Method for producing polymer complex possessing antiseptic properties and based antiseptic coating

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, more specifically to a technology of a polymer coating applicable for the purpose of protecting inorganic materials (metals, ceramics), synthetic polymers against surface microorganism growth. What is described is a method of synthetic metal working, including silicate glass and synthetic polymers that consists in formation of surface coatings of mixed polyvinyl butyral and dimethylalkylbenzylammoniumchloride complex containing alkyl group C8 to C16, with styrene maleic anhydride copolymer, preliminary chemically modified for opening, anhydride cycles to form carboxylate groups.

EFFECT: prolonged metal, silicate glass and synthetic polymer protection against microorganisms.

24 ex

 

The present invention relates to the production technology of polymer coating that helps protect inorganic materials (metals, ceramics), the fabrics of synthetic polymers from microbial growth on their surface.

Most effectively the invention can be used in objects, which imposed requirements on the level of microbial load.

The relevance of the developed method is determined by the necessity of using products from metals, ceramics, and synthetic polymers in the presence of people on the objects, areas, etc. where regulated microbial load, and hermozamente premises, which do not permit the growth of microorganisms on the surface of the material even in conditions of high humidity.

Known (patent RF №2163489 C1, CL 7 A61L 2/16, 2007; patent RF №2214452 C1, CL 7 C11D 3/48, 2003; RF patent №2279275, CL AC 31/14, 2006) low molecular weight compounds containing Quaternary ammonium group with a long-chain alkyl Deputy, in particular katamin AB with high antimicrobial properties. However, they cannot be used as a component of the coating, as dissolved in water, which leads to their removal and wypadaniu of the last operation.

Known polyelectrolyte complexes catamine AB with poly the apostrophes, containing acid groups, in which katamin AB is associated with a chain of the macromolecule ionic bond. In particular, the complex catamine AB with a copolymer of N-vinylpyrrolidone with crotonic acid (USSR author's certificate No. 1607359 A1, class 6 C08F 226/10, 1995). This polymer complex containing Quaternary ammonium groups with a long-chain alkyl substituent in as counterion, has a strong antiseptic effect. Similar action has complex catamine AB with carboxymethylcellulose proposed (patent RF №2146136 C1, CL 7 AC 31/14, 2000) as an antiseptic. However, both of the above complex are water-soluble and cannot be used as a film antiseptic protective coating.

The closest in technical essence and the achieved result of the present invention is a method (patent WO 2007/024973 A1, CL A01N 25/32), where as antimicrobial coatings are used polymethacrylates, polyurethanes, derivatives of polyvinyl-benzylchloride and other polymers containing covalently associated with the chain of the macromolecule a Quaternary ammonium group with a long-chain substituent. These polymers are not soluble in water, but soluble in alcohols, from solutions which can be formed by coating. However, in the monograph (Afinogenov G., Panari the E.F. Antimicrobial polymers. SPb. Hippocrates, 1993, 264 S.) and review (Panarin E.F., Kopeikin CENTURIES-Molecular compound. Series C. 2002, t, No. 12, s-2351) for numerous examples show that the antimicrobial properties of polymers containing covalently linked Quaternary ammonium group, below antimicrobial properties similar model of low molecular weight Quaternary ammonium compounds and polyelectrolyte complexes of ionic surfactants, in which the Quaternary ammonium groups with a long-chain alkyl Deputy linked to the main chain of the polymer ionic bond.

The technical result is prolonged protection of metals, silicate glass, and synthetic polymeric materials from exposure to microorganisms.

This technical result is achieved by the proposed method, antiseptic treatment of metals, silicate glass, and synthetic polymeric materials, which consists in forming on the surface coating of a mixture of polyvinyl butyral with complex dimethylammoniumchloride containing alkyl group from C8to C16with a copolymer of styrene with maleic anhydride, previously subjected to chemical modification to the disclosure of anhydrite cycles with the formation of carboxylate groups.

