Method and device for dispensing powder specimens


G01N1/20 - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (separating components of materials in general B01D, B01J, B03, B07; apparatus fully provided for in a single other subclass, see the relevant subclass, e.g. B01L; measuring or testing processes other than immunoassay, involving enzymes or micro-organisms C12M, C12Q; investigation of foundation soil in situE02D0001000000; monitoring or diagnostic devices for exhaust-gas treatment apparatus F01N0011000000; sensing humidity changes for compensating measurements of other variables or for compensating readings of instruments for variations in humidity, seeG01D; or the relevant subclass for the variable measuredtesting or determining the properties of structures G01M; measuring or investigating electric or magnetic properties of materials G01R; systems in general for determining distance, velocity or presence by use of propagation effects, e.g. Doppler effect, propagation time, of reflected or reradiated radio waves, analogous arrangements using other waves G01S; determining sensitivity, graininess, or density of photographic materials G03C0005020000; testing component parts of nuclear reactors G21C0017000000)
G01N1/18 - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (separating components of materials in general B01D, B01J, B03, B07; apparatus fully provided for in a single other subclass, see the relevant subclass, e.g. B01L; measuring or testing processes other than immunoassay, involving enzymes or micro-organisms C12M, C12Q; investigation of foundation soil in situE02D0001000000; monitoring or diagnostic devices for exhaust-gas treatment apparatus F01N0011000000; sensing humidity changes for compensating measurements of other variables or for compensating readings of instruments for variations in humidity, seeG01D; or the relevant subclass for the variable measuredtesting or determining the properties of structures G01M; measuring or investigating electric or magnetic properties of materials G01R; systems in general for determining distance, velocity or presence by use of propagation effects, e.g. Doppler effect, propagation time, of reflected or reradiated radio waves, analogous arrangements using other waves G01S; determining sensitivity, graininess, or density of photographic materials G03C0005020000; testing component parts of nuclear reactors G21C0017000000)
B65B1/08 - MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING (bundling and pressing devices for cigars A24C0001440000; paper-bag holders as shop or office accessories A47F0013080000; apparatus for coating, e.g. by dipping, B05C; devices for tensioning and securing binders adapted to be supported by the article or articles to be bound B25B; nailing or stapling devices B25C, B27F; inserting documents in envelopes and closing the latter B43M0003000000, B43M0005000000; labelling B65C; wrappers, containers or other packaging elements, e.g. binders, closures, protective caps, B65D; transport or storage devices B65G; devices for handling sheets or webs of interest apart from their application in packaging machines B65H; applying closure members to bottles, jars or similar containers B67B; hand- or power-operated devices not attached to, or not incorporated in, containers or container closures for opening closed containers B67B0007000000; packaging of matches C06F; wrapping sugar during manufacture C13B0045020000; packaging of ammunition or explosive charges F42B0039000000; making containers or receptacles, see the appropriate subclasses);

FIELD: process engineering.

SUBSTANCE: proposed method uses, at least, two powder specimen holders with through channel having first opening for powder to be introduced therein and second opening for powder to be discharged therefrom. Powder specimen are fed into appropriate holders to align holder second opening with appropriate opening of specimen receiver. Note here that powder flows simultaneously through second openings in mixing powders to facilitate their flow from channels into appropriate receivers. Additionally, proposed method comprises pulling elastic film on every hole and locking it relative to appropriate holder to seal its second hole as well as film perforation to seal every second opening during powder flow through second openings.

EFFECT: higher accuracy of dispensing.

22 cl, 7 dwg

 

The technical FIELD

The invention relates to methods and apparatus for dispensing powder samples for use in the preparation and analysis of materials and, in particular, the characterization of existing materials and identify new materials.

PRIOR art

Methods and devices for dispensing fluid samples described in the following documents, relevant prior art: WO 99/19215 A, US 1488603 And US 5651401 And US 3788370 And US 4895706 A, US 2002/137199 A1, US 3223490 A, US 4905525 A and US 3306323 A.

Characterization of materials for improving or optimizing the composition or the identification of new and useful compositions typically requires the execution and registration of the results of a large number of experiments. Preparation of samples for these experiments is time-consuming, and because of the poor execution by the employee (due to fatigue, boredom, etc. when performing repetitive operations) can cause error in the measurement of quantities of ingredients and/or registration of volumes, masses, and other data associated with the training. The nature of these ingredients, such as low viscosity fluids, liquids with medium and high viscosity, thixotropic liquids, powders and the like, because of the difficulty of their exact dosing may aggravate such caused by human error or calling the th other potential errors during dispensing of these ingredients.

It is often particularly difficult for accurate and repeatable metering of powders, especially when they are dispersed in small quantities and in parallel. Some of the difficulties that may occur, are initiating the flow of powder from the sample holder, minimizing the retention of powder in the sample holder and, when dispensing a variety of patterns, initiating dispensing of samples at the same time. Simultaneous multiple dosing of powders in a fluid environment may be especially important to ensure that the background samples are both identical and practically achievable. In addition, the dosing of powders in fluids, especially liquids, should ensure the direct contact of the powder with a fluid medium. For many powders, such as starches and hydrocolloids, and bulk contact with the liquid tends to aglomerirovanie in clumps greater part of the material not wetted by the liquid. Therefore, it is often necessary to add powders to fluctuating environments gradually.

The INVENTION

The present invention is to provide new methods and apparatus for dispensing powder samples. In particular, an additional objective of the present invention is to provide new methods and devices for parallel to the financing of the sample powder, when one or more of the above disadvantages are reduced or disappear.

According to the first aspect of the present invention, a method of parallel dispensing powder samples includes:

a) providing at least two sample holders powder, each of which has a through channel with a first opening through which the powder is introduced into the channel, and a second opening through which the powder, providing this capability derives from channel

b) introducing a sample of the powder in the respective sample holders;

c) combining the second hole of each bracket with the hole corresponding receiver samples; and

d) providing essentially simultaneous flow of powder through the second hole when mixing the powder samples in the channels to facilitate their promotion of the channels in the corresponding receivers

characterized in that the method further includes stretching the elastic film on each of the holes and the fixing film relative to the corresponding sample holder for sealing the second hole and, at the stage d), the perforation of the film, sealing each of the second holes.

Preferably the method includes the use of sample holders, which basically narrowed from the first hole to the second hole.

Preferably the method includes sealing the second hole of the specimen holder to the introduction of a sample powder.

Preferably the method includes, in stage d), the speed control dispensing of samples of the powder passing through the second hole.

Preferably the method includes, after the sample powder mainly flow through the second holes, the initiation of the forced gas flow through the first hole in each of the sample holders to blow off any remaining powder through the second hole.

