Ketogenic diet

FIELD: food industry.

SUBSTANCE: invention relates to food industry, in particular, to a food product which may be used in ketogenic diet. One proposes a solid or semisolid nutritive composition including proteins, lipids and digestible carbohydrates. The components are produced of at least two different sources; the composition formula ensures 2520-3080 kilojoules per 100 g of dry substance. Lipids weight ratio to the sum total of proteins content and digestible carbohydrates is 2.6-3.8 to 1. The composition may be dissolved in water to produce a liquid food product.

EFFECT: invention allows to produce a product having a high level of ketogenic components applicable for feeding infants suffering from epilepsy.

14 cl, 1 tbl, 2 ex

 

The present invention relates to one delicious product that can be used as the ketogenic diet, suitable for enteral application of epileptic aged from birth to 12 months and includes small amounts of TRANS fatty acids, has a high calorific value and a relatively high amount of protein.

The human body gets needed energy mainly from food and metabolisable protein, lipid and digestible carbohydrates. In traditional Western diet digestible carbohydrates provide the greatest amount of energy, in most cases, more than 50 percent energy using a conversion factor of 4 kcal or 16.8 kJ per gram is at the expense of digestible protein, 9 kcal 37.8 kJ per gram due to lipids. In the metabolism of digestible carbohydrates are mainly excreted glucose, which is the preferred energy source for the human body. Under certain conditions, the most human cells can also use other organic compounds as energy sources, such as amino acids, fatty acids and ketones. Generally, it is believed that increasing the amount of carbohydrates relative to lipids reduces the ketogenic properties of products. Therefore, the classical ketogenic products for children, p is the giver of epilepsy, provides 4 times more lipids compared to the amount of protein and digestible carbohydrates, calculated from the total weight.

The ketogenic diet is a diet that provides after consumption, digestion and metabolism of ketones as the main source of energy. In particular, these ketone compounds include acetoacetate, D-3 hydroxybutyrate and acetone. Ketoacids, such as oxaloacetate, not calculated as ketone bodies. In particular, the ketogenic diet includes more than 60 g of lipids per 100 g of dry matter diet products, therefore, more than 77 percent energy.

The ketogenic diet is used to treat epileptic seizures in the treatment of obesity and weight optimization. Such diets can include many different dishes, each of which is suitable for a diet or may consist of one single product that can be used for the nutrition of man, when it is used as the only food. The product called Ketocal (Ketocal), belongs to the latter category and is used to combat epilepsy, in particular, with incurable epilepsy in young children. The product provides 100 g of dry matter 3011 kilojoules and includes per 100 g of dry matter 15,25 g protein, 73 g of lipids and 3 g of digestible carbohydrates. The amount of saturated fat kitty who is from about 22 wt.% triglyceride. However, too low amount of carbohydrates and the nature of the lipids make the product not optimal for human consumption. Therefore, an object of the present invention provides a highly effective product that has a more appealing taste, while providing a better lipid fraction in relation to the ketogenic properties, tolerance, security, and lower amounts of TRANS fats.

In EP 0843972 describes the finished product for enteral feeding people suffering from metabolic syndrome or hypertriglyceridemia, which includes 33-63 energy% fat and 5-30 EN.% protein from the composition and in which the fatty acids include 55-90 wt.% medium chain fatty acids, 5-25 wt.% polyunsaturated fatty acid and 0-30 wt.% other fatty acids. The levels of palmitic acid is very low, 0.5 to 1% of the total weight of fatty acids.

The problem to be solved by the present invention, relates to providing a nutrient mixture suitable for use as a full power input as dry, semi-solid or as the recovered liquid product and that essentially meets the needs of infants suffering from epilepsy, providing high levels ketogenic components, while avoiding the disadvantages of the products of the prior art.

A DETAILED description of the IMAGE IS ETENIA

According to the present invention this problem is solved by increasing the amount of digestible carbohydrates and selection of specific lipids in the quality of the ingredients. These lipids not only provide the right type of energy when catabolism, but also provide a relatively high amount of palmitic acid, which can be used for biosynthesis, in particular, in children suffering from epilepsy, which, as a rule, suffer from stunted growth.

The product of the present invention is a product which is suitable for full human nutrition, in particular infants and more specifically children suffering from epilepsy. Therefore, the product includes protein fraction, lipid fraction, the fraction of digestible carbohydrates, vitamin faction and faction minerals/trace elements and optional other components.

Protein fractions preferably includes peptides longer than 8 amino acids, which make the product unsuitable for parenteral administration because of potential allergic reactions. Preferably the mixture includes proteins that have a strong emulsifying properties, such as certain casein, which are known from the prior art. When using partially hydrolyzed proteins, it is preferable to include at IU is e 20% hydrolyzed whey, as shown below, to match the nutrient requirements. However, products that can be recovered in water or a liquid mixture, preferably should contain lysolecithin, tartaric esters, or combinations thereof as a stabilizing system to obtain a product suitable for drinking.

