Medication for treatment of patients with drug hepatitis

FIELD: medicine.

SUBSTANCE: invention relates to field of pharmacy, in particular to phytotherapy, and can be applied for treatment of drug hepatitis. Medication represents herbal mixture, including 29 herbs: herbal part of woodland strawberry, herbal part of common dandelion, inflorescences of pineapple weed, leaves of stinging nettle, inflorescences of tansy, inflorescences of pot marigold, fruits of common juniper, peppermint leaves, herbal part of St John's wort. Medication additionally contains: lime tree flowers, herbal part of heartsease, herbal part of Centaurium, flax seeds, dill seeds, burdock root, herbal part of common chicory, herbal part of common knotgrass, collective fruits of common hop, herbal part of cornflower, leaves of cowberries, leaves of Arctostaphylus, corn stigma, herbal part of immortelle, root and rhizome of Acorus, herbal part of Menyanthes, garden angelica root, herbal part of yellow sweet clover, Inula root, herbal part of common horsetail.

EFFECT: mixture reduces terms of hepatitis treatment, as well as improves clinico-laboratory indices due to normalisation of liver function tests and functional state of liver.

4 ex, 2 tbl

 

The invention relates to the field of pharmacy, in particular herbal medicine and can be used for the treatment of drug-induced hepatitis.

Currently, one of the most used drugs in medicine are antimicrobial drugs. These include antibiotics, sulfonamides, metronidazole, various anti-TB and anti-virus tools. They all have different degrees of allergic and toxic side properties and when used in clinical doses can cause skin rashes, fever, anaphylaxis, thrombocytopenia, neutropenia, nausea, vomiting, convulsions and toxic effects on the function of the liver, resulting in increased level of AST and bilirubin.

The use of combined preparations of penicillin and In-lactams may cause cholestatic hepatitis, and in some cases jaundice (Sanford D.ZH., Gilbert D., Gerberding D.ZH., Sande M. antimicrobial therapy M., 1996, p.88-89).

Long-term use of nitrofurantoin leads to the intrahepatic cholestasis and chronic hepatitis (Sanford D.ZH., Gilbert D., Gerberding D.ZH., Sande M. antimicrobial therapy. M., 1996, pp. 102).

When applying anti-tuberculosis drug isoniazid often occurs hepatitis, exacerbated by alcohol use that in the future, in some cases the x, can lead to a fatal outcome (Sanford D.ZH., Gilbert D., Gerberding D.ZH., Sande M. antimicrobial therapy. M., 1996, s).

Pyrazinamid in some cases leads to the development of hepatitis (Treatment of tuberculosis. Guidelines for national programmes. Geneva, 1994, ñ.38).

Excessive intake of vitamin A (20000-40000 units/day) for several years can cause cholestatic liver disease. Vitamin a is deposited in the liver cells. Further, the increased level of bilirubin, serum and alkaline phosphatase (Therapy. Ed. Myers, A.R., M., 1998, s).

For the treatment of AIDS in adults applies zidovudine, which may contribute to the development of fatty liver (Therapy. Ed. Myers, A.R., M., 1998, p.148).

One of the most toxic drugs is acetaminophen (paracetamol), which is used as an analgesic and antipyretic, but long-term use can manifest its hepatotoxic effects (Mashkovsky PPM Medicines. M., 2005, s).

Tricyclic antidepressants or Central a-adrenergic blockers may lead to the development of acute and chronic hepatitis with cytolysis, cholestasis and granulomatosis lesions (Disease of the liver and biliary tract. Ed. Ivashkin V.T., M., 2002, p.123). The drug methyldopa, often used in terap ticheskoj practice, often leads to impaired liver function, jaundice and cholestasis (Mashkovsky PPM Medicines. M., 2005, s).

It is known that steroids with long-term use can cause changes in liver function and lead to cholestasis. When using combined oral contraceptives (COCS) can increase the amount of conjugated bilirubin and appear cholestatic jaundice. Approximately 10-20% of women taking COCS, there is an increase in cholesterol and increases the frequency of gallstone disease (Hormonal contraception and thrombophilic disorders. Under. edit Manicaria A.D. and Sadovoy R.A., M., 2004, p.55).

The most common reason for the development of liver dysfunction and the occurrence of drug-induced hepatitis are anabolic steroids, halogenated anaesthetics, sulfonamides and valproic acid and its derivatives (Marini Did Wheeler A.P. Medicine critical States. M., 2002, s).

It is possible to capture these regularities in the development of drug-induced hepatitis: some drugs in clinical doses can cause liver damage. A significant portion of drug overdose leads to the development of drug-induced hepatitis, and almost all drugs, if their use is accompanied by alcohol, can cause the development of medicamento the cases of hepatitis.

The liver and kidneys are the main organs involved in metabolism and deducing medicinal substance. In chronic hepatic clearance of drugs can be broken, so it is better to use medicines which are not subjected to intensive metabolism and excretion in the liver (Therapeutic guide the University of Washington. Ed. Woodley via M. and Whelan, A. M., 1995, s-423). Herbal meet all these requirements.

Treatment of chronic liver disease support, the main component is a low - calorie diet (no more than 2500-3000 kcal), enriched with b vitamins, especially thiamin and palataki. However, high doses of corticosteroids, azathioprine or a combination thereof effective in chronic hepatitis due to immune mechanisms, but usually unsuccessful in diseases of medicinal and viral origins (therapy. Ed. Myers, A.R., M., 1998, str-305).

Very often for the treatment of chronic liver diseases arising on a background of application of various drugs used hepatoprotective drugs: Essentiale, legalon, citrate betamin, as well as vitamins of the various groups.

For the treatment of chronic alcoholic hepatitis drug applied hofitol obtained from an extract of the fresh leaves of the artichoke. Hofitol has a direct effect on the PE the Yan and kidneys, as well as on other organs and systems of the body. At the same time, the drug improves the antitoxic function of the liver increases production of coenzymes hepatocytes, affects the metabolism of lipids and cholesterol (Loranca I.D., Rakitskaya G. Mamedov L.D. Russian journal of gastroenterology, Hepatology, Coloproctology. 2005, No. 3, s). However, this drug has a mild clinical effects and are not effective in the treatment of drug-induced hepatitis.

Sometimes for the treatment of liver diseases is applied hepatoprotective collection # 1: grass immortelle sandy (part 1), knotweed (1 h), grass, milk Thistle (1 h), agrimonia (1 h), grass cuff ordinary (1 h), rosehips and cinnamon (1 tsp) tablespoon of the mixture should pour 1 Cup of boiling water for 3-6 hours in a thermos, drain. Use 1/3-1/2 Cup three times a day for 20-30 minutes before meals (Ivanchenko VA Natural medicine. M., 2004, s).

However, this collection does not have a pronounced therapeutic effect due to insufficient choleretic effect, and with long-term use possible side effects, milk Thistle on the heart. In addition, the collection is in thermos 3-6 hours, which reduces the effect of certain active substances in medicinal raw materials.

Also used hepatoprotective collection No. 2: ground roots and rhizomes of Valerian large - 1 o'clock, grass caps drug - 1 PM; grass procrastina - 1 PM; grass common plantain - 2 hours; grass cuff - 1 h; the crushed roots of Bupleurum - 1 h; the fruit of the barberry - 1 PM; herb chicory ordinary - 1 PM; grass celandine - 1 h; the roots of the licorice - 1 tsp tablespoon of the mixture should pour 1/5 of a Cup of water, boil for 10 minutes, to insist 1 hour, to cool. Use 1/3-1/2 Cup three times a day before meals (V.N. Ivanchenko. Natural medicine. M., 2004, s).

However, this fee is not recommended in patients with high acidity of gastric juice due to the relatively high content of plantain, grass - 2 parts. In addition, some patients are not excluded toxic reaction to the herb celandine - 1 p.m.

For the treatment of chronic hepatitis, you can use tea from the following collection: herb Hypericum perforatum - 40,0 g, herb - 20,0 g, grass wild chicory - 30.0 g, immortelle flowers sand - 40,0 g, chamomile flowers pharmacy - 10,0 g, buckthorn bark - 30.0 g, marigold flowers - 40,0 g 20,0 g of the mixture in the evening, pour 400 ml of raw water, leave overnight, in the morning boil for 5-7 minutes, to insist 20 minutes to eat during the day (Lavrenov, GV Medicinal herbs. M., 1996, CN, s-368).

