Medication for vaginal application, possessing contraceptive and protective against infectious diseases action

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry and relates in particular to medication for women, which has contraceptive and protective action against inflectional diseases: herpes, HIV infections, viral disease. Medication for vaginal application, possessing contraceptive and protective against inflectional diseases action contains actively-acting components and target base. As actively-acting components medication contains contraceptive, bactericidal, anti-inflammatory preparations, and as target base it contains gel-forming biocompatible polymers and L-lysin hydrochloride with specified component ratio per 1 g. Medication presents gel, ointment, cream, liniment.

EFFECT: medication not only has contraceptive action, but also makes it possible to simultaneously prevent sexually transmitted infection diseases.

3 cl, 6 ex

 

The invention relates to medicine and the pharmaceutical industry, and specifically concerns a medicinal product for women with birth control and protection from infectious diseases action: herpes, HIV, viral diseases.

Widely known drug to women of vegetable origin, which has anti-inflammatory and antiseptic properties.

Famous collection of medicinal herbs "coral" for the treatment of inflammatory female diseases, including camomile, calendula medicinal, the bark of oak, celandine, cottonweed and shepherd's purse. The collection has anti-inflammatory, antimicrobial activity and stimulates the healing of erosions and ulcers. (SU 1836098, AK 35/78, 1992)

Known drug for women, containing needles, with healing, soothing, deodorizing properties. (EN 2040266, AK 35/78, 1992)

Known drug for women douching and hygiene of the genital organs, containing the camomile, the bark of oak, shepherd's purse and nettles. The tool is used as antiseptic, anti-inflammatory agent. (EN 2000801, AK 35/78, 1992)

Known drug for women for the treatment of nonspecific colpitis, dysbacteriosis, etc. the Tool contains faction is Radanovich alcohols, produced by processing wood green conifers, and formative component, which can be used cocoa butter, vaseline oil, beeswax. (EN 2149640, AK 35/78, 2000)

The above drugs for women are not both contraceptive and protection from infectious disease agent.

Solved by the invention the task is to create drugs for women with both contraceptive and protection from infectious diseases effect, due to the symptoms for vaginal introduction of the film-forming properties.

The technical result is to obtain film-forming drugs for women who vaginal application at the same time be protected from the sperm and protect from infectious diseases.

To achieve the technical result remedy for vaginal use with birth control and protection from infectious diseases act, containing active-active components and the target basis, according to the invention as active-active components contains antifertility, antibacterial, anti-inflammatory drugs, and as the target framework contains a gelling b is sovmestimye polymers and L-lysine hydrochloride in the following ratio of components 1 g of product, g:

birth control medicines0,001-0,01
bactericidal drugs0,025-0,02
anti-inflammatory medications0,002-0,01
L-lysine hydrochloride0,001-0,01
gel-forming biocompatible polymersrest

As birth control pills the product contains components selected from the following group: hormones, boric acid, benzalkonium chloride, benzathine chloride, nonoxynol, quinidine.

As bactericidal drugs the product contains components selected from the following group: salts of zinc, nitrate of silver, colloidal silver, dioxidine, boric alcohol, hydrogen peroxide, borowska liquid, broad-spectrum antibiotics, iodopolyvinylpyrrolidone.

As anti-inflammatory drugs the product contains components selected from the following group: diclofenac sodium, indomethacin, ibuprofen, naproxen, corticosteroids: hydrocortisone, fludrocortisone, flumetazon, atamazon, mometazon, perkantoran, triamcinolon.

As g is lebrasse biocompatible polymers tool contains components selected from the group of polyacrylamides, hypromellose, betacyclodextrin.

The drug further comprises a flavoring selected from the group of: tea tree oil, oil of fir, pine oil.

The medicinal product is a gel, ointment, cream, liniment.

The invention is illustrated in the following examples.

Example 1. To obtain funds take:

as the contraceptive pill - boric acid;

as bactericidal drugs zinc salts or silver nitrate;

as anti-inflammatory drugs diclofenac sodium;

as the target framework - hypromellose or betacyclodextrin and L-lysine hydrochloride.

Mix these components in the following ratio in g per 1 g of a mixture of:

/table>

Example 2. To obtain funds take:

as contraceptive drugs and benzalkonium chloride;

as bactericidal drugs - colloidal silver;

as anti-inflammatory drugs indomethacin;

as the target framework is polyacrylamides, or hypromellose and L-lysine hydrochloride.

Mix these components in the following ratio in g per 1 g of a mixture of:

boric acid0,001
zinc salts or silver nitrate0,025
diclofenac sodium0,002
L-lysine hydrochloride0,001
the hypromellose or betacyclodextrinrest
benzalkonium chloride0,01
colloidal silver0,02
indometacin0,01
L-lysine hydrochloride0,01
polyacrylamides or
the hypromelloserest

Example 3. To obtain funds take:

as the contraceptive pill - benzathine chloride;

as bactericidal drugs - dioxidine;

as anti-inflammatory drugs - ibuprofen;

as the target framework - hypromellose and L-lysine hydrochloride.

See who're asked these components in the following ratio in g per 1 g of a mixture of:

benzathine chloride0,001
dioxidine0,025
ibuprofen0,002
L-lysine hydrochloride0,001
the hypromelloserest

Example 4. To obtain funds take:

as the contraceptive pill - nonoxynol;

as bactericidal drugs - boric alcohol or hydrogen peroxide;

as anti-inflammatory drugs naproxen;

as the target framework is polyacrylamides and L-lysine hydrochloride.

