Method of reducing spontaneous erythrocyte aggregation in case of arterial hypertension with abdominal obesity

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to hematology and cardiology, and can be used for reduction of spontaneous erythrocyte aggregation in case of arterial hypertension with abdominal obesity. For this purpose at the background of hypocaloric diet, dosed static and dynamic physical exercise and daily swimming for not less than 30 minutes per day in the middle of the day lisinopril and metformin are introduced. Physical exercise includes morning hygienic gymnastics, therapeutic and preventive gymnastics, dosed physical exercised throughout the day. Lisinopril is introduced in dose 10 mg 1 time per day in the morning. Metformin is introduced in dose 500 mg 2 times per day. Treatment is carried out for 2 months.

EFFECT: method makes it possible to normalise spontaneous erythrocyte aggregation during 2 months, bringing it to the level close to that of healthy people, thus favouring prevention of vascular complications in patients with arterial hypertension with abdominal obesity.

2 ex

 

The invention relates to medicine, namely to Hematology and cardiology.

Analogues of the proposed method of reducing the spontaneous aggregation of erythrocytes (SAE) in patients with arterial hypertension (AH) with abdominal obesity (AO) does not exist.

For the correction of arterial hypertension is often prescribed ACE inhibitors, including lisinopril, to reduce the extent of JSC applies a low-calorie diet and Metformin, in the correction pattern of patients with hypertension with AO, often includes physical exercise and swimming.

In preparing this proposal was tasked to develop an effective and affordable way to reduce aggregation of erythrocytes in patients with AO, which would solve the problem of correction of AG and JSC with a simultaneous normalization of SAE and thereby prevention in a wide range of patients with hypertension with JSC development of myocardial infarction, cerebral stroke and thrombosis of different localization.

When ever medical complex, consisting of a low-calorie diet, individually tailored physical training, swimming and drugs lisinopril and Metformin has been used in patients with AO to normalize SAE.

The aim of the invention is to increase the efficiency of correction of violations SAE in patients with AO.

The essence of the proposed method lies in the fact that for the correction With the e sick AG with AO long is assigned a complex of low-calorie diet, dosed physical exercise, daily swimming for at least 30 min a day in the middle of the day and drugs lisinopril at a dose of 10 mg 1 time a day, morning and Metformin 500 mg 2 times a day.

The method allows to correct SAE in patients with AO for 2 months, translating it to a level close to that of healthy people. Subject to the subsequent recommendations of the proposed method can be maintained SAE, and therefore, the rheology of blood in an optimal state, which will significantly reduce the risk of thrombotic complications, reduce the number of cases of temporary disability, to accelerate and improve the quality of patient treatment, reduce disability, and also to prolong the life and reduce mortality of patients with arterial hypertension with AO from a heart attack, stroke and thrombosis of different localization.

The inventive method is carried out as follows. Taking 9 ml of blood is produced in the morning after a 14-hour fast from Vienna through the thick needle by gravity into a test tube with sodium citrate in the ratio of 9:1 to assess the aggregation of erythrocytes.

Erythrocyte aggregation is assessed by the degree of ability of erythrocytes to spontaneously aggregate (Pokrova O.A., Grineva MR, Ivanov K.S. Methodology and clinical significance of the study the rheological properties of blood. // The Bulletin of the Ivanovo medical Academy. - 2008. - T13, No. 1-2, - s.89-98.)./p>

To assess the aggregation of erythrocytes blood from a vein taken in sodium citrate in the ratio of 9:1 and centrifuged 10 min at 3000 rpm/min In 96-well pad fill 2 holes 0.2 ml plasma of the subject. From the tube removed all the plasma and the layer of leukocytes. Erythrocytes resuspendiruetsa standard phosphate buffer in the ratio 1:4, followed by centrifugation for 10 min at 3000 rpm, allowing you to wash them from the remnants of the plasma when removing the supernatant. After this is taken as 0.02 ml of erythrocytes and resuspended first filled with autologous plasma-well 96-well Ouija boards, allowing you to get 10% hematocrit. Then from this hole, take a clean, dry pipette 0,02 ml content and placed in the second filled the hole that allows you to get 1% hematocrit. After that 1 grid in the camera Goryaeva fill obtained a suspension of red blood cells, incubated 3 min for the occurrence of spontaneous aggregation and shall count free erythrocytes (including 2 of the erythrocyte together) and units, starting with 3 cells, connected in the form of "monetary columns") in 2 large squares of the camera (lens ×40, eyepiece ×10). Considered the number of "coin of columns and the number of red blood cells, involved in them.

