Method of laboratory diagnostics of early disorders of liver functional state
SUBSTANCE: invention relates to field of medicine. For laboratory diagnostics of early disorders of liver functional state activity of ALT, AST, LDH, GGT, ALP, total bilirubin are measured. Additionally carried out is 3-minute long occlusion of shoulder vessels - "cuff test" (CT) to create short-timer hypoxia. Indices of liver functional activity are determined by the following formulas: ALT index=((ALT after CT - ALT before CT)/ALT before CT)*100%; AST index=((AST after CT - AST before CT/AST before CT)*100%; LDH tot = ((LDH after CT - LDH before CT)/LDH before CT)*100%; ALP index=((ALP after CT - ALP before CT)/ALP before CT)*100%; GGT index=((GGT after CT - GGT before CT)GGT before CT)*100%; Bilirubin index=((Bilirubin after CT - Bilirubin before CT)/Bilirubin before CT)*100%. If said indices increase by more than 10%, early disorder of liver functional state is diagnosed.
EFFECT: method increases diagnostics efficiency due to early detection of liver functional state disorders, preceding registered by laboratory methods changes in its functioning.
2 ex, 4 tbl
The invention relates to medicine, namely to methods of determining violations of the functional state of the liver.
There is a method of use of the "cuff" of the sample (MP) to assess atrombogennoe endothelial function and hematopathology interactions (Method of Balady MV), based on short-term occlusion of vessels shoulder overlay cuff sphygomanometer. In the body of information about the response of cells of various organs and tissues to any changes in living conditions is passed through various blood components and using the cells of the vascular wall. When this tissue cells "respond" release of certain biochemical substances depending on their functional state. The thrust of these changes is determined and at short-term change in living conditions (such as short-term ischemia or hypoxia - in this case, MP).
It is known that under the influence of intermittent hypoxia occurs metabolic response, which is not only in the physiological reactions of the organism, but also in a change of biochemical parameters of blood (Tkachuk E.N., Lyapkov astray freight, Tsvetkova A.M. "Metabolic response to short-term hypoxia in young, healthy volunteers" // Hyp. Med. J. 1994. Vol.2. # 4. C). Closest to the invention is the manual evaluation of the functional state of the liver in patients with chronic hepatitis and cirrhosis of the liver" (D2: EN 2194280 C2 from 10.12.2002,), in which considered hypoxia as a test stimulus of hemostasis", to confirm the degree of decompensation processes in the liver, when it is already known clinical and laboratory violation of its functioning (cirrhosis and hepatitis).
On the other hand, closest to the invention is an accepted method for laboratory diagnosis of disorders of the functional state of the liver by measuring the activity of the enzymes ALT, AST, LDH, GGT, alkaline phosphatase, and total bilirubin (Ayacuchano, Viewcom, VOB, WAV, Yevgani. The textbook "Clinical Biochemistry", publishing house "Fact" of 2005 and other textbooks on the wedge. Biochemistry).
However, this method finds a violation of the functional state of the liver only when it is determined a significant increase of these parameters in the blood.
The authors of the present invention found that the use MP for early diagnosis of functional disorders of the liver. Was first used MP not only as a functional assay for the study of endothelial function and as a test stimulus of hemostasis", but also to create short-term hypoxia, under the influence of which is metabolic response, i.e. the change of a number of biochemical parameters of blood (ALT, AST, LDH, GGT, alkaline phosphatase, total bilirubin, reflecting/characterizing (donnaslut) the functional state of the liver.
The technical result of the invention is to improve the efficiency of diagnosis through early detection of violations of the functional state of the liver, previous laboratory registered the change of its functioning (i.e. increase of the indicators listed above), as well as clinical manifestations of disturbances. This allows you to start timely and adequate medical prevention, aimed at restoring the normal functioning of the liver.
The method consists in the following.
Perform quantitative evaluation of the activity of liver enzymes ALT, AST, total LDH, alkaline phosphatase, GGT, and bilirubin before and after MT. MP - three-minute occlusion of the vessels of the shoulder caused by the imposition of the cuff of sphygomanometer on the shoulder of the subject. Determine the indices of functional activity, which shows the relationship of these indicators before and after MT. The indexes are calculated by the following formulas:
Index ALT = ((ALT after MP - ALT to MP)/ALT to MP)·100%.
