Method for morphologic prediction of children arachnoid brain cyst progression
SUBSTANCE: histologic examination of transverse section is performed through all the layers of arachnoid cyst walls with previous alignment of the piece in paraffin on the edge and study the state of lining and connective-tissue membrane. In case the wall of the cyst is covered in flat arachnoendothelium with hyperchromatic nucleus, the cyst is regarded the non-proliferating, the prognosis is favorable. In case the wall of the cyst is covered with round-shaped arachnoidendothelium with the zones of amplified proliferation of arachnoidendothelium in form of multirowed layer and/or vertical cells alignment, it is regarded as proliferating - the prognosis is unfavorable.
EFFECT: morphologic prediction of children arachnoid brain cyst progression.
1 dwg, 2 dwg, 1 tbl, 2 ex
The invention relates to medicine and can be used in forecasting the development of the clinical course and outcomes of surgical treatment arachnoidal cysts of the brain in children.
Possibilities of modern medicine and new ways of treatment (endoscopic surgery), as well as the introduction of new technologies in neurosurgery poses new challenges for morphologists, requires a deeper analysis of histostructure and evaluate the value of the morphological and functional transformations arachnoidal cysts for prediction of clinical course of the disease.
Normal arachnoidea shell consists of three layers - an inner arachnoidal layer, collagenolytic basics and outer arachnodactyly layer, also describes the expansion of the outer arachnodactyly layer normal arachnoid (Dobrovolsky GF ABOUT the role of the ultrastructure of the arachnoid of the human brain in the process of removal of erythrocytes subarachnoid streamed blood. - Matters. on neurosurgery. - 1974. No. 2. - P.32-37; Dobrovolsky GF / Ultrastructure of cell spots arachnoid brain of man (Genesis arachnoentomology of ottsepleny hard shell of the brain) // Questions of neurosurgery. - 1976. No. 4. P.47 - 53).
It is proved that cells arachnodactyly secreting have abilities that can affect the increase in the volume of the cyst (Go, K.G. Houthoff H.J Blaauw E.H et al. Arachnoid cysts of the sylvian fissure. Evidense of fluid secretion // J neurosurg. - 1984. - Vol.60. - P.803-813).
The known method pathological studies arachnoidal cysts, which were studied drugs brain two deceased patients by the arachnoid cysts. It is noted that the inner wall of the cyst adjacent to the brain, goes directly to the outside. Under the internal wall of the cyst is determined by the subarachnoid space. Thus, the cavity arachnoidal cysts limited duplicatory of the arachnoid. In addition, in the study of outer wall arachnoidal cysts revealed the presence of foci of proliferation (previously named Dobrovolsky GF cell spots) and the identification of blood capillaries that are absent in normal arachnoid membrane. But not assessed the effects of these findings in the clinical course arachnoidal cysts. (Gradirovskii, Tambient, Niihin et al. Arachnoidal cysts (postmortem examination). - // Ukr. neurol. and the psychiatrist. imasco. - 1990. - T. No. 10. - P.20-25).
The known method of histological examination in the outer wall of the cyst fibrous fibrous layer, which is highly developed, which is regarded as a cause of decompensation process and is a nonspecific response to stretching (Muhametzhanov X., Ivakina NI VRO is established intracranial arachnoidal cysts in children. - Alma-ATA, 1995. - S-134). In the way that no attention is paid to clinical and morphological comparisons, the effects of the characteristics of the functional state of the lining of the cyst on the development of clinical course and prognosis of this disease.
Methods of predicting the course of disease depending on morphological variant arachnoidal cysts are absent.
The invention is directed to a method of in vivo morphological predicting the course arachnoidal cysts of the brain in children.
This technical result in the implementation of the invention is achieved by the fact that the morphological method of predicting the course of arachnoidal cysts of the brain in children peculiarity lies in the fact that conduct histological examination of transverse sections through all layers of the wall arachnoidal cysts with a preliminary orientation of the piece on "the edge" and assess the condition of pavements and connective tissue membrane. If the cyst wall is covered with flattened arachnodactyly with hyperchromic nuclei, the cyst is referred to nephrolithotripsy - the prognosis is favorable, but if the cyst wall is covered with arachnodactyly, round shaped zones of proliferation of arachnodactyly in the form of the multiple layers and/or vertical arrangement of cells, it belongs to the cast new Araruama - the prognosis is poor.
