Method of reducing spontaneous erythrocyte aggregation in case of arterial hypertension with abdominal obesity and dyslipidemia

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to hematology and cardiology. Method includes administration to patients of complex from hypocaloric diet, dosed static and dynamic physical activity, including morning hygienic gymnastics, preventive medical gymnastics, divided physical exercise throughout the day, daily swimming for not less than 30 min per day in the middle of the day, intake of lisinopril in dose 10 mg 1 time per day in the morning and simvastatin 20 mg 1 time per day in the morning during 2 months. Combined application of all components makes it possible to reduce SEA in patients with AH with AO and D, reducing it to the level close to such for healthy people, during 2 months of treatment.

EFFECT: reduction of spontaneous erythrocyte aggregation (SEA) in case of arterial hypertension (AH) with abdominal obesity (AO) and dyslipidemia (D).

2 ex

 

The invention relates to medicine, namely to Hematology and cardiology.

Analogues of the proposed method of reducing the spontaneous aggregation of erythrocytes (SAE) in patients with arterial hypertension (AH) with abdominal obesity (AO) and dyslipidemia (D) does not exist.

For the correction of arterial hypertension is often prescribed ACE inhibitors, including lisinopril for the treatment of D are used statins, including simvastatin, in the correction pattern of patients with different combinations of AG, AB and D, often includes a low-calorie diet, physical exercise and swimming.

In preparing this proposal was tasked to develop an effective and affordable way to reduce aggregation of erythrocytes in patients with AH, AO and D, which would solve the problem of correction of AG, AB and D with simultaneous normalization of SAE and thereby prevention in a wide range of patients with hypertension, AO and D development of myocardial infarction, cerebral stroke and thrombosis of different localization.

When ever medical complex, consisting of a low-calorie diet, individually tailored physical training, swimming in the pool and drugs lisinopril and simvastatin, were not used in patients with AH, AO and D to normalize SAE.

The aim of the invention is to increase the efficiency of correction of violations SAE in patients with AH, AO and D.

usnot the proposed method is for correction SAE patients with AH, AO and D. long-term is assigned a complex of low-calorie diet, exercise workouts, daily swimming for at least 30 min a day in the middle of the day and drugs lisinopril at a dose of 10 mg 1 time a day, morning and simvastatin 20 mg 1 time in the evening after a meal.

The method allows to correct SAE in patients with AH, AO and D for 2 months, translating it to a level close to that of healthy people. Subject to the subsequent recommendations of the proposed method can be maintained SAE, and therefore, the rheology of blood in an optimal state, which will significantly reduce the risk of thrombotic complications, reduce the number of cases of temporary disability, to accelerate and improve the quality of patient treatment, reduce disability, and also to prolong the life and reduce the mortality rate of patients with AH, AO and D from a heart attack, stroke and thrombosis of different localization.

The inventive method is carried out as follows. Taking 9 ml of blood is produced in the morning after a 14-hour fast from Vienna through the thick needle by gravity into a test tube with sodium citrate in the ratio of 9:1 to assess the aggregation of erythrocytes.

Erythrocyte aggregation is assessed by the degree of ability of erythrocytes to spontaneously aggregate (Pokrova O.A., Grineva MR, Ivanov K.S. Methodology and clinical mn is the significance of the study the rheological properties of blood // Bulletin of the Ivanovo medical Academy. - 2008. - T13, No. 1-2. - S.89-98).

To assess the aggregation of erythrocytes blood from a vein taken in sodium citrate in the ratio of 9:1 and centrifuged 10 min at 3000 rpm/min In 96-well pad fill 2 holes 0.2 ml plasma of the subject. From the tube removed all the plasma and the layer of leukocytes. Erythrocytes resuspendiruetsa standard phosphate buffer in the ratio 1:4, followed by centrifugation for 10 min at 3000 rpm, allowing you to wash them from the remnants of the plasma when removing the supernatant. After this is taken as 0.02 ml of erythrocytes and resuspended first filled with autologous plasma-well 96-well Ouija boards, allowing you to get 10% hematocrit. Then from this hole, take a clean, dry pipette 0,02 ml content and placed in the second filled the hole that allows you to get 1% hematocrit. After that 1 grid in the camera Goryaeva fill obtained a suspension of red blood cells, incubated 3 min for the occurrence of spontaneous aggregation and shall count free erythrocytes (including 2 of the erythrocyte together) and units, starting with 3 cells, connected in the form of "monetary columns", 2 large squares of the camera (lens×40, eyepiece×10). Considered the number of "coin of columns and the number of red blood cells, involved in them.

