Compound containing n-heteroaryl residue bound with condensed cyclic residues for nad(p)h-oxidase inhibition and thrombocyte activation

FIELD: medicine, pharmaceutics.

SUBSTANCE: described are new compounds of general formula (I): het-X-AB (I) where het is pentamerous N-heteroaryl, additionally containing one O, S or N atom as a heteroatom with heteroaryl with additional O atom being condensed with a benzene ring, or hexamerous N-heteroaryl; X means S; and where N-atom of N- heteroaryl residue and an X group are separated by one carbon atom; AB means 1,2,3-triazolo[4,5-d] pyrimidine-7-yl radical of general formula (II): where R3 is C1-8alkyl, phenyl, benzyl optionally substituted; R5-H, C1-8alkyl or phenyl.

EFFECT: production of new compounds for preparing a pharmaceutical composition either effective for treating cardiovascular, cancer, autoimmune diseases, stroke, neurodegenerative diseases, cystic fibrosis, or used in antithrombotic therapy.

9 cl, 11 ex, 3 tbl

 

The invention relates to compounds containing N-heteroaryl residue, which is bound through oxygen, sulfur or nitrogen, or via a methylene bridge and the oxygen, sulfur or nitrogen condensed cyclic residue, and to their use in medicinal products for the treatment of diseases associated with NAD(P)H-oxidase and inhibition of platelet activation. In particular, this invention relates to 1,2,3-triazolo[4,5-d]pyrimidine compounds, where N is a heteroaryl residue linked through oxygen, sulfur or nitrogen, or via a methylene bridge and the oxygen, sulfur or nitrogen with triazolopyrimidines balance. This invention also relates to a method for producing the above compounds.

NAD(P)H oxidase (NOX) are composed of many subunits of the enzymes that generate superoxide and other reactive oxygen species (ROS) from oxygen. NAD(P)H-oxidase consist of membrane-bound catalytic part, homologues of NAD(P)H-oxidase, which contain all prosthetic group required for electron transfer from NADPH to oxygen, whereby is produced by superoxide. Despite the importance of ROS in the regulation of basic physiological processes, the production of ROS can cause oxidative stress, which is an important causal factor in the origin about which rassasavanii chronic degenerative diseases, such as diseases of the cardiovascular system. While in the middle of physiological concentrations of ROS are regulatory molecules, their production can lead to many defects and the absence of regulation, if it is the timing and the amount is not precisely regulated. An important consequence of the formation of ROS in cells of the vascular system is the absorption of nitric oxide (NO). NO inhibits the development of diseases of the vascular system and NO loss is significant in the pathogenesis of cardiovascular diseases.

Thus, ROS generated due to the impact of NAD(P)H-oxidase contribute to the pathogenesis of numerous diseases, particularly cardiovascular diseases or disorders associated with endothelial dysfunction, including, but without limitation, hypertension, atherosclerosis, cardiac hypertrophy, heart failure, restenosis, diabetes, and angina. Other diseases and disorders associated with increased activity of NAD(P)H-oxidase, are, among others, various chronic inflammatory diseases, neurodegenerative diseases, including Alzheimer's disease, bronchial asthma, damage during reperfusion, renal disease, cancer, arthritis and pulmonary hypertension. In these and other pathological conditions NAD(P)H oxidase is the predominant light source is com ROS and activation of these enzymes leads to many intracellular signaling events, which, in the end, cause dysfunction of endothelial cell proliferation, the expression of proinflammatory genes and reconstruction of the extracellular matrix.

In WO 04/005267-Al disclosed substituted heteroaryl and heterocyclic compounds, which are suitable for treating or reducing the intensity of symptoms mediated by reactive species of oxygen (ROS). The above compounds are substituted five-membered cycles heteroanalogues type.

In WO 01/36421 disclosed l,2,3-triazolo[4,5-d]pyrimidine compounds that are substituted at the C-7 amino groups. The above compounds can act as inhibitors of platelet activation, which is induced by adenosine-5'-diphosphate (ADP). The above compounds possess antimicrobial activity.

Other 1,2,3-triazolo[4,5-d]pyrimidine compounds disclosed in the following documents:

In the European patent 0201289 disclosed derivatives of 5-amino-7-halogen-1,2,3-triazolo[4,5-d]pyrimidine with antiviral activity.

In the Japan patent 59062594 and 59062595 disclosed derivatives of 3-phenyl-1,2,3-triazolo[4,5-d]pyrimidine, which are substituted at C-5 and C-7 halogen, alkoxy, alkylthio-, amino group and which have antitumor activity.

In the Japan patent 56131586 and 56131587 disclosed derivatives of 5H-3-phenyl-l,2,3-Tria the olo[4,5-d]pyrimidine, which are substituted at C-7 by cyano, tolilsulfonil, alkoxyl, fenoxaprop, hydratherapie etc. that have antitumor activity.

3-[(4-Chlorophenyl)methyl]-7-[4-(2-propenyl)-5-(4-pyridinyl)-1,2,4-triazole-3-yl]thio]-1,2,3-triazolo[4,5-d]pyrimidine (registration number on Caplus 499140-86-2), 3H-1,2,3-triazolo[4,5-d]pyrimidine-7-amine-3-[(4-forfinal)methyl]-N-2-pyridinyl-(9CI) (registration number on Caplus 255370-07-1) and 3H-1,2,3-triazolo[4,5-d]pyrimidine-7-amine-3-[(2-forfinal)methyl]-N-2-pyridinyl-(9CI) (registration number on Caplus 255369-94-9) is already known.

The present invention is to obtain new active agents that focus on NO-signaling cascade and its equivalent NAD(P)H-oxidase (MOX)as strong inhibitors of NOX have significant clinical potential for the prevention and treatment of a wide range of diseases and disorders.

This task can be achieved using the compounds of General formula (I):

,

where

het means a five-membered or six-membered N-heteroaryl or condensed five-membered or six-membered N-heteroaryl;

X is O, S, NR7and R7selected from R3;

and where the nitrogen atom of the N-heteroaryl residue and the group -(CH2)n-X are separated by one carbon atom;

AB means 1,2,3-triazolo[4,5-d]pyrimidine-7-yl General form is s (II):

where R3means hydrogen; alkyl; cycloalkyl; aryl; aralkyl; alkenyl; cycloalkenyl; quinil; and alkyl, cycloalkyl, aryl, aralkyl, alkenyl, cycloalkenyl, quinil may contain one or more elements selected from the group consisting of O, S, N, halogen (F, Cl, Br, I); and

R5means hydrogen; halogen (F, Cl, Br, I); HE; R3-S; R3-About; NR1R2where R1and R2independently from each other, means R3or where R1and R2together form a cyclic system; het-(CH2)n-X, where het, n and X have the above meaning;

or their pharmaceutically acceptable salts or MES or MES such salt;

provided that excluded 3-[(4-chlorophenyl)methyl]-7-[4-(2-propenyl)-5-(4-pyridinyl)-1,2,4-triazole-3-yl]thio]-1,2,3-triazolo[4,5-d]pyrimidine (registration number on Caplus 499140-86-2), 3H-1,2,3-triazolo[4,5-d]pyrimidine-7-amine-3-[(4-forfinal)methyl]-N-2-pyridinyl-(9CI) (registration number in Caplus 255370-07-1) and 3H-1,2,3-triazolo[4,5-d]pyrimidine-7-amine-3-[(2-forfinal)methyl]-N-2-pyridinyl-(9CI) (registration number on Caplus 255369-94-9).

The term "N-heteroaryl" refers to an aromatic five - or six-membered carbocyclic system containing at least one carbon atom substituted by a nitrogen atom. The above term also refers to the possible tautomeric forms of the above tsiklichyeskimi. For example, 2-hydroxypyrimidinone system can be represented in the tautomeric form 1H-2-exosystem.

The above nitrogen atom N-heteroaryl residue and the group -(CH2)n-X are separated by one carbon atom, which means that N-heteroaryl residue substituted by the above group vicinal to the above nitrogen atom.

According to other embodiments can be replaced by other carbon atoms in the above-mentioned N-heteroaryl residue other heteroatoms, preferably nitrogen atoms, oxygen or sulfur.

Preferably, five-membered N-heteroaryl are imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolin, triazolyl, oxadiazolyl, thiadiazolyl, tetrazolyl, oxadiazolyl, tetrazolyl, which may be substituted with hydrogen and/or other substituents, preferably those that are listed below.

Particularly preferred are imidazolyl, oxazolyl, thiazolyl.

Preferably, six-membered N-heteroaryl are pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, which may be substituted with hydrogen and/or other substituents, preferably those that are listed below.

Particularly preferred is pyridinyl, pyrimidinyl.

In addition, the N-heteroaryl residue may be condens the Rowan with alicyclic, aromatic or heteroaromatic system, and the resulting system can be replaced by hydrogen and/or other substituents, preferably those that are listed below.

According to one embodiment of the five-membered N-heteroaryl condensed with an aromatic system.

Preferably, the above-mentioned aromatic system is benzoicum. The resulting five-membered N-heteroaryl systems include benzimidazolyl, benzoxazolyl, benzothiazolyl.

Heteroaromatic systems, which may be condensed five-membered N-heteroaryl are, for example, pyridine, quinoline, benzothiazole.

If, for example, 1,2,4-triazole fused with pyridine, quinoline, benzothiazole, it is possible to obtain, for example, condensed radicals 1,2,4-triazolo[4,3-a]pyridine-3-yl, 1,2,4-triazolo[4,3-a]quinoline-3-yl and 1,2,4-triazolo[3,4-b]benzothiazole-3-yl.

According to another embodiment of the six-membered N-heteroaryl condensed with an aromatic system.

Preferably, the above-mentioned aromatic system is benzoicum. The resulting six-membered N-heteroaryl system include chinoline and ethenolysis.

Other aromatic system, which may be condensed five - or six-membered N-heteroaryl include pyridine system and pyrimidine system.

Friend the first aspect according to this invention relates to the compound of General formula (I), where one or more hydrogen atoms five-membered or six-membered N-heteroaryl residue, or a condensed five-membered or six-membered N-heteroaryl residue can be, independently of one another, substituted by one or more radicals R3.

The term "alkyl" refers to saturated linear or branched carbon chain. Preferably, the chain comprises from 1 to 8 carbon atoms.

The term "cycloalkyl" refers to a saturated monocyclic or bicyclic residue. Preferably, monocyclic system consists of 3-8 carbon atoms, and bicyclic system consists of 9-10 carbon atoms. Particularly preferred is a monocycle with the number of carbon atoms from 3 to 6. Examples are cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.

The term "aryl" preferably refers to an aromatic monocyclic residue containing 6 carbon atoms, an aromatic bicyclic system containing 10 carbon atoms, or an aromatic tricyclic system containing 14 carbon atoms. Examples are phenyl, naphthalenyl or anthracene.

The term "aralkyl" refers to an alkyl residue, which is substituted by aryl, where alkyl and aryl have the above significance. An example is the benzyl radical.

The terms "alkenyl" and "cycloalkenyl" about the rush to olefinic unsaturated containing atoms of carbon chains or cycles with one or more double bonds. Examples are propanil and cyclohexenyl.

The term "quinil" refers to unsaturated containing atoms of carbon chains or cycles with one or more triple bonds. An example is propargyl.

According to one embodiment of the carbon atoms or the hydrogen atoms in alkyl, cycloalkyl, aryl, kalkilya, alkenyl, cycloalkenyl, etkinlik radicals can be, independently of one another, substituted by one or more elements selected from the group consisting of O, S, N, or groups containing one or more elements selected from the group consisting of O, S, N.

Embodiments include alkoxy, cycloalkane, aryloxy, Alcoxy, alkenylacyl, cycloalkenyl, alkyloxy, alkylthio, cycloalkyl, aaltio, Uralkali, alkanity, cycloalkenyl, alkylthio, alkylamino, cyclooctylamine, arylamino, aralkylamines, alkenylamine, cyclooctylamine, alkylamidoamines.

Other embodiments include hydroxyalkyl, hydroxycyclohexyl, hydroxyaryl, hydroxyalkyl, hydroxyalkyl, hydroxycyclohexanone, hydroxyalkenals, mercaptopurine, mercaptopurine, mercaptopurine, mercaptopurine, mercaptoquinoline, mercaptocysteine, mercaptoquinoline, aminoalkyl, aminocyclohexane, aminoaniline, amino is alkylene, aminoacridine, aminocyclohexanone, aminoalkyl radicals.

