Remedy for treatment of kidney stone disease and urogenital system cysts
SUBSTANCE: invention is referred to the area of medicine. The remedy for treatment of kidney stone disease of urogenital system is the bile of poultry and game. The bile of healthy poultry or game can be using for treatment in any form, including raw fresh bile, solution containing certain dose of the bile, as a composition, containing food product, for example, honey, and raw fresh bile as a powder dissolved in the water, as tablets or capsules.
EFFECT: The invention will allow to increased number of products of non-chemical natural origin having increasing effectiveness for the treatment of kidney stone disease.
The invention relates to medicine, in particular to the treatment for diseases of the genitourinary system.
Known for the treatment of pyelonephritis - triethanolamine salt of fumaric acid (see Russian Federation patent No. 2194500). Three-2-acetylamino fumarate, triethanolamine salt is derived from fumaric acid, it is produced by the interaction of fumaric acid with triethanolamine. General formula C10H18O7N.
However, when treating patients with this drug does not always achieve the desired clinical effect, as some patients are allergic skin rash, dyspepsia and nausea.
It is also known agent for the prevention and treatment of urolithiasis, described in the patent of the Russian Federation No. 2205655. This tool contains the following components, wt.%:
|rhizome upright cinquefoil||13-16|
|the leaves of lovage dosage||5-10|
|the leaves of rosemary||3-6|
|the herb horsetail||3-6|
|the leaves of the bearberry||3-6|
|the root of the madder||5-10|
|beta carotene||0.5 to 1.5|
|pyridoxin||0.5 to 1.5.|
Mentioned means, essentially, is a biologically active additives (BAA), which consists of natural herbal ingredients and chemical compounds.
However, as indicated in the description of the patent, and we know from the medical literature, the Supplements are not sufficiently effective in the treatment of acute inflammatory processes. In General, Supplements are used to prevent diseases. They relate to food, the special significance is to be placed.
In addition, the described tool includes a large number of components, it is difficult to prepare.
The basis of the invention is the task of expanding the range of non-chemical means of natural origin, with high efficiency, for the treatment of urolithiasis patients with cysts in the prostate gland or kidneys.
The problem is solved by the use of bile in poultry and wild birds as drugs to treat diseases of the genitourinary system.
It is known the use of bear bile in the composition of ointments, which has anti-inflammatory and wound healing effect (see Russian Federation patent No. 2246959).
Known ointment, which includes honey, mummy, bear bile, lanolin oil, aloe Vera, oil, plantain, oil sazegara intoxicating (see the patent of the Russian Federation No. 2002108231).
This ointment also has anti-inflammatory and wound healing effect.
Known antitumor agent containing ampicillin sodium salt, an alcohol solution of iodine, sugar, water and medical bile (see Russian Federation patent No. 2145854).
It is known for the treatment of HIV-infected patients containing solutions or powders herbs oldenlandia, rhizomes of Polygonum snake, mountaineer comb, the fruits of schisandra chinensis root of slimnic the Baikal, cow's bile and set other medicinal roots (see the patent of the Russian Federation No. 2003110940).
Known gastrointestinal preparation containing encapsulated powders of the mucous membrane and the surface epithelium of the muscular stomach of birds and dry shredded chicken bile (see Russian Federation patent No. 2189810). This drug has proteolytic, hepatoprotective and holelitoliticescoe action.
From the medical and patent literature is unknown, the use of bile in poultry and wild birds, both individually and in the composition of ointments or other pharmacological drugs as a means to treat diseases of the genitourinary system entities that have a cyst in the prostate gland or kidneys.
Bile poultry and wild birds is a juice that is secreted into the cavity of the duodenum. It is produced by the liver. Both bile and excreta - it eliminated from the body the breakdown products of hemoglobin. In the composition of bile consists of bile salts, cholesterol and bile pigments, biliverdin and bilirubin.
The proposed medicinal product is of natural origin. Bile can be obtained in large quantities on farms or by extraction of the gallbladder to the slaughter of domestic or wild birds, purchased at market.
