Method of determining functional state of hemostasis system
SUBSTANCE: for determination of functional state of hemostasis system record of blood coagulation process is performed, current amplitude of blood resistance in first time moment is registered and second resistance of blood at multiple time moment from initial time value is measured. Two resistances and time moments are used to determine maximum blood resistance and time constant, by which blood resistance at the beginning and end of coagulation process is calculated. Obtained parameters are used to determine indices of beginning and end of blood coagulation process. Obtained indices are compared with of the same name indices of blood coagulation process in norm and in case of differently directed deviations disturbances of functional state of hemostasis system are diagnosed.
EFFECT: invention makes it possible to increase measurement accuracy and reduce examination time.
1 tbl, 4 dwg
The present invention relates to medicine, namely to hemocoagulase, and can be used to identify individuals at risk of developing hemocoagulation complications.
Famous instrumental method of assessing the functional state of hemostasis - thromboelastography (TAG), consisting of a graphic (photo-optical or mechanical) check the viscosity of blood and plasma in the process of coagulation, followed by determination of indicators thromboelastogram that characterize the process [USSR Author's certificate N 1520450, M CL G01N 33/86, publ. 07.11.89, BI N 41].
The disadvantages of this method are: low sensitivity and reproducibility, the inability to detect subtle changes in the blood clotting system and conduct an analytical assessment of the identified violations.
There is a method of determining the functional status of the hemostatic system by registering electrocochleography blood [see the book. Koblov L. F. Methods and instruments for the study of hemostasis. - M.: Medicine, 1975, p.75-79], which consists in the registration of the change of electrical resistance of the blood sample filled in a cell with two electrodes. The cell performs oscillatory motion, allowing the blood alternately closes and opens the electrodes. Record of the research takes the form of a number of peri is legal pulses with a repetition rate of 0.1 Hz (6 pulses per minute), envelope which describes the process of blood clotting. The amplitude of the pulses corresponds to the resistance of the blood, in the moment between the electrodes of the measuring cell. When evaluating electrocochleography take into account the following parameters: T1 is the start time of the collapse: T2 is the end time of the collapse; T - duration of coagulation; Am is the maximum amplitude; AO is the minimum amplitude. By changing these parameters get ideas about various disorders of the blood coagulation system.
The disadvantages of this method are the inertia, the relatively low accuracy and sensitivity of measurements due to leakage intense side of physico-chemical processes related to the movement of the electrodes and studied medium relative to each other.
For the prototype accepted method for determining the functional state of the hemostatic system [see RF patent №2109297, G01N 33/86, 1998], namely, that performs the measurements of the amplitudes of the recording process of blood clotting in the beginning, then after one, two and three minutes from the beginning determine the speed of blood clotting for the second and third minutes, calculate return them to the values and compare all four with the same blood clotting is normal. In the presence of different abnormalities diagnosed on Uchenie functional state of the hemostatic system.
The disadvantages of the prototype are low accuracy and the duration of its execution.
The technical objective of the method is the improvement of metrological performance, namely, measurement accuracy, and reducing research time.
The goal of the project is achieved as follows.
In the method for determining the functional state of the hemostatic system consists in the fact that they are carrying out the measurement of the amplitude of the recording process of blood clotting in the beginning, determine the indices of the beginning and end of the clotting process electrocochleography blood and compare them with the same indicators of blood coagulation in normal and multidirectional deviations diagnose disorders of the functional state of the hemostatic system, unlike the prototype, register the current amplitude of the resistance of the blood in the first time and measuring a second resistance of blood in multiples of time from the initial time values for the two resistors and the moments of time are the ultimate resistance of the blood and the time constant, which is calculated the resistance of blood at the beginning and end of the clotting process and found the settings determine the indices of the beginning and end of the process of blood clotting.
The essence of the proposed method is illustrated in figure 1-3 Offer ways which includes 2 steps.
1. The measurement limit of the resistance of the blood and the time constant.
2. The indicators of the beginning and end of the process of blood clotting on the measured amplitudes of the resistance.
1. The indices of the beginning and end of the process of coagulation of blood is determined by measuring the limiting resistance of the blood, the time constant and resistance of blood at the beginning and end of the clotting process. To do this, hold the amplitude measurement process of blood clotting in the beginning and define the indicators of early Tnand the end of the clotting process Tto. Compare them with the same indicators of blood coagulation in normal and multidirectional deviations diagnose disorders of the functional state of the hemostatic system.
