Method of reduction of spontaneous erythrocyte aggregation in case of arterial hypertension with metabolic syndrome

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to cardiology, hematology, and can be applied for reduction of spontaneous erythrocyte aggregation in case of arterial hypertension with metabolic syndrome. For this purpose administered are dosed static and dynamic physical activity, daily swimming for not less than 40 min. per day in the middle of the day, as well as lisinopril in dose 10 mg 1 time per day in the morning and methformin 500 mg 2 times per day. Physical activity includes morning hygienic gymnastics, therapeutic-preventive gymnastics and divided physical exercises during the day. Treatment course is 2 months.

EFFECT: combination of treatment methods makes it possible to reduce spontaneous erythrocyte aggregation, which assists prevention of thrombotic complications in said category of patients.

2 ex

 

The invention relates to medicine, namely to Hematology and cardiology.

Analogues of the proposed method of reducing the spontaneous aggregation of erythrocytes (SAE) in patients with arterial hypertension (AH) with metabolic syndrome (MS) does not exist.

For the correction of arterial hypertension is often prescribed ACE inhibitors, including lisinopril for the correction of metabolic disorders in MS, can sometimes prescribed Metformin, in the correction pattern AH patients with MS may include a low-calorie diet, physical exercise and swimming.

In preparing this proposal was tasked to develop an effective and affordable way to reduce aggregation of erythrocytes in patients with MS, which would solve the problem of correction of arterial hypertension and MS with simultaneous normalization of SAE and thereby prevention in a wide range of patients with hypertension with MS development of myocardial infarction, cerebral stroke and thrombosis of different localization.

When ever medical complex, consisting of individually low-calorie diet, individually tailored physical training, swimming and drugs lisinopril and Metformin has been used in patients with MS to normalize SAE.

The aim of the invention is to increase the efficiency of correction of violations SAE in patients with MS.

usnot the proposed method is for correction SAE sick AG with MS long is assigned a complex of low-calorie diet, exercise workouts, daily swimming at least 40 minutes a day in the middle of the day and drugs lisinopril at a dose of 10 mg 1 time a day, morning and Metformin 500 mg 2 times a day.

The method allows to correct SAE in patients with MS within 2 months, translating it to a level close to that of healthy people. Subject to the subsequent recommendations of the proposed method can be maintained SAE, and therefore, the rheology of blood in an optimal state, which will significantly reduce the risk of thrombotic complications, reduce the number of cases of temporary disability, to accelerate and improve the quality of patient treatment, reduce disability, and also to prolong the life and reduce mortality of patients with arterial hypertension with mortality from heart attack, stroke and thrombosis of different localization.

The inventive method is carried out as follows. Taking 9 ml of blood is produced in the morning after a 14 hour fast from Vienna through the thick needle by gravity into a test tube with sodium citrate in the ratio of 9:1 to assess the aggregation of erythrocytes.

Erythrocyte aggregation is assessed by the degree of ability of erythrocytes to spontaneously aggregate (Pokrova O.A., Grineva MR, Ivanov K.S. Methodology and clinical significance of study the rheological properties of blood.//Bulletin of the Ivanovo medical Academy. - 2008. - V.13, №1-2. - S.89-98).

To assess the aggregation of erythrocytes blood from a vein taken in sodium citrate in the ratio of 9:1 and centrifuged 10 min at 3000 rpm./minutes In 96 hole taken to fill 2 holes 0.2 ml plasma of the subject. From the tube removed all the plasma and the layer of leukocytes. Erythrocytes resuspended standard phosphate buffer in the ratio 1:4, followed by centrifugation for 10 min at 3000 rpm./min, allowing you to wash them from the remnants of the plasma when removing the supernatant. After this is taken as 0.02 ml of erythrocytes and resuspended first filled with autologous plasma hole hole 96 Ouija boards, allowing you to get 10% hematocrit. Then from this hole, take a clean, dry pipette 0,02 ml content and placed in the second filled the hole that allows you to get 1% hematocrit. After that 1 grid in the camera Goryaeva fill obtained a suspension of erythrocytes incubated 3 min for the occurrence of spontaneous aggregation and shall count free erythrocytes (including 2 of the erythrocyte together) and units, starting with 3 cells, connected in the form of "monetary columns") in 2 large squares of the camera (lens ×40, eyepiece ×10). Considered the number of "coin of columns and the number of red blood cells, involved in them.

