Aspartic protease diaminoalkane inhibitors

FIELD: chemistry.

SUBSTANCE: compounds can be used to treat such diseases as hypertension, congestive heart failure, cardiac hypertrophy and others. In formula I R1 denotes a) cyclohexyl or trifluoromethyl; or b) phenyl, 2-thienyl, 3-thienyl, 2-pyridyl, 2-imidazolyl, 2-thiazolyl, 2-benzothienyl, 4-benzofuryl, 4-benzothienyl, 7-benzofuryl, 2,3-dihydro-7-benzofuryl, 7-benzothienyl, 1,3-benzodioxol-4-yl, 7-indazolyl, or 8-quinolinyl, optionally substituted with 1-3 substitutes, and X and Y each denotes a single bond; R2 denotes methyl, ethyl, propyl, butyl, pentyl, hexyl, 5-pentenyloxy, 3,33-trifluoropropyl, 4,4-difluoropentyl, 3-(cyclopropyl)propyl, 4-(cyclopropyl)butyl, 3-hydroxypropyl, 4-hydroxybutyl, 4-hydroxypentyl, 4-hydroxyhexyl, 5-hydroxyhexyl, 2-hydroxyethoxy etc, given in the claim; R3 denotes H, F, OH, methoxy, ethoxy, 3-hydroxypropoxy, acetylamino, propionylamino, (2-methylpropionyl)amino, or butanoylamino; A denotes 2,4-disubstituted morpholine with R1XCR2R3Y, bonded on the second position and Q bonded on the fourth position, 1,3-disubstituted piperidine with R1XCR2R3Y bonded on the third position and Q bonded on the first position, 1,3-dibustituted-3-methylpiperidine with R1XCR2R3Y bonded on the third position and Q bonded on the first position, 1,3-disubstituted benzene or 1,3-disubstituted cyclohexane; Q denotes Q1, Q2, Q4, Q5, Q9, or Q10 given in the claim, to which A and N are bonded on cut-off bonds, R4 denotes H or methyl.

EFFECT: obtaining novel compounds having aspartic protease inhibitor properties, particularly renin inhibitor.

10 cl, 1 tbl, 166 ex

 

The text descriptions are given in facsimile form.

1. The compound of the Formula I

where R1is a) cyclohexyl or trifluoromethyl; or b) phenyl, 2-thienyl, 3-thienyl, 2-pyridyl, 2-imidazolyl, 2-thiazolyl, 2-benzothiazyl, 4-benzofuran, 4-benzothiazyl, 7-benzofuran, 2,3-dihydro-7-benzofuran, 7-benzothiazyl, 1,3-benzodioxol-4-yl, 7-indazole or 8-chinoline, optionally substituted with from 1 to 3 substituents independently chosen from:
fluorine, chlorine, bromine, cyano, methyl, ethyl, isopropyl, tert-butyl, isobutyl, trifloromethyl, allyl, cyclohexyl, cyclohexen-1-yl, cyclopropylethyl, methoxy, triptoreline, neopentylene, methylthio, allyloxy, cyclopropylmethoxy, 2-(cyclopropyl)ethoxy, cyclopentyloxy cyclopentyloxy, benzyloxy, hydroxyl, aminocarbonyl, methoxycarbonyl, phenyl, phenoxy and 3 pyridyloxy, where phenyl, phenoxy, benzyloxy and 3 pyridyloxy group optionally substituted with 1 to 3 substituents independently selected from fluorine, chlorine, cyano, methyl, ethyl, trifloromethyl and aminocarbonyl;
X and Y each represents a simple bond;
R2represents methyl, ethyl, propyl, butyl, pentyl, hexyl, 5-pentyloxy, 3,3,3-cryptochromes, 4,4-differentil,
3-(cyclopropyl)propyl, 4-(cyclopropyl)butyl, 3-hydroxypropyl,
4-hydroxybutyl, 4-hydroxyphenyl, 4-hydroxyhexyl, 5-hydroxyhexyl,
2 hydroxyethoxy, 3-methoxypropyl, 3-ethoxypropan, 4-methoxybutyl,
4-ethoxymethyl, 2-(ethoxy)ethoxy, 3 methoxypropane, 3 ethoxypropane,
3 propoxyphene, 2-cyclopropylmethoxy, (2-(methoxy)ethoxy)methyl,
3-(acetylamino)propyl, 3-(propionamido)propyl,
3-(butenolide)propyl, 3-((2-methoxypropyl)amino)propyl,
3-(cyclopropanecarbonyl)propyl, 3-(triptorelin)propyl,
3-(methylaminoquinoline)propyl,
3-(dimethylaminocarbonylmethyl)propyl, 2-(acetylamino)ethoxy,
2-(propionamido)ethoxy, ethoxymethylenemalononitrile,
3-(aminosulfonyl)propyl or 3-(methanesulfonamido)propyl;
R3represents H, F, HE, methoxy, ethoxy, 3 hydroxypropoxy, acetylamino, propionamido (2-methylpropionyl)amino or butanolide; provided that when R3represents F or HE R2is not 2-ethoxyethoxy, 3 methoxypropane, 3 ethoxypropane, 3 propoxyphene or 2-cyclopropylmethoxy, 2-(acetylamino)ethoxy or 2-(propionamido)ethoxy;
Rather it represents a 2,4-disubstituted morpholine with R1XCR2R3Y attached to 2-position and Q attached at the 4-position, 1,3-disubstituted piperidine with R1XCR2R3Y attached at the 3-position and Q attached at the 1-position, 1,3-disubstituted-3-methylpiperidin with R1XCR2R3Y attached at the 3-position and Q attached at the 1-position, 1,3-disubstituted benzene or 1,3-disubstituted cyclohexane;
Q represents Q1, Q2, Q4, Q5, Q9, or Q10

where a and N are attached to the truncated relations;
R4represents H or methyl;
L represents a C2the alkyl chain in which one hydrogen atom optionally substituted with a group selected from R5;
L is optionally substituted with R6;
R6absent or represents methyl or hydroxymethyl;
R5represents methyl, isobutyl, tert-butylmethyl,
2,2,2-crypto is ethyl, 2-(trifluoromethyl)propyl, cyclopropylmethyl, cyclopentylmethyl, cyclohexylmethyl, 2-(cyclohexyl)ethyl,
(3-lordamantr)methyl, (3,3-diversilobum)methyl,
(3,4-diverticulitis)methyl, 4,4-diverticulectomy,
(4-methylcyclohexyl)methyl, tert-butoxymethyl,
(2-tetrahydrofuranyl)methyl, (2-tetrahydropyranyl)methyl,
(4-tetrahydropyranyl)methyl, (3-methoxycyclohexyl)methyl,
(4-methoxycyclohexyl)methyl, benzyl, phenethyl,
(1-forcelogix)methyl, (4-forcelogix)methyl,
1-hydroxy-2-methylpropyl, (cyclopentyl)(hydroxy)methyl,
(cyclohexyl)(hydroxy)methyl, (4-forcelogix)(hydroxy)methyl,
(cycloheptyl)(hydroxy)methyl, (1-hydroxycyclohexyl)methyl,
(4-hydroxycyclohexyl)methyl, (4-hydroxy-4-methylcyclohexyl)methyl,
(3-lordamantr)(hydroxy)methyl, 2-methoxy-2-methylpropyl or
2,2-dimethyl-3-methoxypropyl;
G represents NH2, Other9or NR9R10;
R9represents methyl, ethyl, propyl, butyl, isobutyl, pentyl, isopentyl, aminocarbonylmethyl, or R9together with R5represent -(CH2)3-, -(CH2)4-, -(CH2)2SN(Deut.-hexyl)-, or -(CH2)2SN(cos(C2H5)2)-;
R10represents methyl;
provided that when R2represents methyl, ethyl, propyl, butyl, pentyl or hexyl and R 3HE is a, R6no;
or enantiomers, diastereomers, and pharmaceutically acceptable salts.

2. The compound according to claim 1 of the Formula IIa:
,
where Z represents CH2or;
R1is a) cyclohexyl or trifluoromethyl; or b) phenyl, 2-thienyl, 3-thienyl, 2-pyridyl, 2-imidazolyl or 2-thiazolyl, optionally substituted with from 1 to 3 substituents independently chosen from:
fluorine, chlorine, bromine, cyano, methyl, ethyl, isopropyl, trifloromethyl, allyl, cyclopropylmethyl, methoxy, triptoreline, neopentylene, methylthio, allyloxy, cyclopropylmethoxy, 2-(cyclopropyl)ethoxy, cyclopentyloxy, cyclopentyloxy, benzyloxy, hydroxyl, aminocarbonyl, methoxycarbonyl, phenyl, phenoxy, benzyloxy, 3-pyridyloxy, where phenyl and phenoxy, benzyloxy and 3 pyridyloxy group optionally substituted with 1 to 3 substituents independently selected from fluorine, chlorine, cyano, methyl, ethyl and trifloromethyl;
or C) 2-benzothiazyl, 4-benzofuran, 4-benzothiazyl, 7-benzofuran, 2,3-dihydro-7-benzofuran, 7-benzothiazyl, 1,3-benzodioxol-4-yl, 7-indazole or 8-chinoline, optionally substituted with from 1 to 3 substituents independently selected from fluorine, methyl, isobutyl and tert-butyl;
R2represents methyl, ethyl, propyl, butyl, hexyl,
3,3,3-cryptochromes, 4,4-differentil, 3-(cyclopropyl)propyl,
4-(cyclopropyl)butyl, 3-hydroxypropyl, 4-hydroxybutyl,
4-hydroxyphenyl, 4-hydroxyhexyl, 5-hydroxyhexyl, 2-hydroxyethoxy,
3-ethoxypropan, 4-methoxybutyl, 4-ethoxymethyl, 2-(ethoxy)-ethoxy,
3 methoxypropane, 3 propoxyphene, 2-cyclopropylmethoxy,
(2-(methoxy)ethoxy)methyl, 3-(acetylamino)propyl,
3-(propionamido)propyl, 3-(butenolide)propyl,
3-((2-methoxypropyl)amino)propyl,
3-(cyclopropanecarbonyl)propyl, 3-(triptorelin)propyl,
3-(methylaminoquinoline)propyl,
3-(dimethylaminocarbonylmethyl)propyl, ethoxymethylenemalononitrile, or
3-(aminosulfonyl)propyl;
R3represents H, F, HE, methoxy, 3-hydroxypropoxy, acetylamino, propionamido, (2-methylpropionyl)amino or butanolide;
provided that when R3represents F or HE R2is not 3-methoxypropane, 3 ethoxypropane, 3 propoxyphene or 2-cyclopropylmethoxy;
R5represents methyl, isobutyl, tert-butylmethyl,
2,2,2-triptorelin, 2-(trifluoromethyl)propyl, cyclopropylmethyl, cyclopentylmethyl, cyclohexylmethyl, 2-(cyclohexyl)ethyl,
(3-lordamantr)methyl, (3,3-diversilobum)methyl,
(3,4-diverticulitis)methyl, 4,4-diverticulectomy,
(4-methylcyclohexyl)methyl, tert-butoxymethyl,
(4-tetrahydropyranyl)methyl, (3-methoxycyclohexyl)methyl,
(4-methoxycyclohexyl)methyl, benzyl, phenethyl,
(1-forcelogix)methyl, (4-forcelogix)methyl, 1-hydroxy-2-methylpropyl, (cyclopentyl)(hydroxy)methyl, (cyclohexyl)(hydroxy)methyl,
(4-forcelogix)(hydroxy)methyl, (cycloheptyl)(hydroxy)methyl,
(1-hydroxycyclohexyl)methyl,
(4-hydroxycyclohexyl)methyl, (3-lordamantr)(hydroxy)methyl or
2-methoxy-2-methylpropyl;
or its pharmaceutically acceptable salt.

3. The compound of Formula IIb:

where Z represents CH2or;
R1is a) cyclohexyl or trifluoromethyl; or b) phenyl, 2-thienyl, 3-thienyl, 2-pyridyl, 2-imidazolyl, or 2-thiazolyl, optionally substituted with from 1 to 3 substituents independently chosen from:
fluorine, chlorine, bromine, cyano, methyl, ethyl, isopropyl, trifloromethyl, allyl, cyclopropylmethyl, methoxy, triptoreline, neopentylene, methylthio, allyloxy, cyclopropylmethoxy, 2-(cyclopropyl)ethoxy, cyclopentyloxy, cyclopentyloxy, benzyloxy, hydroxyl, aminocarbonyl, methoxycarbonyl, phenyl, phenoxy, benzyloxy and 3 pyridyloxy, where phenyl and phenoxy, benzyloxy and pyridyloxy, optionally substituted with from 1 to 3 substituents independently selected from fluorine, chlorine is, cyano, methyl, ethyl and trifloromethyl;
or C) 2-benzothiazyl, 4-benzofuran, 4-benzothiazyl, 7-benzofuran,
2,3-dihydro-7-benzofuran, 7-benzothiazyl, 1,3-benzodioxol-4-Il,
7-indazole or 8-chinoline, optionally substituted with from 1 to 3 substituents independently selected from fluorine, methyl, isobutyl and tert-butyl;
R2is a (C1-C8)alkyl, (C4-C8)cycloalkenyl, fluorine(C1-C8)alkyl, fluoro(C4-C8)cycloalkenyl, (C1-C8)alkoxy, (C4-C8)cycloalkylcarbonyl, fluorine(C1-C8)alkoxy, hydroxy(C1-C8)alkyl, (C1-C5)alkoxy(C1-C5)alkyl, (C1-C5)alkoxy(C1-C5)hydroxyalkyl, (C3-C4)cycloalkane(C1-C5)alkyl, fluoro(C1-C5)alkoxy(C1-C5)alkyl, fluoro(C3-C4)cycloalkane(C1-C5)alkyl, (C1-C5)alkylthio(C1-C5)alkyl, (C1-C5)alkoxy(C1-C5)alkoxy, hydroxy(C1-C8)alkoxy, (C3-C4)cycloalkane(C1-C5)alkoxy, fluorine(C1-C5)alkoxy(C1-C5)alkoxy, fluorine(C3-C4)cycloalkane(C1-C5)alkoxy, (C1-C3)alkoxy(C1-C3)alkoxy(C1-C3)alkyl, fluoro(C1-C3)alkoxyl 1-C3)alkoxy(C1-C3)alkyl, aminocarbonyl(C1-C8)alkyl, aminocarbonyl(C1-C8)alkoxy, (C1-C5)alkanolamine(C1-C5)alkyl, (C1-C5)alkanolamine(C1-C5)alkoxy, fluorine(C1-C5)alkanolamine(C1-C5)alkyl, fluoro(C1-C5)alkanolamine(C1-C5)alkoxy,
(C1-C3)alkoxy(C1-C5)alkanolamine(C1-C5)alkyl,
(C1-C3)alkoxy(C1-C5)alkanolamine(C1-C5)alkoxy,
(C3-C4)cycloalkylcarbonyl(C1-C5)alkyl,
(C3-C4)cycloalkylcarbonyl(C1-C5)alkoxy, aminosulfonyl(C1-C8)alkyl, aminosulfonyl(C1-C8)alkoxy, (C1-C5)alkanesulfonyl(C1-C5)alkyl,
(C1-C5)alkanesulfonyl(C1-C5)alkoxy,
(C1-C5)alkylaminocarbonyl(C1-C5)alkyl,
di(C1-C5)alkylaminocarbonyl(C1-C5)alkyl,
(C1-C5)alkylaminocarbonyl(C1-C5)alkoxy,
di(C1-C5)alkylaminocarbonyl(C1-C5)alkoxy,
R3represents H, F, HE, (C1-C4)alkanolamine or (C1-C3)Alcock and;
provided that when R3HE is a or F, R2is not (C2-C10)alkoxy, (C4-C10)cycloalkylcarbonyl, halogen(C2-C10)alkoxy, (C2-C10)alkylthio, halogen(C2-C10)alkylthio, (C1-C5)alkoxy(C1-C5)alkoxy, hydroxy(C2-C10)alkoxy, (C3-C6)cycloalkane(C1-C5)alkoxy, halogen(C1-C5)alkoxy(C1-C5)alkoxy, halogen(C3-C6)-cycloalkane(C1-C5)alkoxy, hydroxy(C2-C10)alkylthio, (C2-C5)alkoxy(C1-C5)alkylthio, (C1-C5)alkyl-thio(C1-C5)alkoxy or (C1-C5)alkylthio(C1-C5)alkylthio,
(C3-C4)cycloalkylcarbonyl(C1-C5)alkoxy,
(C3-C4)cycloalkylcarbonyl(C1-C5)alkylthio,
(C1-C5)alkylaminocarbonyl(C1-C5)alkoxy,
(C1-C5)alkylaminocarbonyl(C1-C5)alkylthio,
di(C1-C5)alkylaminocarbonyl(C1-C5)alkoxy or
di(C1-C5)alkylaminocarbonyl(C1-C5)alkylthio;
Q represents Q1, Q2, Q4, Q5, Q9, or Q10