The coating formed is ovali on samples of materials, which surface pre-clean flannel cloth or cotton-gauze swab soaked in ethyl or isopropyl alcohol. The coating was applied with a brush, evenly distributed across the surface of the sample. The operation was repeated three times. After the coating was dried in the air. Solutions for the preparation of coatings were prepared by mixing the solution of the complex with a solution of polyvinyl butyral in a predetermined ratio, followed by stirring the obtained solution with a magnetic stirrer until a homogeneous mass. Chemical modification of a copolymer of styrene with maleic anhydride in order to disclose the anhydrite cycles in parts of the maleic anhydride with the formation of carboxylate groups was carried out with aqueous solutions of hydroxides of sodium or potassium. To do this in a flat-bottomed flask, equipped with reflux condenser and magnetic stirrer, was loaded copolymer and an aqueous solution of alkali metal hydroxide at the rate of 2 mol of hydroxide at 1 mol-link maleic anhydride copolymer. The process is conducted in a boiling water bath for 2 hours, the resulting copolymer was passed into the solution. For more complex dimethylammoniumchloride this solution chemically modified copolymer with vigorous stirring and mixed with the aqueous solution of dimethylallyl is intramolecularly. The last was taken in a reaction rate of 1 mole per 1 g-EQ. carboxylate groups in chemically modified copolymer. The complex was separated from solution as a white precipitate, which was washed with water and dried in vacuum at 40°C.

When testing the antimicrobial activity of the coatings were determined not only by its fungicidal, but bactericide properties on the duration and degree of protection materials in conditions periodically generated high microbial load. Evaluation of antimicrobial activity of the samples was conducted by determining gribomont in points according to GOST 9.050-75 method a and in relation to bacterial and fungal Association, which has been prepared in an environment of čapek-doksa, diluted with distilled water in the ratio 1:5. The Association of the cultures consisted of Staphylococcus epidermidis, Bacillus polymyxa, Bacillus pumilus, Penicillium expansum, Aspergillus niger and Cladosporium cladosporioides, which have monthly inoculable 5 samples of materials to each experience to obtain reliable data. The content of each species in the mixture was 1×105-2×105colony forming units (CFU) on 1 cm2square. To determine the number of viable units of microorganisms on the studied materials contaminated samples, placed in a thermostat, incubated at 28°C and a relative humidity ≥90% within 3 months with sampling at 0 hours. Then the samples otbelivanie in 10 ml of physiological solution and washings were sown in 0.2 ml of the original suspension on the surface of nutrient media: protection of čapek-doksa to determine CFU of fungi, medium meat-peptone agar to determine CFU of bacteria.

The following examples illustrious the proposed method for the fabrication of polymeric complex and antiseptic coating on metals, silicate glass and materials from synthetic polymers.

Example 1. To obtain a copolymer of styrene with maleic anhydride copolymerization was carried out in boiling benzene in a 3-necked round bottom flask fitted with mechanical stirrer, reflux condenser and thermometer. Download: benzene - 509 ml, maleic anhydride - 49 g (0.5 mole), styrene - 52 g (57.4 ml of 0.5 mol), the initiator 2,2'-azobis(isobutyronitrile) - 0,5, during copolymerization, the copolymer was allocated in the form of a white solid residue, which upon completion of the process (20 min) was separated from the solution on a Buechner funnel, washed three times with fresh portions of hexane and dried in a vacuum drying Cabinet at a temperature of 80°C. According to titration and elemental analysis of the copolymer contains 53 mol-link % parts of maleic anhydride and has srednevozrastnoe molecular weight of 3.2×105. A modification of this copolymer was performed with an aqueous solution of sodium hydroxide. To do this, in flat-bottomed to the BU, equipped with reflux condenser and magnetic stirrer, was loaded 4,74 g (24,9 mmol-link maleic anhydride) copolymer and 1.99 g (49,8 mmol) of sodium hydroxide dissolved in 130 ml of water. The process is conducted in a boiling water bath for 2 hours. At the end of the process the whole copolymer is passed into the solution. This smilenov copolymer was obtained complex with Catalina AB (dimethylallyl(C12-14)benzylammonium). To do this, 8,3 g 50% aqueous solution of catamine AB under vigorous stirring was added to 28.5 ml of 5.26% solution of a copolymer, in which the parts of maleic anhydride modified with the formation of carboxylate groups as described above. There were white resinous precipitate the complex. This precipitate was washed with water and dried in a vacuum drying Cabinet at 40°C. the Coating on the plates of aluminium alloy was formed from a solution in isopropyl alcohol mixture solution in the ratio of 1:3 by volume of this complex (concentration 5 g/DL) and polyvinyl butyral (concentration 5 g/DL) mark "Mowital B60T"containing 69-72 wt.% acetylenic links, 2 wt.% acetate units and from 24 to 27 wt.% the residual parts of vinyl alcohol. Maintenance of the complex in the coating - 25 wt.%. After applying the solution was dried in air at room temperature.

