Method of treating patients with scapulohumeral periarthrosis

FIELD: medicine.

SUBSTANCE: scapulohumeral periarthrosis is treated by nonsteroid anti-inflammatory drugs, anaesthetics and vitamins, by local cryotherapy with using Kryotur 600 apparatus immediately followed by neuropulse cuppent therapy. An acute period of the disease requires cryotherapy at temperature (-6) - (-12)°C for 8-10 minutes. In a subacute period not accompanied by secondary synovitis phenomena, cryotherapy is carried out at (0) - (-6)°C for 5-10 minutes. 4 procedure fields are exposed to neuropulse current. The IV channel electrodes are crosswise fixed within a shoulder joint; the I channel electrodes are arranged longitudinally in a paravertebral area on an affected side at a level of the I-III thoracic vertebras; the II channel electrodes are found paravertebrally on an opposite side; the III channel electrodes are fixed within a deltoid muscle. The operating mode of all the channels is group-mixed with pulse current frequency of the IV channel is fixed and equal to 100 Hz, the channel current migration period is 8 seconds. The neuropulse current exposure time is 10-15 minutes. The therapeutic course is 8-10 daily procedures.

EFFECT: higher clinical effectiveness ensured by pain syndrome relief, increased range of shoulder joint movement and lower number of carried out physiotherapeutic procedures.

4 ex

 

The invention relates to medicine, namely to traumatology and orthopedics, and physical therapy, and can be used in the treatment of patients humeroscapular periostracum.

Known methods of treating the sick humeroscapular periostracum, consisting of cryotherapy (General and local body cryotherapy. The collection of articles edited by Rev. - Moscow, 2005. - 36 S. - P.20-21).

As a prototype for closest to the technical nature of the chosen method of treatment of the humeroscapular periostracum, is the impact of local cryotherapy on the shoulder area, as well as in medical exposure, including non-steroidal anti-inflammatory, analgesics and vitamins. Used mobile installation Cryojet 200. The methodology combined. First, a large oval-crevice tool (BOS) have effect for 3-4 minutes on relevant defeat paravertebral zone level vermehrung and niinisalo spine with capture deltoid region. Then the impact of the conduct alternately from side surfaces (lateral and medial) of the upper section of the shoulder toward the deltoid region also 3-4 minutes. After the labile methods determined by palpation pain points. If any impact about the W ill result for 0.5-1 minute for each pain point. The total exposure time should not exceed 3-4 minutes. The rate of 10-12 procedures applied daily with a break at the weekend (General and local body cryotherapy. The collection of articles edited by Rev. - Moscow, 2005. - 36 S. - P.20-21).

The prototype method is not effective enough. Thus, according to the authors of the method prototype, decrease pain occurs only to the 8th - 10th procedure that, in our opinion, is connected with only cryotherapy and the absence of other physical factors. In addition, in this mode the air is cooled to -30°C, served with a large oval-slit and small rounded-slit nozzle hole diameter 1 DM and 1-2 cm, respectively, at different distances (2-7 cm) from the nozzle to the surface of the patient's body, with different rates of flow of the cooled air that does not provide opportunities cryotherapy under different temperature regimes. Obviously, this also affects the relatively low efficiency of treatment. For example, the authors of the prototype method seen a significant increase in the amplitude of movements in the joint only is 52.0% of cases, and when this treatment is 10-12 procedures.

The technical result of the invention is to improve the effectiveness of the treatment by reducing pain, increasing the amplitude of the motion is in the shoulder joint and reduce ongoing physiotherapy.

The technical result is achieved by the fact that provide medical treatment, on the shoulder area are cryotherapy and therapy neiroimmunnye currents. And therapy neiroimmunnye currents is carried out directly after cryotherapy. Medical treatment includes non-steroidal anti-inflammatory, analgesics and vitamins. Local cryotherapy is carried out using apparatus "Kryotur 600", and when the acute phase of upper periostraca cryotherapy is carried out at a temperature exposure - (-6)-(-12)°C, the procedure lasts 8-10 minutes. In the subacute phase of the disease without signs of secondary synovitis cryotherapy is carried out at a temperature of (0)-(-6)°C, duration of treatment is 5 to 10 minutes. Neiroimmunnye currents affect 4 treatment field, and the electrodes of the fourth channel is fixed in the region of the shoulder joint cross; the electrodes of the first channel longitudinally in the paravertebral region on the affected side at level I-III of the thoracic vertebrae; the electrodes II channel - paravertebral on the opposite side; the electrodes of the third channel is fixed in the region of the deltoid muscle. The operation of all channels mixed group, the frequency of the pulse current of the fourth channel is fixed and equal to 100 Hz, the period of migration of the current through the channels is 8 sec. Prodoljitel the ness impact neiroimmunnye currents - 10-15 minutes, the treatment course of 8-10 treatments daily.