where a and N are attached to the truncated relations,
R4represents H or (C1-C3)alkyl;
R6represents (a) (C1-C10)alkyl, (C4-C10)cycloalkenyl, halogen(C1-C10)alkyl, hydroxy(C1-C10)alkyl, halogen(C4-C10)cycloalkenyl, gidroksilirovanii (C4-C10)cycloalkenyl, (C1-C2)alkyl(C4-C10)cycloalkenyl, di(C1-C2)alkyl(C4-C10)cycloalkenyl, gidroksilirovanii (C1-C2)alkyl(C4-C10)cycloalkenyl, gidroksilirovanii di(C1-C2)alkyl(C4-C10)cycloalkenyl, (C4-C10)bicycloalkyl(C1-C2)alkyl, (C8-C12)tricyclohexyl(C1-C2)alkyl, (C1-C5)alkoxy(C1-C5)alkyl, halogen(C1-C5)alkoxy(C1-C5)alkyl, (C1-C5)alkylthio(C1-C5)alkyl, halogen(C1-C5)alkylthio(C1-C5)alkyl, or saturated heterocyclyl(C1-C3)alkyl; or b) phenyl(C1-C2)alkyl or heteroaryl(C1-C2)alkyl, each optionally substituted with 1 to 3 groups independently selected from
fluorine, chlorine, cyano, (C1-C3)alkyl halogen(C 1-C3)alkyl, (C1-C3)alkoxy and halogen(C1-C3)alkoxy;
G represents NH2, Other9or NR9R10;
R9represents (a) (C1-C6)alkyl, halogen(C1-C6)alkyl, (C4-C10)cycloalkenyl, (C1-C5)alkoxy(C1-C5)alkyl, or aminocarbonyl(C1-C6)alkyl; or b) phenyl(C1-C2)alkyl, optionally substituted with from 1 to 3 groups independently selected from:
fluorine, chlorine, cyano, (C1-C3)alkyl, halogen(C1-C3)alkyl, (C1-C3)alkoxy and halogen(C1-C3)alkoxy; or
(C) R6and R9together represent -(CH2)2-, -(CH2)3- or -(CH2)4and form a 4-, 5-, 6 - or 7-membered ring with the atoms through which they are associated;
R10is a (C1-C3)alkyl or halo(C1-C3)alkyl; and pharmaceutically acceptable salts.

4. The compound according to claim 3, where R9is a (C1-C6)alkyl, (C1-C5)alkoxy(C1-C5)alkyl or aminocarbonyl(C1-C6)alkyl.

5. The compound according to claim 3, where R6is a (C1-C6)alkyl, hydroxy(C1-C10)alkyl.

6. The compound according to claim 1, where the compound represented by the formula:

R1is a) cyclohexyl or b) phenyl, optionally substituted with from 1 to 3 substituents independently chosen from:
fluorine, chlorine, cyano, methyl, ethyl, isopropyl, trifloromethyl, allyl, cyclopropylmethyl, phenyl, phenoxy, where phenyl and fenoxaprop optionally substituted with from 1 to 3 substituents independently selected from fluorine, chlorine, cyano, methyl and trifloromethyl;
R2represents a butyl, hexyl, 3,3,3-cryptochromes,
3-(cyclopropyl)propyl, 4-(cyclopropyl)butyl, 3-ethoxypropan,
4-methoxybutyl, 4-ethoxymethyl, 3 methoxypropane, 3 ethoxypropane,
3 propoxyphene or 2-cyclopropylmethoxy;
R3represents H, F or HE;
provided that when R3represents F or HE R2is not
3 methoxypropane, 3 ethoxypropane, 3 propoxyphene or
2 cyclopropylmethoxy;
Q represents Q1, Q4, Q9 or Q10

where a and N are attached to the truncated relations,
R4represents H or methyl;
R5represents methyl, isobutyl, 2-(trifluoromethyl)propyl, cyclopentylmethyl, cyclohexylmethyl, 4,4-diverticulectomy, tert-butoxymethyl or benzyl;
G represents NH2, Other9or NR9Rsup> 10;
R9represents methyl, ethyl, propyl, butyl, isobutyl, pentyl, or isopentyl, or aminocarbonylmethyl; or R9together with R5represents -(CH2)3-;
R10represents methyl;
and its pharmaceutically acceptable salts.