For the evaluation of antimicrobial activity of the coating samples of aluminum alloy which I have 3 times the infected bacterial-fungal Association. Table 1 presents the content of SOME bacteria and fungi these samples and samples of the prototype. As control was used samples of aluminium alloy uncoated.

Table 1
The content of bacteria and fungi (CFU) of example 1, the sample prototype and the control sample without coating
Example No.3x infection
bacteriamushrooms
10*0*
the placeholder4,0×1041,8×103
control5,0×l07of 3.2×105
Note: 0* - content of less than 50 CFU in the sample at 5-fold replication sample

As can be seen from this table that the number of microorganisms with 3-fold contamination on the samples of the prototype was significantly lower than in control samples (a difference of 2 orders of magnitude), and the samples of this example was significantly lower than in the samples of the prototype of the and. Funginertness samples according to GOST 9.050-75 matches in example 1 is equal to 0 points, prototype equal to 2 points, while the control sample is equal to 4 points.

Examples 2-7. The coating on the plates of aluminium alloy was formed as described in example 1, from solutions in isopropyl alcohol, mixtures of solutions of the complex, synthesized as described in example 1, and polyvinyl brand "Mowital B60HH"containing 81-84 wt.% acetylenic links, 2 wt.% acetate units and 12 to 16 wt.% the residual parts of vinyl alcohol, for different ratios of components in the mixture. Table 2 shows the antimicrobial properties of these coatings is the average number of fungi and bacteria remaining on the surface of the samples.

Table 2
The compositions of the coatings on the plates of aluminium alloy, the growth of fungi in points and the content of bacteria and fungi (CFU)
Example No.The composition, wt.%The growth of fungi, pointsSOME
the complex of example 1polyvinyl-butyralmushroomsbacteria
2100-000
37525000
45050000
52575000
6109012×102of 4.2×103
75952of 4.6×104of 2.2×104

From the data of this table shows that the coatings of examples 6 and 7 do not provide a complete inhibition of growth of microorganisms, although the coating in example 6 better inhibits the growth of microorganisms than floor-prototype. From the company who stood in examples 2 and 3 are formed sticky wax-like coating. Solid non-sticky coatings formed from the compositions according to examples 4-7.

Examples 8-13. The coating on the plates of stainless steel 12X18H10T, silicate glass, polymethylmethacrylate and the films of polyimide type PM-1E, polyethylene terephthalate and polyamide-12 formed as described in example 1 from a solution in isopropyl alcohol of a mixture of solutions of the complex, synthesized as described in example 1, and polyvinyl brand "Mowital B60T", which is used for preparation of the coating of example 1. Maintenance of the complex in the coating - 25 wt.%.

The average number of bacteria and fungi in these examples is presented in table 3.

Table 3
The growth of fungi and the presence of bacteria and fungi (CFU) on samples of different materials with coatings of example 1
Example No.MaterialThe growth of fungi, pointsSOME with 3-fold infection
bacteriamushrooms
8stainless steel00 0
9silicate glass000
10the polyimide000
11the polyethylene terephthalate000
12polyamide-12000
13polymethylmethacrylate000

Example 14. The coating on the artificial skin "Talka-1"representing a composite material consisting of a layer of polymeric material and knitting basics. The layer of polymeric material consists of a mixture of PTFE-26, fluoro SCF-26 and fluoroplastic f-NTD filled with titanium dioxide, a gas soot and other pigments. The coating layer side resin material formed as described in example 1 from a solution in isopropyl alcohol, which was used to prepare coatings for the example 1. Maintenance of the complex in the coating - 25 wt.%.