Preferably the method includes, during stage d), the direction of the forced gas flows out from the second hole, resulting in adhesion of the powder to the outer surfaces of the specimen holder near the second hole is reduced.

According to the second aspect of the present invention, a device for parallel dispensing powder samples is equipped with at least two sample holders for keeping powder samples, with each sample holder has a through channel with a first opening through which the sample powder is introduced into the channel, and a second opening through which the sample powder is derived from a channel, the corresponding device flow control to regulate the flow of powder passing through each of the second is twisty, and a mixing device for mixing the sample powder in each sample holder during use of the device, and the specified device is characterized in that the device flow control for sample holder includes an elastic film, sealing the second hole.

Preferably, each end-to-end channel of each sample holder in a generally tapers from the first hole to the second hole.

Preferably use more than two, usually more than eight or twenty-four, the sample holders. The specimen holder can be made of one piece with another component, for example, a panel with grooves having a conical end-to-end channels. Alternatively, and more preferably, if the sample holders can be a separate holders that can be placed in end-to-end channels in the panel with grooves. Preferably, the specimen holder can be fixed in the through channels in the panel with grooves to ensure that they accurately fixed.

Wall of each sample holder, bounding through the channel, determines the space that has the shape of a truncated cone. If each sample holder is a separate holder, preferably, if at least h is here its outer wall has an essentially cylindrical configuration, so that the holder fits tightly into a corresponding through-channel in the panel with grooves. Preferably the lower portion of each sample holder has an external configuration which is essentially parallel to the inner shape of the wall sample holder, bounding through the channel.

As indicated above, the device controlling the flow profile includes film, for example, an elastic film made of latex or similar material, which are attached with clamps to each sample holder, in order to close the second hole. For punching each film you can apply separate drills for essentially simultaneous opening of corresponding openings for advancement through them powder. Alternatively, and more preferably, if the mixing device connect with each sample holder, as described in more detail below, each mixing device can be moved in parallel in the axial direction through a corresponding channel of each sample holder and punch each film to open their respective holes for the flow of powder.

According to one variant embodiment of the invention, the mixing device may include a means for physical vibration of the specimen holder and contained powder is and during application. Alternatively, the mixing device may include an ultrasonic generator for vibration of the specimen holder and contained powder during application.

More preferably, each mixing device includes a mechanism for mixing, and the mechanisms for mixing can be mutually moved in parallel relative to the specimen holder when the sample holders are located in positions dosing. Preferably the mechanisms for mixing mounted on a common supporting element, the reciprocating movement of which relative to the dispensing position of the specimen holder causes reciprocating motion mechanisms for mixing relative to the specimen holder. The movement mechanisms for mixing in the direction of the holders of a sample allows you to insert each mechanism for mixing essentially coaxially in respective channels of the specimen holder through the first hole and, in the case of sealing their second holes through the application profile films, fully perforated film through the second opening.

Each mechanism for mixing may have blades, rigid or flexible, brush, wire or similar objects, mounted rotatably around the axis, to the which, using essentially coincides with the axis of the channel in the respective sample holders. Preferably each mechanism for mixing includes a flexible part, which, when rotating around the axis, in contact with the wall of the channel of the respective sample holder and clean off with him to powder.

According to a preferred variant of the invention, the mechanism for mixing has at least one spring wire, more preferably, two spring wire mounted on its distal end and passing through the axis direction from the distal end, and located essentially in the plane that includes the axis around which the rotation takes place. Preferably, each wire has a loose position in which the free end of the wire is located at a radius from the axis that is greater than the radius of the first opening of the channel of the respective sample holder. When applying, each wire is held in a tensioned position in which the free end of the wire is located at a radius from the axis which is less than the radius of the first opening of the channel sample holder, allowing the wire can be moved along the axis relative to the sample holder and inserted into its channel. As soon as the wire enters the channel sample holder, the wire is removed the limiter,which allows the wire to move radially outward toward its unstrained position and in contact with the wall of the channel.

The wire can be held by any suitable mechanism. For example, each mechanism for mixing may have a sleeve mounted for reciprocating movement along the axis relative to the wires that gives you the ability to hook the wire and make them move inside radius in the direction of the corresponding axis or disconnected from the wires and allow them to return to their unstrained position. Preferably the ends of the sleeves in contact with the wires, with each sleeve has an internal beveled annular surface which wire hooks.

According to a preferred variant embodiment of the invention, the guide mechanism consists of a pair of parallel plates, each plate has a series of holes, preferably in a generally diamond shape, corresponding to the number of mechanisms for mixing, and the plates are placed on mechanisms for mixing so that their planes are at right angles to the axes of the mechanisms for mixing and, when the holes of the plates combined with each other, the centers of holes are arranged essentially coaxially aligned with the corresponding axes of the mechanisms for mixing. Plates can move relative to each other between a first position in which the hole is developing in the plates are aligned with each other and in which the wire of the mechanisms for mixing are unstrained position, and a second position in which the holes in the plates only partially overlapped with each other and in which the wire of the mechanism for mixing keep them in a tense position. Preferably both plates are moved symmetrically with respect to the axes of mechanisms for mixing. The plate can be moved using any suitable device, such as a pneumatic drives. Preferably the plates are in their first position, also can move along the axis of mechanisms for mixing to a position remote from their distal ends.

Preferably the speed of rotation of mechanisms for mixing and vertical reciprocating movement of the mechanisms for mixing relative to the location of the sample holders are controllable, which allows you to adjust the speed of dispensing powder samples of the sample holders.

Also preferably, the dimensions of the second openings of each sample holder is selected depending on the mass of the samples of the powder. Therefore, the small mass of the sample powder will correspond to the small diameter of the second hole and Vice versa.

Mechanisms for mixing rotated by any suitable drive mechanism, for example, motor and system with a belt drive or motor and gear or to whom Binali motor, gears and systems with belt drive. Preferably the drive mechanism installed on a regular anchor element for mechanisms for mixing.

Preferably the usual supporting element is mounted on a robotic system XYZ for automatic movement relative to the working station, which, when used, place the specimen holder or a panel with grooves equipped with sample holders. Similarly, it is preferable that the plate bounding mechanism was mounted on an XYZ robotic device for axial movement relative to the mechanisms for mixing.

Preferably, the workstation is also equipped panel for receiver samples with grooves. Although the panel for receiver samples with grooves can be placed receivers of samples produced with the panel as a whole, it is preferable that the panel had cavities, into which insert receivers for samples, such as test tubes, vials or similar, usually tubular components having an aperture or open end through which the powder or other components, solid, liquid or gaseous, can be introduced. When used during dispensing them in powder, preferably, if the open ends of the tubes are sealed and connected by derjatelyami sample or with the lower surface of the panel with grooves, on which the specimen holder, the open ends of the tubes coincide with the second holes of the respective sample holders.