7. The compound according to claim 1, selected from the group including:
N-(1-amino-3-cyclohexylprop-2-yl)-3-(1-hydroxy-1-fenilpentil)piperidine-1-carboxamide;
3-((3-methoxypropane)(phenyl)methyl)-N-(1-amino-3-cyclohexylprop-2-yl)benzamide;
3-((2-cyclopropylmethoxy)(phenyl)methyl)-N-(1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
N-(1-amino-3-cyclohexylprop-2-yl)-3-(5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
3-((3-methoxypropane)(phenyl)methyl)-N-(1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
3-((3-methoxypropane)(phenyl)methyl)-N-(2-amino-3-cyclohexylprop)piperidine-1-carboxamide;
N-(1-amino-3-cyclopentylpropionic-2-yl)-3-(1-hydroxy-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
2-((3-methoxypropane)(phenyl)methyl)-N-(1-amino-3-cyclohexylprop-2-yl)morpholine-4-carboxamide;
N-(3-tert-butoxy-1-aminopropan-2-yl)-3-(1-hydroxy-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
3-(1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-((3-methoxypropane)(phenyl)methyl)-N-(3-cyclohexyl-1-(methylamino)the PCC is n-2-yl)benzamide;
N-(1-amino-3-phenylpropane-2-yl)-3-(1-hydroxy-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
N-(1-amino-3-cyclohexylprop-2-yl)-3-(1-hydroxy-1-phenylheptane)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
N-(1-amino-3-cyclohexylprop-2-yl)-3-(5-ethoxy-1-fenilpentil)piperidine-1-carboxamide;
3-((3-methoxypropane)(phenyl)methyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((3-ethoxypropane)(phenyl)methyl)-N-(1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
N-(1-amino-3-cyclohexylprop-2-yl)-3-(1-hydroxy-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
3-((3-methoxypropane)(phenyl)methyl)-N-(1-amino-3-cyclohexylprop-2-yl)-N-methylpiperidin-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-4-methoxy-1-phenylbutyl)piperidine-1-carboxamide;
3-((3-methoxypropane)(4-forfinal)methyl)-N-(1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
3-((3-methoxypropane)(2-forfinal)methyl)-N-(1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-cyclohexyl-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(4-cyclopropyl-1-hydroxy-1-phenylbutyl)piperidine-1-carboxamide;
3-((3-methoxypropane)(3-cyanophenyl)methyl)-N-(1-amino-3-cyclohexylprop the EN-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(5-ethoxy-1-fenilpentil)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-fenilpentil)cyclohexanecarboxylic;
N-(1-amino-4-(trifluoromethyl)pentane-2-yl)-3-(1-hydroxy-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
3-((3-methoxypropane)(phenyl)methyl)-N-(3-cyclohexyl-1-(ethylamino)propan-2-yl)piperidine-1-carboxamide;
N-(1-cyclohexyl-3-(methylamino)propan-2-yl)-3-((3-ethoxypropane)(phenyl)methyl)piperidine-1-carboxamide;
N-(1-amino-3-cyclohexylprop-2-yl)-3-(5-ethoxy-1-hydroxy-1-fenilpentil)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
3-((3-ethoxypropane)(phenyl)methyl)-N-(1-amino-3-cyclohexylprop-2-yl)-3-methylpiperidin-1-carboxamide;
N-(2-amino-5-methoxy-4,4-dimethylpentyl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(3-forfinal)-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-cyclohexyl-3-(methylamino)propan-2-yl)-3-(1-fluoro-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
3-((3-methoxypropane)(3-forfinal)methyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(1-amino-3-cyclohexylprop-2-yl)-3-(1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-(methylamino)propan-2-yl)-3-(1-cyclohexyl-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-((3-methoxypropane)(2,4-differenl)methyl)-N-(1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
3-((3-methoxypropane)(3,4-differenl)methyl)-N-(1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((3-methoxypropane)(3-cyanophenyl)methyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((3-methoxypropane)(2-allylphenol)methyl)-N-(1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
3-((3-methoxypropane)(phenyl)methyl)-N-(3-cyclohexyl-1-(propylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(5-ethoxy-1-hydroxy-1-fenilpentil)piperidine-1-carboxamide;
3-((3-propoxyphene)(phenyl)methyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-m-carpenter)piperidine-1-carboxamide;
N-(1-amino-5-methoxy-4,4-dimethylpentan-2-yl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N2-((Z)-1-(3-((3-methoxypropane)(phenyl)methyl)piperidine-1-yl)-2-nitrovinyl)-3-cyclohexylprop-1,2-diamine;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(2-amino-5-methoxy-4,4-dimethylpentyl)-3-(1-(2,3-differenl)-1-hydroxy-5-ketoxime the Teal)piperidine-1-carboxamide;
3-(1-amino-3-cyclohexylprop-2-ylamino)-4-(3-((2-cyclopropylmethoxy)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)-N-(piperidine-3-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(4,4,4-Cryptor-1-hydroxy-1-m-tributyl)piperidine-1-carboxamide;
3-(1-amino-3-cyclohexylprop-2-ylamino)-4-(3-((3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-(1-amino-3-cyclohexylprop-2-ylamino)-4-(2-((3-methoxypropane)(phenyl)methyl)morpholino)cyclobuta-3-ene-1,2-dione;
4-(3-((3-methoxypropane)(phenyl)methyl)piperidine-1-yl)-N-(1-amino-3-cyclohexylprop-2-yl)-1,2,5-thiadiazole-3-amine;
3-((3-methoxypropane)(phenyl)methyl)-N-(1-(butylamino)-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
3-((3-methoxypropane)(phenyl)methyl)-N-(3-cyclohexyl-1-(isobutylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(dimethylamino)propan-2-yl)-3-(5-ethoxy-1-hydroxy-1-fenilpentil)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((3-ethoxypropane)(3,4-differenl)methyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(2,5-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-(4,4-diverticulosis)-1-(methylamino)the PCC is n-2-yl)-3-(1-hydroxy-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(3,4-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-amino-3-cyclohexylprop-2-ylamino)-4-(3-(1-hydroxy-1-phenylheptane)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-(3-amino-1-cyclohexylmethyl-2-ylamino)-4-(3-((3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-(3-cyclohexyl-1-(methylamino)propane-2-ylamino)-4-(3-((3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-(1-(2-(p-tolyloxy)-5-were)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(3-((3-methoxypropane)(phenyl)methyl)piperidine-1-yl)-4-(N-(1-amino-3-cyclohexylprop-2-yl)-N-methylamino)cyclobuta-3-ene-1,2-dione;
3-((3-methoxypropane)(2-(trifluoromethyl)phenyl)methyl)-N-(1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
3-(1-amino-3-cyclohexylprop-2-ylamino)-4-(3-((3-methoxypropane)(4-forfinal)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-(1-amino-3-cyclohexylprop-2-ylamino)-4-(3-((3-methoxypropane)(2-forfinal)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-((3-methoxypropane)(phenyl)methyl)-N-(3-cyclohexyl-1-(isobutylamino)propan-2-yl)piperidine-1-carboxamide;
3-((3-methoxypropane)(phenyl)methyl)-N-(3-cyclohexyl-1-(pentylamine)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-1-(3-isopropylphenyl)-5-methoxyphenyl)is piperidin-1-carboxamide;
3-(1-(3-chlorophenyl)-4,4,4-Cryptor-1-hydroxybutyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(5-chloro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-5-cyclopropyl-1-hydroxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((3-methoxypropane)(2-phenylphenyl)methyl)-N-(2-amino-3-cyclohexylprop)piperidine-1-carboxamide;
3-((3-methoxypropane)(2-(2-cyclopropylethyl)phenyl)methyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(3-cyclohexyl-1-(ethylamino)propane-2-ylamino)-4-(3-((3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
N-(1-amino-5-methoxy-4,4-dimethylpentan-2-yl)-3-(1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)-3-(1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-amino-3-cyclohexylprop-2-ylamino)-4-(3-((3-methoxypropane)(2,4-differenl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-(1-amino-3-cyclohexylprop-2-ylamino)-4-(3-((3-methoxypropane)(3,4-differenl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
N-(1-(carbamoylmethyl)-3-cyclohexylprop-2-yl)-3-(1-(3-forfinal)-1-hydro is C-5-methoxyphenyl)piperidine-1-carboxamide;
3-(3-cyclohexyl-1-(propylamino)propane-2-ylamino)-4-(3-((3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(3-(trifluoromethyl)phenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(3-cyclohexyl-1-(isobutylamino)propane-2-ylamino)-4-(3-((3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-(3-(butylamino)-1-cyclohexylprop-2-ylamino)-4-(3-((3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-(1-(2-(p-tolyloxy)-5-were)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(5-chloro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(3-cyclohexyl-1-(methylamino)propane-2-ylamino)-4-(3-((3-ethoxypropane)(3,4-differenl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-(1-amino-3-cyclohexylprop-2-ylamino)-4-(3-((3-methoxypropane)(2-(trifluoromethyl)phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxamide;
3-(1-cyclohexyl-3-(pentylamine)propane-2-ylamino)-4-(3-((3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-(1-cyclohexyl-3-(isobutylamino)propane-2-ylamino)-4-(3-((3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
-(1-(2-(p-tolyloxy)-5-were)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(5-chloro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(Penta-4-enyloxy)(phenyl)methyl)benzamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(5-methoxy-1-fenilpentil)benzamide;
3-((2-ethoxyethoxy)(phenyl)methyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)benzamide;
3-(1-(2-(cyclopropylmethoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((S)-1-hydroxy-5-methoxy-1-m-carpenter)-N-(4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(5-methoxy-1-(thiophene-2-yl)pentyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1,1,1-Cryptor-2-hydroxy-6-meloxicam-2-yl)piperidine-1-carboxamide;
3-((2-(acetylamino)ethoxy)(phenyl)methyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)benzamide;
3-(1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-fenilpentil)benzamide;
3-((3-ethoxypropane)(phenyl)methyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)benzamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(IU is ylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(benzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(pyridine-2-yl)pentyl)piperidine-1-carboxamide;
3-(1-(2-(2-cyclopropylmethoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(cyclopentyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((3-methoxypropane)(phenyl)methyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carbothioamide;
N-(1-amino-3-cyclohexylprop-2-yl)-3-(1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-hydroxy-5-methoxy-1-(2-(neopentylene)phenyl)pentyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(1-methyl-1H-imidazol-2-yl)pentyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(thiophene-2-yl)pentyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(thiophene-3-yl)pentyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-m-carpenter)benzamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-o-carpenter)benzamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydrox the-5-methoxy-1-(thiazol-2-yl)pentyl)piperidine-1-carboxamide;
3-(1-(2-(3-were)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(4-were)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(2-were)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-(4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(o-tolyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(2-amino-ethyl)-N-methylpiperidin-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)benzamide;
3-(1-hydroxy-5-methoxy-1-(quinoline-8-yl)pentyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(2-forfinal)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-phenyl-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(3-forfinal)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((S)-1-(2-(4-forfinal)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-hydroxy-5-methoxy-1-(2-methylbenzofuran-7-yl)pentyl)-N-(4-methyl-1-(methylamino)p is ntan-2-yl)piperidine-1-carboxamide;
3-(1-hydroxy-1-(2-isobutylbenzene-7-yl)-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-fenilpentil)-3-methylpiperidin-1-carboxamide;
3-(1-(2-(cyclopentyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(2-fluoro-5-were)-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(benzo[b]thiophene-7-yl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-((3-ethoxypropane)(3-forfinal)methyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(1-amino-3-cyclohexylprop-2-yl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-((3-ethoxypropane)(3-chlorophenyl)methyl)-N-(1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1,5-dihydroxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(5-methylthiazole-2-yl)pentyl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-methoxyphenyl)-N-(3-cyclohexyl-1-hydroxypropan-2-yl)piperidine-1-carboxamide;
3-((3-methoxypropane)(4-chloropyridin-2-yl)methyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)-N-(2-methyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(o-tolyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(m-tolyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-(3,3-diversilobum)-1-(methylamino)propan-2-yl)-3-(1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-((S)-1-(benzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)benzamide;
3-(1-(2-(4-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(5-fluoro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(3-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(2-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclopentyl-1-(methylaminopropane-2-yl)-3-((S)-1-(2,3-dihydrobenzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(2,5-dimetilfenil)pentyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(3-ethylphenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(2,3-dimetilfenil)pentyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(3, 5dimethylphenyl)pentyl)piperidine-1-carboxamide;
3-(1-(2-(2-chlorophenyl)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-phenylphenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(3-methoxyphenyl)pentyl)piperidine-1-carboxamide;
3-(1-(2-(cyclopropylmethoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-4-cyclopropyl-1-hydroxybutyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(3-fluoro-5-were)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(2-fluoro-5-were)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(5-fluoro-2-were)-1-hydroxy-5-ketoxime who yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(2-fluoro-3-were)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-(1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-((S)-1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(3-(1-hydroxycyclohexyl)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(3-(1-hydroxycyclohexyl)-2-(methylamino)propyl)piperidine-1-carboxamide;
3-((3-ethoxypropane)(3-chlorophenyl)methyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1,5-dihydroxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(4-chloropyridin-2-yl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((3-ethoxypropane)(phenyl)methyl)-N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(3,5-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-cyclopentyl-1-(methylamino)propan-2-yl)-3-(5-ethoxy-1-(2,3-differenl)-1-HYDR is xipanel)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(2-phenylphenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-(tetrahydro-2H-Piran-4-yl)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
2-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)morpholine-4-carboxamide;
N-(3-amino-1-cyclohexyl-1-hydroxypropan-2-yl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclopentyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(o-tolyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(2-methyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(2-ethyleneoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(5-chloro-1-methyl-1H-imidazol-2-yl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2,2-debtorrent[d][1,3]dioxol-4-yl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxyethyl)-N-(1-cyclohexyl-3-(metelli is about)propan-2-yl)piperidine-1-carboxamide;
3-(1-(benzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-1-(1H-indazol-7-yl)-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-1-(1H-indazol-7-yl)-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(2-(4-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(2-methyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(3-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(2-methyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-(o-tolyloxy)-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(o-tolyloxy)-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(5-fluoro-2-methylphenoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(4-fluoro-2-methylphenoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(2,3-dihydrobenzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-(3,3-diversilobum)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-(3,3-diversilobum)-1-(methylamino)propan-2-yl)-3-(1-(2,3-differenl)--hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(2-(cyclopentyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(2-cyclopropylmethoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(2-chlorophenoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-hydroxy-5-methoxy-1-(2-(neopentylene)phenyl)pentyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(3-(methylthio)phenyl)pentyl)piperidine-1-carboxamide;
3-(4-(acetylamino)-1-(3-chlorophenyl)-1-hydroxybutyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(allyloxy)-5-forfinal)-5-ethoxy-1-hydroxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(5-fluoro-2-methoxyphenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(2-fluoro-6-methoxyphenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(4-cyclopropyl-1-hydroxy-1-(2-phenoxyphenyl)butyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(5,5,5-Cryptor-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1,5-dimethoxyphenyl)-N-(3-cyclohexyl-1-(METI is amino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(ethylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1,5-dihydroxyethyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(4-cyclopropyl-1-(3-forfinal)-1-hydroxybutyl)-N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-m-carpenter)piperidine-1-carboxamide;
3-((3-ethoxypropane)(m-tolyl)methyl)-N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(5-ethoxy-1-(2,3-differenl)-1-hydroxyphenyl)piperidine-1-carboxamide;
3-(1-(2-fluoro-3-were)-1-hydroxy-5-methoxyphenyl)-N-(3-(4-forcelogix)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclopropyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxamide;
3-(1-(2-(3-were)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(4-were)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-(1-hydroxycyclohexyl the l)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-(1-hydroxycyclohexyl)-2-(methylamino)propyl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carbothioamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(quinoline-8-yl)pentyl)piperidine-1-carboxamide;
3-(1-(2-(p-tolyloxy)-5-were)-1-hydroxy-5-methoxyphenyl)-N-(2-methyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-5-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-5-ethoxy-1-hydroxyphenyl)-N-(3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-(4-forcelogix)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((3-ethoxypropane)(3-forfinal)methyl)-N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(2,3,5-tryptophanyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-cyclopentyl-1-(methylamino)propan-2-yl)-3-(5-ethoxy-1-(2,3,5-tryptophanyl)-1-hydroxyphenyl)piperidine-1-carboxamide;
3-(1-(2-(2-ethyleneoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-g is droxy-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-fluoro-2-phenylphenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(2-forfinal)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(3-forfinal)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(4-forfinal)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-5,5-debtor-1-hydroxyhexyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((3-methoxypropane)(2,3-dichlorophenyl)methyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2,3-dichlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((3-ethoxypropane)(2,3-dichlorophenyl)methyl)-N-(3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(benzo[b]thiophene-7-yl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(benzo[b]thiophene-2-yl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-hydroxy-5-methoxy-1-(3-(triptoreline)phenyl)pentyl)-N-(4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(5-perbendaharaan-7-yl)-1-hydroxy-5-methoxy who enter)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N'-cyano-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamidine;
3-(1-acetamido-1-(3-forfinal)-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(3-(3,3-diversilobum)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(3-(trifluoromethyl)phenyl)-1-hydroxy-5-methoxyphenyl)benzamide;
3-(1-(2-(o-tolyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)-N-(4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(benzyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(m-tolyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-5-ethoxy-1-hydroxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)-3-(4-methylcyclohexyl)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(2-(trifluoromethyl)phenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(5-ethoxy-1-(2,3,5-three is terphenyl)-1-hydroxyphenyl)piperidine-1-carboxamide;
3-(1-(2-fluoro-3-were)-1-hydroxy-5-methoxyphenyl)-N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2,3-dichlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((3-ethoxypropane)(2,3-dichlorophenyl)methyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2,3-dichlorophenyl)-5-ethoxy-1-hydroxyphenyl)-N-(3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(4-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(5-fluoro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(3-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(2-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-fluoro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-(4-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((3-ethoxypropane)(3-chlorophenyl)methyl)-N-(3-(4,4-diverticulosis)1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(3-(4-forcelogix)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(2-chlorophenyl)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(4-chlorophenyl)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(3-chlorophenyl)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)-3-(1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
2-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)morpholine-4-carboxamide;
3-(1-acetamido-1-(3-chlorophenyl)-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(benzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(4,4,4-Cryptor-1-(methylamino)butane-2-yl)-3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxamide;
3-(1-(2-(2-(trifluoromethyl)phenoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(2,2-debtorrent[d][1,3]dioxol-4-yl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(2-(o-tolyloxy)-3-were)-1-Ki-the Roxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2,3-dichlorophenyl)-5-ethoxy-1-hydroxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(3-(triptoreline)phenyl)pentyl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(2-(triptoreline)phenyl)pentyl)piperidine-1-carboxamide;
3-(1-(2-(p-tolyloxy)-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(o-tolyloxy)-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(5-fluoro-2-methylphenoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-(4-fluoro-2-methylphenoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(2-(cyclopentyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(2-(2-cyclopropylmethoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(5-ethoxy-1-(2,3-differenl)-1-hydroxyphenyl)-N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(4-pertenece)-5-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((3-ethoxypropane)(3-chloro-2-forfinal)methyl)-N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-5-methoxy-1-(propionamido)pentyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)-3-(1-(2,3,5-tryptophanyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-((3-ethoxypropane)(2,3,5-tryptophanyl)methyl)-N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-(3,3-diversilobum)-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(3-(triptoreline)phenyl)pentyl)piperidine-1-carboxamide;
3-(1-(3-hydroxypropoxy)-1-(3-chlorophenyl)-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(2-(pyridine-3-yloxy)phenyl)pentyl)piperidine-1-carboxamide;
3-(1-acetamido-1-(3-chloro-2-forfinal)-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(allyloxy)-3-bromophenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-(isobutylamino)-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carb is camid;
3-(5-ethoxy-1-(2,3,5-tryptophanyl)-1-hydroxyphenyl)-N-(3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(5,5,5-Cryptor-4-methyl-1-(methylamino)pentane-2-yl)-3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxamide;
3-(1-(2-(benzyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-5-methoxy-1-(propionamido)pentyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(4-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-cyclohexyl-1-(methylamino)propan-2-yl)-3-(1-(5-fluoro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(2-(2-(trifluoromethyl)phenoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-(isobutylamino)-5-methoxyphenyl)-N-(3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxypropyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(1-cyclohexyl-3-(methylamino)propan-2-yl)-2-(5-methoxy-1-fenilpentil)morpholine-4-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxybutyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-cyclohexyl-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(METI is amino)propan-2-yl)benzamide;
3-(1-(3-chlorophenyl)-1-hydroxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-cyclohexyl-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1,4-dihydroxybutyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-hydroxy-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(benzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-(4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-tert-butylbenzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-amino-1-cyclohexylmethyl-2-yl)-3-(1-(2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-cyclopentyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-(1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(2-amino-3-cyclohexylprop)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(4-methoxy-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-cyanophenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-chloro-3-fluoro who enyl)-1-hydroxy-5-methoxyphenyl)-N-(4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(3-hydroxy-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(benzo[b]thiophene-4-yl)-1-hydroxy-5-methoxyphenyl)-N-(4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(4-acetamido-1-(2-forfinal)-1-hydroxybutyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(1-cyclohexyl-3-(methylamino)propan-2-yl)-3-(1-(3-fluoro-2-were)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-cyclohexyl-3-(methylamino)propan-2-yl)-3-(1-(3-fluoro-4-were)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-cyclohexyl-3-(methylamino)propan-2-yl)-3-(1-(3-fluoro-2-hydroxyphenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-(1-(2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-amino-1-cyclohexylmethyl-2-yl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-2-(methylamino)propyl)piperidine-1-carboxamide;
N-(1-(4-forcelogix)-3-(methylamino)propan-2-yl)-3-(1-(2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-cyclopentyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-(1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(2-chloro-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-CEC is opentel-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(2-amino-3-cyclohexylprop)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(benzofuran-4-yl)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(4-acetamido-1-(3, 5dimethylphenyl)-1-hydroxybutyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-cyclohexyl-1-hydroxy-5-methoxyphenyl)-N-(1-(4,4-diverticulosis)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(2-amino-3-cyclohexylprop)-3-(1-(benzo[b]thiophene-4-yl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(4-methoxy-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(2-cyano-5-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-carbamoylphenoxy)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(2-amino-3-cyclohexylprop)-2-(1-(benzo[b]thiophene-7-yl)-1-hydroxy-5-methoxyphenyl)morpholine-4-carboxamide;
3-(4-acetamido-1-(3-fluoro-5-were)-1-hydroxybutyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(4-acetamido-1-(2-fluoro-5-were)-1-hydroxybutyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(cyclopropylmethoxy)-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(4-m is Teal-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-were)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1,5-dimethoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(4-acetamido-1-(2,3-differenl)-1-hydroxybutyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(4-acetamido-1-(3,5-differenl)-1-hydroxybutyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)-3-(4-methylcyclohexyl)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-hydroxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(4-acetamido-1-(2,3-differenl)-1-hydroxybutyl)-N-(1-cyclopentyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((2-acetamidomethyl)(3-chloro-2-forfinal)methyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(2-amino-3-tert-butoxypropyl)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-(1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-hydroxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(1-cyclohexyl-1-hydroxy-3-(methylamino)p is opan-2-yl)-3-(1-(2,5-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(2-chloro-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-amino-1-cyclohexylmethyl-2-yl)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-cyclohexyl-3-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(2,3,4-tryptophanyl)pentyl)piperidine-1-carboxamide;
N-(1-(4,4-diverticulosis)-3-(methylamino)propan-2-yl)-3-(1-(2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(2,5-differenl)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
2-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)morpholine-4-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclopentyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)-3-(tetrahydro-2H-Piran-4-yl)propan-2-yl)piperidine-1-carboxamide;
3-(1-(benzo[b]thiophene-4-yl)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(benzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(1-cyclohexyl-3-(who ethylamino)propan-2-yl)-3-(1-(2-perbendaharaan-7-yl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
methyl-3-(1-(1-(1-cyclohexyl-3-(methylamino)propane-2-ylcarbonyl)piperidine-3-yl)-1-hydroxy-5-methoxyphenyl)benzoate;
2-(1-(benzo[b]thiophene-7-yl)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)morpholine-4-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-4-propionamido)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-(cyclopropylmethoxy)-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-4-(3-methylurea)butyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-amino-1-cyclohexylmethyl-2-yl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(4-acetamido-1-(3-chloro-2-forfinal)-1-hydroxybutyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(4-acetamido-1-(3-chloro-5-forfinal)-1-hydroxybutyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(4-acetamido-1-(2-chloro-3-forfinal)-1-hydroxybutyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1,5-dimethoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-hydroxy-4-methyl-1-(methylamino)pentane-2-yl)-3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-cycle is hexyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-hydroxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-chloro-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-acetamido-1-(3-chlorophenyl)-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)benzamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2,4-differenl)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-(1-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2-chloro-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(1-(4-forcelogix)-3-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(2,3,5-tryptophanyl)pentyl)piperidine-1-carboxamide;
2-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-forcelogix)-3-(methylamino)propan-2-yl)morpholine-4-carboxamide;
3-(1-(3-chlorophenyl)-4-(cyclopropanecarboxamide)-1-hydroxybutyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(4-butylamino-1-(3-chlorophenyl)-1-hydroxybutyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1(3-chlorophenyl)-4-(3,3-dimethylurea)-1-hydroxybutyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-bromophenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-cycloheptyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-4-(methylsulfonyl)butyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-4-(sulfanilamide)butyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(4-acetamido-1-(2,3-differenl)-1-hydroxybutyl)-N-(1-(4,4-diverticulosis)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-fluoro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-hydroxy-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
N-(1-cyclohexyl-3-(methylamino)propan-2-yl)-3-(1-(2,3-differenl)-5-methoxy-1-propylaminoethyl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-4-(2-methoxypropylamine)butyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-2-(2-methoxyethoxy)ethyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(1-cyclopentyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxamide;
2-(1-acetamido-1-(3-chloro-2-forfinal)-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)morpholine-4-carboxamide;
3-(-(2-bromo-5-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-fluoro-2-(o-tolyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(3-hydroxy-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-4-(2,2,2-triptoreline)butyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(1-cyclopentyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-(1-(3-fluoro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(3'-chloro-6-forbiden-2-yl)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclopentyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(1-(3,3-diversilobum)-3-(methylamino)propan-2-yl)-3-(1-(3-fluoro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-butylamino-1-(3-chloro-2-forfinal)-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
2-((3-chloro-2-forfinal)(3 methoxypropane)methyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)morpholine-4-carboxamide;
N-(2-amino-5-methoxy-4,4-dimethylpentyl)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-amino-5-methoxy-4,4-dimethylpentan-2-yl)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)butane-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-Fortini is)-1-hydroxy-5-methoxyphenyl)-N-(3-cyclohexyl-2-(methylamino)propyl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(1-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-amino-4-cyclohexylmethyl-2-yl)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-fluoro-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(benzo[b]thiophene-7-yl)-1-hydroxy-5-methoxyphenyl)-N-(1-(methylamino)-3-(tetrahydro-2H-Piran-4-yl)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2,3-dihydrobenzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-ethoxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-hydroxy-4-methylcyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-hydroxy-4-methylcyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-methoxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)butane-2-yl)piperidine-1-carboxamide;
N-(3-amino-4-cyclohexyl-1-hydroxybutane-2-yl)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-is illogical-1-hydroxy-3-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(2,3,5-tryptophanyl)pentyl)piperidine-1-carboxamide;
3-(1-(2-chloro-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-(1-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(1-(4-forcelogix)-3-(methylamino)propan-2-yl)-3-(1-hydroxy-5-methoxy-1-(2,3,5-tryptophanyl)pentyl)piperidine-1-carboxamide;
N-(2-amino-3-(4,4-diverticulosis)propyl)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(3-amino-1-(3-lordamantr)-N-hydroxypropan-2-yl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-hydroxy-4-methylcyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2,4-differenl)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2,4-differenl)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-amino-1-(3-lordamantr)-1-hydroxypropan-2-yl)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-((3-chlorophenyl)(2-hydroxyethoxy)methyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(2-amino-3-cyclopentylpropionyl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(2-amino-3-(tetrahydrofuran-2-yl)propyl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-amino-3-(then it is carbonated shall return-2-yl)propan-2-yl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-2-(2-methoxyethoxy)ethyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(2-amino-3-(tetrahydro-2H-Piran-4-yl)propyl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-amino-3-(tetrahydro-2H-Piran-2-yl)propan-2-yl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-amino-3-(3-methoxyisobutyl)propan-2-yl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(2-amino-3-(3-methoxycarbonyl)propyl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(2-amino-3-cyclohexylprop)-3-(1-(3-chloro-2-forfinal)-5-methoxyphenyl)piperidine-1-carboxamide;
N-(2-amino-3-(tetrahydrofuran-2-yl)propyl)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-amino-3-(tetrahydrofuran-2-yl)propan-2-yl)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(2-amino-4-phenylbutyl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(2-amino-4-cyclohexylmethyl)-3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(6-fluoro-3'-methylbiphenyl-2-yl)-1-hydroxy-5-methoxyphenyl)-N-(piperidine-3-yl)piperidine-1-carboxamide;
3-((3-chloro-2-forfinal)(3 methoxypropane)methyl)-N - (1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(1-amino-3-(tetrahydro-2H-Piran-2-yl)propan-2-yl)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(2-amino-3-(3-methoxycarbonyl)propyl)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
N-(1-amino-3-(3-methoxyisobutyl)propan-2-yl)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-((3-chlorophenyl)(2-propionyloxy)methyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(4-cyclohexylpiperidine-3-yl)-3-(1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1,6-dihydroxyethyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(1-cyclohexyl-3-(methylamino)propan-2-yl)-3-((2,3-differenl)(2 propionyloxy)methyl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-2-(2-methoxyacetate)ethyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(3-amino-1-cyclohexylmethyl-2-yl)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(4-cyclohexylpiperidine-3-yl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-methoxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(4-acetamido-1-(3-chloro-2-forfinal)-1-hydroxybutyl)-N-(3-amino-1-cyclohexylmethyl-2-yl)PIP is ridin-1-carboxamide;
3-((3-chloro-2-forfinal)(2 propionyloxy)methyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-methoxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(4-(pentane-3-yloxy)piperidine-3-yl)piperidine-1-carboxamide;
N-(3-amino-1-(4-forcelogix)-1-hydroxypropan-2-yl)-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-(1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(1-(3-lordamantr)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-acetamido-5-ethoxy-1-(3-forfinal)pentyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-(3,4-diverticulitis)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-(4-methoxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-(1-acetamido-1-(3-chlorophenyl)-5-ethoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-(2-amino-3-(3-lordamantr)-3-hydroxypropyl)1-3-(1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
and their enantiomers, diastereoisomers and pharmaceutically acceptable salts.