Bile healthy domestic or wild is the tics can be applied in any form, in particular:
a) raw fresh, swallowing a bag of bile;
b) raw fresh without the bag;
C) in the form of a solution containing a specific dose dissolved bile;
g) in the form of a composition containing a food product, such as honey, and raw fresh bile;
d) in the form of a powder, pre-dissolved in water;
(e) in powder form;
g) in the form of tablets;
C) in encapsulated form, etc.
Bile domestic or wild birds can be pre-frozen, and then apply in any form, above.
In addition, you can apply bile two birds, such as chicken and duck, duck and goose, etc.
Examples, confirming the effectiveness of the inventive method.
Patient S., aged 40. Weight 70 kg
Diagnosis: kidney stones, cystic pyelonephritis, a cyst of the left kidney, pyelonephritis bilateral keen.
Complaints of pain in the lumbar region. Pains are intermittent in nature. Increased pain is associated with changes in body position. Considers himself ill for more than three years. Care was addressed repeatedly. A state of moderate severity. The skin is clean. The temperature is raised.
Blood pressure 140/90.
Reaction is neutral, beats. 1024.
Urinalysis L 60×80 in sight.
Erythrocytes 10-12 in the field of view.
The epithelium is continuous in view.
Salt in large numbers.
The blood test is normal.
Ultrasound of the kidneys: balii (sack) right kidney calculus has a 0.5×1 cm In balii (pelvis) of the left kidney with calculus of 1.5×2 cm
In the structure of the brain layer both kidneys are determined by small cysts size of 0.3×0.3 to see
The ECHO structure of both kidneys compacted, fine-grained.
Review Rn-gram in baleh (pelvis) of both kidneys shadows that give reason to suspect the stones.
The patient took the raw natural chicken bile (vegetarianas reproductive birds) 1 times a day after eating, swallowing one gall bag for 21 days. Objective indicators normalized.
Urinalysis: protein - traces, L 8-10 in the field of view.
Erythrocytes - no, the epithelium 10-15 in the field of view.
When repeated ultrasound of the presence of stones in both kidneys is not defined.
The presence of cysts in both kidneys is determined, but their sizes decreased significantly.
There is a decrease in density of the ECHO patterns of the renal parenchyma.
On the control Rn-gram (review) shadows concretions were found.
After a month the patient had repeated the course of taking chicken bile, which took a day to half a bile bag.
Urine analysis was normal.
Ultrasound kidney shadows suspicious cystic lesions in kidneys, not in the manifest.
Patient Century, 50 years. Weight 85 kg
Complaints of pain in the perineum, the weakening of erection.
Urine analysis: straw-yellow color.
Protein and sugar is not found.
The reaction is alkaline.
Rn-gram. In the study of prostate gland tight, swollen, Magdolna furrow smooth. In the parenchyma palpable seal, as in the right and left lobes.
Ultrasound of the prostate gland. Iron is increased in the transverse dimension. In the parenchyma of the right lobe is defined cystic formation with a size of 0.3×0.5 cm with a clear path. In the left lobe two cystic masses of 0.3×0.4 cm with a clear path. In the right and left lobes are small concretions.
Diagnosis - calculate cystic prostatitis.
Appointment of bile domestic duck 1 time per day after eating one gall bag within 21 days.
After the first course of treatment in both lobes of the prostate the size of the cysts was significantly reduced, concrements are not detected.
Patient assigned to two treatment natural raw bile domestic ducks under 31 days each, with an interval of one month between the second and third courses. In this second course of treatment the patient received 50% of the content of the bag, and in the third, and 25% of the content of the bag.
After three courses of treatment shade cysts are not defined, shadows, podozritelen the e in the concretions, not marked. Urine analysis was normal.
If using chicken or duck bile confirmed that bile is an effective tool for the treatment of urolithiasis and calculate cystic prostatitis.
For the treatment of urolithiasis urinary system, characterized in that it is the gall of domestic and wild birds.