A panel with grooves for the sample holders, or, alternatively, a separate panel is inserted, in use, between a panel with grooves for holders of samples and test tubes can have inlet and outlet openings for gas, which communicate with the space formed by the tube and the panel with grooves for the specimen holder or a separate panel, thereby the gas flowing in the specified space from the inlet holes or through channels in the respective sample holders can be removed from the specified namespace.

The inlet can be applied to areas of gas, usually air, to the lower ends of the specimen holder to prevent sticking of powder to the ends of the specimen holder, especially when there is a possibility of condensation of steam from the heated liquid contained in the tubes at the lower ends.

In devices in which the powder samples need to contact with the gas ingredients, you can use the intake and ventilation openings to ensure flushing of the area indicated gaseous ingredients, and then closing that ensures the filling specified what about the space of gaseous ingredient.

Thus, the device according to the invention may include Gazovye device for gas flow to the outer bottom wall of each sample holder and/or the gas a device for removing gas from the outer bottom wall of each sample holder.

According to a preferred variant of the invention, there are means to ensure receipt of forced gas, usually air, flow in the specimen holder through the first holes at the ends of the dispersant powders for washing off after their second openings of the powder remaining on the walls of the channels of sample holders. Preferably the gas flow is removed through the flue openings described above. Typically, the gas flows can provide at least one pipeline, equipped with nozzles for directing the gas flow in each first hole of the specimen holder. Each nozzle can be equipped with a device flow control, for example a pneumatic speed limiter, to regulate the flow of air into the holes of the respective sample holders.

Preferably the panel with grooves for receivers of the samples can be cooled or heated, for example, typically in the range from 5°C to 100°C, although this range may vary according to the specific device.

Samples of the powder can be dosed in tubes that do not contain other ingredients; alternatively, the tubes can contain other solid, liquid or gaseous ingredients. The method and apparatus proposed in the invention, are particularly useful for dispensing powder into a test tube containing liquid. According to a preferred variant of the invention, the fluid in the tubes shaken during dispensing them in powder. Shake liquids in test tubes can be accomplished in any suitable way. For example, in some devices, it is possible invasive or contact the shaking of liquids in test tubes, in which you can apply the usual methods using magnetic stirrers magnetic "flea", which is placed in each tube. However, non-invasive or contactless shaking of liquids is preferred. According to this variant embodiment of the invention, a panel with grooves for receivers set of samples, for example, on a device that is able to move its oscillatory manner that causes shaking of liquids in test tubes.

Samples of the powder can be introduced into the holder (holders) of the sample by any suitable means, including manually or automatically, using the device for supplying doses of powder, t is something like Powdemium, supplied by the company Autodose S.., equipment which is capable of feeding a certain mass of powder in the holder (holders) of the sample.

XYZ robotic system can be used to move the holder (holders) of the samples between the feeder dose of powder and spot metering. Holder (holders) of the sample can be pre-mounted to a panel with grooves for receivers samples.

Preferably robotic system considered device and automatic feeding device of a dose of powder regulate computer means. Preferably, the computer means provided with software that includes libraries ingredients and libraries compositions of the samples. Computer means supply doses of powder in the sample holders and the regulation of the cooling/heating/shaking of liquids in test tubes in accordance with the desired composition of the samples.

The present invention also includes the creation of libraries of sample powder by sample preparation powder and dispensing of samples in the sample holders and temporary sealing of sample holders for the persistence of the samples and prevent their contamination. The invention also offered samples of a powder comprising at least two sample holders containing formation is subjected to powder, when the specimen holder is temporarily sealed.

It is obvious that the method and apparatus proposed in the present invention, can be used to obtain samples for various chemical systems. For example, the application may be dissolved pharmaceutically active substances; adding a catalyst in the reaction system; preparation of food and drinks in those cases that require controlled dissolution, for example chocolate for making beverages; and applying the adhesive and construction coatings, in those cases when the powder ingredients should be prepared composition.

One specific application for which the invention is particularly suitable, is a study of starch and hydrocolloids, which is necessary to prepare samples of starches and hydrocolloids in the water so to have the opportunity to explore their gelation, viscosity, color, opacity and other properties. Preparation of starch and hydrocolloid solutions usually require the addition of starch or hydrocolloid to water under stirring to ensure proper dispersion of starch or hydrocolloid. Adding water to the powder starch or hydrocolloid usually do not achieve good dispersion, because the powders have with londoste to Kotkovets with the formation of agglomerates. In addition, when comparing a large number of starches, hydrocolloids and mixtures of starches and hydrocolloids, preferably, the prehistory of experimental research designs were so uniform as is reasonably practicable.

By applying the method and device according to the invention, samples of the powder, including the number of starches, emulsifiers, sealants, sugars and various types of flour in the range from 2 mg to 1000 mg were successfully distributed to the tubes, often at a residual level of the powder is less than 5%, in particular less than 3%, from a given mass of powder remaining in the sample holders.

A BRIEF DESCRIPTION of GRAPHIC MATERIALS

The invention will be illustrated with reference to the accompanying drawings, in which:

Figure 1 is a schematic horizontal projection device according to the invention;

Figure 2 is a more detailed schematic illustration of the lateral projection of the unit

Figure 3 is a diagram of two plates with holes, used for holding wires of mechanisms for mixing, shown in figures 1 and 2, with the two plates shown when combined with each other on the right side of the figure and without overlapping with each other on the left side of the figure;

Figure 4 represents the Wallpaper schematic illustration of the lateral projection of the specimen holder, mounted with a latex film for sealing the second hole holders;

Figure 5 is a schematic illustration of the lateral projection showing the specimen holder of figure 4, mounted together with receivers samples,

6 is a schematic illustration of a vertical cross section through the sample holder in accordance with the invention, and

7 is a schematic horizontal projection system supply air stream.

INFORMATION. CONFIRMING the POSSIBILITY of carrying out the INVENTION

Refer to the drawings, which shows a device for dispensing powder 10. The device 10 is described in terms of simultaneous processing of eight samples. However, it is obvious that, if necessary, by using the device can handle fewer samples or the other, higher, number of samples, for example twenty-four.

The device 10 has a housing 12, is installed on the support plate 14 automatic XYZ system 16, for example, supplied by Tecan Limited.

