Device for continuous countercurrent chromatography

FIELD: physics.

SUBSTANCE: device (1) for continuous countercurrent chromatography has several rotating chambers (2, A, B, C) placed around an axis of rotation (D), said chambers being configured to contain the liquid or mixture of liquids under investigation. Separate chambers are connected through liquid-conducting connections (3) such that two liquids flow in opposite directions. One of the liquids first passes through several chambers and then returns to the first chambers in the direction of flow. The mixture of liquids is also fed into chambers (A, B, C) from sides (22) of chambers (B, C, A) lying near the axis of rotation, after coming out of neighbouring chambers (A, B, C) opposite the direction of rotation from the side (21) which is far from the axis of rotation.

EFFECT: high efficiency of separation in continuous mode, and high efficiency of complete mixing and subsequent phase separation.

13 cl, 3 dwg

 

The invention relates to a device for the continuous countercurrent chromatography, intended for the separation and/or purification of substances in accordance with the principle of separation "liquid-liquid".

The principle of the separation liquid-liquid", known for many years, but the implementation consists of a periodic process, which can be downloaded only a small amount of sample. The following number of sample can be loaded only after the complete processing of the previous sample. Such a device is known from WO 2004/079363 And where the phase is directed through multiple rotating cameras located around the perimeter of the cylinder.

The aim of the present invention is to provide an improved in comparison with the prototype device for chromatography, which allows for efficient, continuous mode to separate materials.

The specified objective is achieved through the device for continuous countercurrent chromatography in accordance with the characteristics of paragraph 1 of the claims.

In the present invention, an apparatus for continuous countercurrent chromatography with multiple rotating cameras placed around the axis of rotation, and camera adapted for containing the investigated liquid or mixture of liquids, and individual cells are interconnected through the conductive fluid connections so the two liquids were sent to the counter, where one fluid is first passed through several chambers, and then back to the previous camera to create a parallel stream.

The proposed device for the continuous countercurrent chromatography is characterized by the fact that it shows good separation efficiency and good performance to effectively complete mixing and subsequent separation of the phases.

Add in the liquid sample material is optimally distributed between them depending on solubility. The sample material can also be a mixture of different substances. Compared with the prototype of the specified device for the first time allows partially recirculating the sample during the process.

In one of the most preferred variants of the invention it is proposed that the fluid mixture is served in the camera with their hand, which is located closer to the axis of rotation, after the release of the mixture from the neighboring against the direction of rotation of the camera with her hand, more remote from the rotation axis.

Still one of the most preferred variants of the invention it is proposed that the fluid mixture is served in the chamber of the first group, more remote from the axis of rotation, after the release of a mixture of the following in the second direction of rotation of the camera with her hand, closer Kosi rotation.

In another most preferred embodiment of the invention proposed that the fluid mixture is served in the chamber of the second group, more remote from the axis of rotation, after the release of the mixture from the neighboring against the direction of rotation of the camera with her hand, located closer to the rotation axis.

Preferably, each of the output and input channels of the camera is located radially.

In an additional embodiment, the present invention provides that the two liquids or mixtures of liquids, consist, on the one hand, from the heavy phase, and on the other hand, of the light phase.

The camera preferably interconnected in a continuous ring.

Preferably, each of the two liquids are served in an interconnected chambers through the corresponding input and output of these cameras through the corresponding output.

In the following a preferred embodiment of the invention it is proposed that the material sample is served between pairs of these inputs and outputs in a different point in the sequence of interconnected chambers.

In one embodiment, suggested that mixtures of liquids are immiscible.

Liquid or mixture of liquids is preferably a solvent or mixture of solvents for the sample material.

In the most effective design solution is proposed that the cameras are located around the circumference.

Cameras which are preferably of identical design.

In more detail, the invention is described below using the drawings.

Figure 1 presents a schematic top view of a device for the continuous countercurrent chromatography according to the present invention;

figure 2 - schematic representation of examples of three chambers with the images in them to explain the flow;

figure 3 - schematic representation of the phase separation in the three cells shown in figure 2, which is achieved in the direction of the camera positions from left to right.

The same item numbers in the drawings indicate identical or identically acting elements.

Figure 1 schematically shows a device 1 for continuous countercurrent chromatography according to the present invention with multiple cameras 2, placed around the axis of rotation D and the rotating direction R. Chambers are interconnected through conductive fluid connections 3.

The analyzed fluid or fluid mixture moves through the interconnected chambers 2.

After passing through the several chambers of the fluid through the system connection is returned to the flow in the previous chamber, which is formed parallel to the stream.

Camera 2 is placed around the circumference of the fastening plate 4, which rotates around the axis of rotation D, and the camera 2 are interconnected through connections 3 in complianc is a great ring.

Each of the output 23 input 24 camera channels is located radially relative to the axis of rotation D.

In the area of the break ring U two fluid continuously served in an interconnected chambers through the respective inputs 31, 33, and separated liquids are removed from the chambers through the respective outputs 32, 34.

The fluid or fluid mixture is a solvent for the material of the sample. Last through the loading channel 35 serves in an interconnected chamber 2 forming the sequence between pairs of these inputs 31, 33, and outputs 32, 34.

Figure 2 illustrates schematically the flow of fluid. The fluid mixture is served in the chambers a, b, C by 22 cameras In, With, And located nearer to the axis of rotation, after exiting from adjacent the rotational direction of the cameras a, b, C from 21, more remote from the rotation axis.

