Vertebrata digestive tract detoxicant
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to veterinary science. A detoxicant of polysilicic acid derivatives is specified in a group of reversed-phase sorbents.
EFFECT: using the detoxicant enables practically eliminating toxic effects accompanying animal's poisoning.
The invention relates to the detoxification of the digestive tract of vertebrates acute and chronic poisoning caused by drugs and narcotic drugs, mycotoxins, polycyclic aromatic hydrocarbons (PAHs) and persistent organic pollutants (POPS)such as organochlorine pesticides, paigaldamine dibenzodioxins, dibenzofurans, biphenyls and other dangerous toxins.
In recent years increasingly used for detoxification of the digestive tract of vertebrates (humans and animals) chelators, such as "Polisorb" - silica gel (Bulletin HLS No. 4, 2005); "Smectite" - aluminosilicate company Beaufour Ipsen Pharma, France; series products "Mycofix" - silicate, zeolite, biological additives company Biomin Holding GmbH, Austria; "Mycosorb" modified glucomannan from the walls of yeast cells company Alltech Inc., USA; "Sorbitols" - composition of silicates and components of the yeast wall company, LLC "Lallemand, RF.; "Enterosgel" (CJSC "Selma", RF, RU # 2293743, CL C08G 77/16 (2006.01), 20. 02.2007, and RU # 2293744. CL C08G 77/16 (2006.01), 20. 02.2007,).
These drugs have high hydrophilicity and, therefore, low sorption capacity with respect to hydrophobic substances with a high distribution coefficient in the Octanol-Water designated logPowor Kow/sub> (R.Collander, Acta Chimica Scandinavica (1951) 5, 774-780). While many drugs and medicines, as well as the vast majority of PAHs, POPS and mycotoxins are compounds with very high hydrophobicity, i.e., high value of distribution coefficient in the system octanol/water logPow=3-8.
More suitable sorbents in this situation seem to be hydrophobic sorbents able to hold on its surface such connections. Moreover, in contrast to various grades of activated carbons used as chelators, hydrophobic sorbents on the basis of hydrophobized silica or aluminosilicates possess both surface and volume capacity, which is vertical relative to the surface location of the hydrocarbon substituents.
Hydrophobizated derivatives of silica gel (xerogel anhydride polysilicon acid), containing on the surface covalently attached hydrocarbon residues, for more than 40 years are used as sorbents for high-performance reversed-phase liquid chromatography for the separation of substances of different nature (..Unger. Porous Silica, its properties and use as support in column liquid chromatography. Elsevier, Amsterdam, 1979, p.p.187-236). As hydrophobic substituents typically use alkyl residues with the number is the number of carbon atoms from 1 to 18 (usually C 4C8and C18or phenyl group. These sorbents surface has a high hydrophobicity, and the free silanol groups (-OH)present on the surface, shielded and/or not available for the liquid phase.
The technical result of the invention is the expansion of the range of existing chelators with materials having higher hydrophobicity, efficiency and availability of admission.
To achieve the technical result of the proposed detoxifier of the digestive tract of vertebrates based on the derivatives of polysilicon acid selected from the group reversed-phase sorbents, representing gidrofobizirovannogo matrix gel polysilicon acid containing on the surface of particles and pores silanol groups (OH)yand hydrocarbon substituents (R)zwhere:
y is the concentration of silanol groups in the structure and on the surface of the gel;
z is the concentration of the hydrocarbon substituents;
the ratio z/y takes the value from 79/21 to 1/99, respectively;
R is a hydrocarbon radical, coupled with a silicate basis through a covalent bond Si-C, Si-O-C or Si-NX-C and presents a linear or branched alkyl or alkyl fluoride residues with the number of carbon atoms from 2 to 24, containing from one to 4 isol is skilled or conjugated double bonds, or cyclic substituents with the General formula Ar(CH2)n-, in which Ar is an aromatic or alicyclic mono - or polycyclic Deputy with the number of carbon atoms from 6 to 24, with values of n from zero to six, and when the moisture content of the matrix from 0.1 to 95%.
As options R or Ar may contain one or more functional substituents: -Cl, -OH, -CN, -CO2H, -NH2, -SO3H, -NR'2, -PO3H2.
The moisture content of from 0.1 to 95% determines the degree of gidratirovannoi xerogel or hydrogel.