Based on these results, calculate the following indicators, pricing the e SAE:

1) Average unit size (CPA):

CPA=sea/KA

Sea - the sum of all cells in the units;

KA - the number of units.

2) the Index of aggregation (PA):

PA=(CPA·KA+CTU)/(KA+CTU)

CTU - free erythrocytes.

3) the Percentage of non-aggregated RBCs (PNA):

PNA=CSE·100/(CPA·KA+CTU)

Normative values for CPA are 4-5, PA 1,05-1,30, for the PNA 80,0-92,0%. The increase in CPA above 5, and PA above 1.30 and lowering the PNA below 80,0% talks about increasing the SAE. In case of violation of at least one of these three indicators of sick AG, AB and D must be treated according to the claimed method.

To create a negative energy balance in the body, patients are advised individually selected low-calorie diet.

Calorie daily diet individually for each patient is calculated in kcal by the formula:

for women 18-30 years (0,0621×body weight (kg)+2,0357)×240,

31-60 years (0,0342×body weight (kg)+3,5377)×240,

over 60 years of age (0,0377×body weight (kg)+2,7545)×240,

for men 18-30 years (0,0630×body weight (kg)+2,8957)×240,

31-60 years (0,0484×body weight (kg)+3,6534)×240,

over 60 years of age (0,0491×body weight (kg)+2,4587)×240.

The resulting coefficient remains unchanged with minimal physical activity, multiplied by 1.3 in moderate and 1.5 - high physical activity (as a rule, the patient is s physical activity level low).

Recommended 3 main meals and 2 intermediate. With regular skipping one meal significantly increases the incidence of obesity, also revealed a positive correlation between obesity and skipping Breakfast. It is recommended that the following distribution of daily calories: Breakfast - 25%, 2nd Breakfast - 10%, lunch - 35%, tea - 10%, dinner - 20%.

To compile menu the patient uses a special table with the instructions of the chemical composition and caloric content of products, given that the main sources of energy: protein (1 g contains 4 kcal), fat (9 kcal), carbohydrates (4 kcal) and alcohol (7 kcal).

The second component of the proposed method is feasible regular physical exercise.

In real life you can implement the three forms of physical activity: 1) morning hygienic gymnastics (charging); 2) health care gymnastics; 3) fractional exercise during the day.

1. Morning hygienic gymnastics (charging)

Morning gymnastics should do after waking up to Breakfast in a ventilated room. Under the influence of training the body is released from the state of inhibition of the physiological processes taking place during sleep.

The sequence of the exercises involves the alternation of load on different mysen the e group (hands, legs and body). Exercises are performed with gradually increasing excursion breathing, stretching, limited use of power conditions. Breathing exercise should be free, rhythmic, without delay, mainly through the nose; the exhalation should be longer than the inhale (breath in 2-3 sec, exhale 3-5).

In good health the load, you can increase the number of repetitions faster, increase range of motion and shorter pauses between exercises.

When fatigue should reduce the load, increase the duration of pauses between exercises, to fill their quiet breathing.

After gymnastics, you must go to the rubbing or take a shower.

Morning exercises should evoke a sense of vitality, increase activity, improve well-being and health.

If you feel unwell, develop shortness of breath or pain in the heart and behind the sternum should be temporarily suspend classes and consult a doctor.

During the day, sick AG, AB and D is the recommended treatment and preventive exercises. Depending on the initial fitness may apply at the beginning of lightweight option exercise, then the enhanced version.

