Method of treating chronic cystitis
SUBSTANCE: invention refers to medicine, namely urology, is applicable for treating chronic cystitis. That is ensured by drug instillations into a bladder. In addition, the instillation is preceded by endovesical mucosal exposure to laser light of wave length 0.62 mcm. The instillation is followed by pubic exposure to laser light of wave length 0.86 mcm within a projection of the bladder. The duration of each procedure is 7 minutes; the therapeutic course is 10-12 procedures.
EFFECT: method provides higher clinical effectiveness ensured by pain pulse interruption and improved microcirculation and consequently prolonged drug staying in the bladder cavity as a result of the exposure to laser light before the instillation, and also by deeper drug penetration in bladder tissue as a result the epicutaneous exposure to laser light after the instillation.
1 dwg, 2 tbl, 2 ex
The invention relates to medicine, namely to urology.
Chronic cystitis is one of the most common diseases in women, reaching 1,000 per 100,000 population . As a rule, cystitis is an infectious disease, although up to 30% of patients may not have the growth of flora in the urine . Extensive and sometimes haphazard and uncontrolled use of antibiotics has led to increasing resistance of pathogenic microorganisms, which makes it difficult, and sometimes makes it impossible to eradication of the pathogen. The usual treatment involves the assignment or other antibiotic, herbal medicine, pathogenic drugs; in some cases instillation of medicines. However, the inflamed mucosa of the bladder or deformed due to recurrent cystitis bladder wall may not adequately respond to the impact.
Closest to the claimed is a method of treatment of tuberculosis of the bladder helium-neon laser, in which the chemotherapy mucous membrane of the bladder is irradiated with light helium-neon laser for 10-15 minutes daily; 5-12 procedures course (A.S. USSR 1392699), seeking relief of dysuria.
However, the known method is directed to treating only patients with tuberculosis, for which a specific inflammation of the special characteristics; promotes healing by own forces of the body. In patients with chronic cystitis, especially resistant to standard therapy, these reserves are often exhausted or even exhausted.
The proposed method for the treatment of chronic cystitis by instillation of drugs, characterized in that it further before instillation spend endovesical effect on the mucous radiation with a wavelength of 0.62 μm, and after instillation above the fold in place of the projection of the bladder with a wavelength of 0.86 micron, the duration of each procedure for 7 minutes, at the rate of 10-12 procedures, increases the efficiency of treatment of patients with chronic cystitis, because at the first stage, when exposed endovesical laser radiation wavelength of 0.62 μm, contributes to the interruption of pain impulses and improve microcirculation. Instillation of drugs into the thus prepared the bladder tolerated by the patient easier, as there is no spastic contractions of the detrusor and bowel emptying of the bladder, which contributes to more long-term presence of the drug in the cavity of the bladder and, accordingly, more prolonged therapeutic effect. To ensure deeper penetration of the drug into the tissue of the bladder spend cutaneous exposure laserna the radiation wavelength 0.86 micron, which, with greater depth of penetration, it appears externally.
The method is as follows. After spontaneous urination and toilet vulva, the patient is placed in the urology chair with diluted feet. The outer opening of the urethra treated with an aqueous solution of chlorhexidine and dry sterile gauze ball. The urethra instilliruut katedralen for local anesthesia; exposure time of 7 minutes. Then entering the bladder emitter in a sterile urethral catheter to a depth of 10-12 cm, fixed with adhesive tape to the inner thigh of the patient. Influence of laser radiation with a wavelength of 0.62 μm for 7 minutes, after which the emitter is removed and the bladder instilliruut drug. The catheter is removed. Then place above the fold in place of the projection of the bladder emitter of infrared laser and conducted the influence of the laser radiation with a wavelength of 0.86 micron, also for 7 minutes. During testing of the proposed method, it was found that the reduction of exposure time reduces the effectiveness of treatment, and the increase - not increase it. Thus, 7 minutes is the optimal time set empirically. The number of treatments is determined by the condition of the patient and ranges from 10 to 12.
