Food additive containing long-chain polyunsaturated fatty acids (versions)

FIELD: food industry.

SUBSTANCE: present invention relates to a food additive to be administered to children. Alternatively, the food additive contains a protein source, a source of vitamins and minerals, a carbohydrates source as well as a lipids source including a source of docosahexaenoic acid, linoleic and linolenic acids. The ratio of ω-6:ω-3 fatty acids in the said food additive is 6:1 or less. Alternatively, the food additive contains protein, carbohydrate and lipid components; the lipid component includes 10% - 50% of canola oil, 5% - 40% of soybean oil, 5% - 40% of high-oleic sunflower oil, 5% - 40% of middle chain triglyceride oil, 1% - 20% of corn oil and 0.1% - 10% of a docosahexaenoic acid source.

EFFECT: food additive having a ratio of ω-6:ω-3 of fatty acids 6:1 and less improves the immune system functions, the heart-vascular system activity, bone tissue quality and has a favourable effect on mental processes.

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The technical field

The present invention relates to a food additive, to substitute a meal or snack, which is a source of nutrients for subjects suffering from chronic diseases, injuries, or delays in development, and contains a unique lipid mixture containing a certain level of DHA and lower ratio of ω-6:ω-3 fatty acids, similar to that present in the Western diet, and these additives have a positive impact on health and/or can be used to prevent serious consequences of the disease.

The level of technology

It is well known that infants, toddlers, and later of age in developed countries are the most picky about food. These food habits and improper selection of food parents cause children do not get enough nutrients necessary for adequate growth and development. Examples of such nutrients are ω-3 polyunsaturated fatty acid with long chain (LCPUFA). Long Chain Polyunsaturated Fatty Acid) and docosahexaenoic acid (DHA). Docosahexaenoic Acid).

It has been shown that DHA is necessary for cognitive development and forming of view, its accumulation in the brain occurs most intensively in the first two years of life. Currently there is not about what aktov, containing a complete set of nutrients, enriched with DHA and is intended for children ages 1 year to 12 years. This is due mainly to the lack of information regarding the benefits which provides a diet that includes ω-3 LCPUFA in children after cessation of breastfeeding.

However, in recent scientific surveys in the United States reported the use of a diet enriched with DHA in the amount of 30 mg per day or less, in children aged 1 to 12 years. If you extrapolate recommendations that exist for infants and adults, at a specified age group, it can be assumed that the use of DHA in the number 70-179 mg per day is desirable to provide a favourable impact on health, including the optimal development and functioning of the brain and cardiovascular system in different age groups.

These data suggest that interval up to 150 mg / day corresponds to the typical level of consumption of DHA young children and is considered the optimal level of enrichment. In addition, taking into account the specific benefits of an effective amount can be up to 500 mg per day for certain age groups. This is the most important to consider if the recommended concentration of DHA for infants and adults are designed to optimize time the development and functioning of the brain and cardiovascular system. However, currently on the shelves of grocery stores products containing specified a specific interval of concentrations of DHA and is intended for children aged 1 to 12 years, are missing.

The product is well-balanced in nutrients and contain an appropriate level of DHA in combination with a suitable mixture of dietary oils can solve other problems related to the harmonious growth and development. One such problem is the increase in the concentration of ω-6 fatty acids relative to ω-3 fatty acids in the diet.

Currently, the ratio of ω-6:ω-3 fatty acids in the Western diet is more than 5:1. It was shown that this change in the consumption of fatty acids which is excess intake of ω-6 polyunsaturated fatty acids (PUFAs) and a very high ratio of ω-6:ω-3, plays a role in the pathogenesis of various diseases, including diseases of the cardiovascular system, cancer, inflammatory and autoimmune diseases. It has been proven that children who receive insufficient amount of ω-3 fatty acids, there are a number of behavioural problems and health problems, including causeless anger, sleep problems and with learning, which proves the necessity of receiving adequate amounts of ω-3 fatty the slot.

To date, a lot of evidence that the low ratio of ω-6:ω-3 fatty acids has a beneficial effect on the immune system, cardiovascular system, bone and mental health. In particular, the results of many clinical studies show that the ω-6:ω-3 ratio less than 6:1 has a beneficial effect, while a ratio of 10:1 or more is associated with adverse health effects. Various Federal agencies and research centers emphasize on the need to increase the content of ω-3 fatty acids in the diet.

Currently available balanced nutritional foods for children are used as food supplements, meal replacements, snacks, as well as for the treatment of chronic diseases, damage, injury or delay development. These products generally is a composition designed to provide adequate nutrition, good taste, so patients were eaten with great pleasure. For example, a mixture of Enfamil® Kindercal® (Mead Johnson, Evansville, IN) intended for children aged 1 to 10 years and are used as dietary supplements, meal replacements and snacks, if children need additional foods, or as a full-fledged food when x is onionskin diseases, damages, injuries or disabilities. In the composition Kindercal® the ratio of ω-6:ω-3 is approximately 5:1, but the mixture does not contain DHA. The mixture Pediasure® (Ross Products Division, Abbott Laboratories, Columbus, OH) is designed for children aged 1 to 10 years with elevated dietary needs or for children with low power due to chronic illness or poor appetite. Similarly, the mixture of Pediasure® does not contain DHA. However, the ratio of ω-6:ω-3 fatty acid in this mixture is about 10.8:1.

Because these foods are designed to enrich the diet of children, picky about food, or for additional support pediatric patients with chronic diseases, there are many opportunities to improve the composition of these products by optimizing its lipid composition by introducing proven effective amount of DHA in combination with a mixture of oils, providing the ratio of ω-6:ω-3 fatty acids, optimal for the harmonious development of the brain and the functioning of the cardiovascular system.

The existing problems associated with deficiency of adequate dietary products on the market, have been partially solved by the above-described mixtures. However, these mixtures do not allow to solve the health problems associated with insufficient intake CPUFAs, because they have a high ratio of ω-6:ω-3 fatty acids.

For example, in the application WO 2003043445, Carey et al., reveals the infant formula intended for the enrichment of the diet of children with preliminary materials for the synthesis of arachidonic acid and DHA, as well as a mixture of linoleic and alpha-linolenic acids. Because the mixture contains only predecessors LCPUFAs, it does not include DHA. Described mixture also has a relatively high ratio of ω-6:ω-3 fatty acids of approximately from 7:1 to 12:1.

In the application WO 200215719, Fuchs et al., disclosed composition dietary supplements intended for immunocompromised patients, containing a source of lipids, providing about 18% of the total caloric value of the product. The ratio of ω-6:ω-3 fatty acids in the specified source of lipid is from about 1:1 to 10:1. However, the composition does not contain DHA.

In applications for U.S. patent number 20030000391 and 20030185941, Highman et al., describes organic food product containing at least one acid or eykozapentaenovuyu (EPA), or DHA. Specified product also contains such useful acids as arachidonic acid, and linolenic acid (ω-6 fatty acid). However, in these applications is not disclosed that the food product has a specific ratio of ω-6:ω-3 fatty acids.

<> In the patent application WO 2001047377, Myhre, describes the nutritional lipid composition containing a mixture of oils in the aqueous phase to improve the freshness of the product. Specified nutritional lipid mixture also has a high ratio of ω-6:ω-3 fatty acids.

In U.S. patent number 5,902,797, Bell et al., disclosed is a dietary Supplement containing carbohydrates, proteins and fats necessary for people with reduced appetite. DHA is not part of the specified supplements.

Thus, from the above it is obvious that at the present time there is a need for the creation of superior nutritional supplements containing protein, carbohydrates and a source of lipids that include a significant amount of DHA and having a low ratio of ω-6:ω-3 fatty acids. Similarly, it is desirable to create a food composition, which will have a positive impact on children's health and/or to help prevent the serious consequences of the disease. Finally, it is particularly desirable to obtain a nutrient composition that meets the specific nutritional needs of children suffering from chronic diseases, injuries, injury, or lack of development.