According to one embodiment, where one or more carbon atoms, carbocyclic system replaced/substituted by one or more heteroatoms, forms a heterocyclic radical. The term "heterocyclyl" preferably refers to a saturated or partially unsaturated five-membered cycle, at least one member of which is an atom of N, O or S and which optionally contains one additional atom On one or additional N atom; a saturated or partially unsaturated six-membered cycle, at least one member of which is an atom of N, O or S and which optionally contains one additional atom On one or additional N atom, or two additional N atom; or a saturated or partially unsaturated deletechannel or deletechannel bicyclic residue, at least one member of which is an atom is N, O or S and which optionally contains one, two or three additional atom N. Heterocyclic group optionally substituted. Examples include, but are not limited to, pyrrolyl, pyrrolidinyl, imidazolyl, imidazolidinyl, pyrazolyl, pyrazolidine, piperidine, morpholine or piperazinil.

According to another embodiment of the hydrogen atoms in alkyl, cycloalkyl is inih, aryl, kalkilya, alkenyl, cycloalkenyl, etkinlik the radicals can be substituted, independently of one another, by one or more halogen atoms. One radical is trifluoromethyl.

If two or more radicals may be chosen independently from each other, then the term "independently" means that the radicals may be the same or may be different.

Aspects according to the present invention include compounds of General formula (I), where R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, N 1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from the group consisting of H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Other aspects in accordance with this invention include compounds of formula (I)where the substituents of het in the residue het-(CH2)nX is chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains up to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Further aspects in accordance with this invention include compounds of General formula (I), where n is 0 and X is O, S or NR7.

Further aspects in accordance with this invention include compounds of General formula (I), where n is 1 and X is O, S or NR7.

Preferred embodiments according to this invention include compounds of General formula (I), where n means 0 or 1 and X is S.

Other preferred embodiments according to this invention include compounds of General formula (I), where n is 1 and X is O or NR7.

Another aspect according to this invention includes compounds of General formula (I), where R3means benzyl radical which may be substituted. Preferably, R3means of CH2-phenyl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1 and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Still further aspects according to this invention include compounds of General formula (I), where R5selected from hydrogen, NH2, (C1-8)alkyl, (C3-6)cycloalkyl, benzyl, phenyl, preferably hydrogen, NH2, (C1-8)alkyl, benzyl, phenyl.

According to one aspect of the present invention includes compounds of General formula (I), where het means a substituted five-membered N-heteroaryl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of toroda, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of General fo the formula (I), where het means a substituted five-membered N-heteroaryl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, hetaeras is aryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of General formula (I), where het means a substituted five-membered N-heteroaryl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6choose from GRU the dust, consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes the soedineniya formula (I), where het means a substituted imidazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-81R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R 2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where the substituents is ybiraut, independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-and the sludge, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted oxazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)and the Kyl-R 4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where the substituents chosen, independently on the UGA, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5 )alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R 4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted isoxazolyl, where the substituents chosen independently from each other, from the group, with the standing of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-52-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted isoxazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)qi is loukil-R 4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted isoxazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)t is kloeckera, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2/sub> , -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted thiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)al the Il-R 4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, FeNi is a, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -the O-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4 ), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted isothiazole, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl is, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1The R 2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted isothiazole, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted isothiazole, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-Goethe is of aurila, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently researched the Simo selected from N, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted triazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4),(C 1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by atoms O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted triazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1 R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl which, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted triazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8 )alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted oxadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R21-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl, and what and where R 1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted oxadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4that gets recycler-R 4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted oxadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-N 1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2the place form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted thiadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4, heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted thiadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)Alki is a, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated angle is the same circuit, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted thiadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted tetrazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5 )alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which content is t from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted tetrazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group of the s, consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains at to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted tetrazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7wybir the t of R 3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at the ore one carbon atom may be replaced by Oh, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted oxadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C18 )alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted oxadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6 is chosen from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes the t of the compounds of formula (I), where het means a substituted oxadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocy is Lila, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted tetrazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8 )alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het about the means substituted tetrazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-Goethe is of aurila, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted tetrazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR 1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted five-membered N-heteropar is l, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-het is of roarie, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted five-membered N-heteroaryl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8 )alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted five-membered N-heteroaryl, where the substituents you het eraut, independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-and the sludge, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted imidazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)is lcil-R 4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where the substituents chosen independently from the other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5 )alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-Rsub> 4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted oxazolyl, where the substituents chosen independently from each other, from the group, SOS is oasa from hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-52-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycle is alkyl-R 4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)CEC is valkila, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2/sub> , -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted isoxazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R 4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted isoxazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, Anila, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -the O-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted isoxazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R 4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted thiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl is a, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1The R 2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S((C 3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -N 1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independent is selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted isothiazole, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R41-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted isothiazole, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1/sub> R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxy, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, the Rila, or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted isothiazole, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)and the Kyl-R 4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted triazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5of alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxy, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2 together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted triazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxy, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted triazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R , -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2along the way who are rich, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted oxadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4 heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted oxadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)al the sludge, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated angle is the same circuit, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het substituted by oxadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R 4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted thiadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 on the 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted thiadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from GRU the dust, consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted thiadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7the choice is up from R 3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at the ore one carbon atom may be replaced by Oh, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted tetrazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8 )alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted tetrazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6you who eraut from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes the t of the compounds of formula (I), where het means a substituted tetrazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocycle is a, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted oxadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1- )alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het oz is achet substituted oxadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-Goethe is of aurila, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted oxadiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR 1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted tetrazolyl, where the Deputy shall choose Fort worth, independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, CONR 1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted tetrazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-heteroaryl-R 4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted tetrazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen,-F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-( 1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted condensed five-membered N-heteroaryl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4 ), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted condensed five-membered N-heteroaryl, where the substituents choose, regardless what about from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5 )alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted condensed five-membered N-heteroaryl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C 1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where the substituents are chosen, n is independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C-5 )alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -N(heterocyclyl-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF 3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O) -(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R43-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3,(C 1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2 , -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-(C 3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8of alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5 )alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted condensed benzothiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C 1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5 )alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted condensed five-membered N-heteroaryl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4 ), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted condensed five-membered N-heteroaryl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8 )alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-C-(C 1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted condensed five-membered N-heteroaryl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heteros who was cilil-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF , (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R 2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S((C 1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl is, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2/sub> , -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8 )alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, Goethe is Ollila, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)and the Qila, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4 ), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl,aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-Ari is a; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(Goethe is iillil-R 4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl,-O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently researched the Simo selected from N, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted six-membered N-heteroaryl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)qi is loukil-R 4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted six-membered N-heteroaryl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR 1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3- )cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted six-membered N-heteroaryl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-(C 3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted pyridinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR 1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6/sub> )cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4(C 3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl,-S(O) 2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxy, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, FeNi is a, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl the-R 4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5 )alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form the rich, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4heterocy the Lil-R 4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted pyridazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1 R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially nenas the seal or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted pyridazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 is the", independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted pyridazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is appoints NR 7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 the volume of carbon where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted 1,2,3-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group of the s, consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted 1,2,3-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5ezavisimo choose from (C 0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted 1,2,3-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH,-CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted 1,2,4-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)al the ilen-R 6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspectarian present invention includes compounds of formula (I), where het means a substituted 1,2,4-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8/sub> )alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted 1,2,4-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C 1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het substituted 1,3,5-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteros is aryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted 1,3,5-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4 ), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted 1,3,5-triazinyl, where the substituents chosen independently from others who ha from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted six-membered N-heteroaryl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R 4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted six-membered N-heteroaryl, where the substituents het choose, not avisio from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5 )alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted six-membered N-heteroaryl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R 4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted pyridinyl, where the substituents chosen independently from each other is a, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxy, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5 )alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(gets recycler-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF31-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-( 1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C 3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-83-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5 )alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cyclo is lcil-R 4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted pyridazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)CEC is valkila, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -With The-O-(C 1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted pyridazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(Goethe is oail-R 4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted pyridazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)ALCO is power, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-is-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted 1,2,3-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(hetero is iklil-R 4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by atoms O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted 1,2,3-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-the Rila, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C )alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted 1,2,3-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4, -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted 1,2,4-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteros is aryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (Csub> 3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted 1,2,4-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)R 4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted 1,2,4-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C-5 )alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)t is kloeckera, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted 1,3,5-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)t is cloaker-R 4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted 1,3,5-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5 )alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form the rich, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted 1,3,5-triazinyl, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4heteros CLIL-R 4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted condensed six-membered N-heteroaryl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-C 1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together clicks the form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted condensed six-membered N-heteroaryl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-Rsub> 4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted condensed six-membered N-heteroaryl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxy, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-C 1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, Ari is a, or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted chinoline, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted chinoline, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)Alki is a, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form the feast upon the lamb partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted chinoline, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4heterocy the Lil-R 4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted ethenolysis, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR 1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially n is saturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted ethenolysis, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxy, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 C is the election agent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted ethenolysis, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; the X is NR 7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 the volume of carbon where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted condensed six-membered N-heteroaryl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 Deputy who, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted condensed six-membered N-heteroaryl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)al the sludge, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 on the 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted condensed six-membered N-heteroaryl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxy, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R 4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted chinoline, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)and the Qila, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 on the 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted chinoline, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from groups who, consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted chinoline, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7the choice is up from R 3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at the ore one carbon atom may be replaced by Oh, S or N.

According to one aspect of the present invention includes compounds of formula (I), where het means a substituted ethenolysis, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8/sub> )alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes compounds of formula (I), where het means a substituted ethenolysis, where the substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R3and R5independently selected from (C0-8)alkylene-R6where R6ybiraut from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another aspect according to this invention includes the t of the compounds of formula (I), where het means a substituted ethenolysis, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, hetero is Lila, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of in Dorada, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes the compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (Csub> 1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (the 1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes soybean is inane formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C )alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alcox the La, HE, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where he means substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-het is of roarie, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R , -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl where het substituents chosen independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C )alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, which will replace the if het is chosen, independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2 , -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4) -NH-(aryl-R 4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently on the angle from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where the substituents het is chosen, n is independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, --(C 1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4 ), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen independently from others who ha from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C-5 )alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4 ), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of the others is g from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1Rsub> 2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4, -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where the substituents het choose the, independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2 , -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4 ), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where the substituents het the choice is up, independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R 2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2 , -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzamides is poured, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R , -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where the substituents het choose independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, CONR 1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)al the Il-R 4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents in baraut, independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-(C 1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where zamestitel het choose independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2 , -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4) -NH-(aryl-R 4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently on the angle from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where the substituents het is chosen, n is independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, --(C 1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4 ), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently from each other is a, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C-5 )alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4 ), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of the other the other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1Rsub> 2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4),-NH-(aryl-R 4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where the substituents het choose Nezavisimaja from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 0; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-C 1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(hetero is the Rila-R 4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another, from the group, with Toyama from hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(Csub> 1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R 4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another, from the group, with Toyama from hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C )alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heteros who was cilil-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, NO 2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O) -NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4 ), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C-5 )alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(GE is eroticly-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -C, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -H,-((C 3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2 , -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)sub> 2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(hetero CLIL-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl,-OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)is Lila, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocycle the-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -N, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -SO) 2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocycle the-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F,- Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-C 1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R44), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another, from the group, SOS is oasa from hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C-5 )alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterotic the Il-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen,- F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C )alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R 4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another, from the GRU is dust, consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(GE is Eroare-R 4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of one another, from the group, SOS is oasa from hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-52-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(Goethe is iillil-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2 -(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R 4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of each other, of the group is s, consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)is Lila, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently from one another from the group comprising the her from hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(Csub> 1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R 4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another, from the group, with the standing of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C )alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(Goethe is iillil-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN,- NO 2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O) -NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R ), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH,- CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C-5 )alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(g is eroticly-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, F, Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is S; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -N((C 3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO23, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O) 2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocy the Lil-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -H, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)is Lila, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocycle the-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, NO 2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2 -NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4/sub> ), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5 )alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(g is eroticly-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -C, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-52-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), NH-((C 3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2 , -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O 2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(hetero CLIL-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl,-OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)is Lila, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocycle the-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -N, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -(O) 2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocycle is l-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F,- Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2 1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4 ), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another, from the group, with Toyama from hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5 )alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterotic the Il-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen,- F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C 1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(hetero is the Rila-R 4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another, from the GRU is dust, consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-52-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(g is tetraaryl-R 4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of one another, from the group, SOS is oasa from hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5 )alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4) -NH-(heterocyclyl-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2/sub> -(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-Rsub> 4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of each other, of the group is s, consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5of alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R44), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently from one another from the group comprising the her from hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-( 1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-Rsub> 4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another, from the group, with the standing of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C 1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -N(heterocyclyl-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN,- NO 2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2 -NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4 ), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH,- CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5 )alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R 4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, F, Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is O; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-52-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl the-R 4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another, from the group, with Toyama from hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R 2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NRsub> 1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4has 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where the substituents het choose independently from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl which, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted thiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen,(C 1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes joint is of the formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterotic the sludge, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5mean NH2; and R3choose from (C0-8)alkylen- 6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preference for the equipment of the embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cyclol the sludge, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means benzyl; and R3choose from (C0- )alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