Example 1. Patient B., 24 the em. Chronic cystitis is suffering 7 years, exacerbation of 3-5 times per year. First time in urine was determined by the growth of E. coli in diagnostically significant titer sensitive to fluoroquinolones; then developed a resistance of the pathogen. When handling complaints about frequent urination (14-16 times a day and 3-4 times a night), discomfort in the bladder, pain while it is being filled and during urination. Uroflowmetric indicators: the volume of the bladder 129 ml, maximum speed urination Qmaxand 11.6 ml/sec, average Qavean 8.4 ml/sec. Started the treatment by instillation of 1% dioksidina to 20 ml with prior exposure to the mucous radiation with a wavelength of 0.62 μm to 7 minutes daily and the final impact on cutaneous region of the bladder laser radiation with a wavelength of 0.86 micron.
Starting from the 6th of procedure the patient noted significant improvement to the 10th procedure dysuria almost completely stopped. However, given the long history of the disease, as well as the continuing feeling some discomfort when urinating, decided to extend the course to 12 sessions. Upon completion of treatment: no complaints, urination free, painless. The volume of the bladder is increased to 316 ml, Qmax- to 18.7 ml/sec, Qaveto 10.3 ml/sec. At the control examination after 6 and 9 months, no complaints, the disease had anticipated.
Example 2. Patient L., 49 years. Chronic cystitis suffers 5 years, exacerbation of 1-3 times per year. In the urine was determined by the growth of E. coli - SOME 105/ml) and Enterococcus faecalis - SOME
103/ml sensitive nitrofurans and fosfomicin and resistant to other groups of antibiotics and chemotherapeutic agents. When handling complaints about frequent urination (16-18 times a day and 3-4 times a night), pain during urination, discomfort in the bladder, pain while it is being filled and during urination, feeling of incomplete emptying of the bladder. Uroflowmetric indicators: the volume of the bladder 86 ml, maximum speed urination Qmaxonly 9.4 ml/sec, average Qaveto 6.2 ml/sec. Treated with fosfomicin and monural within 10 days, which resulted in the decrease of dysuria, stop stranguria, eradication of the pathogen, the normalization of urine. However, continued discomfort in the bladder, pain while it is being filled and during urination, feeling of incomplete emptying of the bladder, which was largely due to the involutive processes of urothelia. Started treatment with instillation of Akola to 40 ml with prior exposure to the mucous radiation with a wavelength of 0.62 μm to 7 minutes daily and the final effect is akono on the area of the bladder laser radiation with a wavelength of 0.86 micron.
Starting with the 3rd procedure, the patient noted significant improvement to the 8th procedure dysuria almost completely stopped. Given the good effect, the treatment is limited to 10 sessions. Upon completion of treatment: no complaints, urination free, painless. The volume of the bladder is increased to 424 ml, Qmax- to 21.9 ml/sec, Qaveup to 14.7 ml/sec. At the control examination after 6 and 9 months - no complaints, the disease had anticipated.
The method was tested in urogenital clinic Novosibirsk TB research Institute in 24 patients. Along with the existing criteria of treatment efficacy we used the total scale of symptoms. Patients were asked to assess the severity of one or another symptom on a 5-point scale, the scores were aggregated and analyzed when evaluating the results of therapy. The original data are presented in table 1.
|The severity of clinical manifestations of the source (abs./%), n=24|
|Symptom/score||0 no symptom||1 weak||2 Unsharp||3 moderate||4 strong||5 very strong|
|Pain during filling of the bladder||0||0||0||8/33,3%||4/16,7%||12/50,0%|
|Burning at the end of urination||0||0||0||8/33,3%||5/20,8%||11/45,8%|
|Discomfort after urination||0||0||2/8,3%||5/20,8%||12/50,0%||5/20,8%|
The average score of clinical manifestations original was 15.9 per patient. The change in the treatment process point of expression of the symptoms presented in the diagram (Fig.).