The product preferably is a solid, semi-solid product, such as powder, bars, pudding and the like. Under semi-solid product, you should understand the product with a solids content of more than 40 g per 100 g of ready-to-eat product. More preferred is a powder, which can be restored in the water to be used as the only complete food product. The powder may consist of primary particles, but also agglomerated primary particles or mixtures of particles of different sizes. Such powders can be obtained using methods known from the prior art, such as spray drying, in particular, when using auxiliary additives to improve flow characteristics.

The liquid used for feeding children suffering from epilepsy, have calorie 9-3,0 kcal/ml (3,8-of 12.6 kJ/ml), preferably 1.1 to 2.0 kcal/ml (4,6-of 8.4 kJ) and preferably 1,2-1,7 (5,0-7.2 kJ/ml). In particular, calories the ü mixture, used as a nutritionally complete mixture is 1.3-1.6 kcal/ml (5,4-6,7 kJ/ml). When the calorie liquid mixture is 8.4 to 12.6 kJ/ml, the product is also used for intermediate enrichment of food the patient.

When used in liquid, solid or semi-solid product as an intermediate supplementation of the food product preferably includes 100 kilojoules product more than 4.0, more preferably 8, more preferably 20-1000 mg added methyl donor selected from the group consisting of serine, choline, beaten, dimethylglycine, sarcosine, MSM and SAM.

Dry the product at least partially soluble in water, so that, if necessary, allows to obtain a ready to use liquid product. Preferably at least 50 wt.%, preferably at least 75 wt.% on the dry substance is soluble when dissolved in a 10% wt./about. solution in water at 20°C.

The product is a relatively high-calorie product to foodstuffs for infants. In particular, it provides 600-735 kcal or 2520-3080 and preferably 2800-3040 kJ per 100 g of dry matter. The weight ratio of lipids to proteins and digestible carbohydrates is 2.6 to 3.8 to 1, preferably 2.7 to 3.4, and more preferably from 2.7 to about 3 to one.

The amount of digestible uglev the Dov is 3.2-9, preferably 4-8,6, preferably 5-8,2 g per 100 g of dry matter. The amount of protein is 13-18, preferably 13,8-17, it is preferable to 14.2-16.2 g per 100 g of dry matter. The amount of lipids is 60 to 80, preferably 63-75, preferably 65-72 g per 100 g of dry matter.

Protein includes all the essential amino acids and, in particular, relatively high levels of lysine, leucine and sulfonylation, methionine or cysteine, to avoid or even to counteract delayed growth while ensuring the ketogenic diet. 100 g of protein the amount of leucine is, as a rule, more than 9.4 g, and more preferably to 10.2, Preferably lysine include more than 7,7, preferably more than 7.9 and nepredosuditelnaya more of 9.1 wt.% the protein. Also applies to methionine, that is, its amount is preferably more than 1.8 g, more preferably 2.2 g and more preferably more than 2.4 g per 100 g of product.

In particular, suitable include alpha-lactalbumin or ingredients, which include large quantities of this protein. The presence of more than 20 wt.% alpha-lactalbumin in the protein fraction of the product as a result allows you to more easily meet the requirements for Latino, lysine, methionine and cysteine, excellent taste attractiveness and digestibility. Preferably, more than the 20%, preferably 40-80 wt.% the protein fraction consists of alpha-lactalbumin.

The fraction of lipids may include triglycerides, diacylglyceride, monoacylglycerides, phospholipids, lysophospholipids, cholesterol and glycolipids. Despite the fact that you get a superior product in terms of effectiveness, safety and taste appeal by the inclusion of more than 97% of triglycerides as a source of lipids, digestibility can be improved by phospholipids, lysophospholipids, diacylglycerides and/or monoacylglycerides. This allows you to avoid constipation and to increase the bioavailability divalent cations, in particular calcium, magnesium and zinc. The substitution of at least 10% and preferably more than 14%, up to, for example, 25%, or preferably up to 20% (by weight) of triglycerides by one or more phospholipid, litestream, diacylglycerides and monoglyceride impact positively. The amount of phospholipids should be less than 14%, preferably less than 8% of the lipid fraction to avoid too high levels of phospholipids, which can affect the digestibility divalent cations.

Lipid fraction should include linoleic acid and alpha-linolenic acid. Together they provide more than 15 wt.%, in particular, more than 17 wt.%, lipids (total weight of fatty acids). Linol the Wai acid provides more than 14, preferably 15-25, in particular 16-21, energy % composition (using the factor of 37.8 kJ/g of fatty acids). Alpha-linolenic acid should provide at least 1,2 energy % of the composition.

The amount of polyunsaturated fatty acids (that is, having two or more unsaturated bond)that exclude TRANS fatty acid, is 16-40, preferably 20-30 g per 100 g of lipids. Preferably, the lipid fraction also included an ω-3 polyunsaturated fatty acids other than alpha-linolenic acid. In particular, polyunsaturated fatty acids include more than 0.5, preferably 1.0 to 10 wt.% docosahexaenoic acid. More preferably, the polyunsaturated fraction also included arachidonic acid in the amount of more than 1.0 wt.%, up to 6 wt.% fraction of polyunsaturated fatty acids. The amount of TRANS fatty acids is less than 20, preferably 0 to 10, preferably 0.2 to 4 g per 100 g

