The composition possessing antimicrobic activity containing bispyridinealkane (octenidin dihydrochlorid)

FIELD: medicine.

SUBSTANCE: group of inventions refers in particular to solutions for mouth rinsing. The water based composition possessing antimicrobic activity consists of: a) from 0,001 to 10 % of weight octenidin dihydrochlorid b) from 0,05 to 30 % of weight of not ionic surface-active substance - derivative fat acids, c) from 0,01 to 10 % of weight poliol, chosen from 1,2-propylene glycol, 1,3 propylene glycol, butane-1,4-diol, sorbite (hexa-1,2,3,4,5,6-hexole) and glycerin or their mix, d) from 0,05 to 10 % of weight of fruit acid and-or its salt chosen from lemon acid, dairy acid, apple acid, wine acid, glycogenic acids, fumaric and amber acid or their mix, e) from 0,025 to 10 % of weight of flavour and-or sweetener, chosen from alitam, aspartame, dulcin, neohesperidin DC, stevioside, sucralose, suosane and thaumatinor their mixtures with water - up to 100 %. The composition is applied as a solution for mouth rinsing and controlling S. Aureus and/or E. faecalis resistant to methicillin.

EFFECT: invention provides efficiency of application as the solution for mouth rinsing awhich is characterized by pleasant taste and a small tendency to foaming.

11 cl, 2 ex

 

The present invention relates to possess antimicrobial activity of the composition is water-based, which includes bipyridinium, as well as to the use of a composition as a solution for mouthwash or oral antiseptic.

There are a number of solutions for rinsing the mouth on the basis of various active compounds, which have inherent weaknesses. For example, the active compound chlorhexidine used in solutions for rinsing the mouth, in the case of long-term use can cause side effects such as black and brown staining of the teeth, plastic seals and the rear part of the language that need to be deleted conducted by professional mechanical tooth cleaning. Moreover, there may be a violation of taste perception, desquamation and damage to the mucous membrane of the mouth. Also described barriers to the healing of wounds after direct application after the operation.

In addition, reported cases of anaphylactic reactions and hypersensitivity. The period of application of chlorhexidine should not exceed 14 days because of known side effects.

Moreover, the known oral antiseptics on the basis of polyvinylpyrrolidone-iodine (PVP-iodine). When using protein can affect their activity. In addition, the pigment component of the product causes the singing is of stains on textiles. In addition, the product has a residual activity from weak to absent, and there is resorption of iodine or iodide. The contraindications that prevent the use of oral antiseptics on the basis of PVP-iodine, are thyroid disease, pregnancy and lactation, and also known sensitivity to iodine.

In the case of products on the basis of hexetidine can meet hypersensitivity reactions. In addition, hexetidine is a releasing formaldehyde compound, which causes concern because of its toxicity.

According to the prior art, moreover, as the active connection solutions for rinsing the mouth known triclosan, which causes the resistance to essential medicines (see C. Rungtip, K. Beinlich, T. T. Hoang, A., Becher, R. R. Karkhoff-Schweizer, H. P. Schweizer, Cross-Resistance between Triclosan and Antibiotics in Pseudomonas aeruginosa is Mediated by Multidrug Efflux Pumps: Exposure of a Susceptible Mutant Strain to Triclosan Selects nfxB Mutants Overexpressing MexCD-OprJ, Antimicrob. Agents and Chemother. 45 (2001) 428-432).

In addition, oral antiseptics on the basis of active compounds thymol, eucalyptol and menthol, which is a concern because of its toxicity, because they are phenolic compounds.

It also describes the use of compositions containing bipyridinium (for example, the dihydrochloride of N,N'-(1,10-decandiol-di-1-[4H]-pyridine is l-4-ilidene)-bis(1-octamine) (hereinafter actinidin)). Actinidin is bipyridinium with the following Mazomanie boundary patterns:

For example, in US-A-4206215 described that bipyridinium can be used as antimicrobial agents and, in particular, as agents for the care of teeth, inhibiting the formation of dental stains. WO 02/02128 reveals local oral composition for rehabilitation, which may include actinidin. EP-A2-0252278 discloses a disinfectant and its application for disinfection of skin and mucous membranes. Composition of the disinfectant based on alcohol, hydrogen peroxide or compounds which form hydrogen peroxide in the aqueous phase, and may contain actinidin.

EP-A1-0411315 discloses aqueous antiseptic composition as an antiseptic for the mouth and for the treatment of wounds, which contains octenidine the dihydrochloride, as well as Phenoxyethanol and/or phenoxypropanol in certain quantities. Illustrative compositions contain cocamidopropylbetaine ((3-cocoamidopropyl)dimethylethanolamine), which leads to strong foam formation, which is undesirable in the case of solutions for rinsing the mouth, or large quantities of fatty alcohols and silicone oil, which due to unpleasant oily taste poorly suited for use in the oral cavity.