The method is as follows.

The patient laid on the couch. Cryotherapy is carried out by means grigorovka apparatus of the "Kryotur 600" (Uniphy Elektromedizin, Germany), which lead to skin around the shoulder joint. The dosage depends on the severity of the process. During exacerbation of upper periostraca cryotherapy is carried out at a temperature of exposure (-6)-(-12)°C, the procedure lasts 8-10 minutes. In the subacute phase of the disease without signs of secondary synovitis cryotherapy is used at a temperature of (0)-(-6)°C, the time required 5-10 minutes. Immediately after cryotherapy carry out impact neiroimmunnye currents. To do this, use the 4-channel device Bioritm-040"that enables simultaneous combined exposure to multiple treatment fields without moving the electrodes, which significantly improves the effectiveness of the treatment. Exercise effects on 4 treatment field. The electrodes of the fourth channel is fixed in the region of the shoulder joint cross; the electrodes of the first channel longitudinally in the paravertebral region on the affected side at level I-III of the thoracic vertebrae; the electrodes II channel - paravertebral on the opposite side; the electrodes of the third channel is fixed in the area of delovi the Noah muscles. The operation of all channels mixed group, the frequency of the pulse current of the fourth channel is fixed and equal to 100 Hz, the period of migration current on channels 8 sec. Duration of exposure neiroimmunnye currents - 10-15 minutes, the treatment course of 8-10 treatments daily.

Distinguishing the essential features of the invention are:

1. Local cryotherapy is carried out using apparatus "Kryotur 600".

2. During exacerbation of upper periostraca cryotherapy is carried out at a temperature of exposure (-6)-(-12)°C, the procedure lasts 8-10 minutes, in the subacute phase of the disease without signs of secondary synovitis cryotherapy is carried out at a temperature of (0)-(-6)°C the duration of the procedure 5-10 minutes.

3. Immediately after cryotherapy additionally the area of the shoulder joint effect neiroimmunnye currents.

4. Neiroimmunnye currents affect 4 treatment field, and the electrodes of the fourth channel is fixed in the region of the shoulder joint cross; the electrodes of the first channel longitudinally in the paravertebral region on the affected side at level I-III of the thoracic vertebrae; the electrodes II channel - paravertebral on the opposite side; the electrodes of the third channel is fixed in the region of the deltoid muscle.

5. The operation of all channels mixed group, the frequency of the pulse is the eye of the fourth channel is fixed and equal to 100 Hz.

6. Migration of current through the channels of 8 seconds.

7. Duration of exposure neiroimmunnye currents - 10-15 minutes.

8. Treatment - 8-10 procedures carried out daily.

The causal link between distinguishing the essential features and achieve the result:

1. Application of the "Kryotur 600" (Uniphy Elektromedizin, Germany) is preferable compared to a mobile installation Cryojet, because it allows you to set the exposure temperature and duration of the treatment.

2. Developed parameters cryotherapy for acute and subacute stages of the disease allow for highly effective treatment of upper periostraca.

3. Additional impact neiroimmunnye currents on the affected shoulder joint it is necessary to enhance the analgesic action and stimulation of reparative-regenerative processes in the shoulder joint and surrounding tissues.

4. Impact neiroimmunnye currents on 4 treatment field due to the fact that the pathological process captures not only the shoulder joint and surrounding tissues.

5. Mode channel group allows simultaneous influence of 4 treatment fields, and mixed mode is required for I-III channels with periodically varying the frequency of the pulse current, and for the fourth channel since f is keravnou frequency of 100 Hz, which mainly exerts analgesic effect.