Based on these results, calculate the following indicators that assess SAE:

1) Average the size of the unit (CPA):

CPA=sea/KA;

Sea - the sum of all cells in the units;

KA - the number of units.

2) the Index of aggregation (PA):

PA=(CPA·KA+CTU)/(KA+CTU)

CTU - free erythrocytes.

3) the Percentage of non-aggregated RBCs (PNA):

PNA=CSE·100/(CPA·KA+CSP).

Normative values for CPA are 4-5, PA 1,05-1,30, for the PNA 80,0-92,0%. The increase in CPA above 5, and PA above 1.30 and lowering the PNA below 80,0% talks about increasing the SAE. In case of violation of at least one of these three indicators of sick AG with JSC must be treated according to the claimed method.

To create a negative energy balance in the body, patients are advised individually selected low-calorie diet.

Calorie daily diet individually for each patient with MS is calculated in kcal by the formula:

for women 18-30 years (0,0621 × body weight (kg) + 2,0357)×240,

31 - 60 years (0,0342 × body weight (kg) + 3,5377)×240,

over 60 years of age (0,0377 × body weight (kg) + 2,7545)×240,

for men 18-30 years (0,0630 × body weight (kg) + 2,8957)×240,

31 - 60 years (0,0484 × body weight (kg) + 3,6534)×240,

over 60 years of age (0,0491 × body weight (kg) + 2,4587)×240.

The resulting coefficient remains unchanged with minimal physical activity, multiplied by 1.3 in moderate and 1.5 - high physical activity (usually in patients level of physical the banking activity is low).

It is recommended that 3 main meals and 2 intermediate. With regular skipping one meal significantly increases the incidence of obesity, also revealed a positive correlation between obesity and skipping Breakfast. It is recommended that the following distribution of daily calories: Breakfast - 25%, 2nd Breakfast - 10%, lunch - 35%, tea - 10%, dinner - 20%.

To compile menu the patient uses a special table with the instructions of the chemical composition and caloric content of products, given that the main sources of energy: protein (1 g contains 4 kcal), fat (9 kcal), carbohydrates (4 kcal) and alcohol (7 kcal).

The second component of the proposed method is feasible regular physical exercise.

In real life you can implement the three forms of physical activity: 1) morning hygienic gymnastics (charging); 2) health care gymnastics; 3) fractional exercise during the day.

1. Morning hygienic gymnastics (charging)

Morning gymnastics should do after waking up to Breakfast in a ventilated room. Under the influence of training the body is released from the state of inhibition of the physiological processes taking place during sleep.

The sequence of the exercises involves the alternation of load on different mysen the e group (hands, legs and body). Exercises are performed with gradually increasing excursion breathing, stretching, limited use of power conditions. Breathing exercise should be free, rhythmic, without delay, mainly through the nose; the exhalation should be longer than the inhale (breath in 2-3 sec, exhale 3-5).

In good health the load, you can increase the number of repetitions faster, increase range of motion and shorter pauses between exercises.

When fatigue should reduce the load, increase the duration of pauses between exercises, to fill their quiet breathing.

After gymnastics, you must go to the rubbing or take a shower.

Morning exercises should evoke a sense of vitality, increased activity, improved health and performance.

If you feel unwell, develop shortness of breath or pain in the heart and behind the sternum should be temporarily suspend classes and consult a doctor.