Epicycle device for shaking 20 is installed on the housing 12 below the support plate 14 on vibration-damping supports 18. Standard cooling/heating installation 22 is installed on the upper part of the device for shaking 20, to which the Oh is hosted panel 24 with grooves for receivers samples for holding eight receivers samples in the form of tubes 26. Cooling/heating installation 22 installation equipped rods 27 to position the panel 28 with grooves for the specimen holder relative to the installation, allowing the specimen holder 30 mounted on the panel 28 with grooves, essentially located in the centre of the tubes 26 (panel 28 with the recesses and the specimen holder 30 shown in figure 2 is only representative, but more detail is shown in Fig.4-6). The panel 28 with grooves for the specimen holder has eight through channels, which are a separate sample holders 30. End-to-end channels are cylindrical in shape and intersected by canals with thread, which is screwed into the locking screws 32, so the sample holders 30 can confidently hold relative to panel 24 with grooves.

Each sample holder 30 is essentially hollow (in particular, see Fig.6) and has an upper essentially cylindrical outer wall 34, which is sealed to the corresponding end-to-end channel in the panel 28 with the recesses, and the lower part of the wall 35, which is essentially parallel to the inner wall of the sample holder 30. The inner wall of each of the sample holders 30 sets the boundaries through channel 36, the volume of space bounded by a wall, essentially has the shape of a truncated cone narrowing of the nab, which is aulino from the top to the base of the sample holder 30. The sample powder (not shown) can be placed in), sample holder 30 through the first upper hole 40 and the metering tube through the second, lower opening 42.

Move powder through channel 36 through the second hole 42 sample holder 30 regulate with the help of the device flow control. The device flow control may be a valve mechanism (not shown) or, for example, profile film. Profile film may be a metal foil, fixed relative to the second hole 42, for example, by means of clamping plates with holes (not shown). According to a preferred variant of the invention, profile film is a flexible film, such as a latex film, such as Theraband™, supplied by Physiomed, which is fixed relative to the second hole 42.

Preferably the latex film 44 is fixed relative to the specimen holder 30, clamping it between the panel 28 with grooves for the specimen holder and the bottom plate with holes 46 (see figure 4). This procedure can be done if you put the latex film 44 when stretching along its perimeter by means of clamps 48 mounted on the housing 50 for vertical movement, lower the clamp 48 for further stretching of the film 44 on the bottom is lasting 46 (as shown by dashed lines) and lock the clamp in this position by means of locking holes 52 in the housing 50. Then the panel 28 with grooves for holders of samples, including the sample holders 30 are set to the desired position relative to the bottom plate 46 and push down so that the bottom ends of the specimen holder 30 pass through holes in the plate 46 and further stretch the film 44 on the lower ends of the specimen holder 30, closing their holes 42. Then, the foil 44 is clamped between the panel 28 with the recesses and the bottom plate 46, and used the screws with the notched head 54 for attaching the panel 28 with the grooves to the bottom plate 46. Then the excess film 44 around the perimeter of the panel 28 with grooves cut off.

Mounted panel 28 with the recesses, the specimen holder 30 and the lower plate 46, after loading of the sample holders 30 samples of powder, link together with the steam distribution plate 56 on the mounting rods 26 of the panel 24 with grooves and fix on it, using a system of quick-acting clamps 58. The clamping system 58 is equipped with two pairs of vertical steel rods 60 (figure 5 shows only one pair), mounted on the device for shaking 20, and a pair of clamping bars 62 (figure 5 shows only one), each of which is mounted on a pair of rods 60. Clamping of the strap 62 is fixed relative to the rod locking device 64. In the assembled position, the lower tor the s of the sample holders 30 are located essentially in the center holes of the tubes 26.

The steam distribution plate 56 has an essentially cylindrical through holes (not shown)corresponding to the holes in the panel 28 with the recesses and the bottom plate 46. A pair of channels for inlet and outlet gas pass through wall plate 56, with each pair of channels opens into the corresponding through hole in the plate 56. When the plate 56 link with the panel 28 with the recesses, the specimen holder 30 and the lower plate 46, gazovyye channels is positioned so that the gas flowing into the hole, goes to the bottom end located there sample holder. The gas channels are used for removal of gas into the tubes or formed in them. The bottom surface 66 of the plate 52 is hermetically connected through the elastic layer (not shown), such as Teflon, with the ends of the tubes 26 arranged in the panel 24 with the recesses.

Eight of the agitators in the form of mechanisms for mixing 68 (see in particular figure 2) are mounted on the robotic system 16 using a conventional details in the form of a canopy 70 for transmission systems with actuator rotation 71. The transmission system 71 actuates the stepping motor 72, for example, the engine Vecta CSK™ 23A supplied by Oriental Motors. The transmission system may be a drive belt and a pulley, gear or the ri needed a combination of gears and a system with a drive belt and pulley. Mechanisms for mixing 68 are located on the secondary drive shafts 74 of the transmission system 70 for rotation about their respective vertical axes. Axis is set so that when the mechanisms for mixing (mixer) are above the panel 28 with grooves, they essentially coincide with the axes of the respective through channels 36 of the respective sample holders 30.

The preferred mechanisms for mixing 68 are mechanical scrapers, such as supplied by the company Autodose S.. Such mechanisms for mixing 68 is equipped with two diametrically opposite spring wires 76, which are mounted on their distal end and pass from him in the direction of the axis of the wire 76 four are located essentially in the plane including the corresponding axis. Wire 76 are in unstrained position (shown as 78), in which at least part of the wires 76 is located within the radius from the axis which is greater than the radius of the first holes 40 of the channel 36 of the sample holders 30. When used, the wire 76 is held in tensioned position (shown as 80), in which all wires 76 are located within a radius from the axis which is less than the radius of the first holes 40 of the channel 36 of the specimen holder 30, nl is through what mechanisms for mixing 68 together with their wires 76 can be moved in the direction of the axis relative to the specimen holder 30, and move so that the wire 76 can be inserted into corresponding channels 36 of the sample holders 30. As soon as the wire into the channels 36 of the specimen holder 40, the stopper is removed from the wires 76, which allows the wires 76 to move toward their unstrained position 78 and in contact with the walls 38 of the channel 36.

Wire 76 can be held using any conventional mechanism. For example, this mechanism may include a sleeve (not shown)mounted for reciprocating movement along an axis relative to the wires that gives you the ability to hook the wire 76 and force them to move inside the radius in the direction of the axis or disconnected from the wires and allow them to return to their unstrained position. Preferably the end face of the sleeve which is in contact with the wires, has an internal beveled annular surface which touches the wire.