On the thus formed covering the growth of fungi according to GOST 9. 050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

Examples 15 and 16. The coating on the plates of the silicate glass formed as described in example 1, from solutions in isopropyl alcohol, mixtures of complex, synthesized as described in example 1, with polyvinylbutyral differing content acetylenic and vinylstyrene links, when the content of complex mixtures - 25 wt.%. The butyral brand "Mowital B30H contains 75-78 wt.% acetylenic links, 3 wt.% acetate units and 18-21 wt.% the residual parts of vinyl alcohol. The butyral brand "Mowital B30T contains 68-72 wt.% acetylenic links, 3 wt.% acetate units and from 24 to 27 wt.% the residual parts of vinyl alcohol.

On the thus formed coating the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

Example 17. To obtain a copolymer of styrene with maleic anhydride copolymerization was carried out in dried ethyl ketone at boiling point in a 3-necked flask fitted with mechanical stirrer, reflux condenser with a dropping funnel and a thermometer. Download: ethyl ketone 40 ml, maleic anhydride and 9.8 g (0.1 mole), styrene - 10.4 g (11,4 ml, 01 mole), the initiator 2,2'-azobis(isobutyronitrile) - 0,6, a Solution of maleic anhydride in ethyl ketone was loaded into a 3-necked flask and brought to a boil. To this solution is added dropwise during 40 min under vigorous stirring was added an initiator solution in styrene. Then the process is continued 110 minutes At the end of the process the copolymer from solution besieged in the form of a white powder with petroleum ether and separated from the solution on a Buechner funnel, washed three times with fresh portions of petroleum ether and dried in a vacuum drying Cabinet. According to the elemental analysis of the copolymer contains 61 mol-link % parts of maleic anhydride and 39 mol-link % links styrene. Srednevozrastnoe molecular weight of this copolymer is 2.4×104. A modification of this copolymer was performed with an aqueous solution of sodium hydroxide under the same conditions as in example 1. To this flask was loaded 2,98 g (18,1 mmol-link maleic anhydride) and 1.45 g (36,2 mmol) of sodium hydroxide dissolved in 40 ml of water. The complex of this modified copolymer with Catalina AB also synthesized as described in example 1. For this to 5 ml of 11.4% aqueous solution of a copolymer, in which the parts of maleic anhydride modified with the formation of carboxylate groups, with vigorous stirring was added of 14.46 ml 10,97% aqueous solution of catamine AB. There were white the precipitate of the complex, which was washed with water and dried in a vacuum drying Cabinet at 40°C. the Coating on the plates of aluminium alloy was formed as described in example 1 from a solution in isopropyl alcohol of a mixture of equal volumes of solutions of this complex (concentration 5 g/DL) and polyvinyl brand "Mowital B60HH" (concentration 5 g/DL), which is used to prepare the coatings in examples 2-7. Maintenance of the complex in the coating - 50 wt.%.

On the thus formed covering the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

Example 18. Synthesis of a copolymer of styrene with maleic anhydride and its modification was carried out similarly to example 1. The synthesis of this complex modified copolymer with dimethyldioctadecylammonium was carried out as follows. To 30 ml of a 13% aqueous solution of dimethyldioctadecylammonium with vigorous stirring at a temperature of 35-40°C was added 29 ml of 3.6% aqueous solution of a copolymer, in which the parts of maleic anhydride modified with the formation of carboxylate groups. There were white precipitate of the complex. This precipitate was washed with water at a temperature of 35-40°C and dried in a vacuum drying Cabinet at 40°C. the Coating on silicate glass formed as described in example 1 from a solution in isopropyl alcohol mixture is of rastvorov this complex (concentration of 5.8 g/DL) and polyvinyl butyral (concentration of 5.1 g/DL) mark "Mowital B60T", used for preparation of the coating of example 1. Maintenance of the complex in the coating - 25 wt.%.