The invention

Briefly, the present invention relates to a new nutritional composition comprising a protein component, a carbohydrate component and a lipid component that includes Ni is sustained fashion source of DHA, the ratio of ω-6:ω-3 fatty acids in the specified nutrient composition is about 6:1 or less.

According to another aspect of the present invention relates to a method of feeding entity, which is specified in the introduction to the subject of nutritional supplements containing protein component, a carbohydrate component and a lipid component that includes an additional source of DHA, the ratio of ω-6:ω-3 fatty acids in the specified nutrient composition is about 6:1 or less.

According to some variants of implementation of the present invention is a food additive contains a complete nutritional composition. For example, a dietary Supplement may be the only source of calories for the subject and can be used together with animal milk, human milk and/or any other milk, suitable for children in the first months, and then together with solid food or drinks.

The lipid mixture is declared in accordance with the present invention, has an improved ratio of ω-6:ω-3 fatty acids compared with the traditional food additives and existing full-nutrient compositions. For example, describe a food additive, as claimed in accordance with the present invention, contains a unique lipid mixture, including the source of the oil,rich in DHA, canola oil, high class sunflower oil, corn oil and oil containing medium chain triglycerides (MCT), which ultimately provides a sufficient amount of DHA and low ratio of ω-6:ω-3 fatty acids, compared to the typical Western diet, and has a beneficial effect on health and contributes to the prevention of serious consequences of various diseases.

Thus, the present invention relates to improved dietary Supplement that contains a protein source, a source of carbohydrates and a source of lipids, including sufficient DHA and low correlation with the ratio of ω-6 fatty acids to ω-3 fatty acids. In addition, the present invention relates to a food additive, which has a beneficial effect on health and/or contributes to the prevention of serious consequences of diseases in children. Finally, the present invention relates to methods and compositions to meet the specific nutritional needs of children suffering from chronic illnesses, damages, injuries or disorders of growth.

Description of the preferred embodiments of the invention

Following is a detailed description of the preferred embodiments of the present invention, which is illustrated by one or bore alkemi examples. Each of these examples are presented to explain the embodiments of the present invention and in any case does not limit its essence. In fact, any person skilled in the art it is obvious that can be made various changes and modifications of the claimed invention within the following claims. In particular, the properties and characteristics of one possible implementation of the present invention can be used to describe or illustrate another variant implementation of the present invention. Therefore, it is understood that the present invention includes its variants and modifications that fall within the following claims. Other objects, characteristic features and aspects of the present invention are further addressed, or are apparent from the below detailed description. Any person skilled in the art it is obvious that the present discussion is merely a description of an example of embodiments of the present invention without limiting the breadth of his essence.

In accordance with the present invention it was shown that a dietary Supplement for children, balanced in nutrients, ready-to-use form can be obtained by combining the b is lcov, lipids and carbohydrates in a single composition in proportions suitable for children. For example, according to one variant, the present invention relates to a food additive that contains a protein source, a source of carbohydrates and a source of lipids, which, in turn, includes a source of DHA, the ratio of ω-6:ω-3 fatty acids in the specified nutrient composition is about 6:1 or less.

According to some variants of implementation of the present invention is a food additive is completely balanced nutritional Supplement for use in pediatric practice. Used herein, the terms "children" and "pediatric" is used in relation to a person whose age ranges from 9 months to thirteen years, and, according to some variants of implementation of the present invention, for children aged from one year to twelve years. According to some variants of implementation of the present invention the age of the children ranges from one to ten years.

Used herein, the term "balanced nutrient" refers to a food additive that can be used as a complete source of nutrients and provides that the intake of almost all daily allowance of vitamins, minerals and/or microlam now in combination with proteins, carbohydrates and fats.

The present invention has several advantages compared to conventional food additives, as stated dietary Supplement contains a mixture of lipids and necessary amount of DHA, and has a ratio of ω-6:ω-3 fatty acids of about 6:1 or less. For example, the ratio of ω-6:ω-3 fatty acids in such traditional food additive, as PediaSure®, is approximately 11:1. It is believed that eating foods with a lower ratio of ω-6:ω-3 fatty acids may have a beneficial effect on health, including, without limitation specified, improving immune system function, improve cardiovascular system, prevention or treatment of bronchial asthma attacks and other respiratory diseases, improving the quality of bone tissue and a beneficial effect on mental processes.

Without attachment to any theory it is believed that the present invention has the advantage over conventional nutritional supplements because of its favorable effect due to the influence of the concentration of phosphatidylserine (PS). Phosphatidylserine) inside the cells. PS is a phospholipid, which is required for normal functioning of all cells in the body, but the greatest concentrations it is present in the cells of the heads is on the brain. It was shown that PS has a positive impact on the processes of thinking and memory. It is believed that DHA modulates the levels of PS as in vivo, and in vivo, as it has been experimentally shown that the PS levels directly correlate with the content of DHA in neuronal cells. Akbar, Mohammed, et al., Docosahexaenoic Acid: A Positive Modulator of Akt Signaling in Neuronal Survival, PNAS 102(31):10858-10863 (August, 2007). It has been determined that changes in the proportions of the phospholipids is not easy to stimulate, modulate the concentration of PS due to DHA is a unique mechanism.

Trace amounts of PS can be found in lecithin. According to some variants of implementation of the present invention, a dietary Supplement containing lecithin and DHA. Such a combination of DHA, probably increases the intracellular concentration of PS. Thus, the present invention is particularly useful for improving brain function, memory, verbal abilities, mood, sociability, combat stress and impaired attention and/or hyperactivity in children.

Profile of nutrients in addition declared in accordance with the present invention, can be designed according to one variant of implementation of the present invention, especially for children who do not get enough nutrients from traditional sources. For example, the requested pisew what I additive may be used in pediatric patients in children choosy in food, as a substitute for food (for example, a balanced nutrient) or snacks, as well as to meet the specific nutritional needs of children suffering from chronic diseases, damage, injury or delay development. Similarly, a food additive, as claimed in accordance with the present invention, can be used as food additives in children recovering from illness, reabilitiruyut after surgical interventions, as well as children with reduced appetite, anorexia, or bulimia in children with impaired uptake of other nutrient sources.

The food additive may further include vitamins and minerals in quantities sufficient to meet the daily needs of children aged from one to thirteen years, and, according to some variants of implementation of the present invention, these nutrients are installed according to the FDA (Food and Drug Administration). A food additive may also contain other ingredients such as antioxidants, emulsifiers, stabilizers, preservatives, dietary fibers, colorants, flavors and sweeteners, as well as other biologically active additives.

According to one variant of its implementation of the present invention also apply the method to the power of the subject, which is the introduction to the specified subject of nutritional supplements containing protein component, a carbohydrate component and a lipid component that includes an additional source of DHA, the ratio of ω-6:ω-3 fatty acids in the specified nutrient composition is about 6:1 or less. According to a particular variant of implementation of the present invention the subject is a child.

Range of suitable carbohydrates, proteins and lipids can vary widely and is well known to experts in the field related to the production of food supplements for children. The selection of one or more of the ingredients described in the text, depends on the composition of dietary supplements and also on the preference of the manufacturer and the final consumer. In order feasibility of some of the ingredients that are suitable for use in accordance with the present invention, described in detail below. However, the present invention is in no way limited to any of these specific ingredients, any person skilled in the art it is obvious that in addition to the ingredients described in the text, can be used with other suitable ingredients.

One of the components of the claimed food compositions are carbohydrates. Used herein, the term "carbohydrate" or "carbohydrate" refers to a simple carbohydrate is m (i.e. monosaccharides and disaccharides), and complex carbohydrates (i.e. polysaccharides).