The method is as follows.
The fence of the operational material then leaves the outer and inner walls arachnoidal cysts are immersed in different containers with saline 0.9% solution of sodium chloride and mark.
Preparation for commit - outer and inner wall arachnoidal cysts straighten and spread out on sheets of cardboard or paper outer surface up to the best of unfolding the cyst wall, which is necessary for accurate verification of the structures of its walls. Pieces fix bandages.
Fixation of drugs is carried out in 10% formalin not later than three hours after sampling to prevent autolytic processes. The material is carried out in alcohols by standard procedures. Then make the fill of drugs in paraffin in position "on the edge" for surveillance cross section and all layers of the cyst wall.
Histological study was conducted using dyed with hematoxylin and eosin according to van Gison, Ft to assess the condition of pavements arachnoidal of the cyst and its connective tissue membrane.
In preparations stained with hematoxylin and eosin, and studied the state arachnodactyly lining of the cyst. In preparations stained by van Gison, appreciate groovology what's connective tissue fibers in the wall of the cyst. On drugs, imprisioned method M, estimate the number of vessels and the presence of foci of angiomatosis in connective tissue membrane. If the wall arachnoidal cysts covered with a layer of flattened arachnodactyly with hyperchromic nuclei, the cyst is referred to nephrolithotripsy (Figure 1), if the cyst wall is covered with arachnodactyly, round shaped with zones of enhanced proliferation of arachnodactyly in the form of multi-layers (arachnodactyly kidney) and/or vertical arrangement of cells, the cyst is referred to as proliferating (Figure 2). If the cyst nephrolithotripsy - positive Outlook (uncomplicated clinical course of the disease), and if proliferating - the prognosis is poor (complicated, relapsing course of the disease).
The inventive method morphological predicting the course arachnoidal cysts of the brain in children was developed and clinically tested in the Polenov research neurosurgical Institute imageline the clinical-morphological study of 37 patients with by the arachnoid cysts of the brain.
In the study of complicated clinical course arachnoidal cysts in different functional groups revealed that this clinical course is typical of proliferating cysts at the level of statistical significance of difference p<0,01. The results of the research the Finance presented in the table.
|Complicated clinical course depending on the functional group arachnoidal cysts (n=37)|
|Functional group arachnoidal cysts||Clinical course arachnoidal cysts||Only|
In the study of repeated interventions, due to complications and recurrence of the disease in different functional groups, it was found that in the group proliferating arachnoidal cysts often produced re-intervention at the level of statistical significance of difference p<0,01. While subsequent operations were carried out with the extension of its area of intervention, in the beam of the presence of epileptic syndrome of repeated surgical intervention was supplemented by resection of the epileptic focus, and in cases of hypertensive symptoms was performed a wide excision of the walls and the creation of anastomoses with the basal cisterns.
Examples of extracts from the histories.
Example 1. B-Naya K., age 15, IB. 713-99, suffered from the age of 7, when there are headaches with nausea, radiating to the left eyeball, and the deviation of the left eyeball medially, difficulty in understanding speech, irritability, neurologist prescribed dehydration and vascular therapy without effect, for the year prior to surgery headaches intensified, joined vomiting, CT scan revealed a cyst of the left pole of the temporal lobe dimensions of 2.5×3 cm, the patient was admitted to hospital for surgical treatment. Operation was performed - osteoplastic trepanation in the left temporal region - excision of the outer cyst wall. According to the claimed method was conducted histological examination. Wall arachnoidal cyst was covered with one layer of flattened arachnodactyly with hyperchromic nuclei, identified nephrolithotripsy arachnoidal cyst, on the basis of which he was made a favorable prognosis. Indeed, after 8 years after surgery, the child has graduated from secondary school, re-operation was not performed, socially adapted, no complaints.
Example 2. B-Neu Century, 15 years old, IB. 194-94, more than the t to 14 years, when did the headaches. Using CT detected arachnoidal cyst in the right temporal and frontal lobe size of 5.5×6 cm, in the dynamics of a detected displacement of the midline structures to the right to the left 6 mm, neurological symptoms presented left-sided pyramid failure, narrowing of the right eye slits. Operation was performed - osteoplastic trepanation in the right fronto-temporal region - partial excision of the outer cyst wall. According to the claimed method was conducted histological examination walls arachnoidal cysts. It is revealed that the wall is covered by arachnodactyly rounded with numerous foci of proliferation of arachnodactyly, connective tissue membrane had lots of different thickness with different density and arrangement of collagen fibers, with a significant number of vessels. Installed proliferating arachnoidal cyst, made a poor prognosis. The postoperative course was hard, with a complication in the form of hemorrhage into the cyst cavity, requiring repeated surgical intervention.