The amount of saturated fatty acids is relatively high. In particular, it must be from 23 to 50, preferably 25-45, preferably 33-44 g per 100 g of lipids to the total weight of fatty acids. Saturated fatty acids have from 8 to 24 carbon atoms. Preferably the main part of the saturated fatty acid is palmitic acid (C 16:0). Thus, palmitic sour is and provides for example, 15-50, preferably 18-45, preferably 23-44 g per 100 g of lipids. In a specific embodiment, the invention provides 30-37 g of palmitic acid per 100 g of lipids. Therefore, palm oil is the preferred source for at least 50%, preferably from 70 to 90% of the lipid fraction. The remaining fraction of the lipids may be selected from, for example, safflower, sesame, soybean or sunflower oil, or mixtures thereof, preferably soybean oil (preferably from 2 to 30), medium chain triglycerides (fatty acids having 8 to 14 carbon atoms, from 0 to 14), marine oil (preferably from 0 to 14 wt.%, preferably from 2 to 12 wt.%) and phospholipids, mono - and diglycerides.

An appropriate number of mono - and diglycerides of fatty acids ranges from 25 to 48, preferably 28-43, preferably 30-40 g per 100 g lipid (by weight of fatty acids).

A mixture of oils comprising one or more ingredient, preferably containing at least 2, 3, 4, 5, nepredosuditelnaya all of these ingredients are shown in Table 1, it was found that they are very suitable for use in preparation of the ketogenic diet.

Table 1
Mix ingredients for use in the ketogenic diet
EffectivePreferredMore pre-
reverent
Most preferred is
sory
Palm oil (oil)70-9070-90 RPO75-85 PO75-85 RPO
Vegetable
oil (oil)
2-302-30 RSBO10-20 VO10-20 SBO
MCT oil0-140-140-5
LCP oil (oil)0-140-141-12 of the 2 oils1-6 AO+FO
PL0-140-141-8 lecithins3-7 SBL
MG or DG0-140-141-20 DG1-20 DG

The number is given as weight % of the lipid fraction.

The reduction will amount is sniny below.

Palm oil (PO) refers to edible oils, soluble in diethyl ether, obtained from palm trees and includes crude oil from the fruit/nut palm or palm kernel, which includes >10% triglyceride compounds (NTG), such as carotenoids, terpenes, such as squalane or squalene, Tocopherols and steroids and refined oil (RPO) of nuts or kernels, or mixtures thereof. Therefore, NTG does not contain water or impurities ash, or material of cell walls.

Vegetable oil (VO) refers to the raw or edible oils derived from soy, safflower, canola, sunflower or linseed oil. SBO derived from soybean oil, and it may include various numbers of triglyceride material, such as a phospholipid. Purified SBO (RSBO) includes less than 10% triglyceride compounds (NTG).

MCT oil is an edible oil, known from the prior art, and includes more than 90 wt.% fatty acids which are saturated fatty acids with 8, 10 or 12 carbon atoms.

Phospholipids (PL) can be obtained from sources known from the prior art, such as eggs, soy or rapeseed oil and can provide a mixture of phosphatidylcholine and phosphatidylethanolamine and optional synthesised or phosphatidylserine.

LCP oil is what any cooking oil, with more than 15% of fatty acids with 20 or more carbon atoms. In particular, these oils include more than 15% docosahexaenoic acid or arachidonic acid. Suitable sources of such acids are marine oils such as fish oil (FO), oil, algae or yeast, fungi or organisms that have been genetically modified for the biosynthesis of these fatty acids, such as bacteria, yeast, plants or eggs from a special way fed birds or modified of birds.

The application of these lipids allows you to get a suitable profile of fatty acids with a low amount of TRANS fatty acids and allows you to get products well-tolerated infants or older suffering from epilepsy.

Fraction of digestible carbohydrates may include food ingredients, such as glucose syrup, maltodextrins, lactose, sucrose, galactose, ribose, and the like. Despite the fact that you are getting excellent products in terms of effectiveness, when applied to some other technical features, as described here, the best result to avoid side effects and effectiveness obtained if the fraction of digestible carbohydrates has a certain form. Preferably, if at least 20%, preferably 30-90% fraction of digestible carbohydrates obtained from sources the ICA galactose or ribose. Suitable for these purposes ingredient is lactose. In particular, when the consumption of such ketogenic mixture, which includes not glucose digested carbohydrates will be reduced oxidative stress.

Digestibility determined using the method of Englyst 1999.

Proteins, lipids and carbohydrates preferably receive at least two different sources, for example, proteins at least partially derived from an animal source, essentially milk, but not necessarily the part can be obtained from vegetable source, the lipid is at least partially derived from vegetable source, and carbohydrates are at least partially derived from a dairy source, or from a combination of milk source (lactose) and plant sources (glucose, maltodextrins, and the like).

The number of microingredients that should be included in the product meets the requirements of mixtures. However, the increase in the number of some specific ingredients above recommended improves efficiency and prevents side effects in children suffering from epilepsy.

For example, the amount of vitamin B6 should be above 0.8 mg, preferably 0.9 to 90 mg, nepredosuditelnaya 1.0 to 60 mg per 100 g of dry product, to improve efficiency and reduce negativegoing effects. This is essentially applicable when the product is used for children suffering from epilepsy, which is not intended to combat seizures. Suitable sources include pyridoxine, pyridoxamine and pyridoxal, including phosphates, or salts of these components. However, the use of pyridoxal preferable.