This fee is not quite pronounced clinical effect in the treatment of drug g is patito due to the relatively high content of sand immortelle - 40,0 g, and it is impractical to patients with hyperacid gastritis and chronic colitis due to the high content of buckthorn bark.

Sometimes for the treatment of chronic hepatitis applies to the collection, consisting of fruit of the barberry, birch leaves, leaves of walnut, grass thistles curly, herb St. John's wort, yarrow on 10,0, the infusion is Prepared from one table of a mixture of 1 tbsp. of boiling water per day to drink the infusion 2-3 times (Yordanov D., Nikolov P., Bostanov A. Herbal medicine. Sofia, 1968, s-310).

But this collection does not have a fairly pronounced clinical effect, and also because of the relatively high content of yarrow cannot be applied to patients with high acidity. In addition, the use of grass thistles curly contraindicated in kidney disease.

The prototype of the present invention is a fee applied for the treatment of hepatitis and consisting of 14 species of medicinal plants: buckthorn bark olhovidnoy 20,0 g; herb Polygonum pepper 20,0 g; grass strawberry 20,0 g, herbs Bupleurum aureum 20,0 g; grass lnjanki ordinary 20,0 g; herbs dandelion 20,0 g; leaf nettle 20,0 g; inflorescence tansy 20,0, chamomile flowers bezyazykove; inflorescences calendula 10.0 g; juniper berries ordinary 10.0 g; the East peppermint 10,0 g; herbs Hypericum perforatum 10,0 g; grass celandine 10,0,

One tablespoon of the mixture brew 0,5 l of boiled water, to insist 30 minutes, strain and drink per day in three doses for 10-15 minutes before eating (Rylkov M.I., Shekotova A.P., Gogoleva M.A., Than we are treated. Perm, 1995, k.2, 164).

But this collection does not have a strong detoxifying effect in the treatment of drug-induced hepatitis. In addition, due to the high content of buckthorn bark (20,0) it cannot be prescribed to patients with high acidity of gastric juice and chronic colitis. In addition, the relatively high content of tansy (20,0) not contribute to the restoration of the detoxifying function of the liver. Greater celandine (10,0) may cause some patients have nausea and vomiting.

The technical result achieved by the invention consists in enhancing the detoxifying action of drug collection, manifested in the normalization of the functional state of the liver, and reduction of terms of treatment of patients with drug-induced hepatitis.

The technical result is achieved by the fact that the tool is an herbal blend that includes: grass, wild strawberry, the grass dandelion, chamomile flowers bezyazykove, leaf of nettle, inflorescence tansy, florets of calendula, the fruit of juniper, obyknovenny the th, peppermint leaves, grass Hypericum perforatum, characterized in that it further comprises lime flowers, grass tricolor violet, herb centaury, flax seed, dill seed, burdock root, herb, chicory ordinary, grass knotweed, stems hop ordinary, grass, cornflower blue, bilberry leaf, bearberry leaf, corn stigmas, grass immortelle, roots and rhizomes of calamus, the grass watch three leaf, Angelica root, grass clover medicinal, elecampane root, horsetail grass, and at the next mass ratio of components:

The wild strawberry, the grass - 5-7

The dandelion, grass - 4-6

Daisy bezyazykove, inflorescence - 10-12

Stinging nettle leaf - 6-8

Common tansy, racemes 2-4

Calendula officinalis, racemes 1-3

Juniperus communis fruit - 5-7

Peppermint, leaves - 8-10

St. John's wort, a grass - 9-11

Linden flowers are about 20-22

Viola tricolor, grass - 19-21

Centaury, grass - 6-8

Seed flax 10-12

Seed dill - 9-11

Burdock root - 4-6

Endive ordinary grass - 7-9

Knotweed, grass - 6-8

Hops ordinary stems - 8-10

Cornflower blue, grass - 3-5

Cranberries, the sheet - 6-8

Bearberry leaf - 3-5

Corn stigmas - 7-9

Immortelle, grass - 4-6

Air, roots and rhizomes - 5-7

Watch three istna, grass - 7-9

Angelica root - 7-9

The clover medicinal, herb - 8-10

Elecampane root - 7-9

Horsetail grass is 6-8.

Grass strawberry has anti-inflammatory, disinfectant, regeneration and choleretic action. It increases bile secretion from the liver ducts and gall bladder, reduces inflammation in the biliary tract, promotes the excretion of salt and sand from the bile ducts and gall bladder, as well as normalizes the function of the pancreas.

Grass dandelion can be choleretic effect, amplifying secretion of gastric juice and pancreatic cancer. Has antispasmodic and laxative properties, normalizes the composition and flow of bile, increases diuresis, promotes and improves the yield of liquid through the intestines, stimulates the appetite, affecting food center.

Chamomile flowers bezyazykove can be anti-inflammatory, antimicrobial and antiviral properties, to show choleretic effect, to promote the release of bile from the liver passes, to improve choleris, to normalize the viscosity of bile, reduces inflammation in the liver.

The leaf of nettle stimulates liver function, improves carbohydrate and protein metabolism, has anti-inflammatory and choleretic action, thereby improves choleras p and stagnant and toxic hepatitis, accelerates regeneration processes in the liver, stimulates the release of bile from the gall bladder, and also restores the body's resistance to the effects of different factors external and internal environment.

Inflorescences tansy cause antibacterial, anti-inflammatory, antihelminthic effects, enhance the secretion of bile in the liver and is released from the liver passages, and reduce it to the amount of mucus. Tone the muscles of the intestinal tract and enhance the secretion and inhibit bacteriological flora.

Florets of calendula have anti-inflammatory effect, increased secretory activity, increase bile formation and biliary excretion, activate the processes of regeneration in the liver. Due to high content in flowers of calendula carotinoids, flavanoids, ascorbic acid and organic acids cause they increase the metabolic functions of the liver, improve the composition of bile, increases secretory and excretory function of the liver.

The fruits of Juniperus communis l have a diuretic effect, increase bile formation and biliary excretion, holocaut the secretion of gastric juice, increase peristalsis. They also have antibacterial and anti-inflammatory properties, as well as contribute to reduced the Yu stagnation of bile in the hepatic ducts and the gall bladder.

Peppermint leaves can cause a calming, antispasmodic, analgesic and choleretic effects. Enhance the secretion of digestive glands, increases bile secretion, normalize the viscosity of bile and promote regeneration of liver cells.

The herb St. John's wort herb has astringent, anti-inflammatory and antimicrobial properties. Provides capillary action, improves venous circulation and blood flow to internal organs. The herb has antispasmodic effect on the smooth muscles of the bile ducts, increases the flow of bile from the liver, prevents stagnation of bile in the gall bladder, reduces functional failure renal glomeruli, promotes the secretion of fluid and electrolytes from the body. St. John's wort possesses antimicrobial activity against some microorganisms that are resistant to antibiotics.

Linden flowers have antimicrobial, anti-inflammatory and anti-edematous action, have a calming effect. In addition, lime flowers help to increase choleresis and facilitate the flow of bile into the duodenum, stimulates the secretion of gastric juice, increase diuresis, increase the exocrine function of the pancreas.

Grass tricolor violet has protivovospalitel is inoe, spasmolytic, choleretic and diuretic actions, the active component of the herb violet is flavonovy glycoside volkmarsen that when local and resorptive action promotes the densification of cell membranes, inhibits the absorption of various substances inflamed tissues.

Herb centaury stimulates the secretion of digestive glands, helps to normalize choleresis, and also normalizes the motor function of the gallbladder, and improves the secretion of pancreatic juice. It promotes the excretion of toxins from the liver and intestines, and restores the General condition of the patient after long-term chronic diseases.

The flax seed has anti-inflammatory, enveloping and minor analgesic properties. When intake per os flax seeds are covered with a thin layer of mucous membrane of stomach and duodenal ulcers, preventing irritation. Under the influence of the enveloping means decreases the absorption of intestinal infectious toxins that can cause the phenomenon of intoxication of the organism.

The dill seed has anti-inflammatory, antiseptic, diuretic, expectorant, diuretic and carminative properties. Fennel seeds can be used to treat diseases of the liver and biliary tract because they stimulate the excretion of bile from the liver and gallbladder, and also contribute to the release of sand and small stones from the gall bladder, kidneys and urinary bladder.

Burdock root has diuretic, diaphoretic and choleretic action, it improves the flow of bile from the liver passages and gall bladder, and also stimulates the formation of pancreatic enzymes. Providing antimicrobial, antiseptic and anti-allergic effects, it reduces inflammation in the liver passages, thereby normalizing liver function.