Based on these results, calculate the following indicators, assessed the existing SAE:

1) Average unit size (CPA):

CPA=sea/KA

Sea - the sum of all cells in the units;

KA - the number of units.

2) the Index of aggregation (PA):

PA=(PA·KA+CTU)/(KA+CTU)

CTU - free erythrocytes.

3) the Percentage of non-aggregated RBCs (PNA):

PNA=CSE·100/(PA·KA+CSP).

Normative values for CPA are 4-5, PA 1,05-1,30, for the PNA 80,0-92,0%. The increase in CPA above 5, and PA above 1.30 and lowering the PNA below 80,0% talks about increasing the SAE. In case of violation of at least one of these three indicators of sick AG with MS should be treated according to the inventive method.

To create a negative energy balance in the body, patients are advised individually selected low-calorie diet.

Calorie daily diet for each individual AG with MS is calculated in kcal by the formula:

for women 18-30 years (0,0621×body weight (kg)+2,0357)×240,

31-60 years (0,0342×body weight (kg)+3,5377)×240,

over 60 years of age (0,0377×body weight (kg)+2,7545)×240,

for men 18-30 years (0,0630×body weight (kg)+2,8957)×240,

31-60 years (0,0484×body weight (kg)+3,6534)×240,

over 60 years of age (0,0491×body weight (kg)+2,4587)×240.

The resulting coefficient remains unchanged with minimal physical activity, multiplied by 1.3 in moderate and 1.5 - high physical activity (usually in patients SMS physical activity level low).

It is recommended that three main meals and two intermediate. With regular skipping one meal significantly increases the incidence of obesity, also revealed a positive correlation between obesity and skipping Breakfast. It is recommended that the following distribution of daily calories: Breakfast - 25%, 2nd Breakfast - 10%, lunch - 35%, tea - 10%, dinner - 20%.

To compile menu the patient uses a special table with the instructions of the chemical composition and caloric content of products, given that the main sources of energy: protein (1 g contains 4 kcal), fat (9 kcal), carbohydrates (4 kcal) and alcohol (7 kcal).

The second component of the proposed method is feasible regular physical exercise.

In real life you can implement the three forms of physical activity: 1) morning hygienic gymnastics (charging); 2) health care gymnastics; 3) fractional exercise during the day.

1. Morning hygienic gymnastics (charging).

Morning gymnastics should do after waking up to Breakfast in a ventilated room. Under the influence of training the body is released from the state of inhibition of the physiological processes taking place during sleep.

The sequence of the exercises involves the alternation of load on different m the muscle groups (arms, legs and body). Exercises are performed with gradually increasing excursion breathing, stretching, limited applied power conditions. Breathing exercise should be free, rhythmic, without delay, mainly through the nose; the exhalation should be longer than the inhale (breath in 2-3 sec, exhale 3-5).

In good health the load, you can increase the number of repetitions faster, increase range of motion and shorter pauses between exercises.

When fatigue should reduce the load, increase the duration of pauses between exercises; to fill their quiet breathing.

After gymnastics, you must go to the rubbing or take a shower.

Morning exercises should evoke a sense of vitality, increased activity, improved health and performance.

If you feel unwell, develop shortness of breath or pain in the heart and behind the sternum should be temporarily suspend classes and consult a doctor.

During the day, sick AG with MS recommended treatment and preventive exercises. Depending on the initial fitness may apply at the beginning of the lightweight option, physical activity, and subsequently enhanced option.

2. Complexes of preventive and curative gymnastics for persons suffering from hypertension with MS.

2.1. Lightweight version of treatment and prevention is th gymnastics.

Exercise 1. Standing. A quiet walk with a gradual acceleration and deceleration 1-2 minutes on the exercise of the gradual deepening of the breath.

Exercise 2. Circular motion in the shoulder joints. When breeding - breath, when the note - exhale with a slight tilt of the torso and retraction of the abdominal wall 6-8 times. The fingers touch the shoulders, elbows close to the torso.