<> US 2006/0051385 Α1 relates to cationic antiseptic compositions and their use. The composition may contain actinidin in accordance with the General disclosure. Specific guidance on how it can be composed of the composition of the solutions for rinsing the mouth, contains actinidin cannot be obtained from open document, and such indication is also not disclosed in the examples.

Actinidin, in addition, has been used successfully for many years in antiseptic applicant Octenisept® mucous and treatment of wounds. Disadvantages are the bitter taste and foaming commercial product when rinsing the mouth or throat that worsens its applicability as a solution for rinsing the mouth.

Accordingly, the object of the invention is to provide a composition that does not have the described disadvantages of the known prior art. In particular, it is necessary to provide a composition that

has enough flavor neutral or has a pleasant taste, that is, for example, has no bitter taste, octenidine,

does not foam when rinsing the mouth,

at low concentrations of active compound or active compounds is quite active against a broad spectrum of microorganisms, in particular, is active against methicillin-resistant species type Staphylococcus aureus and Enterococcus faecais, and

toxicologically harmless, even when applied over a relatively long period of time.

Unexpectedly found that this object is achieved with the antimicrobial activity of the composition is water-based, which includes

a) from 0.001 to 10% by weight piperidinyloxy,

b) from 0.05 to 30% by weight non-ionic surfactants,

c) from 0 to 40% by weight aromatic alcohol and

d) from 0.01 to 10% by weight of a polyol selected from alkanediols and Alcantara.

Additional optional components include

e) fruit acid and/or its salt,

f) the flavorings and/or sweeteners and/or

g) acid, base and/or buffer.

The invention is based, inter alia, established by the authors of the fact that through the use of Nevinny surface-active substances that do not adversely affect the activity piperidinyloxy, the result is a composition that does not foam at the mouth rinse and has a neutral taste. In addition, flavorings, which additionally contribute to a pleasant taste, it is better soluble in the compositions according to the invention. In addition, compositions of the invention possess very high activity against all organisms, which are oral antiseptics, and solutions for rinsing the mouth, simultaneously with vastmajority compatibility and portability. For example, from the examples, a composition of the invention containing the active compound of actinidin in the amount of about 0.1% by weight, are more active than a commercial product Chlorhexamed forte®, containing 0.2% by weight of chlorhexidine digluconate as the active connection.

a)Bipyridinium

Compositions of the invention contain at least one bipyridinium. The expression "bipyridinium includes bis[4-(substituted-amino)-1-pyridine]alkanes disclosed in DE 2708331 C2 and DE 10205883 A1. While all allegations of piperidinyloxy applicable to the entire class of substances, they are applicable, in particular, to octenidine, which is preferred in all embodiments of the invention.

Especially preferably actinidin used as component a).

The preferred concentration of the component a) is from 0.01 to 1% by weight, preferably from 0.03 to 0.5% by weight, more preferably from 0.05 to 0.2% by weight, in particular from 0.08 to 0.12% by weight, for example, 0.1% by mass.

b)Non-ionic surface-active agent

Preferred nonionic surfactants that can be used in the compositions according to the invention is selected from polyalkoxy fatty alcohols, esters sorbitan with fatty acids and esters of polyoxyethylenesorbitan with IRN the mi acids, Alkylglucoside and monoglycerides alkoxysilane (in particular, ethoxylated) fatty acids and a monoglyceride of a fatty acid, a substituted 5-100-ethoxypropane is preferred, in particular the monoglyceride of a fatty acid, a substituted 20-70 ethoxypropane, such as, for example, substituted approximately 40 ethoxypropane (i.e. macrogolglycerol hydrastart containing 40 ethylenoxide links, which is available under the name Eumulgin HRE 40 PH® from Cognis and Cremophor RH 40® from BASF).

Polyalkoxy alcohols also include alkoxylated fatty alcohols, such as isabellejosepht containing various percentages of ethylene oxide, isotridecanol, ethers of polyethylene glycol and stearyl, lauric, cetyl and olejowego alcohol. The alcohols can be alkoxycarbonyl with ethylene oxide, propylene oxide or any desired mixture of ethylene oxide and propylene oxide. Polyalkoxy alcohols are known, inter alia, under the name Lutensol®, Marlipal®, Marlox®, Brij®, Plurafac®.

In addition, as non-ionic surfactants used esters sorbitan, usually present in the form of oleates, stearates, laurate and palmitate called Polysorbate (for example, Tween®).

In addition, as non-ionic surfactants used Alkylglucoside.