Patients also reported an improvement of the microcirculation of the mucosa of the urethra using laser dopplerflowmetry that shown in table 2.
|Dynamics of capillary blood flow (n=24)|
|Indicator LDF||Source||After the treatment|
|Amax - α (P.E.)||8,5±1,4*||14,16±1,2*|
|Amax - LF (P.E.)||of 5.05±0,4***||6,12±0,3***|
|Amax - HF1(P.E.)||to 3.73±0,3*||2,14±0,8*|
|Amax - HF2(P.E.)||1,42±0,21||1,18±0,2|
|Amax - CF1(P.E.)||1,88±0,15**||2,62±03**|
|Amax - CF2(P.E.)||0,68±0,2||0,7±0,2|
|* - the difference is significant with a probability of 95%.|
|**- the difference is significant with a probability of 99%.|
|*** - the difference is significant with a probability of 99.9%.|
|THEM - the index of microcirculation|
|σ is the standard deviation|
|Tovthe coefficient of variation|
|Amax - α is the maximum amplitude of α-waves arising from the rhythmic activity of endothelial cells|
|Amax - LF - peak amplitude of the low frequency (vasumati)|
|Amax - HF1- the maximum amplitude of respiratory and predialling oscillations (13-30 min)|
|Amax - HF2- the maximum amplitude of respiratory and predialling oscillations (31-49 min)|
|Amax - CF1- maximum amplitude (50-99 min)|
|Amax - CF2- maximum pulse amplitude of oscillation (100-180 min)|
As follows from table 2, due to the claimed method of treatment of chronic cystitis recorded a significant increase of the index of microcirculation, reflecting the improvement in the perfusion of tissues. The increase in the amplitude of cardiorenal evidenced by a decrease in spasm bringing vessels, and a decrease in the amplitude of oscillations in the respiratory range on the elimination of stagnation. Significantly increased the amplitude of the α-rhythms, which is associated with the restoration of active mechanisms of microcirculation.
None of the patient is not noted any significant adverse effects of therapy.
Thus, the claimed method of treatment of chronic cystitis by instillation of drugs, characterized in that before instillation spend endovesical effect on the mucous radiation with a wavelength of 0.62 μm, and after instillation above the fold in place of the projection of the bladder with a wavelength of 0.86 micron, the duration of each procedure for 7 minutes, in the course of 10-12 treatments are simple, available both in hospital and in the clinic, not costly, and highly effective.
1. Laurent O., Epidemiological and what aspects of urinary tract infections. Proceedings of the International Symposium "urinary tract Infections in outpatients". - M., 1999. - P.5-8.
2. Rafalski CENTURIES, Stratchounski L. C., Kogan M.I. et al. Antibacterial therapy of complicated urinary tract infections in outpatients // Urology. - 2004. No. 5. - S-31.
Method for the treatment of chronic cystitis installations drugs, characterized in that it further before instillation spend endovesical effect on the mucous radiation with a wavelength of 0.62 μm, and after instillation above the fold in place of the projection of the bladder with a wavelength of 0.86 micron, the duration of each procedure for 7 min, in the course of 10-12 treatments.
FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to new compounds of formula
, where X1, X2, Y, R1a, R1b, R2a, R2b, A1, A2, A3 and A4 have the values specified in the description, which are vanilloid receptor subtype 1 (VR1) antagonists.
EFFECT: preparing a pharmaceutical composition on the basis of the compounds of formula 1 and developing methods of managing pain, neurotic pain, allodynia, inflammation or inflammatory disease associated pain, inflammatory hyperalgesia, bladder hyperactivity and urine incontinence.
22 cl, 21 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: what is offered is applying 10-[(3R)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-10H-phenothiazine (V0162), as well as its pharmaceutically acceptable salts for preparing a drug applicable for treating or preventing urinary incontinence and related disorders caused by bacterial or mycotic infections developed due to cystic hyperactivity by means of selective inhibition of M1, M2- and M3-muscarine receptors in local and/or oral application.