Dietary Supplement that is claimed in accordance with the present invention may contain any source of carbohydrates, which can be natural, synthetic or obtained by genetic modification of organisms, this method of obtaining studied now, or is at the stage of development. For example, examples of sources of carbohydrates that can be used in accordance with the present invention are, without limitation specified, corn syrup, maltodextrin, sugar, such as glucose, fructose, dextrose, lactose, galactose sugars, sucrose and maltose; sugar alcohols such as sorbitol, mannitol or xylitol; syrups such as maltitol, corn syrup, rice syrup and corn syrup high-fructose; and also mixtures thereof.

Commercial sources of carbohydrates, presented above, are readily available and well known to specialists in this field. For example, corn syrup is manufactured by Cerestar USA, Hammond, Ind. Rice syrup and syrup on the basis of glucose produced by the company California Natural Products in Lathrop, Calif. Various corn syrups and corn syrup with high fructose produced by Cargil company in Minneapolis, Minn. Fructose is supplied by the company ..Staley in Decatur, III.

In addition to carbohydrates, is written above, the claimed nutritional Supplement also contains synthetic sweeteners, such as Sucralose, saccharin, cyclamate, aspartame, aspartame, Acesulfame K and/or sorbitol. The use of these synthetic sweeteners preferably, if a food additive is intended for overweight people or people suffering from diabetes type II, and prone to hyperglycemia. Dietary Supplement that is claimed in accordance with the present invention, includes any source of synthetic sweeteners, which can be natural, synthetic or obtained by genetic modification of organisms, this method of obtaining studied now, or is at the stage of development.

Another component of the nutrient composition, as claimed in accordance with the present invention are proteins. Used herein, the term "protein" or "proteins" refers to organic compounds, which include amino acids, linked by peptide bonds.

Dietary Supplement that is claimed in accordance with the present invention includes any protein source, which can be natural, synthetic or obtained by genetic modification of organisms specified source well studied. For example, examples of sources of carbohydrates that can be used in accordance with this the current invention, are, without limitation specified, milk protein concentrate, milk proteins, whey protein, whey protein concentrate, dried whey, lactalbumin, egg protein (such as albumin), soy protein, soy protein isolate, rice protein, beef collagen, pea proteins, potato proteins, casein, Caseinate (e.g., sodium Caseinate, sodium Caseinate-calcium, calcium Caseinate, potassium Caseinate), animal proteins (e.g. proteins, beef or fish), as well as mixtures thereof.

To proteins, which are suitable for use in accordance with the methods and compositions claimed in accordance with the present invention, also includes hydrolyzed proteins. Used herein, the term "hydrolyzed protein" or "protein hydrolysates" refers to proteins that have been processed in a special way for the destruction of one or more peptide (amide) bond. These protein fragments and free amino acids are more easily digested. The destruction of amide bonds can be carried out simultaneously at the production stage, for example, by heating or splitting.

Suitable sources of protein hydrolysates include, without limitation specified, hydrolyzed soy protein, hydrolyzed casein, hydrolyzed whey protein, hydrolyzed rice protein, hydrolyzed egg albumin, hydrolyzed relativesource, the combination of hydrolysates of animal and plant proteins, and mixtures thereof.

According to some variants of implementation of the present invention the protein may be in the form of free amino acids. Free amino acids can be introduced into the food additive in addition to the protein component. Examples of suitable amino acids include, without limitation specified, histidine, isoleucine, leucine, lysine, methionine, cysteine, phenylalanine, tyrosine, threonine, tryptophan, valine, alanine, arginine, asparagine, aspartic acid, glutamic acid, glutamine, glycine, Proline, serine, carnitine, taurine, and mixtures thereof. According to another variant implementation of the present invention as a protein Supplement may include small peptides containing amino acids. These small peptides containing amino acids, can be both natural and synthetic.

According to some aspects of the present invention the protein component includes a concentrate of milk proteins, which is a mixture of casein and whey protein. According to some variants of implementation of the present invention the protein component is a mixture of casein and whey protein, the ratio of casein : whey protein in this mixture is about 8:2.

The other is they are part of the food additives, declared in accordance with the present invention are lipids. Used herein, the term "lipid" or "lipids" refers to the fat or oil organic components. The term "lipid" includes all compounds based on fatty acids. Lipids are classified as follows: saturated, polyunsaturated and monounsaturated.

Sources of lipids suitable for use in the compositions claimed in accordance with the present invention are, without limitation specified, coconut oil, fish oil (e.g., fat, herring or sardines), walnut oil (for example, hazelnut oil, walnut oil, Brazil nut oil, chestnut oil, peanut oil), butter, pumpkin seeds, rice bran oil, sesame oil, soybean oil, corn oil, sunflower oil, evening primrose oil biennial, rapeseed oil, olive oil, linseed oil, cottonseed oil, high class, safflower oil, palm stearin, soy lecithin, oil of Australian walnut, MCT oil (medium-chain triglyceride)oil, sunflower oil, high class sunflower oil, palm oil, palm olein, olein seeds, palm, canola oil, milk fat (for example, fats, milk, butter), wheat germ oil, butter, whole grains, and mixtures thereof.

According to some variants of the implementation of this breath is retene lipid component is a mixture of several lipids of various types. For example, a dietary Supplement can contain a mixture of at least one source of linoleic acid (ω-6 fatty acid) and at least one source of α-linolenic acid (ω-3 fatty acid). Dietary Supplement that is claimed in accordance with the present invention also contains at least one source of DHA (ω-3 fatty acid).

According to certain variants of implementation of the present invention, the number of lipids and their typical composition in the mixture are selected so that the ratio of ω-6:ω-3 fatty acids in the food additive was approximately 6:1 or less, about 5:1 or less, about 4:1 or less, about 3:1 or less, about 2:1 or less, or about 1:1 or less. According to some variants of implementation of the present invention, the ratio of ω-6:ω-3 fatty acids in the food additive is 6:1 or less. According to other variants of implementation of the present invention, the ratio of ω-6:ω-3 fatty acids in the food additive ranges from about 1:1 to 6:1, or from about 3:1 to 6:1. According to other variants of implementation of the present invention, the ratio of ω-6:ω-3 fatty acids in the food additive is from about 5:1 to 6:1. According to an additional variant of implementation of the present invention, the ratio of ω-6:ω-3 fatty sour is in the food additive is approximately 6:1. According to another variant implementation of the present invention, the ratio of ω-6:ω-3 fatty acids in the food additive is about 5:1.

For example, according to some aspects of the present invention nutritional Supplement contains a blend comprising: 1) at least one source of ω-3 fatty acid, linoleic acid, 2) at least one source of ω-6 fatty acids, ω-6, α-linolenic acid, 3) at least one source of ω-3 fatty acid, DHA, and the ratio of the total amount of ω-6 fatty acid to the total amount of ω-3 fatty acids is approximately 6:1 or less.

Suitable sources of oils rich in linoleic acid, are, without limitation specified, sunflower oil, cottonseed oil, walnut oil, oil soya bean oil, wheat germ oil, chestnut oil, pumpkin seeds, sesame oil, Brazil nut oil, peanut oil, safflower oil, corn oil, animal fat, and mixtures thereof.

Suitable sources of oils that are rich in α-linolenic acid, are, without limitation specified, Flaxseed oil, canola oil, butter beans, soybean, walnut oil, wheat germ oil, and mixtures thereof.

Suitable sources of DHA are, without limitation specified, the products of daily consumption, such as eggs (for example, oil of egg yolk and fat butter; oil seafood and fish, such as cod, salmon, herring, sardines, tuna and many other fish; fat brains, animal fats (e.g., beef or chicken), offal, pork fat, lard; and microbial oils, such as fungal oil or algae oil, described in detail in U.S. patent number 5,347,657; 5,550,156 and 5,658, 767. Each of these patents is hereby incorporated into this description by reference.