Herb chicory ordinary has antimicrobial, anti-inflammatory, choleretic, diuretic and sedative properties. It has a regulating effect on the metabolism, normalizes choleras for chronic hepatitis, reduces inflammation of the mucous membrane of the stomach and intestines, and also improves the detoxifying activity of the liver.

Grass knotweed has antimicrobial, anti-inflammatory and astringent properties. It has anti-toxic effect and demonstrates a positive effect on functional liver failure caused by delay in the body of various toxic products of metabolism or from outside.

Stems hop ordinary provide anti-inflammatory, capillary, hyposensitizing antimicrobial and choleretic action. About the and regulate mineral metabolism, restore choleris, liquefies the bile in the gall bladder and normalize detoxifying function of the liver.

Cornflower blue, possess anti-inflammatory, disinfectant, antispasmodic, diaphoretic, astringent, diuretic and tonic properties. Herbal medicines flowers of cornflower blue also possess diuretic properties, which are caused in them anicinabe. Bitterness present in the plant, improve digestive functions.

The leaves of cowberry has an antiseptic, diuretic, choleretic, antiseptic, antibacterial and anti-inflammatory effect. The positive effect is due to the ability of a cowberry leaf to reduce the permeability and fragility of capillaries of the liver.

Bearberry common causes diuretic and antibacterial action, it also has a choleretic and antispasmodic effect, a positive effect on the vessels of the terminal vascular beds and stimulates regeneration of liver cells. Due to its disinfectant properties, it reduces inflammation in the biliary tract and partially gall bladder.

Corn silk can cause marked choleretic effect, regulating the secretion of bile from the gall bladder and the outflow of pancreatic juice. They help stop nausea and vomiting, and also speeds up the t blood clotting.

Immortelle flowers sand have anti-inflammatory, antibacterial, inflammatory and choleretic action. They stimulate the secretion of gastric juice and activate the secretory capacity of the pancreas, has antispasmodic effects on the blood vessels, helping to improve circulation of the stomach and duodenum.

The roots and rhizomes of calamus are able to exert anti-inflammatory, bacteriostatic, fungistatic and antispasmodic actions. They improve digestion in the stomach, increase the tone of the gall bladder, strengthen the excretory function of the liver.

Leaves watch three leaf has anti-inflammatory and soothing action, stimulate the secretion of bile from the liver and is released from the gall bladder. They also have antiseptic and antipyretic actions, promote the excretion of toxic products from the liver, thereby improve and normalize its function. Leaves watch three leaf also increase the tone of the whole organism.

The roots of Angelica have anti-inflammatory, antispasmodic and bactericidal properties. They increase bile excretion from the liver and contribute to the normalization of the outflow of bile from the gallbladder, thin the bile and promotes its exit into the duodenum, as well as Wuxi is more of the secretion of pancreatic juice. In addition, they increase sweating and diuresis, thereby helping to eliminate various toxins from the liver, and improve the function of hepatocytes.

Grass clover drug has a strong detoxifying properties, increases the phagocytic activity of leukocytes, improves peripheral blood flow to the tissues of the liver, exhibits antibacterial properties, improves liver function, strengthens haeres.

The roots of elecampane possess expectorant, anti-inflammatory, cholagogue, diaphoretic properties, stimulate metabolism. The roots of Valerian is effective in diseases of the liver and gall bladder, because it promotes the secretion of bile from the liver, bile ducts and gall bladder, and contribute entering it into the duodenum. In addition, they have anti-inflammatory, antimicrobial and antihelminthic effect.

The herb horsetail has anti-inflammatory and antimicrobial actions, strengthens and neutralizing immune properties of the organism. She may have a detoxifying effect, helping to eliminate lead and its derivatives from the body, including the liver. The herb horsetail strengthens the walls of blood vessels, enhances the removal of sand from liver passages and small stones from the gallbladder, t is m the restoring haeres.

The mixture is ground to a powder consistency, then 2/3 teaspoon brewed in 300 ml of boiling water, insist 15 minutes, Take 100 ml three times a day after meals at normal and high pH, while cold - following the same pattern before meals for one and a half months. Depending on the condition of the patient is recommended 2 to 4 courses of treatment.

As examples are extracts from the histories.

Example 1.

Case history No. 1626. Patient S., aged 57.

The diagnosis of drug-induced hepatitis with moderate activity in patients receiving diclofenac.

The patient complained of aching pain in the right hypochondrium, weakness, nausea, anorexia, unstable stool, itching and yellowness of the skin and mucosa. Ill 3 months, when taking diclofenac about joint pain pains in the right hypochondrium, weakness, nausea, yellowness of the skin. Were treated in the clinic, took Kars, CREON. Two weeks before admission to the clinic increased pain, increased weakness, appeared anorexia, yellowness and itchy skin.

Objectively: the patient is in satisfactory condition, the skin and mucous icterina, traces of scratches on the skin. The pulse 66 beats per 1 minute, rhythmic. HELL 115/70 mm Hg muffled heart sounds, vesicular breathing, wheezing no. Tongue coated belemnella, the belly of the correct form, swollen, palpation painful in the right hypochondrium, enlarged liver is palpated, the lower edge of which comes from under the costal arch 2 cm, spleen, kidneys are not palpable.

Blood analysis: HB 115,0 g/l, er 3.7 x 1012/l, leukocytes to 8.6×109/l, WBC (p 0,43×109/l, 5,16×109/l e of 0.68×109/l, b 0,08×109/l l of 1.37×109/l, m 0,h9/l), platelets 174,0×109/l, erythrocyte sedimentation rate of 23 mm/hour.

Urine analysis: urine bright, acidic, share 1014, protein - tracks, urobilin (+), leukocytes 1-3 in p. SP.

Biochemical blood test: whole protein 64,0 g/l, albumin 44%, globulins 56%, cholesterol 6.7 mmol/l, AST of 2.40 mmol/l, Alt of 2.50 mmol/l, thymol test of 5.3%, bilirubin 41.5 μmol/l, alkaline phosphatase 150,0 u/l, prothrombin index 68,0%.

Ultrasound of the abdominal organs, the liver is enlarged, diffuse changed out from under the costal arch 2 cm, pancreas, spleen, kidneys are not changed. HBsAg (-), HCV IgM (-).

In the clinic, patient treatment: Essentiale 2 capsules 3 times a day for 10 days. On the background of therapy the patient's condition improved slightly - decreased pain in the right hypochondrium, increased weakness, itching, and yellowness of the skin.

Blood analysis: HB 112 g/l, er of 3.6×1012/l, leukocytes 8,4×109/l, WBC (p 0,42×109/l l 5,04×1 9/l e of 0.58×109/l, b 0,16×109/l l of 1.52×109/l, m 0,67×109/l), platelets 176,0×109/l, erythrocyte sedimentation rate of 21 mm/hour.

Urinalysis - urine is bright, acidic, share 1013, protein - tracks, urobilin (++), leukocytes 0-1-2 in p. SP.

Biochemical blood test: whole protein 65 g/l, albumin 44%, globulins 56%, cholesterol 6.1 mmol/l, ASAT 2.2 mmol/l, Alat 2.00 mmol/l, thymol test of 5.1%, bilirubin 38,0 µmol/l, alkaline phosphatase 160 u/l, prothrombin index 68,0%.

Ultrasound of organs - the liver is diffusely enlarged, out from under the costal arch on 3 cm, spleen, kidneys are not changed.

Additional patient assigned to a medicinal collection of plants, including grass, wild strawberry 5 (25), the herb dandelion 4 (20), chamomile flowers bezyazykove 10 (50), the leaf of nettle 6 (30), inflorescence tansy 2 (10), florets of calendula 1(5), the fruits of Juniperus communis l 5 (25), peppermint leaves 8 (40), the herb Hypericum perforatum 9 (45), lime flowers, 20 (100), grass tricolor violet 19 (95), the herb centaury 6 (30), flax seed 10 (50), seed dill 9 (45), burdock root 4 (20), the herb chicory ordinary 7 (35), grass knotweed 6 (30), stems hop ordinary 8 (40), grass, cornflower blue 3 (15), bilberry leaf 6 (30), bearberry leaf 3 (15), corn stigmas 7 (35), grass immortelle 4 (20), the roots and rhizomes of calamus 5 (25), the grass watch the Tr is hostoi 7 (35), the root of Angelica 7 (35), the herb of melilot drug 8 (40), elecampane root 7 (35), a grass of a horsetail 6 (30).