On the thus formed covering the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

Example 19. Synthesis of a copolymer of styrene with maleic anhydride and its modification was carried out similarly to example 1. The synthesis of this complex modified copolymer with dimethylallyl(C8-16)benzylammonium was carried out as follows. To 30 ml 6,12% aqueous solution of a copolymer, in which the parts of maleic anhydride modified with the formation of carboxylate groups with vigorous stirring was added to 31.5 ml 14,99% aqueous solution of dimethylallyl(C8-16)benzylaminopurine. There were white precipitate of the complex. This precipitate was washed with water at a temperature of 35-40°C and dried in a vacuum drying Cabinet at 40°C. the Coating on silicate glass formed as described in example 1 from a solution in isopropyl alcohol of a mixture of solutions of this complex (concentration of 5.0 g/DL) and polyvinyl butyral (concentration of 5.1 g/DL) mark "Mowital B60T", which is used for preparation of the coating of example 1. Maintenance of the complex in the coating - 25 wt.%.

On the thus formed covering the growth of fungi according to GOST 9.050-75 missing and not found SOME b is Cheri and mushrooms with 3-fold transmission.

Example 20. Synthesis of a copolymer of styrene with maleic anhydride and its modification was carried out similarly to example 1. The synthesis of this complex modified copolymer with dimethylethylenediamine was carried out as follows. To 9 ml 6,12% aqueous solution of a copolymer, in which the parts of maleic anhydride modified with the formation of carboxylate groups with vigorous stirring was added to 17.8 ml of 7.75% aqueous solution of dimethylethylenediamine. There were white precipitate of the complex. This precipitate was washed with water at a temperature of 35-40°C and dried in a vacuum drying Cabinet at 40°C. the Coating on silicate glass formed as described in example 1 from a solution in isopropyl alcohol mixture solution in the ratio of 1:3 by weight of the complex (concentration of 5.1 g/DL) and polyvinyl butyral (concentration of 5.1 g/DL) mark "Mowital B60T", which is used for preparation of the coating of example 1. Maintenance of the complex in the coating - 25 wt.%.

On the thus formed covering the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

Example 21. A copolymer of styrene with maleic anhydride obtained as described in example 1. A modification of this copolymer was performed with an aqueous solution of potassium hydroxide. To do this in a flat-bottomed flask equipped on the military refrigerator and a magnetic stirrer, download 5,69 g (29,9 mmol-link maleic anhydride) copolymer and at 3.35 g (59,8 mmol) of potassium hydroxide dissolved in 150 ml of water. The process is conducted in a boiling water bath for 2 hours. At the end of the process the whole copolymer is passed into the solution. This modified copolymer was obtained complex with Catalina AB (dimethylallyl(C12-14)benzylammonium). For this to 6.2 g of 50% aqueous solution of catamine AB under vigorous stirring was added to 27.0 ml 4,6% solution of the modified copolymer. There were white resinous precipitate the complex. This precipitate was washed with water and dried in a vacuum drying Cabinet at 40°C. the Coating on the plates of aluminium alloy was formed as described in example 1 from a solution in isopropyl alcohol mixture solution in the ratio of 1:3 by weight of the complex (concentration of 5.2 g/DL) and polyvinyl butyral (concentration of 5.2 g/DL) mark "Mowital B60T", which is used for preparation of the coating of example 1. Maintenance of the complex in the coating - 25 wt.%.

On the thus formed covering the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

Example 22. The coating on the plates of the silicate glass formed from a solution in 2-butanol mixture of solutions in the ratio 1:3 by weight of the complex (concentration of 5.5 g/DL), synthesized as described in example 1, and polyvinyl butyral (concentration of 5.5 g/DL) mark "Mowital B60T", which is used for preparation of the coating of example 1. Maintenance of the complex in the coating - 25 wt.%. The solution was dried in air at a temperature of 40-45°C.

On the thus formed covering the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

Example 23. Synthesis of a copolymer of styrene with maleic anhydride and its modification was carried out similarly to example 1. The synthesis of this complex modified copolymer with dimethylammoniumchloride was carried out as follows. To 44 ml of 8% aqueous solution of dimethylammoniumchloride with vigorous stirring at a temperature of 40-45°C was added 29 ml of 3.6% aqueous solution of a copolymer, in which the parts of maleic anhydride modified with the formation of carboxylate groups. There were white precipitate of the complex. This precipitate was washed with water at a temperature of 40-45°C and dried in a vacuum drying Cabinet at 40°C. the Coating on silicate glass formed as described in example 1 from a solution in isopropyl alcohol of a mixture of solutions of this complex (concentration of 5.8 g/DL) and polyvinyl butyral (concentration of 5.1 g/DL) mark "Mowital B60T", which is used for preparation of the coating of example 1. Maintenance of the complex in the coating - 25 mA is from.%.