D. the natives preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted imidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, courtesans who were tilila, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means H; and R3choose from (C0-8)alkylene-R6where R selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodied is giving according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, gets Roccella, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means (C1-8)alkyl; and R3choose from (C0-8)al the ilen-R 6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preference for the equipment of the embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, courtesans who were tilila, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted oxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means phenyl; and R3choose from (C0-8)alkylene-R6/sub> where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Preferred is opasenie according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, hetero is Lila, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5mean NH2; and R3choose from (C0-8)alkyl is n-R 6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preference for the equipment of the embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cyclo is Lila, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means benzyl; and R3choose from (C )alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

D. the natives preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzothiazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, gets Roccella, phenyl, aryl, heteroaryl, (C1-8)alkoxy, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means H; and R3choose from (C0-8)alkylene-R6, R 6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred in padenie according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl is, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means (C1-8)alkyl; and R3the choice is up from (C 0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from gr is PPI, consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzimidazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X Osnach the em NR 7and R7selected from R3; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 is about 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4depict is to place a 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -With The-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated coal is native circuit, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4that Fe is Il-R 4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -SO) 2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted benzoxazolyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4 ), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1 2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independent wybir the t from N, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(hetero is the Rila-R 4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, hetaeras is aryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -OCO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6 )cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyridinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF 3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means phenyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S() 2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

A preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means H; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(and the Il-R 4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where the substituents het choose Nezavisimaja from each other, from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5mean NH2; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl is a, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means (C1-8)alkyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, HE, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (a), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means benzyl; and R3choose from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, gets Roccella, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Another preferred embodiment according to this invention includes compounds of formula (I), where het means a substituted pyrimidinyl, where het substituents chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and n is 1; and X is NR7and R7selected from R3; and R5means phenyl; and R3choose from (C0-8)alkylene-R 6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH-((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5) alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

In addition, ar is as or more of the crystalline forms of the compounds of General formula (I) may exist as polymorphs. Assume that such forms are within the scope of the present invention. In addition, some of the compounds may form a solvate with water (i.e. hydrates) or common organic solvents, and imply that such a solvate is included in the scope of the present invention.

Still another object of this invention is a method of obtaining compounds of General formula (I), according to which the compound of General formula (III) enter into interaction with the compound of General formula (IV):

where het-X and AB have the above value, N denotes a hydrogen atom and Y represents a leaving group.

Preferably, Y represents halogen or organic sulfentrazone.

Preferably, the halogen means chlorine or bromine.

Preferred sulfentrazone include methanesulfonate, p-methylphenylsulfonyl or triftormetilfullerenov.

The reaction of compounds of General formula (III) with a compound of General formula (IV) can be carried out in accordance with methods commonly used in organic chemistry.

Preferably, the reaction is carried out using a solvent in which the compound of General formula (III) and the compound of General formula (IV), preferably at least partially soluble. Suitable solvents which are polar, nonpolar, proton and aprotic organic solvents, among other things, chlorohydrocarbons with the number of carbon atoms up to three, such as dichloromethane, NITRILES such as acetonitrile, esters such as ethyl acetate, ketones such as methyl ethyl ketone or acetone, with an open-chain or cyclic ethers, such as tetrahydrofuran or dioxane, or an aromatic compound such as toluene or xylenes, formamide, such as dimethylformamide, sulfoxidov, such as dimethylsulfoxide, ethers such as diethyl ether, hydrocarbons, such as hexane or cyclohexane, or a mixture of two or more of these solvents.

If compounds have low solubility, can be used interphase catalysts.

The reaction can be carried out in a wide temperature range. Can be used range from -20aboutC to the boiling temperature under reflux of the solvent.

During the interaction of the compounds of General formula (III) and compounds of General formula (IV) is formed acid HY. Depending on nucleofuge the above acid is a halogen acid or acid. To increase the speed of the reaction, preferably, the above acid is neutralized with base. Bases are, for example, sodium carbonate, hydroc rbonate sodium, the triethylamine and the like by using the above reason, in the reaction time of the Foundation of the obtained salt and formed nucleofug. Usually the above salt is insoluble in the solvent and precipitates.

Typically, the target compound is soluble in the solvent. Then the above salt is removed by filtration or extraction with water. The solvent is removed and the crude solid target compound can be purified, for example, by recrystallization or conventional chromatographic methods.

If the target compound is insoluble in the solvent, it preferably emit by filtration, and then the inorganic or organic salt is removed by extraction with water and then the residue purified as described above.

Compounds of General formula (III) are known or can be obtained in accordance with known methods or by modifying known from the literature ways of getting.

Compounds of General formula (IV) are also known or can be obtained in accordance with known methods or by modifying known from the literature ways of getting.

Examples of monocyclic compounds of General formula (III), where n means 0 (het-X-H)are 2-mercaptothiazole, which can be obtained by reacting the corresponding bromo derivatives with thiourea in methanol at Kip the treatment under reflux (G. Biagi, Giorgi I., Livi O., Pacchini F., Scartoni V., J. Heterocycle Chem.,39, 885 (2002)); or a derivative oxazole, which can be obtained from the dimer of glyoxalase in acetonitrile by entering into interaction with titanoboa acid (WO 03/006442).

Examples benzododecinium compounds of General formula (III), where n means 0 (het-X-H)are commercially available 2-mercaptopyridine, 2-mercaptobenzoxazole and 2-mercaptoimidazole. For example, 2-mercaptobenzimidazole can be obtained by reacting aniline, carbon disulfide and sulfur (registration number CAS 149-30-4).

Example monocyclic compounds of General formula (III), where n means 1 (het-CH2-X-H)is 2-hydroxymethylimidazole, which can be obtained by reacting imidazole with formaldehyde (Journal of Organic Chemistry,40(12), 1837-1838 (1975)).

Example benzododecinium compounds of General formula (III), where n means 1 (het-CH2-X-H)is 2-mercaptobenzothiazol, which can be obtained by reacting 2-chloromethylthiazole with thiocarbonates sodium (Synthetic Communication,33(9), 1433-1442 (2003)).

Compounds of General formula (IV) are also known or can be obtained in accordance with known methods or by modifying known from the literature ways of getting.

For example, triazolopyrimidine General formula (IV) with benzyl radical in image quality is as the values of R 3and hydrogen as the values of R5in which Y represents chlorine, can be obtained according to the following General method: benzylbromide enter into interaction with sodium azide in dimethyl sulfoxide at room temperature, receiving azide. Azide, which can be used as raw substances enter into interaction with cyanoacetamide and sodium ethylate in ethanol by boiling under reflux, getting 4 formamido-5-amino-1-benzylamino-1,2,3-triazole, which may be isolated or in situ entered into reaction with ethyl formate in the formation of triazolopyrimidine. Subsequent introduction into interaction with thionyl chloride leads to a chlorine-containing compound. Such products are disclosed in the documents of the prior art.

Compounds of General formula (IV), substituted, for example, methyl or phenyl radical as the values of R5can be obtained using the same reaction method as described above. The use of ethyl esters of acetic acid or benzoic acid instead of ethylformate leads to the corresponding triazolopyrimidines.

Another example is the synthesis of compounds of General formula (IV) with the amino group as the values of R5. The synthesis of the above amine derivatives described in the literature (Sznaidman M.L., Beauchamp L.M., J. Heterocyclic Chem.,33, 1605-1610 (1996)). 2-Amino-4,6-di is loperamide subject of nitration, receiving 5-nitro-derivatives. Nitrogylcerin very quickly interacts with amines, whereby one atom of chlorine can be selectively replaced. For example, by interacting with benzylamine can be obtained the corresponding 2-amino-4-benzylamino-6-chloro-5-nitropyrimidin. Then the nitrogroup restore, for example, with iron in acetic acid. Then the amino group diasterous that leads to triazolopyrimidine.

Another synthesis of compounds of General formula (IV) with hydrogen as the values of R5in General terms, is as follows: starting from commercially available 4,6-dihydroxypyrimidine his dichloropropane can be obtained by introducing into interaction with POCl3. Then, the above compound is subjected to reaction nitration, receiving his 5-nitro-derivatives. 4,6-dichloro-5-nitropyrimidin very quickly interacts with amines, whereby one atom of chlorine can be selectively replaced. For example, by interacting with p-methoxybenzylamine, phenylamine and o-chlorobenzylamino can be obtained the corresponding 4-aminotoluene-6-chloro-5-nitropyrimidin. Then the nitrogroup restore, for example, with iron in acetic acid. Then the amino group diasterous that leads to triazolopyrimidine.

1,2,3-Triazolo[4,5-d]pyrimidines with AMI who, thio - and axisymmetrically as the values of R5can be obtained from the corresponding halogen-substituted compounds by substitution reaction with the appropriate amines, thiols or oxyconti, whereby remove the halogen. The source material can be 5-halo-1,2,3-triazolo[4,5-d]pyrimidines as disclosed in the documents of the prior art.

The embodiment according to the present invention is the use of the compounds of formula (I) to obtain a pharmaceutical composition or containing medicines to treat or reduce the intensity mediated reactive form of oxygen and is associated with NAD(P)H-oxidase diseases or disorders in a subject in need thereof.

Associated with NAD(P)H-oxidase violation includes cardiovascular diseases and disorders, including, but without limitation, hypertension, atherosclerosis, cardiac hypertrophy, heart failure, restenosis, diabetes, and angina. In addition, other diseases and disorders associated with increased production of superoxide mediated NAD(P)H-oxidase, include, but are not limited to, arthritis, chronic inflammatory intestinal diseases (IBD), sepsis and other inflammatory disorders, asthma, chronic obstructive pulmonary disease (COPD), and acute respi atory distress syndrome (ARDS), cancer, autoimmune diseases, damage during reperfusion, kidney disease, stroke, Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases, cystic degeneration, rejection of organs and pulmonary hypertension.

Mediated reactive species of oxygen (ROS) and inflammatory violation includes, but without limitation, mediated by phosphorylation disorders, mediated by polymorphonuclear leukocytes disorders, mediated by macrophages disorders, mediated by lipopolysaccharide disorders, mediated α-tumor necrosis factor disorders, mediated by the cytokine IFN-γ disorders, mediated by interleukin-2 disorders, inflammatory arthritis caused by peroxochromates potassium arthritis, rheumatoid arthritis, osteoarthritis or Alzheimer's disease.

The embodiment according to the present invention is a method of treating or reducing the intensity mediated reactive species of oxygen (ROS) and associated with NAD(P)H-oxidase (NOX) disorder of a subject, in need thereof, comprising administration to the subject a therapeutically effective amount proposed according to the invention compounds of General formula (I) or containing pharmaceutical compositions.

In the method of treatment or reduction of the intensity above the CSO violations mediated reactive species of oxygen (ROS), the term "reactive oxygen species" includes, but without limitation, reactive oxygen species selected from reactive oxygen species in superoxide, hydrogen peroxide, hydroxyl radical or HOCl.

In addition, it was found that the compound of General formula (I) can inhibit the activation of platelets. The above inhibition may be dependent or independent of the inhibition of NOX.

Preferably, the above-mentioned inhibition is the inhibition induced by thrombin activation of platelets.

The person skilled in the art it is obvious that a therapeutically effective dose of the active compounds according to the invention or comprising their pharmaceutical compositions may vary in accordance with the desired effect. Therefore, the insertion of the optimal dose can be easily determined and can be changed in accordance with specifically used by the connection, by way of introduction, the content of active substance in the medicinal drug and progression of the disease condition. In addition, factors associated with being treated by a specific subject, including the age of the subject, weight, diet and time of administration, can lead to the need to bring the dose to sootvetstvujushchijemu level.

Used therapeutically effective amount proposed according to the invention compounds or enclosing the pharmaceutical composition comprises a dose varying from about 0.001 mg to about 2000 mg, the dose varying from about 0.1 mg to about 500 mg, or dose varying from about 1 mg to about 250 mg, of active ingredient per day for a human (weighing 70 kg).

For oral administration the pharmaceutical composition is preferably provided in the form of tablets containing 0,01, 0,05, 0,1, 1,0, 2,5, 5,0, 10,0, 15,0, 25,0, 50,0, 100, 150, 250 and 500 milligrams of the active ingredient, with the aim of symptomatic installation doses for exposed treatment of the subject.