Exercise 3. Standing, hands on his belt. Alternately shifting the weight of the body from one foot to the other with a small bending the legs at the knee joint without lifting the feet from the floor. Exercise done 10-16 times with the muscles of the legs.

Exercise 4. Standing, feet apart at shoulder width, hands on his belt. Bending the trunk forward, touch right hand to left toe. 4-6 times alternately. When straightened position - breath, when the tilt - exhale. To look ahead.

Exercise 5. Standing with arms along the body. At the same time to take straight arm and one leg to the side with alternating lead leg. 4-6 times in each direction in turn. A wave of the hands and feet, breathe freely, do not delay.

Exercise 6. Standing, feet apart, hands in front of chest with palms down. With a turn of the body to dissolve hand in hand with turning the palms up - breath. To return to the original position with a small tilting forward, exhale. 3-5 times in each direction in turn. Breath to agree with the movement to the receiving corps and hands. By the end of exhalation to engage the wall of the abdomen.

Exercise 7. Standing, hands free. The walk free - 1 min, then with high flexion of the hips - 10-20 movements with subsequent transition to a peaceful walk 1-2 minutes Breathing rhythmic, medium depth.

Exercise 8. Sitting on the edge of the chair, hands on the waist. The bowing of the back and bending forward of the body. Repeat 6-10 times. Breathing is not to delay.

Exercise 9. Sitting on the edge of the chair, the emphasis tassels on the edge of a chair, and your feet slightly in front of the chair. Squats with a focus hands on the edge of a chair - 4-6 times. When you squat exhale.

Exercise 10. Standing sideways to the back of the chair to hold it with one hand. Swing free straight arm with leg pulling back. To return to the original position. Repeat 4-6 times for each leg and arm. Breathing is not to delay.

Exercise 11. Standing, legs apart widely, hands on waist. Turns the body right and left - 6-10 times alternately. The head does not turn, to look forward.

Exercise 12. Standing, feet together, hands down. Move the hands to the sides, inhale, bend the leg at the knee and pressed his hands to his stomach exhale. 3-5 times each leg alternately. Strive to maintain balance, on the exhalation, draw your abdomen.

Exercise 13. Standing, feet together, hands pubescent. The side slopes of the case with flexion of the opposite hand ("pump"). Breathing is not to delay, to strive to bolshehekstsirskiy movement.

Exercise 14. Standing. The walk is quiet with a steady breath average depth of 1-2 minutes

Exercise 15. Lying on the Mat to put under your head with a pillow. Go to a half-sitting position and bent to hug the hips, exhale, return to the starting position and inhale. Breath hold. Strive in a semi-sitting position to maintain balance. Run 4-6 times.

Exercise 16. Lying down, arms at sides, legs apart. A semi-circular motion right straight leg to the left with the rotation of the pelvis - exhale - return to the starting position and inhale. 3-5 times in each direction. Alternately left and right, with the greatest possible excursion movement of the leg, keeping the emphasis brushes the floor.

Exercise 17. Sitting on the floor: (a) to stand on all fours; b) to move into position on his knees; hands up - breath, torso, and hands to take back - exhale. When the tilt pull the stomach. Repeat 4-6 times: d) to go into a standing position, and then in the supine position; (e) self-massage of the abdomen small polukrugom movements clockwise - 1-2 minutes Rest 2 min: W) quiet breathing; C) exercise the protrusion (calm) and retraction (active) abdominal wall. The retraction of the abdomen combined with exhale through the mouth. Repeat 4-6 times.

Exercise 18. Standing with arms bent. Energetic walking on the spot or area of high flexion of the hips and waving of hands - 20-30 step is. Breathing is not to delay.

Exercise 19. Sitting on a chair, legs apart, hands on the waist or rest against the edge of a chair. The circular motion of the pelvis with the retraction of the abdomen, when the abstraction of the pelvis ago by 4-6 times in each direction.

Exercise 20. Standing: a quiet walk with the breath of the average depth of 2-3 minutes

When the source sufficient trained or arising in the course of the practice of tolerance to physical loads, you can use the following set of exercises.