In this case, PR is doctitle quantity of the component (b) is in the range from 0.1 to 20% by weight, or from 0.2 to 15% by weight, preferably from 0.3 to 10% by weight, in particular from 0.4 to 8% by weight, such as from 0.5 to 5% by weight, for example from 0.7 to 2% by weight, for example, is 1.0% by mass.

c)Aromatic alcohol

Aromatic alcohols to be used according to the invention, chosen preferably from (i) aryloxyalkanoic (monoaryl ethers glycol), (ii) arylalkyl and (iii) oligoclonal arolovich ethers.

(i) Aryloxyalkanoic used according to the invention have the formula Ar-O-(CHR)n-OH, where R = independently H (n≥2) or C1-C6-alkyl, and n is an integer and preferably from 2 to 10, more preferably from 2 to 6, in particular 2 or 3. Although the group Ar may be a substituted cycle or unsubstituted aryl group, preferred is an unsubstituted aryl, for example phenyl or naphthyl. Illustrative aryloxyalkanoic used according to the invention are Phenoxyethanol and phenoxypropanol. Preferred phenoxypropanol represent 1-phenoxypropan-2-ol, 2-phenoxypropan-1-ol, or mixtures thereof, and 3-phenoxypropan-1-ol.

(ii) Arylalkyl used according to the invention have the formula Ar-(CHR)n-OH, where R = independently H or C1-C6-alkyl, and n is an integer and preferably from 1 to 10, more preferably from 1 to 6, and often the spine, 1, 2, 3 or 4. Although the group Ar may be a substituted cycle or unsubstituted aryl group, preferred is an unsubstituted aryl, for example phenyl or naphthyl. Illustrative arylalkyl represent 3-phenylpropane-1-ol, phenethyl alcohol, fertility alcohol (3,4-dimethoxyphenylethylamine alcohol, benzyl alcohol and 2-methyl-1-phenyl-2-propanol. (iii) Oligoaniline akrilovye ethers include, for example, Phenoxyethanol-triethanol and-oligoether, and phenoxybiphenyl, -tryptophanol and-oligoprobes.

Most preferably, component c) is Phenoxyethanol.

The preferred amount of component c) are in the range from 0.2 to 15% by weight, preferably from 0.3 to 10% by weight, more preferably from 0.4 to 8% by weight, in particular from 0.5 to 7% by weight, such as from 0.7 to 3% by weight, for example approximately 2.0% of the weight.

d)Polyol

Preferred polyols are selected from 1,2-propylene glycol, 1,3-propylene glycol, butane-1,4-diol, sorbitol (hexa-1,2,3,4,5,6-hexol) and glycerol, and glycerol is particularly preferred. The preferred amount of component (d) ranges from 0.05 to 5% by weight, preferably from 0.1 to 3% by weight, more preferably from 0.2 to 2% by weight, in particular from 0.25 to 1% by weight, such as from 0.3 to 0.7% by weight, for example amount is about 0.4% by weight.

e) Fruit acid and/or its salt

Compositions of the invention may further include (e) from 0.05 to 10% by weight of at least one fruit acid and/or its salts. Suitable fruit acids selected from citric acid, lactic acid, malic acid, tartaric acid, gluconic acid, fumaric acid and succinic acid, and sodium gluconate is particularly preferred. Preferred ranges of amounts of the component (e) represent from 0.1 to 5% by weight, preferably from 0.2 to 3% by weight, more preferably from 0.25 to 2% by weight, in particular from 0 to 1% by weight, such as from 0.3 to 0.7% by weight, for example, the preferred amounts are about 0.4% by weight.

f) Flavoring and/or sweetener

Compositions of the invention may further include (f) from 0.025 to 10% by weight of the flavoring and/or sweetener. Suitable sweeteners selected from alitame, aspartame, dulcina, neohesperidine DC, reveal, Sucralose, Susana and thaumatin. Neohesperidin DC (neohesperidin dihydrochalcone; 1-(4-((2-O-[6-deoxy-α-L-mannopyranosyl]-β-D-glyukopiranozil)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone) is a compound having the following formula:

Neohesperidin D

Particular preference is as podslastitel is given to aspartame and/or neohesperidine DC.

Preferred flavors are such that well conceal or disguise the bitter taste piperidinyloxy and well tolerated by the user.

g)Acid, base and/or buffer

Compositions of the invention can further include an acid, a base and/or buffer to establish the pH. In this case, it is preferable that the component (g) is present in an amount which sets the pH from 2 to 8, preferably from 2.5 to 7, more preferably from 3 to 6, in such a range as from 3.5 to 5, for example a pH of approximately 4.