EFFECT: V0162 decreases intracystic pressure, promotes anticholinergic action in vivo, effectively passes through a mucous membrane, reaching the levels involved in its anticholinergic activity, and when delivered locally has no toxic action neither histologically relation, nor with respect to the vital functions: respiratory rate, pulse, behaviour.
8 cl, 5 tbl, 5 ex
SUBSTANCE: there are offered a pharmaceutical composition for treating a overactive bladder (OAB) containing a therapeutically effective amount of a first compound (being an antimuscarinic or anticholinergic agent) and a therapeutically active amount of a second compound (causes salivary gland stimulation), and (i) the first compound is oxybutynin or its acceptable salt, and the second compound is pilocarpin or its salt; or (ii) the first compound is tolterodine or its salt, and the second compound is pilocarpin or its salt, and a relevant method of treating a patient involving introduction of the pharmaceutical composition described above. It is shown that antimuscarinic activity of oxybutynin, responsible for its therapeutic effect on OAB, remains unchanged after introduction of the composition after its adverse side effect - dry mouth - completely neutrolised.
EFFECT: invention leads to more tolerable, effective and profitable treatment.
15 cl, 7 dwg, 3 tbl
SUBSTANCE: invention relates to a compound of formula (II-A) or pharmaceutically acceptable salt thereof: [in which symbols denote the following: R10-R12: are identical or different and each denotes halogen, lower alkyl, halogen-lower alkyl, -OR0, -O-halogen-lower alkyl or -CN, R13: R0, halogen, halogen-lower alkyl, -OR0, -O-halogen-lower alkyl or -CN, ring B: benzene ring or a 5-6-member heteroaromatic ring containing 1-2 heteroatoms selected from O, S and N, R14: R0, halogen or -OR0, R0: are identical or different and each denotes H or lower alkyl, Y1: a single bond, lower alkylene, lower alkenylene or O-lower alkylene-, and Z1: -CO2R0 or -C0-NH-SO2-lower alkyl]. The invention also relates to a pharmaceutical composition based on the said compound, having antagonistic effect on the EP1 receptor.
EFFECT: obtaining novel compounds and a pharmaceutical composition based on said compounds, which can be used in a medicinal agent for treating lower urinary tract symptoms.
6 cl, 56 tbl, 231 ex
SUBSTANCE: invention refers to urology, gynaecology, physiotherapy. A method involves electrical stimulation of periurethral tissues. The electrical stimulation is ensured by a vaginal sensor. The patient is exposed to current of the frequency 12-35 Hz, pulse duration 200-400 mcS. The exposure length is 25-30 minutes. The therapeutic course is 10-15 sessions. The electrical stimulation is followed with the introduction of dextranomer/hyaluronic acid in a submucous layer of the middle one-third of urethra. In 15-20 days after the introduction of said dextranomer is followed with another electrical stimulation in said modes in number of 5-10 sessions.
EFFECT: method provides higher clinical effectiveness, prolongs the remission due to charged dextranomer particle confinement and intensifies the formation of proper collagen fibres in an introduction place.
FIELD: medicine, pharmaceutics.
SUBSTANCE: prodrugs are represented by formula or in which in formula (2) R1 represents an atom of hydrogen or C1-C6-alkyl group; X is C=O or C1-C3 slkylene group; R2 and R4 each independently represents a hydrogen, C1-C6-alkyl group; and R3 is C1-C6 alkyl group, and in formula (3) R1 has values specified in formula (2); n is an integer from 1 to 6; and R5 is a hydrogen atom or -COOR6 (where R6 is a hydrogen atom or C1-C6 alkyl group), where in formula (2) and (3) Y is a group, represented by formula (5), which is given in the invention formula.
EFFECT: obtaining novel water-soluble prodrugs, which cam be introduced parenterally, and which demonstrate high solubility in water are quickly turned into an active form.