The mixture was ground to a powder consistency, then 2/3 teaspoon was poured on 300 ml of boiling water, insist 15 minutes the mixture stood for, and the patient was taken in a 100 ml three times a day for a month and a half.

After the treatment the patient's condition has improved, no pain in the right hypochondrium, weakness, nausea, anorexia, itching, and yellowness of the skin. An objective study of the skin and mucous clean, normal color. The heart rate of 78 beats per 1 minute, rhythmic. HELL 120/80, muffled heart sounds, vesicular breathing, wheezing no. The language is clean, the abdomen is soft, painless on palpation, the liver comes out from under the costal arch 0.5 cm, pancreas, spleen, kidneys are not palpable.

Blood analysis: HB 118 g/l, erythrocytes of 3.9×1012/l, leukocyte count of 6.4×109/l, WBC (p 0,19×109/l, of 4.16×109/l e of 0.25×109/l, b 0,06×109/l l of 1.34×109/l, m of 0.38×109/l), platelets 190,0×109/l, erythrocyte sedimentation rate 12 mm/hour.

Urinalysis - urine is bright, acidic, share 1013, no protein, urobilin no, WBC 0-1 in p. SP.

Biochemical blood test: whole protein 73,0 g/l, albumin 48%, globulins 52%, cholesterol 5.4 mmol/l, ASAT 0.33 mmol/l, Alat 0.30 mmol/l thymol is Rob 3,5%, bilirubin 20.0 µmol/l, alkaline phosphatase 92 u/l, prothrombin index 71%.

Ultrasound of abdominal organs - the liver decreased in size, out pogrebennoi arc 0.5 cm, pancreas, spleen, kidneys are not changed. The duration of treatment until full recovery 36 days.

Example 2.

Case history No. 727. Patient E., 58 y.o.

The diagnosis of drug-induced hepatitis with moderate activity in patients receiving diclofenac.

The patient complained of aching pain in the right hypochondrium, nausea, anorexia, weakness, unstable stool, itching and yellowness of the skin and mucosa. Sick 4 months, when taking diclofenac about pain in the calf muscles of the lower leg pains in the right hypochondrium, weakness, nausea, yellowness of the skin. Were treated in the clinic, took Kars, CREON. Two weeks before admission to the clinic increased pain, increased weakness, appeared anorexia, continues to be the yellowness and itchy skin.

Objectively: the patient is in satisfactory condition, the skin and mucous icterina, traces of scratches on the skin. The pulse 66 beats per 1 minute, rhythmic. HELL 115/70 mm Hg muffled heart sounds, vesicular breathing, wheezing no. The white furred tongue, belly right shape, swollen, palpation painful in the right upper quadrant is palpated increased pécs is Ni, the lower edge of which comes from under the costal arch 2 cm, spleen, kidneys are not palpable.

Blood analysis: HB 112,0 g/l, er of 3.8×1012/l, leukocytes 8,4×109/l, WBC (p 0,42×109/l, with 5,04×109/l e of 0.67×109/l, b 0,08×109/l l of 1.34×109/l, m 0,84×109/l), platelets 175,0×109/l, erythrocyte sedimentation rate of 24 mm/hour.

Urine analysis: urine bright, acidic, share 1014, protein - tracks, urobilin (+), leukocytes 1-3 in p. SP.

Biochemical blood test: whole protein 65.0 g/l, albumin 45%, globulins 55%, cholesterol to 6.8 mmol/l, ASAT 2,60 mmol/l, Alat 2,70 mmol/l, thymol test of 5.6%, bilirubin 41,0 µmol/l, alkaline phosphatase 160,0 u/l, prothrombin index 67,0%.

Ultrasound of organs - the liver is diffusely enlarged, out from under the costal arch 2 cm, spleen, kidneys are not changed.

In the clinic, patient treatment: Essentiale 2 capsules 3 times a day. On the background of therapy the patient's condition improved slightly - decreased pain in the right hypochondrium, increased weakness, itching, and yellowness of the skin.

Blood analysis: HB 112 g/l, er of 3.6×1012/l, leukocyte count of 8.2×109/l, WBC (p 0,41×109/l l to 4.92×109/l e of 0.57×109/l, b 0,16×109/l l of 1.47×109/l, m 0,65×109/l), platelets 178,0×109/l, erythrocyte sedimentation rate of 20 mm/hour.

Urinalysis - urine is bright, acidic, share 1013, protein-trace, the urobilin (++), leukocytes 0-1-2 in p. SP.

Biochemical blood test: whole protein 66 g/l, albumin 44%, globulins 56%, cholesterol 6.0 mmol/l, ASAT 2.0 mmol/l, Alat 1,90 mmol/l, thymol test of 5.2%, bilirubin 36,0 µmol/l, alkaline phosphatase 158 u/l, prothrombin index 68,0%.

Ultrasound of organs - the liver is diffusely enlarged, out from under the costal arch 2 cm, spleen, kidneys are not changed.

Additional patient assigned to a medicinal collection of plants, including grass forest strawberries 6 (30), the herb dandelion 5 (25), chamomile flowers bezyazykove 11 (55), the leaf of nettle 7 (35), inflorescence tansy 3 (15), florets of calendula 2 (10), the fruits of Juniperus communis l 6 (30), peppermint leaves 9 (45), the herb Hypericum perforatum 10 (50), lime flowers, 21 (105), grass tricolor violet 20 (100), the herb centaury 7 (35), flax seed 11 (55), seed dill 10 (50), burdock root 5 (25), the herb chicory ordinary 8 (40), grass knotweed 7 (35), stems hop ordinary 9 (45), grass, cornflower blue 4 (20), bilberry leaf 7 (35), bearberry leaf 4 (20), corn stigmas 8 (40), grass immortelle 5 (25), the roots and rhizomes of calamus 6 (30), the grass watch three leaf 8 (40), the root of Angelica 8 (40), grass clover medicinal 9 (45), elecampane root 8 (40), a grass of a horsetail 7 (35).

The mixture was ground to a powder consistency, then 2/3 h is Inoi spoon was poured on 300 ml of boiling water, insisted 15 minutes the mixture stood for, and the patient was taken in a 100 ml three times a day for a month and a half.

After the treatment the patient's condition has improved, no pain in the right hypochondrium, weakness, itching, and yellowness of the skin.

An objective study of the skin and mucous net. The heart rate of 78 beats per 1 minute, rhythmic. HELL 120/80, muffled heart sounds, vesicular breathing, wheezing no. The language is clean, the abdomen is soft, painless on palpation, the liver comes out from under the costal arch 0.5 cm, pancreas, spleen, kidneys are not palpable.

Blood analysis: HB 120 g/l, erythrocytes of 4.1×1012/l, leukocyte count of 6.1×109/l, leukocyte formula (p 0,18×109/l, of 3.96×109/l e of 0.24×109/l, b 0,06×109/l l 1,28×109/l, m 0,36×109/l), platelets 200,0×109/l, ESR 10 mm/hour.

Urinalysis - urine is bright, acidic, share 1013, no protein, urobilin no, WBC 0-1 in p. SP.

When biochemical blood test: whole protein of 74.0 g/l, albumin 49%, globulins 51%, cholesterol 5.1 mmol/l, ASAT 0.32 mmol/l, Alat 0.25 mmol/l, thymol test of 3.2%, bilirubin 20.0 µmol/l, alkaline phosphatase 85 u/l, prothrombin index 71%.

Ultrasound of abdominal organs - the liver decreased in size, not out pogrebennoi arc, pancreas, spleen, kidneys not changed what.

The duration of treatment until full recovery 30 days.

Example 3.

Case history No. 265. Patient T., 59 years old.

The diagnosis of drug-induced hepatitis with moderate activity in patients receiving diclofenac.

The patient complained of aching pain in the right hypochondrium, weakness, nausea, irregular stools, itching and yellowness of the skin and mucosa. Hurts 3.5 months, when after exercise pains in the lumbar spine. For relieving pain took diclofenac. In patients receiving the drug experienced pain in the right hypochondrium, weakness, yellowness of the skin. Were treated in the clinic, took Kars, CREON. Two weeks before admission to the clinic increased pain, increased fatigue, yellowness and itchy skin.