Another preferred ingredient of the composition is Biotin. Infants need 6-200, preferably 8-100, preferably 9-50 mcg per daily dose. This daily dose usually is 100 g of powder, which restores water to make 500 ml of the food product (20% solution) for 2 month-old infant. For 6 months of age, the dose is increased to 200 g of powder. In situations where the disorder is chronic, enteral product is consumed on a daily basis by patients suffering from metabolic syndrome, for prophylaxis of type II diabetes for the prevention or treatment of elevated levels of ketones in the plasma, the number of Biotin is preferably 50-1000, preferably 70-500, more preferably 80-300 mg per day for children older than 11 years and adult, 10-200, preferably 15-150, more preferably 18-100 mcg per day. In acute situations, such as acidosis, preferred a higher number. For example, the child starshe years and an adult is required 300-20000, preferably 360-2000, preferably 420-1000 mcg per daily dose. Infants younger age required 40-500, preferably 50-250, preferably 60 to 150 mcg. Premature children should be introduced 9-200, preferably 12-100 and preferably 15-50 µg per daily dose.

Therefore, preferably the composition contains Biotin 6 - 1000 μg, preferably 8-400 µg per 100 g of dry matter. For traditional mixtures, the preferred amount is 9-50, in particular 12-50 mcg per 100 g For specific purposes, such as acidosis, the preferred amount is 40-400, in particular 50-250 µg per 100 g of dry matter.

It was found that the Biotin in amounts according to the present invention increases the levels of ketone bodies in the blood plasma, the levels of AGE products and products Maiar in the tissues, and the degree of acidosis in a short time, for example, lactic acidosis, and for the normalization of the lipid profile, in particular, levels of cholesterol in the plasma.

Vitamin B 12 can be achieved by using appropriate sources, such as synthetic cyanocobalamin, methylcobalamin, adenosylcobalamin and hydroxycobalamin, for example, obtained from isolates of organs such as the liver, for example, water, the concentrate is subjected to lysis of hepatitas agricultural animals such as pigs, cows, chickens with a concentration of more than 75 µg cob is lamina per 100 ml of extract. Preferably the composition comprises vitamin B12 in the amount of 0.25 to 50 mg per 100 g of dry composition, preferably 0.4 to 10 µg and nepredosuditelnaya 0.8 to 5 g per 100 g of dry matter.

Preferably the amount of Pantothenic acid is more than 3, preferably 4-20, nepredosuditelnaya 4.5 to 14 mg per 100 g of dry matter.

100 g of dry product include more than 25 mg of L-carnitine and preferably 28-200 mg for improvements in energy generation from the product. Very suitable ingredients are alkylated carnitine, in particular N-acetyl carnitine or N-propyl or N-isopropyl carnitine.

The amount of calcium in the mixture is relatively high, i.e. more than 580 and preferably 600-900, preferably 620-750 mg per 100 g of dry matter. To provide greater bioavailability of calcium, the ratio of calcium to phosphorus is more than 1.1:1 and preferably 1.2 to 2:1. Preferably, the calcium salts are soluble salts, such as salts with organic anions.

The amount of taurine is preferably more than 35, preferably 45-200 mg per 100 g of dry product. Suitable sources of taurine are known from the prior art and include taurate.

Preferably, the product includes a source of nucleotides, nucleoside or nucleotide bases. These sources include synthetic, is such as uridine, citizen, adenine, including their salts, along with their phosphates, such as originalfotot, uridinediphosphate, along with extracts of yeast, algae, bacteria or other crops, or tissues that provide such features. Very suitable sources include UMP, CMP, and citicoline. Nucleotides or equivalent compounds preferably include the number of 2-600, preferably 6-100, nepredosuditelnaya 10-35 mg per 100 g of dry matter. Nepredosuditelnaya of uridine include in the amount of 2-50, preferably 4-30, preferably 7-12 mg per 100 g of dry powder.

Also preferably, the product includes oligosaccharides. In particular, in the amount of 10 mg to 2 g, preferably 40 mg to 1.8 g per 100 g of dry product. Suitable oligosaccharides include those which have a chain length of 3 to 20 monosaccharide units. Preferably such monosaccharides include at least two, but preferably at least three different monosaccharide from a group of galactose, fructose, fucose, mannose, arabinose, glucuronic acid, sialic acid, N-acetylglucosamine. Such mixtures can be obtained by the inclusion of pure oligosaccharides, or the inclusion of at least two mixed oligosaccharides, for example, β-galacto-oligosaccharides and fructo-oligosaccharides. The inclusion of such oligosaccharides reduces the immunological problems of patients, the IP is alsoused ketogenic diet, as the only food.

The product is effective for control, in particular in relation to the lower frequency of seizures in the short and long term and in reducing the severity of seizures. In particular, the mixture has a positive effect on infants with congenital metabolic disorders, with the exception of infants suffering from defects vectors glucose, and infants are not sensitive to protivopavodkovoj therapy. Undesirable side effects such as stunted growth, metabolic acidosis, decreased immune function, kidney problems are relatively low.