If the compounds according to the invention or a pharmaceutical composition comprising the compounds according to this invention, have an experimental animal, preferably a rodent, such as the rat, then, preferably, the above experimental animal (weight 500 g) introducing an effective amount of the active ingredient, preferably from 0.014 mg to 3.5 mg

Unexpectedly found that not only compounds of General formula (I) with a particular 1,2,3-triazolo[4,5-d]pyrimidine-7-ilen residue of formula (II)as disclosed above, mainly inhibit NOX and/or platelet activation.

Connections with the remnants of AB, obstvennymi 1,2,3-triazolo[4,5-d]pyrimidine-7-ilen residue, can show the above preferred properties.

The above compounds are responsible of General formula (V):

het-(CH2)n-X-AB(V)

where

het means a five-membered or six-membered N-heteroaryl or condensed five-membered or six-membered N-heteroaryl;

n means an integer and represents 0 or 1;

X is O, S, NR7and R7selected from R3;

and where the N-atom of the N-heteroaryl residue and the group -(CH2)n-X are separated by one carbon atom;

A represents aryl or heteroaryl;

In the mean residue containing five-membered cycle, where the above-mentioned cycle is condensed with A;

R3means hydrogen; alkyl; cycloalkyl; aryl; aralkyl; alkenyl; cycloalkenyl; quinil; and alkyl, cycloalkyl, aryl, aralkyl, alkenyl, cycloalkenyl, quinil contain one or more elements selected from the group consisting of O, S, N, halogen (F, Cl, Br, I);

or their pharmaceutically acceptable salt or MES or MES of such salt.

The term "N-heteroaryl" refers to an aromatic five - or six-membered carbocyclic system containing at least one carbon atom substituted by a nitrogen atom. The above term also relates to the tautomeric forms vysheukazannoe the th cyclic system. For example, 2-hydroxypyrimidinone system can be represented in the tautomeric form 1H-2-exosystem.

The above N-atom of the N-heteroaryl residue and the group -(CH2)n-X are separated by one carbon atom, which means that N-heteroaryl residue substituted by the above group vicinal to the above nitrogen atom.

According to other embodiments can be replaced by other carbon atoms in the above-mentioned N-heteroaryl residue other heteroatoms, preferably nitrogen atoms, oxygen or sulfur.

Preferably, five-membered N-heteroaryl is imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolin, triazolyl, oxadiazolyl, thiadiazolyl, tetrazolyl, oxadiazolyl, tetrazolyl, which may be substituted with hydrogen and/or other substituents, preferably those that are listed below.

Particularly preferred are imidazolyl, oxazolyl, thiazolyl.

Preferably, six-membered N-heteroaryl is pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, which may be substituted with hydrogen and/or other substituents, preferably those that are listed below.

Particularly preferred is pyridinyl, pyrimidinyl.

In addition, the N-heteroaryl residue may be condenser is with an alicyclic, aromatic or heteroaromatic system, and obtained the condensed system can be replaced by hydrogen and/or other substituents, preferably those that are listed below.

According to one embodiment of the five-membered N-heteroaryl condensed with an aromatic system.

Preferably, the above-mentioned aromatic system is benzoicum. The resulting five-membered N-heteroaryl systems include benzimidazolyl, benzoxazolyl, benzothiazolyl, which may be substituted with hydrogen and/or other substituents, preferably those that are listed below.

If, for example, 1,2,4-triazole fused with pyridine, quinoline, benzothiazole, can be obtained, for example, condensed radicals 1,2,4-triazolo[4,3-a]pyridine-3-yl, 1,2,4-triazolo[4,3-a]quinoline-3-yl and 1,2,4-triazolo[3,4-b]benzothiazole-3-yl.

According to another embodiment of the six-membered N-heteroaryl condensed with an aromatic system.

Preferably, the above-mentioned aromatic system is benzoicum. The resulting six-membered N-heteroaryl system include chinoline and ethenolysis.

Other aromatic system, which may be condensed five - or six-membered N-heteroaryl include pyridine system and pyrimidine system.

The next aspect of danagoulian relates to the compound of General formula (V), where one or more hydrogen atoms five-membered or six-membered N-heteroaryl residue, or a condensed five-membered or six-membered N-heteroaryl residue can be, independently of one another, substituted by one or more radicals R3.

In the General formula (V) And represents aryl or heteroaryl that means And represents preferably phenyl, naphthenyl, anthracene or phenyl, naphthenyl, anthracene containing one or more heteroatoms selected from the group consisting of N, O, S.

The five-membered cycle balance is carbocycle or heterocycle. Preferably, the above loop contains one or more heteroatoms selected from the group consisting of N, O, S.

Another aspect of the present invention includes a compound of General formula (V), where the remainder AB is substituted by one or more radicals selected from R3and R5where R3means hydrogen; alkyl; cycloalkyl; aryl; aralkyl; alkenyl; cycloalkenyl; quinil; and alkyl, cycloalkyl, aryl, aralkyl, alkenyl, cycloalkenyl, quinil contain one or more elements selected from the group consisting of O, S, N, halogen (F, Cl, Br, I); and R5means hydrogen; halogen (F, Cl, Br, I); HE; R3-S; R3-O; NR1R2where R1and R2independently from each other, means R3or where R1and R2instead of the e form a cyclic system; het-(CH2)n-X, where het, n and X have the above meaning.

Examples of the residue of AB are the following balances (registration number Caplus cited as an example of compounds containing the above-mentioned residues):

2,1,3-benzoxadiazole-4-yl (662162-64-3); 5H-cyclopent[4,5]thieno[2,3-d]pyrimidine-6-yl (571918-81-5); thieno[2,3-d]pyrimidine-4-yl (561010-33-1); pyrido[1,2-a]benzimidazole-1-yl (571149-57-0); benzothieno[2,3-d]pyrimidine-4-yl (556018-82-7); 5H-cyclopent[4,5]thieno[2,3-d]pyrimidine-4-yl (556018-16-7); 1,3-imidazole[4,5-d]pyrimidine-4-yl (664325-10-4); 1,2,4-triazolo[4,3-a]chinoline (556018-7); 1H-indol-7-yl (548458-07-7); 1,3-dihydro-2H-2-oxopentanoate (548457-72-3); 1,2,4-triazolo[1,5-a]pyrimidine-7-yl (501916-02-5); pyrido-[3',2':4,5]thieno[2,3-d]pyrimidine-4-yl (499140-77-1); 1H-pyrazolo[3,4-d]pyrimidine-4-yl (496971-16-5); 1H-purine-6-yl (477280-92-5); 1H-pyrrolo[2,3-d]pyrimidine-4-yl (417721-57-4); purine-6-yl (409304-31-0, 397885-88-0); imidazo[1,2-c]pyrimidine-5-yl (371169-97-0); benzofuro[3,2-d]pyrimidine-4-yl (354130-21-5); 2,1,3-benzothiadiazole-7-yl (352347-99-0); naphthas[2,1-d]-1,3-axetil-2-oxo-4-yl (348579-51-1); thiazolo-[4,5-d]pyrimidine-7-yl (309735-15-7); 1H-pyrrolo[3,4-c]pyridine-4-yl (309735-15-7); 1,2,4-triazolo[4,3-a]cinoxacin-4-yl (223926-34-9); 1,2,4-triazolo[1,5-a]pyridin-5-yl (179098-91-0); pyrazolo[1,5-a]pyrimidine-7-yl (174668-50-9); 1,2,4-triazolo[1,5-a]pyrimidine-7-yl (174668-48-5); pyrido[1,2-a]benzimidazole-1-yl (612523-67-8); 1-indolizine-8-yl (622836-49-1); 1H-indol-4-yl (477856-99-8); benzo[b]thiophene-7-yl (475480-73-0); benzofuran-4-yl (475480-56-9); thieno[3,2-b]pyridin-7-yl (385783-90-4) imidazo[5,1-a]isoquinoline-5-yl (376356-45-6); pyrido[3,2-e]-1,2,4-triazolo[4,3-a]pyrazin-6-yl (308104-62-3); N-carbazole-5-yl (220862-74-8); 2,3,4,9-tetrahydro-1H-carbazole-5-yl (207340-78-1); isoxazole[5,4-d]pyrimidine-4-yl (141564-88-7); 1H-pyrazolo[3,4-d]pyrimidine-4-yl (393822-77-0).

The term "alkyl" refers to saturated linear or branched carbon chain. Preferably, the chain comprises from 1 to 8 carbon atoms.

The term "cycloalkyl" refers to a saturated monocyclic or bicyclic residue. Preferably, monocyclic system consists of 3-8 carbon atoms, and bicyclic system consists of 9-10 carbon atoms. Particularly preferred is a monocycle with the number of carbon atoms from three to six. Examples are cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.

The term "aryl" preferably refers to an aromatic monocyclic residue containing 6 carbon atoms, an aromatic bicyclic system containing 10 carbon atoms, or an aromatic tricyclic system containing 14 carbon atoms. Examples are phenyl, naphthalenyl or anthracene.

The term "aralkyl" refers to an alkyl residue, which is substituted by aryl, where alkyl and aryl have the above significance. An example is the benzyl radical.

The terms "alkenyl" and "cycloalkenyl" refer to olefinic unsaturated containing carbon atoms and C is pam or cycles with one or more double bonds. Examples are propanil and cyclohexenyl.

The term "quinil" refers to unsaturated containing atoms of carbon chains or cycles with one or more triple bonds. An example is propargyl.

According to one embodiment of the carbon atoms or the hydrogen atoms in alkyl, cycloalkyl, aryl, kalkilya, alkenyl, cycloalkenyl, etkinlik the radicals can be substituted, independently of one another, one or more elements selected from the group consisting of O, S, N, or groups containing one or more elements selected from the group consisting of O, S, N.

Embodiments include alkoxy, cycloalkane, aryloxy, Alcoxy, alkenylacyl, cycloalkenyl, alkyloxy, alkylthio, cycloalkyl, aaltio, Uralkali, alkanity, cycloalkenyl, alkylthio, alkylamino, cyclooctylamine, arylamino, aralkylamines, alkenylamine, cyclooctylamine, alkylamidoamines.

Other embodiments include hydroxyalkyl, hydroxycyclohexyl, hydroxyaryl, hydroxyalkyl, hydroxyalkyl, hydroxycyclohexanone, hydroxyalkenals, mercaptopurine, mercaptopurine, mercaptopurine, mercaptopurine, mercaptoquinoline, mercaptocysteine, mercaptoquinoline, aminoalkyl, aminocyclohexane, aminoaniline, Amina is alkyl, aminoacridine, aminocyclohexanone, aminoalkyl radicals.

According to one embodiment, where one or more carbon atoms, carbocyclic system replaced/substituted by one or more heteroatoms, forms a heterocyclic radical. The term "heterocyclyl" preferably refers to a saturated or partially unsaturated five-membered cycle, at least one member of which is an atom of N, O or S and which optionally contains one additional atom On one or additional N atom; a saturated or partially unsaturated six-membered cycle, at least one member of which is an atom of N, O or S and which optionally contains one additional atom On one or additional N atom, or two additional N atom; or a saturated or partially unsaturated deletechannel or deletechannel bicyclic residue, at least one member of which is an atom is N, O or S and which optionally contains one, two or three additional atom N. Heterocyclic group optionally substituted. Examples include, but are not limited to, pyrrolyl, pyrrolidinyl, imidazolyl, imidazolidinyl, pyrazolyl, pyrazolidine, piperidine, morpholine or piperazinil.

According to another embodiment of the hydrogen atoms in alkyl, cycloalkyl is s, aryl, kalkilya, alkenyl, cycloalkenyl, etkinlik the radicals can be substituted, independently of one another, by one or more halogen atoms. One radical is triptoreline radical.

If two or more radicals may be chosen independently from each other, then the term "independently" means that the radicals may be the same or may be different.