SUBSTANCE: invention relates to compounds of formula (I) given below or pharmaceutically acceptable salts thereof:
[where: each of X, Y, Z and W independently denotes a methane group which optionally contains substitutes selected from a group of substitutes α, or a nitrogen atom (except when all elements X, Y, Z and W denote a methane group which optionally contain substitutes selected from the group of substitutes α); A denotes -(C(R3)(R4))m1-; B denotes -O-; D denotes -C(O)-; m1 equals 0; Q denotes a methane group or a nitrogen atom; R denotes a group of formula (II)
, where R6 denotes a lower alkyl group; R7 and R8, together with the nitrogen atom with which they are bonded, form a 5-6-member nitrogen-containing aliphatic heterocyclic group; and where the group of substitutes α includes the following substitutes. Group of substitutes α: halogen atom, hydroxyl group, lower alkyl group, alkoxyl group (said group can be substituted with a cycloalkyl group), amino group, mono- or disubstituted lower alkylamino group, aryl group (said group can be substituted with a halogen atom, a -SO2CH3 group), aryloxy group (said group can be substituted with a halogen atom), heteroaryl group, where 'heteroaryl group' denotes a 5- or 6-member monocyclic saturated or unsaturated group containing 1-2 heteroatoms selected from an oxygen atom or a nitrogen atom (said group can be substituted with an alkoxyl group, alkyl group). The invention also relates to a histamine 3 receptor antagonist, histamine 3 receptor inverse agonist, a prophylactic or medicinal agent, as well as a pharmaceutical composition.
EFFECT: obtaining novel biologically active compounds having histamine H3 receptor antagonist or inverse agonist action.
15 cl, 57 ex, 1 tbl
SUBSTANCE: invention refers to medicine, namely to oncology, and can be used in partial or complete urinary tract obstruction associating renal malfunction in the patients suffering malignant growths. That is ensured by a double biological Perftoran test on the first day after prolonged postrenal obstruction released in the patients suffering developed ischemic-reperfusion renal damage and showing a creatinine level 0.4 mmol/l and more. If observing no anaphylactoid reactions, Perftoran is introduced in dose 2-4 mg/kg of body weight at average speed 40-60 drops a minute. On the third day, the preparation is introduced again in the same dosage if having preserved the creatinine value 0.4 mmol/l and more.
EFFECT: method allows higher clinical effectiveness in renal insufficiency in urinary tract drainage in the oncological patients due to the introduction of the gas-transport preparation in a certain regimen.
SUBSTANCE: invention refers to medicine, namely to children's urology, and can be used for prevention of postoperative complications in children with obstructive uropathies. That is ensured by administration of Kipferon® per rectum 1 candle 3 times a day 7 days prior to the operation.
EFFECT: method allows higher nonspecific pre-operative resistance of a child's body and provided more smooth early postoperative course with reduced time of staying in hospital ensured by evident antiviral, antiparasitic and antiproliferative activity.
4 tbl, 3 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed group of inventions relates to medicine, namely to therapy and deals with application of organic compound -rennin inhibitor aliskiren for treatment and prevention of type 2 diabetes and kidney disease. For this purpose aliskiren is introduced in efficient amount as monotherapy.
EFFECT: invention ensures efficient treatment and prevention of said diseases due to aliskiren ability to increase sensitivity of tissues to insulin and reduce proteinuria.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of medicine, namely to cardiology, and can be used for correction of kidney dysfunction in patients with stable stenocardia in combination with hypertension. For this purpose at the background of standard therapy, which includes inhibitor of angiotensin-converting enzyme, beta-adrenoblocker, aspirin and statin, Medicaqtion ivabradin is administered in day dose 5-15 mg in 2 intakes, daily, during 6 months.
EFFECT: method makes it possible to increase efficiency of kidney malfunction correction due to positive dynamics of GFR, level of C-terminal telopeptide type I collagen and TIMP-1.