The product of the present invention can be applied to optimize the weights in accordance with the views of Dr. Atkins (Dr. Atkins) for adults with a BMI (BMI) above 25 and other persons with obesity and, in particular, persons with obesity, suffering from metabolic syndrome or insulin resistance. This is in particular true in the case when the product is used as the only power, and preferably when the compositions of the present invention consume, as a separate ready-to-eat products, of which at least two have different physical form in the form of liquid, semi-solid or solid.

The product after recovery to a liquid product suitable d is I introduction in an amount of from 50 to 200, preferably from 75 to 150 grams per day, calculated on the dry substance for infants younger than 12 months in accordance with the General recommendations of the energy consumption, such as described in the recommendations of the health authorities (for example, Gezondheidsraad 2000). For older children preferred daily amounts, calculated on the dry matter, 100 and 360, in particular from 150 to 300 For adults, these quantities are 100-500, nepredosuditelnaya 150-340 g to ensure the greatest energy at the expense of ketone bodies and at the same time a sufficient amount of essential amino acids, carbohydrate skeletons and other nutrients that are well tolerated and safe.

Example 1: Antiepileptic mix for kids

Information on the nutritional valuePer 100 g powder100 kcal*100
ml**
EnergykJ
kcal
2918
707
413
100
292
70,7
Proteing15,22,1 1,5
Carbohydrates like sugarg7,61,10,76
Fats, including
Rich
Monounsaturated
Polysaturated
g
g
g
g
68,4
25,4
23,6
16,4
the 9.76,8
% LCT100
Ratio
ω-6:ω-3 fatty acids
%energy from linoleic acid
%energy from α-linolenic acid
13,6
19,2
1,4
Fat: protein+
carbohydrates (g/d)
3:1
FiberNot added
*about 14.1 grams of powder
**10 g of diluted up to 100 ml

Typical amino acids the initial profile (g/100 g powder

L-alanine 0,5

L-arginine 0,53

L-aspartic acid 1,1

L-cysteine 0,42

L-glutamic acid 3,3

Glycine 0,29

L-histidine 0,46

L-isoleucine 0,75

L-leucine 1,5

L-lysine 1,2

L-methionine 0,43

L-phenylalanine 0,76

L-Proline 1,6

L-serine 0,81

L-threonine 0,73

L-tryptophan 0,41

L-tyrosine 0,81

L-valine 0,99

L-carnitine 0,03

Carbohydrate profileCarbohydrates (g/100 gPowder g/100 g
Dextrose1,90,14
Lactose0,40,03
Maltose6,70,51
Maltotriose9,50,72
The typical profile of fatty acidsFatty is acid g/100 g
C16:034,6
C16:10,2
C18:04,2
C18:135,8
C18:223,1
C18:31,7
20:10,1
C20:20,3
VitaminsPer 100g powder100 cal*100 ml**
Vitamin aMcg RE
IU
781
2601
110
368
78,1
260
Vitamin DMcg RE
IU
2
7,8
1,4
of 56.4
Vitamin EMcg I.E. α
IU
8,9
13,3
1,3
1,9
0,89
1,3
Vitamin Cmg13419the 13.4
Vitamin Kmcg29,84,23
Thiaminemg0,640,090,06
Riboflavinmg0,850,120,09
Niacinmg81,100,8
Equivalent Niacinmg NE14,82,11,5
Vitamin b6mg0,570,080,06
Folic acidmcg21530,4a 21.5
Vitamin b12mcg1,30,180,13
Biotinmcg16,22,31,6
Pantothenol-th acidmg5,80,820,58
Cholinemg 1702417
Inositolmg1702417
MineralsPer 100 g powder100 kcal*100 ml**
Sodiummg
mmol
318
13,8
45
2
of 31.8
1,4
Potassiummg
mmol
925
23,5
131
3,4
92,5
2,4
Chlorinemg
mmol
547
the 15.6
77,4
2,2
54,7
1,6
Calciummg64991,864,9
Phosphorusmg50070,750
Magnesiummg81,7the 11.68,2
Trace elementsPer 100g powder100 kcal*100 ml**
Ironmg10,71,51,1
Coppermcg 71010071
Zincmgthe 5.70,810,57
Manganesemg0,920,130,09
Iodinemcg12718a 12.7
Molybdenummcgof 31.84,53,2
Seleniummcg192,71,9
Chrome mcgof 31.84,53,2
Fluoridemg0,850,120,09

This composition is obtained by mixing a mixture of palm oil and soybean oil with an aqueous phase comprising the intact milk proteins, maltodextrins, vitamins and minerals and other ingredients, such as flavorings; gomogenizirovannom mixture and spray drying. May not necessarily be included stage heating and cooling, along with additional stages of homogenization. The product includes less than 5 wt.% TRANS fatty acids and shows a very high resistance to oxidation of fat in the education components and flavor.

Example 2: a New formula for babies

The product of Example 1, but modified for specific components.

Component per 100 g powder

Vitamin B6 0.9 mg

Carnitine 50 mg (in the form of acetyl-L-carnitine)

Taurine 60 mg

Pantothenic acid 4 mg

1. Solid or semi-solid nutritional composition comprising protein, lipid and digestible carbohydrates, moreover, the specified components obtained from at least two different sources, providing 2520-3080 kJ per 100 g dry matter, and the weight content of lipids relative to the sum of the contents of protein and digestible carbohydrate is 2.6 to 3.8 to 1.