DHA, which is suitable for use in accordance with the present invention may be selected from any single-celled organism, if it contains a sufficient amount of DHA. To these organisms include, for example, oil mushrooms, various algae (in particular, the members of the class Dinophyceae, Bacillariophyceae, Chlorophyceae, Prymnesiophyceae and Euglenophyceae), as well as organisms of uncertain taxonomy, such as Thraustochytrium or Schizochytrium. Suitable methods of allocation of DHA-containing lipids of organisms Thraustochytrium or Schizochytrium described in U.S. patent number 5,130,242, which is included in the present description by reference.

Oil algae, such as dinoflagellates of the class Dinophyceae, in particular of the species Crypthecodinium cohnii, can be suitable sources of DHA (including DHASCO™ and DHASCO-S™), which is disclosed in U.S. patent number 5,397,591; 5,407,957; 5,492,938 and 5,711,983, all patents included in the present description as a reference. For example, Crypthecodinium cohnii is used to produce DA in very large quantities. The specified organism can be grown on a large scale biomass be used to obtain the DHA-containing oil. Suitable methods of obtaining DHA-containing biomass from .cohnii described in U.S. patent number 5,397,591 and 5,492,938, which are included in the present description as a reference.

Dietary Supplement that is claimed in accordance with the present invention may also contain a new source of DHA, obtained by synthesis or by genetic modification of various organisms, such as vegetables and/or plants containing oil. For example, many organisms were detected genes desaturase and elongase, which can be embedded into the plant cells or other cells of the host, which causes these organisms to produce DHA-containing lipids in large quantities, it is not very expensive technique. Thus, the present invention also relates to the use of these synthetic or recombinant DHA-containing lipids.

According to some aspects of the present invention is a food additive contains a mixture of sources of lipids, including two or more of the following oils: canola oil, the oil of soybeans, high class sunflower oil (HoSun), MCT oil (medium-chain triglycerides), corn oil; according to certain variants of the implementation of this izobreteniyami consists of all these five oils. According to another aspect of the present invention the mixture of the source of lipids includes canola oil, the oil of soybeans, high class sunflower oil, oil of medium-chain triglycerides (MCT) and corn oil, in combination with oil containing DHA, the ratio of ω-6:ω-3 fatty acids is approximately 6:1 or less.

According to some aspects of the present invention nutritional Supplement also contains other ingredients, in addition to carbohydrates, proteins, lipids and sources of DHA, as described above, such as minerals, vitamins, antioxidants, dietary fibre, flavouring agents, colouring agents, preservatives, emulsifiers and other biologically active substances, and mixtures thereof.

The methods and compositions claimed in accordance with the present invention, may involve the presence of one or more vitamin or its derivative, including, without limitation specified, Biotin, vitamin B1, thiamin, thiamin pyrophosphate, vitamin B2, Riboflavin, flavin mononucleotide, flavin-adenindinucleotide, pyridoxine hydrochloride, thiamine Mononitrate, folic acid, vitamin B3, Niacin, nicotinic acid, nicotinamide, Niacinamide, nicotinamide adenindinucleotide, tryptophan, Biotin, Pantothenic acid, vitamin B6, vitamin B12, cobalamin, methylcobalamin, deoxyadenosylcobalamin, cyanocobalamin, calcium Pantothenate, who antenova acid, vitamin C, ascorbic acid, vitamin a, retinol, retinal, retinoic acid, beta-carotene, vitamin D, vitamin D3, calciferol, cholecalciferol, dihydroxy-vitamin D, 1,25-dihydroxycholecalciferol, 7-dehydrocholesterol, choline, vitamin E acetate vitamin E, vitamin K, menadione, menechino, phylloquinone, naphthoquinone and mixtures thereof.

The methods and compositions claimed in accordance with the present invention, may involve the presence of one or more mineral or its derivative, including, without limitation specified, phosphorus, potassium, sulfur, sodium, docusinate sodium, chlorine, manganese, magnesium, stearate, magnesium carbonate, magnesium oxide, magnesium hydroxide, magnesium sulfate, copper sulfate, copper, iodine, boron, zinc, zinc oxide, chromium, molybdenum, iron, carbonyl iron, iron oxide, fumarate iron polysaccharide iron, fluorine, selenium, molybdenum, phosphate, or calcium acetate, potassium phosphate, oxide, or magnesium sulfate, sodium chloride, chloride or acetate of potassium, phosphate of iron, acetate, alpha-tocopherol, sulfate or zinc oxide, copper gluconate, chloride or picolinate chromium, potassium iodide, sodium selenate, sodium molybdate, phylloquinone, ciankobalamin, sodium Selenite, copper sulfate, Inositol, potassium iodide, cobalt and mixtures thereof. Examples of derivatives of mineral compounds include, without limitation specified, various salts, alkaline salts, complex EF the market and chelates of any mineral compounds.

Minerals can be entered in the food additive in the form of salts, such as calcium phosphate, glycerophosphate calcium, sodium citrate, potassium chloride, potassium phosphate, magnesium phosphate, ferrous sulfate, zinc sulfate, copper sulfate, manganese sulfate and sodium Selenite. Additional vitamins and minerals added to the composition according to procedures well known to specialists in this field.

The methods and compositions claimed in accordance with the present invention, may involve the presence of one or more flavouring agent, including, without limitation specified, extracts, flavoring agents, volatile oils, agents with the smell of cocoa or chocolate, peanut butter, bread crumbs, vanilla flavouring and any other available flavouring agent. Examples of suitable flavoring agents include, without limitation specified, pure anise extract, banana extract, cherry extract, chocolate extract, pure lemon extract, pure orange extract, pure peppermint extract, pineapple extract, rum extract, strawberry extract, or vanilla extract; or volatile oils, such as balsamic oil, Bay oil, bergamot oil, cedar oil, cherry oil, cinnamon oil, clove oil or peppermint oil; peanut butter, chocolate flavouring, vanillin the th flavor butterscotch, glaze, and mixtures thereof. The type and amount of flavoring agent is adjusted individually according to the method well known to specialists in this field.

The methods and compositions claimed in accordance with the present invention, may involve the presence of one or more emulsifier, which is added to impart stability to the final product. To suitable emulsifiers include, without limitation specified, lecithin (e.g., isolated from eggs or soy) and/or mono - and diglycerides, and mixtures thereof. Other suitable emulsifiers are well known to specialists in this field, the choice of a suitable emulsifier depends in part on the composition of the final product.

The methods and compositions claimed in accordance with the present invention, may involve the presence of one or more preservative that is added to food additives to increase shelf life. Suitable preservatives include, without limitation specified, potassium sorbate, sodium sorbate, sodium benzoate, sodium benzoate and calcium disodium EDTA mixtures thereof.

The methods and compositions claimed in accordance with the present invention, may involve the presence of one or more source of dietary fiber, including, without limitation specified, fiber, soybean fiber pods of peas, Arabian gum, and mixtures thereof. Food is obaka, declared in accordance with the present invention, may include any source of dietary fiber, which can be natural, synthetic or obtained by genetic modification of organisms specified source well studied.

The methods and compositions claimed in accordance with the present invention, may involve the presence of one or more of the stabilizer. Suitable stabilizers for use in accordance with the methods and compositions of the present invention are, without limitation specified, gum Arabic, gum karaya, gum, ghatti, tragacanth gum, agar, furcellaran, guar gum, Gellan gum, gum beans carob, pectin, low methoxyl pectin, gelatin, microcrystalline cellulose, CMC (sodium carboxymethylcellulose, methylcellulose, the hypromellose, hydroxypropylcellulose, DATEM (esters diacetyl-tartaroo acids and mono - and diglycerides), dextrans, carragenan, and mixtures thereof.

With the exception of ω-6 and ω-3 fatty acids, a number of other of the above ingredients food additives stated in accordance with the present invention, is chosen according to techniques well known to specialists in this field.