According to an alternative preferred variant implementation, a pair of plates with holes 82, 84 (see figure 3) is installed on the housing (not shown), which, in turn, is mounted on a robotic system 16 by means of a pneumatic cylinder (not shown). Plates 82, 84 are mounted parallel to each other, while their planes are at right angles to the vertical axis of the mechanisms 68 for mixing, and each of the second plate has eight holes 86, 88, preferably diamond-shaped, located in the Central vertical axes of mechanisms for mixing 68. Plates 82, 84, when combined with each other so that the holes 86, 88 are on the same level with each other (see right side of figure 3), can vertically move with the actuator between a first position in which the plane of the plates 82, 84 intersect the main part of the mechanisms for mixing 68, and a second position in which the plane of the plates 82, 84 cross wire 76 mechanisms for mixing 68 at the point of greatest relationships wires 76 relative to their respective axes. In the second position, the plates 82, 84 can be moved relative to the housing using, for example, pneumatic drives (not shown) at right angles to the vertical axis of the mechanism for mixing, but in opposite directions to each other at equal distances so that the holes 86, 88 are moved to positions in which they are only partially overlapped with each other (see left side of figure 3), with wire 76 are moved to their stretched position 80.

Also on the canopy 70 has two spray beams 90, each beam is placed in parallel to the four sample holders 30 and each beam has four nozzles 92, one nozzle for each neighboring sample holder 30. Gas, ka is the rule, the air from the usual pipeline (shown by arrows 94) served in the nozzle 92 through a separate pneumatic speed limiters 96 and then into the sample holders 30 for providing a forced flow of gas in the holders 30.

The computer (not shown) used to control the operation of robotic systems 16.

When using, in the panel 24 with grooves for receivers samples placed eight tubes 26, which were loaded liquid and other ingredients that may be required. The tubes 26 can be prepared manually or, alternatively, through the use of automated dispensing devices (not shown) under the guidance of the above-mentioned computer or a separate computer, which preferably communicates with the first computer. If necessary, the tube 26 can weigh between each addition of ingredients to ensure that the recipe ingredients are observed and the actual number of ingredients known and recorded.

The panel 28 with grooves for the specimen holder is mounted separately, as described above in relation to figure 4. Then the specimen holder 30 in the assembled unit from the panel 28 with the recesses, the specimen holder 30 and the lower plate 46 download the sample powder. Loading of the specimen holder 30 can be performed manually, but more is edocfile do this automatically, applying automobilului machine (not shown), for example, MTM™, supplied by the company Autodose S.A. Preferably the mass of the sample powder for each sample holder 30 is registered by the computer.

The panel 24 with the recesses, together with the tubes 26 is located on the block ESS (22) and the steam distribution plate (56)is installed over the supporting rods 27 so that it rests on top of the tubes. Then the assembled unit from the panel 28 with the recesses, the specimen holder 30 and the lower plate 46 is placed on the supporting rods 27 so that he was leaning on the steam distribution plate 56. Then, the gripper bars 62 slides in the corresponding pair of rods 60 and engages with the screw notched head 54, thus locking strap 62 is locked in position by a locking device 64 that allows you to secure the entire assembled unit as a whole.

Then, the cooling/heating installation 22, is actuated by computer to balance the temperature of the contents of the test tubes at the required levels, and, if necessary, the gas flow can be introduced and removed from the areas where the bottom ends of the specimen holder 30, to reduce the possibility of condensation on them fluid. The computer then actuates the device for strathewen the I 20 and causes the shaking of liquids in test tubes. After you have achieved external conditions of the experiment, the canopy 70 is lowered to insert the mechanisms for mixing 68 in the respective sample holders 30. Then the plates 82, 84 move when combined with each other, which allows the wires 76 mechanisms for mixing 68 to move in their unstrained position 78. Then the plate is moved vertically upward so that they are freed from wires 76. In this position mechanisms for mixing, if the specimen holder 30 has been placed in more than one powder, mechanisms for mixing 68 can be controlled in such a way as to ensure mixing of the powder samples in the sample holders 30.

Then the mechanisms for mixing 68 move lower in the direction of the axis to engage the wire 76 and validate the latex film, sealing the second hole 42 of the specimen holder 30, with latex film is torn and removed from the holes 42. Then the mechanisms for mixing 68 slightly divert and regulate for mixing samples of the powder, which causes the sample to move through the openings 42 into the respective tubes 26. The rate of dispensing powder samples of the sample holders 30 can be adjusted by controlling the speed of wires 76 and reciprocating motion mechanisms on the I mixing 68 in a vertical direction relative to the specimen holder. When essentially all of the sample powder is moved into the appropriate tubes, initiate a short gas flow through a nozzle 92 in each sample holder to blow off any remaining particles of the sample powder.

The use of an elastic film 44 as the valve mechanism leads to effective immediate opening hole 42 without contamination of the contents of the tubes 26. Although, as was discovered, the metal foil is an alternative choice, it theoretically from time to time may cause the contents of the tubes may be contaminated with pieces of foil, accidentally torn wires 76.

As soon as the operation of the tubes 26, for example, the relevant terms of cooling or heating were performed, the tube 26 can be removed for further processing, research, characterization and analysis of their content.

1. The method of parallel dispensing powder samples of materials, including:
a) providing at least two sample holders powder, each of which has a through channel with a first opening through which the powder is introduced into the channel, and a second opening through which the powder, providing this capability derives from the channel;
b) introducing a sample of the powder in the respective sample holders;
c) combining vtoro what about the holes of each bracket with the hole corresponding receiver samples; and
d) providing, in essence, the simultaneous flow of powder through the second hole when mixing the powder samples in the channels to facilitate their promotion of the channels in the corresponding receivers
characterized in that the method further includes stretching the elastic film on each of the holes and the fixing film relative to the corresponding sample holder for sealing the second hole and, at the stage d), the perforation of the film, sealing each of the second holes.

2. The method according to claim 1, including the use of sample holders, which generally taper from the first hole to the second hole.

3. The method according to claim 1, comprising sealing the second hole of the specimen holder to the introduction of a sample powder.

4. The method according to claim 1, comprising, in stage d), the speed control dispensing of samples of the powder through the second hole.

5. The method according to claim 1, including after the sample powder mainly flow through the second holes, the initiation of the forced gas flow through the first hole in each of the sample holders.

6. The method according to claim 1, comprising, during stage d), the direction of the forced gas flows out from the second hole.

7. Device for parallel dispensing powder samples, including at IU is greater least two sample holders for keeping samples of the powder, each sample holder has a through channel with a first opening through which the sample powder is introduced into the channel, and a second opening through which the sample powder is derived from a channel, the corresponding device flow control to regulate the flow of powder passing through each of the second holes, and a mixing device for mixing the sample powder in each sample holder during use of the device,
characterized in that the device flow control for sample holder includes an elastic film, sealing the second hole.

8. The device according to claim 7, in which each end-to-end channel of each sample holder in a generally tapers from the first hole to the second hole.