The morphological method of predicting the course of arachnoidal cysts of the brain in children, characterized in that conduct a histological study of transverse cut through all layers of the wall of arachno the long-cyst with a preliminary orientation of the piece on "the edge" and assess the condition of pavements and connective tissue membrane, if the cyst wall is covered with flattened arachnodactyly with hyperchromic nuclei, the cyst is referred to nephrolithotripsy - the prognosis is favorable, but if the cyst wall is covered with arachnodactyly, round shaped with zones of enhanced proliferation of arachnodactyly in the form of the multiple layers and/or vertical arrangement of cells, it is referred to proliferating - the prognosis is poor.
SUBSTANCE: invention relates to field of medicine, namely to hepathology and pediatrics. In order to predict exacerbations of chronic viral hepatitis B in teenagers, blood test is performed. By means of bioluminescent method determined is activity of lymphocyte enzymes in peripheral blood of patients: glucose-6-phosphate dehydrogenase (G6PDG) and lactate dehydrogenase (NADN-LDG), ratio of activities is calculated. If value of obtained index is equal or is higher than 1.15 exacerbations are predicted, if index value is lower than 1.15, absence of exacerbations is predicted.
EFFECT: method makes it possible to predict exacerbations of chronic viral hepatitis B in teenagers with clinical-biochemical remission with high accuracy.
4 ex, 2 tbl
SUBSTANCE: formation of a risk group of neoplastic disorders in a cervical epithelium is carried out by IF staining of a cervical epithelium smear with using a monoclonal antibody reacting with a sialylated conformational glycopeptide antigen determinant as a part of MUC1 followed by with cell finish staining with chromogenic nuclear stain. The sample is examined by alternated fluorescent light and transmission light. Each cell with a depolarised stained surface membrane detected by fluorescent light is examined in transmission light. If the cells with the depolarised stained surface membrane detected by fluorescent light show cytological symptoms of dyscariosis, and/or proliferative parabasal cell complexes with no symptoms of dyscariosis show depolarised stained surface membranes or granular stained cytoplasm, a patient is subsumed to the risk group of the presence of neoplastic disorders in the cervical epithelium.
EFFECT: higher analysis accuracy.
SUBSTANCE: LAKK-02 apparatus is used to evaluate a capillary blood flow reserve in two iontophoresis sampled taken from skin of a left forearm in a point along a median line 4 cm higher than styloid process of ulna and radius. An endothelial function coefficient EFC is calculated by formula: where AC BFR is the capillary blood flow reserve in response to acertylcholine; SN BFR is the capillary blood flow reserve in response to sodium nitroprusside. If the EFC value is lower than 1.0, a disturbed microvascular endothelium vasoregulation is stated.
EFFECT: use of the invention allows simplifying diagnostics of the microvascular endothelium status in patients with bronchial asthma.
SUBSTANCE: biopsy materials of a mucous membrane of a gastric corpus and a duodenum are analysed for mast cell count per 100 cells of infiltrate. At detecting more than 3.5 mast cells per 100 infiltrate cells in the biopsy materials of the mucous membrane of the gastric corpus and more than 4.75 cells per 100 infiltrate cells in the biopsy materials of the mucous membrane of the descending duodenum, immunohistochemistry or PCR diagnostics are required. If detecting Epstein-Barr virus antigens or DNA in the biopsy materials of the gastric and duodenal mucosa, EBV associated gastroduodenitis is diagnosed.
EFFECT: use of the technique allows diagnosing EBV associated gastroduodenitis in children.
SUBSTANCE: invention describes method of noninvasive potentiometric determination of oxidant/antioxidant activity of biological tissues, which includes bringing analysed object in contact with electroconductive medium, which containing mediator system and estimation of oxidant/antioxidant activity by change of potential difference on electrodes, introduced into electroconductive medium, and electroconductive medium represents gel, which contains as mediator system a pair of chemical compounds, containing element in different degrees of oxidation, electrodes through gel contact with the analysed object, and oxidant/antioxidant activity is determined by formulae. For realisation of method claimed is device, which includes apparatus for measuring potential difference and filled with electroconductive medium reservoir with working electrode and electrode of comparison, connected with device for measuring potential difference, where reservoir is made open from one side. As electroconductive medium applied is gel, and working electrode is made in form of plate, placed from the side of open part of reservoir and partially covering it.