6. The authors selected the migration period current on channels in 8 seconds, and the duration of exposure neiroimmunnye currents - 10-15 minutes, as these settings ensure maximum effectiveness of the treatment.

7. The number of procedures, that is 8-10 carried out daily, sufficient to obtain the maximum therapeutic effect in contrast to the prototype method, comprising 10-12 sessions.

Examples from clinical practice

Example 1.

And/b 18248. Patient E., 71, retired.

Diagnosis at admission: the Upper periastron right, II phase, the acute phase.

The patient was admitted to the hospital complaining of intense pain in the right shoulder joint, aggravated by moving the hands and laying his hands behind his back.

Objective: tenderness to palpation of the right shoulder joint and surrounding tissues, limiting the amplitude of movement - 3 points. On the radiograph: katowickie changing structures of the head, right shoulder and acromiale process, narrowing of the joint space acromiale-clavicle joint, destructive and bone-traumatic changes it is not revealed.

The course of treatment by the present method was 8 procedures local cryotherapy and therapy neiroimmunnye currents. Appointed traditional medicamentos what I therapy: candles Ketonal 2 times daily rectal, tablets Ketonal Forte 100 mg 2 times a day orally, solutions analgin 50% to 4.0 ml, Dimedrol 1% - 2.0 ml, novocaine 0,5% - 10.0 ml, sodium chloride 0,9% - 200.0 ml intravenous drip No. 5, b vitamins intramuscularly No. 10. Cryotherapy was performed by using the apparatus "Kryotur 600" (Uniphy Elektromedizin, Germany), grigorovka drove on the skin around the right shoulder when the exposure temperature -6°C, duration of treatment was 8 minutes. Immediately after cryotherapy was affected neiroimmunnye currents. Used 4-channel device Bioritm-040". The electrodes of the fourth channel recorded in the area of the right shoulder joint cross; the electrodes of the first channel disposed longitudinally in the right paravertebral region at level I-III of the thoracic vertebrae; the electrodes II channel - left paravertebral level I-III of the thoracic vertebrae; the electrodes of the third channel is recorded in the right deltoid muscle. The operation of all channels mixed group, the frequency of the pulse current of the fourth channel is fixed and equal to 100 Hz, the period of migration current on channels 8 sec. The current strength in the fourth channel was increased until the patient is feeling severe vibration under the electrodes in the first to third channels until muscle contractions. The duration of exposure of 10 minutes. The course of treatment consisted of 8 treatments daily.

After the ecene General condition improved, decrease pain came after the 2nd procedure, pain relief - on the 6th day. Limitation of range of motion in the shoulder joint after treatment - 0-1 points. Complaints to the time of discharge on the 14th day from the start of treatment is not present, pain in the right shoulder joint was missing.

Example 2.

And/b 16247. Patient F., 41, the driver.

Diagnosis at admission: the Upper periastron left, II phase, the acute phase.

The patient was admitted to the hospital complaining of intense pain in the left shoulder joint, aggravated by moving the hands and laying his hands behind his back, limiting the range of motion in the left shoulder joint.

Objective: tenderness to palpation of the left shoulder joint and surrounding tissues, limiting the amplitude of movement - 3 points. On the radiograph: the narrowing of the joint space acromiale-clavicle joint, destructive and bone-traumatic changes it is not revealed.

The course of treatment by the present method was 9 procedures local cryotherapy and therapy neiroimmunnye currents. Assigned to traditional medical therapy: candles Ketonal 2 times daily rectal, tablets Ketonal Forte 100 mg 2 times a day orally, solutions analgin 50% to 4.0 ml, Dimedrol 1% - 2.0 ml, novocaine 0,5% - 10.0 ml, sodium chloride 0,9% - 200.0 ml intravenous drip No. 5, vitamins what s group intramuscularly No. 10. Cryotherapy was performed by using the apparatus "Kryotur 600" (Uniphy Elektromedizin, Germany), grigorovka drove on the skin around the left shoulder joint when the exposure temperature -12°C, the duration of the treatment was 10 minutes. Immediately after cryotherapy was affected neiroimmunnye currents. Used 4-channel device Bioritm-040". The electrodes of the fourth channel is recorded in the left shoulder joint of the cross; the electrodes of the first channel disposed longitudinally in the left paravertebral region at level I-III of the thoracic vertebrae; the electrodes II channel - right paravertebral level I-III of the thoracic vertebrae; the electrodes of the third channel was fixed in the region of the left deltoid muscle. The operation of all channels mixed group, the frequency of the pulse current of the fourth channel is fixed and equal to 100 Hz, the period of migration current on channels 8 sec. The current strength in the fourth channel was increased until the patient is feeling severe vibration under the electrodes in the first to third channels until muscle contractions. The duration of exposure of 10 minutes. The course of treatment was 9 procedures carried out daily.