8. The connection according to claim 7, selected from the group including:
(3R)-N-((S)-1-amino-cyclohexylprop-2-yl)-3-((S)-1-hydroxy-1-fenilpentil) piperidine-1-carboxamide;
3-((S)-(3-methoxypropane)(phenyl)methyl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)benzamide;
(3R)-3-((R)-(2-cyclopropylmethoxy)(phenyl)methyl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
(3S)-N-((S)-1-amino-3-cyclohexylprop-2-yl)-3-((R)-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(phenyl)methyl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(phenyl)methyl)-N-((S)-2-amino-3-cyclohexylprop)piperidine-1-carboxamide;
(3R)-N-((S)-1-amino-3-cyclopentylpropionic-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
(2R)-2-((S)-(3-methoxypropane)(phenyl)methyl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)morpholine-4-carboxamide;
(3R)-N-((R)-3-tert-butoxy-1-aminopropan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-3-((S)-(3-methoxypropane)(phenyl)methyl)benzamide;
(3R)-N-((S)-1-amino-3-phenylpropane-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
(3R)-N-((S)-1-amino-3-cyclohexylprop-2-yl)-3-((S)-1-hydroxy-1-phenylheptane)piperidine-1-carboxamide;
(3S)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((R)-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
(3S)-N-((S)-1-amino-3-cyclohexylprop-2-yl)-3-(R)-5-ethoxy-1-fenilpentil)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(phenyl)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-ethoxypropane)(phenyl)methyl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-1-amino-3-cyclohexylprop-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(phenyl)methyl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)-N-methylpiperidin-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-4-methoxy-1-phenylbutyl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(4-forfinal)methyl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(2-forfinal)methyl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
(3S)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-cyclohexyl-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-4-cyclopropyl-1-hydroxy-1-phenylbutyl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(3-cyanophenyl)methyl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
(3S)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-5-ethoxy-1-fenilpentil)piperidine-1-carboxamide;
(3S)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((R)-5-ethoxy-1-fenilpentil)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-is hydroxy-5-methoxy-1-fenilpentil)cyclohexanecarboxylic;
(3R)-N-((2S)-1-amino-4-(trifluoromethyl)pentane-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(phenyl)methyl)-N-((S)-3-cyclohexyl-1-(ethylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-ethoxypropane)(phenyl)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-1-amino-3-cyclohexylprop-2-yl)-3-((S)-5-ethoxy-1-hydroxy-1-fenilpentil)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
(3R)-3-((S)-(3-ethoxypropane)(phenyl)methyl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)-3-methylpiperidin-1-carboxamide;
(3R)-N-((S)-2-amino-5-methoxy-4,4-dimethylpentyl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3S)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((R)-1-(3-forfinal)-5-methoxyphenyl)piperidine-1-carboxamide;
(R)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-3-((S)-1-fluoro-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(3-forfinal)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-1-amino-3-cyclohexylprop-2-yl)-3-((S)-1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((R)-1-cyclohexyl-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-labels is propoxy)(2,4-differenl)methyl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(3,4-differenl)methyl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(3-cyanophenyl)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(2-allylphenol)methyl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(phenyl)methyl)-N-((S)-3-cyclohexyl-1-(propylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-5-ethoxy-1-hydroxy-1-fenilpentil)piperidine-1-carboxamide;
(3R)-3-((R)-(3-propoxyphene)(phenyl)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-m-carpenter)piperidine-1-carboxamide;
(3R)-N-((S)-1-amino-5-methoxy-4,4-dimethylpentan-2-yl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(2S)-N2-(1-((R)-3-((R)-(3-methoxypropane)(phenyl)methyl)piperidine-1-yl)-2-nitrovinyl)-3-cyclohexylprop-1,2-diamine;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-2-amino-5-methoxy-4,4-dimethylpentyl)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-ka is backslid;
3-((S)-1-amino-3-cyclohexylprop-2-ylamino)-4-((R)-3-((R)-(2-cyclopropylmethoxy)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
(3R)-3-((S)-1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)-N-((S)-piperidine-3-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-4,4,4-Cryptor-1-hydroxy-1-m-tributyl)piperidine-1-carboxamide;
3-((S)-1-amino-3-cyclohexylprop-2-ylamino)-4-((R)-3-((R)-(3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-((S)-1-amino-3-cyclohexylprop-2-ylamino)-4-((R)-2-((S)-(3-methoxypropane)(phenyl)methyl)morpholino)cyclobuta-3-ene-1,2-dione;
methoxypropane)(phenyl)methyl)piperidine-1-yl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)-1,2,5-thiadiazole-3-amine;
(3R)-3-((R)-(3-methoxypropane)(phenyl)methyl)-N-((S)-1-(butylamino)-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(phenyl)methyl)-N-((S)-3-cyclohexyl-1-(isobutylamino)propan-2-yl)piperidine-1-carboxamide;
(R)-N-((S)-1-cyclohexyl-3-(dimethylamino)propan-2-yl)-3-((R)-5-ethoxy-1-hydroxy-1-fenilpentil)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-ethoxypropane)(3,4-differenl)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(2,5-differenl)-1-hydroxy-5-methoxyphenyl the l)piperidine-1-carboxamide;
(3R)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-fenilpentil)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(3,4-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-((S)-1-amino-3-cyclohexylprop-2-ylamino)-4-((R)-3-((S)-1-hydroxy-1-phenylheptane)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-((2S,3S)-3-amino-1-cyclohexylmethyl-2-ylamino)-4-((R)-3-((R)-(3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-((2S,3R)-3-amino-1-cyclohexylmethyl-2-ylamino)-4-((R)-3-((R)-(3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-((R)-3-((R)-(3-methoxypropane)(phenyl)methyl)piperidine-1-yl)-4-(N-((S)-1-amino-3-cyclohexylprop-2-yl)-N-methylamino)cyclobuta-3-ene-1,2-dione;
(3R)-3-((S)-1-(2-(p-tolyloxy)-5-were)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((S)-3-cyclohexyl-1-(methylamino)propane-2-ylamino)-4-((R)-3-((R)-(3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
(3R)-3-((R)-(3-methoxypropane)(2-(trifluoromethyl)phenyl)methyl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
3-((S)-1-amino-3-cyclohexylprop-2-ylamino)-4-((R)-3-((R)-(3-methoxypropane)(4-forfinal)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-((S)-1-amino-3-cyclohexylprop-2-ylamino)-4-((R)-3-((R)-(3-methoxypropane)(2-forfinal)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-the ion;
(3R)-3-((R)-(3-methoxypropane)(phenyl)methyl)-N-((S)-3-cyclohexyl-1-(isobutylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(phenyl)methyl)-N-((S)-3-cyclohexyl-1-(pentylamine)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-1-(3-isopropylphenyl)-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-4,4,4-Cryptor-1-hydroxybutyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(5-chloro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(R)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-3-((S)-5-cyclopropyl-1-hydroxy-1-fenilpentil)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(2-phenylphenyl)methyl)-N-((S)-2-amino-3-cyclohexylprop)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(2-(2-cyclopropylethyl)phenyl)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((S)-3-cyclohexyl-1-(ethylamino)propane-2-ylamino)-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
(3R)-3-((S)-1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-1-amino-5-methoxy-4,4-dimethylpentan-2-yl)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)disappear to the-2-yl)-3-((S)-1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-((S)-1-amino-3-cyclohexylprop-2-ylamino)-4-((R)-3-((R)-(3-methoxypropane)(2,4-differenl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-((S)-1-amino-3-cyclohexylprop-2-ylamino)-4-((R)-3-((R)-(3-methoxypropane)(3,4-differenl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
(3R)-N-((S)-1-(carbamoylmethyl)-3-cyclohexylprop-2-yl)-3-((S)-1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-((S)-3-cyclohexyl-1-(propylamino)propane-2-ylamino)-4-((R)-3-((R)-(3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(3-(trifluoromethyl)phenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
3-((S)-3-cyclohexyl-1-(isobutylamino)propane-2-ylamino)-4-((R)-3-((R)-(3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-((S)-3-(butylamino)-1-cyclohexylprop-2-ylamino)-4-((R)-3-((R)-(3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
(3R)-3-((S)-1-(2-(p-tolyloxy)-5-were)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(5-chloro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-((S)-3-cyclohexyl-1-(methylamino)propane-2-differenl)methyl)piperidine-1
Il)cyclobuta-3-ene-1,2-dione;
3-((S)-1-amino-3-cyclohexylprop-2-ylamino)-4-((R)-3-((R)-(3-methoxypropane)(2-(trifluoromethyl)the dryer is l)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxamide;
3-((S)-1-cyclohexyl-3-(pentylamine)propane-2-ylamino)-4-((R)-3-((R)-(3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
3-((S)-1-cyclohexyl-3-(isobutylamino)propane-2-ylamino)-4-((R)-3-((R)-(3-methoxypropane)(phenyl)methyl)piperidine-1-yl)cyclobuta-3-ene-1,2-dione;
(3R)-3-((S)-1-(2-(p-tolyloxy)-5-were)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(5-chloro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-(Penta-4-enyloxy)(phenyl)methyl)benzamide;
N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-5-methoxy-1-fenilpentil)benzamide;
3-((S)-(2-ethoxyethoxy)(phenyl)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)benzamide;
(3R)-3-((S)-1-(2-(cyclopropylmethoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-hydroxy-5-methoxy-1-m-carpenter)-N-((S)-4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3S)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((R)-5-methoxy-1-(thiophene-2-yl)pentyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1,1,1-Cryptor-2-hydroxy-6-meloxicam-2-yl)PIP is ridin-1-carboxamide;
3-((S)-(2-(acetylamino)ethoxy)(phenyl)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)benzamide;
(3R)-3-((S)-1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((R)-1-hydroxy-5-methoxy-1-fenilpentil)benzamide;
3-((S)-(3-ethoxypropane)(phenyl)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)benzamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(benzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(pyridine-2-yl)pentyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(2-cyclopropylmethoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(cyclopentyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(phenyl)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carbothioamide;
(3R)-N-((S)-1-amino-3-cyclohexylprop-2-yl)-3-((S)-1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-hydroxy-5-m is toxi-1-(2-(neopentylene)phenyl)pentyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(1-methyl-1H-imidazol-2-yl)pentyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(thiophene-2-yl)pentyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(thiophene-3-yl)pentyl)piperidine-1-carboxamide;
N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((R)-1-hydroxy-5-methoxy-1-m-carpenter)benzamide;
N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-o-carpenter)benzamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(thiazol-2-yl)pentyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(3-were)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(4-were)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(2-were)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(R)-3-((S)-1-(2-(o-tolyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(2-amino-ethyl)-N-methylpiperidin-1-ka is backslid;
N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)benzamide;
N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((R)-1-(4-forfinal)-1-hydroxy-5-methoxyphenyl)benzamide;
(3R)-3-((S)-1-hydroxy-5-methoxy-1-(quinoline-8-yl)pentyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(2-forfinal)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-fluoro-2-phenylphenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(3-forfinal)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(4-forfinal)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-hydroxy-5-methoxy-1-(2-methylbenzofuran-7-yl)pentyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-hydroxy-1-(2-isobutylbenzene-7-yl)-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((R)-1-hydroxy-5-methoxy-1-fenilpentil)-3-methylpiperidin-1-carboxamide;
(3R)-3-((S)-1-(2-(cyclopentyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3S)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((R)-1-(2-fluoro-5-were)-5-methoxyphenyl)Piperi the Jn-1-carboxamide;
(3R)-3-((S)-1-(benzo[b]thiophene-7-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-ethoxypropane)(3-forfinal)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-1-amino-3-cyclohexylprop-2-yl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-ethoxypropane)(3-chlorophenyl)methyl)-N-((S)-1-amino-3-cyclohexylprop-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1,5-dihydroxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(5-methylthiazole-2-yl)pentyl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(4-chloropyridin-2-yl)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(R)-3-((S)-1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)-N-(2-methyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(o-tolyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(m-tolyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(meth the laminitis)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-(3,3-diversilobum)-1-(methylamino)propan-2-yl)-3-((S)-1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(benzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)benzamide;
(3R)-3-((S)-1-(2-(4-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(5-fluoro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(3-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(2-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclopentyl-1-(methylamino)propan-2-yl)-3-((S)-1-(2,3-dihydrobenzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(2,5-dimetilfenil)pentyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(3-ethylphenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)is ropan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(2,3-dimetilfenil)pentyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(3, 5dimethylphenyl)pentyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(2-chlorophenyl)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(4-chlorophenyl)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(3-methoxyphenyl)pentyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(cyclopropylmethoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-4-cyclopropyl-1-hydroxybutyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(3-fluoro-5-were)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(2-fluoro-5-were)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(5-fluoro-2-were)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(2-fluoro-3-were)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((1R,2R)-1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-((S)-1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((1S,2R)-1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-((S)-1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-(1-hydroxycyclohexyl)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-(1-hydroxycyclohexyl)-2-(methylamino)propyl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-ethoxypropane)(3-chlorophenyl)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((1S)-1-(3-chlorophenyl)-1,5-dihydroxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(4-chloropyridin-2-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-ethoxypropane)(phenyl)methyl)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(3,5-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclopentyl-1-(methylamino)propan-2-yl)-3-((S)-5-ethoxy-1-(2,3-differenl)-1-hydroxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-phenylphenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-(tetrahydro-2H-Piran-4-yl)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(2R)-2-((R)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)morpholine-4-carboxamide;
(3R)-N-((1R,2R)-3-amino-1-cyclohexyl-1-hydroxypropan-2-yl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((1S,2R)-3-amino-1-cyclohexyl-1-hydroxypropan-2-yl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((1R,2R)-1-cyclopentyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((1S,2R)-1-cyclopentyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(o-tolyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(2-methyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(2-ethyleneoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-Carbo who said;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((R)-3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(5-chloro-1-methyl-1H-imidazol-2-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2,2-debtorrent[d][1,3]dioxol-4-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxyethyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(benzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-1-(1H-indazol-7-yl)-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(2,3-dichlorophenyl)methyl)-N-((S)-3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(4-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(2-methyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(3-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-(2-methyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-(o-tolyloxy)-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(o-tolyloxy)-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3)-3-((S)-1-(2-(5-fluoro-2-methylphenoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-
1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(4-fluoro-2-methylphenoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(2,3-dihydrobenzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-(3,3-diversilobum)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-(3,3-diversilobum)-1-(methylamino)propan-2-yl)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(cyclopentyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(2-cyclopropylmethoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(2-chlorophenoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-hydroxy-5-methoxy-1-(2-(neopentylene)phenyl)pentyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(3-(methylthio)phenyl)pentyl)piperidine-1-carboxamide;
(3R)-3-((S)-4-(acetylamino)-1-(3-chlorophenyl)-1-hydroxybutyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(allyloxy)-5-forfinal)-1-Ki-the Roxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(5-fluoro-2-methoxyphenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(2-fluoro-6-methoxyphenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-4-cyclopropyl-1-hydroxy-1-(2-phenoxyphenyl)butyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((2S)-5,5,5-Cryptor-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1,5-dimethoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(ethylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((1S)-1-(3-chlorophenyl)-1,5-dihydroxyethyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-4-cyclopropyl-1-(3-forfinal)-1-hydroxybutyl)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-m-carpenter)piperidine-1-carboxamide;
(3R)-3-((R)-(3-ethoxypropane)(m-tolyl)methyl)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-3-((S)-1-(2,3-differenl)-5-ethoxy-1-hydroxyphenyl)piperidine-1-carboxamide;
(3R-3-((S)-1-(2-fluoro-3-were)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-fluoro-3-were)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(CIS-4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclopropyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(3-were)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(4-were)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((1S,2R)-1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((1R,2R)-1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-(1-hydroxycyclohexyl)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-(1-hydroxycyclohexyl)-2-(methylamino)propyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carbothioamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(quinoline-8-yl)pentyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(p-tolyloxy)-5-were)-1-hydroxy-5-methoxyphenyl)-N-(2-methyl-1-(methyl) - Rev. Ino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-5-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-5-ethoxy-1-hydroxyphenyl)-N-((S)-3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-(TRANS-4-forcelogix)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-ethoxypropane)(3-forfinal)methyl)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(2,3,5-tryptophanyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclopentyl-1-(methylamino)propan-2-yl)-3-((S)-5-ethoxy-1-(2,3,5-tryptophanyl)-1-hydroxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(2-ethyleneoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((R)-3-hydroxy-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-fluoro-2-phenylphenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(2-forfinal)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(3-forfinal)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)Piperi the Jn-1-carboxamide;
(3R)-3-((S)-1-(2-(4-forfinal)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-5,5-debtor-1-hydroxyhexyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-methoxypropane)(2,3-dichlorophenyl)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2,3-dichlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-ethoxypropane)(2,3-dichlorophenyl)methyl)-N-((S)-3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(benzo[b]thiophene-7-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(benzo[b]thiophene-2-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-hydroxy-5-methoxy-1-(3-(triptoreline)phenyl)pentyl)-N-((S)-4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(5-perbendaharaan-7-yl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N'-cyano-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamidine;
(3R)-3-((S)-1-acetamido-1-(3-forfinal)-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carb is camid;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-(3,3-diversilobum)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(3-(trifluoromethyl)phenyl)-1-hydroxy-5-methoxyphenyl)benzamide;