The proposed detoxifier silicate-based, different from the known structures of chelators, in addition to the silanol groups (OH), R is a hydrocarbon radical connected with silicate basis through a covalent bond Si-C, Si-O-C or Si-NX-C and presents a linear or branched alkyl or alkyl fluoride residues with the number of carbon atoms from 2 to 24, containing from one to 4 isolated or conjugated double bonds, or cyclic Deputy General formula Ar(CH2)n-, in which Ar is an aromatic or alicyclic mono - or polycyclic Deputy, with the number of carbon atoms from 6 to 24, with values of n from 0 to 6, as well as with functional substituents previously for the purpose of detoxification vertebrates has not been used in this capacity, not about the Isan in scientific, technical, patent literature and in medical documentation.
As a detoxifier in the present invention can also be used a known or new hydrophobizated derivatives of natural or synthetic aluminosilicates represented by the bentonites, smectites, montmorillonite, zeolites, sodium-calcium hydrated aluminosilicates, etc. with the above substituents.
The detoxifier of the present invention apply:
1) by adding a detoxifier in food in the form of a dry powder or soaked in water detoxifier in the form of a xerogel in zootechnika and veterinary medicine for fattening and/or treatment of poultry, fish, pigs, horses, small and large cattle and other domestic animals;
2) in the form of aqueous suspensions or dry gel of detoxifier, or in the form of enteric capsules, or the retina of a suitable material, filled detoxifier dry or moistened with water in medicine - per os;
3) by adding it to the feed dry powder detoxifier or moistened with water detoxifier in the form of a gel in zootechnics when feeding wild animals that are of practical interest for hunting.
To confirm the declared technical result was a comparative evaluation of the sorption capacity of a typical reversed-F. the gas chromatographic sorbents "Lichrosorb RP-8" (cat. No. 9143, Merck, Germany) with a particle size of 7 μm, specific surface area 300 m2/g and pore diameter of 10 nm, which is a silica gel with the above parameters with covalently grafted through the connection of Si-C aktalnye residues (C8)containing 9.5% of carbon, and sorbent "Enterosgel" (CJSC "Selma", Russia), containing in its composition metal of the group (C1). For evaluation used a hydrophilic dye Congo red and hydrophobic PAHs naphthalene - household insecticide poison. The evaluation was conducted according to the method described in patent RU No. 2293744, CL C08G 77/16 (2006.01), 20, 02.2007, (Congo red) and chromatographic - based methods described below (naphthalene).
According to the patent RU №229374 sorption capacity declared gel against Congo red is 4.9±0.7 µmol/g According to the measurements of the sorption capacity of hydrophobic reversed-phase sorbent Lichrosorb RP-8" was 1.75±0.15 µmol/g
To evaluate the sorption capacity of the reversed-phase sorbent Lichrosorb RP-8 and enterosorbent "Enterosgel" in relation to hydrophobic compounds was used naphthalene, representing the class of simple hydrophobic PAHs, with the value of the distribution coefficient >3 (logPow=3.3V) and a solubility in water at 30 mg/L. All work with naphthalene were carried out in glass containers. In 100 ml of purified water was placed a portion naftalina 5 mg Suspension of naphthalene portions homogenized in a hand homogenizer of downs with a capacity of 15 ml to obtain a homogeneous suspension of naphthalene in water. The suspension was filtered through a syringe equipped with a filter with a pore diameter of 0.22 μm. The concentration of naphthalene was determined using liquid chromatography according to the method of external standard in the system acetonitrile: water (65:35) octadecylphenol column with detection at 275 nm. The concentration of naphthalene in the obtained filtrate was 24 µg/ml. To remove physically adsorbed water samples sorbents, "LiChrosorb RP-8", and "Enterosgel" before the experience was placed in an oven and kept at 110°C to constant weight.