After treatment the overall condition has improved, decrease pain came after the 1st procedure, pain relief - on the 5th day. Limitation of range of motion in the left shoulder after treatment - -1 points. Complaints to the time of discharge on the 14th day from the start of treatment did not show pain in left shoulder was absent.

Example 3.

And/b No. 19575. Patient C., 50 years, Docker.

Diagnosis at admission: the Upper periastron right, II stage, subacute course.

From the anamnesis it is known that the patient is 5 years old were treated by different methods (medical therapy, laser therapy, electrophoresis of novocaine and other drugs) in the clinic, sanatorium. At admission the patient complained of pain in the right shoulder joint during movement of the hands, radiating to the neck and hand, limitation of range of motion.

Objective: tenderness to palpation of the right shoulder joint and surrounding tissues, limiting the amplitude of motion is 4 points. On the radiograph: katowickie changing structures of the head, right shoulder and acromiale process, narrowing of the joint space acromiale-clavicle joints, osteophytes, subchondral the osteosclerosis, destructive and bone-traumatic changes it is not revealed.

The course of treatment by the present method was 10 local cryotherapy procedures and therapy neiroimmunnye currents on the background of traditional drug therapy: candles Ketonal 2 times daily rectal, tablets Ketonal Forte 100 mg 2 times a day orally, solutions analgin 50% to 4.0 ml, Dimedrol 1% - 2,0 is l, novocaine 0,5% - 10.0 ml, sodium chloride 0,9% - 200.0 ml intravenous drip No. 5, b vitamins intramuscularly No. 10. Cryotherapy was performed by using the apparatus "Kryotur 600" (Uniphy Elektromedizin, Germany), grigorovka drove on the skin around the right shoulder joint, the duration of the treatment was 10 minutes. Immediately after cryotherapy was affected neiroimmunnye currents. Used 4-channel device Bioritm-040". The electrodes of the fourth channel recorded in the area of the right shoulder joint cross; the electrodes of the first channel disposed longitudinally in the right paravertebral region at level I-III of the thoracic vertebrae; the electrodes II channel - left paravertebral level I-III of the thoracic vertebrae; the electrodes of the third channel is recorded in the right deltoid muscle. The operation of all channels mixed group, the frequency of the pulse current of the fourth channel is fixed and equal to 100 Hz, the period of migration current on channels 8 sec. The current strength in the fourth channel was increased until the patient is feeling severe vibration under the electrodes in the first to third channels until muscle contractions. The duration of exposure of 15 minutes. The course of treatment consisted of 10 sessions held daily.

After treatment: Limit range of motion in the shoulder joint - 0-1 points. Decrease pain came after the 1st procedure pain relief - on the 6th day. At discharge after 14 days had no complaints, pain in the right shoulder joint was missing.

Example 4.

And/b No. 18642. Patient T., aged 65, retired.

Diagnosis at admission: the Upper periastron right, II stage, subacute course.

At admission the patient complained of pain and weakness in the right shoulder joint, limitation of range of motion in the shoulder joint.

Objective: tenderness to palpation of the right shoulder joint and surrounding tissues, limiting the amplitude of motion is 2 points. On the radiograph: the narrowing of the joint space acromiale-clavicle joint, destructive and bone-traumatic changes it is not revealed.