EFFECT: increase of reliability and accuracy of obtained results.
4 cl, 5 ex, 6 dwg
SUBSTANCE: light flux power passed though biological tissue specimen is measured in photometric chamber at two different flux reception aperture. Note here that, first, diaphragm is used to limit flow diameter to that equal to diameter d of specimen illuminating beam. Then, said diameter is increased to diameter D 5 to 10 times greater than first diameter d. Dissipation and absorption factors s and a are defined from formulas, respectively: s = p∂+τ∂ and a = 1 - s - τd, where τd is directed transmission factor defined as τd=Fτd/F0, F0 is initial power of illuminating beam, (mW), Fτd is measured power of transmitted flux with diaphragm d, τ∂ is diffusion transmission factor defines as: τ∂ =τ -τd, where τ is total (integral) transmission factor defined as τ=Fτ/F0, where Fτ is measured power of transmitted flux, (mW), with diaphragm D, ρ∂ is back scatter factor defined from for photometric invariant
EFFECT: high accuracy.
1 ex, 1 dwg
SUBSTANCE: stool consistency and urine acidity are determined. Stool type is estimated by Bristol scale. Diet is administered. When stool type 5 or 6 by Bristol scale and alkaline urine reaction are achieved, conclusion about sufficient content of dietary fibres in diet is made.
EFFECT: method makes it possible to establish individual need in dietary fibres.
SUBSTANCE: invention refers to a diagnostic technique for chronic tonsillitis (CT). A patient is examined for a complex of intestinal mirobiocenosis indicators: the content of bifidus bacterium, lactic acid bacillus, normal coli bacillus, hemolytic coli bacillus, lactose-negative coli bacillus, enterococcus, staphylococcus saprophyticus, staphylococcus aureus, Candida fungus to be compared with the reference values by a score scale. A dysbiosis index is calculated by formula: where DI is the dysbiosis index, I1 I2…In are the evaluated intestinal mirobiocenosis indicators, n is a number of the evaluated indicators. If the dysbiosis index is 0 to 0.73±0.07, a compensated form of the disease is diagnosed in a patient with local signs of CT. If the dysbiosis index is 0.89±0.11 and higher, a decompensated form of CT is stated.
EFFECT: use of the method enables diagnosing the compensated and decompensated forms of CT, specifying a further therapeutic approach, detecting indications and contra-indications to surgical intervention, prescribing an adequate antibacterial therapy and carrying out preventive measures.
2 tbl, 3 ex
SUBSTANCE: blood serum is analysed for a creatinine level, glomerular filtration rate is evaluated by MDRD formula, relative urine density is determined, then a maximum thickness of renal parenchyma, systolic and diastolic blood pressure are measured. Further, the presence of sclerosis is calculated by formula:
, where S is an index of renal glomerule sclerosis, K is glomerular filtration rate calculated by MDRD method (ml/min/1.73 m2), O is a relative morning urine density, T is the greatest thickness of renal parenchyma determined by ultrasound data (mm), C is systolic blood pressure (mm Hg), D is diastolic blood pressure (mm Hg). If S <10, the absence of glomerule sclerosis is diagnosed, and if the values S≥10.1 shows the presence of nephritic tissue sclerosis. The method can be used in initial diagnosing of glomerulosclerosis in the patients with diffuse renal diseases.
EFFECT: use of the method provides noninvasive diagnostics of renal sclerosis in glomerulopathies.
3 ex, 2 tbl
SUBSTANCE: invention can be used: in medicine, in studying the diseases associated with inflammations, cell respiration disturbance, protein decomposition, in pharmacology, for detecting the iatrogenic diseases caused by various fillers, in biophysics (magnetobiology), for interpreting a mechanism of biomedical effect produced by electromagnetic fields in a human body, in mineralogy whereas considerably expanding temperature barometric, time and oxidation-reduction limits of oxide and sulphide mineral formation, in biochemistry, colloidal chemistry etc. The use of an ultrathin tissue section prepared for electron microscopy enables mineral grain analysis by electronic microdiffractometry.