To do this, register at time t1the current amplitude of the resistance R1in a multiple of the time t2(t2=k·t1when an integer factor of multiplicity k≥2) from the original time measuring a second resistance R2(figure 1). Two resistance R1, R2and the moments of time t1, t2find the value of the limiting resistance R0in the blood sample, the time constant T, which define the start and end of the clotting process.
The experimental dependence of the resistivity R(t)=R dinamicheskoj the process (figure 1, curve 1) are approximated by the exponential law (Fig 1, curve 2):
The dependence (1) connects the measured value of the amplitude R of the resistance at time t research, with a limit of R0resistance and time constant T.
Unique property parameters R0and T is independent from the characteristics of the variable resistance R and time t, i.e. they uniquely identify the dynamic characteristics of the experiment according to (1), therefore, they should be taken for informative parameters of the dynamic process.
The definition of informative parameters R0and T is organized by two measured values of amplitude R1, R2resistance at two points in time t1, t2from the system of equations for the first and second measurement:
Divide the rst equation by the second:
and lead him to a form convenient for taking the logarithm:
Logarithmorum both parts of the equations and Express T:
Constitute a system of equations for calculation of the parameter R0:
Divide the rst equation by the second:
and bring him to mind:
Exponential this equation and Express the extreme resistance R0:
Substitute the values of the parameters R0and T in the formula (1), which approximate the experimental dynamic resistance curve of blood (figure 1, curve 2).
2. The start time Tnand the end of Ttoclotting of blood is determined from the expression (1) by the formulas:
where T is the time constant;
R0the ultimate resistance of blood;
Rnand Rtothe resistance of the blood, respectively at the beginning and end of the clotting process.
Define the start and end of the process of blood coagulation by the formulas (4) using the experimental dependence (figure 2).
Figure 2 shows curves of the coagulation characteristic of a healthy person (curve 1), for a patient with hemophilia (curve 2)for a patient with thrombophilia (curve 3). From figure 2 it is seen that the initial resistance of blood for a patient with hemophilia increases, and for a patient with thrombophilia is reduced.
Let us prove the efficiency of the analytical method of determining the clotting time of blood relative to the graphical method.
According the rototype time to begin the process of blood clotting T ndetermine graphically from the beginning of the study to first reduce the amplitude of the resistance of the blood, and the end time of the clotting process Ttodetermine from the beginning of the study to the first oscillation with a minimum amplitude (figure 3). However, to accurately register a moment of hesitation with a reduced amplitude graphically quite difficult.
Since the pulses follow with a frequency of 0.1 Hz or latitude 10 seconds, then the resistance of blood at the beginning and at the end of the process of coagulation is determined with an error of 10%.
Therefore, the start time of blood clotting T1and T2in the prototype will be determined by the formula:
In the proposed method, the start and end of the process of blood clotting determined analytically according to the first formula of equation system (4).
Metrological efficiency ηiby the time blood clotting,is determined by the relation Tn(the start time of the collapse, the proposed method) to Ti(the start time of the collapse in the prototype):
Substituting formulas (4) and (5) into the formula (6) we obtain:
Substituting in these equations the experimental values obtained
analytically and graphically, obtain the value of the η 1and η2.
Table 1 shows the values of the errors in the measurement start time and the end of the blood clotting process to discard the value of the measured resistance of blood at 1%, 5% and 10%.
|The estimation of the measurement uncertainty|
|R %||Tn, %||Tto, %|
Therefore, determination of the limiting resistance of the blood and the time constant allows, in contrast to the prototype, to improve the accuracy of measurement of clotting time of blood 10 times.
In the proposed solution the definition of informative parameters of blood involves analytical measurements that allow you to automate the determination of the functional state of the hemostatic system, unlike the prototype, in which characteristics determine graphically. Efficiency is the ability for efficiency, defined as the ratio between the total times of the analytical control τ 1and graphical analysis τ2. The analytical control in m times less time subjective analysis and differs at least 10 times. This implies that the efficiency for efficiency, ψ is equal to:
i.e. efficiency in efficiency in the proposed solution is not less than an order of magnitude higher than known solutions.
Figure 4 presents the analysis of experimental data the proposed method, proving the adequacy of the results of the analytical control of biomedical experiment (for a healthy person - curves 1, for a patient with hemophilia curves 2, for a patient with thrombophilia - curves 3).