Aspects include compounds of General formula (V), where the remainder of AB may be substituted by one or more radicals selected from R3and R5and R3and R5independently selected from (C0-8)alkylene-R6where R6selected from the group consisting of hydrogen, (C1-8)alkoxyl, -, (halogen)1-3, -NR1R2, -NH-((C1-8)alkyl-R4), -NH-(aryl-R4), -NH-(heteroaryl-R4), -NH-(heterocyclyl-R4), -NH- ((C3-6)cycloalkyl-R4), -S-((C1-8)alkyl-R4), -S-(aryl-R4), -S-(heteroaryl-R4), -S-(heterocyclyl-R4), -S-((C3-6)cycloalkyl-R4), (C1-8)alkyl-R4, (C3-6)cycloalkyl-R4, heterocyclyl-R4, phenyl-R4, aryl-R4heteroaryl-R4and R4represents 1-3 substituent, independently selected from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, the Rila, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from the group consisting of H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2together form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Other aspects in accordance with this invention include compounds of formula (V), where het substituents in the residue het-(CH2)n-X is chosen, independently of one another from the group consisting of hydrogen, -F, -Cl, -OH, -CN, -NO2, -CF3, (C1-8)alkyl, (C3-6)cycloalkyl, heterocyclyl, phenyl, aryl, heteroaryl, (C1-8)alkoxyl, -O-phenyl, -O-aryl, -O-heteroaryl, -NR1R2, -CONR1R2, -S-(C1-5)alkyl, -S(O)2-(C1-5)alkyl, -S(O)2-NR1R2, -O-CO-(C1-5)alkyl, -O-CO-aryl, -CO-O-(C1-5)alkyl, -CO-O-aryl; and R1and R2independently selected from the group consisting of H, (C1-8)alkyl, (C3-6)cycloalkyl, phenyl, aryl or where R1and R2instead of the e form a saturated, partially unsaturated or unsaturated carbon chain, which contains from 3 to 7 carbon atoms, where at least one carbon atom may be replaced by O, S or N.

Further aspects in accordance with this invention include compounds of General formula (V), where n is 0 and X is O, S or NR7.

Further aspects of this invention include compounds of General formula (V), where n is 1 and X is O, S or NR7.

Preferred embodiments according to this invention include compounds of General formula (I), where n means 0 or 1 and X is S.

Other preferred embodiments according to this invention include compounds of General formula (I), where n is 1 and X is O or NR7.

In addition, one or more crystalline forms of the compounds of General formula (V) may exist as polymorphs. Assume that such forms are within the scope of the present invention. In addition, some of the compounds may form a solvate with water (i.e. hydrates) or common organic solvents, and imply that such a solvate is also included in the scope of the present invention.

Some of the compounds of General formula (V) are already known.

Another object of this invention is the use of compounds of General formula (V):

het-(CH2)n-X-AB(V)

where

het means a five-membered or six-membered N-heteroaryl or condensed five-membered or six-membered N-heteroaryl;

n means an integer and represents 0 or 1;

X is O, S, NR7and R7selected from R3;

and where the N-atom of the N-heteroaryl residue and the group -(CH2)n-X are separated by one carbon atom;

R3means hydrogen; alkyl; cycloalkyl; aryl; aralkyl; alkenyl; cycloalkenyl; quinil; and alkyl, cycloalkyl, aryl, aralkyl, alkenyl, cycloalkenyl, quinil can contain one or more elements selected from the group consisting of O, S, N, halogen (F, Cl, Br, I);

A represents aryl or heteroaryl;

In the mean residue containing five-membered cycle, and the above cycle is condensed with A;

or its pharmaceutically acceptable salt or MES or MES of such salt to obtain a pharmaceutical drug that inhibits NAD(P)H oxidase (NOX) and activation of platelets or NAD(P)H oxidase (NOX) or platelet activation.

Preferably, AB represents a 1,2,3-triazolo[4,5-d]pyrimidine-7-ilen radical of General formula (II):

where

R3means hydrogen; alkyl; cycloalkyl; aryl; aralkyl; alkenyl; cycloalkenyl quinil; moreover alkyl, cycloalkyl, aryl, aralkyl, alkenyl, cycloalkenyl, quinil can contain one or more elements selected from the group consisting of O, S, N, halogen (F, Cl, Br, I); and

R5means hydrogen; halogen (F, Cl, Br, I); HE; R3-S; NR1R2where R1and R2independently from each other mean R3or where R1and R2together form a cyclic system; het-(CH2)n-X.

The terms used in the examples describing the invention, are commonly used and well-known specialist in this field.

Examples

A. preparation of derivatives of 7-heteroaromatic-1,2,3-triazolo[4,5-d]pyrimidine and derivatives 7-heteroaromatic(5-substituted)-1,2,3-triazolo[4,5-d]pyrimidine

1. Getting the parent substance of General formula (III)

2-Mercaptothiazole

A mixture of 2-bromothiazole (4.6 g, 28 mmol) and thiourea (6.4 g, 84 mmol) in 250 ml of methanol is heated at the boil under reflux for 2 hours. The solution is evaporated and the residue is stirred with 0,5N NaOH solution for 15 minutes. The solution is then acidified (pH 4 using acetic acid, and extracted with ethyl acetate. The combined organic layers washed with water and saturated saline solution, dried (Na2SO4) and evaporated. After evaporation of the solvent the product (0.6 g, yield 18%) precipitated from ethyl acetate and n is Talanova ether.

1H-NMR (DMSO-d6) δ: 13,2 (s, 1H, SH); and 7.3 (d, 1H,N=); 7,0 (d, 1H,N=);

MS (+APCI)[mass spectrometry with chemical ionization at atmospheric pressure]: m/z = 118 (M+N)+.

2-Mercaptohexanol

To a suspension of potassium thiocyanate (5.8 g, 60 mmol) in acetonitrile (150 ml) with stirring, added dropwise concentrated hydrochloric acid (6.2 g). After stirring the suspension at room temperature for 1 hour and precipitated precipitated crystals are removed by filtration. To the resulting solution isocyanates acid in acetonitrile add dimer of glycolaldehyde (2.4 g, 20 mmol) and refluxed for 4 hours. After cooling, the solvent is evaporated and the residue purified by chromatography (ethyl acetate/petroleum ether = 3:2)to give the product as a solid beige color (3.2 g, yield 98%).

1H-NMR (DMSO-d6) δ: 13,0 (s, 1H, SH); 7.7 (d, 1H,N=); and 7.3 (d, 1H,N=);

MS (+APCI): m/z = 102 (M+N)+.

2. Obtaining a starting material for the synthesis of compounds

General formula (IV)

Benzylated

A mixture of sodium azide (7.6 g, 116,9 mmol), benzylbromide (10 g, for 58.4 mmol) in dimethyl sulfoxide (80 ml) was stirred at room temperature for 18 hours. The reaction mixture was then slowly poured into ice water and extracted with diethyl ether (3 x 200 ml) the combined organic extracts washed with water and saturated salt solution, dried (Na2SO4) and evaporated, getting mentioned in the title compound as a colourless oil (6.9 g, yield 88%).

1H-NMR (DMSO-d6) δ: 4.25 in (s, 2H, CH2); to 7.2 to 7.4 (m, 5H, phenyl).

MS (+EI)[mass spectrometry with ionization by electron impact]: m/z = 133 [M]+.

4-Amino-3-benzyl-5-aminotetrazole

Cyanoacetamide (4,34 g, 51.6 mmol) and benserazide (6,87 g, 51.6 mmol) are successively added to a solution of ateleta sodium (3.51 g, 51.6 mmol) in ethanol (50 ml). The reaction mixture is refluxed for 4 hours. The solid is filtered off and washed with water, dried in a desiccator over P2About5getting listed in the title compound as a white solid (7.8 g, yield 70%).

1H-NMR (DMSO-d6) δ: 4,35 (USS, 2H, NH2); to 5.35 (s, 2H, CH2); to 7.2 to 7.4 (m, 5H, phenyl); and 7.5 (s, 2H, CONH2).

MS (+APCI): m/z = 218 [M+H]+.

General method for the preparation of 3-benzyl-7-hydroxy-

1,2,3-triazolo[4,5-d]pyrimidines

4-Amino-3-benzyl-5-aminotetrazole (0.5 g, 2.3 mmol) and ethyl formate (ethyl acetate to 5-methyl or ethylbenzoic 5-phenyl) (9.2 mmol) are added to a solution of ateleta sodium (0,78 g, 11.5 mmol) in ethanol (50 ml). The mixture is refluxed for 24 hours, the solvent is evaporated and water is added. The resulting solid white color filter and p is washed with water, getting listed in the title compound (0,38 g, yield 73%).

3-Benzyl-7-hydroxy-1,2,3-triazolo[4,5-d]pyrimidine

1H-NMR (DMSO-d6) δ: of 5.55 (s, 2H, CH2); 7,2-7,3 (m, 5H, phenyl), and 7.9 (s, 1H, H-5); to 12.8 (s, 1H, HE).

MS (+APCI): m/z = 228 [M+H]+.

3-Benzyl-7-hydroxy-5-methyl-1,2,3-triazolo[4,5-d]pyrimidine

1H-NMR (DMSO-d6) δ: 2,4 (s, 3H, methyl); or 5.7 (s, 2H, CH2); 7.3 to 7.4 (m, 5H, phenyl).

MS (+APCI): m/z = 242 [M+H]+.

3-Benzyl-7-hydroxy-5-phenyl-1,2,3-triazolo[4,5-d]pyrimidine

1H-NMR (DMSO-d6) δ: 5,6 (s, 2H, CH2); 7,2-7,3 and 7.8 to 7.9 (m, 10H, phenyl).

MS (+APCI): m/z = 304 [M+H]+.

3. General method for the preparation of 3-benzyl-7-chloro-

1,2,3-triazolo[4,5-d]pyrimidines of formula (IV)

To a suspension of the corresponding 3-benzyl-7-hydroxytriazolam (5-H, methyl or phenyl) (10,56 mmol) in chloroform (50 ml) was added dimethylformamide (2 ml) and thionyl chloride (9 ml) and the mixture refluxed for 3 hours. The solvent is evaporated, keeping the temperature below 35aboutC. the Crude substance is subjected to chromatography using silica gel, elwira mixtures of petroleum ether with ethyl acetate. The resulting solid white color matches the title compound (1,14 g, 44%).

3-Benzyl-7-chloro-1,2,3-triazolo[4,5-d]pyrimidine

(source connection 1)

1H-NMR (DMSO-d6/sub> ) δ: 6,00 (s, 2H, CH2); 7.3 to 7.4 (m, 5H, phenyl); and 9.1 (s, 1H, H-5).

MS (+APCI): m/z = 246 [M+H]+.

3-Benzyl-7-chloro-5-methyl-1,2,3-triazolo[4,5-d]pyrimidine

(reference compound 2)

1H-NMR (DMSO-d6) δ: 2,8 (s, 3H, methyl); at 5.9 (s, 2H, CH2); 7.3 to 7.4 (m, 5H, phenyl).

MS (+APCI): m/z = 260 [M+H]+.

3-Benzyl-7-chloro-5-phenyl-1,2,3-triazolo[4,5-d]pyrimidine

(the original connection 3)

1H-NMR (DMSO-d6) δ: 6,0 (s, 2H, CH2); 7.3 to 7.4 (m, 3H, phenyl); 7.5 (m, 2H, phenyl); and 7.6 (m, 3H, phenyl); and-8.5 (m, 2H, phenyl).

MS (+APCI): m/z = 322 [M+H]+.

4. A General method of obtaining derivatives of 7-heteroaromatic-1,2,3-triazolo[4,5-d]pyrimidine and derivatives 7-heteroaromatic-(5-substituted)-1,2,3-triazolo[4,5-d]pyrimidines of General formula (I)

A solution of 3-benzyl-7-chlorotriethylsilane (0.2 g, 1 EQ.) formula (IV) of the corresponding compounds of formula (III) (1 EQ.) triethylamine (1 EQ.) in ethanol (5 ml) was stirred at room temperature or by boiling under reflux for 5 hours. The mixture is diluted with dichloromethane, washed with saturated solution of NaHCO3and saturated saline solution, dried (Na2SO4) and evaporated. Purification of column chromatography causes specified in the header connections.

Example 1

The compound of formula (III): 2-mercaptobenzoxazole

The compound of formula (IV): the original connection 1

3 Gasoline is-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (yield 74%)

1H-NMR (DMSO-d6) δ: 5,85 (s, 2H, CH2), 7.3 to 7.4 (m, 5H, phenyl), a 7.5 and 7.6 (m, 2H, aryl), a 7.85 (d, 1H, aryl), to 7.95 (d, 1H, aryl), of 8.95 (s, 1H, H-5).

MS (+APCI): m/z = 361 [M+H]+.

Example 2

The compound of formula (III): 2-mercaptopyridine

The compound of formula (IV): the original connection 1

3-Benzyl-7-(2-pyridyl)thio-1,2,3-triazolo[4,5-d]pyrimidine

(yield 53%)

1H-NMR (DMSO-d6) δ: 5,90 (s, 2H, CH2), 7.3 to 7.4 (m, 5H, phenyl), 7,55 (m, 1H, pyridyl), and 8.0 (d, 2H, pyridyl), and 8.7 (d, 2H, pyridyl), 8,9 (s, 1H, H-5).

MS (+APCI): m/z = 321 [M+H]+.