(3R)-3-((S)-1-(2-(o-tolyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)-N-((S)-4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(benzyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(m-tolyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-5-ethoxy-1-hydroxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)-3-(TRANS-4-methylcyclohexyl)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(2-(trifluoromethyl)phenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-5-ethoxy-1-(2,3,5-tryptophanyl)-1-hydroxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-fluoro-3-were)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)the PCC is n-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2,3-dichlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-ethoxypropane)(2,3-dichlorophenyl)methyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2,3-dichlorophenyl)-5-ethoxy-1-hydroxyphenyl)-N-((S)-3-cyclopentyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(4-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)~1-(5-fluoro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(3-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(2-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-fluoro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-(4-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-ethoxypropane)(3-chlorophenyl)methyl)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamid is;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-(TRANS-4-forcelogix)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(2-chlorophenyl)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((1R)-1-(2'-chlorobiphenyl-2-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(4-chlorophenyl)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(3-chlorophenyl)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(2R)-2-((R)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)morpholine-1-carboxamide;
(3R)-3-((S)-1-acetamido-1-(3-chlorophenyl)-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(benzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-4,4,4-Cryptor-1-(methylamino)butane-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(2-(trifluoromethyl)phenoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)propane--yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(2,2-debtorrent[d][1,3]dioxol-4-yl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(o-tolyloxy)-3-were)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2,3-dichlorophenyl)-5-ethoxy-1-hydroxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(3-(triptoreline)phenyl)pentyl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(2-(triptoreline)phenyl)pentyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(p-tolyloxy)-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(o-tolyloxy)-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(5-fluoro-2-methylphenoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(4-fluoro-2-methylphenoxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(2-(cyclopentyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(2-cyclopropylmethoxy)phenyl)-1-hydroxy-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-5-ethoxy-1-(2,3-differenl)-1-hydroxyphenyl)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(4-pertenece)-5-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3,5-debtor-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-ethoxypropane)(3-chloro-2-forfinal)methyl)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-5-methoxy-1-(propionamide)pentyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)-3-((S)-1-(2,3,5-tryptophanyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-ethoxypropane)(2,3,5-tryptophanyl)methyl)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-(3,3-diversilobum)-1-(methylamino)propan-2-yl)-3-((R)-1-hydroxy-5-methoxy-1-(3-(triptoreline)phenyl)pentyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-hydroxypropoxy)-1-(3-chlorophenyl)-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylaminopropane-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(2-(pyridine-3-yloxy)phenyl)pentyl)piperidine-1-carboxamide;
(3R)-3-((R)-1-acetamido-1-(3-chloro-2-forfinal)-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-acetamido-1-(3-chloro-2-forfinal)-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(allyloxy)-3-bromophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-(isobutylamino)-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-5-ethoxy-1-(2,3,5-tryptophanyl)-1-hydroxyphenyl)-N-((S)-3-(4,4-diverticulosis)-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((2S)-5,5,5-Cryptor-4-methyl-1-(methylamino)pentane-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(benzyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-5-methoxy-1-(propionamide)pentyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(4-pertenece)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)-3-((S)-1-(5-fluoro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(2-(trifluoromethyl)phenoxy)phenyl)-1-hydroxy-5-ketoxime who yl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-(isobutylamino)-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-(isobutylamino)-5-methoxyphenyl)-N-((S)-3-cyclohexyl-1-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxypropyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(S)-N-((S)-N-cyclohexyl-3-(methylamino)propan-2-yl)-2-((R)-5-methoxy-1-fenilpentil)morpholine-4-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxybutyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((R)-1-cyclohexyl-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)benzamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxyphenyl)-N-((S)-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-1-cyclohexyl-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1,4-dihydroxybutyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((2R,3S)-3-hydroxy-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(benzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-tert-butylbenzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(metiram the but)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((2S,3S)-3-amino-1-cyclohexylmethyl-2-yl)-3-((S)-1-(2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((1S,2R)-1-cyclopentyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-((S)-1-(3-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-2-amino-3-cyclohexylprop)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methoxy-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-cyanophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-chloro-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((5)-4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((2R,3S)-3-hydroxy-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(benzo[b]thiophene-4-yl)-1-hydroxy-5-methoxyphenyl)-N-((5)-4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-4-acetamido-1-(2-forfinal)-1-hydroxybutyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-3-((S)-1-(3-fluoro-2-were)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-(S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-3-((R)-1-(3-fluoro-2-were)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-3-((S)-1-(3-fluoro-4-were)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-3-((R)-1-(3-fluoro-4-were)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-3-((S)-1-(3-fluoro-2-hydroxyphenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((1S,2R)-1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-((S)-1-(2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((2S,3R)-3-amino-1-cyclohexylmethyl-2-yl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-2-(methylamino)propyl)piperidine-1-carboxamide;
(3R)-N-((S)-1-(CIS-4-forcelogix)-3-(methylamino)propan-2-yl)-3-((S)-1-(2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-1-(TRANS-4-forcelogix)-3-(methylamino)propan-2-yl)-3-((S)-1-(2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-1-(TRANS-4-forcelogix)-3-(methylamino)propan-2-yl)-3-((R)-1-(2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((1S,2R)-1-cyclopentyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-chloro-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclopentyl--(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-2-amino-3-cyclohexylprop)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(benzofuran-4-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-4-acetamido-1-(3, 5dimethylphenyl)-1-hydroxybutyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-1-cyclohexyl-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(4,4-diverticulosis)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-2-amino-3-cyclohexylprop)-3-((S)-1-(benzo[b]thiophene-4-yl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methoxy-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-cyano-5-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-carbamoylphenoxy)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-2-amino-3-cyclohexylprop)-2-((R)-1-(benzo[b]thiophene-7-yl)-1-hydroxy-5-methoxyphenyl)morpholine-4-carboxamide;
(3R)-3-((S)-4-acetamido-1-(3-fluoro-5-were)-1-hydroxybutyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-4-acetamido-1-(2-fluoro-5-were)-1-hydroxybutyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-Carbo who said;
(3R)-3-((S)-1-(2-(cyclopropylmethoxy)-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-were)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-1-(3-chloro-2-were)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1,5-dimethoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-4-acetamido-1-(2,3-differenl)-1-hydroxybutyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-4-acetamido-1-(3,5-differenl)-1-hydroxybutyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)-3-(4-methylcyclohexyl)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(CIS-4-hydroxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-hydroxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-4-acetamido-1-(2,3-differenl)-1-hydroxybutyl)-N-((1S,2R)-1-cyclopentyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-(2-acetamidomethyl)(3-chloro-2-forfinal)methyl)-N-((S)-1-CEC is hexil-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(2-acetamidomethyl)(3-chloro-2-forfinal)methyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((R)-2-amino-3-tert-butoxypropyl)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((1S,2R)-1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-
carboxamide;
(3R)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(CIS-4-hydroxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-hydroxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((1S,2R)-1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-((S)-1-(2,5-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-chloro-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((2S,3R)-3-amino-1-cyclohexylmethyl-2-yl)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(2,3,4-tryptophanyl)pentyl)piperidine-1-carboxamide;
(3R)-N-((S)-1-(4,4-diverticulosis)-3-(methylamino)propan-2-yl)-3-((S)-1-(2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2,5-differenl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(the IP-4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2,5-differenl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(R)-2-((R)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)morpholine-4-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((1S,2R)-1-cyclopentyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)-3-(tetrahydro-2H-Piran-4-yl)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((R)-1-(methylamino)-3-(tetrahydro-2H-Piran-4-yl)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(benzo[b]thiophene-4-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(benzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(CIS-4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-3-((S)-1-(2-perbendaharaan-7-yl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
methyl 3-((S)-1-((R)-1((S)-1-cyclohexyl-3-(methylamino)propane-2-ylcarbonyl)piperidine-3-yl)-1-hydroxy-5-methoxyphenyl)benzoate;
(3R)-2-((R)-1-(benzo[b]thiophene-7-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)morpholine-4-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-4-propionamido)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-(cyclopropylmethoxy)-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-
((S)-4,4-dimethyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-4-(3-methylurea)butyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((2S,3S)-3-amino-1-cyclohexylmethyl-2-yl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-4-acetamido-1-(3-chloro-2-forfinal)-1-hydroxybutyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-4-acetamido-1-(3-chloro-5-forfinal)-1-hydroxybutyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-4-acetamido-1-(2-chloro-3-forfinal)-1-hydroxybutyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1,5-dimethoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((2R,3S)-3-hydroxy-4-methyl-1-(methylamino)pentane-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((1S,2R)-1-cyclohexyl-1-hydroxy-3-(METI is amino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(CIS-4-hydroxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-hydroxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-chloro-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((1S,2R)-1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
3-((S)-1-acetamido-1-(3~chlorophenyl)-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)benzamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(S)-1-(TRANS-4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(CIS-4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2,4-differenl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-1-(3-chloro-2,4-differenl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(1-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-chloro-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-1-(2-chloro-3-fluoro who enyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-1-(CIS-4-forcelogix)-3-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(2,3,5-tryptophanyl)pentyl)piperidine-1-carboxamide;
(3R)-2-((R)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-forcelogix)-3-(methylamino)propan-2-yl)morpholine-4-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-4-(cyclopropanecarboxamide)-1-hydroxybutyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-4-butylamino-1-(3-chlorophenyl)-1-hydroxybutyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-4-(3,3-dimethylurea)-1-hydroxybutyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-bromophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((1S,2R)-1-cycloheptyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-4-(methylsulfonyl)butyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-4-(sulfanilamide)butyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-4-acetamido-1-(2,3-differenl)-1-hydroxybutyl)-N-((S)-1-(4,4-diverticulosis)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-fluoro-2-phenoxyphenyl)-1-HYDR the xylose-5-methoxyphenyl)-N-((2R,3S)-3-hydroxy-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-3-((S)-1-(2,3-differenl)-5-methoxy-1-propionamide)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-4-((R)-2-methoxypropane)butyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-4-((S)-2-methoxypropane)butyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-2-(2-methoxyethoxy)ethyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((1S,2R)-1-cyclopentyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxamide;
2-((R)-1-acetamido-1-(3-chloro-2-forfinal)-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)morpholine-4-carboxamide;
(3R)-3-((S)-1-(2-bromo-5-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-fluoro-2-(o-tolyloxy)phenyl)-1-hydroxy-5-methoxyphenyl)-N-((2R,3S)-3-hydroxy-4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-4-(2,2,2-triptoreline)butyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((1S,2R)-1-cyclopentyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-((S)-1-(3-fluoro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3'-chloro-6-forbiden the l-2-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-cyclopentyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-1-(3,3-diversilobum)-3-(methylamino)propan-2-yl)-3-((S)-1-(3-fluoro-2-phenoxyphenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-bpyramid-1-(3-chloro-2-forfinal)-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(S)-3-((R)-1-(3-chloro-2-forfinal)-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-2-((S)-(3-chloro-2-forfinal)(3 methoxypropane)methyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)morpholine-4-carboxamide;
(3R)-N-((S)-2-amino-5-methoxy-4,4-dimethylpentyl)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-1-amino-5-methoxy-4,4-dimethylpentan-2-yl)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((2S,3R)-1-cyclohexyl-3-(methylamino)butane-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-3-cyclohexyl-2-(methylamino)propyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-(S)-1-(1-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((R)-1-(1-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((2R,3S)-3-amino-4-cyclohexylmethyl-2-yl)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-CT is the oksamid;
(3R)-N-((2S,3S)-3-amino-4-cyclohexylmethyl-2-yl)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-fluoro-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(benzo[b]thiophene-7-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(methylamino)-3-(tetrahydro-2H-Piran-4-yl)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2,3-dihydrobenzofuran-7-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-ethoxy-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-hydroxy-4-methylcyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-hydroxy-4-methylcyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-methoxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)butane-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-(1-cyclohexyl-3-(methylamino)butane-2-yl)piperidine-1-carboxamide;
(3R)-N-((2S,3S)-3-amino-4-cyclohexyl-hydroxybutane-2-yl)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((1S,2R)-1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(2,3,5-tryptophanyl)pentyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2-chloro-3-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(1-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-1-(TRANS-4-forcelogix)-3-(methylamino)propan-2-yl)-3-((S)-1-hydroxy-5-methoxy-1-(2,3,5-tryptophanyl)pentyl)piperidine-1-carboxamide;
(3R)-N-((S)-2-amino-3-(4,4-diverticulosis)propyl)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((1S,2R)-3-amino-1-(3-lordamantr)-1-hydroxypropan-2-yl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-hydroxy-4-methylcyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2,4-differenl)-1-hydroxy-5-methoxyphenyl)-N-((1S,2R)-1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2,4-differenl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-forcelogix)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((1S,2R)-(3-amino-1-(3-lordamantr)-1-hydroxy)propane-2-yl)-3-((S)-1-(2-fluoro-3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-chlorophenyl)(2-hydroxyethoxy)methyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(R)-N-((S)-2-amino-3-cyclopentylpropionyl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((2S)-2-amino-3-(tetrahydrofuran-2-yl)propyl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((2S)-1-amino-3-(tetrahydrofuran-2-yl)propan-2-yl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3S)-3-((R)-1-(3-chlorophenyl)-2-(2-methoxyethoxy)ethyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((S)-2-amino-3-(tetrahydro-2H-Piran-4-yl)propyl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((2S)-1-amino-3-(tetrahydro-2H-Piran-2-yl)propan-2-yl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-1-amino-3-(3-methoxyisobutyl)propan-2-yl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-2-amino-3-(TRANS-3-methoxyisobutyl)propyl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-2-amino-3-(CIS-3-methoxycarbonyl)propyl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(S)-3-((S)-2-amino-3-cyclohexylprop)-3-((R)-1-(3-chloro-2-forfinal)-5-methoxyphenyl)piperidine-1-carboxamide;
(S)-3-((S)-2-amino-3-cyclohexylprop)-3-((S)-1-(3-chloro-2-forfinal)-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((2S)-2-amino-3-(tetrahydrofuran-2-yl)propyl)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((2S)-1-amino-3-(tetrahydrofuran-2-yl)propane-2-the l)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-2-amino-4-phenylbutyl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-2-amino-4-cyclohexylmethyl)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(S)-3-((R)-1-(3-chloro-2-forfinal)-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(S)-3-((S)-1-(3-chloro-2-forfinal)-5-methoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(6-fluoro-3'-methylbiphenyl-2-yl)-1-hydroxy-5-methoxyphenyl)-N-((S)-piperidine-3-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-chloro-2-forfinal)(3 methoxypropane)methyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((2S)-1-amino-3-(tetrahydro-2H-Piran-2-yl)propan-2-yl)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-2-amino-3-(3-methoxycarbonyl)propyl)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-N-((S)-1-amino-3-(3-methoxyisobutyl)propan-2-yl)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-chlorophenyl)(2-propionyloxy)methyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((3S,4S)-4-cyclohexylpiperidine-3-yl)~3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((1S)-1-(3-chlorophenyl)-1,6-dihydroxyethyl)-N-((S)-1-cyclohexyl-3-(m is thylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((2S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-3-((R)-(2,3-differenl)(2 propionamides)methyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-2-(2-methoxyacetate)ethyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((2S,3S)-3-amino-1-cyclohexylmethyl-2-yl)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((3S,4S)-4-cyclohexylpiperidine-3-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(CIS-4-methoxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-methoxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-4-acetamido-1-(3-chloro-2-forfinal)-1-hydroxybutyl)-N-((2S,3R)-3-amino-1-cyclohexylmethyl-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-4-acetamido-1-(3-chloro-2-forfinal)-1-hydroxybutyl)-N-((2S,3R)-3-amino-1-cyclohexylmethyl-2-yl)piperidine-1-carboxamide;
(3R)-3-((R)-(3-chloro-2-forfinal)(2 propionamides)methyl)-N-((2S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(2,3-differenl)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(CIS-4-methoxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((3R,4R)-4-(pentane-3-yloxy)piperid the n-3-yl)piperidine-1-carboxamide;
(3R)-N-((1S,2R)-3-amino-1-(TRANS-4-forcelogix)-1-hydroxypropan-2-yl)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxyphenyl)-N-((2S)-1-(3-lordamantr)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-acetamido-5-ethoxy-1-(3-forfinal)pentyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-((1R,3R,4S)-3,4-diverticulitis)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(CIS-4-methoxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)-N-((S)-1-(TRANS-4-methoxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-3-((S)-1-acetamido-1-(3-chlorophenyl)-5-ethoxyphenyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide;
(3R)-N-((2R,3S)-2-amino-3-(3-lordamantr)-3-hydroxypropyl)-3-((S)-1-(3-chloro-2-forfinal)-1-hydroxy-5-methoxyphenyl)piperidine-1-carboxamide;
and their pharmaceutically acceptable salts.