Objectively: the patient is in satisfactory condition, the skin and mucous icterina, traces of scratches on the skin. The pulse 66 beats per 1 minute, rhythmic. HELL 115/70 mm Hg muffled heart sounds, vesicular breathing, wheezing no. The white furred tongue, belly right shape, swollen, palpation painful in the right hypochondrium, enlarged liver is palpated, the lower edge of which comes from under the costal arch 2 cm, spleen, kidneys are not palpable.

In blood: HB 115,0 g/l, er of 3.8×1012/l, leukocyte count of 8.5×109/l (p 0,42×109/l, 5,10×109/l e of 0.6×10 9/l, b 0,08×109/l l of 1.36×109/l, m 0,85×109/l), platelets 176,0×109/l, ESR 25 mm/hour.

Urine analysis: urine bright, acidic, share 1014, protein - tracks, urobilin (+), leukocytes 1-3 in p. SP.

When biochemical blood test: whole protein 66,0 g/l, albumin 46%, globulins 54%, cholesterol to 6.9 mmol/l, AST of 2.50 mmol/l, Alat 2,60 mmol/l, thymol test of 5.1%, bilirubin 37.5 µmol/l, alkaline phosphatase 170,0 u/l, prothrombin index 66,0%.

Ultrasound of the abdominal organs, the liver is enlarged, diffuse changed out from under the costal arch 2 cm, pancreas, spleen, kidneys are not changed. HBsAg (-), HCV IgM (-).

In the clinic, patient treatment: Essentiale 2 capsules 3 times a day. On the background of therapy the patient's condition improved slightly - decreased pain in the right hypochondrium, at the same time, increased weakness, itching, and yellowness of the skin, appeared anorexia.

In blood: HB 112 g/l, er of 3.6×1012/l, leukocyte count of 8.1×109/l (p 0,40×109/l l a 4.86×109/l e of 0.57×109/l, b 0,16×109/l l to 1.45×109/l, m 0,64×109/l), platelets 179,0×109/l, erythrocyte sedimentation rate of 20 mm/hour.

Urinalysis - urine is bright, acidic, share 1013, protein - tracks, urobilin (++), leukocytes 0-1-2 in p. SP.

When biochemical blood test: whole protein 66 g/l, albumin 45%, globulins 55%, cholesterol 5,9 IMO the b/l, AST 2.1 mmol/l, Alat 1,90 mmol/l, thymol test of 5.0%, bilirubin 34,0 µmol/l, alkaline phosphatase of 1.6 u/l, prothrombin index 68,0%.

Ultrasound of organs - the liver is diffusely enlarged, out from under the costal arch on 3 cm, spleen, kidneys are not changed.

Additional patient assigned to a medicinal collection of plants, including grass forest strawberries 7 (35), grass dandelion 6 (30), chamomile flowers bezyazykove 12 (60), the leaf of nettle 8 (40), inflorescence tansy 4 (20), florets of calendula 3 (15), the fruits of Juniperus communis l 7 (35), peppermint leaves 10 (50), the herb Hypericum perforatum 11 (55), lime flowers, 22 (110), grass tricolor violet 21 (105), the herb centaury 8 (40), flax seed 12 (60), seed dill 11 (55), burdock root 6 (30), the herb chicory ordinary 9 (45), grass knotweed 8 (40), stems hop ordinary 10 (50), grass, cornflower blue 5 (25), bilberry leaf 8 (40), bearberry leaf 5 (25), corn stigmas 9 (45), grass immortelle 6 (30), the roots and rhizomes of calamus 7 (35), the grass watch three leaf 9 (45), the root of Angelica 9 (45), the herb of melilot drug 0 (50), elecampane root 9(45), a grass of a horsetail 8 (40).

The mixture was ground to a powder consistency, then 2/3 teaspoon was poured on 300 ml of boiling water, insist 15 minutes the mixture was defended and the patient was taken in a 100 ml three times a day in those who tell one and a half months.

After the treatment the patient's condition has improved, no pain in the right hypochondrium, weakness, nausea, anorexia, itching, and yellowness of the skin.

An objective study of the skin and mucous net. The heart rate of 78 beats per 1 minute, rhythmic. HELL 120/80, muffled heart sounds, vesicular breathing, wheezing no. The language is clean, the abdomen is soft, painless on palpation, the liver comes out from under the costal arch 0.5 cm, pancreas, spleen, kidneys are not palpable.

Blood analysis: HB 119 g/l, erythrocytes 4,0×1012/l, leukocytes to 6.2×109/l (p 0,18×109/l, with a 4.03×109/l e of 0.24×109/l, b 0,06×109/l l of 1.30×109/l, m 0,37×109/l), platelets 195,0×109/l, erythrocyte sedimentation rate of 11 mm/hour.

Urinalysis - urine is bright, acidic, share 1013, no protein, urobilin no, WBC 0-1 in p. SP.

Biochemical analysis: total protein 73,0 g/l, albumin 48%, globulins 52%, cholesterol 5.2 mmol/l, ASAT 0.35 mmol/l, Alat 0.27 mmol/l, thymol test of 3.3%, bilirubin 20.0 µmol/l, alkaline phosphatase 87 u/l, prothrombin index 71%. Ultrasound of abdominal organs - the liver decreased in size, out pogrebennoi arc 0.5 cm, pancreas, spleen, kidneys are not changed.

The duration of treatment until full recovery 35 days.

Example 4. (method-prototype)

Case history No. 1056. Patient R., 56.

Diagnostics is: drug-induced hepatitis with moderate activity in patients receiving diclofenac.

The patient complained of aching pain in the right hypochondrium, nausea, weakness, unstable stool, itching and yellowness of the skin and mucosa. Sick about 4 months, when for relieving pain in the knee joint was taking diclofenac. In patients receiving the drug experienced pain in the right hypochondrium, weakness, yellowness of the skin. Were treated in the clinic, took Kars, CREON. Two weeks before admission to the clinic increased pain, increased fatigue, yellowness and itchy skin.

Objectively: the patient is in satisfactory condition, the skin and mucous icterina, traces of scratches on the skin. The pulse 66 beats per 1 minute, rhythmic. HELL 115/70 mm Hg muffled heart sounds, vesicular breathing, wheezing no. The white furred tongue, belly right shape, swollen, palpation painful in the right hypochondrium, enlarged liver is palpated, the lower edge of which comes from under the costal arch 2 cm, spleen, kidneys are not palpable.

Blood analysis: HB 110,0 g/l, er 3.7 x 1012/l, leukocyte count of 8.2×109/l, leukocyte formula (p 0,41×109/l, with of 5.00×109/l e 0,65×109/l, b 0,16×109/l l to 1.23×109/l, m to 0.73×109/l), platelets 175,0×109/l, erythrocyte sedimentation rate of 22 mm/hour.

Urine analysis: urine bright, acidic, share 1014, protein - tracks, urobilin (+), leukocytes 1-3 in p. SP.

Biochemical ASCS shall adowanie blood: total protein 66,0 g/l, albumin 45%, globulins 55%, cholesterol to 6.9 mmol/l, AST of 2.40 mmol/l, Alt of 2.50 mmol/l, thymol test of 5.6%, bilirubin 35,0 µmol/l, alkaline phosphatase 150,0 u/l, prothrombin index 68,0%.

Ultrasound of the abdominal organs, the liver is enlarged, diffuse changed out from under the costal arch 2 cm, pancreas, spleen, kidneys are not changed. HBsAg (-), HCV IgM (-).

In the clinic, patient treatment: Essentiale 2 capsules 3 times a day. On the background of therapy the patient's condition improved slightly - decreased pain in the right hypochondrium, at the same time, increased weakness, itching, and yellowness of the skin. In blood: HB 112 g/l, er of 3.6×1012/l, leukocyte count of 8.1×109/l, leukocyte formula (p 0,32×109/l, with 5,04×109/l e of 0.64×109/l, b 0,08×109/l l 1,28×109/l, m 0,64×109/l), platelets 180,0×109/l, erythrocyte sedimentation rate of 21 mm/hour.

Urinalysis - urine is bright, acidic, share 1013, protein - tracks, urobilin (++), leukocytes 0-1-2 in p. SP.

Biochemical blood test: whole protein 64 g/l, albumin 44%, globulins 56%, cholesterol 6.2 mmol/l, ASAT 2.10 mmol/l, Alat 1,90 mmol/l, thymol test of 5.2%, bilirubin 34,0 µmol/l, alkaline phosphatase 145 u/l, prothrombin index 68,0%.