The fluid mixture is served in the camera And, In the first side 21, a more remote from the axis of rotation, after the release of the next second in the direction of rotation of the camera, And on her part 22 located closer to the rotation axis.

The fluid mixture is served in the camera (the second group) from 21, more remote from the axis of rotation, after exiting from adjacent the rotational direction of the camera 22, lying closer to the axis of rotation.

Two liquids or mixtures of liquids, consist, on the one hand, from the heavy phase, and on the another hand, of the light phase. This improves the separation of the sample material.

Phase L is fed into the chamber And through the connecting element A7, in the camera - through connection elements A2 and B9 in the camera - through connectors C4 and C11.

Then the phase of L via the connecting element C6 is served to the connecting element A7 camera And in the next to the right block other cameras a, b, C (not shown).

The S phase is fed through a corresponding connecting element A8 from the camera And the adjacent block (not shown) in the camera through the connecting element B3.

Through the connecting elements 10 and C5 phase S is fed into the chamber c of the connecting element C11 and forth through the connecting elements C12 and A1 in the chamber A. the Next phase S is fed through a coupling element A8 to the connecting element B3 of the camera In the left block (not shown).

Several interrelated cameras allow you to move two almost not miscible fluids in counterflow. In the cells of the phase is completely mixed, so the sample material is distributed in the respective phases, depending on its solubility. This device uses the principle of spherical separating funnel and the Nernst distribution.

Forced rotation creates in the chambers of the centrifugal force, resulting in the separation of the phases in the same chamber, so that sledujushchemu phase may be sent separately.

Since fast full mixing and separation and, therefore, the specified move, respectively, net of phases L and S can not be implemented in the contraflow in each cell phase is directed transversely to each other. These cells are grouped into blocks (e.g., camera a, b, C) by means of a special set of compounds, and these blocks phase are moved in parallel. A counter-current process is achieved by the arrangement of connections between the individual blocks.

Figure 3 schematically shows the result of phase separation, which is achieved in the direction of the camera positions from left to right.

1. The device (1) for continuous countercurrent chromatography, containing several placed around the axis of rotation (D) rotating chambers (2, a, b, C)adapted for containing the investigated liquid or mixture of liquids, and individual cells are interconnected through conductive fluid connection (3) so that the two liquids were sent to the counter, where one fluid is first passed through several chambers, and then back to the original passed in the flow direction of the camera.

2. The device according to claim 1, characterized in that the fluid mixture is served in the camera (a, b, C) from (22) of the camera (In, With, And located closer to the axis of rotation, after the release of the mixture from the neighboring in the direction of rotation of the camera (And, B, C) from (21), more remote from the rotation axis.

3. The device according to claim 1 or 2, characterized in that the fluid mixture is served in the camera (a, b) of the first group on their part (21), more remote from the axis of rotation, after the release of a mixture of the following in the second direction of rotation of the camera (S, A) with sides (22), located closer to the rotation axis.

4. The device according to claim 1, characterized in that the fluid mixture is served in the camera (C) of the second group on their part (21), more remote from the axis of rotation, after the release of the mixture from adjacent the rotational direction of the camera (In) on her part (22)that is located closer to the rotation axis.

5. The device according to claim 1, characterized in that each of the output (23) and the input (24) of the TV camera (2) is located radially relative to the axis of rotation (D).

6. The device according to claim 1, characterized in that the two liquids or mixtures of liquids, consist, on the one hand, from the heavy phase, and on the other hand, of the light phase.

7. The device according to claim 1, characterized in that the chamber (2) are interconnected in a continuous ring.

8. The device according to claim 1, characterized in that the two fluid continuously served in an interconnected chamber (2) through the appropriate inputs (31, 33) and output of these cameras (2) through the respective outputs (32, 34).

9. The device according to claim 8, characterized in that the material of the sample served between pairs of these inputs and outputs in another aspect, also the e sequence of interconnected chambers (2).

10. The device according to claim 1, characterized in that the liquids are immiscible.

11. The device according to claim 9 or 10, characterized in that the liquid or mixture of liquids consists of a solvent or mixture of solvents for the sample material.

12. The device according to claim 1, characterized in that the camera (2) is placed around the circumference.

13. The device according to claim 1, characterized in that the cells have the same design.



 

Same patents:

FIELD: physics.

SUBSTANCE: device (1) for continuous countercurrent chromatography has several rotating chambers (2, A, B, C) placed around an axis of rotation (D), said chambers being configured to contain the liquid or mixture of liquids under investigation. Separate chambers are connected through liquid-conducting connections (3) such that two liquids flow in opposite directions. One of the liquids first passes through several chambers and then returns to the first chambers in the direction of flow. The mixture of liquids is also fed into chambers (A, B, C) from sides (22) of chambers (B, C, A) lying near the axis of rotation, after coming out of neighbouring chambers (A, B, C) opposite the direction of rotation from the side (21) which is far from the axis of rotation.

EFFECT: high efficiency of separation in continuous mode, and high efficiency of complete mixing and subsequent phase separation.

13 cl, 3 dwg

FIELD: process engineering.

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EFFECT: optimised amounts of components, higher efficiency.

15 cl, 13 dwg, 2 ex

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