9. The compound which is 3-(1-hydroxy-5-methoxy-1-(2-(pyridine-3-yloxy)phenyl)pentyl)-N-(4-methyl-1-(methylamino)pentane-2-yl)piperidine-1-carboxamide or its enantiomers, diastereoisomers, and pharmaceutically acceptable salts.

10. Pharm is Titicaca composition, having the properties of a renin inhibitor containing an effective amount of a compound according to any one of claims 1 to 9, or its pharmaceutically acceptable salt, and a pharmaceutically acceptable carrier.



 

Same patents:

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula or pharmaceutically acceptable salt thereof, synthesis methods thereof, pharmaceutical compositions containing said compounds, and use thereof to prepare a medicinal agent having mTOR kinase and/or PI3K kinase inhibiting action.

EFFECT: improved properties of the derivatives.

15 cl, 72 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of general formula where: R1 denotes COORa1, CONRa2Ra2', CONRa4ORa4', where: each of Ra1 and Ra4 denotes a hydrogen atom; each of Ra2 and Ra2' denotes a hydrogen atom; Ra4' denotes a lower alkyl; or R1 denotes a heterocyclic group selected from the following groups, where Y2 denotes a hydrogen atom or a lower alkyl: R2 denotes O, S, SO, SO2; R3 denotes a phenyl which is substituted with 2 substitutes selected from halogen, CF3; X2 denotes CH or N; W denotes the following residue: where: W1 denotes CH or S; W2 denotes CH; W3 denotes C or N; and at least one of W1, W2 and W3 denotes a carbon atom; or pharmaceutically acceptable salt or ester thereof. The invention also relates to a pharmaceutical composition having Avrora A selective inhibitory action, which, along with a pharmaceutically acceptable carrier or diluent, contains at least one compound of formula I a an active ingredient.