2. Complexes of preventive and curative gymnastics for persons suffering from hypertension with AO and D.

2.1. Lightweight version of curative-preventive care is practical gymnastics

Exercise 1. Standing. A quiet walk with a gradual acceleration and deceleration 1-2 minutes on the exercise of the gradual deepening of the breath.

Exercise 2. Circular motion in the shoulder joints. When breeding - breath, when the note - exhale with a slight tilt of the torso and retraction of the abdominal wall 6-8 times. The fingers touch the shoulders, elbows close to the torso.

Exercise 3. Standing, hands on his belt. Alternately shifting the weight of the body from one foot to the other with a small bending the legs at the knee joint without lifting the feet from the floor. Exercise done 10-16 times with the muscles of the legs.

Exercise 4. Standing, feet apart at shoulder width, hands on his belt. Bending the trunk forward, touch right hand to left toe. 4-6 times alternately. When straightened position - breath, when the tilt - exhale. To look ahead.

Exercise 5. Standing with arms along the body. At the same time to take straight arm and one leg to the side with alternating lead leg. 4-6 times in each direction in turn. A wave of the hands and feet, breathe freely, do not delay.

Exercise 6. Standing, feet apart, hands in front of chest with palms down. With a turn of the body to dissolve hand in hand with turning the palms up - breath. To return to the original position with a small tilting forward, exhale. 3-5 times in each direction in turn. Breath to agree with the movement to the receiving corps and hands. By the end of exhalation to engage the wall of the abdomen.

Exercise 7. Standing, hands free. The walk free -1 min, then with high flexion of the hips - 10-20 movements with subsequent transition to a peaceful walk 1-2 minutes Breathing rhythmic, medium depth.

Exercise 8. Sitting on the edge of the chair, hands on the waist. The bowing of the back and bending forward of the body. Repeat 6-10 times. Breathing is not to delay.

Exercise 9. Sitting on the edge of the chair, the emphasis tassels on the edge of a chair, and your feet slightly in front of the chair. Squats with a focus hands on the edge of a chair - 4-6 times. When you squat exhale.

Exercise 10. Standing sideways to the back of the chair to hold it with one hand. Swing free straight arm with leg pulling back. To return to the original position. Repeat 4-6 times for each leg and arm. Breathing is not to delay.

Exercise 11. Standing, legs apart widely, hands on waist. Turns the body right and left - 6-10 times alternately. The head does not turn, to look forward.

Exercise 12. Standing, feet together, hands down. Move the hands to the sides, inhale, bend the leg at the knee and pressed his hands to his stomach exhale. 3-5 times each leg alternately. Strive to maintain balance; on the exhale, draw your abdomen.

Exercise 13. Standing, feet together, hands down. The side slopes of the case with flexion of the opposite hand ("pump"). Breathing is not to delay, to strive for greater e is scurvy movement.

Exercise 14. Standing. A quiet walk with a uniform average depth of breathing. 1-2 minutes

Exercise 15. Lying on the Mat to put under your head with a pillow. Go to a half-sitting position and bent to hug the hips, exhale, return to the starting position and inhale. Breath hold. Strive in a semi-sitting position to maintain balance. Run 4-6 times.

Exercise 16. Lying down, arms at sides, legs apart. A semi-circular motion right straight leg to the left with the rotation of the pelvis - exhale - return to the starting position and inhale. 3-5 times in each direction. Alternately left and right, with the greatest possible excursion movement of the leg, keeping the emphasis brushes the floor.

Exercise 17. Sitting on the floor; a) to stand on all fours; b) to move into position on his knees; hands up - breath, torso, and hands to take back - exhale. When the tilt pull the stomach. Repeat 4-6 times; d) to go into a standing position, and then in the supine position; (e) self-massage of the abdomen small polukrugom movements clockwise - 1-2 minutes Rest 2 min; W) quiet breathing; C) exercise the protrusion (calm) and retraction (active) abdominal wall. The retraction of the abdomen combined with exhale through the mouth. Repeat 4-6 times.

Exercise 18. Standing with arms bent. Energetic walking on the spot or area of high flexion of the hips and waving of hands - 20-30 step is. Breathing is not to delay.