The preferred mass ratios are:

component a):the flavor is from 1:100 to 50:1, preferably from 1:10 to 2:1;

component a):sweetener is from 1:200 to 5000:1, preferably from 1:10 to 10:1;

flavor:sweetener is from 1:20 to 1000:1, preferably from 1:10 to 100:1.

Because of the composition of the invention exist in the form of aqueous solutions, preferably having a high water content equal to at least 50% by weight, more preferably at least 60% by weight, in particular at least 70% by weight, such as at least 80% by weight, for example at least 90% by weight, for example at least 95% by weight of water, they are typically single-phase and transparent.

According to the invention it was found that the presence of the various components is tov is not necessary or even adversely. In preferred embodiments of the invention these components, therefore, are not present in the compositions.

Preferably, according to the invention, the compositions do not contain Quaternary ammonium compounds, which necessarily required according to US 2005/0169852 A1. Unlike piperidinemethanol, according to the present invention, the standard Quaternary ammonium compounds such as, for example, cetylpyridinium chloride and benzalkonium chloride, lead to a strong foaming at the mouth rinse.

Preferred compositions according to the invention do not contain hydrogen peroxide or peroxide releasing compounds, which must be prescribed according to EP 0252278 A2. Disadvantages peroxides are their poor compatibility with mucous and limited stability in the composition.

The composition according to the invention also preferably do not contain betaine and/or amine oxide, the active compounds of two classes which are offered according to US 4420484 A1. Standard commercial betaines, such as cocamidopropylbetaine lead to undesirable strong foaming water compositions. In addition, it is believed that the presence of oxides of amines combined with the presence of nitrosamines, which are known to be carcinogenic and therefore cause fear.

To the position according to the invention, in addition, preferably not contain aldehydes, which must be prescribed according to DE 4201391. Aldehydes of concern from the point of view of toxicology.

Preferred compositions according to the invention, moreover, does not contain silicone oils. Silicone oils typically have low solubility in water, and their presence is thus difficult to obtain a single-phase composition.

Preferred compositions of the invention contain fatty alcohol at less than 10% by weight, in such quantity as less than 5% by weight, in particular less than 3% by weight, for example less than 1% by weight. In a particularly preferred embodiment, the fatty alcohol is missing.

The invention also relates to the use of possessing antimicrobial activity of the composition as a solution for mouthwash or oral antiseptic. The most important indications are:

antimicrobial mouth rinse before dental procedures and jaw surgical intervention;

prophylaxis and therapy-induced chemo - or radiation mucositis;

improving oral hygiene in patients with a weakened immune system;

antimicrobial mouth rinse after accidental exposure to infectious materials in the oral cavity;

application to and possibly posioperating interventions;

antimicrobial care for the oral cavity in the case of fractures of the jaw with premaxillary immobilization;

antiseptic treatment of root canals;

treatment of dental caries and periodontal disease;

implantology;

additional rinsing of the mouth to the daily routine of oral hygiene in special patient groups (e.g., immunosuppression);

reducing the formation of plaque and preventing gingivitis in patients whose teeth cannot be cleaned manually;

the use of before and after dental treatment to reduce the number of microbes in aerosols;

prevention or reduction of bacteremia in patients with increased risk (e.g., prevention of endocarditis);

preventing infections in patients undergoing intensive therapy;

preventing infections in patients with artificial ventilation of the lungs;

application before intraoral injections and

treatment of carriers of resistant microorganisms in the oral cavity (e.g., MRSA).

In particular, the invention also relates to the application of the above-mentioned components a)to d) and, if necessary e), (f) and/or g) to obtain a solution for rinsing the mouth, in particular for the control of MRSA and/or E. faecalis.

When all the evidence you can use the solution to rinse the mouth and/or oral antiseptic that contains actinidin. The fields is their given treatment in case of infection with MDR pathogens such as MRSA (methicillin-resistant S. aureus), and treatment of periodontal disease and root canal. Benchmarking effect on the organism E. faecalis, which plays an important role in infections of the root canal, show that the preferred composition according to the invention is much better than Chlorhexamed forte®.

Advantages of the invention follow, in particular from the examples below.