Ultrasound of organs - the liver is diffusely enlarged, out from under the costal arch on 3 cm, spleen, kidneys are not changed.

Additionally, b is assigned through medicinal plants gathering, includes: alder buckthorn bark of 20.0 g; herb Polygonum pepper 20,0 g; grass forest strawberries 20,0 g; herb Bupleurum aureum 20,0 g; grass lnjanki ordinary 20,0 g; the root of the dandelion 20,0 g; leaf of nettle 20,0; inflorescence tansy 20,0; inflorescences chamomile 10,0; herb calendula 10,0; the fruits of Juniperus communis l 10,0; peppermint leaves 10,0; grass Hypericum perforatum 10,0; grass celandine and 10.0. One tablespoon of the mixture brew 0,5 liter of boiled water, to insist 30 minutes, strain and drink per day in three doses for 10-15 minutes before eating. The mixture was ground to a powder consistency, then 2/3 teaspoon was poured on 300 ml of boiling water, insist 15 minutes the mixture was defended and the patient was taken in a 100 ml three times a day for a month and a half.

After the treatment the patient's condition has improved slightly decreased pain in the right hypochondrium, weakness, itching, and yellowness of the skin.

An objective study of the skin and mucous jaundice. The heart rate of 78 beats per 1 minute, rhythmic. HELL 120/80, muffled heart sounds, vesicular breathing, wheezing no. The language is clean, the abdomen is soft, painful in the right hypochondrium, palpation of the liver comes out from under the costal arch to 1.5 cm, pancreas, spleen, kidneys are not palpable.

Ana is from the blood: HB 115 g/l, erythrocytes of 3.8×1012/l, leukocyte count of 7.2×109/l, leukocyte formula (p 028×109/l, 4,60×109/l e of 0.42×109/l, b 0,14×109/l platelets 180,0×109/l, erythrocyte sedimentation rate of 18 mm/hour.

Urinalysis - urine is bright, acidic, share 1013, no protein, urobilin (+), WBC 0-1 in p. SP.

Biochemical blood test: whole protein 68,0 g/l, albumin 46%, globulins 54%, cholesterol 6.0 mmol/l, ASAT 1.10 mmol/l, Alat 1.00 mmol/l, thymol test of 4.1%, bilirubin 28,0 µmol/l, alkaline phosphatase 100 u/l, prothrombin index 69%.

Ultrasound of abdominal organs - the liver was slightly decreased in size, out pogrebennoi arc-1.5 cm, pancreas, spleen, kidneys are not changed.

The duration of treatment until full recovery 49 days.

Thus, the above extracts from the records show that the acceptance of the proposed collection of positive effect was obtained in all patients.

After treatment in patients with drug hepatitis by using the proposed collection (table 1) in patients with improved clinical and laboratory findings due to the normalization choleresis, restore biochemical and physiological processes in the liver. Comparative data on the treatment of patients with hepatitis C drug application prototype presented in Table 2.

The duration of treatment observed in patients decrease is knit together in 16 days. On the way to prototype the treatment time is 49 days, and by the present method is 33 days.

Thus, the advantage of the proposed collection is to strengthen the detoxifying action of drug collection, manifested in the normalization of the functional state of the liver, and reduction of terms of treatment of patients with drug-induced hepatitis.

Table 1
The effectiveness of the proposed herb gathering in the treatment of patients with drug hepatitis
IndicatorsBefore the treatmentAfter the treatment
HospitalPAfter the treatmentP
Hemoglobin, g/l115,0±2,9113,5±3,0>0,05119,6±2,8>0,05
Red blood cells, ×1012lof 3.77±0,3the 3.65±0,25>0,053,98±0,28>0,05
The leukocyte count, ×109l8,2±0,56,15±0,6<0,056,1±0,5<0,05
Eosinophils, ×109l0,68±0,0030,57±0,004>0,050,25±0,004<0,05
Monocytes, ×109l0,85±0,0050,65±0,006<0,050,37±0,006<0,05
Platelets, ×109/l178,0±14,0of 186.0±15,0>0,05192,0±15,0->0,05
ESR, mm/hour24,0±3,020,0±2,512,0±2,3-<0,05
Total protein, g/l65,0±2,066,0±2,1>0,0574,0±2,2<0,05
Albumin, % 45,0±1,3450±1,6>0,0549,0±1,3<0,05
Globulins, %55,0±1,555,0±1,4>0,0551,0±1,3<0,05
AST, mmol/l2,50±0,152,1±0,16>0,050,41±0,11<0,05
Alat, mmol/l2,60±0,141,95±0,10<0,050,43±0,10<0,05
Thymol turbidity test unit5,3±0,415,10±0,39>0,053,6±0,40<0,05
Cholesterol, mmol/l6,8±0,606,0±0,50>0,055,2±0,52>0,05
Alkaline phosphatase, u/l160,0±10,0159,0±11,0 >0,0575,0±0,6<0,05
Bilirubin, µmol/l41,0±2,237,0±2,7>0,0518,1±1,5<0,05
Prothrombin index, %67,0±6,368,2±6,0>0,0575,0±6,7>0,05
The duration of treatment up to the normalization of clinical and laboratory manifestations (days)--33

Table 2
The collection efficiency of the prototype in the treatment of patients with drug hepatitis
IndicatorsBefore the treatmentAfter the treatment
HospitalPAfter the treatmentP
Hemoglobi is h, g/l110,0±2,5112,0±3,0>0,05115,0±2,5>0,05
Red blood cells, ×1012l3,7±0,43,6±0,27>0,053,8±0,35>0,05
The leukocyte count, ×109l8,2±0,58,0±0,6>0,057,2±0,6>0,05
Eosinophils, ×109l0,65±0,0080,64±0,006>0,050,43±0,008>0,05
Basophils, ×109l0,73±0,0070,64±0,005>0,050,50±0,008>0,05
Platelets, ×109/l175±16,0180,0±16,5>0,05180,0±17,3>0,05
ESR, mm/hour 22,0±1,521,0±2,1>0,0518,0±1,6>0,05
Total protein, g/l66,0±2,164,0±2,3>0,0568,0±2,0>0,05
Albumin, %45,0±1,644,0±1,4>0,0546,0±1,5>0,05
Globulins, %55,0±1,456,0±1,6>0,0554,0±1,4>0,05
AST, mmol/l2,40±0,122,10±0,14>0,051,10±0,11<0,05
Alat, mmol/l2,50±0,211,90±0,23>0,051,0±0,10<0,05
Thymol turbidity test unit5,6±0,425,2±0,40 >0,054,1±0,43>0,05
Cholesterol, mmol/l6,9±0,596,2±0,60>0,056,0±0,53>0,05
Alkaline phosphatase, u/l150,0±12,0145,0±10,0>0,05100,0±0,10>0,05
Bilirubin, µmol/l35,0±2,334,0±2,5>0,0528,0±2,0<0,05
Prothrombin index, %68,0±6,468,08±7,0>0,0569,0±6,9>0,05
The duration of treatment up to the normalization of clinical and laboratory manifestations (days)--49

The treatment for patients with drug-induced hepatitis, which represents an herbal blend that includes: grass land is aniki forest, grass dandelion, chamomile flowers bezyazykove, leaf of nettle, inflorescence tansy, florets of calendula, the fruits of common juniper, peppermint leaves, grass Hypericum perforatum, characterized in that it further comprises lime flowers, grass tricolor violet, herb centaury, flax seed, dill seed, burdock root, herb, chicory ordinary, grass knotweed, stems hop ordinary, grass, cornflower blue, bilberry leaf, bearberry leaf, corn stigmas, grass immortelle, roots and rhizomes of calamus, the grass watch three leaf, Angelica root, the herb of melilot drug the root of Valerian, horsetail grass, at the following mass ratio of components:

The wild strawberry, the grass5-7
The dandelion, grass4-6
Daisy bezyazykove, inflorescence10-12
Stinging nettle leaf6-8
Common tansy, inflorescence2-4
Calendula officinalis, inflorescence 1-3
Juniperus communis fruit5-7
Peppermint, sheet8-10
St. John's wort, herb9-11
Linden flowers20-22
Viola tricolor, grass19-21
Centaury, grass6-8
The flax seed10-12
Seed dill9-11
Burdock root4-6
Endive ordinary grass7-9
Knotweed grass6-8
Hops ordinary, infructescences8-10
Cornflower blue, grass3-5
Cranberries, the leaf6-8
Bearberry leaf3-5
Corn stigmas7-9
Immortelle, grass4-6
Air, roots and rhizomes5-7
Watch three leaf grass7-9
Angelica root7-9
The clover medicinal, herb8-10
Elecampane root7-9
Horsetail grass6-8



 

Same patents:

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine. Mixture consists of medicinal plants: inflorescences of pot marigold, peppermint leaves, Baikal skullcap root, black leaves and root of badan, shoots of shrubby cinquefoil, with the following component ratio, wt fr.: inflorescences of pot marigold 3; peppermint leaves 1; Baikal skullcap root 2; rhizome and black leaves of badan - 1+1; shoots of shrubby cinquefoil 2. Clinical treatment with claimed mixture has resulted in positive effect in case of alcoholic hepatitis in 150 patients.