This coating is in contrast to a transparent homogeneous coatings formed in examples 1-22, heterogeneous Matt.

Example 24. Synthesis of a copolymer of styrene with maleic anhydride and its modification was carried out similarly to example 1. The synthesis of this complex modified copolymer with dimethylmethyleneammonium was carried out as follows. To 9 ml 6,12% aqueous solution of a copolymer, in which the parts of maleic anhydride modified with the formation of carboxylate groups, with vigorous stirring was added 8 ml of 14% aqueous solution of dimethylbenzylamine. There were white precipitate of the complex. This precipitate was washed with water at a temperature of 35-40°C and dried in a vacuum drying Cabinet at 40°C. the Coating on silicate glass formed as described in example 1 from a solution in isopropyl alcohol mixture solution in the ratio of 1:3 by weight of the complex (concentration of 4.8 g/DL) and polyvinyl butyral (concentration of 4.8 g/DL) mark "Mowital B60T", which is used for preparation of the coating of example 1. Is formed of a transparent homogeneous coating. Maintenance of the complex in the coating - 25 wt.%.

Funginertness cover, GOST 9.050-75 is equal to 3 points. SOME mushrooms this coverage corresponds to 8.4×103and SOME bacteria is 1.2×105.

Thus, the minimum content of the complex Dimity is alkyl(C 8-C16)benzylaminopurine with a copolymer of styrene with maleic anhydride, anhydrous group which is modified with the formation of carboxylate groups in the composition with butyral, providing a complete and prolonged suppression of the growth of microorganisms, ranging from 25 to 50 wt.%. When the contents of this complex in kompoziziii more than 50 wt.% formed sticky waxy coating. When the content of the complex in the composition is less than 25 wt.% not a total prolonged suppression of growth of microorganisms. But even if the contents of this complex in composition of 15 wt.% growth of microorganisms on the coating is lower than in the sample prototype. Complete and prolonged suppression of the growth of microorganisms is achieved by coating composed of complexes of modified copolymers with dimethylammoniumchloride containing alkyl group from C8to C16. The use of complexes with dimethylammoniumchloride, an alkyl group which is shorter than8leads to a decrease in antimicrobial coating properties, incomplete suppression of growth of microorganisms. The use of complexes with dimethylammoniumchloride, an alkyl group which is longer than C16that leads to the formation of heterogeneous opaque covering.

p> The proposed method for the fabrication of polymeric complex has antiseptic properties and antiseptic coating on its basis can be applied for the surface modification of inorganic materials and synthetic polymers with them:

- long-term operation in space objects;

in submarines;

- ground or underground confined spaces;

- in the shops of the net Assembly;

in areas that imposed certain requirements on the microbial load of their surface area - class 100, 10000 and 100000.

A method of manufacturing antiseptic coatings for inorganic materials and synthetic polymers, characterized in that the coating is formed from a mixture of polymeric complex of dimethylammoniumchloride containing alkyl group from C8to C16with a copolymer of styrene with maleic anhydride, previously subjected to chemical modification to the disclosure of anhydrite cycles with the formation of carboxylate groups, butyral when their ratios, wt%:

antiseptic polymer25-50
the butyral50-75



 

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4 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to medicine, namely, to method of obtaining antimicrobial composition for disinfection and sterilisation of products of medical purpose by mixing water base solution, which contains 1-5 wt % of hydrogen peroxide and 5.2-9 wt % of stabilising agent, which represents mixture of aminophosphate, phosphonate and phosphate taken in weight ratio 1:2:4, and solution of activator, containing 40-60 wt % of N-acetyl-caprolactam and 5-15 wt % of morpholine carbonitrile.

EFFECT: terms of storage of ready composition increases to 60 days.