2.2. Enhanced preventive and curative gymnastics.

Exercise 1. Standing, walking, relaxing with rubbing the palms of the thorax, abdomen, lower back. Runs 1-2 minutes

Exercise 2. Standing, hands down. Simultaneous bending with tension and free "throwing" hand forward, sideways and upwards of 12-16 times. When you bend exhale, when the alignment of breath.

Exercise 3. Standing, hands on waist, legs shoulder-width apart. Lateral motion of the pelvis to the right and left, back and forth. Is 6-10 times alternately. Breathe freely.

Exercise 4. Standing, feet shoulder-width apart, hands pubescent. Circular motion direct hand in the shoulder joints, 6-10 times with a maximum excursion, breathing, do not delay.

Exercise 5. Standing, hands in front of chest, bent at the elbows. Walking with high flexion of the hips, with a touch of the hand. 6 to 10 times for each leg alternately. The movement is of energetic, when hip flexion - exhale through the mouth.

Exercise 6. The quiet walk 1-2 minutes

Exercise 7. Sitting on the edge of the chair, hands on the waist. Bending and bowing of the body. The exercise is performed 8-10 times. The energetic movement. When straightening - breath, bending exhale.

Exercise 8. Standing sideways to the chair, to hold back, the other hand on the waist. Alternate sweeps straight leg forward, with the greatest possible tour. Swing legs to be combined with the exhalation. Runs 4-6 times.

Exercise 9. Standing, feet apart, hands at sides. Bending the body forward, touch right brush left toe of the feet, the other hand is allotted up. To return to the original position. Tilt combined with exhalation, by straightening the breath by 4-6 times.

Exercise 10. Walking the quiet breathing of the average depth of 1-2 minutes

Exercise 11. Standing, hands in a fist and lowered: (a) bending of the arms at the elbows with the power and extension of their diverting ago, with possibly large rectification and voltage and delay in the stress state within 2-3 C. Standing, hands on waist; b) proprietary with subsequent lifting in socks and tension legs. The exercise is performed 4-6 times with possibly large rectification and voltage, and the delay in the stress state within 2-3 C.

Exercise 12. Sitting on the edge of the chair. In the raised position and bent knee leg made TLAT alternately shaking the hands of the calf muscles and thighs. To reduce muscle tension. 1-2 minutes

Exercise 13. Sitting on the edge of the chair, straight leg divorced. Pinch open and direct the hands and feet. When breeding breath, when the note - exhale. Is 4-8 times.

Exercise 14. Standing, walking, relaxing with the transition to the rhythmic quiet running (Jogging) on the spot or moving. For fatigue to go on a peaceful walk with the breath of the average depth of 2-5 minutes

Exercise 15. Lying on the Mat. Simultaneous lifting of the body and legs on the exhale 4-6 times. Arms and legs should be straight, to keep the balance.

Exercise 16. Lying on the Mat, the emphasis brushes the floor. Cross movement straight leg - scissors 4-8 times. Breathing is not to delay.

Exercise 17. With a quick straightening of the legs to move into a sitting position, then to lie down. You can help stroke 4-6 times.

Exercise 18. Lying on your back, legs bent. Calm breathing 4-6 times.

Exercise 19. Lying on his back, hands diluted with emphasis brushes the floor. With the rotation of the pelvis to the left, bend the legs, rotate the pelvis with legs crossed to the right and stretch the legs. To repeat such a circular motion feet 3-6 times in each direction alternately. Hands not off the floor. Breathing is not to delay.

Exercise 20. Lying on your back, arms and legs separated. Alternate turns the body right and left laying one hand to the other. Feet are not slipping. the ri divorced hands breath, turning exhale. Performed 3-6 times.

Exercise 21. Lying on your back, arms along the body: a) turn on your left side; b) to turn on the right side; C) switch to lying on his stomach; to kneel; d) to move in a standing position; (e) walking on the spot with high flexion of the hips and the movement of the hand - 20-30 steps; g) to sit on the Mat; C) lie on your back, relaxing breath. The whole complex repeat 3-4 times.