Thus, the method of determining the functional state of hemostasis by informative parameters: the maximum resistance of blood and continuous time, in contrast to known solutions, improves the accuracy and efficiency of measurement of clotting time of blood is no less than an order of magnitude and allows you to automate the control of hemostasis. Ultimately increases the reliability of the measurements and expands the range of control hemocoagulase, which reduces the risk of hemocoagulation complications.
The method for determining the functional state of the hemostatic system consists in the fact that they are carrying out the measurement of the amplitude of the recording process of blood clotting in his early is e, determine the indices of the beginning and end of the clotting process electrocochleography blood and compare them with the same indicators of blood coagulation in normal and multidirectional deviations diagnose disorders of the functional state of the hemostatic system, wherein registering the current amplitude of the resistance of the blood in the first time and measuring a second resistance of blood in multiples of time from the initial time values for the two resistors and the moments of time are the ultimate resistance of the blood and the time constant, which calculates the resistance of blood at the beginning and end of the clotting process and found the settings determine the indices of the beginning and end of the process of blood clotting.
SUBSTANCE: method is based on a method of observing turbidimetric fibrin clot formation with optical transmission of an incubation medium recorded by ultraviolet radiation band 230 to 320 nm by means of UV-spectrophotometre as a fibrin-polymer detector.
EFFECT: invention enables higher accuracy and sensitivity of the method.
4 ex, 4 dwg
SUBSTANCE: for thrombin production measurement, a layer of said sample contacts with a fluorogenic substratum of thrombin where the thickness of said layer is 0.05 to 5 mm, while the surface area is 10 to 500 mm2. Further, the thrombin production environment in said sample is provided. It is followed by measuring the fluorescence emitted from the layer surface by a fluorescent group released by the fluorescent substratum as a result of an enzymatic action of produced thrombin on said fluorogenic substratum. Besides, the invention ensures a kit for measuring the thrombin activity in the sample.
EFFECT: higher measuring accuracy.
29 cl, 12 dwg, 5 ex
SUBSTANCE: blood is examined. A hematocrit level (H), erythrocyte count (E), thrombocyte count (T) are determined. Said parametres are evaluated. In the event if they keep within the determined limits for the patients with acute coronary syndrome (ACS), then adenosine phosphate induced (ADP-induced) clotting time test samples are prepared. Citrated blood sample 0.4 ml is prepared of whole blood and divided on two samples 0.2 ml. Each of these samples is introduced in a measuring cell, recalcified at temperature 37°C for 2 minutes. Then a magnetic ball mixer is placed in each cell. The measurement is activated, and in three seconds the ADP solution 0.1 ml is introduced. After a clotting reaction, a process time duration is recorded separately for each sample. An arithmetical mean of the derived values is calculated (A). The derived values of each of said parameters are scored. Total score Σ=A+H+E+P shows the risk of recurrent thrombotic events. If Σ=4 points, the low risk is observed; the value Σ=5-6 points shows the medium risk, while Σ=7-10 points - the high risk.
EFFECT: method provides more objective risk evaluation of recurrent thrombotic events in the patients with ACS with its simplicity and low cost.
1 ex, 1 tbl
SUBSTANCE: blood sample is placed in capillary, in whose walls installed are electrodes connected to frequency generator and registering unit, blood electric conductivity is measured at the moment of passing through it of alternating current with frequency 200 Hz, electric coagulogram is registered and used to determine chronometric and amplitude characteristics: A - amplitude of functional curve decline, mV; N - time of functional curve decline to minimal value in minutes. If value of A/T index decreases or increases with respect to normal, conclusion about hemostatic disorders is made. If value of A/T index equals 3-5 - hemostasis state is evaluated as normal, if A/T value is lower than 3, hypocoagulation is determined, and if A/T value is higher than 5 - hypercoagulation.
EFFECT: application of the method makes it possible to obtain data about hemostasis system state in real time mode, without injuring form blood elements in investigated microvolumes of blood, thus making it possible to increase accuracy, self-descriptiveness and efficiency of hemostasis state evaluation and to carry out correction of performed therapy without delay.
4 dwg, 3 ex
SUBSTANCE: in patients with IHD before therapy with acetylsalisylic acid (ASA) ADP-induced and ASA-dependent platelet aggregation are examined and by their difference value of coefficient of aggregation inhibition (CAI) is calculated. CAI value <24% testifies to resistance to ASA, if CAI ≥24% - about sensitivity to ASA.