6 cl, 2 tbl, 1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to control of growth of microorganisms in industrial water supply systems. In particular, the invention relates to use of a composition which contains peracetic acid, hydantoin-stabilised halide or a hydantoin-based halide to inhibit growth of microorganisms, especially inhibiting growth of microorganisms and slime deposits in pulp-and-paper mill systems, steel plant and mining industry systems. Compositions used to inhibit growth of microorganisms contain effective amounts of hydantoin or halide of hydrantoin derivatives, a source-donor of halogen and peracetic acid, its derivatives and salts. Methods in which the disclosed compositions are used exhibit synergetic effect of components of the compositions when controlling growth of bacteria, particularly when controlling slime deposition, which lowers concentration of the biocidal compositions used to obtain an efficient result.

EFFECT: wood mass and cellulose obtained using the method for controlling growth of microorganisms in industrial water, as well as paper mass obtained from the wood mass and/or cellulose, treated using the method for controlling growth of microorganisms, are characterised by low total bacterial counts.

20 cl, 3 tbl, 3 ex

Antimicrobial lens // 2434646

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine. Contact lens, which contains, at least, one compound of ionised antimicrobial metal and polymer, obtained from reaction mixture, containing, at least, one hydrophobic component and hydrophilic components in concentration, ensuring hydrophilicity index of, at least, 44.

EFFECT: invention ensures permissible movement on eye in, at least, 90% of patients after, at least, approximately a hour of wearing.

28 cl, 4 tbl, 11 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly product cleaning from prions. A product having an amount of prions is placed in a sterilising chamber. Pressure in the sterilising chamber is decreased to a value below hydrogen peroxide vapour pressure, and a hydrogen peroxide solution is supplied to the sterilising chamber and contacts with the product for prion inactivation on the product.

EFFECT: method provides prion inactivation, especially on medical devices.

13 cl, 4 tbl, 23 dwg

FIELD: medicine.

SUBSTANCE: formulation for producing an antiseptic contains, wt %: manganese chloride - 0.7 % to 1.0 %; potassium iodate - 34.8 % to 42.4 %; potassium chloride - 44.8 % to 54.9 %; sodium dihydrophosphate - 5.6 % to 15.7 %. In the second version of the declared invention, the formulation for preparing the antiseptic contains, wt %: manganese chloride - 0.7 % to 0.9 %; ammonium persulphate - 32.7 % to 39.9 %; potassium chloride - 47.1 % to 57.5 %; sodium dihydrophosphate - 5.0 % to 15.1 %; silver nitrate - 0.4 % to 0.6 %. For preparing a reception of a potassium permanganate solution of the required concentration, said compositions are filled in with a required amount of water. Said compositions can be packed either in sachets in the form mixed powders, or in solid gelatinous capsules to be open before use with the contents poured out in warm water.

EFFECT: extended range of antiseptics combined with higher use reliability and safety.

14 cl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to biotechnology and represents a disinfectant preparation for neutralising spores and vegetative cells Bacillus anthracis, representing an aqueous solution containing mixed bacteriophages Bacillus anthracis OZR-1, Bacillus anthracis F-2, Bacillus anthracis "ФАУТ" in activity relation (PFU/cm3) of Bacillus anthracis OZR-1: Bacillus anthracis F-2: Bacillus anthracis "ФАУТ" = 1: (0.2-1): (0.1-1). and a spore germination activator L-alanine.

EFFECT: invention provides prolonged disinfecting action while being safe.

2 cl, 5 ex

FIELD: medicine.

SUBSTANCE: invention refers to an antimicrobial agent. The antimicrobial agent. A method for prevention or inhibition of growth and/or proliferation of gram-positive bacteria and/or gram-negative bacteria. A substratum which contacts with microorganisms and/or which preferentially shall be free from microorganism accumulation and/or adhesion. Application of the antimicrobial agent. An integrated kit for application in processing a surface of the device with the antimicrobial agent. A method for making the antimicrobial device.

EFFECT: agent exhibits an effective antimicrobial action and can be applied for coating the surfaces and substrata of various devices, such as medical devices and food treatment devices for prevention or accumulation and/or inhibition of growth and/or proliferation and/or viability of microorganisms and/or skinning effect.

13 cl, 20 ex

FIELD: medicine.

SUBSTANCE: invention refers to disinfectants. A tissue used with disinfectant solutions has synthetic fibres and disinfectant release impregnation which make the tissue resistant to an active disinfectant. Particularly, the tissue is resistant when used in disinfectant quaternary ammonium solutions and in disinfectant bleaching solutions. Also, a method of manufacturing such tissue is disclosed.