During the day, sick AG with JSC recommended treatment and preventive exercises. Depending on the initial fitness may apply at the beginning of the lightweight option, physical activity, and subsequently enhanced option.

2. Complexes of preventive and curative gymnastics for persons suffering from hypertension and AO.

2.1. A lightweight version of the medical-profilactics the first gymnastics

Exercise 1. Standing. A quiet walk with a gradual acceleration and deceleration 1-2 minutes on the exercise of the gradual deepening of the breath.

Exercise 2. Circular motion in the shoulder joints. When breeding - breath, when the note - exhale with a slight tilt of the torso and retraction of the abdominal wall 6-8 times. The fingers touch the shoulders, elbows close to the torso.

Exercise 3. Standing, hands on his belt. Alternately shifting the weight of the body from one foot to the other with a small bending the legs at the knee joint without lifting the feet from the floor. Exercise done 10-16 times with the muscles of the legs.

Exercise 4. Standing, feet apart at shoulder width, hands on his belt. Bending the trunk forward, touch right hand to left toe. 4-6 times alternately. When straightened position - breath, when the tilt - exhale. To look ahead.

Exercise 5. Standing with arms along the body. At the same time to take straight arm and one leg to the side with alternating lead leg. 4-6 times in each direction in turn. A wave of the hands and feet, breathe freely, do not delay.

Exercise 6. Standing, feet apart, hands in front of chest with palms down. With a turn of the body to dissolve hand in hand with turning the palms up - breath. To return to the original position with a small tilting forward, exhale. 3-5 times in each direction in turn. Breath to agree with the movement to the receiving corps and hands. By the end of exhalation to engage the wall of the abdomen.

Exercise 7. Standing, hands free. The walk free - 1 min, then with high flexion of the hips - 10-20 movements with subsequent transition to a peaceful walk 1-2 minutes Breathing rhythmic, medium depth.

Exercise 8. Sitting on the edge of the chair, hands on the waist. The bowing of the back and bending forward of the body. Repeat 6-10 times. Breathing is not to delay.

Exercise 9. Sitting on the edge of the chair, the emphasis tassels on the edge of a chair, and your feet slightly in front of the chair. Squats with a focus hands on the edge of a chair - 4-6 times. When you squat exhale.

Exercise 10. Standing sideways to the back of the chair to hold it with one hand. Swing free straight arm with leg pulling back. To return to the original position. Repeat 4-6 times for each leg and arm. Breathing is not to delay.

Exercise 11. Standing, legs apart widely, hands on waist. Turns the body right and left - 6-10 times alternately. The head does not turn, to look forward.

Exercise 12. Standing, feet together, hands down. Move the hands to the sides, inhale, bend the leg at the knee and pressed his hands to his stomach exhale. 3-5 times each leg alternately. Strive to maintain balance; on the exhale, draw your abdomen.

Exercise 13. Standing, feet together, hands down. The side slopes of the case with flexion of the opposite hand ("pump"). Breathing is not to delay, to strive for greater is excursie movement.

Exercise 14. Standing. A quiet walk with a uniform average depth of breathing. 1-2 minutes

Exercise 15. Lying on the Mat to put under your head with a pillow. Go to a half-sitting position and bent to hug the hips, exhale, return to the starting position and inhale. Breath hold. Strive in a semi-sitting position to maintain balance. Run 4-6 times.

Exercise 16. Lying down, arms at sides, legs apart. A semi-circular motion right straight leg to the left with the rotation of the pelvis - exhale, return to the starting position and inhale. 3-5 times in each direction. Alternately left and right, with the greatest possible excursion movement of the leg, keeping the emphasis brushes the floor.

Exercise 17. Sitting on the floor; a) to stand on all fours; b) to move into position on his knees; hands up - breath, torso, and hands to take back - exhale. When the tilt pull the stomach. Repeat 4-6 times; d) to go into a standing position, and son-in-law in the supine position; (e) self-massage of the abdomen small polukrugom movements clockwise - 1-2 minutes Rest 2 min; W) quiet breathing; C) exercise the protrusion (calm) and retraction (active) abdominal wall. The retraction of the abdomen combined with exhale through the mouth. Repeat 4-6 times.