Index ACT = ((ACT after MP - ACT to MP)/AST to MP)·100%.
The index of total LDH = ((LDH after MP - LDH to MP)/LDH to MP)·100%.
The alkaline phosphatase index = ((alkaline phosphatase after MP - alkaline phosphatase to MP)/alkaline phosphatase to MP)·100%.
Index GGT = ((HPT after MP - GGT to MP)/GGT to MP)·100%.
Index Bellyrub. = ((Bilirubin after MP - Bilirubin up to MP)/Bilirubin up to MP)·100%.
So conduct a quantitative assessment of the degree above the FL-defined indicators. In normal (healthy individuals) indices do not exceed 5%. Indices of six parameters compared with the same indices in healthy persons. When it detects an increase of more than 10% of diagnosed disorders of the functional state of the liver.
The rate of change of indicators does not occur or does not exceed 5%. It was investigated and evaluated in 44 healthy persons.
The proposed method is examined 154 people, including 110 patients with different pathologies and 44 healthy persons. 72 people were established by the claimed method for the diagnosis of functional disorder of the liver.
Patient L., age 79. Entered NCN RAMS with Acute ischemic stroke in the left middle cerebral artery with the formation of a heart attack. The study proposed method on the day of receipt.
Table 1 presents the data and the percentage change before and after MP.
A comparative analysis of the obtained values with the same name in healthy individuals showed that the patient L. there is a violation of the functional state of the liver.
Along with the main course of treatment was recommended additional therapeutic correction of hepatic within 1 month. After 1 month, a repeat survey was conducted in this way. Table 2 presents the data and the percentage change before and after MP.
Comparative analysis of the obtained values with those in healthy individuals showed that almost all values were in the normal range, and when comparing the data with the values from the previous analysis identified the improvement of the functional state of the liver, which confirmed the effectiveness of the conducted terapeuticas the second correction.
Patient K., 49 years. Entered NCN RAMS with acute violation of cerebral circulation with the development of myocardial infarction in the deep sections of the right hemisphere of the brain. The study proposed method on the day of receipt. Table 3 presents the data and the percentage change before and after MP.
A comparative analysis of the obtained values with the same name in healthy individuals showed that the patient had To. there is a violation of the functional state of the liver.
Along with the main course of treatment was not carried out additional therapeutic correction of the control.
After 1 month, a repeat survey was conducted in this way. Table 4 presents the data and the percentage change before and after MP.
Results were compared with those in healthy individuals showed that the patient had To. an infringement of the functional state of the liver. Thus, there is a deterioration in functional status compared with the primary survey of the proposed method, which is manifested not only increased the indices of the studied parameters during cuff samples, but also increase their initial level (before cuff samples) above normal, which is a direct sign of the functional state of the liver.
From the two examples above, reveals medical and clinical effectiveness of the proposed method lies in the possibility of holding early diagnosis of functional disorders of the liver, prior to the development of clinical manifestations of impaired its functioning. Early diagnosis of disorders functioning the project for a liver in this way allows you to assign and to spend adequate therapeutic treatment by hepatic and, possibly prevent further deterioration of its functioning (as in example 1).
Way early laboratory diagnosis of disorders of the functional state of the liver by measuring the activity of the enzymes ALT, AST, LDH, GGT, alkaline phosphatase, total bilirubin, characterized in that it further conduct a three-minute occlusion of the vessels of the shoulder - "cuff test" (MP) to create short-term hypoxia, under the influence of which is metabolic response, and determine the indices of the functional activity of the liver, which shows the relationship of these indicators before and after the implementation of the MP by the following formulas:
Index ALT = ((ALT after MP - ALT to MP)/ALT to MP)·100%
Index AST = ((AST after MP - ACT to MP)/AST to MP)·100%
The index of total LDH = ((LDH after MP - LDH to MP)/LDH to MP)·100%
The alkaline phosphatase index = ((alkaline phosphatase after MP - alkaline phosphatase to MP)/alkaline phosphatase to MP)·100%
Index GGT = ((HPT after MP - GGT to MP)/GGT to MP)·100%
Index Bellyrub. = ((Bilirubin after MP - Bilirubin up to MP)/Bilirubin up to MP)·100%,
upon detection of the increase of these indices by more than 10% can be diagnosed early violation of the functional state of the liver.