2. The composition according to claim 1, in which the weight content of the lipid to the sum of the contents of protein and digestible carbohydrate is 2.7 and 3.4 to 1.

3. The composition according to claim 1, in which the lipids include 23-50% wt. palmitic acid to the total weight of fatty acids.

4. Composition according to any one of claims 1 to 3, in which the lipids include 10-25 wt.% one or more phospholipid, lysophospholipid, diacylglyceride and monoglyceride.

5. Composition according to any one of claims 1 to 3, in which the lipids include 16-40% wt. polyunsaturated fatty acids of the total weight of fatty acids.

6. The composition according to claim 5, in which polyunsaturated fatty acids include 1-10 wt.% docosahexaenoic acid.

7. The composition according to claim 1 or 2, in which proteins include 20-80 wt.% α-lactalbumin.

8. The composition according to claim 1 or 2, in which carbohydrates include 20-90 wt.% source of galactose and/or Robotnik units.

9. Composition according to any one of claims 1 to 3, additionally containing from 6 to 100 mg nucleotides per 100 g of dry matter.

10. Composition according to any one of claims 1 to 3, additionally containing more than 25 mg and 200 mg L-carnitine per 100 g of dry matter.

11. Composition according to any one of claims 1 to 3, additionally containing from 40 mg to 1.8 g unsustainable is ivemy oligosaccharides from 3 to 20 monosaccharide units, comprising at least two different monosaccharide units selected from galactose, fructose, fucose, mannose, arabinose, glucuronic acid, galacturonic acid, sialic acid and N-acylglucuronide per 100 g of dry matter.

12. Composition according to any one of claims 1 to 3, in which at least 50 wt.%, preferably at least 75 wt.% on the dry substance is soluble, while getting 10% wt./about. aqueous solution at 20°C.

13. Liquid nutritional product obtained by reduction of a composition according to any one of claims 1 to 11 water.

14. Liquid nutritional product according to item 13, including added vitamins and/or added trace elements and having a caloric content of 1.2-1.8 kcal/ml



 

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1 tbl, 2 ex

FIELD: food industry.

SUBSTANCE: invention can be used for producing a high-quality biologically active supplement applied as preventive food. The biologically active supplement with radioprotective properties represents peeled red rice powder. The powder is produced by way of crushing rice, then it is minced in fine helix-rotating film of 0.1-1.0 mm at pulsing pressure gradient of 10-30 MPa and temperature of 25-30°C.

EFFECT: invention allows to ensure high activity of radioprotective properties by means of a biologically active supplement produced as per the proposed modes.

1 tbl, 3 ex

FIELD: food industry.

SUBSTANCE: invention can be used for producing a high-quality biologically active supplement applied as preventive food. The biologically active supplement with membrane-protective properties represents peeled red rice powder. The powder is produced by way of crushing rice, then it is minced in fine helix-rotating film of 0.1-1.0 mm at pulsing pressure gradient of 10-30 MPa and temperature of 25-30°C.

EFFECT: invention allows to produce a biologically active supplement for food with high activity of membrane-protective properties as per the proposed modes.

1 tbl, 3 ex

FIELD: food industry.

SUBSTANCE: invention can be used for producing a high-quality biologically active supplement applied as preventive food. The biologically active supplement with ergogenic properties represents peeled red rice powder. The powder is produced by way of crushing rice, then it is minced in fine helix-rotating film of 0.1-1.0 mm at pulsing pressure gradient of 10-30 MPa and temperature of 25-30°C.

EFFECT: invention allows to produce a biologically active supplement with high activity of ergogenic properties as per the proposed modes.

1 tbl, 2 ex

FIELD: food industry.

SUBSTANCE: invention can be used for producing a high-quality biologically active supplement applied as preventive food. The biologically active supplement with hypoglycemic properties represents peeled red rice powder. The powder is produced by way of crushing rice, then it is minced in fine helix-rotating film of 0.1-1.0 mm at pulsing pressure gradient of 10-30 MPa and temperature of 25-30°C.

EFFECT: invention allows to produce a biologically active supplement for food with high activity of hypoglycemic properties as per the proposed modes.

1 tbl, 3 ex

FIELD: food industry.

SUBSTANCE: method for production of a biologically active supplement of soya seed coat envisages seed coat separation from soya seeds by way of their maximal dehiscence. For this purpose soya seeds are stepwise treated, for two minutes, with hot water at a temperature of 100°C and undergo showering with cold water at a temperature of 10°C. Then seeds are placed on a sieve with 3 mm size holes; then the sieve is actuated with simultaneous delivery of an air flow thereon at a rate of 3 m/sec. The seed coat separation from soya seeds takes place. The produced soya seed coat is dried in the drying chamber at a temperature of 40°C for 6 hours, ground into 0.5-1.0 mm particles in the electrogrinding machine. The invention allows to produce a biologically active supplement represented by a light yellow fine powder containing wide spectrum of biologically active substances, characterised by adaptogenic and anti-stress effect.