EFFECT: higher reliability of the phase analysis.
2 ex, 6 dwg
SUBSTANCE: during hospitalization the patient plasma is examined using the cuneal dehydration: the plasma drop is dried on the slide and then the resulting facia is subject to microscopic analysis. With combination of two signs present - net of cracks in peripheral area of facia and dendritic crystals branching at the angle 60 or 90 degrees in central zone or the presence of “double facia” phenomenon the conclusion is made on maximal possibility of acute pancreatitis lethal outcome.
EFFECT: enhanced selection of patients with acute pancreatitis of severe aggressive character and serious prognosis.
1 dwg, 2 ex, 2 dwg
SUBSTANCE: after liver resection in patients with colorectal metastases the determination is performed for degree of metastases differentiation and expressin CK 20, β-cat, Ki 67 Max, wherein for β-cat nuclear expression is also defined, and for Ki 67 Max - proliferation index ≤30% or >30%, then using the Molecular Factors table contained in the description, depending on the type of differentiation degree the significance levels of detected factors are determined, the resulting points are summed, then the prediction of relapse free survival P(M) is made using formula and with P(M) of 100-66 points the relapse less survivability prognosis is poor, the risk of relapse development is predicted within 12 months, with 65-40 pints the prognosis is moderate, risk of relapse development is within 12-23.9 months, with 39-10 points - the prognosis is good, the relapse development risk is either absent or is predicted after 24 months.
EFFECT: precision of prognosis of disease relapse after liver resection regarding metastatic colorectal cancer.
1 dwg, 2 tbl, 2 ex
SUBSTANCE: the method of diagnostics involves determination of vasculoendotelial factor in the patient urine and with its value above 140 pg/ml the damage of renal parenchyma is diagnosed.
EFFECT: method is non-invasive, more precise and simple compared with other renal parenchyma damage diagnostics methods.
1 dwg, 3 ex, 1 tbl
SUBSTANCE: method involves defining induced and spontaneous platelets aggregation in the blood serum sample. The inductor used is adenosine diphosphate (ADP) in concentration 1.25 μg/ml. In patients with the hepatic cirrhosis of viral origin during induced aggregation the size of aggregates is 0.85-1.1 CU; size during spontaneous aggregation is 0.20-0.57 CU. In patients with the hepatic cirrhosis of alcohol origin during induced aggregation the size of aggregates is 0.69-0.84 CU; size during spontaneous aggregation is 0.58-0.7 CU. In patients with the hepatic cirrhosis of mixed origin (viral-alcohol) during induced aggregation the size of aggregates is more than 1.1 CU; size during spontaneous aggregation is more than 0.7 CU.
EFFECT: increased precision and information content of hepatic damage etiology in patients with cirrhosis that allows doctor detect and take into account two pathologic factors present in the patients.
1 dwg, 3 ex, 1 tbl
SUBSTANCE: method comprises the definition of secretor IgA in saliva before diagnostic elimination test and on day 4-5 of test, and going by alteration of its parameter (towards increase or decrease) by more than 30% food allergy is diagnosed.
EFFECT: effective and safe diagnostics of children food allergy, including clinical significance of suspected food allergen for the body and provides for timely defining on pathogenic therapy tactics.
1 dwg, 1 tbl, 1 ex
SUBSTANCE: invention refers to medicine particularly to allergology and pulmonology and can be used in differential diagnostics of bronchial asthma (BA) - atopic asthma (AA), asthmatic triad (AT) and incipience of chronic obstructive lung disease (COLD). For this purpose respiratory function is checked of a patient and Tiffeneau index is defined. Then cytokines IL-4 and IL-8 concentration in periferic blood and antioxidant transferrin are defined. Further the mathematical model including the examined indexes is made and complex mathematic performance evaluation. On the first stage the regressive function is calculated according to the formula f COLD/BA = 4.1609+ a*(-5.787)+b*(-0.062)+c*(0.01308)+d*(-0.1025) where Tiffeneau index (1 - value >70% of the due values, 0 - value <70% of the due values); b content IL-4 (equivalent units); c content IL-8 (equivalent units); d - transferrin content (equivalent units). Then the potential is calculated in respect to according to the formular P COLD/BA =1/(1+y -fCOLD/BA ) where P COLD/BA is potential COLD occurrence in respect to BA; e=2.718 is the base of the natural logarithm. With P COLD/BA ≥0.5 the probability of COLD occurrence is higher in respect to BA - in this case COLD is diagnosed. If P COLD/BA <0.5 the probability of BA occurrence is higher in respect to COLD. In this case pass to the second stage when the regressive function is calculated according to the formula F AT/AA =-21.847+a*(26.607)+b*(-0.2227)+c*(0.1)+d*(-0.304). After this the probability of AT occurrence in respect to AA is calculated according to the formula PAT/AA =1/(1+e -1AT/AA ) where PAT/AA is the probability of At occurrence in respect to AA. With PAT/AA ≥0.5 the probability of AT occurrence is higher in respect to AA then AT is diagnosed. If P PAT/AA <0.5 the probability of AA occurrence is higher in respect to AT then AA is diagnosed.