SUBSTANCE: pregnant woman suffering hypotheriosis and obesity on their 2-12 weeks of gestation are examined for a fT4 level. If the fT4 values are less than 10 pmol/l, macrosomic delivery is predicted.
EFFECT: use of the method enables high-accuracy prediction of macrosomic delivery.
SUBSTANCE: multiple urine samples are taken during external exposure on a body for one day. Each sample is examined for the concentrations of thiols and urochrome that is followed by calculation of a thiol-urochrome coefficient (TUC) as a relation of the concentrations of thiols and urochrome. If the TUC value is 1.46±0.2, the body status is stated to be satisfactory. The TUC value more than 1.66 or less than 1.26 enables to state the status beyond the satisfactory limits.
EFFECT: use of the method allows analysing dynamics of the antioxidant body status, response to the external exposure, including to cosmophysical.
3 tbl, 3 ex, 3 dwg
SUBSTANCE: pH of thrombocyte-poor plasma, and a diagnostic coefficient D is calculated by formula: D=const1xPPP-const2, where D is a diagnostically significant coefficient, PPP is a pH value of thrombocyte-poor plasma of an examined patient, const1=18.877, const2=139.381. If D is less than 0.25, thrombocyte hyperaggregation is stated reliably, and the value of D exceeding 0.25 makes to state reliably the absence of thrombocyte hyperaggregation signs.
EFFECT: use of the declared technique allows high-accurate and sensitive evaluation of thrombocyte hyperaggregation.
SUBSTANCE: invention describes a method for determining antibacterial resistance of a human body in diseases caused by a staphylococcus infection, based on blood neutrophil analysis; functional activity of neutrophilic granulocytes of patient's peripheral blood is determined by chemoluminescence with calculating a bacterial activation index (the BAI-index) of neutrophils representing the relation of an area under a curve of neutrophilic granulocyte chemoluminescence induced by Staphylococcus epidermidis bacteria to an area under a curve of spontaneous neutrophilic granulocyte chemoluminescence, and if the derived value is less than 1.47, a high level of antibacterial resistance is stated, while the derived values 1.47 and more shows a low level of antibacterial body resistance.
EFFECT: method is informative, precise, complies with the modern requirements for laboratory diagnostic techniques and allows predicting a nature, a clinical course period and bacterial complications in the patients of various groups.
1 ex, 2 tbl
SUBSTANCE: method for prediction of rate of acute infectious diseases in infants with determining the immune status values on the first and fifth postnatal day: absolute lymphocyte count, differentiation marker carriers CD3, CD4, CD8, CD 19, CD56, CD95, a spontaneous nitroblue tetrazolium test value (NBTsp), a level of a phagocytic coefficient (PC), blood serum immunoglobulin A, M, G (IgA, IgM, IgG) concentrations, and further calculating a forecasting index (Ifor) with using a certain equation of multiple linear regression if Ifor does not exceed 3.2, a probability of no more than one acute infectious disease in an infant is concluded; if Ifor is within 3.2-3.7, 2 to 5 probable acute infectious diseases in an infant is stated; if Ifor exceeds 3.7, probability of more than 5 acute infectious diseases in an infant is concluded.
EFFECT: higher prediction accuracy.
SUBSTANCE: complete blood count is performed, and the leukogram components are used to calculate integral hematological values: Calph-Caliph leucocytic intoxication index - LII1, Ostrovsky leucocytic intoxication index - LII2, stress index - SI, neutrophil-lymphocyte index - NLI, neutrophil-monocyte index - NMI, lymphocyte-monocyte index - LMI. If observing the values LII1≤2.5, LII2≤2.75, SI≤1.0, NLI≤11.0, NMI≤16.0, LMI≤2.0, a mild severity is detected. The values LII1 2.6 to 4.5, LII2 2.76 to 5.0, SI 1.1 to 2.0, NLI 11.1 to 15.0, NMI 16.1 to 24.0, LMI 2.1 to 2.5 enables to predict a moderate severity level. A severe level is ensured by LII1> 4.5, LII2> 5.0, SI> 2.0, NLI> 15.0, NMI> 24.0, LMI> 2.5.
EFFECT: use of the declared method allows higher objectivity of determining severity level of acute pancreatitis.