Examples

Composition

1234
Octenidine the dihydrochloride0,100,100,100,10
Cremophor RH 401,001,001,001,00
Phenoxyethanol2,002,002,002,00
Glycerin0,4250,4250,4250,425
Gluconate sodium 0,400,400,400,40
Flavor-0,250,250,25
Neohesperidin DC-0,020,02-
Apartmeny powder--0,200,20
Citric acidto pH 4to pH 4to pH 4to pH 4
Purified waterto 100.00to 100.00to 100.00to 100.00
5678
Octenidine the dihydrochloride0,050,100,200,20
Cremophor RH 40 1,001,001,001,00
Phenoxyethanol---0,90
Glycerin0,4250,4250,4250,425
Gluconate sodium0,400,400,400,40
Flavor0,250,250,250,25
Apartmeny powder0,200,200,200,20
Citric acidto pH 4to pH 4to pH 4to pH 4
Purified waterto 100.00to 100.00to 100.00to 100.00
9
Octenidine the dihydrochloride0,10
Eumulgin HRE 40PH1,00
Phenoxyethanol2,00
Glycerin0,425
Gluconate sodium0,40
Flavor0,25
Apartmeny powder0,20
Purified waterto 100.00

Example 1

Quantitative suspension experiment using E. faecalis (ATCC 19433)

Used test method: Extract from standard methods DGHM (German society for hygiene and Microbiology) for test methods, chemical disinfection, September 1, 2001.

9. Determination of the bactericidal or fungicidal activity in a quantitative suspension experiment

9.1 Quantitative suspension experiment using bacteria (except mycobacteria) and fungi

9.1.3 Methods

9.1.3.1 Principle

In the sample of the test product contribute to bacterial or fungal suspension and this mixture was kept at the test temperature. Upon expiration of the selected and specified time steps an aliquot of the mixture immediately neutralized using validated methods for examining existing bactericidal or fungicidal properties. In each sample, determine the number of cells and then calculate the reduction ratio. The method of choice is the method the solvent neutralization. Only if suitable neutralizing agent is not found, the method can be used membrane filtration. Tests at relatively low or relatively high organic load depends on application conditions ispytyvaemoj the drug.

9.1.5 Assessment

First of all assess the nutrient medium, where the number of CFU (colony forming units) is from 15 to 300. The reduction factor (RF) is calculated by the following formula:

Log10RF = log10(CFU col) - log10(CFU D)

CFU col: the number of CFU per ml in the absence of action of the product

CFU D: the number of CFU per ml after the action of the product.

In the test report values CFU should be brought to the stage of dilution, log10(CFU D), and the value of RF must be tabulated.

Comparison of composition 9 with a commercial product. Given the coefficients decrease.

Conc. (1)10 sec15 sec20 sec30 sec
Composition 980%6,396,386.42 per6,39
50%6,396,386.42 per6,39
Chlorhexamed forte®80%01,91 2,223,98
50%0000
(1) Conc. = Concentration

Result:

Composition 9, containing only 0.1% of octenidine, works much better against the organism Enterococcus faecalis related to the treatment of root canal than a commercial product Chlorhexamed forte®, containing 0.2% chlorhexidine of digluconate.

Example 2

Quantitative suspension experiment using different MRSA-isolates in dirty conditions (composition 6)

Investigated the antimicrobial activity of the composition 6 against multidrug resistant isolates of Staphylococcus aureus. Antimicrobial activity was determined in a quantitative suspension experiment in dirty conditions," according to the Compendium of methods DGHM, 2001 (mhp Verlag, ISBN 3-88681-042-9). The selected time steps was 10, 20 and 30 seconds. Used MRSA isolates No. 740, 686 710 and were provided by the Institute of hygiene, Hamburg.

The above factors reduce:

MRSA-isolatesTime10 sec20 sec 30 sec
MRSA No. 7045,26of 5.82>6.42 per
MRSA No. 6865,33>6,47>6,47
MRSA No. 7105,125,59>6,27

Result:

Contains actinidin solution for rinsing the mouth in the tested concentration even when the exposure time to 10 seconds demonstrated sufficient activity against all MRSA-isolates.

1. Possessing antimicrobial activity of the composition is water-based, which consists of:
a) from 0.001 to 10% by weight of octenidine dihydrochloride,
b) from 0.05 to 30% by weight of nonionic surfactant - derived fatty acids
d) from 0.01 to 10% by weight of a polyol selected from 1,2-propylene glycol, 1,3-propylene glycol, butane-1,4-diol, sorbitol (hexa-1,2,3,4,5,6-hexol) and glycerol or mixtures thereof;
e) from 0.05 to 10% by weight of fruit acid and/or a salt thereof, selected from citric acid, lactic acid, malic acid, tartaric acid, gluconic acid, fumaric acid and succinic acid, or mixtures thereof; f) from 0.025 to 10% by weight of the flavoring and/or podslastiteli selected from alitame, aspartame, dulcina, neohesperidine DC, reveal, Sucralose, Susana and thaumatin or mixtures thereof; and water to 100%.

2. The composition according to claim 1, characterized in that it comprises from 0.01 to 1% by weight, preferably from 0.03 to 0.5% by weight, more preferably from 0.05 to 0.2% by weight, in particular from 0.08 to 0.12% by weight, such as 0.1% by weight of the component (a).