EFFECT: method ensures high prediction accuracy and makes it possible to prevent development of undesirable coronary events in IHD patients.
1 tbl, 4 ex, 4 dwg
SUBSTANCE: invention refers to medicine, namely to haematology, and orthopaedics. The intravascular thrombocyte activity correction in children with scoliosis requires the prescription for at least 6 months of a therapeutic complex which involves daily therapeutic physical training, two courses of massage and daily swimming for at least 20 minutes a day.
EFFECT: method allows to normalise intravascular thrombocyte activity in children aged 8-12 with scoliosis, to improve tissue microcirculation considerably, to optimise growth and development of skeleton and internals.
SUBSTANCE: invention belongs to medicine, notably to haematology and orthopaedics. For thromboplastin synthesis correction in children 8-12 years old with scoliosis is prescribed complex of treatment, including daily remedial gymnastics, two courses of massage and daily swimming for at least 20 minutes a day, during 6 months.
EFFECT: method enables thromboplastin synthesis normalisation in children with scoliosis, significantly sanitate children with scoliosis due to improvement of tissues' microcirculation.
SUBSTANCE: invention refers to medicine, namely to aggressive medical therapy, resuscitation science, critical care medicine, laboratory diagnostics and can be used by resuscitators, intensivists, laboratory doctors for well-timed diagnosis and consequently, for individualised aggressive medical therapy of acute disseminated intravascular coagulation. The integrated assessment of links of haemostatic system and the clinical appraisal of organ dysfunction are applied in a measurer, and when observing structural hypercoagulation characterised by fibrinogen level increase, thrombocyte activity increase, growth of soluble fibrin complex (SFC) level, and also when observing chronometric hypercoagulation characterised by time tests, palette-derived factor 4 activity (P4) with manifested petechial haemorrhage and organ dysfunction, and coagulation cascade activation with underlying depression of antithrombin III and protein C, a hypercoagulation stage of acute DIC is diagnosed. Chronometric hypercoagulation by Activated partial thromboplastin time (APTT), INR, fibrinogen and P4 with manifested signs of structural hypocoagulation by thrombin time prolongation and D-dimer activity increase with underlying further intensification of anticoagulant system deficiency, progression of target organs dysfunction and mixed haemorrhage show a transitive stage of acute DIC. If observing said hypocoagulation changes and disturbed fibrinolytic activity with prevailing either decompensated organ and tissue dysfunction, or hemorrhagic syndrome up to system haemorrhages, or their combination with hemorrhagic syndrome characterised by polymorphism of clinical picture and localisation: petechial-haematoma haemorrhage at the stress-induced stomach ulcers, hematuria, a coagulopathy stage of acute DIC is diagnosed that is characterised either by depression of fibrinolysis, or preserved fibrinolytic activity, or by activation of secondary fibrinolysis, or by acute primary fibrinolysis.
EFFECT: method allows optimising classification of acute disseminated intravascular coagulation, improving diagnostic significance of the classification and simplifying a diagnostic prospecting which provide a basis to consider the staging of acute disseminated intravascular coagulation.
1 dwg, 4 ex
SUBSTANCE: invention refers to medicine, namely to haematology and orthopaedics. Correction of blood microvesicle level in children aged 8-12 with scoliosis is ensured by the prescription of a therapeutic complex that involves daily therapeutic physical training, two courses of massage and daily swimming for at least 20 minutes a day, for at least 6 months.
EFFECT: method enables correcting blood microvesicle level in children aged 8-12 with scoliosis, optimising microcirculation in tissues, normalising functions of the internal organs, growth and development of a child.
SUBSTANCE: invention refers to medicine, namely to haematology, and orthopaedics. Thrombocyte aggregation normalisation in children aged 8-12 with scoliosis is ensured by the prescription of a therapeutic complex that involves daily therapeutic physical training, two courses of massage and daily swimming for at least 20 minutes a day. The therapeutic complex is performed for at least 6 months.
EFFECT: method improves the effectiveness of thrombocyte aggregation correction in children aged 8-12 with scoliosis.
FIELD: medicine, laboratory diagnostics.