Exercise 19. Sitting on a chair, legs apart, hands on the waist or rest against the edge of a chair. The circular motion of the pelvis with the retraction of the abdomen when moving the pelvis back. 4-6 times in each direction.

Exercise 20. Standing. A peaceful walk with the breath of the average depth of 2-3 minutes

When the source sufficient trained or arising in the course of the practice of tolerance to physical loads, you can use the following set of exercises.

2.2. Enhanced preventive and curative gymnastics.

Exercise 1. Standing. The quiet walk with rubbing the palms of the thorax, abdomen, lower back. Runs 1-2 minutes

Exercise 2. Standing, hands down. Simultaneous bending with tension and free "throwing" hand forward, sideways and upwards of 12-16 times. When you bend exhale, when the alignment of breath.

Exercise 3. Standing, hands on waist, legs shoulder-width apart. Lateral motion of the pelvis to the right and left, back and forth. Is 6-10 times alternately. Breathe freely.

Exercise 4. Standing, feet shoulder-width apart, hands down. Circular motion direct hand in the shoulder joints, 6-10 times with a maximum excursion, breathing, do not delay.

Exercise 5. Standing, hands in front of chest, bent at the elbows. Walking with high flexion of the hips, with a touch of the hand. 6 to 10 times for each leg alternately. Movement is Oia, energetic, when hip flexion - exhale through the mouth.

Exercise 6. The quiet walk 1-2 minutes

Exercise 7. Sitting on the edge of the chair, hands on the waist. Bending and bowing of the body. The exercise is performed 8-10 times. The energetic movement. When straightening - breath, bending exhale.

Exercise 8. Standing sideways to the chair, to hold back, the other hand on the waist. Alternate sweeps straight leg forward, with the greatest possible tour. Swing legs to be combined with the exhalation. Runs 4-6 times.

Exercise 9. Standing, feet apart, hands at sides. Bending the body forward, touch right brush left toe of the feet, the other hand is allotted up. To return to the original position. Tilt combined with exhalation, by straightening the breath by 4-6 times.

Exercise 10. Walking the quiet breathing of medium depth. 1-2 minutes

Exercise 11. Standing, hands in a fist and lowered: (a) bending of the arms at the elbows with the power and extension of their diverting ago, with possibly large rectification and voltage and delay in the stress state within 2-3 C. Standing, hands on waist; b) proprietary with subsequent lifting in socks and tension legs. The exercise is performed 4-6 times with possibly large rectification and voltage, and the delay in the stress state within 2-3 C.

Exercise 12. Sitting on the edge of the chair. In the raised position and bent knee leg made TLAT alternately shaking the hands of the calf muscles and thighs. To reduce muscle tension. 1-2 minutes

Exercise 13. Sitting on the edge of the chair, straight leg divorced. Pinch open and direct the hands and feet. When breeding breath, when the note - exhale. Is 4-8 times.

Exercise 14. Standing. The quiet walk with the transition to the rhythmic quiet running (Jogging) on the spot or moving. For fatigue to go on a peaceful walk with the breath of medium depth. 2-5 minutes

Exercise 15. Lying on the Mat. Simultaneous lifting of the body and legs on the exhale. 4-6 times. Arms and legs should be straight, to keep the balance.

Exercise 16. Lying on the Mat, the emphasis brushes the floor. Cross movement straight leg - scissors. 4-8 times. Breathing is not to delay.

Exercise 17. With a quick straightening of the legs to move into a sitting position, then to lie down. You can help stroke 4-6 times.

Exercise 18. Lying on your back, legs bent. Calm breathing 4-6 times.

Exercise 19. Lying on his back, hands diluted with emphasis brushes the floor. With the rotation of the pelvis to the left to bend the legs, rotate the pelvis with legs crossed to the right and stretch the legs. To repeat such a circular motion feet 3-6 times in each direction alternately. Hands not off the floor. Breathing is not to delay.

Exercise 20. Lying on your back, arms and legs separated. Alternate turns the body right and left laying one hand to the other. Legs not smesiteli divorced hands breath, turning exhale. Performed 3-6 times.