1 tbl, 2 ex
SUBSTANCE: invention relates to compounds of formula
, where the dotted line in the 6-member nitrogen-containing ring Z of formula (I) (said ring Z consists of ring atoms numbered 1 to 6) indicates that a double bond is either present in the 3,4-position of the ring Z of formula (I), or a double bond is absent in ring Z of formula (I); and where the double bond may be present in the 3,4-position of the ring Z of formula (I); or: the double may be absent in ring Z of formula (I) if: i) X denotes N or N+-O-, or ii) V denotes -O-CH2-Q-, or iii) W denotes para-substituted phenyl or para-substituted pyridinyl, and V denotes pyrrolidinyl of formula:
X denotes CH, N, or N+-O-; W denotes para-substituted phenyl or para-substituted pyridinyl; V denotes -O-CH2-Q-, where Q is bonded with a group U of formula (I), or V denotes pyrrolidinyl of formula:
U denotes mono-, di-, tri- or tetra-substituted aryl, where the substitutes are independently selected from C1-7-alkyl and halogen; Q denotes a five-member heteroaryl with two or three heteroatoms independently selected from O and N; R1 denotes C1-7-alkyl or cycloalky; R2 denotes halogen or C1-7-alkyl; R3 denotes halogen or hydrogen; R4 denotes C1-7-alkyl-O-(CH2)0-4-CH2-; R'R"N-(CH2)0-4-CH2-, where R' and R" are independently selected from a group consisting of hydrogen, C1-7-alkyl (optionally substituted with one-three fluorine atoms), cyclopropyl (optionally substituted with one-three fluorine atoms), cyclopropyl- C1-7-alkyl (optionally substituted with one-three fluorine atoms) and -C(=O)-R"', where R'" denotes C1-4-alkyl, C1-4-alkoxy, -CH2-CF3, or cyclopropyl; or R12NH-C(=O)·(O)0-1-(CH2)0-4-, where R12 denotes C1-4-alkyl or cyclopropyl; and n equals 0; and salts thereof. The invention also relates to a pharmaceutical composition.
EFFECT: obtaining novel biologically active compounds having inhibiting effect on renin.
21 cl, 112 ex
SUBSTANCE: invention relates to novel compounds - arylamidrazone derivatives of formula ,
where R1 is a C2-C8 alkyl group or a C2-C8 alkoxy group, which can be substituted with a halogen or a C1-C8 alkoxy group; a 5-7-member aromatic heterocycle containing 1 or 2 oxygen, nitrogen or sulphur atoms, or phenyl, which can be substituted with a halogen, a C1-C8 alkyl group, a haloC1-C8alkyl group or a C1-C8alkoxy group; or NR4R5; R2 and R3 are identical or different, and each is a hydrogen atom, a halogen atom, a halogenC1-C8alkyl group, a C1-C8alkyl group, a C2-C6alkynyl group, a C1-C8alkoxy group, a cyano group, a C2-C6alkanoyl group or a C1-C8alkylsulphonyl group; A is a benzene, pyridine, quinoline or isoquinoline ring; D is a single bond or methylene; m assumes values from 1 to 3 and n assumes values from 1 to 5, having antagonistic effect on S1P3 receptors, as well as to medicinal agents and pharmaceutical compositions containing such compounds as an active ingredient.
EFFECT: improved properties.
13 cl, 161 ex, 19 tbl
SUBSTANCE: invention refers to medicine, namely to therapy and parasitology, and can be used for treating patients with chronic glomerulonephritis (CGN) combined with chronic opisthorchiasis (CO). That is ensured by introducing a cytoprotector and an antiaggregant, namely Chopytol 0.4 g 4 times a day 30 minutes before meals combined with ticlopidine 0.25 g 2 times a day for 3 weeks. If observing the improvement of the haemostatic system and urine analysis values, the therapy is prolonged for 4 weeks in the previous regimen; while the improvement of the haemostatic system and urine analysis values requires prescribing Chopytol 0.4 g 3 times a day for 3 weeks with underlying administration of ticlopidine 0.25 g 2 times a day. If necessary, the therapeutic course is repeated 6 months after.
EFFECT: method allows enabling more evident and permanent therapeutic effect ensured by the correction of endothelial, hemostatic and hepatobiliary dysfunctions in the patients suffering CGN combined with CO with reduced adverse reactions.