SUBSTANCE: the suggested studying should be carried out on the glass simultaneously with several inductors by applying minimal inter-taking antilogarithms concentrations of aggregation inductors which correspond at double combination of inductors: ADP 5.0 x 10-8 M, adrenaline 3.0 x 10-9, collagen - dissolving the main suspension 1:8, thrombin 0.075 U/ml; at triple combination of inductors: ADP 10-9 M, adrenaline 10-9, collagen - dissolving the main suspension 1:9, thrombin 0.060 U/ml. The development of aggregation means thrombocytic activation in patients with arterial hypertension at metabolic syndrome. The method enables to evaluate the changes of thrombocytic functional state with combination of inductors more probably present in area of vascular lesion by applying minimal necessary concentrations that develops real conditions at hemostatic initiation in human vessels.
EFFECT: higher efficiency of studying.
3 dwg, 3 ex, 2 tbl
SUBSTANCE: method involves checking consciousness, blood coagulation state, peripheral blood leukocytes number, K+ ions, bilirubin, fibrinogen, hemolysis and hemoglobinuria availability, prothrombin index and exotoxic shock development. Each value is calculated in points as follows. Lucidity is evaluated as -2 points; depression - +3 points; coma - +6 points; lack of changes in blood coagulation system - -2 points; coagulation availability without clinical injuries - +2 points; coagulopathy with clinical manifestation signs - +19 points; K+ ions concentration being less than 3.0 mmole/l - +3 points, from 3.1 to 3.5 mmole/l - -5 points, from 3.6 to 5.0 mmole/l - 0 points, greater than 5.0 points - +7 points, failure in determining K+ ions concentration - 0 points; hemolysis availability - +6 points, its lack - -3 points; hemoglobinuria availability - +8 points, its lack - -1 points; leukocytes number being less than 12.0x109/l - -2 points, from 12,1 to 18.0x109/l - 0 points, higher than 18.0x109/l - +8 points; hourly urine output being less than 30 ml/h - +6 points, greater than 30 ml/h - -2 points; bilirubin content being less than 31 mcmole/l - -2 points, from 30.1 to 50.0 mcmole/l - 0 points, greater than 50.0 mcmole/l - +2 points, failure in determining bilirubin content due to hemolysis being available -+6 points; prothrombin index being equal to or less than 60% - +3 points, greater than 60% - 0 points, failure in determining prothrombin index due to hemolysis being available - +12 points; fibrinogen concentration in blood plasma being less than 2.1 g/l - +4 points, from 2.1 to 4.0 g/l - -1 point, from 4.1 to 6.0 g/l - +1 point, failure in determining fibrinogen concentration due to erythrocyte hemolysis being available - +13 points; exotoxic shock development - +9 points, its lack - -1 point. The points are summed up. The value being greater than +13, admission for treatment in resuscitation department is indicated. The value being less than -13, admission for treatment in therapeutics department is indicated. The value being from -13 to +13, resuscitation expert consultation is advised.
EFFECT: high evaluation accuracy.
FIELD: medicine, laboratory diagnostics.
SUBSTANCE: one should evaluate the time for clotting of plasma under testing in phospholipid-dependent test, moreover, one should apply high- and low-sensitive thromboplastin reagents to lupus anticoagulant to calculate the ratio of indices of prothrombin time prolongation and at its value being either equal to or above 1.1 one should diagnose APS.
EFFECT: shortened terms of research.
1 ex, 4 tbl
SUBSTANCE: method involves analyzing symptoms manifesting initial disseminated intravascular blood coagulation syndrome danger like burn area, availability of upper air passages burn, shock with its severity degree taken into consideration, sepsis development; clinical manifestations of disseminated intravascular blood coagulation syndrome like lung, kidney, liver function insufficiency, cerebral dysfunction, local and multiple hemorrhages, thrombosis, infarction; homeostasis system laboratory analysis data, hyper- and hypocoagulation based on chronometry test data, number of blood platelets, fibrin-monomer complexes, D-dimers, activity of antithrombin III, C and S proteins, XIIa-dependent fibrinolysis plasminogen content, availability of injured erythrocytes, combinations of laboratory tests for recognizing disseminated intravascular blood coagulation syndrome. Each sign under consideration receives a number of points corresponding to its diagnostic significance and integral value is calculated DIBCSIV=(X1+X2+…+Xn)/n, where n is the number of signs taken into consideration. DIBCSIV value equal to 1.0-1.5 units shows physiological norm. The value being between 1.6 and 2.5 units, light disseminated intravascular blood coagulation syndrome is diagnosed. The value being between 2.6 and 3.5 units, disseminated intravascular blood coagulation syndrome of medium severity is diagnosed; 3.6-4.5 points to one heavy severity degree; 4.6 and greater indicates highly severe case of disseminated intravascular blood coagulation syndrome.