The course of treatment by the present method was 10 local cryotherapy procedures and therapy neiroimmunnye currents on the background of traditional drug therapy: candles Ketonal 2 times daily rectal, tablets Ketonal Forte 100 mg 2 times a day orally, solutions analgin 50% to 4.0 ml, Dimedrol 1% - 2.0 ml, novocaine 0,5% - 10.0 ml, sodium chloride 0,9% - 200.0 ml intravenous drip No. 5, b vitamins intramuscularly No. 10. Cryotherapy was performed by using the apparatus "Kryotur 600" (Uniphy Elektromedizin, Germany), grigorovka drove on the skin around the right shoulder when the exposure temperature -6°C, duration of treatment was 5 min is so Immediately after cryotherapy was affected neiroimmunnye currents. Used 4-channel device Bioritm-040". The electrodes of the fourth channel recorded in the area of the right shoulder joint cross; the electrodes of the first channel disposed longitudinally in the right paravertebral region at level I-III of the thoracic vertebrae; the electrodes II channel - left paravertebral level I-III of the thoracic vertebrae; the electrodes of the third channel is recorded in the right deltoid muscle. The operation of all channels mixed group, the frequency of the pulse current of the fourth channel is fixed and equal to 100 Hz, the period of migration current on channels 8 sec. The current strength in the fourth channel was increased until the patient is feeling severe vibration under the electrodes in the first to third channels until muscle contractions. The duration of exposure of 15 minutes. The course of treatment consisted of 10 sessions held daily.

After the treatment, the limitation of range of motion in the shoulder joint - 0-1 points. Decrease pain came after the 2nd procedure, pain relief - on the 7th day.

At discharge after 14 days had no complaints, pain in the right shoulder joint was missing.

The inventive method has been tested in 33 patients (20 patients in the acute stage of upper periarthritis, 13 - subacute stage), ranging in age from 40 to 72 years, 21 mu the rank and 12 women with disease duration from 1 year to 5 years. The clinical picture was typical and was characterized by the presence of pain in the affected shoulder joint, aggravated by moving the hands and laying his hands behind his back, limitation of range of motion in the shoulder joint.

The obtained data were compared with the data described and received when using the prototype method.

The patient group was 8 people (5 patients in the acute stage of upper periarthritis, 3 - subacute stage) aged 50 to 72 years, 5 men, 3 women. Patients received against the standard drug therapy cryotherapy from the setup Cryojet C200 (General and local body cryotherapy. The collection of articles edited by Rev. - Moscow, 2005. - 36 S. - P.20-21).

Patients treated by the present method, the positive trend was clearly expressed. Decrease in pain in the middle came to the 6th - 7th procedure, whereas when using the prototype method - to 8th - 10th procedure.

In 28 out of 33 patients treated by the present method, there was a significant increase in the amplitude of movements, i.e. in 84.8% of cases, while patients treated according to the method-prototype - only 52,0% of cases. Thus, when using the proposed method, a significant increase range of motion in the shoulder joint was noted the and 32.8% of cases, more frequently.

The number of ongoing physiotherapy claimed method of 8-10, and the method prototype - 10-12.

Thus, the claimed method of treatment of patients with humeroscapular periostracum allows comparison with the method of the prototype, in a shorter time to reduce pain, increase range of motion in the shoulder joint and to reduce the number of ongoing physiotherapy, which increases the efficiency of the treatment.

Method of treatment of the humeroscapular periostracum, is the impact of local cryotherapy on the shoulder area, as well as drug exposure, including non-steroidal anti-inflammatory, analgesics and vitamins, characterized in that, in addition to shoulder area immediately after cryotherapy affect neiroimmunnye currents, and local cryotherapy is carried out using apparatus "Kryotur 600", and when the acute phase of upper periostraca cryotherapy is carried out at a temperature of exposure (-6) - (-12)°C, the procedure lasts 8-10 min in the subacute phase of the disease without signs of secondary synovitis cryotherapy is carried out at a temperature (0) - (-6)°C, the duration of the procedure 5-10 min, neiroimmunnye currents affect 4 treatment field, while the electrodes of the fourth channel is fixed in the region of the shoulder joint transversely; the electrodes of the first channel longitudinally in the paravertebral region on the affected side at level I-III of the thoracic vertebrae; the electrodes II channel - paravertebral on the opposite side; the electrodes of the third channel is fixed in the region of the deltoid muscle, the operation mode of all channels mixed group, the frequency of the pulse current of the fourth channel is fixed and equal to 100 Hz, the period of migration current on channels 8, the duration of exposure neiroimmunnye currents 10-15 min, the treatment course of 8-10 treatments daily.