Exercise 21. Lying on your back, arms along the body: a) turn on your left side; b) to turn on the right side; C) switch to lying on his stomach; to kneel; d) to move in a standing position; (e) walking on the spot with high flexion of the hips and the movement of the hand - 20-30 steps; g) to sit on the Mat; C) lie on your back, relaxing breath. The whole complex repeat 3-4 times.

Exercise 22. Standing. Walking the quiet breathing of the average depth of 1-2 minutes

Exercise 23. Standing, feet apart on the width of the foot, hands on waist. Circular motion of the pelvis, right and left 6-8 times. Breathing is not to delay.

Exercise 24. Standing with legs wide apart, hands in front of chest. Alternately bending the legs with the transfer to it of gravity of the body with stretching hand to toe of the bent leg. 4-6 times in each direction. The other leg is straight. When straightening - breath, when the tilt - exhale.

Exercise 25. Standing, feet apart at shoulder width, hands on waist. Circular head movements by 4-10 times in each direction.

Exercise 26. Standing, feet apart at shoulder width, hands on waist. Bend trunk to the right, pulling the left arm up - breath. Return to starting position - exhale. 4-6 times alternately.

Exercise 27. The same hands to the shoulders. Circular motion of the brushes with the maximum excursion in the shoulder joints, when RA is doing - breath during the mixing and retraction of the abdominal wall exhale. Breathing deep.

Exercise 28. Standing. A peaceful walk and breath the average depth. The reduction of the total load for 1-2 minutes

3. Fractional exercise during the day

Depending on the conditions of real life in patients with hypertension, AO and D can be recommended to various exemplary embodiments of the fractional loads to increase physical (motor) activity during the day.

Option 1

Exercise 1. Sitting - dilute the elbows to the sides, inhale, extend hands forward voltage exhale, 4-6 times.

Exercise 2. Sit - to stand with the deflection of the housing and land - 8-10 times.

Exercise 3. Sitting mimicking the movements of a boxer with possibly a large turn of the body is 10-12 times.

Option 2

Exercise 1. Standing - walking with high flexion in the hip - 16-30 times.

Exercise 2. Standing - circular head movements to the right and left - 3-8 times in each direction.

Exercise 3. Standing legs apart widely imitated the movements of Costa - 10-12 times.

Exercise 4. Sitting - transition into the standing - 10-12 times.

Option 3

Exercise 1. The quiet walk - 1 min

Exercise 2. Walking fast - 1 minute

Exercise 3. Walking with high flexion of the hips and alternate wave of the hands 20-30 times.

Exercise 4. Walking calm, breathing 1-2 min; quiet running on the spot or moving popolini - 2-5 minutes

Option 4

Walk the pedestrian varying length.

Option 5

Physical work in different ways and with different duration depending on the conditions (cleaning, home services, cleaning, gardening work, and others).

The third component of the claimed method is a daily swim in the sea, the river or the pool at least 30 minutes a day in the middle of the day.

The fourth component of way of leveling advanced SAE in patients with AO and D is the appointment of lisinopril at a dose of 10 mg 1 time a day, morning and simvastatin 20 mg 1 time in the evening after a meal.

Example 1. Patient M., 46 years old, suffering from hypertension, JSC and On for 8 years, were examined during the follow up inspection regarding arterial hypertension. The patient was taken to the blood in a plastic tube with subsequent study of the aggregation activity of erythrocytes (CPA-5,2, PA-1,45, PNA - 73,8%), indicating that the increase of the AOC.

The patient was recommended a low-calorie diet, exercise load, swimming in the pool at least 30 minutes a day in the middle of the day, the reception of lisinopril 10 mg in the morning and simvastatin 20 mg 1 time in the evening after a meal.

After 1.5 months found that the patient SAE (CPA - 4,8, PA - 1,11, PNA was 86.7%) is normalized.

Example 2. Patient Y., 58 years, suffering AH, AO and D on protag the research Institute for 10 years, surveyed during the clinical examination for hypertension. The patient was taken to the blood in a plastic tube with subsequent study of the aggregation activity of erythrocytes (CPA - 6,3, PA - 1,96, the PNA was 45.6%), indicating a sharp increase in the SAE and the risk of thrombosis.