9. The device according to claim 7, equipped with more than two sample holders.

10. The device according to claim 7, in which the mixing device includes a punch for punching an elastic film and mounted for movement along an axis through the channel, resulting in it hole-punches film.

11. The device according to claim 7, in which the mixing device is in contact with the wall bounding the channel.

12. The device according to claim 7 in which each of the mixing devices mounted on a common supporting element, a reciprocating postupatel the e movement of which relative to the dispensing position of the specimen holder causes simultaneous reciprocating movement of the agitator relative to the specimen holder.

13. The device according to claim 7, in which the mixing device includes mechanisms for mixing, each of which has at least one spring wire mounted for rotation around an axis that is essentially coincident with the axis of the channel, and at least one wire installed in the plane that includes the specified axis of rotation.

14. The device according to item 13, in which at least one wire has a loose position in which at least part of the wire is the radius from the axis which is greater than the radius of the first opening of the channel sample holder, and the device further includes a limiting mechanism in the first position holds at least one wire in a tense position, in which indicated at least one wire located within a radius from the axis which is less than the radius of the first hole and the second position does not impose any restrictions on the specified at least one wire, thereby allowing the specified at least one wire to move radially outward toward its unstrained position.

15. The device according to 14, in which the restraining mechanism includes a pair of parallel plates, each of which has a number of holes corresponding to the share of the Wu mechanisms for mixing, moreover, the plates are placed on mechanisms for mixing so that their planes are at right angles to the axes of the mechanisms for mixing and when the holes in the plates coincide with each other, the centers of holes are arranged essentially coaxially aligned with the corresponding axes of the mechanisms for mixing, and the plate can move relative to each other between a first position in which the plates are aligned with each other, and in which the wire mechanisms for mixing are in their unstrained position and a second position in which the holes in them only partially coincide with each other, and in which wire mechanisms for mixing are held in their tensioned position.

16. The device according to item 15, in which both plates can be moved symmetrically with respect to the axes of mechanisms for mixing.

17. The device according to claim 7, comprising nozzle means through which the gas stream can be directed in each sample holder through the first hole.

18. The device according to item 13, in which for speed control of dispensing powder samples of the sample holders regulate the speed of rotation of mechanisms for mixing and vertical reciprocating motion mechanisms for mixing relative to the location holding the oil samples.

19. The device according to claim 7, including Gazovye device for gas flow to the outer bottom wall of each sample holder.

20. The device according to claim 7, including the gas a device for removing gas from the outer bottom wall of each sample holder.

21. The device according to claim 7, including a library of sample powder comprising at least two holders for samples containing samples of the powder, and the specimen holder is temporarily sealed, with each sample holder has a through channel, which basically narrows from the first opening through which the sample powder is introduced into the channel, and a second opening through which the sample powder, providing this capability derives from the channel.

22. Application of the method according to any one of claims 1 to 6 to create libraries of powder samples by sample preparation powder and dispensing samples in at least two sample holders for keeping samples of powder, and a temporary sealing holders of samples in which each sample holder has a through channel, which basically narrows from the first opening through which the sample powder is introduced into the channel, and a second opening through which the sample powder, providing this capability derives from the channel.



 

Same patents:

Sampling device // 2449086

FIELD: construction, road engineering.

SUBSTANCE: invention relates to construction and may be used to monitor and investigate a core sample from wells and structures. The sampling device comprises a sampler, where one end of a rope is fixed, and the other end is fixed on the sampler. At the same time a device of sampler retention is made of a torus, which is covered on top with an adhered industrial rubber fabric, which serves as a roof. The surface of the torus and roof forms a tight cavity, where vacuum is pulled as the torus is blown. Atmospheric pressure pushes the shell and the cover and presses it to road surface. When the sampler is pressed into the earth bed, it stops against the rope connected to the sampler retention device.

EFFECT: sampler retention on the road surface.

2 dwg

FIELD: metallurgy.

SUBSTANCE: invention refers to investigation of structure of high-strength steels. Method involves interaction of tube steel specimen with water solution of sulphosalts, further flushing and drying of specimen and detection of areas of bainite of rack morphology by means of optic microscope. At that, after application to specimen surface of water solution of sulphosalts, there removed is formed film, and bainitic areas are detected by means of polarised light of optic microscope; after that, obtained pictures of specimen are fixed and parameters of the detected bainitic areas of rack morphology are determined.

EFFECT: method allows detecting structure of high-strength tube steel as a result of evaluation of which the conclusion can be made on metallurgical quality of tube steel.

4 dwg

FIELD: agriculture.

SUBSTANCE: invention relates to agriculture and, in particular, to determine the loss of ripe grains from auto-falling growing. The method consists in the fact that the area of the field is chosen, a frame is put on it passing through the density, the grain falling from the spike and got into intra-frame space is harvested. At that before the observations, the inter-stem space between the soil surface and the upper edges of the frame is filled with free-flowing material, which upper layer is moistened and covered with a thin layer of fast-curing material, and the area around the frame is mowed at least for the length of the density. In addition, another frame of the same area with sides of greater heights is put on this frame.

EFFECT: method enables to increase accuracy of determination of grain loss.

2 cl, 2 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: paraffin sections are prepared, fixed, coated with a colloidal developer prepared by mixing 2% aqueous gelatin in 1% formic acid and 50% aqueous AgNO3 in equal proportions, incubated for 30-60 minutes, washed and contrasted. The material is fixed in 10% neutral buffered formalin (pH 7.4) for 24 hours. The material is finished in ascending alcohols, encapsulated in paraffin to prepare the sections which are prepared in 2% formic acid in 96% ethanol for 20 minutes, dehydrated in 2 portions of 96%; the sections are prepared in 0.1% NaOH for 2 min 30 sec. Then they are dried. One drop of 100% AgNO3 is layered on the preparation. It is followed by incubation in a thermostat at 60°C for 1 min 40 sec in a humid chamber, and coating with one drop of 40% formaldehyde and colloidal developer. It is incubated for 20-50 seconds in the thermostat at the same temperature. The sections are washed in 4 portions of distilled water. The sections are processed with acetate buffer pH 2.4 for 1 minute; the preparations are contrasted with 0.2% aqueous methyl green for 10-15 seconds, purified in chloroform, differentiated for 2-3 minutes in n-butyl alcohol, processed in toluene and encapsulated in polystyrene.

EFFECT: higher quality of detection and evaluation of nucleolar organisers.

1 ex, 2 dwg

FIELD: medicine.