For example, the carbohydrates present in the food additive, as claimed in accordance the present invention, in amounts that vary from about 1 gram (g) per 100 kilocalories (kcal) to about 50 g/100 kcal. According to other variants of implementation of the present invention the amount of carbohydrates varies from about 5 g/100 kcal to about 25 g/100 kcal. According to another variant implementation of the present invention, the amount of carbohydrate is from about 10 g/100 kcal to about 15 g/100 kcal. According to some variants of implementation of the present invention, the amount of carbohydrate in the food additive as claimed in accordance with the present invention, is approximately 12.8 g/100 kcal.

The amount of protein in the food additive as claimed in accordance with the present invention may vary from about 0.1 g/100 kcal to about 20 g/100 kcal. According to other variants of implementation of the present invention, the amount of protein in the food additive is from about 0.5 g/100 kcal to about 10 g/100 kcal. According to other variants of implementation of the present invention the amount of protein is from about 1 g/100 kcal to about 5 g/100 kcal. According to some variants of implementation of the present invention the amount of protein in the food additive, as claimed in accordance with the present invention, is priblizitelen is 2.8 g/100 kcal.

The number of lipids in the food additive as claimed in accordance with the present invention may vary from about 0.1 g/100 kcal to about 50 g/100 kcal. According to other variants of implementation of the present invention, the number of lipids in the food additive is from about 1 g/100 kcal to about 20 g/100 kcal. According to other variants of implementation of the present invention, the amount of lipids is approximately 2 g/100 kcal to about 10 g/100 kcal. According to some variants of implementation of the present invention, the number of lipids in the food additive, as claimed in accordance with the present invention, is approximately 4.2 g/100 kcal.

If the source of lipids includes linoleic acid, the amount of the food additive as claimed in accordance with the present invention is approximately from 0.1 g/100 kcal to about 20 g/100 kcal. According to other variants of implementation of the present invention, the amount of linoleic acid in the food additive is from about 0.5 g/100 kcal to about 5 g/100 kcal. According to other variants of implementation of the present invention, the amount of linoleic acid is from about 0.75 g/100 kcal to about 2 g/100 kcal. According to some variants of the implementation of the infusion is his invention, the amount of linoleic acid in the food additive, declared in accordance with the present invention, is approximately 1 g/100 kcal.

If the source of lipids contains α-linolenic acid, the amount of the food additive as claimed in accordance with the present invention, is from about 0.01 g/100 kcal to about 10 g/100 kcal. According to other variants of implementation of the present invention, the amount of α-linolenic acid in the food additive is from about 0.05 g/100 kcal to about 1 g/100 kcal. According to other variants of implementation of the present invention, the amount of α-linolenic acid is from about 0.1 g/100 kcal to about 0.2 g/100 kcal. According to some variants of implementation of the present invention, the amount of α-linolenic acid in the food additive as claimed in accordance with the present invention, is approximately 0.16 g/100 kcal.

The amount of DHA in the food additive as claimed in accordance with the present invention may vary from 0.1 milligram (mg) per 100 kcal to about 1 g/100 kcal. According to other variants of implementation of the present invention, the amount of DHA in the food additive is from about 1 mg/100 kcal to about 200 mg/100 kcal. According to other variants of implementation of the present invention, the amount of DHA is app is siteline from 5 mg/100 kcal to about 50 mg/100 kcal. According to other variants of implementation of the present invention, the amount of DHA is from about 7.5 mg/100 kcal to about 25 mg/100 kcal. According to certain variants of implementation of the present invention, the amount of DHA in the food additive as claimed in accordance with the present invention, is approximately 17 mg/100 kcal. The amount of DHA in the food additive as claimed in accordance with the present invention, varies in different limits depending on the caloric content of food additives.

According to some variants of the implementation of the methods and food additives of the present invention, the amount of DHA is important. Used herein, the terms "significant level" or "significant levels" refers to the amount of DHA, which has a beneficial effect on the health of the subject, no matter how specified a beneficial effect is pronounced. Indicated a beneficial effect implies, without limitation specified, improving diet, increasing physical development, improve brain function and/or development of vision, improved immune system function, and improve overall condition and function of the cardiovascular system.

According to other aspects of the present invention is a food additive may contain a mixture of lipids, including, in novom the ratio of the total lipid content (wt./wt.%), approximately 10:% to about 50% canola oil, about 40% of the high class of sunflower oil, from about 5% to 40% oil triglycerides medium-chain (MCT), from about 1% to about 20% corn oil and from about 0.1% to about 10% source of DHA. According to one variant of implementation of the present invention, the ratio of ω-6:ω-3 fatty acids in the specified food additive is approximately 6:1 or less.

The term "weight ratio" or its abbreviation "wt.%" or "weight./wt.", used here, refers to weight ratio in percent of the total weight of one component of a food additive, which is revealed in the text, or of the total weight of all food additives in its final form with all the included ingredients.

According to other aspects of the present invention is a food additive, as claimed in accordance with the present invention, may include a mixture of sources of lipids, including, in weight./wt.% the total weight of lipids, approximately 29.3% canola oil, about 20.7% soybean oil, about 20.5% high class of sunflower oil, approximately 19.8% oil triglycerides medium chain, approximately 8.8% of corn oil and approximately 0.9% source DHA. According to another variant implementation of this izobreteny the ratio of ω-6:ω-3 fatty acids in the specified food additive is approximately 6:1 or less.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of vitamin a, it is desirable amount is from about 1 μg/100 kcal to about 500 µg/100 kcal. More preferably, the amount of vitamin A, according to the methods and compositions claimed in accordance with the present invention, is approximately 70 µg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of vitamin D, it is desirable amount of approximately 0.1 ág/100 kcal to about 100 mg/100 kcal. More preferably, the amount of vitamin D, according to the methods and compositions claimed in accordance with the present invention, is approximately 1.24 µg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of vitamin E, it is desirable amount is about 0.1 mg/100 kcal. More preferably, the amount of vitamin E, according to the methods and compositions claimed in accordance with the present invention, is approximately 2.36 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, assume the presence of vitamin K, it is desirable number is closer the flax from 0.1 µg/100 kcal to about 100 mg/100 kcal. More preferably, the amount of vitamin K, according to the methods and compositions claimed in accordance with the present invention, is approximately 5.4 µg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of vitamin B1, it is desirable amount is from about 0.01 mg/100 kcal to about 10 mg/100 kcal. More preferably, the amount of vitamin B1, according to the methods and compositions claimed in accordance with the present invention, is approximately 0.16 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of vitamin B2, it is desirable amount is from about 0.01 mg/100 kcal to about 10 mg/100 kcal. More preferably, the amount of vitamin B2, according to the methods and compositions claimed in accordance with the present invention, is approximately 0.2 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of vitamin B6, it is desirable amount is from about 0.01 mg/100 kcal to about 10 mg/100 kcal. More preferably, the amount of vitamin B6, according to the methods and compositions claimed in accordance with the present invention, the composition is yet approximately 0.2 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of vitamin B12, it is desirable amount is from about 0.01 μg/100 kcal to about 10 mg/100 kcal. More preferably, the amount of vitamin B12, according to the methods and compositions claimed in accordance with the present invention, is approximately 0.56 µg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of Niacin, it is desirable amount is from about 0.1 mg/100 kcal to about 100 mg/100 kcal. More preferably, the amount of Niacin, according to the methods and compositions claimed in accordance with the present invention, is approximately 2.45 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of folic acid, it is desirable amount is from about 0.1 μg/100 kcal to about 500 µg/100 kcal. More preferably, the amount of folic acid, according to methods and compositions claimed in accordance with the present invention, is approximately 20 µg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of Pantothenic what islote, it is desirable amount is from about 0.1 mg/100 kcal to about 100 mg/100 kcal. More preferably, the amount of Pantothenic acid, according to methods and compositions claimed in accordance with the present invention, is approximately 1.24 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of Biotin, it is desirable amount is from about 0.1 μg/100 kcal to about 100 mg/100 kcal. More preferably, the amount of Biotin, according to the methods and compositions claimed in accordance with the present invention, is approximately 15.2 µg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, assume the presence of vitamin C, it is desirable amount is from about 0.01 mg/100 kcal to about 1 g/100 kcal. More preferably, the amount of vitamin C, according to the methods and compositions claimed in accordance with the present invention, is approximately 2.32 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of choline, it is desirable amount is from about 0.1 mg/100 kcal to about 500 mg/100 kcal. More preferably, the amount of Holi is a, according to the methods and compositions claimed in accordance with the present invention, is approximately 25.2 mg/100 kcal,