2 ex, 2 tbl
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to composition with fixed dose of phytate and zinc in form of Zn2+ cation for production of medication for treatment of calcification, formed as a result of hydroxyapatite crystallisation, in particularly for prophylaxis and/or prevention of hydroxyapatite crystallisation in people. Synergism of action of composition components is shown, as a result of zinc adsorption on formed hydroxyapatite crystallisation core, which increases affinity of phytate to growing crystal, enhancing its inhibitory action on crystallisation.
EFFECT: composition increases affinity of phytate to growing crystal, enhancing its inhibitory action on crystallisation.
11 cl, 3 dwg, 2 tbl, 5 ex
SUBSTANCE: invention relates to medicine, namely to experimental nephrology and can be used for prevention of systemic amyloidosis and its nephropathic form in experimental animals during its modelling. For this purpose native egg albumen is introduced to old rats subcutaneously in dose 0.025 ml/g of body weight. Simultaneously with native egg albumen as amyloidoprotective medication used is medium-mineralised sulphide mineral water. Mineral water is introduced to rats daily via probe into stomach in dose 10 ml/kg during for 60 days.
EFFECT: extension of possibilities of preventing systemic amyloidosis and its nephropathic form.
1 ex, 2 tbl, 4 dwg
SUBSTANCE: invention refers to medicine, particularly to urology, and can be used for treating chronic prostatitis and prostate adenoma. For this purpose, for three days in the morning 30-40 minutes before meals and in the evening after meals in 30-40 minutes, one teaspoon of celandine juice dissolved in 150-200 ml of water is taken. From the fourth day, for seven days in the morning and in the evening under the same scheme, one table spoon of celandine juice dissolved in 100 ml of water is taken, and additionally, a prepared mixture of sage and camomile tea in the ratio 1:1 and celandine juice in the ratio: a mixture in the form of three table spoons of sage and chamomile tea taken in the ratio 1:1, and one table spoon of celandine juice are introduced through rectum.
EFFECT: method allows relieving prostate inflammation effectively and preventing adenoma malignification with ensured prolonged and reliable remission due to normalisation of metabolic processes in a body.
SUBSTANCE: invention relates to medicine, in particular to urology, and deals with treatment of chronic prostatitis. For this purpose introduced is afala in dose 1 tablet 4 times per day sublingually during two months. Additionally combined physiotherapy is carried out, which alternates procedures of transrectal laser therapy with wavelength 0.82 nm and power 10 mW every second day with procedures of transrectal electric stimulation. Duration of each procedure constitutes 10 minutes, course includes 7-8 procedures of each type of impact.
EFFECT: method makes it possible in fast and stable way to stop inflammation and pain, improve microcirculation of blood and lymph in prostate gland tissue, recover functional activity of prostate.
1 ex, 1 tbl
SUBSTANCE: invention relates to medicine, namely to urology and can be used for treating chronic abacterial prostatitis. For this purpose, Himalayan May apples are resorbed before dinner in a single dose 80-100 g daily for 30 days.
EFFECT: method allows reducing considerably pain intensity with rate fall, and also normalising an ammonium persulphate level.
1 ex, 1 tbl
SUBSTANCE: invention relates to a compound of formula (II-A) or pharmaceutically acceptable salt thereof: [in which symbols denote the following: R10-R12: are identical or different and each denotes halogen, lower alkyl, halogen-lower alkyl, -OR0, -O-halogen-lower alkyl or -CN, R13: R0, halogen, halogen-lower alkyl, -OR0, -O-halogen-lower alkyl or -CN, ring B: benzene ring or a 5-6-member heteroaromatic ring containing 1-2 heteroatoms selected from O, S and N, R14: R0, halogen or -OR0, R0: are identical or different and each denotes H or lower alkyl, Y1: a single bond, lower alkylene, lower alkenylene or O-lower alkylene-, and Z1: -CO2R0 or -C0-NH-SO2-lower alkyl]. The invention also relates to a pharmaceutical composition based on the said compound, having antagonistic effect on the EP1 receptor.