EFFECT: method for production of a biologically active supplement of soya seed coat is affordable and cost-effective because does not require special equipment and high energy costs.

1 tbl, 1 ex

FIELD: food industry.

SUBSTANCE: composition is extruded and represents chewing gum containing: a cellulose component represented by sugar-free inulin -25% - 75% of the said composition weight, a moistener component - 0.001% - 20% of the said composition weight, a carbohydrate component - 5% - 40% of the said composition weight, a fatty component - in an amount of less than 10% of the said composition weight.

EFFECT: composition possesses a pleasant taste, it is a low-caloric and suitable for the consumer, the composition ensures delivery of a high quantity of cellulose to the consumer.

26 cl, 2 tbl, 9 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to hematology and cardiology, and can be sued for reduction of spontaneous erythrocyte aggregation in case of dyslipidemia. For this purpose, at the background of hypolipidemic diet, dosed static and dynamic physical exercise and daily swimming for not less than 30 minutes per day, in the middle of the day simvastatin is introduced. Physical exercise includes morning hygienic gymnastics, therapeutic and preventive gymnastics, dosed physical exercise throughout the day. Simvastatin is introduced in dose 10 mg 1 time per day in the evening after meal. Treatment is carried out for 1.5 months.

EFFECT: method makes it possible to normalise spontaneous erythrocyte aggregation during 1,5 months, bringing its level close to that of healthy people, thus favouring prevention of vascular complications in patients with dyslipidemia.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to hematology and cardiology, and can be used for reduction of spontaneous erythrocyte aggregation in case of arterial hypertension with abdominal obesity. For this purpose at the background of hypocaloric diet, dosed static and dynamic physical exercise and daily swimming for not less than 30 minutes per day in the middle of the day lisinopril and metformin are introduced. Physical exercise includes morning hygienic gymnastics, therapeutic and preventive gymnastics, dosed physical exercised throughout the day. Lisinopril is introduced in dose 10 mg 1 time per day in the morning. Metformin is introduced in dose 500 mg 2 times per day. Treatment is carried out for 2 months.

EFFECT: method makes it possible to normalise spontaneous erythrocyte aggregation during 2 months, bringing it to the level close to that of healthy people, thus favouring prevention of vascular complications in patients with arterial hypertension with abdominal obesity.

2 ex

FIELD: food industry.

SUBSTANCE: inventions group relates to a nutrient composition for preterm infants with very low body weight at birth: with weight equal to 1500 g or less. The composition contains 26-38 g/l of a source of hydrolysed whey protein with 8-20 hydrolysis degree free of allergenic substances, 37-46 g/l of a source of fats, whereof 20-40% are triglycerides with an average length of molecular chain, having a value of n6:n3 ratio 6-12, and 50-100 g/l of a carbohydrates source, the composition containing 3.2-4.0 g of protein per 100 kcal. Application of the source of hydrolysed whey protein with 8-20 hydrolysis degree free of allergenic substances in an amount corresponding to a protein content from 3.2 to 4.0 g of protein per 100 kcal in the process of production of the composition for stimulation of growth with infants with very low body weight at birth with weight equal to 1500 g or less. Application of the source of hydrolysed whey protein with 8-20 hydrolysis degree free of allergenic substances in an amount corresponding to a protein content from 3.2 to 4.0 g of protein per 100 kcal in the process of production of the medical agent for stimulation of growth with infants with very low body weight at birth with weight equal to 1500 g or less.

EFFECT: inventions group allows to stimulate growth of infants with very low body weight at birth.

17 cl, 2 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: present invention refers to medicine, namely to therapy and endocrinology, and can be used for glucose level correction by gluconeogenesis optimisation in a body. That is ensured by introduction of a daily dietary intake with a carbohydrate quota reduced to 150-100 g and the content of glucogenic amino acids increased to 20000-40000 mg 2-3 times a week. Said dietary intake is prescribed after intensive physical exercises allowing to lose 2000-3000 kcal/day. Such loads are carried out in the form accessible to a specific person as jogging, swimming, football, volleyball or work in the garden.

EFFECT: method provides a protein-glucogenic diet stimulating gluconeogenesis enzyme development by a liver.

3 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, particularly to an agent for treating or preventing a peripheral neuropathy. An extract of a family Dioscoreaceae for preventing or treating the peripheral neuropathy recovered by extraction of a of the family Dioscoreaceae with a first extraction solvent selected from the group consisting of water, C1-C4 alcohol and a mixture of water and C1-C4 alcohol. The pharmaceutical composition for preventing or treating the peripheral neuropathy. A food composition for preventing or treating the peripheral neuropathy.

EFFECT: preparations are effective for treating or preventing the peripheral neuropathy.