Mix these components in the following ratio in g per 1 g of a mixture of:

nonoxynol0,01
boric alcohol or peroxide0,02
naproxen0,01
L-lysine hydrochloride0,01
polyacrylamidesrest

In addition, in the obtained means of introducing the desired amount of tea tree oil.

Example 5. To obtain funds take:

as contraceptive drugs quinidine;

as bactericidal drugs - Borovskoy liquid or antibiotics;

as anti-inflammatory drugs hydrocortisone or fludrocortisone;

as the target framework - hypromellose and L-lysine hydrochloride.

Mix these components in the following ratio in g / g of a mixture of:

quinidine0,001
borowska liquid or antibiotics0,025
hydrocortisone or fludrocortisone0,002
L-lysine hydrochloride0,001
the hypromelloserest

In addition, in the obtained means of introducing the desired quantity of oil fir.

Example 6. To obtain funds take:

as the contraceptive pill - nonoxynol;

as bactericidal drugs - itpriv nerolidol;

as anti-inflammatory drugs betamethasone, or mometazon, or forcertain, or triamcinolon;

as the target framework - betacyclodextrin and L-lysine hydrochloride.

Mix these components in the following ratio in g / g of a mixture of:

nonoxynol0,01
iodopolyvinylpyrrolidone0,02
betamethasone, or mometazon, or forcertain, or triamcinolon;0,01
L-lysine hydrochloride0,01
betacyclodextrinrest

In addition, in the obtained means of introducing the desired quantity of oil of pine.

Received a drug specified in paragraphs 1-6, is a gel or ointment, or cream or liniment and is intended for vaginal administration.

Laboratory testing tool on the model of cell cultures, experimental animals have shown that it is not toxic, has protection from infectious diseases action in full.

Clinical trials conducted on 59 volunteers aged 18-20 years, showed that the drug, designed for vaginal use, has a contraceptive and protective effect against infectious diseases, sexually transmitted diseases such as herpes, HIV infection, viral disease. In addition, it is proved that it is harmless and good move.

Use of the claimed film-forming drugs for women with vaginal application allows you to simultaneously protect against sperm and protect from infectious diseases, sexually transmitted diseases.

1. Medicine for vaginal use with birth control and protection from infectious diseases effect, characterized in that it comprises: contraceptive drugs, selected from the group of boric acid, benzalkonium chloride, benzathine chloride, nonoxynol, quinidine; bactericidal drugs, selected from the group of salts of zinc, nitrate of silver, colloidal silver, dioxidine, boric alcohol, hydrogen peroxide, borowska liquid, broad-spectrum antibiotics, iodopolyvinylpyrrolidone; anti-inflammatory drugs are selected from the group: diclofenac sodium, indomethacin, ibuprofen, naproxen, corticosteroids: hydrocortisone, fludrocortisone, flumetazon atamazon, mometazon, perkantoran, triamcinolon; L-lysine hydrochloride and gelling bio is sovmestimy polymer in the following ratio of components 1 g means:

birth control medicines0,001-0,01
bactericidal drugs0,025-0,02
anti-inflammatory medications0,002-0,01
L-lysine hydrochloride0,001-0,01
gel-forming biocompatible polymerrest

2. The drug according to claim 1, where the biocompatible gel-forming polymer is chosen from the group of polyacrylamides, hypromellose, betacyclodextrin.

3. The drug according to claim 1, may be made in the form of a gel, ointment, cream, liniment.



 

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FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, namely to gynaecology, and can be used for female contraception. Inventions include methods of female contraception. That is ensured by the multiple administration of a dosage form started in a day of month marked either by 'n+3', or 'n+4', or 'n+5', or 'n+6' date and taken out in a day marked by 'n' number of the next month for at least two cycles where 'n' is a date either within 1 to 25, or 1 to 24, or 1 to 23, or 1 to 22 respectively. Also, the inventions involve female contraception kits containing at least two dosage forms and patient information leaflets according to the declared modes of contraception. Besides, the inventions comprise a dosing regimen reminder system adjusted in such a manner that it allows to choose one specific date either within 1 to 25, or within 1 to 24, or within 1 to 23, or within 1 to 22 regardless of a month, as a date when the dosage form is always taken out and a date when a new dosage form shall be used either through three, or through four, or through five, or through six days thereafter respectively.

EFFECT: inventions provide convenient administration of contraceptives with maintained efficacy of contraception and its increase in certain cases.

1 tbl, 9 ex

FIELD: medicine.

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6 cl, 5 dwg, 5 ex

FIELD: medicine.

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11 cl, 4 ex

FIELD: chemistry.

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30 cl, 28 ex, 1 tbl

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91 cl, 6 tbl

FIELD: medicine; pharmacology.

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17 cl, 74 ex

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31 cl, 1 tbl, 9 ex

FIELD: medicine; pharmacology.

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51 cl, 21 dwg, 10 tbl, 4 ex

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3 cl, 2 dwg, 1 ex

Spermicidal agent // 2315602

FIELD: medicine.

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1 tbl

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3 ex

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3 ex

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4 cl, 3 ex

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1 ex

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2 ex

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13 cl, 3 tbl, 36 ex

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3 ex

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4 cl, 32 ex

FIELD: medicine.

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1 tbl, 1 ex

FIELD: medicine.

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2 ex

FIELD: medicine.

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4 ex

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