Exercise 18. Standing with arms bent. Energetic walking on the spot or area of high flexion of the hips and waving of hands - 20-30 step the century Breathing is not to delay.

Exercise 19. Sitting on a chair, legs apart, hands on the waist or rest against the edge of a chair. The circular motion of the pelvis with the retraction of the abdomen when moving the pelvis back. 4-6 times in each direction.

Exercise 20. Standing. A peaceful walk with the breath of the average depth of 2-3 minutes

When the source sufficient trained or arising in the course of the practice of tolerance to physical loads you can use the following set of exercises.

2.2. Enhanced preventive and curative gymnastics

Exercise 1. Standing. The quiet walk with rubbing the palms of the thorax, abdomen, lower back. Runs 1-2 minutes

Exercise 2. Standing, hands down. Simultaneous bending with tension and free "throwing" hand forward, sideways and upwards of 12-16 times. When you bend exhale, when the alignment of breath.

Exercise 3. Standing, hands on waist, legs shoulder-width apart. Lateral motion of the pelvis to the right and left, back and forth. Is 6-10 times alternately. Breathe freely.

Exercise 4. Standing, feet shoulder-width apart, hands down. Circular motion direct hand in the shoulder joints, 6-10 times with a maximum excursion, breathing, do not delay.

Exercise 5. Standing, hands in front of chest, bent at the elbows. Walking with high flexion of the hips, with a touch of the hand. 6 to 10 times for each leg alternately. Motion is energetic, when hip flexion - exhale through the mouth.

Exercise 6. The quiet walk 1-2 minutes

Exercise 7. Sitting on the edge of the chair, hands on the waist. Bending and bowing of the body. The exercise is performed 8-10 times. The energetic movement. When straightening - breath, bending exhale.

Exercise 8. Standing sideways to the chair, to hold back, the other hand on the waist. Alternate sweeps straight leg forward, with the greatest possible tour. Swing legs to be combined with the exhalation. Runs 4-6 times.

Exercise 9. Standing, feet apart, hands at sides. Bending the body forward, touch right brush left toe of the feet, the other hand is allotted up. To return to the original position. Tilt combined with exhalation, by straightening the breath by 4-6 times.

Exercise 10. Walking the quiet breathing of medium depth. 1-2 minutes

Exercise 11. Standing, hands in a fist and lowered: (a) bending of the arms at the elbows with the power and flattening them with the lead back with possibly a large rectification and voltage and delay in the stress state within 2-3 C. Standing, hands on waist; b) proprietary with subsequent lifting in socks and tension legs. The exercise is performed 4-6 times with possibly large rectification and voltage and delay in the stress state within 2-3 C.

Exercise 12. Sitting on the edge of the chair. In the raised position and bent knee leg done is manage alternately shaking hands, leg muscles and hips. To reduce muscle tension. 1-2 minutes

Exercise 13. Sitting on the edge of the chair, straight leg divorced. Pinch open and direct the hands and feet. When breeding breath, when the note - exhale. Is 4-8 times.

Exercise 14. Standing. The quiet walk with the transition to the rhythmic quiet running (Jogging) on the spot or moving. For fatigue to go on a peaceful walk with the breath of medium depth. 2-5 minutes

Exercise 15. Lying on the Mat. Simultaneous lifting of the body and legs on the exhale. 4-6 times. Arms and legs should be straight, to keep the balance.

Exercise 16. Lying on the Mat, the emphasis brushes the floor. Cross movement straight leg - scissors. 4-8 times. Breathing is not to delay.

Exercise 17. With a quick straightening of the legs to move into a sitting position, then to lie down. You can help stroke 4-6 times.

Exercise 18. Lying on your back, legs bent. Calm breathing 4-6 times.