3. The composition according to claim 1, characterized in that the nonionic surfactant is selected from monoglycerides alkoxysilane fatty acids and mixtures thereof and a monoglyceride of a fatty acid, a substituted 5-100-ethoxypropane is preferred, in particular the monoglyceride of a fatty acid, a substituted 20-70 ethoxypropane, for example 40 ethoxypropane.

4. The composition according to claim 1 or 3, characterized in that it comprises from 0.2 to 15% by weight, preferably from 0.3 to 10% by weight, in particular from 0.4 to 8% by weight, in such a range as from 0.5 to 5% by weight, for example from 0.7 to 2% by weight, for example about 1.0% by weight of component b).

5. The composition according to claim 1, characterized in that the polyol is particularly preferred as component d) glycerin.

6. Composition according to claims 1 and 5, characterized in that it contains from 0.05 to 5% by weight, preferably from 0.1 to 3% by weight, more preferably from 0.2 up to 2% by weight, in particular from 0.25 to 1% by weight, in such a range as from 0.3 to 0.7% by weight, for example about 0.4% by weight of the component (d).

7. The composition according to claim 1, characterized in that the salt fruit acid is particularly preferred as component (e)sodium gluconate.

8. The composition according to claim 1 or 7, characterized in that it contains from 0.05 to 5% by weight, preferably from 0.1 to 3% by weight, more preferably from 0.2 to 2% by weight, in particular from 0.25 to 1% by weight, in such a range as from 0.3 to 0.7% by weight, for example about 0.4% by weight of the component (e).

9. The composition according to claim 1, wherein the sweetener is selected from aspartame and/or neohesperidine DC that are particularly preferred.

10. Application of possessing antimicrobial activity of the composition according to any one of claims 1 to 9 as a solution for rinsing the mouth.

11. The use of claim 10 for controlling methicillin-resistant S.aureus and/or .faecalis.



 

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17 cl, 3 tbl

FIELD: medicine.

SUBSTANCE: invention is referred to the method of electrochemical teeth whitening which consists of putting on the teeth first the solution of salt of transition metal and then oxidizing agent while limiting the effect of metal salts and oxidizing agent on non-dental oral tissues. After that positive and negative electrodes are configured in oral cavity in such a way that negatively charged electrodes contact with teeth and electric current is sent only in oral cavity to said oxidizing agent for its activation and reduction. Oxidizing agent contains hydrogen peroxide, solution or gel of carbamide peroxide or sodium perborate. The invention is also referred to teeth whitening device that contains applicator suitable for putting salt of transition metal and oxidizing agent on teeth. Applicator is made in shape of dental tray and has first and second ends to which the electrodes are connected with the possibility of sending electric current through the applicator as well as sealing bulge for limiting the oxidizing agent effect on non-dental oral tissue. The group of inventions provides for regulation of safe application, supply and distribution on teeth of oxidizing agent.

EFFECT: simple and safe method of teeth whitening; minimal effect of oxidizing agent on non-dental oral tissue.

31 cl, 7 dwg, 1 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: invention is referred to the field of medicine and pharmacy, namely to the dentistry products and is related to effervescent soluble solid composition for cleaning of dentist tools. The composition contains the source of acid and main amino acid in form of soluble carbonate salt where the main amino acid is arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutane acid, diaminopropionic acid, its salts and/or its combinations. The invention is also related to the method of cleaning of dentist tools involving the addition of said composition to water solvent and immersion of a dentist tool in ready solvent for the period of time needed for effective cleaning of dentist tools.

EFFECT: effective cleaning of dentist tools.

20 cl

FIELD: medicine.

SUBSTANCE: group of inventions relates to compositions for oral cavity care, containing mucoadhesive polymers, and to their application for reducing symptoms associated with xerotomia. Claimed compositions contain cation-sensitive mucoadhesive polymer; and cation-releasing compound; where cation-releasing compound is incapsulated into degradable capsule. Examples of mucoadhesive cation-sensitive polymer materials include gellan gum and carageenan. Cation-releasing compounds include salts, such as calcium salts, sodium salts, salts of metals, preferably calcium chloride. Materials, applied for incapsulation of cation-releasing compounds include silicon, copolymer of lactic and glycolic acids (PLGA), alkylcellulose polymer. Composition for oral cavity care can be made, for instance, in form of liquid for mouthwash, spray for oral cavity care or toothpaste.

EFFECT: claimed compositions can be used for reduction and/or prevention of "dry mouth".

12 cl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceuticals and concerns a therapeutic agent for improvement of skin properties containing a compound of formula (I): as an active ingredient.