Exercise 22. Standing, walking the quiet breathing of the average depth of 1-2 minutes

Exercise 23. Standing, feet apart on the width of the foot, hands on waist. Circular motion of the pelvis, right and left 6-8 times. Breathing is not to delay.

Exercise 24. Standing with legs wide apart, hands in front of chest. Alternately bending, leg with the transfer to it of gravity of the body with stretching hand to toe of the bent leg. 4-6 times in each direction. The other leg is straight. When straightening - breath, when the tilt - exhale.

Exercise 25. Standing, feet apart at shoulder width, hands on waist. Circular head movements by 4-10 times in each direction.

Exercise 26. Standing, feet apart at shoulder width, hands on waist. Bend trunk to the right, pulling the left arm up - breath. Return to starting position - exhale. 4-6 times alternately.

Exercise 27. The same hands to the shoulders. Circular motion of the brushes with the maximum excursion in the shoulder joints, when R is the. - breath during the mixing and retraction of the abdominal wall exhale. Breathing deep.

Exercise 28. Standing, peaceful walk and breath the average depth. The reduction of the total load for 1-2 minutes

3. Fractional exercise during the day.

Depending on the conditions of real life AH patients with MS can recommend various exemplary embodiments of the fractional loads to increase physical (motor) activity during the day.

Option 1.

Exercise 1. Sitting - dilute the elbows to the sides, inhale, extend hands forward voltage exhale 4-6 times.

Exercise 2. Sit - to stand with the deflection of the housing and land - 8-10 times.

Exercise 3. Sitting mimicking the movements of a boxer with possibly a large turn of the body is 10-12 times.

Option 2.

Exercise 1. Standing - walking with high flexion in the hip - 16-30 times.

Exercise 2. Standing - circular head movements to the right and left - 3-8 times in each direction.

Exercise 3. Standing legs apart widely imitated the movements of Costa - 10-12 times.

Exercise 4. Sitting - transition into the standing - 10-12 times.

Option 3.

Exercise 1. The quiet walk - 1 min

Exercise 2. Walking fast - 1 minute

Exercise 3. Walking with high flexion of the hips and alternate wave of the hands 20-30 times.

Exercise 4. Walking the quiet breathing of 1-2 min; quiet running on the spot or move around p is the displacement - 2-5 minutes

Option 4.

Walk the pedestrian varying length.

Option 5.

Physical work in different ways and with different duration depending on the conditions (cleaning, home services, cleaning, gardening work, and others).

The third component of the claimed method is a daily swim in the sea, the river or the pool at least 40 minutes a day in the middle of the day.

The fourth component of way of leveling advanced SAE in patients with MS is the appointment of lisinopril at a dose of 10 mg 1 time a day, morning and Metformin 500 mg 2 times a day.

Example 1. Patient K., 46 years old, suffering from hypertension with MS for 5 years, were examined during the follow up inspection regarding arterial hypertension. The patient was taken to the blood in a plastic tube with subsequent study of the aggregation activity of erythrocytes (CPA=5,5, PA=1,62, PNA=64,2%), indicating that the increase of the AOC.

The patient was recommended individually selected low-calorie diet, exercise load, swimming in the pool at least 40 minutes a day in the middle of the day, the reception of lisinopril 10 mg in the morning and Metformin 500 mg 2 times a day.

After 1.5 months found that the patient SAE (CPA=4,8, PA=1,18, PNA=82,9%) is normalized.

Example 2. Patient N., 54 years, suffering AG with MS for 9 the em surveyed during the follow up inspection regarding arterial hypertension. The patient was taken to the blood in a plastic tube with subsequent study of the aggregation activity of erythrocytes (CPA=6,1, PA=1,92, PNA=42.7 percent), indicating a sharp increase in the SAE and the risk of thrombosis.

The patient was recommended individually selected low-calorie diet, measured static and dynamic exercise, daily swimming at least 40 minutes a day in the middle of the day, lisinopril 10 mg in the morning and Metformin 500 mg 2 times a day.

After 2 months of treatment indicators aggregation of erythrocytes (CPA=4,8, PA=1,17, PNA=81,6%) normalized, indicating a normalization of the AOC of the patient.