EFFECT: creation of mixture for treatment and prevention of alcoholic hepatitis.

10 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to chemical-pharmaceutical industry, namely to creation of medication, which possesses hepatoprotective, detoxicating and regenerating action. Medication contains in its composition essential phospholipids, vitamin B1, vitamin B2, vitamin B6, vitamin E, extract of milk thistle, extract of artichoke and auxiliary substances. Claimed medication extends arsenal of hepatoprotective medications, which possess wide pharmacologic spectrum of action.

EFFECT: medication corresponds to polyvalency of disease pathogenesis, affects patient's organism as a whole as corrective system.

2 ex, 3 tbl

FIELD: medicine.

SUBSTANCE: invention refers to veterinary science, namely to therapy of internal non-transmitting diseases, particularly to drugs for pig hepatosis prevention. The agent for pig hepatosis prevention contains the ingredients in the following relation: antihepatotoxic serum 0.9-1.15 titre units; antisplenotoxic serum 0.9-1.15 titre units; leukocyte plasma 90-110 embryo units; phenol 0.004-0.005 mg; physiologic saline up to 1 ml.

EFFECT: invention allows higher effectiveness of pig hepatosis prevention.

4 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of general formula (I) , where the dotted line is either absent or denotes a double bond; R1 denotes H or C1-6-alkyl, possibly substituted with a CN group, or denotes a phenyl or sulphonyl phenyl, substituted with one or more B groups, or denotes -(CH2)m-Ra, where Ra denotes: NRiRii, C3-6-cycloalkyl, 6-member heterocycloalkyl, which denotes a univalent saturated group which contains one nitrogen heteroatom, the rest are carbon atoms, aryl, which can be substituted with one or more B groups, or denotes -(CH2)n-(CO)-Rb or -(CH2)n-(SO2)-Rb, where Rb denotes: NRiRii, 5-6-member heterocycloalkyl, which denotes a univalent saturated group containing one or more heteroatoms selected from nitrogen, oxygen, the rest are carbon atoms, aryl or 5- or 6-member heteroaryl, which denotes an aromatic ring containing two heteroatoms as ring members, the said heteroatoms selected from N or O, the rest are carbon atoms; which can possibly be substituted with one or more B groups, R2 denotes one or more H, halo, C1-6-alkyl, C1-6-alkoxy, R3 denotes H or-(CO)-Rc, where Rc denotes: C1-6-alkyl, 5-member heterocycloalkyl, which denotes a univalent saturated group containing one nitrogen heteroatom, the rest are carbon atoms possibly substituted with C1-6-alkyl, or denotes C1-6-alkyl; R4 denotes H; R5 denotes H, C1-6-alkyl, -(CH2)m-NRiRii, -(CH2)n-(CO)-Rb, where Rb denotes NRiRii or a 6-member heterocycloalkyl which denotes a univalent saturated group which contains one nitrogen heteroatom, the rest are carbon atoms, when the dotted line is absent or is absent when the dotted line denotes a double bond; R6 is absent, when the dotted line denotes a double bond; R7 denotes Cl or NReRf, where Re and Rf denotes H or C1-6-alkyl, or Re and Rf together with the nitrogen atom to which they are bonded form a 6-member heterocycloalkyl which denotes a univalent saturated group containing one or two heteroatoms selected from nitrogen, oxygen, the rest are carbon atoms; which can be substituted with C1-6-alkyl, or R6 and R7 together form a C=O group, when the dotted line is absent; B denotes halogen, C1-6-alkoxy, (CRiiiRiv)n-phenyl; Ri and Rii denote H, C1-6-alkyl -C(O)-C1-6-alkyl; Riii and Riv denote C1-6-alkyl; m equals to 1 or 2, n equals 0 or 1; as well as to pharmaceutically acceptable salts thereof. The invention also relates to a pharmaceutical composition, as well as to use of compounds of formula (I), (I-a) or (1-b).

EFFECT: obtaining novel biologically active compounds having activity on V1a receptor.

12 cl, 48 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to new oxoazepanylacetamide and oxoazepanylphenoxyacetamide derivatives, or to their stereoisomers or pharmaceutically acceptable salts described by general formula I where Q means O, S or N(R25); R25 means H; R80 is C6arylC1-4alkyl substituted by one or two substituted independently chosen from R3 groups; each R3 is independently chosen from a group including C1-4alkyl, C1-4alkoxy group, C2-6alkenyloxy group, halogen, C6aryloxy group, N(R20)(R21), R50, heteroaryl chosen from pyridine and thiazol where each alkoxy group and heteroaryl has optionally up to three substitutes independently chosen from R61 groups; and alkyl has optionally three substitutes independently chosen from R60 groups; or two R3 groups when they are present on carbon neighbours, together can form a fragment of formula -(O)a-(CH2)b-(O)c-(CH2)d-(O)e- where a, c and e independently mean 0 or 1, and both b and d independently mean 0, 1, 2 or 3; provided the fragment does not contain two oxygen neighbors and summed a, b, c, d and e are equal to 3 at least; R1 is chosen from a group including H, C1-4alkyl, C6arylC1-4alkyl; each R60 independently is chosen from a group including C1-C6a alkoxy group, NR12R13, halogen, heterocycloalkyl, such as piperidine; each R61 independently is chosen from a group including R60 and C1-C6alkyl; X means a group of formula -(CH2)n- where n means 2 or 3; or a group of formula II where Y means CH2, S; R75 and R76 means H; Z means C6aryl or heteroaryl, such as pyridine; each of which has optionally one substitutes chosen from R2 groups; R2 is chosen from a group including H, C1-4alkyl, halogen, heterocycloalkylC1-4alkyl, C6arylC1-4alkylaminoC1-4alkyl and a group of formula -(CH2)fN(R11)-(R10); where each heterocycloalkyl, arylalkylaminoalkyl has oprtionally one substitute chosen from R61 groups; f means 1; R11 means H; R10 means C1-6alkyl, C2-6alkenyl, C3-8cycloalkyl, aryl, C6arylC1-4alkyl, heteroarylC1-4alkyl where aryl has optionally one substitute chosen from R61 groups; each R12 and R13 independently mean C1-4alkyl; each R20 and R21 independently mean C1-4alkyl where alkyl has optionally one substitute chosen from R60 groups; and provided that the compound does not represent N-(4-ethoxybenzyl)-N-(2-oxoazepane-2-yl)-2-phenoxyacetamide or N-[(2-fluorophenyl)methyl]-N-(2- oxoazepane-3-yl)-2,2-diphenylacetamide. Also, the invention refers to a pharmaceutical composition of the compound of formula I, to methods of treating HCV viral infection and methods of relieving the symptoms of HCV viral infection with using the compound of formula I.

EFFECT: there are produced new oxoazepanylacetamide and oxoazepanylphenoxyacetamide derivatives showing HCV replication inhibiting activity.

1 tbl, 9 ex

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula (I), where R2 denotes H, [(C1-C6) alkylene]0-1-R'; R3 denotes H; R4 denotes H, halogen or (C1-C6) alkyl; R5 denotes H or halogen; R6 denotes H, (C1-C8) alkyl, R', (C1-C6) alkylene-R'; R7 and R8 independently denote H, halogen, (C1-C6) alkyl, O-(C1-C6) alkyl, R'; R9 denotes (C1-C6)alkyl; n equals 0 or 1; L denotes O or O-(C1-C6)alkylene; where R' denotes (C3-C8) cycloalkyl; (C5-C10)heterocyclyl, which denotes an aromatic or saturated mono- or bicyclic ring system which, besides a carbon atom, includes one or more heteroatoms such as nitrogen, oxygen and sulphur atoms; or (C6-C10) aryl; where in the heterocyclyl is unsubstituted or substituted with (C1-C6)alkyl, and the aryl is unsubstituted or substituted with a halogen, (C1-C4)alkyl, -O-(C1-C4)alkyl, SO2- (C1-C4) alkyl or N[(C1-C4) alkyl]2; and where in groups R4, R6 and R7 the alkyl can be halogenised in one or more positions; or pharmaceutically acceptable salts and/or stereo isomer forms thereof. The invention also relates to use of formula (I) compounds, as well as a medicinal agent.