12 cl, 7 tbl, 14 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to compound of formula: or to its pharmaceutically acceptable salt, where: Ar2 represents phenyl or pyridyl, each of which is substituted by 0-4 substituents, independently selected from R2; X and Z represent N; Y represents CRX; D represents N; F represents N, CH or carbon, substituted by substituent, representing R1 or R10; Rx in each case is independently selected from hydrogen, halogen, C1-C4alkyl, amino, cyano and mono- or di-(C1-C4alkyl)amino; R1 represents 0-3 substituents, independently selected from: (a) halogen, cyano and nitro; (b) groups of formula -Q-M-Ry; R10 represents one substituent, selected from: (a) groups of formula -Q-M-Ry; so that R10 is not hydroxy, amino or unsubstituted group, selected from C1-C6alkyl, C2-C6alkenyl, C2-C6alkinyl, C1-C6aloxy, C2-C6alkyl, ether, C2-C6alkanoyl, C3-C6alcanone, C1-C6halogenalkyl, C1-C6halogenoalkoxy, mono- or di-(C1-C6alkyl)amino, C1-C6alkylsulfonyl, mono- or di-(C1-C6alkyl)aminosulfonyl or mono- or di-(C1-C6alkyl)aminocarbonyl; each Q is independently selected from C0-C4alkylene; each M is independently absent or is selected from O, C(=O), OC(=O), C(=O)O, S(O)m, N(RZ), C(=O)N(Rz), C(=NH)N(Rz), N(Rz)C(=O), N(Rz)C(=NH), N(Rz)S(O)m, S(O)mN(Rz) and N[S(O)mRz]S(O)m, where m equals 2; and Rz in each case is independently selected from hydrogen, C1-C8alkyl and groups, which taken together with Ry, form possibly substituted (4-7)-member heterocycle; and each Ry independently represents hydrogen, C1-C8halogenalkyl, C1-C8alkyl, C2-C8alkenyl, (C3-C8carbocycle)C0-C4alkyl, ((4-7)-member heterocycle)C0-C4alkyl or taken together with Rz forms (4-7) member heterocycle, where each alkyl, carbocycle and heterocycle is substituted by 0-4 substituents, independently selected from hydroxy, halogen, amino, cyano, nitro, -COOH, aminocarbonyl, aminosulfonyl, C1-C6alkyl, C3-C7cecloalkyl, C2-C6alkyl ether, C1-C6alkanoyl, C1-C6alkylsulfonyl, C1-C8alkoxy, C1-C8hydroxyalkyl, mono- and di-(C1-C6alkyl)aminocarbonyl, mono- and di-(C1-C6alkyl)aminosulfonyl, mono- and di-(C1-C6alkyl)amino, C1-C6alkanoylamino and phenyl; so that Ry is not hydrogen, if Q represents C0alkyl and M is absent; each R2: (a) is independently selected from (1) hydroxyl, amino, cyano, halogen, -COOH, nitro and (2) C1-C6alkyl, (C3-C8cycloalkyl)C0-C4alkyl, C1-C6halogenalkyl; R3 is selected from: (1) hydrogen; (2) C1-C6alkyl and (C3-C8cycloalkyl)C0-C2alkyl; and (3) groups of formula: where L represents C0-C6alkylene; R5 and R6: (a) are independently selected from C1-C12alkyl, (C3-C8cycloalkyl)C0-C4alkyl; or (b) are combined with formation of (4-6)-member heterocycle, containing one or two heteroatoms independently selected from O and N; and where each of (2) and (3) is substituted by 0-4 substituents, independently selected from: C1-C6alkyl and (C3-C8cycloalkyl)C0-C2alkyl, each of which is substituted by 0-4 secondary substituents, independently selected from hydroxy, C1-C4alkyl and C1-C4alkoxy; and R4 represents 0-2 substituents, independently selected from C1-C3alkyl.
EFFECT: claimed are pharmaceutical compositions for modulation of capsaicin receptor activity and methods of applying said compounds for treatment of such disorders as pain, itch, cough, hiccup, urinary incontinence or obesity.