EFFECT: invention provides a medical product effective for prevented dry skin, reduced skin roughness and skin darkening associated with hyperkeratosis ensured by skin moisture preservation, and effective for impaired skin functions for the various reasons.

3 cl, 1 ex

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology and represents a method for preparing a biologically active component for making a skin care product, involving lactic culture growing on regulated nutrient mediums, stabiliser addition to the prepared suspension and packing, and differing by the fact that there is used a lactic culture containing lactic organisms of different taxonomic groups, containing 2-50% of bacteria and 98-50% of yeast (in amount of living cells); as stabilisers, the suspension is added with substances specified in: orcin, hexylresorcin, starch, gelatin; it is followed by oxygen-free vacuum packing.

EFFECT: invention provides higher range of probiotic active agents found in the skin care products with improved shelf-life and prolonged action.

8 cl, 3 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to creation of composition for oral cavity care, which have, at least, two vegetable active ingredients, obtained from plants. Composition for oral cavity care also includes per oral acceptable carrier for introduction of sufficient amount of, at least, two active ingredients in vivo.

EFFECT: vegetable active ingredients ensure to compositions for oral cavity especially efficient antimicrobial (antibacterial, antiviral and/or antifungal antioxidant anti-inflammatory ageing slowing down and/or healing properties.

5 cl

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely, to proctology, and is intended for low-invasive treatment of complete complex pararectal fistulas. Sinus tract is examined, its direction and presence of external and internal holes are determined. Successively, each sinus tract is treated through external hole, with obturation of external hole of untreated sinus tract, as minimum two times, with two-day interval. Treatment is carried out during 40-80 seconds by ultrasonic fluctuations with frequency 20-60 kHz with simultaneous supply of liquid phase. As liquid phase, used is alcohol solution in amount 10-20 ml, depending on sinus tract dimensions, which is supplied at rate 0.25 ml per second. As alcohol solution used is three percent alcohol iodine solution or seventy percent ethyl alcohol.

EFFECT: method is low-invasive, makes it possible to eliminate injury of anatomical structures of anal canal, reduce treatment cost, can be carried out on outpatient basis.

2 ex, 2 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to - physiotherapy. A method involves simultaneous processing of an area containing microorganisms by a photosensitiser and photocatalyst composition. Thereafter they are kept for a period of time required for effective binding of the composition and microorganism cells. Then this area is exposed to optical radiation at wave length related to a maximal photosensitiser and photocatalyst absorption and power density required for composition activation. The photosensitiser is indocyanine green. The photocatalyst is titanium dioxide nanoparticles.

EFFECT: method provides more effective inactivation of pathogenic and opportunistic microorganisms ensured by higher microorganism radiosensitivity.

8 cl, 5 dwg

FIELD: medicine.

SUBSTANCE: invention is referred to medicine, physiotherapy. A method involves simultaneous processing of an area containing microorganisms by a photosensitiser and photocatalyst composition. They are kept for a period of time required for binding of the composition and microorganism cells. Then this area is exposed to optical radiation. An emission wavelength relates to a maximal photosensitiser and photocatalyst absorption and power density required for composition activation. The photosensitiser is methylene blue or/and brilliant green, and the photocatalyst is titanium dioxide nanoparticles.

EFFECT: method provides an effective microorganism inactivation with using the lower concentration of the photosensitiser ensured by simultaneous use of the photocatalyst and the photosensitiser.

9 cl, 3 tbl, 3 dwg

FIELD: medicine.

SUBSTANCE: method for producing biocide consists in Na-form bentonite activation by sodium ions by means of processing with an aqueous solution of sodium chloride followed by chlorine anion removal with washing and filtration of the prepared raw material. Thereafter, the prepared raw material is intercalated by bactericidal metal ions by processing of inorganic salts in aqueous solutions: silver nitrate, copper sulphate, zinc sulphate or nitrate; sodium salts are removed by washing of the biocide product with deionised water; then the product is filtered, dried and grinded to particle size 20-150 nm. The activation and intercalation processes are performed by exposure to ultrasound at frequency 20-50 kHz and intensity 10-100 Wt/cm2, and the purification process of the intercalated product from sodium salts is two-staged: at first, the product is decanted, and then washed in deionised water containing 30 "ppm" - 100 "ppm" of an alkaline metal ion complexing agent of crown-ethers of molecular weight 264 and less.

EFFECT: production of biocide exhibiting fungicidal and bactericidal efficacy and used in preparations, compounds, compositions.

6 cl, 6 ex, 1 dwg

FIELD: medicine.