If methods and/or compositions claimed in accordance with the present invention, imply the presence of Inositol, it is desirable amount is from about 0.1 mg/100 kcal to about 500 mg/100 kcal. More preferably, the amount of Inositol, according to the methods and compositions claimed in accordance with the present invention, is approximately 6.8 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of taurine, it is desirable amount is from about 0.1 mg/100 kcal to about 500 mg/100 kcal. More preferably, the amount of taurine, according to the methods and compositions claimed in accordance with the present invention, is approximately 6 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of carnitine, it is desirable amount is from about 0.1 mg/100 kcal to about 500 µg/100 kcal. More preferably, the amount of carnitine, according to the methods and compositions claimed in accordance with the present invention, is approximately 6 mg/100 kcal.

If methods and/or the composition, declared in accordance with the present invention, imply the presence of calcium, it is desirable amount is from about 0.1 mg/100 kcal to about 1 g/100 kcal. More preferably, the amount of calcium, according to the methods and compositions claimed in accordance with the present invention, is approximately 96 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of phosphorus, it is desirable amount is from about 0.1 mg/100 kcal to about 1 g/100 kcal. More preferably, the amount of phosphorus, according to the methods and compositions claimed in accordance with the present invention, is approximately 80 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of magnesium, it is desirable amount is from about 0.1 mg/100 kcal to about 500 mg/100 kcal. More preferably, the amount of magnesium, according to the methods and compositions claimed in accordance with the present invention, is approximately 14 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of iron, it is desirable amount is from about 0.1 mg/100 kcal to approx the tion of 100 mg/100 kcal. More preferably, the amount of iron, according to the methods and compositions claimed in accordance with the present invention, is approximately 1 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of zinc, the desirable amount is from about 0.1 mg/100 kcal to about 100 mg/100 kcal. More preferably, the amount of zinc, according to the methods and compositions claimed in accordance with the present invention, is approximately 1 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of manganese, it is desirable amount is from about 0.01 mg/100 kcal to about 10 mg/100 kcal. More preferably, the amount of manganese, according to the methods and compositions claimed in accordance with the present invention, is approximately 0.16 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of copper, it is desirable amount is from about 0.1 mg/100 kcal to about 1 mg/100 kcal. More preferably, the amount of copper, according to the methods and compositions claimed in accordance with the present invention, is approximately 80 µg/100 kcal.

what if the methods and/or compositions, declared in accordance with the present invention, imply the presence of iodine, it is desirable amount is from about 0.1 μg/100 kcal to about 100 mg/100 kcal. More preferably, the amount of iodine, according to the methods and compositions claimed in accordance with the present invention, is approximately 12 µg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of selenium, it is desirable amount is from about 0.01 μg/100 kcal to about 1 mg/100 kcal. More preferably, the amount of selenium, according to the methods and compositions claimed in accordance with the present invention, is approximately 3 µg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of sodium, it is desirable amount is from about 0.1 mg/100 kcal to about 500 mg/100 kcal. More preferably, the amount of sodium, according to the methods and compositions claimed in accordance with the present invention, is approximately 55 to 60 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of potassium, it is desirable amount is from about 0.1 mg/100 kcal to p is blithedale 1 g/100 kcal. More preferably, the amount of potassium, according to the methods and compositions claimed in accordance with the present invention, is approximately 180 mg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of chlorine, it is desirable amount is from about 0.1 mg/100 kcal to about 1 g/100 kcal. More preferably, the amount of chlorine, according to the methods and compositions claimed in accordance with the present invention, is approximately 70 mg/100 kcal. The amount of sodium, potassium and chlorine in food additives stated in accordance with the present invention, may vary depending on the total energy dietary supplements.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of chromium, it is desirable amount is from about 1 μg/100 kcal to about 500 µg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of molybdenum, it is desirable amount is from about 1 μg/100 kcal to about 500 µg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, imply the presence of fluorine, the desirable number of status is made approximately 1 µg/100 kcal to about 500 µg/100 kcal.

If methods and/or compositions claimed in accordance with the present invention, assume the presence of a source of dietary fiber, the amount of dietary fiber may vary from about 0.01 g/100 kcal to about 100 g/100 kcal. According to other variants of implementation of the present invention, the amount of dietary fiber is from about 0.1 g/100 kcal to about 10 g/100 kcal, or the amount of dietary fiber ranges from about 0.5 g/100 kcal to about 1 g/100 kcal. According to some variants of implementation of the present invention, the amount of dietary fiber is approximately 0.6 g/100 kcal.

Dietary Supplement that is claimed in accordance with the present invention, can also contain one or more prebiotic. The term "prebiotic" refers to biodegradable food ingredient that stimulates the growth and/or activity of probiotics. According to a variant of implementation of the present invention may be used any known prebiotic. To prebiotics, suitable for use in accordance with the present invention include, lactulose, galacto-oligosaccharide, fructo-oligosaccharide, isomalto-oligosaccharide, oligosaccharide soybean seeds, lactosucrose, Xylo-oligosaccharide, inulin, Polydextrose, gentio-oligosaccharide.

Food is th additive, declared in accordance with the present invention may also be administered to a subject in combination with a breast of a human or animal milk (e.g. cow's or goat's milk).

According to some variants of implementation of the present invention, one portion of a liquid food Supplement contains approximately 250 calories. According to another variant implementation of the present invention, one portion of a liquid food Supplement contains approximately 200 calories. According to another variant implementation of the present invention, one portion of the liquid food additive contains from about 150 to 200 calories. According to another variant implementation of the present invention, one portion of the liquid food additive contains from about 160 to 180 calories. According to another variant implementation of the present invention, one portion of a liquid food Supplement contains approximately 170 calories.

According to some variants of implementation of the present invention, one portion of liquid nutritional supplements calorie 250 kcal ensures the supply of approximately 7 to 20 mg/100 kcal DHA. Thus, if a child aged 1 to 10 years to feed declared a dietary Supplement, 2 to 4 times a day, it will additionally be obtained approximately from 35 to 200 mg DHA per day; thus, the current difference between the normal on the abuse DHA in the specified age group and recommended consumption will be offset.

According to other variants of implementation of the present invention, one portion of liquid nutritional supplements calorie 200 kcal ensures the supply of approximately from 7 to 75 mg/100 kcal DHA. According to another variant implementation of the present invention, one portion of liquid nutritional supplements calorie approximately from 150 to 250 kcal ensures the supply of approximately from 7 to 75 mg/100 kcal DHA. According to a particular variant of implementation of the present invention, one portion of liquid nutritional supplements calories from approximately 160 to 180 kcal ensures the supply of approximately from 7 to 75 mg/100 kcal DHA. According to another variant implementation of the present invention, one portion of liquid nutritional supplements calories 170 calories ensures the supply of approximately from 7 to 75 mg/100 kcal DHA.

According to certain variants of implementation of the present invention, one portion of food additive contains less than 200 calories, with specified dietary Supplement contains no artificial sweetener. According to another variant implementation of the present invention, one portion of food additive contains from about 150 to 200 kcal, with specified dietary Supplement contains no artificial sweetener. According to another variant implementation of the present invention, one portion of food EXT the file contains approximately 160 to 180 kcal, while specified dietary Supplement contains no artificial sweetener. According to another variant implementation of the present invention, one portion of food additives contains approximately 170 calories, with specified dietary Supplement contains no artificial sweetener.

