediately after lamination process, donor-layer by means of migration of volatile and/or thermolabile substances combines with acceptor layer.

EFFECT: transdermal therapeutic system ensures improved gastrointestinal tolerance.

12 cl, 1 tbl, 1 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, more specifically to dressing used for closure and treatment of burns, wounds of various aetiology, trophic ulcers, decubitus ulcers, etc. What is described is a bandage in which three components are used: a wound-facing nontraumatic textile layer with antiseptic butole in the concentration 0.05 mg/cm2 to 1.0 mg/cm2 in a therapeutic layer which is coated with a replaceable sorptive layer made of a nonwoven fabric and providing sorption power of the bandage within 15 g/g and 10 g/g once changed. The replaceable sorptive layer is fixed between the therapeutic and sorptive layers by means of an adhesive frame which is a third component, e.g. made of a nonwoven fabric 0.1-0.5 mm thick and 6.0-10.0 mm wide; both surfaces of the frame are coated with a therapeutic adhesive, and an outer size of the framework is equal to a length and a width of the therapeutic layer. The therapeutic layer additionally contains drugs of haemostatic, anaesthetising, antioxidant and/or wound healing action.

EFFECT: production of the sustained-action bandage with extended spectrum of antimicrobial action, improved antimicrobial activity and higher sorption power.

2 cl, 1 tbl

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to ophthalmology. The invention discloses methods for detecting release and absorption rates of pharmaceutical drugs contained in eye lenses.

EFFECT: invention provides detection of continuous penetration rates of pharmaceutical drugs through eye lenses.

23 cl, 1 dwg, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to wound coverings with using a human cell material. Substance of the invention is integrated use for repair of wounds of different area and a volume of hydrated microbial cellulose with a stratified collagen gel, and one growth factor source is found in layers or at the interface. The growth factor sources are mesodermal and/or ectodermal cells and/or blood thrombocytes. There are offered combinations and optimal proportions of the cell material providing a high therapeutic effect of the declared wound covering. Under the invention, there are prepared biologically active wound coverings containing fibroblasts, blood thrombocytes, mesenchymal stem cells, human postnatal keratinocytes.

EFFECT: wound covering combines a function of biologically active matrix for tissue regeneration and a function of wound surface protection and hydration.

37 cl, 6 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of medicine, namely to bandage means, used for treatment of burns, trophic ulcers and other skin lesions, as well as to methods of their obtaining. Described is gel, representing sparsely-cross-linked chitosan and polyanionic hydrocolloid polymer, which has 2-3 linkages of copolymers per chitosan molecule, and distributed in it auxiliary substances. As polyanionic hydrocolloid, used is suspension of sucralfate or polyalginic acid particles, containing 0.01-15 wt % of stabiliser. As stabiliser used is highly molecular polyalcohols, such as polyvinyl alcohol, polyethylene glycol, as well as polyvinylpyrrolidone or silver microparticles. Auxiliary substances are introduced into gel individually or together in concentrations from 0.01 to 30% of gel dry weight. Gel is obtained by mixing chitosan with polyanionic hydrocolloid, into which preliminarily introduced were stabiliser and auxiliary substances. Bandage material represents hydrogel layer, applied on biocompatible film from water-insoluble polymer with pores with diameter D=(0.01-5.0) mcm. Covering can be on wounds during long term from 2 to 20 days and produce medicinal effect during said period.

EFFECT: bandage means can be used in treatment of trophic ulcers and various wound types, including wounds polluted with microorganisms, trophic wounds and prolonged non-healing wounds, and also be applied as allogen skin substitute in operations aimed at recovery of skin in patients with extensive burns.

16 cl, 11 ex

FIELD: medicine.

SUBSTANCE: claimed is application of desiccant for limiting testosterone decomposition, present in self-adhesive device of transcutaneous action, which placed in, in fact, airtight package, and said decomposition includes formation of admixtures as a result of oxidation and/or hydroxylation of testosterone. Desiccant application insures storage of said device during up to 36 month-long term.

EFFECT: reduction of androstenedine-dione by two times and other admixtures by 4 times after 30-month long device storage due to desiccant label DESIMAX®, placed inside of package.