4 ex, 2 tbl
SUBSTANCE: method of early solid malignant disease staging (at the stage of provisional clinical diagnosis) by cell number with stable ontogenetic disorders detected in patient's peripheral blood lymphocytes by quantitative and qualitative analysis of stable chromosomal and genomic disorders in metaphase plates from patient's peripheral blood lymphocytes.
EFFECT: method enables following disease change shift in response to treatment and determining clinical effectiveness.
5 ex, 1 tbl
SUBSTANCE: method of diagnosing rejection of kidney allotransplant includes determination of phase height PH of peripheral blood live lymphocytes by method of phase-interference microscopy, determination of quantity of lymphocytes with phase height PH≤1.5 mcm, 1.5 mcm<PH≤2 mcm, 2 mcm<PH≤2.5 mcm, PH>2.5 mcm, selection of lymphocyte activity coefficients for each limit, said phase heights of lymphocytes equal k3=3, k2=2, k1=1, k0=0 respectively. Obtained data are used to determine functional activity of lymphocytes in sample by formula: FA=(k3n3+k2n2+k1n1+k0n0)/n, where n is number of lymphocytes in sample, n3 is number of lymphocytes with PH≤1.5 mcm, n2 is number of lymphocytes with 1.5 mcm<PH≤2 mcm, n1 is number of lymphocytes with 2 mcm<PH≤2.5 mcm, n0 is number of lymphocytes with PH>2.5 mcm, k3, k2, k1, k0 are coefficients of lymphocyte activity, and if value of lymphocyte functional activity is within FA=1.8-2.0, rejection of kidney transplant is diagnosed.
EFFECT: application of claimed method makes it possible to set diagnosis in due time, which considerably increases efficiency of anti-crisis therapy in post-transplantation period.
2 ex, 1 tbl
SUBSTANCE: claimed is method of diagnosing antioxidant function of membranes of erythrocytes in case of exacerbation of herpes-viral infection. Method lies in determination of superoxide dismutase concentration and titre of antibodies to herpes virus by method of immunosorbent assay (ELISA) of peripheral blood in pregnant women after exacerbation of herpes-virus infection. If superoxide dismutase concentration is 297.63±13.16 Unit/gHb (control - 386.77±13.12 Unit/gHb), titre of antibodies to herpes virus in peripheral blood of pregnant woman constituted 1:3200. If titre of antibodies is 1:6400, superoxide dismutase concentration decreased to 243.85±7.71 Unit/gHb (control - 386.77±13.12 Unit/gHb; p<0.001).
EFFECT: reduction of superoxide dismutase concentration in erythrocytes of peripheral blood in pregnant women during exacerbation of herpes-virus infection predicts reduction of protective reaction of toxic impact of lipid peroxidation on membranes of erythrocytes, increasing risk of their destruction.
SUBSTANCE: essence of method of predicting character of progressing course of chronic kidney disease (CKD) lies in determination of blood coagulation characteristics: activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin time (TT), antithrombin III (ATIII) level, von Willebrand factor (WF), endothelin-1 (E-1), D-dimer. If aPTT indices are within the range from 28 to 35 seconds, PT is from 12 to 15 seconds, TT is from 9 to 13 seconds, ATIII level is from 29 to 70%, WF level is from 105 to 115%, E-1 does nor exceed 0.32 fmol/ml and D-dimer is from 245 to 520 ng/ml FEU slow progressing of CKD is predicted. If aPTT, PT, TT, ATIII level are the same, and WF is higher than 115%, E-1 is higher than 0.32 fmol/ml, D-dimer is higher than 620 ng/ml FEU, accelerated CKD progressing is predicted.
EFFECT: increase of accuracy and reliability of chronic kidney disease diagnostics.
2 ex, 2 tbl
SUBSTANCE: invention relates to medical equipment and can be used in 24-hour monitoring of arterial pressure in conditions of free motor activity of person. Device contains measuring and compensational pulse wave sensors. Measuring sensor is placed under pneumatic cuff in place of brachial artery location. Compensational sensor is identical with measuring sensor and is placed symmetrically on diametrically opposite side of arm. Outlets of measuring and compensational pulse wave sensors are switched to respective amplifiers, whose amplification coefficients are selected on condition of ensuring equality of outlet signals from amplifiers in case of equal physical impact on both sensors. Outputs of amplifiers are switched to subtracter, whose outlet is switched to band filter.