65 cl, 1 tbl, 10 ex
SUBSTANCE: invention refers to medicine, oncology, and can be used for photodynamic therapy of superficial spreaded bladder carcinoma. For this purpose, 2 hours prior to the laser esposure, the chemopreparation Mitomycin C in dosage 40 mg in 50 ml of 0.9% physiologic saline is introduced in the bladder cavity. The laser exposure follows through an intracystic optical fluid medium.
EFFECT: method allows higher clinical antineoplastic effectiveness ensured by enlarged desmosomal spaces of tumour tissues that simplify chemopreparation transport, the presence of the photosensitiser in the tumour cells promotes maximum concentration of the chemopreparation in the tumour in relation to the normal mucosa, as well as prolonged exposure of the chemopreparation on the tumour, potentiated effect of the photodynamic therapy on the tumour.
SUBSTANCE: in formula is or , is , R1 is hydrogen, halogen, nitro or amino, R2 is hydrogen or lower alkyl, R3 is hydrogen, -X- is where -Y- is a bond, -O-, -NH- or -CH2-, and R4, R5 and R6 each denotes hydrogen, R7 is (C1-C8)-alkyl, (C3-C8)-cycloalkyl, -Z-R9 or , where -Z- is -O- or -S-, and each R9 independently denotes (C1-C8)-alkyl, (C3-C8)-cycloalkyl, and R8 is -D-E-R10, in which -D- is -CONHSO2-, E is (C1-C6)-alkylene and R10 denotes -O-R11 in which R11 is hydrogen. The invention also relates to use of said compounds to prepare a medicinal agent, a pharmaceutical composition and a method of preventive and/or therapeutic treatment of overactive bladder and/or acraturesis.
EFFECT: derivatives are highly effective.
7 cl, 56 ex
SUBSTANCE: invention relates to use of a therapeutic agent which is an α-amino-amide compound of formula (I):
, in which R is a phenyl ring which is optionally substituted with one or two substitutes independently selected from halogen, hydroxy, cyano, C1-C6-alkyl, C1-C6-alkoxy or trifluoromethyl; R1 is hydrogen or C1-C6-alkyl; R2 and R3 are independently selected from hydrogen, C1-C4-alkyl; R4 and R5 independently denote hydrogen, C1-C6-alkyl; X is O or S; Y and Z, taken together with X and a phenyl ring bonded to Y and X, form a 5-7-member saturated heterocycle containing O or S atoms, or Y and Z denote hydrogen; or its isomers, mixtures and pharmaceutically acceptable salts for preparing a medicinal agent for treating lower urinary tract disorders.
EFFECT: obtaining a pharmaceutical composition based on the said compounds.
8 cl, 6 ex
SUBSTANCE: invention refers to medicine, namely therapy, and is applicable for correction of cardiovascular disorders accompanying metabolic syndrome in the patients suffering osteoarthrosis. It involves the supravenous blood exposure at wave length 405 nm, light guide tip power 1.5 mWt, length of a procedure 5 minutes. It is followed by contact joints exposure at wave length 630 nm, pulse power 10 Wt, frequency 80 Hz. Knee joints are exposed for 2 minutes from 4 sides and with using a lability technique by beam scanning along an joint space for 2 minutes. Hip joints are exposed through a projection of inguinal ligament, greater trochanter, ischial tuberosity for 2 minutes and with using a lability technique by beam scanning along the joint space for 4 minutes. The therapeutic course includes 10 daily sessions.
EFFECT: method allows providing prolonged remission and lowered drug load ensured by eliminating inflammatory activity, lipid spectrum, coagulation hemostasis and carbohydrate metabolism disorders.