In accordance with the methodology below in three test tubes with ground stoppers were placed in 5 ml of a solution of naphthalene (accurately weighed). To a solution of naphthalene in the second and third tubes added accurate sample sorbents "LiChrosorb RP-8" and "Enterosgel". The first sample was used as control. All three tubes for 2 hours was placed into the rotating device of the planetary type speed turn 120 rpm Then the tubes were centrifuged in a basket rotor at 4000 rpm for 30 minutes. The liquid phase was analyzed for content of naphthalene. The sorption capacity reversed-phase sorbent LiChrosorb RP-8 in this experiment amounted to 55 is 2.5 µmol/g, while the concentration of naphthalene in the liquid phase of the third tube ("Enterosgel") was not significantly different from the control, i.e. unlike used reversed-phase sorbent, the medicine is not able to adsorb hydrophobic compounds of the type of PAH. These data confirm the possibility of using reversed-phase sorbents brand "LiChrosorb RP-8 for detoxification of hydrophobic toxic compounds, which include most of the PAHs, POPS.
To confirm the detoxifying properties of the sorbent LiChrosorb RP-8 in vivo was carried out the following experiment. To this end used male mice inbred lines C57B L/6J at the age of three weeks with an average weight of groups from 10 to 11, Were selected 4 groups of 10 animals each. Two experimental groups were injected typical POPS Arochlor 1254 (Supelco Inc., USA) in sunflower oil per os at a dose of 25 mg/kg for 10 days from the first to the 12th day (5 days + 2 days break + 5 days). Both the control group received only the vehicle (sunflower oil) in the same volume. The second control (No. 2) and the second experimental group (No. 4) from the first day of the experiment received pellets containing 0.075% (V/V) sorbent "LiChrosorb RP-8". The first prototype, and the first control group received conventional pellets. All animals in groups weighed every 5 days.
The results of exp is rimental to confirm the claimed technical result is shown in Fig.1 and Fig.2.
Figure 1 illustrates the impact of POPS Arochlor 1254 and reversed-phase sorbent LiChrosorb RP-8 on the body weight of male mice, where the axis is specified observation period in days on the y-axis of an average body weight of animals in grams. Curve 1 is the first control group, curve 2 - the second control group, curve 3 is the first experimental group, curve 4 is the second experimental group.
The curves in figure 1 show that the weight of the animals in both control groups were not significantly different, whereas in the experimental groups, the weight of animals differs between these groups and the values in the control, especially in 1-the first experimental group (No. 3).
It is known that Arochlor 1254 leads to an increase in the relative size of the liver, slows weight gain in growing mice, and in large repeated doses (>100 mg/kg) leads to a fall in weight, exhaustion and death of animals (Safe S. Crit. Rev. Toxicol. (1984) 13(4), 319-395). At the same time, the slowdown in the growth of the body in the second experimental group (No. 4) is much smaller than in the first experimental group (No. 3), and already by the second half of the experiment the weight of the animals in this group did not differ significantly from the control.
Figure 2 illustrates the impact of POPS Arochlor 1254 and reversed-phase sorbent LiChrosorb RP-8" on the relative weight of the liver of mice, where the abscissa axis is indicated the experimental group of animals on the y - axis relative liver weight in %. 100% take the Ali relative weight of the liver in the first control group.
The data in figure 2 show that significant differences are observed only in the first experimental group (No. 3), in which the animals did not receive enterosorbent.
Thus, it is proved that a typical reversed-phase sorbent brand "LiChrosorb RP-8 effectively Sorb hydrophobic PAHs (for example, naphthalene), and its application in the stern as a detoxifier in a concentration of 0.075% allows when used doses typical of the POPS (for example, Arochlor 1254) significantly reduce practically to eliminate the toxic effects of toxicant in the organism of experimental animals.
The detoxifier for the digestive tract of vertebrates based on the derivatives of polysilicon acid, wherein selected from the group reversed-phase sorbents.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention concerns veterinary science. A polyfunctional enterosorbent contains schungite-containing minerals comprising silicon dioxide 15.0-70.0 wt %, with an average median particle size 15.0*10-6 m.
EFFECT: invention provides higher efficacy on a wide spectrum of toxic substances, including mycotoxines, nitrates, nitrites, heavy metal salts, and also as an antibacterial and antioxidant agent.
14 tbl, 14 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to zinc-containing antidote of lethal and severe poisonings with carbon monoxide. Claimed antidote represents intramolecular tricyclic complex of triethanolamine with zinc salts of inorganic or organic acids (2, 8, 9-trihydrozincatrane) with ratio of triethanolamine to zinc salts being 1:1. Invention also relates to method of protection against poisoning by carbon monoxide by peroral introduction into organism of zinc-containing antidote in 5 vol. % ethanol in dose range 20-60 mg/kg of body weight.