SUBSTANCE: method for in vitro recovery of experimental tuberculous granulomas in culture involves induction of granulomatous inflammation by infecting experimental animals with BCG mycobacteria, recovery and mechanical disintegration of spleen tissues containing granulomas over a period adequate to form them in an animal's body, homogenisation of spleen tissue in a solution by agitation, purification of the homogenate from coarse tissue fragments by spontaneous deposition in a culture medium, removal of the deposits, recovery of the granulomas from a supernatant, washing in a new portion of the culture medium by centrifugation at acceleration 15-28 g at least three times and transfer of the deposited granuloma in the culture medium.

EFFECT: effective granuloma integrity and higher purity of the recovered granulomas.

4 cl, 3 ex

FIELD: physics.

SUBSTANCE: method involves insulating a capillary section where the detection window is located with radical polymerisation in the quartz capillary. Radical polymerisation of the reaction mixture in the capillary is initiated via electron-beam processing by exposing the reaction mixture to accelerated electrons at absorbed dose values ranging from 25 to 75 kGy. The outer polyimide layer is removed with drops of hot sulphuric acid while simultaneously washing the column with a cooling liquid or a liquid-gas mixture.

EFFECT: high reliability and a simple method of making a detection window.

2 cl, 2 ex

FIELD: machine building.

SUBSTANCE: proposed system comprises first assembly to direct gas sample from sampling site to gas characteristics measurement site. First assembly contains components to get in contact with gas sample in operation and gas sampling tube. System includes sample analyser area to measure characteristics of, at least, one component in gas sample, and second assembly outside of the first assembly during all time of operation so that all components of second assembly do not get in contact with gas sample. Note here that second assembly comprises pump connected with said tube to feed gas there through into analyser area without contact with gas sample. Second assembly comprises flow measuring device to get data on gas flow sample, gas pressure gage, or whatever combination of pump, flow measuring device or gas pressure gage.

EFFECT: preventing contamination of reusable components, lower production costs, ease of maintenance.

33 cl, 9 dwg

FIELD: physics.

SUBSTANCE: probe is a sealed container which is connected by a conducting rope to a control unit and has a system of containers connected in parallel by hoses for gathering water samples and a sampling tube, one end of which is connected through an electromagnetic valve to a system of containers, and the second end of which has holes for inlet of void water and is fitted with a filter. The void water container is in form of syringes whose piston rods are locked by spring-loaded locks so as allow their unlocking and filling the syringes with water depending on the immersion horizon of the sampling tube in the sediments. The probe is fitted with a mechanism for immersion of the sampling tube and a system for monitoring its immersion depth in the sediments.

EFFECT: design of the sampling tube enables to increase the depth of water bodies from which samples can be collected in situ, increases efficiency and quality of the collected samples and cuts the time spent on collecting samples.

7 cl, 1 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to dentistry. Diagnosis of generalised periodontitis is enabled by examining crevicular fluids by V-dehydration technique. The presence of three exactly localised facies regions makes it possible to state normal condition of periodontium tissues. The presence of arched cracks in an edge region provides diagnosing slight generalised periodontitis. The presence of arched cracks in the edge region and a band of the lower wave edge region, the absence of an intermediate region and a typical crystalline structure in the central region provides diagnosing a moderate degree. If observing a tendency to fusion of all facies regions and the presence of beam-like cracks in the edge region enables diagnosing severe generalised periodontitis.

EFFECT: technique enables diagnosing generalised periodontitis and determining its severity.

5 dwg

FIELD: measurement.

SUBSTANCE: device is comprised of the first and second part. The first part contains the edge piercing the membrane, capillary channel and a hole in the outer surface of the first part. The second part comprises the chamber for processing solution and the membrane closing the chamber for processing solution. Wherein the hole is opened when the first part of the device is initially put into the second part of the device, and the hole is closed when the first part of the device is fully put into the second part of the device. Capillary channel made in the first part of the device is sized for receiving the liquid medium sample. The second part is comprising the chamber for processing solution that can be limited by first and second membranes, wherein the first part gets through the first membrane when the first part is put into the second par in such a way that the content of processing solution chamber is mixed with the content of capillary channel. The tool for piercing the second membrane is made in such a way that the content of processing solution chamber and capillary channel can be forced out of the device. The device can also comprise the plunger with the mechanism for getting through the second membrane in such way that the content of processing solution chamber and capillary channel is forced through the plunger.

EFFECT: increased pressure control in the device when supplying necessary amount of sample into analyzing cartridge.

4 cl, 16 dwg

Sampling device // 2449086

FIELD: construction, road engineering.

SUBSTANCE: invention relates to construction and may be used to monitor and investigate a core sample from wells and structures. The sampling device comprises a sampler, where one end of a rope is fixed, and the other end is fixed on the sampler. At the same time a device of sampler retention is made of a torus, which is covered on top with an adhered industrial rubber fabric, which serves as a roof. The surface of the torus and roof forms a tight cavity, where vacuum is pulled as the torus is blown. Atmospheric pressure pushes the shell and the cover and presses it to road surface. When the sampler is pressed into the earth bed, it stops against the rope connected to the sampler retention device.

EFFECT: sampler retention on the road surface.

2 dwg

FIELD: metallurgy.

SUBSTANCE: invention refers to investigation of structure of high-strength steels. Method involves interaction of tube steel specimen with water solution of sulphosalts, further flushing and drying of specimen and detection of areas of bainite of rack morphology by means of optic microscope. At that, after application to specimen surface of water solution of sulphosalts, there removed is formed film, and bainitic areas are detected by means of polarised light of optic microscope; after that, obtained pictures of specimen are fixed and parameters of the detected bainitic areas of rack morphology are determined.

EFFECT: method allows detecting structure of high-strength tube steel as a result of evaluation of which the conclusion can be made on metallurgical quality of tube steel.

4 dwg

FIELD: agriculture.

SUBSTANCE: invention relates to agriculture and, in particular, to determine the loss of ripe grains from auto-falling growing. The method consists in the fact that the area of the field is chosen, a frame is put on it passing through the density, the grain falling from the spike and got into intra-frame space is harvested. At that before the observations, the inter-stem space between the soil surface and the upper edges of the frame is filled with free-flowing material, which upper layer is moistened and covered with a thin layer of fast-curing material, and the area around the frame is mowed at least for the length of the density. In addition, another frame of the same area with sides of greater heights is put on this frame.

EFFECT: method enables to increase accuracy of determination of grain loss.