SUBSTANCE: invention refers to physiotherapeutic apparatuses and is applicable for vitality recovery after damaging exercises and mental overload, and for treating various diseases by laser reflex therapy. A presented apparatus comprises a handle body which integrates a laser diode coupled with a control unit with emission brought outside through an outlet on a pointed handle tip. A side surface of the handle comprises a general electrode also connected with the control unit. The control unit is connected to a power supply unit. In the presented apparatus, the power supply unit and the control unit are integrated in the handle, on an internal side surface of the outlet, there is an acupuncture point detector represented by a thin metal core of the diameter no more than 1 mm one end of which is bent so that it gets into a laser beam, and another one is connected to the control unit.
EFFECT: invention allows detecting the acupuncture points more precisely with using a laser beam.
SUBSTANCE: claimed invention relates to ophthalmology, namely to ophthalmic oncology and is intended for organ-preserving treatment of intraocular tumours. Transpupillary PDT is performed. After 3-20 days treansscleral PDT is carried out. After tumour devitalisation, total vitrectomy and endoresection of tumour is performed. Vitreous cavity is filled with substitute of vitreous body and laser coagulation of retina is carried out.
EFFECT: method ensures radical complete destruction of tumour with extension of indications to organ-preserving treatment with recovery of functional reserves of eye.
SUBSTANCE: invention relates to animal husbandry, in particular, to methods of prevention transport stress of pigs. The method consists in activation of physiological adaptation mechanisms by daily exposure of pulsed low-intensity infrared radiation on the skin surface in the zone of localisation of the biologically active centers (BAC) № 4, №23, №33, №37, №50, №59 with frequency of 600 Hz, with a capacity of 10 mW with exposure of 256 seconds to each center, ten days prior to transportation.
EFFECT: method enables to increase the level of BAC biopotential, reduce the loss of body weight during transportation and improve meat quality obtained after slaughter carcasses.
1 dwg, 2 tbl, 2 ex
SUBSTANCE: invention refers to medicine, particularly to cardiology and laser therapy, and may be used in treating the patients with ischemic heart disease (IHD) or patients with IHD combined with diabetes. A method involves standard therapeutic treatment of the disease. Before the beginning of treatment, blood glucose and total blood cholesterol are evaluated. If blood glucose in the patients with IHD is less than 4.75 mmol/l and total blood cholesterol in the patients with IHD combined with diabetes is less than 5.5 mmol/l, laser therapy is additionally prescribed.
EFFECT: method provides proved prescription of an additional type of treatment in the form of laser therapy due to prediction of its efficacy on the basis of simple objective criteria without using expensive examination in the patients.
SUBSTANCE: invention refers to medicine, namely physiotherapy, neurology and may be used for integrated treatment of the patients with discirculatory encephalopathy. With underlying base recovery therapy, there is prescribed magnetic infrared laser therapy generated by the "MILTA-F" apparatus of wave length 0.83 mcm, magnetic induction intensity of constant magnetic field 60 mT, exposition 0.5-2 minutes on each zone. Rge patients with atherosclerotic discirculatory encephalopathy with diffuse hemodynamic insufficiency require supravenous irradiation of ulnar vascular fascicles and sinocarotid zones in all pools every second day at irradiation frequency - 5 Hz, radiating power of light-emitting diodes - 50-90 mWt. If the given pathology is combined with arterial hypertension, additionally cervical sympathetic ganglia are irradiated at frequency - 50-80 Hz, radiating power of light-emitting diodes - 50 mWt. The therapeutic course is 10-12 daily procedures. The therapeutic course is performed three times every month.
EFFECT: method enables stabilising cerebral haemodynamics, lipid profile, arterial pressure values, improving clinical neurological semiology, functional condition of vegetative nervous system, cognitive and emotional-volitional spheres.
3 tbl, 2 ex
SUBSTANCE: invention relates to medical equipment and can be used for treatment of tuberculosis, open wounds, ETN diseases and in gynecology. Multiwave laser system contains laser emitter with radiation wavelength 1.06 mcm, with pump system, power source, control system, converter of radiation into visible and ultraviolet region of spectrum on linear crystals, system of isolation of spectrum sections and fiber-optic system of laser radiation transport. Laser emitter is made in form of solid-state driving oscillator with longitudinal pump by semiconductor diode 21, which contains active element 25, made with possibility to generate radiation with σ-polarisation, and passive Q-switching.