Exercise 19. Lying on his back, hands diluted with emphasis brushes the floor. With the rotation of the pelvis to the left to bend the legs, rotate the pelvis with legs crossed to the right and stretch the legs. To repeat such a circular motion feet 3-6 times in each direction alternately. Hands not off the floor. Breathing is not to delay.

Exercise 20. Lying on your back, arms and legs separated. Alternate turns the body right and left laying one hand to the other. Nogis place to shift. When divorced hands - breath, turning exhale. Performed 3-6 times.

Exercise 21. Lying on your back, arms along the body: a) turn on your left side; b) to turn on the right side; C) switch to lying on his stomach; to kneel; d) to move in a standing position; (e) walking on the spot with high flexion of the hips and the movement of the hand - 20-30 steps; g) to sit on the Mat; C) lie on your back, relaxing breath. The whole complex repeat 3-4 times.

Exercise 22. Standing. Walking the quiet breathing of the average depth of 1-2 minutes

Exercise 23. Standing, feet apart on the width of the foot, hands on waist. Circular motion of the pelvis to the right and left 6-8 times. Breathing is not to delay.

Exercise 24. Standing with legs wide apart, hands in front of chest. Alternately bending the legs with the transfer to it of gravity of the body with stretching hand to toe of the bent leg. 4-6 times in each direction. The other leg is straight. When straightening - breath, when the tilt - exhale.

Exercise 25. Standing, feet apart at shoulder width, hands on waist. Circular head movements by 4-10 times in each direction.

Exercise 26. Standing, feet apart at shoulder width, hands on waist. Bend trunk to the right, pulling the left arm up - breath. Return to starting position - exhale. 4-6 times alternately.

Exercise 27. The same hands to the shoulders. Circular motion of the brush with a maximum excursion in PL the individual joints, when breeding - breath during the mixing and retraction of the abdominal wall exhale. Breathing deep.

Exercise 28. Standing. A peaceful walk and breath the average depth. The reduction of the total load. 1-2 minutes

3. Fractional exercise during the day.

Depending on the conditions of real life in patients with hypertension with AO can recommend various exemplary embodiments of the fractional loads to increase physical (motor) activity during the day.

Option 1

Exercise 1. Sitting - dilute the elbows to the sides, inhale, extend hands forward voltage exhale, 4-6 times.

Exercise 2. Sit - to stand with the deflection of the housing and land - 8-10 times.

Exercise 3. Sitting mimicking the movements of a boxer with possibly a large turn of the body is 10-12 times.

Option 2

Exercise 1. Standing - walking with high flexion in the hip-16-30 times.

Exercise 2. Standing - circular head movements to the right and left - 3-8 times in each direction.

Exercise 3. Standing legs apart widely imitated the movements of Costa - 10-12 times.

Exercise 4. Sitting - transition into the standing - 10-12 times.

Option 3

Exercise 1. The quiet walk - 1 min

Exercise 2. Walking fast - 1 minute

Exercise 3. Walking with high flexion of the hips and alternate wave of the hands 20-30 times.

Exercise 4. Walking the quiet breathing of 1-2 min; quiet running on the spot or p is ramieniem on the premises - 2-5 minutes

Option 4

Walk the pedestrian varying length.

Option 5

Physical work in different ways and with different duration depending on the conditions (cleaning, home services, cleaning, gardening work, and others).

The third component of the claimed method is a daily swim in the sea, the river or the pool for at least 30 minutes a day in the middle of the day.

The fourth component of way of leveling advanced SAE in patients with AO is the appointment of lisinopril at a dose of 10 mg 1 time a day, morning and Metformin 500 mg 2 times a day.

Example 1. Patient N., for 43 years, suffering AG with the company for 8 years, were examined during the follow up inspection regarding arterial hypertension. The patient was taken to the blood in a plastic tube with subsequent study of the aggregation activity of erythrocytes (CPA=5,6, PA=1,65, PNA=67,5%), indicating that the increase of the AOC.

The patient was recommended a low-calorie diet, exercise load, swimming in the pool at least 30 minutes a day in the middle of the day, the reception of lisinopril 10 mg in the morning and Metformin 500 mg 2 times a day.