EFFECT: prevention of lethal poisoning with carbon monoxide, higher efficiency and reducing acute toxicity of zinc-containing antidote.
9 cl, 5 ex.
SUBSTANCE: invention refers to medicine, namely to toxicology, and can be used for treating rats with acute verapamil intoxications. That is ensured by administering sodium thiosulphate 15-20 mg per 100 g of rat's weights as a cardioprotector.
EFFECT: method provides improved central venous pressure value.
3 ex, 1 tbl
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to zinc-containing antidote of lethal and severe poisonings with ethanol. Claimed antidote represents intramolecular tricyclic complex of triethanolamine with zinc salts of inorganic or organic acids (2, 8, 9-trihydrozincatran), the ratio of triethanolamine to zinc salts being 1:1. Invention also relates to method of treating ethanol poisoning by introduction into organism of zinc-containing antidote in 5 vol.% ethanol in dose range 30-60 mg/kg of body weight.
EFFECT: prevention of lethal outcome in case of ethanol poisoning and reduction of acute toxicity of zinc-containing antidote.
9 cl, 5 ex
SUBSTANCE: Chinese magnolia is extracted with liquefied carbon dioxide. The obtained CO2 extract undergoes chromatographic separation on aluminium oxide and eluated with hexane. After eluation the obtained hexane fractions are frozen and recrystallised from the chloroform-hexane mixture in ratio of 1:10-3:10.
EFFECT: high output of product.
FIELD: medicine; veterinary science.
SUBSTANCE: method consists in introduction to an experimental animal of Acyzol 30 mg/kg once a day combined with daily subcutaneous introduction of cadmium sulphate solution in a dose 0.1 mg/kg.
EFFECT: prevention of cadmium toxic effect in chronic poisoning in experimental animals.
2 cl, 1 tbl, 1 ex
SUBSTANCE: invention relates to medicine and pharmaceutical industry, and more specifically to making tableted dosage form with prophylactic effect for arresting primed reaction to radiation and early transient incapacity. The agent contains ondansetron, methacin and caffeine in weight ratio ondansetron:methacin:caffeine 4:1:20-300.
EFFECT: reduced adverse reaction, more specifically vomiting, diarrhea and reduction of physical activity.
5 cl, 11 tbl
SUBSTANCE: claimed is remedy possessing antitoxic properties in case of aliphatic alcohol poisoning. As such polyosm - 30% solution of polyethylene oxide 400 is suggested. It is shown that polyosm protects animals against death (100% in control) in case of isopropyl alcohol poisoning.
EFFECT: water content in lungs is analogous to index of intact animals at moderate reduction of respiration rate.
6 tbl, 9 ex
SUBSTANCE: invention refers to veterinary science, in particular to products intended to increase capacity for survival and yield of poultry. For this purpose common composition 1,3-di(3-piperidine-2-hydroxypropyl)-6-methyluracil of formula: is used. Composition is characterised by natural resistance, antioxidant activity, activates nonspecific factors of immune system, as well as possesses medicinal properties to provide detoxification of nitrates and nitrites. Composition has the appearance of white powder, is highly soluble in water and can be added in specified doses to chickenfeed.
EFFECT: production of composition providing increase of capacity for survival and yield of poultry.
6 tbl, 5 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to pharmaceutical industry and deals with acizol application as preventive and therapeutic means in neurotoxin poisoning cases. The present invention showed high efficacy of acizol in complex treatment for toxico-hypoxic encephalopathy and pneumonia (normalisation of homeostasis indices, lowering of mortality and disabling complications).
EFFECT: lowering of the risk of complications in neurotoxin poisoning cases.
SUBSTANCE: invention refers to veterinary medicine. A method consists in the fact that injured areas are repeatedly coated every 3-5 days with an ointment with high penetrating and healing effect on the basis of organosilicone glycerohydrogel of the following composition Si(C3H8O3)4·xC3H8O3·yH2O wherein 5≤x≤6; 28≤y≤30; as active substances, it contains antimicrobial preparations pefloxacin, metronidazole and chlorhexidine bigluconate in the following proportions, wt %: pefloxacin 1.0÷1.5, metronidazole 1.0÷1.5, chlorhexidine bigluconate 0.005÷0.01, organosilicone glycerohydrogel - up to 100. Treating severe hoof injures and hoof detachment also requires introducing the drug into a hoof cavity by means of a syringe to fill up the cavity.