SUBSTANCE: according to the first version, an antiseptic ointment contains a base and an antiseptic agent in the form of an Ag+ or/and Cu2+ intercalated disperse bentonite powder which is produced by modification of Na+ preliminary enriched bentonite by aqueous solutions of silver nitrate or copper sulphate. A base is medical Vaseline or mixed medical Vaseline and lanolin and additionally contains a vegetable essential oil. The antiseptic ointment according to the second version contains a base and an antiseptic agent in the form of Ag+ or/and Cu2+ intercalated bentonite powders and a Zn2+ intercalated bentonite powder which is produced by modification of prepared raw Na+ enriched bentonite processed by solutions of inorganic salts of zinc chloride (ZnCl2) or zinc sulphate (ZnSO4), cleared from sodium salts and dispersion. A base is medical Vaseline or mixed medical Vaseline and lanolin and additionally contains a vegetable essential oil.

EFFECT: implementation of the invention provides producing ointments for outward application of prolonged antiseptic action with low cost of the active ingredients biologically compatible with various human and animal skin integuments.

8 cl, 5 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of veterinary. Method includes application of water solution of composite antiseptic. Composite antiseptic contains 0.01% ASD fraction 2 and 0.015% of C26H47CIN2O·H2O.

EFFECT: method makes it possible to increase recovery level and reduce mastitis morbidity in milk cows.

1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical preparations, and can be used in medical and veterinary practice. An antimicrobial, antimycotic, antiviral and anti-inflammatory agent, contains the natural mineral bischofite in the form of a standardised bittern of density 1.268 g/cm with magnesium chloride content 95-96%, and iodine in the following proportions, %: natural mineral bischofite bittern 98, iodine 2.

EFFECT: higher pharmacological efficacy.

4 tbl

FIELD: medicine.

SUBSTANCE: invention relates to medicine and is intended for treatment of alveolites of upper and lower jaws. Necrotic masses are removed from socket of extracted tooth. Socket is washed with warm furacillin solution and additionally with solution of butole from a syringe. Socket is processed by ultrasound. After that, alveolus is loosely filled with turunda, soaked with butolan ointment. After stopping inflammation, lyophilised spongiosa, saturated with butol solution is introduced into dental socket by means of low-frequency ultrasound 2.5-40 kHz. From above socket is covered with tampon.

EFFECT: method makes it possible to stop inflammation, create optimal conditions for operative osteogenesis, preventing atrophy of alveolar processes of jaws.

1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of medicine, namely to chemical-pharmaceutical industry and, can be applied for treatment of local purulent diseases of soft tissues. In accordance with invention, as active substance, it contains mixture of calcium lactogluconate, calcium carbonate, sodium bicarbonate, benzocaine and saccharose with following component ratio, wt %: Calcium lactogluconate 16.0-65.0; Calcium carbonate 2.0-13.0; Sodium bicarbonate 1.0-3.0; Benzocaine 0.1-13.0; saccharose to 100.0. Method of clamed substance obtaining, consists in preliminary milling and grinding of upper said components and after that, mixing of milled components in proper upper said proportions until homogeneous powder is obtained.

EFFECT: medicine ensures high anti-microbial activity of components in wound, quick action and, as a result, 2-3 time increase of treatment efficiency in general.

2 cl, 2 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers namely to dermatology and can be used for prevention and treatment of the pustulous diseases caused by bacterial skin defeats. For this purpose the damaged skin amazed and adjoining areas are worked with the antiseptic of "Likvacid" received with the use of trinol by means of its preliminary dissolution in a dimethyl sulfoxide in the ratio 1 mas.h. to 0,9 mas.h., accordingly, at the temperature not below indoor temperature before dark blue coloring of a mix occurs, and mixture then with a filler based on alcohol with addition of glycerin and further filtration of the received mix, herewith using as a filler of a solution of acid in ethyl spirit with its initial concentration accepted that the end-product has not less than 70 %, and with a choice of all components in the following ratio, mas.: trinitrotoluene- 0,25-1,5, a dimethyl sulfoxide - 1,0-10,0, acid - 0,5-1,0, glycerin - 17,5-23,0, ethyl spirit - the rest. The skin is greased with a wadded tampon with frequency of 2-3 times a day. Thus duration of therapy is not less than 17 days and to epulosisof the damaged surface. Or in case of the second invention grease the damaged skin and adjoining areas are greased with a wadded tampon with frequency of 2-3 times a day. The therapy course is not less and in addition is accepted than 10 days by taking "Likvacid" per oral 2-3 times a day within no more than 10 days. Herewith adults people take 11-16 ml, young men to 18-year-old age - 5-10 ml.

EFFECT: the use of the given inventions allows carrying out effective preventive maintenance and treatment in case of optimum terms of therapy.

2 tbl, 1 dwg

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