EFFECT: aminopyridine or aminopyrazine derivatives which inhibit growth of tumour cells based on Avrora A kinase selective inhibitory action.

11 cl, 3 tbl, 24 ex

FIELD: chemistry.

SUBSTANCE: invention relates to novel organic compounds of formula where R1 denotes H; halogen; -C0-C7-alkyl-O-R3; -NR4R5; R2 denotes phenyl, substituted with one or two substitutes selected from a group consisting of C1-7alkyl, halogen-C1-7alkyl, C1-7alkoxy, halogen-C1-7alkoxy, phenoxy, halogen, C1-7alkylpiperazinyl-C1-7alkyl, C3-C8-cyclalkyl, C1-7alkylpiperidinyl-C1-7alkyl and C1-7alkylimidazolyl; R3 denotes H or phenyl-lower alkyl; R4 and R5 are independently selected from a group consisting of H; lower alkyl; lower alkoxy-carbonyl and amino; A, B and X are independently selected from C(R7) or N, provided that not more than one or A, B and X denotes N; R7 denotes H; R8 denotes hydrogen; n equals 0; Y denotes O; Z denotes C; W is absent; K denotes N or C, and either a) if K denotes C, the bond shown by a wavy line () is a double bond, Q is selected from O-N, S-N, O-CH and S-CH, where in each case, the left-hand O or S atom is bonded through a bond shown in formula I to K, the right-hand N or carbon (CH) atom is bonded to C through a bond shown by a dotted line () in formula I, provided that said bond, which is shown by the dotted line, is a double bond with C; and the bond shown by a thick line () is a single bond; or b) if K denotes N, the bond shown by a wavy line () is a single bond; Q denotes N=CH, where the left-hand N atom is bonded through a bond shown in formula I to K, the right-hand carbon (CH) atom is bonded to C through a bond shown by a dotted line () in formula I, provided that said bond, which is shown by a dotted line, is a single bond with C; and the bond shown by thick line () is a double bond; or salt thereof (preferably pharmaceutically acceptable salt). The invention also relates to a pharmaceutical composition, having inhibiting action on protein kinase, containing a compound of formula I or salt thereof in an effective amount and at least one pharmaceutically acceptable carrier material.

EFFECT: heterocyclic carboxamides as kinase inhibitors.

12 cl, 25 ex

FIELD: chemistry.

SUBSTANCE: present invention relates to a compound of formula I or a pharmaceutically acceptable salt thereof, where R1 denotes C1-C8-alkylaminocarbonyl, which is optionally substituted with a 5- or 6-member heterocyclic ring containing 3-4 ring heteroatoms selected from a group consisting of oxygen, nitrogen and sulphur, where the ring can be optionally substituted with C1-C8-alkyl or C1-C8-alkoxy group ; R2 denotes C1-C3-alkyl or a halogen; one of R3 and R4 denotes R6, and the other denotes R7; R5 denotes hydrogen or halogen; R6 denotes hydrogen, hydroxy group amino group, -SO2R8, -SO2NH2, -SO2NR9R10, -COR8, -CONHR8, -NHSO2R8, nitrile, carboxy, -OR8 or C1-C8-halogenalkyl; R7 denotes hydrogen, OR11, halogen, carboxy, -SO2R8, cyanogroup or C1-C8-halogenalkyl, or when R4 denotes R7, then R7 can also denote -NR12 R13 ; R8 R11 independently denote C1-C8-alkyl or C3-C8-cycloalkyl, which can be optionally substituted with hydroxy group, C1-C8-alkoxy group, nitrile, amino group, C1-C8-alkylamino group or di-C1-C8-alkyl)amino group; any R9 denotes C1-C8-alkyl or C3-C8-cycloalkyl, which can optionally be substituted with hydroxy group, C1-C8-alkoxy group, nitrile, amino group, C1-C8-alkylamino group, di(C1-C8-alkyl)amino group or a 5- or 6-member heterocyclic ring containing one or two ring heteroatoms selected from a group consisting of oxygen and nitrogen, where the ring can optionally be substituted with C1-C8-alkyl, and R10 denotes hydrogen or C1-C8-alkyl; or R9 and R10 together with a nitrogen atom with which they are bonded form a 5- or 6-member heterocyclic ring which can contain one or two additional nitrogen heteroatoms, where the ring can be optionally substituted with C1-C8-alkyl; any R12 denotes C1-C8-alkyl or C3-C8-cycloalkyl which can be optionally substituted with di(C1-C8-alkyl)aminogroup, and R13 denotes hydrogen or C1-C8-alkyl; or R12 and R13 together with a nitrogen atom with which they are bonded form a 5- or 6-member heterocyclic ring which contains one or two additional nitrogen heteroatoms, where the ring can optionally be substituted with C1-C8-alkyl.

EFFECT: possibility of using the compounds to produce a pharmaceutical agent for treating diseases mediated by phosphatidylinositol-3 kinase.

6 cl, 3 tbl, 181 ex

FIELD: chemistry.

SUBSTANCE: invention relates to hydroximoyl-tetrazole derivatives of formula (I), , where T is a tetrazole substitute, A is a phenyl or heterocycle, L1 and L2 are different linker groups, and Q is a carbocycle, use thereof as fungicide active agents, particularly in form of fungicide compositions, and methods of controlling phytopathogenic fungi, especially plants, using said compounds or compositions.

EFFECT: more effective use of the compounds.

13 cl, 2 tbl, 2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to novel diarylamine-containing compounds of formula (I) or formula (4b), pharmaceutically acceptable salts thereof, which have c-kit inhibiting properties. In formulae (I) and (4b), each R1 independently denotes H, -C(O)OH and -L1-C1-6alkyl, where L1 denotes -O- or -C(O)O-, or any two neighbouring R1 groups can together form a 5-6-member heterocyclic ring containing a nitrogen atom or an oxygen atom as a heteroatom, a 6-member heterocyclic ring with one or two nitrogen atom s as heteroatoms, optionally substituted with a C1-4alkyl, and R5 denotes hydrogen or C1-C6alkyl; values of radicals Ar and Q are given in the claim. The invention also relates to a pharmaceutical composition containing said compounds, and a method of treating diseases whose development is promoted by c-kit receptor activity.

EFFECT: more effective use of the compounds.

17 cl, 3 tbl, 9 ex

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of general formula where R denotes a thiazolyl group of formula R2 and R3 are selected from: hydrogen, C1-C3linear alkyl; R4 is selected from: C1-C3linear or C3cyclic alkyl, phenyl and thiophenyl; Z denotes a group of formula: -(L)n-R1; R1 is selected from: i) C1-C3linear or branched alkyl, optionally substituted with C1-C4alkoxycarbonyl, halogen; ii) substituted phenyl or substituted with one or two substitutes selected from halogen, methoxy- or hydroxy group, C1-C4alkoxycarbonyl; iii) dioxopiperazinyl and 2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl, substituted with C1-C3alkyl; or iv) heteroaryl rings containing 5-10 atoms selected from thiazole, triazole, 1H-imidazole, thiadiazole, oxazole, isoxazole, oxadiazole, benzodioxole, benzo(1,4)dioxepanyl, pyridine, pyrimidine, 1H-indole, 2,3-dihydrobenzo[b][1,4]dioxynil, which can be substituted with oine or two substitutes selected from: a) hydroxy; b) C1-C3alkyl (which can be substituted with one more two substitutes selected from: ) phenyl; ii) C1-C4alkoxycarbonyl; iii) naphthalenyl; iv) 2-methylthiazolyl) ; c) NHC(O)C1-C3alkyl; d) C1-C4alkoxycarbonyl; e) 1 -(tert-butoxycarbonyl)-2-phenylethyl; f) methoxybenzyl; g) phenyl which can be substuted with C1-C4alkoxy, halogen, methoxycarbonyl or >NHC(O)CH3; h) (methoxy-2-oxoethyl)carbamoyl; L denotes a group selected from: i) C(O)NH[C(R5aR5b)]w-; ii) -C(O)[C(R6aR6b)]x-; iii) -C(O)[C(R7aR7b)]yC(O)-; iv) -SO2[C(R8aR8b)]z-; R5a, R5b, R6a, R6b, R7a, R7b, R8a and R8b, each independently denotes: i) hydrogen; ii) C1-C3 linear alkyl which can be substituted with 1 or 2 halogen atoms; iii) phenyl which can be substituted with 1-2 substitutes selected from halogen and lower alkoxy; iv) heteroaryl rings selected from imidazolyl, imidazolyl substituted with methyl, benzo(1,4)oxazinyl, oxadiazolyl substituted with methyl; index n equals 0 or 1; indices w, x, y and z are each independently equal to a number from 1 to 3. The invention also relates to pharmaceutically acceptable salts of compounds of formula (I) and use of compounds of formula (I) to prepare a medicinal agent for treating protein tyrosine phosphatase beta-mediated conditions.

EFFECT: obtaining compounds of formula (I) as human protein tyrosine phosphatase beta (HPTP-β) inhibitors.

15 cl, 17 dwg, 13 tbl, 16 ex

FIELD: chemistry.

SUBSTANCE: invention relates to an isoxazoline-substituted benzamide derivative of formula or salt thereof, where A1 denotes a carbon or nitrogen atom, A2 and A3 independently denote a carbon atom, G denotes a benzene ring, W denotes an oxygen or sulphur atom, X denotes a halogen atom or C1-C6alkyl, arbitrarily substituted with a radical R4, Y denotes a halogen atom, cyano, nitro, C1-C6alkyl, C1-C6alkyl arbitrarily substituted with radical R4, -OR5, -N(R7)R6, phenyl, D-41, when n equals 2, each Y can be identical or different from each other, R1 denotes -C(R1b)=NOR1a, M-5, -C(O)OR1c, -C(O)SR1c, -C(S)OR1c, -C(S)SR1c, -C(O)N(R1e)R1d, -C(S)N(R1e)R1d, -C(R1d)=NN(R1e)R1lf, phenyl, phehnyl substituted with (Z)p1, or D-3, D-8, D-13-D-15, D-21, D-35, D-52-D-55 or D-57-D-59, R2 denotes C1-C6alkyl, -CH2R14a, E-5, C3-C6alkynyl, -C(O)R15, -C(O)OR15, -C(O)C(O)OR15 or -SR15, where, when R1 denotes -C(R1b)=NOR1a, M-5, or -C(R1b)=NN(R1e)R1f, R2 can denote a hydrogen atom, when R1 denotes -C(O)OR1c, -C(O)SR1c, -C(S)OR1c or -C(S)SR1c, R2 can denote hydrogen, when R denotes -C(O)N(R1e)R1d or -C(S)N(R1c)R1d, R2 can denote a hydrogen atom, when R1 denotes phenyl, phenyl substituted with (Z)p1, or D-3, D-8, -D-13-D-15, D-21, D-35, D-52-D-55 or D-57-D-59 R2 can denote C1-C6halogenalkyl, C1-C6alkyl arbitrarily substituted with a radical R14a, C3-C6alkenyl, -C(O)NH2, -C(O)N(R16)R15, or R2 together with R1 can form =C(R2b)R2a, R3 denotes C1-C6alkyl arbitrarily substituted with radical R4, D-1, D-3, D-8, D-13-D-15, D-21, D-35, D-41, D-52-D-55, D-57-D-59 denote aromatic heterocyclic rings, m equals an integer from 2 to 3, n equals an integer from 0 to 2.

EFFECT: isoxazoline-substituted benzamide derivative and salt thereof are used in pest control, against harmful arthropods in agriculture and horticulture or in livestock farming and in the field of hygiene.

12 cl, 18 tbl, 73 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 1,7-bis[4(5)-methyl-1,3-thiazol-2-yl]-3,5-dithia-1,7-diazaheptanes of general formula (1), which can be used in organic synthesis to produce macro-heterocyclic rings, as well as sorbents and extraction agents for precious and rare-earth metals. The method is realised by reacting hydrogen sulphide-saturated aqueous formaldehyde solution (37%) with 2-amino-4(5)-methylthiazole with molar ratio of initial reagents 2-amino-4(5)-methylthiazole: formaldehyde: hydrogen sulphide equal to 20:30:20, at temperature -5-5°C and atmospheric pressure for 8-12 hours.

EFFECT: improved method.

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of general formula

, where R is a group selected from: i) hydrogen; ii) phenyl and iii) thiophenyl; Z is a substituted or unsubstituted [1,3,4]thiadiazol-2-yl group, R1 is selected from: i) hydrogen; ii) straight C1-C6alkyl; iii) C6 or C10 aryl; iv) C(O)OR5; and v) 2-methylthiazol-4-yl; R5 denotes a straight or branched C1-C6alkyl; and index x equals 0 or 1. The invention also relates to use of compounds of formula (I) to prepare a medicinal agent having human protein tyrosine phosphatase beta (HPTP-β) inhibiting action and use in treatment.

EFFECT: compounds can be used as human protein tyrosine phosphatase beta inhibitors.

11 cl, 1 dwg, 1 tbl, 1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (1) (lb) in which A denotes a benzene ring; Ar denotes naphthalenyl which optionally contains 1-3 substitutes independently selected from a group comprising C1-C6alkyl, C3-C7cycloalkyl, C3-C7cycloalkyl-C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, hydroxy group, C1-C6alkoxy group, halogen, heteroalkyl, heteroalkoxy group, nitro group, cyano group, amino- and mono- or di- C1-C6alkyl-substuted amino group; R1 denotes hydrogen, halogen, C1-C6alkyl, C1-C6alkoxy group, carboxy group, heteroalkyl, hydroxy group optionally substituted with heterocyclylcarbonyl-C1-C6alkyl or R1 denotes N(R')(R")-C1-C6alkyl or N(R')(R")-carbonyl- C1-C6alkyl-, in which R' and R" are independently selected from a group comprising hydrogen, C1-C6alkyl, C3-C7cycloalkyl, C3-C7cycloalkyl-C1-C6alkyl, heteroalkyl, phenyl-C1-C6alkyl; or R1 denotes R'-CO-N(R")-C1-C6alkyl, R'-O-CO-N(R")- C1-C6alkyl- or R'-SO2-N(R")- C1-C6alkyl-, in which R' and R" are independently selected from a group comprising hydrogen, C1-C6alkyl, C3-C7cyclalkyl, C3-C7cycloalkyl- C1-C6alkyl or optionally substituted phenyl; R2, R2' and R2" independently denote hydrogen, halogen, cyano group, C1-C6alkyl, halogenated C1-C6alkyl or C1-C6alkoxy group; n equals 1; and pharmaceutically acceptable salts thereof. The invention also relates to use of compounds in any of claims 1-9, as well as to a pharmaceutical composition.