Dietary Supplement that is claimed in accordance with the present invention, may be represented in any suitable form for use. For example, a food additive may be presented in liquid form, in the form of powder, concentrate liquid/powder form, ready to use, as well as in the form of kapley, tablets, pills, capsules, pudding, chewing tablets, soluble tablets, effervescent tablets, lyophilized powder, elixir, solution, suspension, emulsion, multilayer tablets, bilayer tablets, soft gelatin capsules, hard gelatin capsules, lozenges, chewable tablets, granules, pellets, particles, microparticles, dispersible granules, starch capsules, implants, depot implants swallow any forms, forms for injection, the form of infusions, cocktails, cookies, syrup, animal feed, health foods, cereals, flakes of glaze, food, soups and soup concentrates, foods, as well as their combinations.

However, according to a particular variant implementation is tvline of the present invention, a food additive is introduced in liquid form. Getting nutritional supplements in this form are carried out by methods well known to specialists in this field.

Dietary supplements are claimed in accordance with the present invention, is obtained using methods well known to specialists in this field. For example, for the production of dietary supplements in powder form, in a form ready for consumption, or in liquid form at the present time there are many ways.

Typically, these methods include the formation of a suspension of one or more solution, which typically contains water and one or more of these compounds: carbohydrates, proteins, lipids, stabilizers, vitamins and minerals. the pH of the suspension checked and if necessary adjusted to neutral, i.e. from 6.5 to 7.5, preferably to approximately 7.0. the pH of the suspension can be raised to the required using any acid or base that is compatible with the present composition, preferably with the aid of citric acid, potassium hydroxide or dibasic phosphate.

Then the suspension emuleret, homogenize and cool. Various other solutions can be added to the suspension before its further processing and during processing and after it. According to certain variants of the implementation of this izaberete the Oia liquid dietary Supplement is sterile. According to a variant of implementation of the present invention a food additive sterilized under aseptic conditions, then it can be diluted for use as the basis for a form ready for use or to be stored in liquid form or in powder form. Homogenization and sterilization mixture is performed using standard equipment, well known to specialists in this field.

If it is assumed that a dietary Supplement in final form should be a ready to use liquid or concentrated liquid, the desired amount of water added before sterilization. If it is assumed that a dietary Supplement in final form must be a powder, a suspension is heated and dried to obtain powder. The resulting dried powder can be mixed with other ingredients. A food additive may be optionally packaged for distribution and sale by using standard equipment known to specialists in this field.

Embodiments of any of the above mentioned methods are well known and obvious to specialists in this field. It is implied that the nature and scope of the present invention is not limited to any specific method of obtaining nutritional supplements.

In, not only is the R following examples describe some embodiments of the present invention. Other embodiments of the present invention, within the following claims, will be obvious to experts in this field. Assume that the specific embodiments of the present invention, and examples of their implementation are presented solely for the purpose of illustration and better understanding of the present invention and are within the following claims of the invention without limiting its scope and nature. In all examples presented here, if not stated otherwise, all data are expressed in percent by weight.

EXAMPLE 1

This example illustrates one way of implementing liquid dietary supplements are claimed in accordance with the present invention. Table 1 shows the ingredients of the claimed liquid food additives and their amounts in grams (g) or milligrams (mg), expressed per 1 liter (l). Table 2 presents the number of essential nutrients (proteins, lipids, carbohydrates, and vitamins and minerals contained in 8 fluid ounces of the claimed supplements. For this composition the number of calories per 8 fluid ounces liquid declared supplements is approximately 250 kcal.

Table 1
The ingredients and their concentration (per liter)
Ingredient, unit of measurePer liter
Sucrose, g115.27
Maltodextrin, DE15, g55.00
Concentrate milk protein, g35.00
A nourishing blend of oils (canola oil, corn oil and high class sunflower oil)25.50
Soybean oil, g9.00
MCT oil, g8.65
Natural and synthetic flavoring, g3.83
Potassium citrate, g2.00
Sodium ascorbate mg719.60
Corn syrup mg404.28
Inositol, mg104.72
Taurine, mg76.16
Niacinamide mg29.68
Biotin, homogenized, mg22.82
Calcium Pantothenate mg22.12
Vitamin B12 mg9.48
Hydroxide pyridoxine, mg4.34
Thiamine hydrochloride mg3.25
Riboflavin, mg3.08
Folic acid mg0.28
Iodide of potassium mg0.20
Potassium phosphate, dibasic, mg1300.00
Magnesium chloride, mg1280.00
Calcium phosphate, trehosnovnoy mg1250.00
Sodium chloride, mg540.00
Lecithin mg440.00
DHA oil unicellular organisms mg430.00
Choline chloride mg400.00
Carragenan-To-100, mg 125.00
Tocopherol acetate mg48.65
Canola oil, mgAt 36.56
Vitamin a, palmitate, mg1.35
Concentrate cholecalciferol mg0.83
Vitamin K1, liquid phytonadione mg0.11
Carnitine, mg80.00
Ferrous sulfate, mg63.00
Zinc sulfate, monohydrate mg33.51
Corn syrup mg11.52
Manganese sulfate, monohydrate mg5.63
Copper sulfate, mg4.79
Chloride chromium uranyl mg0.31
The sodium molybdate, dihydrate mg0.15
Sodium Selenite, mg0.08

Table 2
Nutrients
Nutrient units8 FL oz
Proteins, g7.1
Lipids, g10.5
Saturated lipids, g3
Cholesterol mg<5
Linoleic acid, g2.5
Alpha-linolenic acid, g0.4
DHA, mg43
Carbohydrates, g32
Vitamin A, ME420
Vitamin D, ME125
Vitamin E, ME8.8
Vitamin K, mcg14
Thiamine (Vitamin B1), mg0.4
Riboflavin (Vitamin B2), mg0.5
Pyridoxine, mg0.5
Vitamin B12, mcg1.4
Niacin, mg4.9
Folic acid, mcg1.4
Pantothenic acid mg3.1
Biotin, mcg38
Choline, mg63
Vitamin C mg58
Calcium, mg240
Phosphorus mg200
Magnesium, mg40
Sodium, mg88
Potassium, mg310
Chlorine mg175
Iodine mg30
Iron mg2.5
Zinc mg2.5
Manganese, mg0.4
Copper mg0.2
Selenium, mcg7.5
Chromium, mcg12.5
Molybdenum, mcg12.5
Taurine, mg15
L-carnitine, mg15
Inositol, mg20

Table 3 presents the concentrations of the respective components of food additive described in Example 1, expressed in grams per liter.

Table 3
The concentration of components (per liter)
Components, unitsPer liter
Proteins, g30
Carbohydrates, g135
Lipids, g44
Linoleic acid, g10.6
α-Linolenic acid, g 1.7
Docosahexaenoic acid, g0.18

The distribution of calories in the food additive described in Example 1 are shown in Table 4.

Table 4
The distribution of calories
ComponentCalories, percent
Proteins11%
Lipids38%
Carbohydrates51%

The following Table 5 presents the content of LCPUFAs in the food additive obtained in Example 1.

Table 5
LCPUFA
LCPUFA% weight./weight. from the total lipid content% of total calories
Linoleic acid (LA)24.1%9.06%
α-linolenic acid (ALA)3.9%Docosahexaenoic acid (DHA)0.41%0.154%

EXAMPLE 2

This example illustrates another variant of implementation of liquid nutritional supplements, announced in accordance with the present invention. Table 6 presents the ingredients of the claimed liquid food composition, the number of which is expressed in the weight ratio of the total weight of all food additives. Table 7 presents the number of essential nutrients (proteins, fats and carbohydrates), as well as vitamins and minerals contained in 8 fluid ounces of the claimed supplements. In this example, the content of calories per 8 fluid ounces liquid nutritional supplements is about 170 kcal.