8 cl, 9 dwg, 1 tbl, 11 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to cardiology and angiologia, and can be used for optimising vascular wall activity in patients with degree I-II arterial hypertension (AH) associating metabolic syndrome (MS) suffered eye vessel thrombosis. That is ensured by introduction of the preparations pioglitazone and amlodipine with underlying an individually prescribed hypocaloric diet and graduated physical exercises. The hypocaloric diet is calculated in kcal by formula: for women of 18-30 years old - (0.0621 × body weight, kg + 2.0357) × 240, of 31-60 years old - (0.342 × body weight, kg + 3.5377) × 240, over 60 years old - (0.0377 × body weight, kg + 2.7545) × 240, for men of 18-30 years old - (0.0630 × body weight, kg + 2.8957) × 240, of 31-60 years old - (0.0484 × body weight, kg + 3.6534) × 240; over 60 years old - (0.0491 × body weight, kg + 2.4587) × 240. The graduated physical exercises represent morning hygienic gymnastics, therapeutic exercises and graduated physical exercises throughout a day. The preparations pioglitazone 30 mg and amlodipine 10 mg are introduced once a day in the same time. The therapy is performed for 4 months.

EFFECT: method provides correction of reduced vascular wall function in the patients with degree I-II AH associating MS suffered eye vessel thrombosis for 4 months and allows avoiding vascular complications in such patients.

1 dwg, 1 tbl, 2 ex

FIELD: food industry.

SUBSTANCE: probiotic oligosaccharides mixture contains 5-70 wt % of at least one N-acetylated oligosaccharide chosen from the group containing GalNAcαl,3Galβ1,4Glc and Galβ1,6GalNAcα1,3Galβ1,4Glc, 20-90 wt.% of at least one neutral oligosaccharide chosen from the group containing Galβ1,6Gal, Galβ1,6Galβ1,4Glc, Galβ1,6Galβ1,6Glc, Galβ1,3Galα1,3Glc, Galβ1,3Galβ1,4Glc, Galβ1,6Galβ1,6Galβ1,4Glc, Galβ1,6Galβ1,3Galβ1,4Glc, Galβ1,3Galβ1,6Galβ1,4Glc and Galβ1,3Galβ1,3Galβ1,4Glc, and 5-50 wt % of at least one sialylated oligosaccharide chosen from the group containing NeuAcα2,3Galβ1,4Glc and NeuAcα2,6Galβ1,4Glc. The food product is represented by a mixture for infant feeding and is characterised by the fact that it contains the said oligosaccharide mixture.

EFFECT: invention ensures predominant effect of the probiotic oligosaccharide mixture on the balance of microbiota, improves state of the host health.

11 cl, 3 dwg, 4 ex

FIELD: food industry.

SUBSTANCE: invention relates to food industry. The method for production of flour confectionary products of preventive purpose involves dough preparation, moulding and baking dough semi-products. For the dough preparation one uses a preventive additive represented by arabinogalactan powder of Siberian and Gmelenii larch wood. The compositions of flour confectionary products of preventive purpose include prime grade bakery wheat flour, melange, sugar sand, treacle, margarine, starch, whole milk, culinary edible salt, carbon-ammonium salt, soda and vegetal raw material. The raw material is represented by the preventive additive i.e. arabinogalactan powder of Siberian and Gmelenii larch wood. The mixture components are taken at the specified ratio.

EFFECT: invention allows to produce products with preventive properties; the products have a high surface colour, a sweeter taste which allows to reduce sugar sand recipe quantity lowering the products calorie content.

4 cl, 6 dwg, 3 tbl, 22 ex

FIELD: medicine.

SUBSTANCE: composition for treating a HIV-infected patient contains eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (ARA), and at least two different oligosaccharides (OL1 and OL2) having monosaccharide unit homology 90 % and lower. In EPA, DHA and ARA, the long-chain polyunsaturated fatty acid content with 20 and 22 carbon atoms does not exceed 85 wt % of total fat content. The offered food composition contains EPA, DHA and ARA, at least two different oligosaccharides having monosaccharide unit homology 90 % and lower, and sour oligosaccharides, preferentially uronic acid polymer of degree of polymerisation 2 to 60. The food composition is also used for making a drug for diarrhoeia treatment or prevention in the HIV-infected patient.

EFFECT: barrier integrity improvement in HIV patients.

11 cl, 7 dwg, 4 tbl, 6 ex

FIELD: food industry.

SUBSTANCE: composition is extruded and represents chewing gum containing: a cellulose component represented by sugar-free inulin -25% - 75% of the said composition weight, a moistener component - 0.001% - 20% of the said composition weight, a carbohydrate component - 5% - 40% of the said composition weight, a fatty component - in an amount of less than 10% of the said composition weight.

EFFECT: composition possesses a pleasant taste, it is a low-caloric and suitable for the consumer, the composition ensures delivery of a high quantity of cellulose to the consumer.

26 cl, 2 tbl, 9 ex

FIELD: food-processing industry, in particular, production of gerodietary food.

SUBSTANCE: method involves preparing and mixing cabbage, tomato, onion, carrot and edible salt; packing resultant mixture; while mixing said components, additionally introducing fermentolysate of fish processing wastes and acidic hydrolisate of fish processing wastes, soya texturizer, flour of bean, sorghum groats, CO2-extract of dill and celery, rape-seed oil, and preparation produced from Mortierella lignicola microorganism biomass by sequential extraction with the use of non-polar extractant in above-critical state, water, alkaline, water, acid, water, alkaline, and water, with following joining of first extract with solid residue. Components are used in dried state and at predetermined ratio.

EFFECT: wider range of gerodietary products.

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