EFFECT: means provides timely effective differential diagnostics of bronchial asthma clinico-pathogenetic variants and incipience of COLD for timely pathogenetic treatment of such diseases.
3 ex, 1 dwg
SUBSTANCE: invention relates to medicine, namely, gynecology and obstetrics, and relates to a method of forecasting the formation of feto-placental insufficiency in patients with threatening miscarriage in the first trimester of pregnancy. The essence of the method is in calculating leukocyte index of intoxication on the basis of the received common blood test and evaluates its performance in early pregnancy. If the value of leukocyte index of intoxication from 1.5 to 3.0, then predict the formation of feto-placental insufficiency.
EFFECT: using the method allows to predict the formation of feto-placental insufficiency in patients with threatening miscarriage in the first trimester of pregnancy with high accuracy.
4 ex, 1 dwg
SUBSTANCE: system for measuring the concentration of the analyze in a sample of body fluid includes: toner supplies, storage media attached to the cartridge and contains calibration information for supplies, portable device and attached to the cartridge and removable storage unit that stores more data. Portable device comprises: receiving compartment, cartridge reader, load-transfer device for moving supplies cartridge, the chip-measuring device, memory connected to the processor and containing the software and interface for additional data from a removable storage unit data to a portable device. Additional data are used in combination with the calibration information in the analysis of the measurement signal. The processor provides check on the coincidence of calibration data with additional data storage unit during replacement and introduction the cartridge and the formation of a indicate signal for user, whether the supplies, along with additional information sufficient to perform reliable measurements or not. The group present invention also relates to the cartridge unit with storage for a portable instrument for measuring the concentration of an analyte in a sample of body fluid.
EFFECT: group of inventions provides accurate measurement of the concentration of an analyte in a sample of body fluid with the lowest cost.
13 cl, 5 dwg
SUBSTANCE: essence of the method for determining the indication for antioxidant therapy in the treatment of inflammatory diseases of the internal female reproductive organs is in determination of the source and target, respectively, that describe the values of parameters of free radical processes in the patient's body, namely, spontaneous luminosity of the sample (SLS), the height of the slow flash (HSF), visible flare light sum (FSS). The reference value for each indicator compared to the initial value of the same indicator. When the relative rates of initial control values SLS - 40% or more of HSF - a 35% or more, FSS - by 20% or more, antioxidant therapy is necessary.
EFFECT: using this method allows improving the reliability determination of the antioxidant therapy indicator in the treatment of the internal female genital organs inflammatory diseases.
2 ex, 1 dwg
SUBSTANCE: method for evaluation of patients with pancreatic postnekrotic states by examining the patient's blood. Lymphocyte subpopulation is determined by flow cytometry method, calculate the ratio CD3+ 4+ T-helper to CD3+ 8+ - cytotoxic lymphocytes (immunoregulatory index) and with the level of 0.5-0.3 consider the patient's condition as serious.
EFFECT: evaluation of patients with pancreatic postnekrotic states by examining the patient's blood.
2 ex, 1 dwg
FIELD: medicine, psychiatry.
SUBSTANCE: one should isolate DNA out of lymphocytes of peripheral venous blood, then due to the method of polymerase chain reaction of DNA synthesis one should amplify the fragments of hSERT locus of serotonin carrier gene and at detecting genotype 12/10 one should predict the risk for the development of hallucino-delirious forms of psychoses of cerebro-atherosclerotic genesis.
EFFECT: more objective prediction of disease development.