The use of the proposed correction method SAE in Hematology and cardiology will help to avoid many of vascular complications in patients with MS, they reduce the number of cases of temporary disability, to reduce the duration of hospitalization, reduce morbidity and mortality.

The way to reduce the spontaneous aggregation of red blood cells in arterial hypertension with metabolic syndrome, including the use of individualized low-calorie diet, measured static and dynamic physical loads, which includes morning hygienic gymnastics, therapeutic gymnastics, etc the service of physical activities throughout the day, daily swim at least 40 minutes a day in the middle of the day, the reception of lisinopril at a dose of 10 mg 1 time a day, morning and Metformin 500 mg 2 times a day for 2 months.



 

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26 cl, 500 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: there is offered the administration of heparin conjugated with 2-aminoethanesulfonic acid (taurine) of formula (1), synthesised with a condensing reagent - water-soluble 1-ethyl-3[3 (dimethylamino)propyl]carbodiimide as an anti-inflammatory and antineoplastic anticoagulant.

EFFECT: compound surpasses heparin in anticoagulating ability, has high anti-inflammatory activity, while antineoplastic activity is comparable with the effect of antineoplastic preparations (doxorubicin, cyclophosphan, vincristine).

5 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology and cardiology, and concerns reducing spontaneous erythrocyte aggregation (SEA) in arterial hypertension with impaired glucose tolerance.. That is ensured by the integrated treatment that involves the administration of lisinopril 10 mg once a day in the morning and metformin 500 mg twice a day for 2 months, as well as graduated static and dynamic physical activity, including daily swimming for at least 30 minutes a day.

EFFECT: complex of drug-induced and drug-free modalities ensure reducing the SEA for 2 months that in turn promotes normalised blood rheology and reduced risk of thrombotic complications in the case patients.

2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine and can be used for determination of selection of heparin application for prevention of thrombotic complications. For this purpose level of soluble fibrin-monomer complexes is determined in blood plasma by means of ortho-phenantroline test. If its value is lower than 15.0 mg/100 ml transdermal way of heparin introduction is used. If the value is higher than 15.0 mg/100 ml parenteral way of heparin introduction is used.

EFFECT: method ensures efficient prevention of thrombotic complications due to selection of way of heparin introduction depending on degree of intravascular thrombus-formation.

4 tbl

FIELD: medicine.

SUBSTANCE: there are offered versions of a monoclonal antibody specific to GPVI polypeptide, peptide or its naturally occurred version. A based antithrombotic composition and a method for preparing thereof are described. The versions of methods for inhibition and treatment of various thrombocyte aggregation mediated diseases are disclosed. An antithrombotic set and hybridoma for producing the monoclonal antibody are described.

EFFECT: use of the invention provides the antibodies inhibiting thrombocyte aggregation that can find the further application in medicine for treating various thromboses.

13 cl, 16 dwg, 9 tbl, 10 ex

FIELD: chemistry.

SUBSTANCE: invention relates to 3-cyclohexylaminomethylthiazole[3,2-a]benzimidazole dihydrochloride of formula I: , having immunotropic and anti-aggregation activity.

EFFECT: novel compounds have useful biological properties.

2 cl, 8 tbl, 3 ex

FIELD: chemistry.

SUBSTANCE: invention relates to 3-methyl-8-piperazino-7-(thiethanyl-3)-1-ethylxanthine hydrochloride of formula .

EFFECT: novel compound which can be used in medicine as an antiaggregation and disaggregation agent is obtained and described.

3 cl, 2 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to hematology and cardiology. Method includes administration to patients of complex from hypocaloric diet, dosed static and dynamic physical activity, including morning hygienic gymnastics, preventive medical gymnastics, divided physical exercise throughout the day, daily swimming for not less than 30 min per day in the middle of the day, intake of lisinopril in dose 10 mg 1 time per day in the morning and simvastatin 20 mg 1 time per day in the morning during 2 months. Combined application of all components makes it possible to reduce SEA in patients with AH with AO and D, reducing it to the level close to such for healthy people, during 2 months of treatment.

EFFECT: reduction of spontaneous erythrocyte aggregation (SEA) in case of arterial hypertension (AH) with abdominal obesity (AO) and dyslipidemia (D).

2 ex

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