EFFECT: invention allows making tissue compatible with disinfectant solutions, and especially disinfectant bleaching solutions.

19 cl, 5 tbl, 11 dwg, 7 ex

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention concerns a two-fluid foam for local application on a skin, including from 10 to 98% wt. of a non-polar fluid distinct from fuel, and from 2 to 88% wt of a continuous phase of the polar fluid including C1-C4 alcohol, liquid polyethylene alcohol, ethylene alcohol or propylene glycol, or their admixtures, in quantity of at least 65% wt concerning mass of a continuous phase where the two-fluid foam is stabilised by surface-active substance in quantity from 0.05% to 2% wt in reliance on all composition which is chosen from adducts castor oil/poly (alkylene glycol), containing from 20 to 50 alkoxy groups, C8-C24 fatty acid or adducts the hydrogenated castor oil/poly (alkylene glycol), containing from 20 to 60 alkoxy groups, or from their admixtures. The stable dispersion having content of C1-C4 of alcohol, liquid polyethyleneglycol, ethyleneglycol or glycol propylene, at least 65% wt, and including from 1 to 80% wt of a two-fluid foam and from 99 to 20% wt of water gel.

EFFECT: received compositions include high content of alcohol for medical and cosmetic use.

19 cl, 28 ex

FIELD: medicine, virology, pharmacy.

SUBSTANCE: invention relates to using derivatives of dithiocarbamate of the formula: R1R2NCS2H and oxidized forms of these compounds, in particular, their dimmers and their pharmaceutically compatible salts for preparing an agent used in treatment or prophylaxis of infection caused by RNA-containing viruses that damage respiratory tract and inducing disease. Also, invention relates to a disinfecting agent containing dithiocarbamate compound and a method for disinfection of surfaces, media and cell cultures.

EFFECT: valuable medicinal properties of compounds.

19 cl, 14 dwg, 14 ex

FIELD: medicine, virology, pharmacy.

SUBSTANCE: invention relates to using derivatives of dithiocarbamate of the formula: R1R2NCS2H and oxidized forms of these compounds, in particular, their dimmers and their pharmaceutically compatible salts for preparing an agent used in treatment or prophylaxis of infection caused by RNA-containing viruses that damage respiratory tract and inducing disease. Also, invention relates to a disinfecting agent containing dithiocarbamate compound and a method for disinfection of surfaces, media and cell cultures.

EFFECT: valuable medicinal properties of compounds.

19 cl, 14 dwg, 14 ex

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention concerns a two-fluid foam for local application on a skin, including from 10 to 98% wt. of a non-polar fluid distinct from fuel, and from 2 to 88% wt of a continuous phase of the polar fluid including C1-C4 alcohol, liquid polyethylene alcohol, ethylene alcohol or propylene glycol, or their admixtures, in quantity of at least 65% wt concerning mass of a continuous phase where the two-fluid foam is stabilised by surface-active substance in quantity from 0.05% to 2% wt in reliance on all composition which is chosen from adducts castor oil/poly (alkylene glycol), containing from 20 to 50 alkoxy groups, C8-C24 fatty acid or adducts the hydrogenated castor oil/poly (alkylene glycol), containing from 20 to 60 alkoxy groups, or from their admixtures. The stable dispersion having content of C1-C4 of alcohol, liquid polyethyleneglycol, ethyleneglycol or glycol propylene, at least 65% wt, and including from 1 to 80% wt of a two-fluid foam and from 99 to 20% wt of water gel.

EFFECT: received compositions include high content of alcohol for medical and cosmetic use.

19 cl, 28 ex

FIELD: medicine.

SUBSTANCE: invention refers to disinfectants. A tissue used with disinfectant solutions has synthetic fibres and disinfectant release impregnation which make the tissue resistant to an active disinfectant. Particularly, the tissue is resistant when used in disinfectant quaternary ammonium solutions and in disinfectant bleaching solutions. Also, a method of manufacturing such tissue is disclosed.

EFFECT: invention allows making tissue compatible with disinfectant solutions, and especially disinfectant bleaching solutions.

19 cl, 5 tbl, 11 dwg, 7 ex

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