EFFECT: obtaining novel biologically active compounds having Rho-kinase inhibiting activity.

21 cl, 320 ex, 3 tbl

FIELD: medicine, veterinary science.

SUBSTANCE: invention refers to veterinary science, namely to therapy of internal nontransmitting diseases, particularly to drugs for chicken hepatosis prevention. The agent for chicken hepatosis prevention contains the ingredients in the following relation: antihepatotoxic serum 0.9-1.15 titre units; antisplenotoxic serum 0.9-1.15 titre units; phenol 0.004-0.005 mg; physiological solution up to 1 ml. The agent is introduced to chickens and chicks in dose 0.2 ml/kg of body weight subcutaneously or intramuscularly.

EFFECT: invention allows higher effectiveness of chicken hepatosis prevention.

4 tbl

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to hepatology, and can be applied in treatment of chronic hepatitis, caused by TTV virus. Method consists in simultaneous application of medication Amixin 0.125 in dose 1 pill every second day during 3 months in combination with medication fosfogliv in dose 2 pills 3 times per day during 3 months, with simultaneous treatment of sex partner.

EFFECT: application of invention allows to reach eradication of TTV form patient's organism with reduction of treatment time and reduction of complication quantity.

1 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to pharmacology and cell technologies. Medication, possessing regenerative activity, represents granulocytic colony-stimulating factor, immobilised on water-soluble polymers with molecular weight 400-4000 Da. Granulocytic colony-stimulating factor is immobilised on water-soluble polymers by means of ionising radiation - flow of accelerated electrons with energy 2.5 MeV, absorbed dose from 2 to 10 kGy and rate of dose gain 1.65 kGy/hour.

EFFECT: medication by claimed invention does not have immunogenicity, is highly efficient both in parenteral and peroral introduction.

10 tbl, 10 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, namely to pharmacology. An agent represents an aqueous solution of molecularly capsulated dihydroquercetin in the form of a water-soluble associate. Dihydroquercetin is homogenised in a melted surfactant or in a general solvent ethanol in the relation of the surfactant to dihydroquercetin 5:1 in a temperature range 40-70°C to be mixed with water and concentrated by water evaporation.

EFFECT: invention allows higher bioavailability and activity of the agent, simplified technology.

4 cl, 3 ex, 3 tbl, 8 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry, in particular to medication for treatment of remote effects of poisoning by methemoglobin generators. Medication for treatment of remote effects of poisoning by methemoglobin generators, including dry extract of fruits and seeds of Schisandra (standardised by content of total amount of lignans not less than 2.5%) and cytoflavin, taken in definite ratio.

EFFECT: medication is efficient for treatment of remote effects of poisoning by methemoglobin generators.

6 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine. Mixture consists of medicinal plants: inflorescences of pot marigold, peppermint leaves, Baikal skullcap root, black leaves and root of badan, shoots of shrubby cinquefoil, with the following component ratio, wt fr.: inflorescences of pot marigold 3; peppermint leaves 1; Baikal skullcap root 2; rhizome and black leaves of badan - 1+1; shoots of shrubby cinquefoil 2. Clinical treatment with claimed mixture has resulted in positive effect in case of alcoholic hepatitis in 150 patients.

EFFECT: creation of mixture for treatment and prevention of alcoholic hepatitis.

10 tbl

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine. Mixture consists of medicinal plants: inflorescences of pot marigold, peppermint leaves, Baikal skullcap root, black leaves and root of badan, shoots of shrubby cinquefoil, with the following component ratio, wt fr.: inflorescences of pot marigold 3; peppermint leaves 1; Baikal skullcap root 2; rhizome and black leaves of badan - 1+1; shoots of shrubby cinquefoil 2. Clinical treatment with claimed mixture has resulted in positive effect in case of alcoholic hepatitis in 150 patients.

EFFECT: creation of mixture for treatment and prevention of alcoholic hepatitis.

10 tbl

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine. Mixture consists of medicinal plants: inflorescences of pot marigold, peppermint leaves, Baikal skullcap root, black leaves and root of badan, shoots of shrubby cinquefoil, with the following component ratio, wt fr.: inflorescences of pot marigold 3; peppermint leaves 1; Baikal skullcap root 2; rhizome and black leaves of badan - 1+1; shoots of shrubby cinquefoil 2. Clinical treatment with claimed mixture has resulted in positive effect in case of alcoholic hepatitis in 150 patients.

EFFECT: creation of mixture for treatment and prevention of alcoholic hepatitis.

10 tbl

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine. Mixture consists of medicinal plants: inflorescences of pot marigold, peppermint leaves, Baikal skullcap root, black leaves and root of badan, shoots of shrubby cinquefoil, with the following component ratio, wt fr.: inflorescences of pot marigold 3; peppermint leaves 1; Baikal skullcap root 2; rhizome and black leaves of badan - 1+1; shoots of shrubby cinquefoil 2. Clinical treatment with claimed mixture has resulted in positive effect in case of alcoholic hepatitis in 150 patients.

EFFECT: creation of mixture for treatment and prevention of alcoholic hepatitis.

10 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to chemical-pharmaceutical industry, namely to creation of composition of dense extract of conifer needles for capsulation. Composition of dense extract of conifer needles contains the following ingredients: dense extract of conifer needles, emulsifier, a-tocopherol (vitamin E), retinol (vitamin A), naphthoquinones (vitamin K), essential fatty acids (vitamin F), vegetable oil. Microelements can be included additionally.

EFFECT: composition improves state of mucous membranes and enhances protective properties of organism.

2 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of pharmacology, medicine and food industry and deals with medicine for reduction of visceral fatty tissue accumulation, which contains compounds of formula or extract of plant Liliaceae, which includes these compounds, application of said compounds or extracts for inhibition of visceral fatty tissue accumulation as well as product on their basis.

EFFECT: invention insures efficient reduction of visceral fatty tissue accumulation.

19 cl, 2 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of pharmacology, medicine and food industry and deals with medicine for reduction of visceral fatty tissue accumulation, which contains compounds of formula or extract of plant Liliaceae, which includes these compounds, application of said compounds or extracts for inhibition of visceral fatty tissue accumulation as well as product on their basis.

EFFECT: invention insures efficient reduction of visceral fatty tissue accumulation.

19 cl, 2 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to veterinary and can be used for external application in treatment of dogs, cats, fur-bearing animals and other small pets with disease of bacterial-mycotic-mite etiology. Cream for treatment of skin disease of small pets, contains acaricidic, anti-mycotic-antimicrobial substances, wt %: 20% Roksacin 1.8-2.1; 1% Aversect-2 7.8-8.1; child's cream on grease base - the remaining part.

EFFECT: invention insures increasing of efficiency and reduction of treatment terms.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to urology and rehabilitation medicine, and deals with prevention and complex treatment of urolithiasis after distant lithotripsy. For this purpose after distant-shock-wave lithotripsy carried out is litholytic, antibacterial, antispasmodic, analgesic therapy with administration of a diet. Additionally introduced is infusion of medicinal plants, which contains bearberry leaves, leaves of Indian kidney tea, knotweed grass, dill fruits, burdock root, nettle leaves, rowan fruits, taken in equal component ratio. Infusion is introduced in dose 100 ml 3 times for day 30 min before meal for 10 days at the background of carried out basic therapy and for 4 weeks after its withdrawal, basic therapy.

EFFECT: method ensures efficient prevention and treatment due to complex impact on all links of urolithiasis pathogenesis.

3 cl, 1 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry, in particular to medication for treatment of remote effects of poisoning by methemoglobin generators. Medication for treatment of remote effects of poisoning by methemoglobin generators, including dry extract of fruits and seeds of Schisandra (standardised by content of total amount of lignans not less than 2.5%) and cytoflavin, taken in definite ratio.

EFFECT: medication is efficient for treatment of remote effects of poisoning by methemoglobin generators.

6 tbl, 4 ex

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