After 1.5 months found that the patient SAE (CPA=4,1, PA=1,09, PNA=80,9%) is normalized.

Example 2. Patient Y., 54 years old, suffering AG with the company for 10 years, screened during ispensing inspection regarding arterial hypertension. The patient was taken to the blood in a plastic tube with subsequent study of the aggregation activity of erythrocytes (CPA=6,2, PA=1,80, PNA=44,4%), indicating a sharp increase in the SAE and the risk of thrombosis.

The patient was recommended a low-calorie diet, measured static and dynamic exercise, daily swimming for at least 30 min a day in the middle of the day, lisinopril 10 mg in the morning and Metformin 500 mg 2 times a day.

After 2 months of treatment indicators aggregation of erythrocytes (CPA=4,5, PA=1,25, PNA=86.2 per cent) is normalized, indicating a normalization of the AOC of the patient.

The use of the proposed correction method SAE in Hematology and cardiology will help to avoid many of vascular complications in patients with AO, to reduce their number of cases of temporary disability, to reduce the duration of hospitalization, reduce morbidity and mortality.

The way to reduce the spontaneous aggregation of red blood cells in arterial hypertension abdominal obesity, comprising applying a low-calorie diet, measured static and dynamic physical loads, which includes morning hygienic gymnastics, therapeutic gymnastics, fractional exercise during the day, a daily swim at least 30 minutes a day in the middle of the day, the reception of lisinopril in the Oze 10 mg 1 time a day, morning and Metformin 500 mg 2 times a day for 2 months.



 

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42 cl, 2 dwg, 4 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to cardiology and angiology, and deals with correction of functions of vascular walls in patients with arterial hypertension of I-II degree with metabolic syndrome, after thrombosis of eye vessels. For this purpose indices of anti-aggregate, anti-coagulant and fibrinolytic activity of vascular wall are determined. On the basis of said indices calculated is total anti-thrombotic potential of vessels and if its value is 0.069 and lower, complex treatment, including application of individually selected hypocaloric diet, dosed physical load, pioglitazone 30 mg 1 time per day and valsartan 160 mg 1 time per day in the morning during 4 months, is administered.

EFFECT: complex of drug and non-drug therapy in combination with empirically selected duration of treatment ensures correction of functions of vascular wall and, thus, reduction, of risk of thrombotic complications in said group of patients due to potentiation of therapeutic effect of separate components of therapeutic complex.

1 ex, 1 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to bis[3-(4-chlorophenyl)-1-(4-methylphenyl)carboxamido-1,3-propanedionato]oxovanadium of formula: . The compound has hypoglycemic and antihypoxic activity.

EFFECT: obtaining a compound having high hypoglycaemic and antihypoxic activity and low toxicity.

1 ex, 2 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology and endocrinology, and can be used for decreasing spontaneous erythrocyte aggregation in impaired glucose tolerance. That is ensured by introduction of metformin with underlying graduated static and dynamic physical exercises and daily swimming for at least 40 minutes a day in the middle of day. Physical exercises include morning hygienic gymnastics, therapeutic exercises, graduated physical exercises during the day. Metformin 500 mg is introduced 2 times a day. The therapy is carries out for 1.5 months.

EFFECT: method allows normalising spontaneous erythrocyte aggregation for 1,5 months, approaching a level close to such in healthy people, thereby promoting prevention of vascular complications in patients with impaired glucose tolerance.