The patient was recommended a low-calorie diet, measured static and dynamic exercise, daily swimming for at least 30 min a day in the middle of the day, lisinopril 10 mg in the morning and simvastatin 20 mg 1 time in the evening after a meal.

After 2 months of treatment indicators aggregation of erythrocytes (CPA - 4,7, PA - 1,19, PNA - 83,6%) normalized, indicating a normalization of the AOC of the patient.

The use of the proposed correction method SAE in Hematology and cardiology will help to avoid many of the vascular complications in patients with hypertension, AO and D, to reduce their number of cases of temporary disability, to reduce the duration of hospitalization, reduce morbidity and mortality.

The way to reduce the spontaneous aggregation of red blood cells in arterial hypertension abdominal obesity and dyslipidemia, which includes the use of a low-calorie diet, measured static and dynamic physical loads, which includes morning hygienic gymnastics, therapeutic gymnastics, fractional exercise n the day, daily swim at least 30 minutes a day in the middle of the day, the reception of lisinopril at a dose of 10 mg 1 time a day, morning and simvastatin 20 mg 1 time in the evening after meals for 2 months.



 

Same patents:

FIELD: medicine.

SUBSTANCE: claimed is application of conjugate of heparin with lysine and ibuprofen of formula as anti-inflammatory medication with anticoagulant, antitumour and antimetastatic activity. Conjugate of heparin with lysine and ibuprofen, where R=So3H/Ac (30:70).

EFFECT: conjugate possesses anti-inflammatory activity, which is 1,4 times higher than ibuprofen activity, anticoagulant activity is comparable with pharmacopeia heparin, its antitumour activity being comparable with that of doxorubicin, cyclophosphane, vincristine, prednisolone with demonstration of antimetastatic activity.

6 tbl

FIELD: medicine.

SUBSTANCE: invention refers to veterinary science. A method involves feeding of 0.01% Phosphopag solution in a single dose 300.0 ml and Ecoe suspension in a single dose 250 mg/kg of body weight to newborn calves.

EFFECT: method allows recovering digestive system functioning, normalising blood rheology, normalising calves' growth and development.

2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to novel derivatives of 5-thioxylose of formula I

where radicals are described in the claim, as well as to a synthesis method thereof and use thereof as active substances in medicinal agents, especially for treating or preventing thrombosis or cardiac failure.

EFFECT: more effective treatment.

9 cl, 162 ex, 2 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry, in particular to composition for prevention and treatment of diseases and states, associated with platelet aggregation and platelet-induced thrombosis, including mixture of at least one flavonoid with free B-cycle, of at least one flavane and at least one agent, selected from group, consisting of injection anticoagulant agent, peroral anticoagulant agent, antiplatelet agent, anti-angina medication, non-steroid anti-inflammatory drug (NSAID) or selective cyclooxygenase-2 (COX-2) inhibitor (versions). Method of composition application.

EFFECT: compositions are efficient for prevention and treatment of diseases and states, associated with platelet aggregation and platelet-induced thrombosis.

32 cl, 14 tbl, 11 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely, to efferent methods in surgery, and can be used in treating peritonitis patients. That is ensured by prolonged venovenous hemofiltration. In 2 hours after the procedure started, through a catheter inserted in a subclavian vein or a abdominal aorta with using a peristaltic pump for 15 minutes 250 ml of HyperHAES solution is introduced.

EFFECT: method allows higher effectiveness of detoxification ensured by an effect of endotoxin redistribution in a vascular bed from an interstitial space owing to introducing the hydroxyethyl starch solution followed by endotoxin elimination from the vascular bed by hemofiltration.

1 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: there is disclosed an application of complex iron (III) compounds with poly-maltha, hydrogenated dextrins or maltodextrin oxidation products for reparing an oral drug for iron deficiencies in patients suffering a chronic inflammatory intestinal disease, particularly Crohn's disease and nonspecific ulcerative colitis. When having been administered, the declared drugs have not invoked oxidative stress in contrast to iron sulphate therapy.