EFFECT: application of invention will make it possible to increase accuracy and reliability of determination of systolic and diastolic values of arterial pressure, including conditions of motor activity of person.
SUBSTANCE: group of inventions relates to medicine and is used for measurement of blood pressure value by winding around living organism. Sphygmomanometre cuff contains soft reservoir for flowing medium, which is pumped/compressed by inlet/outlet of flowing medium, which includes compressing surface, located from the side of "living organism", covering element, which inside includes soft reservoir for flowing medium, covering element includes sheet part of internal peripheral side, located from the side if living organism, and shock absorbing material, located from the same side of sheet part of internal peripheral side as compressing surface, and compressed in the direction parallel to direction of thickness of sheet part and internal peripheral part, where shock-absorbing material is located in such a way that it covers entire surface of compressing surface. Sheet part of internal peripheral side has double-layer structure with space inside. Shock-absorbing material is located in said space. Described is sphygmomanometre, which includes cuff, pumping/compressing mechanism, device for pressure measurement and device for calculation of blood pressure value.
EFFECT: excluding jamming tissues of organism in cuff creases.
8 cl, 30 dwg
SUBSTANCE: invention relates to medical equipment, namely to devices for blood pressure measurement. Device for blood pressure measurement contains measuring cover for flowing medium, sensor for measuring change of internal pressure of measuring cover, first unit of setting parametre in accordance with the information, relating to clothes on the section of measurement, and unit of blood pressure value calculation. Method of processing data of measurement, obtained by means of the device lies in the following: parametre is set in accordance with the information relating to the clothes on the section of measurement of the person and blood pressure value is calculated using parametre based on change of internal pressure of measuring cover. Data processing is carried out by means of machine-readable information carrier, which contains programme product.
EFFECT: application of the invention makes it possible to increase measurement accuracy in case when blood pressure is measured in patient over clothing.
9 cl, 14 dwg
SUBSTANCE: group of inventions relates to medical equipment, namely, to devices for measurement of arterial pressure and methods of remote control and monitoring. Device comprises collar connected to unit for creation and collapse of pressure in collar, connected to one of inlets and outlets of arterial pressure detection unit, clock microelectronic circuit and control unit. Outlets of pressure detection unit, clock microelectronic circuit and control unit are connected to inlets of processor, outlets of which are connected to display unit, unit of arterial pressure detection and clock microelectronic circuit. Device includes cellular module arranged with the possibility to send and receive SMS messages, inlet and outlet of which are connected to one of inlets and outlets of processor. Control unit is equipped with switches to program mode of data transfer. Method for remote control and monitoring of arterial pressure consists in setting parametres of measurement mode and control of arterial pressure metre, measurement and analysis of data of arterial pressure in patient, reproduction and transfer of data. At the same time a digital identifier is previously assigned to metre of arterial pressure, and cellular module is installed in it. Results of measurements are periodically sent to individual page of medical Internet site user, where identification is carried out by digital identifier and internal identifier of cellular module.
EFFECT: using group of inventions makes it possible to improve convenience of arterial pressure monitoring.
10 cl, 4 dwg
SUBSTANCE: invention relates to medical equipment, namely to electronic manometre and method of its functioning. Manometre contains cuff, fixed to place of blood pressure measurement, unit of pressure regulation applied to cuff, unit of registration of pressure inside cuff, unit of artery volume registration and measuring unit for regulation of artery volume of subject of measurement. Measuring unit includes unit of maintaining pressure, control unit with feedback for control of unit of pressure regulation and unit of withdrawal for pressure withdrawal. Method of manometre functioning lies in the following: pressure, at which amplitude of signal about artery of subject of measurement becomes maximal, is registered, registered pressure is supported inside cuff, pressure applied to cuff is regulated in such way that amplitude of signal about artery volume became minimal. As blood pressure, pressure inside cuff, at which amplitude becomes minimal, is taken.
EFFECT: invention allows to measure blood pressure by method of volume compensation determining control value for short period of time.
7 cl, 7 dwg
FIELD: measuring equipment.
SUBSTANCE: invention relates to test equipment and is used in stricture of testing unit for metrological certification of measuring instruments for blood pressure and heart rate. In imitation model of a human hand for testing blood pressure and heart rate, comprising a cylinder for connection of the first type compression cuff of a sphygmomanometre, which contains a flexible tube imitating brachial artery of a human hand, there is a second cylinder for connecting the second type compression cuff of a sphygmomanometre, where a flexible tube with a locking-adjusting element imitating an artery in the human hand wrist, while the cylinders cavities are made with the possibility of hydraulic integration.