EFFECT: obtaining novel compounds and a pharmaceutical composition based on said compounds, which can be used in a medicinal agent for treating lower urinary tract symptoms.
6 cl, 56 tbl, 231 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to chemical-pharmaceutical industry and deals with pharmaceutical composition of tablet, based on matrix, which contains alfozosin hydrochloride, polyvinylpyrrolidone, lactose and mixture HPMC K100, HPMC K100M and HPMC K15M, with controlled release.
EFFECT: form of tablet implementation ensures simplicity of tablet manufacturing and acceptable profile of alfuzosin release.
10 cl, 1 ex
SUBSTANCE: for experimental proliferative process inhibition in prostate tissues, the endoliquor introduction of the estrogenic preparation Estradurine to senior male rats in weight 200-250 g is performed. The preparation is introduced in a single dosage 0.002 mg by a suboccipital puncture. On the 10th day, the rats are decapitated for prostate examination.
EFFECT: under the conditions of the endoliquor introduction of Estradurine in specified dosages, the method provides greater proliferative activity inhibition in prostate cells, in comparison with the intramuscular introduction of estrogen, reduced synthetic activity of nucleic acids of prostate cells in the absence of weight reduction in experimental animals.
FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to chemical-pharmaceutical industry, and deals with medication for prevention and treatment of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS), associated with BPH, which contains formula (1) compound, and relaxant for relaxation of unstriped urethra muscles and unstriped prostatic muscles, which contains formula (I) compound.
EFFECT: medication can by means of nitrogen oxide ensure suppression of PDE-5 activity, which destroys c-GMP, and ensures nitrogen oxide-mediated relaxation of urethra unstriped muscles or prostatic gland unstriped muscles with reduction of intraurethral pressure (UP), thus ensuring treatment of BPH and LUTS, associated with BPH; in addition, time, necessary for achieving maximal concentration in blood is shorter and period of semiejection is longer in comparison with other PDE-5 inhibitors, therefore, introduction factor is lower, and medication in the invention, which demonstrates fewer side effects, can be efficiently used as safe medication.
27 cl, 5 ex, 3 tbl, 4 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmacy, namely to a pharmaceutical composition for local application, containing enzyme hyaluronidase which can be used in pharmacy for treatment and prevention of inflammatory prostate diseases, such as prostatitis. The pharmaceutical composition for local application contains as an active ingredient hyaluronidase 2.44 wt %, Tween-80 2.93 wt %, PEG-1500 91.69 wt %, liposome 2.44 wt %, and pharmaceutically acceptable carriers or excipients, such as benzydamine 0.5 wt %.
EFFECT: invention provides treatment and prevention of inflammatory prostate diseases, such as prostatitis.
1 tbl, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to chemical-pharmaceutical industry, namely to development of an anti-inflammatory and antibacterial drug representing a dry polyextract containing dry extracts of the following herbal raw material: Indian kidney tea (leaves), bearberry (leaves), knotgrass (herb), pot marigold (blossom), Ural licorice (root).
EFFECT: drug is effective for treatment and prevention of prostatitis.
SUBSTANCE: invention relates to medicine and can be used for manufacturing product for treatment or prevention of benign hypertrophy of prostate and/or erectile dysfunction in mammals. Product is obtained by fermentation of food material, which contains animal milk, in presence of at least one strain of Lactobacilli. Obtained milk serum is used for treatment or prevention of said pathology.
EFFECT: application of said product also ensures blockade of α1A-adrenoreceptors, which, in turn, results in reduction of tone of prostate unstriped muscles and bladder outlet.
31 cl, 2 dwg, 8 tbl, 10 ex
SUBSTANCE: invention is referred to the area of medicine and can be used for treatment of herpes hepatitis in children. The antiviral drugs prescribed included acyclovir (zovirax), valtrex, Isoprinosine, immunomodulatory drugs viferon, licopid, amixin, as well as ursodeoxycholic acid drugs, phosphogliv and viferon. Three different treatment protocols are used depending on the age. Doses, regimen and duration of exposure are established by protocols.
EFFECT: decreased terms of treatment; prevented development of complications; method can be used in out-patient setting.