Example 3

The compound of formula (III): 2-mercaptohexanol

The compound of formula (IV): the original connection 1

3-Benzyl-7-(2-oxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (yield 73%)

1H-NMR (DMSO-d6) δ: 5,90 (s, 2H, CH2), 7.3 to 7.4 (m, 5H, phenyl), and 7.6 (s, 1H, aryl), 8,55 (s, 1H, aryl), of 8.95 (s, 1H, H-5).

MS (+APCI): m/z = 311 [M+H]+.

Example 4

The compound of formula (III): 2-mercaptothiazole

The compound of formula (IV): the original connection 1

3-Benzyl-7-(2-thiazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine

(yield 83%)

1H-NMR (DMSO-d6) δ: 6,1 (s, 2H, CH2), of 7.4-7.5 (m, 5H, phenyl), and 8.2 (d, 1H, aryl), and 8.3 (d, 1H, aryl), to 9.15 (s, 1H, H-5).

MS (+APCI): m/z = 327 [M+H]+.

Example 5

The compound of formula (III): 2-mercaptoimidazole

The compound of formula (IV): the original connection 1

3-Benzyl-7-(2-imidazolyl)thio-1,2,3-Tr is azolo[4,5-d]pyrimidine (yield 74%)

1H-NMR (DMSO-d6) δ: 5,8 (s, 2H, CH2), and 7.1 (s, 1H, imide.), a 7.2 to 7.3 (m, 5H, phenyl), and 7.4 (s, 1H, imide.), of 8.8 (s, 1H, H-5).

MS (+APCI): m/z = 310 [M+H]+.

Example 6

The compound of formula (III): 2-mercaptobenzoxazole

The compound of formula (IV): the original connection 2

3-Benzyl-7-(2-benzoxazolyl)thio-5-methyl-1,2,3-triazolo[4,5-d]pyrimidine (yield 63%)

1H-NMR (DMSO-d6) δ: 2,7 (s, 3H, methyl), to 5.85 (s, 2H, CH2), 7.3 to 7.4 (m, 5H, phenyl), a 7.5 and 7.6 (m, 2H, aryl), a 7.85 (d, 1H, aryl), to 7.95 (d, 1H, aryl).

MS (+APCI): m/z = 375 [M+H]+.

Example 7

The compound of formula (III): 2-mercaptobenzoxazole

The compound of formula (IV): the original connection 3

3-Benzyl-7-(2-benzoxazolyl)thio-5-phenyl-1,2,3-triazolo[4,5-d]pyrimidine (yield 62%)

1H-NMR (DMSO-d6) δ: 5,9 (s, 2H, CH2), and 7.3 and 7.6 (m, 10H, aryl), and 7.9 (d, 1H, aryl), and 8.0 (d, 1H, aryl), 8,15 (d, 2H, aryl).

MS (+APCI): m/z = 437 [M+H]+.

In.Preparation of derivatives of 7-heteroaromatic-(N-3-substituted)triazolopyrimidine

1. Getting educt for the synthesis of 7-chloro-(N-3-substituted)-1,2,3-triazolo[4,5-d]pyrimidines of formula (IV)

4,6-Dichloro-5-nitropyrimidin

Dimethylaniline (32,6 ml, 246 mmol) are added to a suspension of 4,6-dihydroxy-5-nitropyrimidine (25 g, 160 mmol) in phosphorus oxychloride (96 ml, 1056 mmol) and heated on an oil bath at a temperature of 125-130aboutC for 1 hour. Excess oxychloride fo the handicap is removed by evaporation and the residue was poured onto ice (300 g). The formed solid is filtered off and the filtrate is extracted with diethyl ether. The combined organic layers washed with water and saturated saline solution, dried (Na2SO4) and evaporated. After evaporation of the solvent the residue is purified with flash chromatography using dichloromethane and the product is obtained in the form of a solid pale brown (21,5 g, yield 70%).

1H-NMR (DMSO-d6), δ: 8,3 (s, 1H, aryl).

General method of synthesis of 4-chloro-6-(substituted amino)-5-nitropyrimidine

The appropriate amine (0.8 to 0.9 EQ.) added in several portions to a stirred solution of 4,6-dichloro-5-nitropyrimidine (31 mmol, 1 EQ.) triethylamine (2 EQ.) in tetrahydrofuran (100 ml) at 0°C. the resulting solution was stirred for 2 hours at a temperature of from 0°C. to room. Then water is added and the reaction mixture is extracted with ethyl acetate.

The combined organic layers washed with water and saturated saline solution, dried (Na2SO4) and evaporated. After evaporation of the solvent the residue is purified by chromatography (petroleum ether/ethyl acetate)to give the desired product.

4-Chloro-6-methylamino-5-nitropyrimidin (yield 56%)

1H-NMR (DMSO-d6), δ: 8,4 (s, 1H, aryl); 8.3 (USS, 1H, NH); 2,9 (d, 3H, CH3).

MS (+APCI): m/z = 189 (M+N)+.

4-Chloro-5-nitro-6-f is relaminarization (yield 52%)

1H-NMR (DMSO-d6), δ: a 10.1 (s, 1H, NH); and 8.4 (s, 1H, aryl); 7.5 (d, 2H, aryl); and 7.4 (t, 2H, aryl); to 7.2 (m, 1H, aryl).

MS (+APCI): m/z = 251 (M+N)+.

4-Chloro-6-p-methoxybenzylamine-5-nitropyrimidin

(yield 72%)

1H-NMR (DMSO-d6), δ: 9,0 (Ust, 1H, NH); and 8.4 (s, 1H, aryl); to 7.2 (d, 2H, aryl); and 6.9 (d, 2H, aryl); and 4.6 (d, 2H, CH2); 3,7 (s, 3H, CH3).

MS (+APCI): m/z = 295 (M+N)+.

4-Chloro-6-about-chlorobenzylamino-5-nitropyrimidin (yield 67%)

1H-NMR (DMSO-d6), δ: 9,0 (Ust, 1H, NH); and 8.4 (s, 1H, aryl); 7.5 (m, 1H, aryl); to 7.2 (m, 3H, aryl); 4,7 (d, 2H, CH2).

MS (+APCI): m/z = 299 (M+N)+.

General method of synthesis of 4-chloro-6-(substituted amino)-5-aminopyrimidine

Iron powder (10 EQ.) add to intensively mix the solution of the corresponding 4-(substituted amino)-6-chloro-5-nitropyrimidine (14 mmol, 1 EQ.) in acetic acid (300 ml), used as a solvent. The mixture is stirred at room temperature for 3 hours and concentrated in vacuo. The residue is diluted with ethyl acetate and the mixture washed with a solution of NaHCO3to neutral pH values.

The combined organic layers washed with water and saturated saline solution, dried (Na2SO4) and evaporated, getting listed at the beginning of the connection.

5-Amino-4-chloro-6-methylaminopropane (yield 65%)

1H-NMR (d 6), δ: 7,7 (s, 1H, aryl); 6,8 (USS, 1H, NH)and 4.9 (s, 2H, NH2); 2,9 (d, 3H, CH3).

MS (+APCI): m/z = 159 (M+N)+.

5-Amino-4-chloro-6-phenylaminopyrimidine (yield 91%)

1H-NMR (DMSO-d6): δ 8,6 (s, 1H, NH); 7,8 (s, 1H, aryl); and 7.8 (d, 2H, aryl); to 7.2 (t, 2H, aryl); 7,0 (m, 2H, aryl); to 5.4 (s, 2H, NH2).

MS (+APCI): m/z = 221 (M+N)+.

5-Amino-4-chloro-6-p-methoxybenzylideneamino (yield 98%)

1H-NMR (DMSO-d6): δ 7,8 (s, 1H, NH); to 7.2 (m, 3H, aryl); and 6.9 (d, 2H, aryl); to 5.1 (s, 2H, NH2); and 4.5 (d, 2H, CH2); 3,7 (s, 3H, CH3).

MS (+APCI): m/z = 265 (M+N)+.

5-Amino-4-chloro-6-about-chlorobenzenesulfonamide (yield 67%)

1H-NMR (DMSO-d6): δ of 7.7 (s, 1H, aryl); 7,4 (USS, 1H, NH); to 7.2 (m, 4H, aryl); 5,1 (USS, 2H, NH2); and 4.6 (d, 2H, CH2).

MS (+APCI): m/z = 269 (M+N)+.

General methods of synthesis of 7-chloro-3-substituted-1,2,3-triazolo[4,5-d]pyrimidine as starting compounds of the formula (IV) to obtain 7-heteroaromatic-(N-3-substituted)-1,2,3-triazolo[4,5-d]pyrimidines of General formula (I)

A solution of sodium nitrite (1.2 EQ.) in water (30 ml) is added dropwise to a cooled (0-5aboutC) mixed solution of the appropriate 5-amino-4-chloro-6-amino-pyrimidine (14 mmol, 1 EQ.) in acetic acid (25 ml) and water (90 ml). The mixture is stirred for 2 hours at a temperature of from 0°C. to room. Then add ethyl acetate and the mixture washed with POM is using a solution of NaHCO 3to neutral pH values. The combined organic layers washed with water and saturated saline solution, dried (Na2SO4) and evaporated, getting listed at the beginning of the connection.

7-Chloro-3-methyl-1,2,3-triazolo[4,5-d]pyrimidine (yield 86%; source connection 4)

1H-NMR (DMSO-d6), δ: 9,1 (s, 1H, aryl); and 4.4 (d, 3H, CH3).

MS (+APCI): m/z = 170 (M+N)+.

7-Chloro-3-phenyl-1,2,3-triazolo[4,5-d]pyrimidine (yield 96%; source connection 5)

1H-NMR (DMSO-d6), δ: 9,2 (s, 1H, aryl); and 8.1 (m, 2H, aryl), and 7.7 (m, 2H, aryl); 7,6 (m, 1H, aryl).

MS (+APCI): m/z = 232 (M+N)+.

7-Chloro-3-p-methoxybenzyl-1,2,3-triazolo[4,5-d]pyrimidine

(yield 82%; the original connection 6)

1H-NMR (DMSO-d6), δ: 9,2 (s, 1H, aryl); and 7.4 (d, 2H, aryl); and 6.9 (d, 2H, aryl); and 5.8 (s, 2H, CH2); 3,7 (s, 3H, CH3).

MS (+APCI): m/z = 276 (M+N)+.

7-Chloro-3-aboutchlorbenzyl-1,2,3-triazolo[4,5-d]pyrimidine

(yield 96%; original connection 7)

1H-NMR (DMSO-d6), δ: 9,1 (s, 1H, aryl); 7.5 (m, 1H, aryl); and 7.3 (m, 3H, aryl); or 6.2 (s, 2H, CH2).

MS (+APCI): m/z = 280 (M+N)+.

2. General methods of synthesis of derivatives of 7-heteroaromatic-(N-3-substituted)-1,2,3-triazolo[4,5-d]pyrimidine of the General formula (I)

2-Mercaptobenzoxazole (1 EQ.) at room temperature are added to a solution of the corresponding 7-chloro-3-substituted-1,2,3-triazolo[4,5-d]pyrim the Dina (2 mmol, 1 EQ.) triethylamine (1.2 EQ.) in ethanol (25 ml). The solution is stirred for 4 hours. The precipitate is filtered off and the filtrate is purified by chromatography.

Example 8

The original compound of formula (III): 2-mercaptobenzoxazole

The original compound of formula (IV): the original connection 4

7-(2-Benzoxazolyl)thio-3-methyl-1,2,3-triazolo[4,5-d]pyrimidine (yield 51%; by deposition)

1H-NMR (DMSO-d6): δ 9,0 (s, 1H, aryl); and 7.9 (m, 1H, aryl); 7,8 (m, 1H, aryl); to 7.4 (m, 2H, aryl); 4,3 (s, 3H, CH3).

MS (+APCI): m/z = 284 (M+N)+.

Example 9

The original compound of formula (III): 2-mercaptobenzoxazole

The original compound of formula (IV): the original connection 5

7-(2-Benzoxazolyl)thio-3-phenyl-1,2,3-triazolo[4,5-d]pyrimidine (yield 69%; by deposition)

1H-NMR (DMSO-d6): δ 9,0 (s, 1H, aryl); or 8.2 (m, 2H, aryl); and 7.9 (m, 1H, aryl); 7,8 (m, 1H, aryl); 7,6 (m, 2H, aryl); 7.5 (m, 3H, aryl).

MS (+APCI): m/z = 347 (M+N)+.

Example 10

The original compound of formula (III): 2-mercaptobenzoxazole

The original compound of formula (IV): the original connection 6

7-(2-Benzoxazolyl)thio-3-p-methoxybenzyl-1,2,3-triazolo[4,5-d]pyrimidine (yield 70%; by deposition)

1H-NMR (DMSO-d6): δ 9,0 (s, 1H, aryl); and 7.9 (d, 1H, aryl); 7,8 (d, 1H, aryl); 7.5 (m, 2H, aryl); and 7.3 (d, 2H, aryl); and 6.9 (d, 2H, aryl); and 5.8 (s, 2H, CH2); 3,7 (s, 3H, OCH3).