EFFECT: declared compounds are well tolerable, provide high compliance.

8 cl, 1 dwg, 3 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to derivatives of 4-aminocarbonylpyrimidine of formula (I).

EFFECT: invention is applicable as P2Y12 receptor antagonists for treatment and/or prevention of diseases or disease states of peripheral vessels, as well as vessels, supplying internal organs, vessels of liver and kidneys, in treatment and/or prevention of cardiovascular and cerebrovascular diseases and states, associated with aggregation of platelets, including thrombosis in humans and mammals.

26 cl, 500 ex

FIELD: medicine.

SUBSTANCE: first hemodilution is performed by exfusion of undiluted autoblood. As volume-substituting component, applied is autoplasm, prepared by method of intermittent plasmapheresis at gestation term from 32 to 38 weeks. After achievement of surgical hemostasis reinfusion of prepared undiluted autoblood in amount 5-10 ml/kg of body weight is carried out. Method makes it possible to provide adequate compensation of operation blood loss by stabilisation of blood coagulation potential and restoration of erythrocyte population in blood stream.

EFFECT: prevention of risk of developing complications in case of predicted blood loss in course of delivery due to following specific sequence of taken measures.

3 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to anesthesiology and resuscitation, and can be used in states accompanied by massive blood loss. For this purpose, 5 and 3 days prior to a surgery, autoblood is sampled in amount 10 % of circulating blood volume (CBV) in each sampling to be divided on plasma and erythrocyte concentrate. For 5 preoperative days, iron preparations are administered in a therapeutic dose. Also, the surgery is preceded with analysing patient's fluid deficiency. 40 minutes prior to the surgery, 12.5 % dicynone 500 mg, one volume of autoplasma are introduced, and infusion of a rated dose of 5 % glucose and 6 % hydroxyethyl starch (HES) 500 ml is started. If the intraoperative blood loss is suggested to be 15-30 % of the CBV, additionally 6 % HES 250 ml, prednisolone in dosage 2-4 mg/kg of body weight and one volume of erythrocyte concentrate are administered. If the estimated intraoperative blood loss exceeds 30 % of the CBV, the second volumes of autoplasma and erythrocyte concentrate, another introduction of dicynone in the same dosage, 6 % HES 250 ml, prednisolone in dosage 7 - 10 mg/kg of body weight are required. Within 30 and 60 minutes after the surgery, dicynone is injected in the same dosage. 5 hours after the surgery, filter drainage fluid is returned. 6 hours after the surgery, coagulation time is determined, and if observing no hypocoagulation, Clexane is introduced in a preventive dose.

EFFECT: method allows to provide early activation of erythropoiesis combined with improved erythrocyte morphology and blood haemostatic function, considerably reduced risk of complications connected with massive transfusion of donor blood products, as well as prevented edema of interstitial spaces and development of multiple-organ-failure syndrome due to maintained effective transcapillary exchange.

5 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a method for preparing a microelement drug on the basis of an iron-dextrin complex. The method includes the following stages: mixed water-soluble iron (III) salt and one or more water-soluble salts containing other microelements, e.g., cobalt, copper, zinc, manganese and selenite, and low-molecular dextrin are neutralised before sedimentation of iron (III) hydroxide, alkalised to pH 9-11, heated up to complete resolution and neutralised with an acid. Then, membrane ultrafiltration procedure is used to purify the prepared colloidal iron-dextrin complex with microelement atoms deposited in a polymeric covalent lattice of iron (III) oxide, and to concentrate it.

EFFECT: method allows preparing high-effective high iron fixation polymicroelement drug ensuring the best effect in treating iron-deficient conditions and promoting immune system resistance.