11 cl, 6 tbl, 3 ex

Haemostatic plaster // 2417076

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, namely to local haemostatic bandaging materials, and can be used in medical and preventive health care facilities. A haemostatic plaster contains a bottom layer of two design versions oriented to contact skin of various sensitivity: supersensitive skin requires thermomelting hypoallergenic non-continuous glue, while skin of moderate sensitivity, a glue of the following composition is used: lump rubber - 12.85 %, synthetic rubber - 12.85 %, pine rosin - 20.35 %, lanolin - 9.9 %, zinc oxide - 32 %, medical mineral oil - 11.3 %, antioxidant additive Agidol - 0.75 %, and a water-absorbing pad fixed on an adhesive layer, made of a nonwoven fabric and impregnated with a haemostatic compound of the following proportions: sodium carboxymethyl cellulose - 0.25-0.4 mg/cm2; calcium chloride - 1.3-1.4 mg/cm2, Furacilin - 0.003-0.005 mg/cm2. The adhesive layer coats the bottom layer either continuously, or in parallel stripes.

EFFECT: provided higher haemostatic properties of the plaster and reduced injures of the patient's skin with pain hypersensitivity threshold.

2 cl, 4 dwg, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to the area of medicine. It describes a sanitary pad with a cover layer, barrier layer and a stabilizing layer located between the cover layer and the barrier layer. The dry stabilizing layer's rigidity is at least about 0.9 g/g/m2 and the rigidity loss rate in the humid state of at least about 80%.

EFFECT: sanitary pad is highly flexible and is characterized by high absorption during use.

19 cl, 1 tbl, 8 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: invention refers to manufacture of hygienic absorbent products, particularly to female panty liners. The product includes a coating layer made of a fluid-permeable material, a barrier layer made of fluid-impermeable material and an absorbent system made of a polymer with superhigh absorbability located between the coating layer and the barrier layer. The product has an absorbability value at least approximately 1.5; average density at least approximately 0.20 g/cm3 and thickness less than 2.5 mm. Or the product has an average absorbability value at least approximately 5.0 g; average density at least approximately 0.14 g/cm3 and thickness less than 2.5 mm.

EFFECT: absorbent product is draped and shows the characteristics of absorbability required for a hygienic liner.

51 cl, 6 dwg, 3 tbl, 7 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine. Described is method of manufacturing biologically absorbable bandage, which includes envelope and biologically absorbable microspheres, in form of tourniquet. Additionally bandage envelope contains pores, formed by pore-forming system, which can be activated by external way relative to wound, or form in situ within wound surface. Bandage shape makes it possible to place the bandage on wound surface in such a way that it fills wound by shape and size. Described are bandages in form of tourniquet and their application in combination with treatment by reduced pressure is shown.

EFFECT: bandage in form of tourniquet is easy adapted to size and shape of any wound surface.

25 cl, 11 dwg

FIELD: medicine.

SUBSTANCE: invention relates to technology of hygienic absorbing products, in particular, intended hygienic absorbing sanitary towels for women. Product includes covering layer from permeable for flowing media material, barrier layer, which is made from impermeable for flowing media material, and absorbing system from polymer material with high absorbing ability and placed between covering layer and barrier layer. Absorbing product has index of drapeability, which represents ratio of average density to average value of rigidity in case of modified round bend, equal, at least, nearly 2.0. Coefficient of blocking by gel polymer with super-high absorbing ability constitutes, at least, 0.25, and its coefficient of blocking by gel for five minutes constitutes, at least, nearly 0.6.

EFFECT: absorbing product is drapeable and has absorbing properties, required from hygienic sanitary towel.

23 cl, 6 dwg, 5 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: invention refers to a technology of hygienic absorbent products. The absorbent product comprises a coating layer made of a fluid-permeable material, a barrier layer made of a fluid-permeable material, and an absorbent system found between the layers and made of a polymeric material characterised by high-absorbing power (SAP). The absorbing product has a draping angle less than 80° at x=50 mm and less than 50° at x=100 mm reported by an upright drop test presented in the description.

EFFECT: higher degree of user comfort and adequate protection.

20 cl, 7 dwg, 2 tbl, 5 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of medicine, namely to bandage means, used for treatment of burns, trophic ulcers and other skin lesions, as well as to methods of their obtaining. Described is gel, representing sparsely-cross-linked chitosan and polyanionic hydrocolloid polymer, which has 2-3 linkages of copolymers per chitosan molecule, and distributed in it auxiliary substances. As polyanionic hydrocolloid, used is suspension of sucralfate or polyalginic acid particles, containing 0.01-15 wt % of stabiliser. As stabiliser used is highly molecular polyalcohols, such as polyvinyl alcohol, polyethylene glycol, as well as polyvinylpyrrolidone or silver microparticles. Auxiliary substances are introduced into gel individually or together in concentrations from 0.01 to 30% of gel dry weight. Gel is obtained by mixing chitosan with polyanionic hydrocolloid, into which preliminarily introduced were stabiliser and auxiliary substances. Bandage material represents hydrogel layer, applied on biocompatible film from water-insoluble polymer with pores with diameter D=(0.01-5.0) mcm. Covering can be on wounds during long term from 2 to 20 days and produce medicinal effect during said period.