MS (+APCI): m/z = 391 (M+N)+.

P the emer 11

The original compound of formula (III): 2-mercaptobenzoxazole

The original compound of formula (IV): the original connection 7

7-(2-Benzoxazolyl)thio-3-aboutchlorbenzyl-1,2,3-triazolo[4,5-d]pyrimidine (yield 75%; by deposition)

1H-NMR (DMSO-d6): δ 8,9 (s, 1H, aryl); 7,8 (d, 1H, aryl); 7.7 (d, 1H, aryl); 7.5 (m, 3H, aryl); and 7.3 (m, 3H, aryl); 6,0 (s, 2H, CH2).

MS (+APCI): m/z = 395 (M+N)+.

Particularly preferred compounds according to the invention include

(2-imidazolyl)thio
Table 1
Examplehet-(CH2)n-X R3R5R3R5
1(2-benzoxazolyl)thioBenzilN
2(2-pyridyl)thioBenzilN
3(2-oxazolyl)thioBenzilN
4(2-thiazolyl)thioBenzilN
5BenzilN
6(2-benzoxazolyl)thioBenzilMethyl
7(2-benzoxazolyl)thioBenzilPhenyl
8(2-benzoxazolyl)thioMethylN
9(2-benzoxazolyl)thioPhenylN
10(2-benzoxazolyl)thio3-p-methoxybenzylN
11(2-benzoxazolyl)thio3-o-chlorbenzylN

C. Inhibition of NAD(P)H-oxidase

Determination of the reduction of cytochrome C was used to evaluate the activity of NOX in the cells HL-60.

Cell culture

Human cell line acute myeloid leukemia HL-60 (ESAS 98070106) were cultured in medium RPMI 1640 (Biochrom, Berlin, Germany), supplemented with 5% inactivated palamarev calf serum, 2 mm glutamine (GLUTAMAX, Invitrogen, Karlsruhe, Germany), 100 U/ml penicillin (Sigma, Taufkirchen, Germany) and 100 μg/ml streptomycin (Sigma, Taufkirchen, Germany), at 37°C in a humidified atmosphere with 5% CO2. Cells were maintained in an amount of 0.1 to 2.0×106cells/ml To induce myeloid differentiation produced seeding cells at a density of 0.5×106cells/ml and were cultured for 6 days in medium containing 1,25% (vol./about.) dimethyl sulfoxide (DMSO).

Analysis activity NOX

Differentiated cells HL-60 resuspendable and then washed with 1 volume of balanced salt Hanks solution (HBSS) without phenol red (Invitrogen, Karlsruhe, Germany). 40×106cells were then washed with 4 ml of HBSS containing 100 μm cytochrome C (from horse heart, Sigma, Taufkirchen, Germany). After centrifugation (10 minutes at 300 acceleration (g) debris resuspendable in 9 ml of HBSS containing 111 µm cytochrome C (final concentration in the analysis after adding other solutions: about 100 μm). The same solution HBSS/cytochrome C was used as control.

1 μl/well of a solution of each compound being tested for its ability to inhibit NOX, pietravalle in 96-well plates (Greiner, Frickenhausen, Germany). At least two rows (i.e. 16 holes) 96-hole of the tablet on the left were not filled. If the soedineniya was dissolved in DMSO, in blank wells were added 1 μl of DMSO. The compounds were added to 90 ál/well of cell suspension in HBSS solution/cytochrome C. To control 12 unfilled holes pietravalle 90 µl/well of cells. For single experience 90 μl of a solution of HBSS/cytochrome C without cells) was added in 4 blank wells. 4 control wells were added to 1 μl of 1 mm diphenylacetonitrile* (DPI, final concentration 10 μm; Alexis, Lausen, Switzerland). DPI was used as a control inhibitor.

E550and E540measured once before stimulation of the cells in a microplate reader (Multiskan Spektrum, Thermo Electron Corporation, Dreieich, Germany). E540means isosbestic point and used to normalize the absorbance at 550 nm (E550/E540). For stimulation to the cells was added 10 μl of 1 μm phorbol 12-myristate-13-acetate** (PMA, final concentration 100 nm; Alexis, Lausen, Switzerland). 4 wells containing control cells, missed. In these 4 holes as holes for idle experience, was added 10 μl of HBSS.

The tablet was dissolved in 10 seconds on a microplate reader, and then incubated at temperature 37aboutC in humidified atmosphere with 5% CO2. E550and E540was measured after 60 and 120 minutes.

To calculate the absorbance at 550 nm was normalized to the absorption in isosbestic point at 540 nm for each individual wells. Average of che is ireh blank values subtracted from each fixed value for each point in time. The NOX activity was expressed in % activity stimulated with PMA control cells. The residual activity processed by the DPI cells was usually <10%.

In some experiments as a control was used at 100 U/ml superoxide dismutase (SOD; from bovine erythrocytes; ES.; Alexis, Lausen, Switzerland). The inhibition signal using SOD was >95%.

* DPI solution: 10 mm initial solution in DMSO was diluted in the ratio 1:10 with HBSS. This solution was used for analysis.

**The solution of RMA: 10 mm initial solution in DMSO was diluted first in a ratio of 1:10 with DMSO and then in the ratio of 1:100 using HBSS. This solution was diluted further, in the ratio of 1:10 with HBSS and used for analysis.

Table 2
Values IR50(inhibiting 50% concentration) of compounds listed in table 1
ExampleIR50[µm]
12
213
32
42
5 12
61
82
91
102
112

D. Inhibition of thrombin-induced platelet activation

The expression of P-selectin on the surface of platelets was used as a marker of platelet activation.

All experiments were carried out using washed platelets (PRP). Fresh venous blood from healthy volunteers (40 ml) was collected in 10 ml of 5×CCD-solution (7 mm citric acid, 100 mm triacrylate, 140 mm glucose, 15 mm ethylenebis(oxyethylenenitrilo)tetraoxane acid (EGTA) as anticoagulant, pH 6.5). Platelet-rich plasma was obtained by centrifugation at acceleration 300 g for 20 minutes. The supernatant was collected and incubated for 10 minutes at room temperature. Platelets besieged from the supernatant by the second stage centrifuge acceleration of 500 g for 20 minutes. Sediment resuspendable in 5 ml of HEPES-buffer (145 mm Nad, 5 mm KCl, 1 mm MgCl2, 10 mm glucose, 10 mm HEPES, pH 7.4). The concentration of platelets was brought to 3×108platelets/ml with HPES-buffer.

Washed platelets (0.2 ml) was kept for 1 hour at room temperature in a siliconized reaction tubes. After pre-incubation with the compounds of examples 1-11 for 1 minute, washed platelets were stimulated for 2 minutes with the help of activating the thrombin receptor peptide (TRAP-6, BACHEM Biochemicals, Heidelberg, Germany).

As a positive control, 0.2 ml of washed platelets were subjected to pre-incubation with releasing NO connection, sodium nitroprusside (SNP, Sigma, Deisenhofen).

After incubation, 20 μl of the sample was pietravalle in 10 ál of labeled fluoresceinisothiocyanate (FITC) antibodies against CD62P (DAKO, Glostrup, Denmark) and incubated for 15 minutes in the dark. After incubation, the samples were diluted with 1.5 ml phosphate buffered saline and immediately measured in the cytometer.

To subtract the background one sample was incubated with 10 ál of labeled using FITC nonspecific murine IgGI (DAKO, Glostrup, Denmark).

For cytometry used cell sorters with excitation fluorescence (FACS) Calibur company Becton-Dickinson (position: FSC: E00; SSC: 337; FL-1: 600). For each dimension were analyzed 20000 cells. The results were obtained as the average fluorescence intensity (MFI), calculated using the software CellQuest (version 1.0; Becton - Dickinson).

Inhibition of activation is robotito represented in the form of a reduction in the percentage of induced TRAP-6 expression of P-selectin in the presence of 5 μmol/l of the compounds of examples 1-11:

Table 3
Inhibition of platelet activation
Example% inhibition of activation
149
234
355
445
521
639
838
944
1060
1180

1. The compound of General formula (I):
,
where het means a five-membered N-heteroaryl, additionally comprising one atom O, S or N as heteroatoms, and heteroaryl, including additional atom On can be condensed with a benzene ring or six-membered N-heteroaryl;
X is S;
and where the N-atom of the N-heteroaryl residue, and group X are separated by one atom of plastics technology : turning & is Yes;
AB means 1,2,3-triazolo[4,5-d]pyrimidine-7-ilen radical of General formula (II):

where R3means1-8alkyl; phenyl; benzyl, optionally substituted with halogen or1-8-alkoxy group; and
R5means hydrogen; C1-8alkyl; phenyl.

2. The compound according to claim 1, where the five-membered N-heteroaryl selected from the group consisting of imidazolyl, oxazolyl, isoxazolyl, thiazolyl.

3. The compound according to claim 1, where the six-membered N-heteroaryl selected from the group consisting of pyridinyl.

4. The compound according to claim 1, where the compound is 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine.

5. The method of obtaining compounds of General formula (I) according to any one of claims 1 to 4, where the compound of General formula (III) enter into interaction with the compound of General formula (IV):


where het-X and AB have specified in claim 1 value, N denotes a hydrogen atom and Y represents a leaving group.

6. The use of the compounds of formula (I) according to claim 1 for obtaining a pharmaceutical composition inhibiting NAD(P)H oxidase (NOX) or induced by thrombin activation of platelets.

7. The use according to claim 6, where the pharmaceutical composition is intended for the treatment of diseases and disorders selected from cardiovascular disorders, cancer, autoimmune diseases, stroke, neurodegenerative diseases, cystic degeneration, or used in antithrombotic therapy.

8. The use according to claim 7, where cardiovascular disease and impaired selected from the group consisting of hypertension, atherosclerosis, hypercardia, heart failure, restenosis, diabetes, and angina.

9. The use according to claim 7, where the neurodegenerative disease is Alzheimer's disease or Parkinson's disease.



 

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SUBSTANCE: invention relates to novel 5,7-diamino-substituted pyrazolo[1,5-a]pyrimidines selected from specific compounds, e.g. those given below, which have cyclin-dependent kinase inhibiting properties, such as CDK2. The compounds can be used to treat diseases and conditions associated with CDK, such as proliferative diseases, leukaemia.

.

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: R1 is selected from a group comprising: (a) saturated cyclic radical containing 3-8 ring atoms, from which 1-3 atoms are N atoms, which can contain up to four substitutes independently selected from a group comprising: (i) lower alkyl; and (ii) CO2R3, OR7 or S(O)nR8; (b) C6-C10aryl, which can contain up to four substitutes independently selected from a group comprising: (i) S(O)nR8, lower alkyl; OR7 and halogen; (c) C3-C8cycloalkyl, which can be substituted with NR5R6; and (d) lower alkyl, which can be substituted: (i) OR7, NR5R6; R2 is selected from a group comprising: (i) H; (ii) lower alkyl; (iii) C6-C10aryl which can be substituted with a halogen, lower alkyl, lower alkoxy group; R3 is selected from a group comprising: (i) H; (ii) lower alkyl; (iv) C3-C8cycloalkyl; R5 and R6 are independently selected from a group comprising: (i) H; (ii) lower alkyl; (iii) C3-C8cycloalkyl; (v) SO2R3; and (vi) CO2R3; R7 is selected from a group comprising H and lower alkyl; R8 is selected from a group comprising: (iii) NR5R6; (iv) lower alkyl; and n equals 1 or 2.

EFFECT: capacity to inhibit activity of cyclin-dependant kinase.

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula [I-D1] or pharmaceutically acceptable salt thereof,

,

where each symbol is defined in the claim. The invention also relates to pharmaceutical compositions containing said compound and having HCV polymerase inhibiting activity.

EFFECT: disclosed compound exhibits anti-HCV activity, based on HCV polymerase inhibiting activity and is useful as an agent for preventing and treating hepatitis C.