 

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SUBSTANCE: invention relates to novel compounds of formula I, which are HSP90 (heat-shock proteins) inhibitors and can be used to prepare a medicinal agent for treating tumorous diseases affected by HSP90 inhibition. In formula I R1 denotes Hal, H, OA or A, R2, R3 each independently denotes -O-(X)s-Q, -NHCO-(X)s-Q, -CONH-(X)s-Q, -NH(CO)NH-(X)s-Q, -NH(CO)O-(X)s-Q, -NHSOr(X)s-Q, NHCOA, Hal, Het or H, where, if R2=H, then R3≠H, or if R3=H, then R2≠H, R4 denotes H, R5 denotes H, Hal, A, OA, (CH2)nCOOH, (CH2)nCOOA, O(CH2)oCONH2, NHCOOA, NHCO(CH2)nNH2, NHCONHA or O(CH2)oHet1, A denotes a straight or branched alkyl containing 1-10 carbon atoms, in which 1-5 hydrogen atoms may be substituted with F, Cl and/or Br, X denotes a straight or branched C1-C10 alkylene which is unsubstituted or substituted once, twice or thrice by A, O A, OH, Hal, CN, COOH, COOA, CONH2, NH2, NHCOA, NHCOOA, Q denotes H, Ar or Het, Ar denotes phenyl which is unsubstituted or substituted once, twice or thrice with A, OA, OH, NO2, Hal, CN, (CH2)nCOOH, (CH2)nCOOA and/or tetrazole, Het denotes a cyclic saturated or aromatic 5-6-member heterocycle containing 1-2 N and/or O atoms, optionally condensed with a benzene ring which may be substituted once, twice or thrice with A, OA, OH and/or =O (carbonyl oxygen), Het1 denotes a monocyclic saturated, unsaturated or aromatic heterocycle containing 1-2 N and/or O atoms, which may be mono- or disubstituted with A, OA, OH, Hal and/or =O (carbonyl oxygen), Hal denotes F, Cl, Br or I, n equals , 1, 2, 3 or 4, o equals 1, 2 or 3, s equals 0, 1 or 2.

EFFECT: high efficiency of using said derivatives.

4 cl, 4 dwg, 1 tbl, 29 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely - to neurology, vertebrology and restorative medicine. The method involves drug-induced analgetic blockade. The blockage is combined with interstitial carpain electrophoresis of an anaesthetic injection place. Current intensity for electrophoresis is 4-7 mA. Duration of a procedure is 10-12 minutes. The procedures are daily; the therapeutic course is 12-15 procedures.

EFFECT: method provides managing pain syndrome, reducing the volume of hernial bulge, restoring radicular conductivity, increasing duration of remission.

1 ex, 3 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, namely to arthrology, rheumatology, and can be used for treating rheumatoid arthritis. That is ensured by introducing human CD20 specific small modular immune-pharmaceutical (SMIP) protein in a therapeutically effective amount to the patient. The introduction is single, and the supporting treatment is not performed for approximately three months to two years after the introduction of a first single dose.

EFFECT: single introduction provides almost complete B-cell elimination and considerable prolonged rheumatoid factor level reduction in said category of patients.

24 cl, 4 tbl, 8 ex, 5 dwg

FIELD: medicine; electric engineering.

SUBSTANCE: method and device for generation of electric signal to be used in bio-medical applications has two time-presetting units 92, 94 for generation of time intervals T1-T7, unit 96 for combining mentioned intervals into output signal, which has predefined relation between intervals, output unit 104 for transmitting output signal to load, filter 102 for removing undesired frequency components and tuning unit 100 to select output signals from set of signals, which output signals have predetermined characteristics. Output signal has to be repeating sequence of rectangular pulse packages, equalizing impulse (if necessary) to eliminate constant shift in case when it is undesirable, and rest period with absent signal. In case when permanent shift is required, it is possible to neglect equalizing pulse. In this case the rest signal includes superimposed permanent potential.

EFFECT: widened area of application; wider area of application; higher rate of wound healing; better pain relief.

68 cl, 18 dwg, 2 tbl

FIELD: medicine.