EFFECT: bandage means can be used in treatment of trophic ulcers and various wound types, including wounds polluted with microorganisms, trophic wounds and prolonged non-healing wounds, and also be applied as allogen skin substitute in operations aimed at recovery of skin in patients with extensive burns.

16 cl, 11 ex

FIELD: medicine, fire fighting equipment.

SUBSTANCE: there are described polyolefin dispersions, foams and cellular materials and products made thereof. Also, there is disclosed a method for making a thermoplastic cellular material of a water dispersion. The water dispersion can contain thermoplastic resin, water and a stabiliser. The method can include addition to a water dispersion of at least one expanding surface-active substance to prepare a mixture, addition of an fire retardant and/or a phase-change material, foaming of the mixture to produce foam, and removal of water at least partially to prepare a cellular material.

EFFECT: cellular materials have improved fire-resisting properties with maintained basic function.

14 cl, 9 tbl, 25 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, more specifically the preparation of extensive long-term non-healing wounds to dermanaplasty requiring the use of plastic split-skin graft. The method consists of applying hemostatic dressings are applied Gemoteks on the wound for 2-3 minutes immediately after surgical treatment on the, in the first stage of wound healing process dressings are used (3-4 days) with the alternation of Atraumatic Tissue Activetex HL, Activetex HF and Activetex HVIT-complex, while on the second stage of wound healing process (2-3 days) tissues Activetex FOM and Activetex FHF are alternated. After the appearance of the boundary epithelialisation and wound cleansing free skin grafting with split-skin graft is performed in accordance with traditional techniques.

EFFECT: invention solves the problem of easier and cheaper method of treatment of extensive long-term non-healing wounds by reducing the time of preparation of the wound surface to dermanaplasty.

2 tbl

FIELD: medicine.

SUBSTANCE: there is described a transdermal therapeutic system (5) containing a substrate (1), an adhesion layer (4), a polymer layer (2) and a detached protective coating (3). The adhesion layer (4) is organopolysiloxane and is fixed on the substrate (1) by siliconisation.

EFFECT: improved bonding strength of the substrate in the transdermal therapeutic system and the polymer layer containing biologically active substances and at least one silicon bonding agent.

7 cl, 1 dwg

FIELD: medicine.

SUBSTANCE: invention relates to medical equipment, namely to absorbing products for women, such as hygienic pads, intended for everyday use pads for knickers or protecting device used in case of incontinence. Absorbing product contains liquid-permeable upper sheet and liquid-impermeable lower sheet, two longitudinal lateral edges, one transversal anterior edge, one transversal posterior edge, front part, back part, perineum part, located between back part and front part. Intermediate part is divided into front section and back section with central line and is from 7 to 12 cm long. Absorbing product also contains at least one first element detaining microorganisms or first section, which has anterior border, posterior border and two lateral borders, first element or first section being located in such way that it will be located in user's perineum when used. First element is located on upper sheet or first section is included into upper sheet, and is located in such way that anterior border of first element or first section is on posterior section of perineum region. Product detaining microorganisms with distance between transversal posterior edge and transversal anterior edge from 2 to 6 cm, and distance between longitudinal lateral edges from 3 to 5 cm can be attached to user with location in perineum. In one of the versions of implementation absorbing product forms set for prevention or reduction of microorganism migration from anal orifice zone to genitourinary zone. Set in accordance with the second version of implementation includes application of composition for prevention or reduction of microorganism migration onto absorbing product onto mark on upper sheet by means of cotton bud, brush or peg.

EFFECT: application of invention allows to reduce risk of infection by avoiding microorganisms migration.

21 cl, 10 dwg

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to surgery, and is intended for pathogenically substantiated treatment of wounds of various etiology at the first stage of wound process. Described is application in wound covering of single complex from perforated cellulose Acetobacter xylinum and biologically active ingredients, which have therapeutic effect. Into wound covering included are complex fullerene C60/Tween-80 (antioxidant), antimicrobial component, antienzymatic and haemostatic component, necrolytic component.

EFFECT: due to wet medium supplied are optimal for wound reparation conditions, and due to application of perforated bacterial cellulose covering is vapour- and air permeable.

4 cl, 2 tbl, 4 ex

Up!