2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to an ester presented by formula [2] where R1' represents 1) C1-C6 alkyl which is optionally substituted by one or more identical or different halogens, or 2) -CO-C1-C6 alkoxy; R2' represents 1) hydrogen or 2) C1-C6 alkyl, R3', R4' and R5' are identical or different, and each represents 1) hydrogen, 2) halogen, 3) C1-C6 alkyl which is optionally substituted by one or more identical or different halogens, 4) C1-C6 alkoxy, 5) -COR13' where R13' represents (a) hydroxy, (b) C1-C6 alkyl, (c) C1-C6 alkoxy which is optionally substituted by one or more identical or different substitutes selected from (1) hydroxy, (2) C1-C6 alkoxy which is optionally substituted by phenyl, (3) -NR11'CO-C1-C6 alkyl where R11' represents hydrogen, (4) -CONR8'R9' where R8' and R9' are identical or different, and each represents C1-C6 alkyl, (5) -CO- C1-C6 alkoxy optionally substituted by phenyl, (6) phenyl optionally substituted by one or more identical or different substitutes selected from halogen, C1-C6 alkoxy and -CO-C1-C6 alkoxy, and (7) a heterocycle selected from pyridyl, thienyl and which all can be substituted by one or more identical or different C1-C6 alkyl groups, or (d) -OR19' where R19' represents a group or a group or piperidyl which is optionally substituted by -CO-C1-C6alkyl, 6) a heterocycle selected from oxadiazolyl and tetrazolyl, and said heterocycle is optionally substituted by C1-C6 alkyl optionally substituted by one or more identical or different substitutes selected from -CONR8'R9' (R8' and R9' have the same values as defined above) and -CO-aralkyloxy, or 7) nitrile; R6' and R7' are identical or different, and each represents 1) C1-C6 alkyl or 2) a nitrogen-containing 5 or 6-members saturated heterocycle containing a monocycle formed when R6', R7' and a neighbouring nitrogen atom are taken together, and optionally including oxygen as a heteroatom; Y1, Y2, Y3 are identical or different, and represent, 1) all carbon atoms, or 2) one of Y1, Y2, Y3 represent a nitrogen atom, and the others are carbon atoms; Y4 represent a carbon or nitrogen atom ;-X- represents 1) -(CH2)1 where 1 represents an integer 1 to 3, 2) -CH2-NR18'-CH2- where R18' represents C1-C6 alkyl, or 3) or to its pharmaceutically acceptable salt.

EFFECT: compounds presented by formula are effective as agents for treatment or prevention hyperlipidemia, arteriosclerosis, coronary artery disease, obesity, diabetes and hypertension or similar diseases since they are withdrawn very quickly and exhibit excellent MTP inhibitory activity.

23 cl, 32 tbl, 137 ex

FIELD: medicine.

SUBSTANCE: present invention refers to medicine, namely to therapy and endocrinology, and can be used for glucose level correction by gluconeogenesis optimisation in a body. That is ensured by introduction of a daily dietary intake with a carbohydrate quota reduced to 150-100 g and the content of glucogenic amino acids increased to 20000-40000 mg 2-3 times a week. Said dietary intake is prescribed after intensive physical exercises allowing to lose 2000-3000 kcal/day. Such loads are carried out in the form accessible to a specific person as jogging, swimming, football, volleyball or work in the garden.

EFFECT: method provides a protein-glucogenic diet stimulating gluconeogenesis enzyme development by a liver.

3 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention aims at improving pharmacological activity of an antidiabetic composition. Said technical effect is ensured by the fact that there is offered a polypharmaceutical herbal tea which contains herbs comprising vitamins and digestible sugars and metabolism-regulation plants. The tea contains: goat's rue (Galega) herb, European walnut leaf, knotgrass herb, dense mullein blossom, dandelion root, tillet blossom, white mulberry leaf, horseheal root, cowberry leaf, bean valves, common periwinkle leaf, common argimony herb in various proportions. The offered composition can be presented in the form of phyto tea in filter bags 2.0 g.

EFFECT: administration of said preparation allows reducing doses of antidiabetic preparations.