EFFECT: method provides reducing length of treatment in animals, promotes healing of deep ulcers and adherence of the detached hoof with hoof healing and growing.
3 cl, 6 dwg, 2 tbl
SUBSTANCE: present invention is related to new quinolone derivatives of general formula (I) where R1: C3-6cycloalkyl or lower alkylene C3-6cycloalkyl, R2: -H or halogen, R3: -H, halogen, -OR0 or -O-(lower alkylene)-phenyl, R0: are the same or different from each other, and each represents -H or lower alkyl, R4: lower alkyl, halogen(lower alkyl), lower alkyleneC3-6cycloalkyl, C3-7cycloalkyl or a heterocyclic group, where cycloalkyl and the heterocyclic group specified in R4 can be respectively substituted, R5: -NO2, -CN, -L-Ra, -C(O)R0, -O-Rb, -N(R6)2, lower alkylene-N(R6)(Rc), -N(R6)C(O)-Rd, lower alkylene-N(R6)C(O)-Rd, lower alkylene-N(R0)C(O)O-(lower alkyl), -N(R0)C(O)N(R0)-Re, lower alkylene-N(R0)C(O)N(R0)-Re, -N(R0)S(O)2N(R0)C(O)-Rd, -CH=NOH, C3-6cycloalkyl, (2,4-dioxo-1,3-thiazolidin-5-yliden)methyl or (4-oxo-2-tioxo-1,3-thiazolidin-5-yliden)methyl where cycloalkyl specified in R5 can be respectively substituted, R6: H, lower alkyl, lower alkylene-CO2R0 or lower alkylene-P(O)((OPp)2, where lower alkylene specified in R6 can be substituted, L: lower alkylene or lower alkenylene which can be respectively substituted, Ra: -OR0, -O-(lower alkylene)-phenyl, -O-(lower alkylene)-CO2R0, -CO2R0, -C(O)NHOH, -C(O)N(R6)2, -C(O)N(R0)-S(O)2-(lower alkyl), -C(O)N(R0)-S(O)2-phenyl, -C(O)N(R0)-S(O)2-(heterocyclic group), -NH2OH, -OC(O)R0, -OC(O)-(halogen(lower alkyl)), -P(O)(ORp)2, phenyl or the heterocyclic group where phenyl or the heterocyclic group specified in Ra can be substituted, Rp: R0, lower alkylene-OC(O)-(lower alkyl), lower alkylene-OC(O)-C3-6cycloalkyl, lower alkylene-OC(O)O-(lower alkyl), Rb: H, lower alkylene-Rba or lower alkenylene-Rba where lower alkylene or lower alkenylene specified in Rb can be substituted, Rba: -OR0, -CO2R0, -C(O)N(R0)2, -C(O)N(R0)-S(O)2-(lower alkyl), -C(O)N(R0)-S(O)2-[phenyl, -C(NH2)-NOH, -C(NH2)=NO-C(O)-(lower alkylene)-C(O)R0, -CO2-(lower alkylene)-phenyl, -P(O)(ORp)2, -C(O)R0, -C(O)-phenyl, C3-6cycloalkyl, phenyl or the heterocyclic group where phenyl and the heterocyclic group specified in Rba can be substituted, Rc: H, lower alkylene-OR0, lower alkylene-CO2R0, lower alkylene-P(O)((OPp)2, phenyl where lower alkylene and phenyl are specified in Rd can be substituted, Rd: C1-7-alkyl, lower alkenyl, halogen(lower alkyl), lower alkylene-Rda, lower alkylenylene-Rda, C3-6cycloalkyl, phenyl, naphthyl or the heterocyclic group, where lower alkylene, cycloalkyl, phenyl, naphthyl and the heterocyclic group specified in Rd can be substituted, Rda: -CN, -OR0, -O-(lower alkylene)-CO2R0, -O-naphthyl, -CO2R0, -CO2-(lower alkylene)-N(R0)2, -P(O)(ORp)2, -N(R6)2, -C(O)N(R0)-phenyl, -C(O)N(R0)-(lower alkylene which can be used by -CO2R0)-phenyl, -N(R0)C(O)-phenyl, -N(R0)C(O)-OR0, -N(R0)C(O)-O-(lower alkylene)-phenyl, -N(R0)S(O)2-phenyl, C3-6cycloalkyl, phenyl, naphthyl or the heterocyclic group, where phenyl, naphthyl and heterocyclic group specified in Ra can be substituted, Re: lower alkylene-CO2R0, phenyl, -S(O)2-phenyl or -S(O)2-(heterocyclic group), where phenyl and the heterocyclic group specified in Re can be substituted, X: CH, A: C(R7), R7: -H, or R4 and R7 together can form lower alkylene, where the substituted groups have the substituted specified in cl.1, and provided 7-(cyclohexylamino)-1-ethyl-6-fluor-4-oxo-1,4-dohydroquinoline-3-carbonitryl is excluded. Also, the invention refers to a pharmaceutical composition based on a compound of formula (I) and application of formula (I) for preparing a thrombocyte aggregation inhibitor or a P2Y12 inhibitor.