EFFECT: obtaining novel biologically active compounds with chymase inhibiting activity.

14 cl, 128 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing α,ω-bis-[2-(N,N-dimethylamino)thien-5-yl]alkanes, which involves reaction of α,ω-bis-[2-(N,N-dimethylaminomethyl)ethynyl]alkane, where (alkane = propyl, butyl, hexyl), with excess elementary sulphur (S8) in the presence of a three-component catalyst consisting of cobalt acetylacetonate Co(acac)2, triphenylphosphine Ph3P and triethylaluminium Et3Al, taken in molar ratio α,ω-bis-[2-(N,N-dimethylaminomethyl)ethynyl]alkane:S8:Co(acac)2:Ph3P:Et3Al=10:(40-60):(0.3-0.7):(0.6-1.4):(0.9-2.1), preferably 10:50:0.5:1.0:1.5, at temperature 125-135°C and atmospheric pressure for 5-7 hours.

EFFECT: obtaining novel compounds which can be used as biologically active compounds, additives to oil and process lubricants and in fine organic synthesis.

1 cl, 1 tbl, 1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to novel imidazoline derivatives of formula (I), where n equals 0 or 1, R1 denotes a saturated branched or straight unsubstituted C1-C4alkyl, saturated unsubstituted C3-C8cycloalkyl or unsubstituted phenyl bonded through a C1-C3alkyl chain, R2 denotes an unsubstituted or halogen atom-monosubstituted phenyl or thiophenyl, or unsubstituted phenyl bonded through a C1-C3alkyl chain, R3 denotes a saturated branched or straight C1-C8alkyl which is not substituted or contains one substitute selected from a group comprising -COO-methyl, thiomethyl or thiobenzyl, or a phenyl which is mono-substituted with a halogen atom and bonded through a C1-C3alkyl chain, R4 denotes a C1-C4alkyl, R5 and R6 independently denote a saturated branched or straight C1-C6alkyl, in form of a racemate, enantiomers, diastereomers, mixture of enantiomers or diastereomers or a separate enantiomer or diastereomer, bases and/or salts with physiologically compatible acids. The invention also relates to a method for synthesis of the compound of formula (I), intermediate compounds of formula B , a medicinal agent based on the compound of formula (I) or formula B and use of compounds of formula (I) or formula B to prepare a medicinal agent.

EFFECT: novel derivatives of imidazoline and substituted aldehyde of formula B, having µ-opiate receptor affinity, are obtained.

16 cl, 2 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of general structural formula:

or to pharmaceutically acceptable salts, where Z denotes -O- or -CH2- or -CH2-CH2-; X1 denotes a covalent bond or -O-; Y1 denotes a covalent bond or C1-C10 alkylene, provided that Y1 is a covalent bond only when X1 denotes a covalent bond; R1 denotes a) (C3-C7)cycloalkyl or b) phenyl or heteroaryl, which is a monovalent heteroatomatic monocyclic radical ring containing 1-2 heteroatoms, independently selected from nitrogen and sulphur, possibly substituted with 1-3 groups, independently selected from fluorine, chlorine, bromine, (C1-C6)alkyl or (C1-C6)-alkoxy; R2 denotes -OC(O)(NH2), -OC(O)(NHR9), -NHC(O)OR9, -C(O)R9, -C(O)(NH2), -C(O)(NHR9) or -NHC(O)H, where R9 denotes a linear or branched C1-C5 alkyl or a linear or branched (C1-C5)alkoxyalkyl; R3 denotes H, C1-C5 alkyl, -NHC(O)R10 or OH, where R10 denotes C1-C3 alkyl, provided that when R3 denotes -OH, X1 is not O and R2-Y1-X1 is not -OC(O)(NH2), -OC(O)(NHR9), -NHC(O)OR9 or -NHC(O)H; -Q denotes

, where N and N are bonded by bonds denoted by a wavy line; R4 denotes H; R5 and R6 independently denote: a) H, (C1-C10)alkyl, (C4-C10)cycloalkylalkyl, hydroxylated (C4-C10)cycloalkylalkyl, halo(C4-C10)cycloalkylalkyl, (C1-C2)alkyl(C4-C10)cycloakylalkyl, (C4-C10)bicycloalkyl(C1-C3)alkyl, (C1-C5)alkoxy(C1-C5)alkyl; or a saturated heterocyclyl(C1-C3)alkyl, where the saturated heterocyclic ring is selected from 5-, 6- or 7-member heterocyclic rings which contain 1 heteroatom independently selected from N and O; or b) phenyl(C1-C2)alkyl, phenoxymethyl, each of which is possibly with 1-3 groups independently selected from fluorine, chlorine, (C1-C3)alkyl, (C1-C3)alkoxy; provided that both R5 and R6 are not H; G denotes NH2 or NHR7; R7 denotes (C1-C6)alkyl; or R5 and R7 together denote -CH2, -(CH2)2 or -(CH2)3, possibly substituted with 1-2 groups independently selected from (C1-C8)-alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C2)alkyl or (C1-C8)alkoxy. The invention also relates to compounds selected from the group, pharmaceutical compositions, a method for antagonising one or more aspartate proteases, as well as methods of treating aspartate protease-mediated disorders.

EFFECT: obtaining novel biologically active compounds having activity towards rennin.

35 cl, 33 ex, 4 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: there are described compounds of 3-cyanonaphthalene-1-carboxylic acid and perhydroxyalkylmethylpiperazine of formula

, where R1 means C1-C4alkyl, R2 and R3 mean halogen, R4 is selected from the group consisting of 2-furanyl, 3-furanyl, 2-thiophen, 3-thiophen, phenyl, benzyl, 2-benzofuranyl, etc., R5 is selected from the group consisting of hydrogen and R6, R6 means a subgroup of general formula

which are antagonists of tachykinin receptors. Also, there are described pharmaceutical compositions containing such compounds, and methods for making such compounds and intermediate products for making the compounds according to said methods.

EFFECT: preparation of new compounds.

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) or pharmaceutically acceptable salts thereof, where Q is CH or N; R2 is C1-C4 alkyl or C3-C4-cycloalkyl; Y is R5-O; where R5 is propynyl; X is selected from a group consisting of aryl, heteroaryl, C1-C5-alkyloxy, heterocycloalkyl, arylamino, heteroarylamino, heteroaryl-C1-C4-alkylamino, aryloxy, aryl-C1-C2-alkyloxy or C3-C6-cycloalkyl-C1-C4-alkyloxy, each of which is optionally substituted with 1-3 times; the optional substitute(s) for X is(are) independently selected from a group comprising halogen, cyano, trifluoromethyl, nitro, hydroxy, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkyloxy-C1-C4-alkoxy, -SMe, SO2-C1-C2-alkyl, -NMe2, - C(O)O-C1-C5-alkyl, -SCF3, -SO2-NH2, -SO2-C2-alkyl-OH, -CONH2, -COMe, - CONH-C1-C4-alkyl, -CONMe2, -NHCOMe, -CH2COOEt, -OCH2COOEt, -CH2- cyclopropyl, and each R3 and R4 is H; where aryl denotes phenyl or naphthyl; heteroaryl denotes monocyclic or bicyclic hydrocarbon containing 5-10 ring atoms, one or more of which are heteroatoms selected from O, N or S; heterocyclyl denotes piperidinyl or benzodioxolyl; or a compound or pharmaceutically acceptable salt thereof, selected from a group comprising (4-dimethylaminophenyl)-[4-(4-cyclopropylphenyl)-6-propargyloxyquinazolin-2-yl]methanone, (3-sulphamoylphenyl)amide 4-(4-isopropylphenyl)-6-prop-2-ynyloxy-3,4-dihydroquinazoline-2-carboxylic acid, [3-(2-hydroxyethanesulphonyl)phenyl]amide 4-(4-isopropylphenyl)-6-prop-2-ynyloxy-3,4-dihydroquinazoline-2-carboxylic acid, (3-methylsulphanylphenyl)amide 4-(4-isopropylphenyl)-6-prop-2-ynyloxy-3,4-dihydroquinazoline-2-carboxylic acid, (3-methanesulphonylphenyl)amide 4-(4-isopropylphenyl)-6-prop-2-ynyloxy-3,4-dihydroquinazoline-2-carboxylic acid, and (5-ethanesulphonyl-2-hydroxyphenyl)amide 4-(4-isopropylphenyl)-6-prop-2-ynyloxy-3,4- dihydroquinazoline -2-carboxylic acid. The invention also relates to a pharmaceutical composition based on the compound of formula (I) and use of the compound of formula (I).

EFFECT: novel benzoquinazoline derivatives, which are useful in treating bone disorders, are obtained.

6 cl, 128 ex

FIELD: chemistry.

SUBSTANCE: present invention describes novel compounds of formula (I), where substitutes R1, R2, R3, Ar and A are described in the formula of invention, having histone deacetylase inhibiting activity, use thereof and methods for synthesis of said compounds.

EFFECT: improved composition properties.

15 cl, 72 ex, 9 tbl, 6 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to compound of formula I: where: R1 represents R6C(O)-, R6SO2-, (R6)2NC(O)-; R2 represents hydrogen, -CF3 or R8; R3 represents -T-R9; R4 represents -COOH or -COOR8; R5 represents -CH2F or -CH2O-2, 3, 5, 6 - tetrafluorophenyl; R6 represents R6a or R6b; two R6 groups, together with the atom to which they are bound optionally form 3-10-member aromatic or non-aromatic ring; and where each R6 is independently substituted with 6 substituents, independently selected from R; R6a and R6b each independently represents (C1-C3)-aliphatic group, (C6-C10)-aryl-, (C6-C10)-aryl-(C1-C12) aliphatic group; R represents halogen, -OR7, -R7; each R7 is independently selected from: hydrogen, (C1-C12)-aliphatic group, (C6-C10)-aryl; R8 represents (C1-C12)-aliphatic group; T represents direct bond or (C1-C6)-aliphatic group, where to 2 aliphatic carbon atoms in T can be optionally substituted with O; R9 is optionally substituted (C6-C10)-aryl or (C5-C10) - heteroaryl, invention also relates to pharmaceutical composition, to methods of treatment, inhibition of caspase-mediated processes, to method of cell preservation with application of formula I compounds application of such compositions for treatment of caspase-mediated diseases and to methods of obtaining formula I compounds.

EFFECT: obtained and described are novel compounds, which can be useful in treatment of caspase-mediated diseases.

38 cl, 22 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new compounds of formula (I) , where Z means where R means hydrogen, C4-C6cycloalkyl group attached either through one of ring carbon atoms, or through a lower alkylene group attached to the ring, or a linearly chained or branched lower alkyl group or a lower hydroxyalkyl group, or a lower aminoalkyl group, or a phenyl(lower alkyl) group optionally substituted with 1-2 substitutes chosen from lower alkyl, lower alkoxy, halogen and hydroxy, or heteroaryl(lower alkyl)group where heteroaryl is chosen from the group consisting from thienyl, substituted with lower alkyl group, imidazolyl, and thiazolyl substituted with the lower alkyl group; n means 0 or 1; or Z means a group where R means the lower alkyl group; X1 means methylene or NH group; and X2 means methylene; or X1 means methylene and X2 means methylene or a bond; or X1 means methylene, and X2 means O, S or a bond; Y1 means methylene, and Y2 means methylene, vinylene, ethylene, or a bond; Ar1 means unsubstituted or substituted phenyl; Ar2 means unsubstituted or substituted phenyl, unsubstituted or substituted thienyl, unsubstituted or substituted furyl, unsubstituted or substituted pyridyl; and when Ar1 and Ar2 are substituted, each Ar1 and Ar2 are independently substituted with one or more substituted chosen from lower alkyl, lower alkoxy, hydroxy, lower hydroxyalkyl, halogen, di- and trihaloalkyl, di- and trihaloalkoxy, mono- and dialkylamino, alkilthio, alkyl ester and nitro; provided that Ar1 and Ar2 do not simultaneously mean unsubstituted phenyl; W means oxygen or sulphur; or to their pharmaceutically acceptable salts; provided those specified in cl. 1 of the patent claim. Besides the invention concerns the compounds chosen from the group, to compounds of formula (I), to pharmaceutical compositions, to a method of inhibition of monoamine receptor activity, to a method of inhibition of monoamine receptor activation, to a method of treating a diseased state associated with serotonin receptor, to a method of treating schizophrenia, to a method of treating migraine, and also to a method of treating psychosis.

EFFECT: preparation of the new biologically active compounds capable to inhibit monoamine receptor activity.

65 cl, 140 ex, 5 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to a novel compound N-(1-{(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl) piperidin-4-yl]propyl}piperidin-4-yl)-N-ethyl-2-[4- (methylsufonyl)phenyl]acetamide or its pharmaceutically acceptable salts. The invention also relates to a method for synthesis of the compound in paragraph 1, as well as to a pharmaceutical composition.

EFFECT: obtaining a novel biologically active compound with activity towards CCR5 (chemokine receptor 5).

6 cl, 6 ex, 2 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to new compounds of formula I or their pharmaceutically acceptable salts exhibiting the properties of voltage-dependent sodium channel inhibitors, such as NaV1.8. The latter play a central role in generating the action potentials in all excitable cells such as neurons and myocytes, and can be used for treating such diseases as epilepsy, irritable bowel syndrome, chronic pain, etc. In the compounds of formula I: R1 and R2 together with nitrogen atom a substituted ring selected from: (A),(B),(C),(D) or (E), which are specified in the patent claim, where in the ring (A): each of m1 and n1 is independently equal to 0-3, provided m1+n1 is equal to 3-4; z1 is equal to 0-4; Sp1 represents -O-, -S-, -NR'- or C1-C4alkylidene linker in which one methylene ring is optionally or independently substituted by -O-, provided Sp1 is bound with carbonyl group through an atom different from carbon; the ring B1 represents a 5-6-members saturated or aromatic, monocyclic or heterocyclic ring containing 1-4 heteroatoms selected from O or N with the ring B1 is optionally substituted by w1 independent variants -R11 with w1 being equal to 0-1; where in the ring (B): G2 represents CH; each of m2 and n2 is independently equal to 0-3, provided m2+n2 is equal to 2-4; p2 is equal to 0-2; q2 is equal to 0 or 1; z2 is equal to 0-4; Sp2 represents a bond or C1-C6alkylidene linker in which up to two methylene links are optionally or independently substituted by -O-. The other radical values are specified in the patent claim.

EFFECT: making new compounds of formula I or to their pharmaceutically acceptable salts showing the properties of voltage-dependent sodium channel inhibitors.

67 cl, 4 tbl, 503 ex

Up!