2 cl, 2 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: paraffin sections are prepared, fixed, coated with a colloidal developer prepared by mixing 2% aqueous gelatin in 1% formic acid and 50% aqueous AgNO3 in equal proportions, incubated for 30-60 minutes, washed and contrasted. The material is fixed in 10% neutral buffered formalin (pH 7.4) for 24 hours. The material is finished in ascending alcohols, encapsulated in paraffin to prepare the sections which are prepared in 2% formic acid in 96% ethanol for 20 minutes, dehydrated in 2 portions of 96%; the sections are prepared in 0.1% NaOH for 2 min 30 sec. Then they are dried. One drop of 100% AgNO3 is layered on the preparation. It is followed by incubation in a thermostat at 60°C for 1 min 40 sec in a humid chamber, and coating with one drop of 40% formaldehyde and colloidal developer. It is incubated for 20-50 seconds in the thermostat at the same temperature. The sections are washed in 4 portions of distilled water. The sections are processed with acetate buffer pH 2.4 for 1 minute; the preparations are contrasted with 0.2% aqueous methyl green for 10-15 seconds, purified in chloroform, differentiated for 2-3 minutes in n-butyl alcohol, processed in toluene and encapsulated in polystyrene.

EFFECT: higher quality of detection and evaluation of nucleolar organisers.

1 ex, 2 dwg

FIELD: medicine.

SUBSTANCE: method for in vitro recovery of experimental tuberculous granulomas in culture involves induction of granulomatous inflammation by infecting experimental animals with BCG mycobacteria, recovery and mechanical disintegration of spleen tissues containing granulomas over a period adequate to form them in an animal's body, homogenisation of spleen tissue in a solution by agitation, purification of the homogenate from coarse tissue fragments by spontaneous deposition in a culture medium, removal of the deposits, recovery of the granulomas from a supernatant, washing in a new portion of the culture medium by centrifugation at acceleration 15-28 g at least three times and transfer of the deposited granuloma in the culture medium.

EFFECT: effective granuloma integrity and higher purity of the recovered granulomas.

4 cl, 3 ex

FIELD: physics.

SUBSTANCE: method involves insulating a capillary section where the detection window is located with radical polymerisation in the quartz capillary. Radical polymerisation of the reaction mixture in the capillary is initiated via electron-beam processing by exposing the reaction mixture to accelerated electrons at absorbed dose values ranging from 25 to 75 kGy. The outer polyimide layer is removed with drops of hot sulphuric acid while simultaneously washing the column with a cooling liquid or a liquid-gas mixture.

EFFECT: high reliability and a simple method of making a detection window.

2 cl, 2 ex

FIELD: machine building.

SUBSTANCE: proposed system comprises first assembly to direct gas sample from sampling site to gas characteristics measurement site. First assembly contains components to get in contact with gas sample in operation and gas sampling tube. System includes sample analyser area to measure characteristics of, at least, one component in gas sample, and second assembly outside of the first assembly during all time of operation so that all components of second assembly do not get in contact with gas sample. Note here that second assembly comprises pump connected with said tube to feed gas there through into analyser area without contact with gas sample. Second assembly comprises flow measuring device to get data on gas flow sample, gas pressure gage, or whatever combination of pump, flow measuring device or gas pressure gage.

EFFECT: preventing contamination of reusable components, lower production costs, ease of maintenance.

33 cl, 9 dwg

FIELD: physics.

SUBSTANCE: probe is a sealed container which is connected by a conducting rope to a control unit and has a system of containers connected in parallel by hoses for gathering water samples and a sampling tube, one end of which is connected through an electromagnetic valve to a system of containers, and the second end of which has holes for inlet of void water and is fitted with a filter. The void water container is in form of syringes whose piston rods are locked by spring-loaded locks so as allow their unlocking and filling the syringes with water depending on the immersion horizon of the sampling tube in the sediments. The probe is fitted with a mechanism for immersion of the sampling tube and a system for monitoring its immersion depth in the sediments.

EFFECT: design of the sampling tube enables to increase the depth of water bodies from which samples can be collected in situ, increases efficiency and quality of the collected samples and cuts the time spent on collecting samples.

7 cl, 1 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to dentistry. Diagnosis of generalised periodontitis is enabled by examining crevicular fluids by V-dehydration technique. The presence of three exactly localised facies regions makes it possible to state normal condition of periodontium tissues. The presence of arched cracks in an edge region provides diagnosing slight generalised periodontitis. The presence of arched cracks in the edge region and a band of the lower wave edge region, the absence of an intermediate region and a typical crystalline structure in the central region provides diagnosing a moderate degree. If observing a tendency to fusion of all facies regions and the presence of beam-like cracks in the edge region enables diagnosing severe generalised periodontitis.

EFFECT: technique enables diagnosing generalised periodontitis and determining its severity.

5 dwg

FIELD: measurement.

SUBSTANCE: device is comprised of the first and second part. The first part contains the edge piercing the membrane, capillary channel and a hole in the outer surface of the first part. The second part comprises the chamber for processing solution and the membrane closing the chamber for processing solution. Wherein the hole is opened when the first part of the device is initially put into the second part of the device, and the hole is closed when the first part of the device is fully put into the second part of the device. Capillary channel made in the first part of the device is sized for receiving the liquid medium sample. The second part is comprising the chamber for processing solution that can be limited by first and second membranes, wherein the first part gets through the first membrane when the first part is put into the second par in such a way that the content of processing solution chamber is mixed with the content of capillary channel. The tool for piercing the second membrane is made in such a way that the content of processing solution chamber and capillary channel can be forced out of the device. The device can also comprise the plunger with the mechanism for getting through the second membrane in such way that the content of processing solution chamber and capillary channel is forced through the plunger.

EFFECT: increased pressure control in the device when supplying necessary amount of sample into analyzing cartridge.

4 cl, 16 dwg

FIELD: mechanics.

SUBSTANCE: invention includes frame with bunker installed on it; bunker has a gate at the outlet; neck with sealing mechanism is installed under bunker; the above mechanism is equipped with bag hold-down clamps; neck is connected to weight measuring mechanism made in the form of balance arm that has counter-balance on the other end. There is also accurate weight adjustment device, gate position adjustment device and dosing cutoff device. Gate for high and low dosing flows is common. Weight accurate adjustment device is made in the form of adjusted spring hinged to one end of the balance arm, and two adjusted stops for restriction of amplitude of oscillation of this end on the neck end; at that, the second end of balance arm is equipped with adjustable pusher for interaction with the dosing cutoff device. Dosing cutoff device is fixed on the frame and made in the form of contact platform with possibility of adjusting by means of a screw and a roller, which are connected to each other by means of articulation system. At that, platform and roller are equipped with their own counterbalances, and roller has the possibility of interaction with the gate position adjustment device. Gate position adjustment device is made in the form of rod with cam, which is adjusted as to length and kinematically connected to the gate, for interaction with roller of the dosing cutoff device. Neck has rectangular section.

EFFECT: simpler design and lower cost of the bench; increasing the efficiency and dosing accuracy.

1 dwg

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