EFFECT: high accuracy and objectiveness in differentiating syndrome severity degrees.
FIELD: medicine, diagnostics.
SUBSTANCE: one should study blood components to detect anticoagulant-fibrinolytic activity. Moreover, patient's blood should be sampled: in whole blood one should detect the presence of affected erythrocytes and evaluate the quantity of thrombocytes, in plasma it is necessary to study the activity of antithrombin III, XIIa-dependent fibrinolysis, the content of soluble fibrin-monomeric complexes, in blood serum of the sample taken one should detect the concentration of urea, creatinine, sodium, albumin, total cholesterol and the activity of aspartate aminotransferase, moreover, one should calculate integral value of renal-hepatic deficiency, to put corresponding point for the degree of parameters under testing, then one should calculate integral value of disseminated intravascular clotting (IVDIC) and at its value being 6.3 U and more DIC-syndrome should be diagnosed, moreover, at IVDIC value ranged 6.3-10.1 U it is possible to diagnose latent DIC-syndrome, at 10.2-14.6 - subacute DIC-syndrome and at 14.7 and higher - acute DIC-syndrome should be concluded.
EFFECT: higher accuracy and efficiency of diagnostics.
4 ex, 2 tbl
FIELD: medicine, obstetrics.
SUBSTANCE: the present innovation deals with predicting disadaptive processes in women in dynamics of menstrual cycle. During menstrual cycle beginning since the 1st d to the 21st d one should detect the dynamics for alteration in coefficient of activity of syntoxic adaptation programs (CASAP), calculated by the following formula:
where CST - concentration of blood serotonin, AAT-III - activity of antithrombin III, Aaoa - total antioxidizing activity of plasma, CCD8 + - concentration of T-suppressors, Cad - concentration of blood adrenalin, Cα2MG - concentration of α2-macroglobulin, CMDA - concentration of malonic dialdehyde, CCD4 + - concentration of T-helpers. Moreover, normally CASAP value alters two-fold against the first day of the cycle - since 0.70 up to 1.40 on the 21st d of the cycle, at no alterations in CASAP value one should diagnose female disadaptive alterations leading to failed pregnancy. The innovation enables to perform diagnostics of disadaptive processes in women in dynamics of menstrual cycle followed by prognostic conclusion upon future pregnancy.
EFFECT: higher accuracy of diagnostics.
SUBSTANCE: method involves determining spontaneous blood platelets aggregation and one induced by adrenalin and collagen, thrombocytospecific peptides activity of β-thromboglobulin and thrombocytic factor 4 in blood plasma.
EFFECT: high accuracy of diagnosis.
SUBSTANCE: method involves determining coagulating blood viscosity values like reaction period r, thrombin constant K, maximum amplitude MA, time T for forming fibrin-thrombocytic blood clot, spontaneous blood platelets aggregation intensity Ar, retraction and spontaneous clot lysis total FA. The r being within 5-7 min, Ar from -2 to -6 relative units, K being within 4-6 min, MA within 500-700 relative units, T within 40-60 min and FA equal to 10-20%, low inflammatory process activity is considered to be the case. The r being less than 5 min, Ar equal to -8 to -12 relative units, T less than 40 min and FA less than 10% with no changes in K and MA being observed, inflammatory process activity in chronic glomerulonephritis case is considered to be of high severity degree.
EFFECT: high accuracy of diagnosis; enhanced effectiveness of treatment method selection.
FIELD: medicine, clinical neurology, neurosurgery.
SUBSTANCE: one should study both activation and aggregation of thrombocytes in blood of carotid artery, at the quantity of thrombocytic active forms being above 70% and the number of aggregated thrombocytes being above 9.0% one should predict the development of cerebral ischemic lesion along with stable focal neurological symptomatology, and at the quantity of thrombocytic active forms being below 30% and the number of aggregated thrombocytes being below 8.0% it is possible to predict positive dynamics in the course of the disease mentioned without developing cerebral ischemic lesion.
EFFECT: higher accuracy of prediction.
FIELD: medicine, clinical neurology, neurosurgery.
SUBSTANCE: one should study the level of von Willebrand's factor in patient's carotid artery blood. At its content being below 105% one should predict the development of repeated AICH. The innovation improved information value of testing due to possibility to obtain reliable prediction in latent period, as well.
EFFECT: higher accuracy of prediction.
2 ex, 1 tbl