2 ex, 3 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to cardiology and angiologia, and can be used for optimising vascular wall activity in patients with degree I-II arterial hypertension (AH) associating metabolic syndrome (MS) suffered eye vessel thrombosis. That is ensured by introduction of the preparations pioglitazone and amlodipine with underlying an individually prescribed hypocaloric diet and graduated physical exercises. The hypocaloric diet is calculated in kcal by formula: for women of 18-30 years old - (0.0621 × body weight, kg + 2.0357) × 240, of 31-60 years old - (0.342 × body weight, kg + 3.5377) × 240, over 60 years old - (0.0377 × body weight, kg + 2.7545) × 240, for men of 18-30 years old - (0.0630 × body weight, kg + 2.8957) × 240, of 31-60 years old - (0.0484 × body weight, kg + 3.6534) × 240; over 60 years old - (0.0491 × body weight, kg + 2.4587) × 240. The graduated physical exercises represent morning hygienic gymnastics, therapeutic exercises and graduated physical exercises throughout a day. The preparations pioglitazone 30 mg and amlodipine 10 mg are introduced once a day in the same time. The therapy is performed for 4 months.

EFFECT: method provides correction of reduced vascular wall function in the patients with degree I-II AH associating MS suffered eye vessel thrombosis for 4 months and allows avoiding vascular complications in such patients.

1 dwg, 1 tbl, 2 ex

FIELD: veterinary science.

SUBSTANCE: invention refers to a composition including alginate containing high concentration of mannuronic acid and a polycation of a polydispersity index less than 1.5. The composition is especially suitable for manufacturing of biologically compatible microcapsules containing live cells for allo- or xenografting.

EFFECT: microcapsules are more durable and can keep their structural and functional integrity for a long period of time as compared with common alginate microcapsules.

57 cl, 2 ex, 6 tbl

FIELD: medicine.

SUBSTANCE: invention relates to complex immunomodelling treatment of patients with chronic heart failure (CHF). For this purpose to patients with CHF of II-IV functional classes according to NYHA and LV ejection fraction less than 45% at the background of conventional complex therapy, which includes application of diuretics, vasodilatators, cardiac glycosides, inhibitors of angiotensin-converting enzyme, additionally introduced is carvedilol in dose 12.5-50 mg/day. Introduction is performed in two intakes in equal parts for 12 months.

EFFECT: reduction of cytokine activity and syndrome correction of secondary immunodeficiency, which reduces severity of tissue affection and improves microcirculation and central hemodynamics, reduction of CHF severity and prevention of heart remodeling in said group of patients.

2 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: invention represents application of composition, which includes protein material, where said protein material provides, at least, 24% of energy value of composition (en.%) and, at least, 12 wt % of all protein material is represented by leucine, for preparation of medication for treatment of subject with obesity.

EFFECT: extension of assortment of compositions, efficient for treatment of obesity.

35 cl

FIELD: medicine.

SUBSTANCE: claimed are method of reducing in circulating blood of LDL-cholesterol, triglycerides, total cholesterol and their mixtures, including introduction of efficient amount of one or more phosphate derivatives of one or more electron-transfer agents, which represent monotocopheryl phosphate, dotocopheryl phosphate, monotocotrienyl phosphate, ditocotrienyl phosphate and their mixtures, their application for relief of symptoms, treatment and/or prevention of disease, selected from group which consists of chronic renal failure, primary and secondary hyperemias and dislipemia, retinopathy, enlargement of liver and spleen, xanthomas and their combinations by reduction of lipid content in circulating blood.

EFFECT: reduction under action of claimed tocopherylphosphates of levels of total cholesterol, LDL in mice and reduction in them of atherosclerotic lesions, in people - improvement of dislipidemia state and increase of HDL cholesterol in comparison with tocopherol acetate.

5 cl, 3 dwg, 5 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to psychiatry, and can be used in therapeutic regimens of schizophrenic patients. A method for correction of negative schizophrenia symptoms in patients with comorbide arterial hypertension consists in the fact that psychotropic drugs are combined with lisinopril 10 mg/day twice; if observing no blood pressure decrease 140/90 mm Hg and lower, lisinopril is added with a preparation amlodipine 10 mg/day twice; lisinopril and combined lisinopril and amlodipine are prescribed for undefinitely protracted periods, but not less than for 6 months.

EFFECT: invention provides reliable decrease in manifestation of the negative schizophrenia symptoms.

1 tbl

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