Table 6
The ingredients and their concentration (per liter)
Ingredient, gPer liter
Skim milk, condensed matter170
Sucrose42.0
Fructose, crystallized35.0
italina mixture of lipids (canola oil, corn oil and high class sunflower oil)31.3
Cocoa powder9.0
The concentrate of whey proteins5.0
The sodium Caseinate3.0
DHA oil unicellular organisms mg1.45
Calcium phosphate, trehosnovnoy1.10
Natural and synthetic flavoring0.50
Concentrate lecithin0.50
Guar gum0.35
Mono - and Diglycerides0.30
Sodium ascorbate0.15
Corn syrup0.08
Niacinamide0.03
Biotin homogenized0.02
Calcium Pantothenate0.004
Pyridoxine hydrochloride0.002
Thiamine hydrochloride0.002
Riboflavin0.0007
Folic acid0.0003
Carragenan To-1000.25
Sodium chloride0.25
The magnesium phosphate, dibasic0.15
The copper sulfate0.02
Corn syrup0.002
The pyrophosphate of iron0.03
Soybean oil0.02
Tocopherol acetate, DL-alpha0.004
Vitamin a palmitate0.003
Concentrate cholecalciferol0.0002

Table 7
Nutrients
Ingredient units8 FL oz
Calories kcal170
Proteins, g6
Lipids, g5
Saturated lipids, g0.7
Cholesterol mg0

Linoleic acid, g1.0
Alpha-Linolenic acid, g0.2
DHA, mg130
Carbohydrates, g25
Vitamin A, ME820
Vitamin D, ME48
Vitamin E, ME2.7
Thiamine (Vitamin B1), mg0.32
Riboflavin (Vitamin B2), mg0.36
Pyridoxine, mg0.36
Vitamin B12, mcg0.2
Niacin, mg5.8
Folic acid, mcg70
Pantothenic acid mg1.3
Biotin, mcg30
Vitamin C mg10
Calcium, mg270
Phosphorus mg210
Magnesium, mg38
Sodium, mg95
Potassium, mg320
Chlorine mg180
Iodine mg70
Iron mg2.7
Zinc mg2.5
Manganese, mg0.79
Copper mg0.3

Table 8 presents the concentration of the respective components of p the food additives, obtained in Example 2, expressed in grams per liter.

Table 8
The concentration of components (per liter)
Component unitsPer liter
Proteins, g25.3
Carbohydrates, g105
Lipids, g21.1

The distribution of calories in the food additive, obtained in Example 2 are presented in Table 9.

Table 9
The distribution of calories
ComponentCalories, percent
Proteins14%
Carbohydrates59%
Lipids27%

EXAMPLE 3

This example describes the process of obtaining food additives stated in accordance with the present invention.

The composition of a variant of dietary supplements, Appl is authorized in accordance with the present invention, presented in Table 1 (list of components). In this embodiment, the source of protein is a concentrate of milk proteins, which is a mixture of casein and whey protein in a ratio of 8:2. Source of lipids is a mixture of the following lipid components (in wt./wt.% the total weight of lipid): 29.3% canola oil, 20.7% soybean oil, 20.5% high class of sunflower oil, 19.8% oil triglycerides medium chain, 8.8% corn oil and 0.9% oil DHA. The content of DHA in the specified composition is approximately 17 mg/100 kcal. The source of carbohydrate is a mixture of maltodextrin and sucrose. The composition also contains required amount of carrageenan and flavouring agent.

The process by which it is possible to obtain a liquid dietary Supplement that is claimed in accordance with the present invention includes the following steps:

1. The mixture of proteins and a mixture of carbohydrates is dispersed in water at room temperature with good stirring.

2. the pH of the resulting dispersion was adjusted to approximately 7 with potassium hydroxide.

3. All the vitamins and minerals dissolve in water, pre-heated to approximately 170°F, the resulting solution was added to the dispersion of proteins/carbohydrates.

4. the pH of the mixture is again brought to 7.

5. The mixture of lipids is heated to approximately 180°F and ZAT is added to the suspension of carbohydrates/proteins/vitamins and minerals with good stirring. At this stage you can add all of the desired ingredients.

6. The mixture is then heated over an open couple to 225°F for 45 seconds and then rapidly cooled to 160°F.

7. The mixture is then homogenized twice using a two-stage homogenizer with a total pressure of 3000 pounds per square inch (psig)2500 psig in the first stage and 500 psig in the second stage.

8. The mixture is then sterilized under aseptic conditions at 268°F for 5 seconds at a pressure of 2000 psig, then Packed by setting to Dole aseptic canning, model 1305.

Disclosed in the description and other modifications and variations of the present invention can be carried out by a specialist in this field of knowledge without going beyond the scope of the invention, which is reflected in the claims. In addition, it should be clear that various aspects and embodiments of the invention can be partially or completely modified without changing its essence. Specialist in this field is also clear that given in this application is the description of the invention serves only for illustrative purposes and in no way limits the scope of the invention, the essence of which is expressed in the formula. Thus, the content and breadth of the claims of the claims is not limited to the description that characterizes the preferred embodiment of the invention.

1. Pisew which I Supplement for children contains:
the protein component;
source of vitamins and minerals in quantities sufficient to meet the daily needs of the child aged from one year to 13 years;
carbohydrate component; and
the lipid component comprising a source of docosahexaenoic acid (DHA), at least one source of linoleic acid and at least one source of α-linolenic acid, and the ratio of ω-6:ω-3 fatty acids is between 6:1 and less.

2. Food additive according to claim 1, which is in a liquid form.

3. Food additive according to claim 1, in which the source of the carbohydrate is a mixture of maltodextrin and sucrose.

4. Food additive according to claim 1, in which the source of protein is a concentrate of milk proteins.

5. Food additive according to claim 1, in which the lipid component is a mixture of canola oil, soybean oil, high class sunflower oil, vegetable oil triglycerides, medium-chain (MCT) and corn oil.

6. Food additive according to claim 1, which contains DHA in the amount of approximately from 0.1 mg per 100 kcal of food additives up to about 1 g per 100 kcal of food additives.

7. Food additive according to claim 1, which contains DHA in the amount of about 7.5 mg per 100 kcal of food additives up to about 25 mg per 100 kcal of food additives.

8. Food additive according to claim 1, which contains a DH in number, approximately 17 mg / 100 kcal of food additives.

9. Food additive according to claim 1, which further comprises at least one prebiotic.

10. Food additive according to claim 9, in which the prebiotic is selected from the group comprising: lactulose, galactooligosaccharide, fructooligosaccharide, isomaltooligosaccharide, soy oligosaccharides, lactosucrose, xylooligosaccharide, inulin, Polydextrose and histiological.

11. Food additive according to claim 1, one portion of which contains approximately 250 kcal.

12. Food additive according to claim 1, one portion of which contains approximately from 160 to 180 kcal.

13. Dietary Supplement for children, containing:
the protein component;
carbohydrate component;
the lipid component comprising (in wt.% the total weight of the lipid component)
approximately, 10% to 50% canola oil;
approximately, 5% to 40% soybean oil;
approximately, 5% to 40% high class of sunflower oil;
approximately, 5% to 40% oil triglycerides medium chain;
approximately from 1% to 20% corn oil; and
approximately from 0.1% to 10% of the source of docosahexaenoic acid (DHA).

14. The food additive according to item 13, in which the lipid component comprises (in wt.% the total weight of the lipid component):
29,3% canola oil;
20.7% of soybean oil;
20,5% high class of sunflower oil;
19.8% of oil trigly is erodov secondary circuits;
8,8% corn oil; and
0.9% source of docosahexaenoic acid (DHA).



 

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Ketogenic diet // 2433748

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1 tbl, 1 ex

Ketogenic diet // 2433748

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