EFFECT: widening of the range of calibrated automated sphygmomanometres with cuffs on both a shoulder and a wrist on the same calibration device.
3 cl, 2 dwg
SUBSTANCE: device relates to medical equipment and is intended to measure arterial pressure and pulse frequency. Add-on includes hollow body, pressure sensor, metering feeler with reference bar, at the same time hollow body is arranged in the form of mechanical pen and comprises capacitor, electronic unit of interfacing with cellular phone and connection cable for it.
EFFECT: using invention makes it possible to measure arterial pressure and frequency of person's pulse without cuff, using cellular phone or computer.
SUBSTANCE: invention refers to medicine, namely to obstetrics, and concerns the correction of antihypertensive preparations (AHP) dosage in pregnant women with arterial hypertension. It involves Doppler ultrasound of the "mother-placenta-foetus" system. The uteroplacental misperfusion severity is evaluated. The IA or IB severity level require the AHP dosage to be reduced by 25% as compared to the initial one, while in the II severity level, the dosage is to be reduced by 50%, and in the III severity level - by 75%.
EFFECT: method provides optimised antihypertensive therapy in the pregnant women with taking into account the misperfusion severity level in the "mother-placenta-foetus" system, and as consequence, decreased number of foetal growth inhibition cases and improvement of pregnancy terminations.
SUBSTANCE: invention refers to medical equipment, namely to cardiologic diagnostic devices and represents a sphygmic activity metre. The metre comprises a pilot converter in the form of a hollow box that accommodates a balance arm attached on its inside cap on a feathering hinge. The first and second MEMS accelerometres are fixed on the ends of the balance arms. A bottom of the box has two apertures, one of which is covered with an elastic membrane with a metallised inner side with the first MEMS accelerometre attached to its centre. An annular electret with a metallised upper plane is rigidly fixed in the box above the elastic membrane. The second aperture covers a pressure sensor. An output of the first MEMS accelerometre is connected to a true input of a differential amplifier. An output of the second MEMS accelerometre is connected to a complemented input of the differential amplifier. An output of the differential amplifier is connected with an input of an integrator. The metallised inner side of the elastic membrane and the metallised upper plane of the electret are connected with inputs of a voltage amplifier. The output of the differential amplifier is an output of an acceleration sphygmogram of the sphygmic activity metre. An output of the integrator is an output of a speed sphygmogram of the sphygmic activity metre. An output of the voltage amplifier is an output of a travel sphygmogram of the sphygmic activity metre. An output of the pressure sensor is an output of pulse wave pressure of the sphygmic activity metre.
EFFECT: use of the invention enhances the metre and allows to use the same metre for describing various characteristics of sphygmic activity and their phase relations.
2 cl, 2 dwg
SUBSTANCE: invention relates to medical equipment, namely to electronic sphygmomanometre. Sphygmomanometre contains a block of blood pressure measurement for blood pressure measurement, the first component of storage for keeping information of measurement results, display unit to display the measurement results, the first input unit and the component of activation control. The input unit enables the user to enter a command to activate one of numerous functions included in the first functional group and the second functional group of electronic sphygmomanometre. Activation management component includes the definition module and the command module, it also activates one of numerous functions on the basis of the command signal from the first input unit.
EFFECT: invention enables to disactivate erasure of values and change the values given by the patient.
10 cl, 8 dwg
FIELD: medicinal equipment.
SUBSTANCE: the present innovation deals with devices for measuring patient's blood pressure. The suggested device contains inflatable gasket designed with possibility to be fixed around patient's shoulder or wrist. The device is supplied with either electric or electronic pressure pickup unit and is being a manual device containing a bulb indicated for inflating a gasket and a body which, in its turn contains a unit to control and depict information. Blood pressure is automatically detected based upon oscillometric technique. The suggested device enables to simply and accurately measure patient's blood pressure, moreover, it has got low power supply, provides better comfort for a patient to measure blood pressure and provides increased reliability of the device to control blood pressure.
EFFECT: higher efficiency of blood pressure measurement.
6 cl, 3 dwg