SUBSTANCE: method involves additionally applying 20% rock balsam solution as applications on tongue on the background medicinal therapy. Then, device is applied to treat painful zones of tongue in constant intensity. The total treatment course is 6-8 days long.

EFFECT: accelerated treatment course; prolonged remission period.

FIELD: medicine; physiotherapy.

SUBSTANCE: device can be used for treating osteochondrosis, muscular injuries and other diseases. Device for anesthetization during sleep has contact detectors connected with current pulse sequence oscillator, which is connected with control unit. Device additionally has band-pass amplifier, square detector and integrator. Control input of control unit is connected with output of comparator which has output connected with output of band-pass amplifier through integrator and square detector. Band-pass filter is adjusted to frequency of alpha rhythm of brain's potentials. Input of band-pass amplifier is connected with devices for receiving those potentials. Physiotherapeutic devices are turned on under influence of alpha rhythms of brain on the threshold of awakening.

EFFECT: improved efficiency of influence due to automatic switching-on.

1 dwg

FIELD: medical equipment.

SUBSTANCE: apparatus for electric tranquilization has unit for rhythmical influence to central nervous system by current pulses, power unit electrically connected with unit for rhythmical influence, pulse influence intensity control unit, current pulse preamplifier and power amplifier. Input of power amplifier is connected to output of pulse preamplifier. One of output of power amplifier is connected with preamplifier through unit for protecting patient against increase of average current higher than admissible one. The other output is electrically connected with average current value indicator. Apparatus also has anode disposed at areas of mammiform appendices of patient's head. Cathode is disposed at forehead of patient. Unit for combined protection of patient and apparatus against influence of discharge of capacitive component of patient's skin impedance is provided at points of electrodes application and against environmental influence to hardware members of apparatus inform of static electricity, high frequency currents and electric and magnetic fields. One input of unit is connected with output of power amplifier; the other one is connected with average current value indicator. One output of the unit is connected with anode and the other one - with cathode. Unit for electric tranquilization has at least two apparatuses having different current pulse repetition frequencies. Each apparatus has unit for combined protection of patient and apparatus.

EFFECT: better quality of protection of patient and apparatus; increased intensity of pulse influence.

5 cl, 6 dwg

FIELD: medicine, applicable for stopping of pains of various nature.

SUBSTANCE: the device has a quantum-mechanical oscillator located in a casing, magnet, vessel for medicinal agent and a hollow cylinder. The magnet is installed between the oscillator and the vessel. Positioned in the vessel is a hollow cylinder having through holes on its surface.

EFFECT: quick and absolute anestesia.

2 ex, 1 dwg

Electrolyzer // 2240841
The invention relates to the field of medicine, particularly acupuncture, and can be used to find points of acupuncture (TA), assessment of their functional status and treatment of diseases using electroacupuncture

The invention relates to physiotherapy and can be used to stimulate endorphin mechanisms of the brain

The invention relates to medicine, namely to dentistry
The invention relates to medicine, neurology

The invention relates to the field of medicine and medical equipment and can be used for the treatment of diseases based on the pathogenesis of which is the formation of stagnant pockets of excitation or inhibition in the cortex of the cerebral hemispheres, and can be used for the treatment of nervous and mental diseases, psychosomatic diseases, removal of reactive States, as well as in drug for the treatment of various addictions, such as food, alcohol, drugs, drugs, tobacco, etc

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of pharmaceutical and food industry, in particular to production of vitamin-mineral complexes (VMC) and food additives, used for prevention and treatment of vitamin-mineral deficiency. Simultaneously, taken into account are all antagonistic and synergic interactions between active VMC components, arising in production, storage and application of medication. Delivery of micronutrients by time and place of their digestion is realised within one preparative form, which is made in form of tablet or capsule, containing several independent elements - pellets. Pellets have their time of dissolution, depending on acidity of surrounding medium. During movement of ready form along GIT time of beginning of substances release from one pellet follows time of end of substances release from other pellet in such a way that simultaneously in solution there were no active substances that have antagonistic interaction.

EFFECT: invention is aimed at increase of VMC efficiency and improvement of user's comfort during its application.

23 cl, 10 ex, 2 tbl

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