32 cl, 497 tbl, 1129 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new compounds of formula I and to their pharmaceutically acceptable salts exhibiting inhibitory activity in relation to kinases chosen from Abl, Bcr-Abl, Bmx, BTK, b-RAF, c-RAF, CSK, cSRC, Fes, FGER3, Elt3, 1KKα, 1KKβ, JNK1α1, JNK2α2, Lck, Met, MKK4, MKK6, p70S6K, PAK2, PDGFRα, PKA, PKCα, PKD2, ROCK-II, Ros, Rsk1, SAPK2α, SAPK2β, SAPK3, SAPK4, SGK, Syk, Tie2 and TrkB. In compounds of formula I , n is equal to 1, m is equal to 0, Y1 is chosen from N and CR5, and R5 represents hydrogen, Y2 represents O, R1 represents hydrogen, R2 is chosen from hydrogen and C1-C6alkyl, R3 is chosen from a group including hydrogen, C1-C6alkyl, C1-C6alkoxy, R4 is chosen from NR5C(O)R6 and -C(O)NR5R6 where R5 is chosen from hydrogen and C1-C6 alkyl, and R6 represents phenyl optionally substituted with 1-3 radicals chosen of a group including NR3R3, halogen-substituted C1-C6alkyl, C5-C6heteroaryl(C0-C4)alkyl where heteroaryl contains 1-2 heteroatoms chosen from N and O, C5-C6heterocyclo(C0-C4)alkyl, where heterocyclyl contains 1-2 heteroatoms of N, and C5-C6heterocyclo(C0-C4)alkoxy where heterocyclyl contains 1-2 heteroatoms of N, and any heteroaryl or heterocyclyl contained in R6 is optionally substituted by 1-3 radicals independently chosen from a group including C1-C6alkyl and hydroxy(C1-C6)alkyl.

EFFECT: producing the compounds which can find application for treatment or prevention of diseases or disorders associated with abnormal or unregulated kinase activity, such as proliferative diseases, diseases of immune and nervous system.

8 cl, 26 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a novel chemical compound - 1-(2-isopropoxyethyl)-2-thioxo-1,2,3,5-tetrahydro-pyrrolo [3,2-d]pyrimidin-4-one and pharmaceutically acceptable salts thereof, a pharmaceutical composition containing said compounds and use thereof. Disclosed compound has myeloperoxidase enzyme inhibiting properties.

EFFECT: compounds are especially useful in treating and preventing neuroinflammatory disorders such as Parkinson's disease, cardiovascular disorders and respiratory disorders.

3 cl, 1 tbl, 33 ex

FIELD: chemistry.

SUBSTANCE: invention relates to novel derivatives of isothiazole-3(2H)-OH-1,1-dioxides of formula (I) or pharmaceutically acceptable salts thereof, which can increase expression of LXR α and/or β, a pharmaceutical composition based on said derivatives, use thereof in preparing a medicinal agent, as well as novel intermediate compounds of formula (V) or salts thereof. In formulae (I), (V) R2 denotes phenyl, and R1 and R3 are as described in the claim.

EFFECT: improved properties of the derivatives.

7 cl, 9 dwg, 172 ex

FIELD: medicine.

SUBSTANCE: claimed is application of known anticonvulsant lamotrigine (other names of substance - lamictal, lamolep) as medication, which prevents ischemic and hypoxic disorders in acute period of craniocerebral injury. Demonstrated is prevention of secondary disorders of brain functions as a result of ischemia, hypoxia with hypercapnia, hemic hypoxia with simultaneous facilitation of recovering neuro-physical status.

EFFECT: lamotrigine increases brain stability to major factors of its secondary injury by 24,9-42,6% and improves life duration of mice in post traumatic period by 109,6%.

5 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to a method for structural and/or functional improvement of arterioles in mammals with a pathology which is characterised by thickened walls of cerebral or renal arterioles involving introduction to said mammal of a peptide with an amino acid sequence D-W-F-K-A-F-Y-D-K-V-A-E-K-F-K-E-A-F (SEQ ID No. 5) or an inverted sequence F-A-E-K-F-K-E-A-V-K-D-Y-F-A-K-F-W-D (SEQ ID No. 444), in doses sufficient for structural and/or functional improvement of arterioles.

EFFECT: invention provides structural and/or functional improvement of arterioles and preserved functions of the essential target organs such as brain and kidneys.

20 cl, 2 ex, 29 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to compounds of formula I and to their pharmaceutically acceptable salts. In formula I p is integer, equal to 0-1; L2 is selected from group including -XOX-, -XSX- and -XSXO-; where X is independently selected from group, including bond and C1-C4alkylene; R13 is selected from group, including halogen, C1-C6alkyl, C1-C6alkoxygroup, -C(O) C1-C6alkyl; R14 is selected from group, including -XOXC(O)OR17 and -C1-C4alkylene-C(O)OR17; where X represents bond or C1-C4alkylene; and R17 is selected from group, including hydrogen and C1-C6alkyl; R15 and R16 are independently selected from group, including -R18 and -YR18; where Y represents C2-C6alkenylene, and R18 is selected from group, including C6-C10aryl, benzo[1,3]dioxolyl, pyridinyl, pyrimidinyl, quinolyl, phenoxatiinyl, benzofuranyl, dibenzofuranyl, benzoxasolyl, 2,3-dihydrobenzofuranyl, 2-oxo-2,3-dihydrobenzooxasolyl, indolyl, 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazinyl, 2,3-dihydrobenzo[1,4]dioxinyl, 3,4-dihydro-2H-benzo[b][1,4]dioxepinyl, where any C6-C10aryl, pyridinyl, benzoxasolyl, indolyl in R18 is optionally substituted by 1-2 radicals, independently selected from group, including halogen, nitrogroup, cyanogroup, C1-C6alkyl, C1-C6alkoxygroup, C1-C6alkylthiogroup, hydroxy-C1-C6alkyl, halogen-substituted C1-C6alkyl, halogen-substituted C1-C6alkoxygroup, piperidinyl, morpholinyl, pyrrolidinyl, phenyl, XS(O)0-2R17, -XNR17R17, -XNR17S(O)2R17, -XNR17C(O)R17, -XC(O)NR17R17, -XC(O)NR17R19, -XC(O)R17, -XC(O)R19 and -XOXR19, where X represents bond; R17 is selected from group, including hydrogen, C1-C6alkyl, halogen-substituted C1-C6alkyl, and R19 is selected from group, including C3-C12cycloalkyl, phenyl, piperidinyl, morpholinyl.

EFFECT: ensuring application of invention compounds for production of medication, modulating activity of activated receptors of peroxisome proliferators δ (ARPPδ), to pharmaceutical composition, possessing properties of ARPPδ activity modulator, including therapeutically efficient quantity of invention compound and to application of pharmaceutical composition for medication manufacturing.

8 cl, 1 tbl, 301 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to compound of formula I: where: R1 represents R6C(O)-, R6SO2-, (R6)2NC(O)-; R2 represents hydrogen, -CF3 or R8; R3 represents -T-R9; R4 represents -COOH or -COOR8; R5 represents -CH2F or -CH2O-2, 3, 5, 6 - tetrafluorophenyl; R6 represents R6a or R6b; two R6 groups, together with the atom to which they are bound optionally form 3-10-member aromatic or non-aromatic ring; and where each R6 is independently substituted with 6 substituents, independently selected from R; R6a and R6b each independently represents (C1-C3)-aliphatic group, (C6-C10)-aryl-, (C6-C10)-aryl-(C1-C12) aliphatic group; R represents halogen, -OR7, -R7; each R7 is independently selected from: hydrogen, (C1-C12)-aliphatic group, (C6-C10)-aryl; R8 represents (C1-C12)-aliphatic group; T represents direct bond or (C1-C6)-aliphatic group, where to 2 aliphatic carbon atoms in T can be optionally substituted with O; R9 is optionally substituted (C6-C10)-aryl or (C5-C10) - heteroaryl, invention also relates to pharmaceutical composition, to methods of treatment, inhibition of caspase-mediated processes, to method of cell preservation with application of formula I compounds application of such compositions for treatment of caspase-mediated diseases and to methods of obtaining formula I compounds.

EFFECT: obtained and described are novel compounds, which can be useful in treatment of caspase-mediated diseases.

38 cl, 22 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: offered is a new modified release dosage form of trimetazidine dihydrochloride in the form of an oral tablet which contains an active substance in amount 3.5 - 70.0 wt %, mixed povidone and polyvinyl acetate as a release modifier in amount 20.0 - 70.0 wt % and pharmaceutically acceptable pharmaceutical aids. Preferentially, the dosage form of trimetazidine dihydrochloride as mixed povidone and polyvinyl acetate contains Collidon SR.

EFFECT: invention shall allow to enlarge the range of high quality, available domestic modified release drugs.

18 cl, 2 tbl

FIELD: chemistry.

SUBSTANCE: disclosed compounds can be used as a medicinal agent which modulates PPARδ (peroxisome proliferator-activated receptor δ). In formula I

, p is equal to 1; L2 is selected from a group which includes -XOX- and -XSX-, where X is independently selected from a group which includes a bond and C1-C4alkylene; R13 is selected from a group which includes halogen, C1-C6alkyl; R14 is selected from a group which includes -XOXC(O)OR17 and -XC(O)OR17, where X denotes a bond or C1-C4alkylene and R17 denotes hydrogen; R15 and R16 are independently selected from a group which includes -R18 and -YR18, where Y is selected from a group which includes C2-C6alkenylene, and R18 is selected from a group which includes C6-C10aryl, pyridinyl, pyrimidinyl, quinolinyl, benzo[b]furanyl, benzoxazolyl, 1,5-benzodioxanyl, 1,4-benzodioxanyl and 3,4-dihydro-2H-benzo[b][1,4]dioxepin; where any of phenyl, pyridinyl, pyrimidinyl, benzoxazolyl in R18 is independently substituted with 1-2 radicals, independently selected from a group which includes halogen, C1-C6alkyl, C2-C7alkenyl, C1-C6alkoxy group, halogen-substituted C1-C6alkyl, halogen-substituted C1-C6alkoxy group, C3-C12cycloalkyl, phenyl, morpholinyl, pyrrolidinyl, piperidinyl, -XNR17R17, -XC(O)NR17R17, -XC(O)R19 and -XOXR19, where X denotes a bond or C1-C4alkylene; R17 is selected from a group which includes C1-C6alkyl, and R19 is selected from a group which includes C3-C12cycloalkyl, piperidinyl and phenyl. The invention also relates to use of the disclosed compounds to prepare a medicinal agent which modulates PPARδ activity, a pharmaceutical composition having PPARδ activity modulating properties, which contains a therapeutically effective amount of the disclosed compound and to use of the pharmaceutical composition in preparing a medicinal agent which modulates PPARδ activity.

EFFECT: improved properties of compounds.

10 cl, 1 tbl, 69 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry, in particular to composition for prevention and treatment of diseases and states, associated with platelet aggregation and platelet-induced thrombosis, including mixture of at least one flavonoid with free B-cycle, of at least one flavane and at least one agent, selected from group, consisting of injection anticoagulant agent, peroral anticoagulant agent, antiplatelet agent, anti-angina medication, non-steroid anti-inflammatory drug (NSAID) or selective cyclooxygenase-2 (COX-2) inhibitor (versions). Method of composition application.

EFFECT: compositions are efficient for prevention and treatment of diseases and states, associated with platelet aggregation and platelet-induced thrombosis.

32 cl, 14 tbl, 11 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to derivatives of 5,7-disubstituted [1,3]thiazolo[4,5-d]pyrimidine-2(3H)-one of formula (I) where R1 represents CH3 or CH3CH2; R2 represents H, 3-CN, 2-CF3, 2-F, 3-F, 3-CF3, 3-CONH2 or SO2CH3; R3 represents H; R4 represents H or CH3; and R5 represents H; or, when R4 represents CH3, R5 represents H or F; and to its pharmaceutically acceptable salts. Also, the invention refers to a pharmaceutical composition exhibiting properties of CX3CR1 receptor antagonist containing compound (I) of formula or its pharmaceutically acceptable salt mixed with a pharmaceutically acceptable diluent or carrier.

EFFECT: enabled administration of the derivatives of 5,7-disubstituted [1,3]thiazolo[4,5-d]pyrimidine-2(3H)-one as selective CX3CR1 receptor antagonists.

13 cl, 1 tbl, 20 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine and can be used for treating body system involvements caused by activated peroxidation. There is a liquid pharmaceutical composition offered therefore containing 2-ethyl-6-methyl-3-hydroxypyridine succinate, surface active substances and a sulphite stabiliser in a certain ratio. The composition is suggested to be introduced sublingually in the form of a spray.

EFFECT: composition is characterised by high storage stability and improved efficacy enabling an effect similar to such provided by an injection formulation, with a substantially smaller dose of an active agent.

9 cl, 6 tbl, 5 ex

FIELD: chemistry.

SUBSTANCE: invention relates to novel 5,7-diamino-substituted pyrazolo[1,5-a]pyrimidines selected from specific compounds, e.g. those given below, which have cyclin-dependent kinase inhibiting properties, such as CDK2. The compounds can be used to treat diseases and conditions associated with CDK, such as proliferative diseases, leukaemia.

.

EFFECT: more effective use of the compounds.

12 cl, 87 tbl, 1057 ex

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