EFFECT: there are produced new quinol-4-one derivatives showing effective biological properties.
11 cl, 83 tbl, 71 ex
SUBSTANCE: invention relates to medicine, namely, to surgery, and can be applied for treatment of purulent wounds of various etiology. For this purpose on surface of purulent wound applied is membrane capsule, filled with sorbent. As membrane capsule used is membrane bandage, which consists of polypropylene capsule, which hermetically fixed on it film. Cavity of polypropylene capsule is connected with membrane film, made from polyhydroxyalkanoate with pore size 2.7-3.0 nm, and is filled with dialysing solution, which consists of mixture of 100 ml Octenisept and 6 grams of enterosorbent Polysorb MP. Replacement of dialysing solution in membrane bandage is carried out in postoperative period daily during 10-12 days.
EFFECT: method makes it possible to increase efficiency of treatment of purulent wounds due to prevention of injury of formed granulating tissue and secondary infection.
2 cl, 3 tbl, 1 ex
SUBSTANCE: invention belongs to medicine, notably to oncology, and can be used in prevention and treatment of enteropathy due to intensive cytostatic polychemotherapy. To achieve this Enterosgel (Methylsiliconic acid hydrogel) is administered during whole course of polychemotherapy and after it. After cytostatic treatment during Enterosgel administration additionally nonabsorbable enteral antiseptic ersefuril is administered. normobiotics - Hylac-forte and Primadophilus™ Bifidus are administered when level of leukocytes in blood gets higher then 1000/mcl.
EFFECT: method ensures prevention of necrotic processes, reparation of gastro-intestinal mucous lining and fast arresting of enteropathy due to toxic metabolites enterosorption, elimination of pathogenic and opportunistic microbes and regulation of intestinal flora balance.
FIELD: medicine, veterinary science.
SUBSTANCE: invention relates to the field of veterinary science, in particular to methods and agents for treatment of obstetric-gynaecological diseases in cows. Agent contains pefloxacin, metronidazole and chlorhexidine bigluconate, and the base is represented - water-soluble organosilicic derivative of glycerin, having transmucosal activity, composition of which complies with the formula (CH3)2Si(C3H7O3)2·C3H8O3, at the following ratio of components in the agent, wt %: pefloxacin 0.75-1.0; metronidazole 1.0-1.5; chlorhexidine bigluconate 0.05-0.1; water-soluble organosilicic compound - glycerin derivative - up to 100. According to proposed method, introduction of specified agent is carried out in process of complex therapy intrauterinely 3-5 times, with interval of 48 hours, in amount of 50-100 g per single introduction with the help of Janet's syringe and polystyrene pipette for artificial insemination, at the same time prior to introduction the agent is dissolved with sterile distilled water in the ratio of 1:1.
EFFECT: increased efficiency of endometritis treatment in cows.
