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Mglur5 modulators. RU patent 2439068.

FIELD: medicine, pharmaceutics.

SUBSTANCE: described are novel compounds of general formula I:

(where values R¹-R⁵, X and Z are defined in invention description), pharmaceutical composition, which contains them, and application of claimed compounds as MGLUR5 modulators for inhibition of transient relaxations of lower esophageal sphincter or for treatment or prevention of gastroesophageal reflux disease.

EFFECT: obtaining compounds for treatment or prevention of gastroesophageal reflux disease.

14 cl, 87 ex

IPC classes for russian patent Mglur5 modulators. RU patent 2439068. (RU 2439068):

C07D413/14 - containing three or more hetero rings

C07D401/14 - containing three or more hetero rings

A61P25/22 - Anxiolytics

A61P23 - Anaesthetics

A61K31/42 - Oxazoles

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