EFFECT: application of the invention will make it possible to increase radiation output in IR, visible and ultraviolet ranges of wavelength, ensure small weight and size characteristics and high degree of safety for servicing personnel and patients, ensure stable output parameters of radiation.
4 cl, 3 dwg
SUBSTANCE: invention refers to medicine, particularly gastoenterology, reflexotherapy, physiotherapy. It involves a conventional drug-induced therapy of chronic pancreatitis. It is added with the antidepressant azaphen 75 mg daily in clinically apparent affective disorders, 50 mg daily in subclinically apparent affective disorders for 30 days. Magnetic laser puncture is performed with considering a vegetative balance state. One biologically active point is exposed to modulated wave length 1.3 mcm, frequency 2.4 Hz, magnetic induction 50 mT for 10-30 seconds. Sympathicotonia requires sequential sedation of the point GI 4 and toning of the points. E 25, E 36, MC 6. Vagotonia requires toning of the point GI 4 and sedation of the points E 25, E 36, MC 6. It is accompanied with transcutaneous magnetic laser exposure at wave length 0.89 mcm with using a magnetic tip 150 mT. A solar plexus area, a projection of pancreas, a projection of gall bladder are covered for 2 minutes. In manifested pain syndrome, the exposure starts at the frequency of 820 Hz to be decreased to 80 Hz. In weak pain syndrome, the frequency of 360 Hz is gradually decreased to 80 Hz. In the absence of pain syndrome, the exposure is applied at the frequency of 80 Hz.
EFFECT: method normalises a psychoemotional sphere, daily chronobiorhythms, vegetative balance state, reduced length of treatment, prolongs a remission period.
2 ex, 2 tbl
SUBSTANCE: invention relates to medicine, namely ophthalmology. A method involves introducing a photosensitiser (PS) in a patient's body that is followed by retinal exposure to laser light. Chlorine photosensitiser 0.4-0.5 mg/kg is intravenously injected for 10 minutes. Immediately after the PS introduction, ischemic areas and retinal neovascularisation areas are exposed to transpupillary laser light. That is ensured by laser light at wave length matched to maximum PS adsorption of optical emission. Power density makes 50-75 J/cm2.
EFFECT: method provides the absence of damaging action on the surrounding functional retinal areas, the absence of hemorrhagic complications and developing exudative retinal detachment, stabilises proliferative diabetic retinopathy and enables conducting the whole therapeutic volume for one session ensured by graduated retinal exposure to laser light that covers ischemic areas and retinal neovascularisation areas.
SUBSTANCE: invention relates to medicine, namely ophthalmology. A method involves the intravenous drop-by-drop introduction of chlorine photosensitiser (PS) 0.4-0.5 mg/kg for 10 minutes. Immediately after the PS introduction, filtration points are exposed to transpupillary laser light on the basis of fluorescent angiography values. That is ensured by laser light at wave length matched to maximum PS adsorption of optical emission. Power density of the exposure is 20-25 J/cm2.
EFFECT: method provides the absence of damaging action on the pigment epithelium and the neurosensory retina, the absence of extravasal fluorescence as shown by the FAG values, improved visual acuity ensured by gradual laser exposure on the retina within the filtration points.
2 cl, 1 ex
SUBSTANCE: invention refers to medicine, namely to surgery, and can be used for prevention of postoperative enteroparesis. For this purpose, by the end of a technical part of the surgery, a standard sanation procedure is followed by abdominal irrigation with ozonised Perftoran with the ozone concentration 5000 mcg/l. The irrigation volume is measured at 1 ml/kg of weight. Thereafter ozonised Perftoran is intravenously introduced at the same basis.
EFFECT: ensured technical simplicity, effective prevention of postoperative enteroparesis, considerable reduction of length of gastrointestinal motility recovery, antibiotic therapy and hospital stay.