2 cl, 8 tbl
SUBSTANCE: invention refers to medicine, namely to surgery and endocrinology, and can be used in the patients requiring a conservative treatment of acute pancreatitis. That is ensured by a standard medical therapy by the introduction of infusion preparations, anaesthetics, spasmolytics, vasoconstrictors, antibiotics, novocaine, cytostatics, omeprazole, sandostatin. For the period of treatment, hunger with voluminous drinking is prescribed. Pit of the stomach is cooled. In addition, procaine blocks in the round ligament of liver are applied that implements the introduction of at least 200 mg of Immunomax and 10 ml of 5-fluorouracil. During 2 days, at least 1.0 g of metronidazole, 0.1 g of furaginum, at least 15.0 g of Enterosgel are intaken. During the whole therapeutic course, at least 1 ml of Sporobacterine suspension together with cooled water is taken once a day. Starting from the sixth day and during the whole therapeutic course of hospital treatment, 1 tablet of Mezym forte 2 times a day is prescribed. For at least two weeks after discharge from the hospital, treatment in a locally available health resort is continued.
EFFECT: method allows reducing considerably the probability of acute pancreatitis transition into a destructive form due to the effect of specified therapy by various pathogenesis links of specified disease.
SUBSTANCE: inventions relate to medicine, namely to oncology, and deals with treatment of liver cancer. For this purpose 4-[3,5-bis(trimethylsilyl)benzamido]benzoic acid or its physiologically acceptable salt in dose from 10 to 30 mg per day is introduced. Treatment is carried out in accordance with therapeutic regimen, in accordance to which continuous daily introduction for from 1 to 4 weeks is performed. After that period of medication withdrawal for from 1 to 3 weeks follows.
EFFECT: inventions ensure essential reduction of side effects, such as deep vein thrombosis, and in addition considerably improve therapeutic effect of TAC-101 in treatment of liver cancer.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to methods and compositions wherein low concentration of zinc salts combinations and antimicrobial agents are used for medical device coating.
EFFECT: coatings exhibit counterirritant effect and inhibit vectors of an infectious disease.
18 cl, 4 tbl
SUBSTANCE: water-soluble organosilicon derivatives of polyols are proposed, composition of which has formula (CH3)4-nSi(O-R-OH)n·x HO-R-OH in excess polyol, where R=-CH2-CH(OH)-CH2-, -CH2CH(CH3)-, (-CH2-CH2-O-)mCH2-CH2-, 0.5≤x≤2.9, n=2-4, m=7.7 or 12.0, with dynamic viscosity of 0.8-29.0 Pa·s (20±0.5°C), obtained by reacting (methyl)ethoxysilanes with polyols in molar ratio 1:(2.2-6.9) while heating the reaction mass to 120-130°C, maintaining this temperature for not less than 4 hours while stirring intensely with subsequent removal of the formed alcohol. Synthesis can take place in the presence of a catalyst, for example tetrabutoxy titanium - in amount of 0.04-0.06 mol per mole of (methyl)ethoxysilane. Also proposed a hydrogels based on said organosilicon derivatives of polyols, containing water and a gel-forming additive, with the following ratio of components in wt %: organosilicon derivatives of polyols in excess polyol 44.95 - 98.01; gel-forming additive 0.01-0.50; water - the rest. Proposed water-soluble organosilicon derivatives of polyols and hydrogels based on the said derivatives are physiologically active compounds, exhibit transcutaneous and vulnerary activity, have considerable effect on morphofunctional state of the skin and can be recommended as independent agents and as ointment bases of various pharmaceutical compositions with vulnerary activity.
EFFECT: obtaining novel water-soluble biologically active organosilicon derivatives of polyols which can be used as independent agents with transcutaneous and vulnerary activity and as bases of pharmaceutical compositions for local application.
3 cl, 2 dwg, 2 tbl, 16 ex
SUBSTANCE: present invention concerns therapeutic compositions for treating skin diseases, such as wounds, abrasions, ulcers, burns, infections, irritations, microbial, mud and water exposures, psoriasis, acne, scars, age spots, sclerosis and other physical or chemical damages, which contain cationic organosilane quaternary ammonium compounds and hydrogen peroxide in the aqueous medium.
EFFECT: invention also concerns the methods of therapeutic purification and skin treatment with said compositions.
35 cl, 5 tbl, 4 ex
FIELD: veterinary science.
SUBSTANCE: on should apply 1-(ethoxy)sylatrane as a stimulating agent for reproductive capacity in female furred animals and viability of their offspring. The innovation enables to improve reproductive function in females and viability of whelps.
EFFECT: higher efficiency.
3 ex, 3 tbl