3 cl, 2 dwg, 3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to the following compounds: N-(1-{4-[2-(1-acetylamino-ethyl)-1-ethyl-1H-imidazol-4-yl]-benzyl}-3-hydroxy-propyl)-3-chloro-4-(2,2,2,-trofluoro-1-methyl-ethoxy)-benzamide, N-(1-{4-[2-(1-methyl-1-hydroxy-ethyl)-1-ethyl-1H-imidazole-4-yl}-benzyl}-3-hydroxy-propyl)-3-chloro-4-(,2,2,2-trifluoro-1-methyl-ethoxy)-benzamide, N-(1-{4-[2-(1-hydroxy-1-methyl-ethyl)-1-methyl-1H-imidazole-4-yl]-benzyl}-3-hydroxy-propyl)-3-chloro-4-(2,2,2,-trifluoro-1-methyl-ethoxy)-benzamide, 3-chloro-N-[2-[(N,N-dimethylglicyl)amino]-1-({4-[8-(1-hydroxyethyl)imidazo[1,2-a]pyridine-2-yl]phenyl}methyl)ethyl]-4-[(1-methylethyl)oxy]benzamide, 3-chloro-N-(1-(2-(dimethylamino)acetamido)-3-(4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-4-isopropoxybenzamide, 3-chloro-N-(2-[(2-methylalanyl)amino]-1-{[4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl]methyl}ethyl)-4-[(1-methylethyl)oxy]benzamide, 3-chloro-N-[(3-hydroxy)-1-({4-[8-(1-hydroxyethyl)imidazo[1,2-a]pyridine-2-yl]phenyl}methyl)propyl]-4-[(1-methylethyl)oxy]benzamide, as well as to their pharmaceutically acceptable salts.

EFFECT: obtained compounds and salts can be used for treatment cell proliferative diseases and disorders by modulating activity of mitotic kinesin CENP-E.

26 cl, 102 ex, 7 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine and represents a method for making a substratum wherein: a compound exhibiting anticoagulant activity chosen from a group consisting of heparin, thrombomodulin, 4-methoxybenzolsulfonyl-Azp(PEG2000-Ome)-Pro-4-amidinobenzylamido, ATPT and hirudin, and a hydrophilic compound chosen from a group consisting of PVA, PVP, PEG, PPG, a material consisting of polyether and polysiloxane, polyethyleneamine, polyallylamine, polyvinylamine, polyvinylacetate, polyacrylic acid and polyacrylamide, as well as a copolymer or a graft polymer of a monomere of said polymers and another monomere, contacts with substratum which contains an organic solvent in which moisture content makes 25 vol. % or more and 90 vol. % or less, and contains at least secondary or tertiary hydroxyl group; then, the compound exhibiting anticoagulant activity and contacting with the substratum is exposed to irradiation chosen from a group consisting of β-rays, γ-rays, X-rays, electron beam and neutron beam, and unreacted ingredients are washed off by a nonionic surface-active agent.

EFFECT: invention provides reduced washing off the compound exhibiting anticoagulant activity and hydrophilic polymeric compound.

2 cl, 9 ex, 4 tbl, 3 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel compounds of formula: or its pharmaceutically acceptable salts, where Y represents COOR2; A represents -(CH2)6-, cys-CH2CH=CH-(CH2)3-, where 1 carbon atom can be substituted with O; or A represents -(CH2)m-Ar-(CH2)0-, where Ar represents phenylene or 5-member heteroarylene, which contains one heteroatom selected from O or S, sum of m and o constitutes from 1 to 4, and where one of groups CH2 can be substituted with O; and B represents phenyl, which can be substituted with C1-12 alkyl, hydroxy C1-12 alkyl; R2 represents H, C1-6 alkyl.

EFFECT: obtaining compounds for ophthalmological composition.

15 cl, 1 tbl, 16 dwg, 43 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology and cardiology, and concerns reducing spontaneous erythrocyte aggregation (SEA) in arterial hypertension with impaired glucose tolerance.. That is ensured by the integrated treatment that involves the administration of lisinopril 10 mg once a day in the morning and metformin 500 mg twice a day for 2 months, as well as graduated static and dynamic physical activity, including daily swimming for at least 30 minutes a day.

EFFECT: complex of drug-induced and drug-free modalities ensure reducing the SEA for 2 months that in turn promotes normalised blood rheology and reduced risk of thrombotic complications in the case patients.

2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to gerontology and cardiology and can be used for reduction of pathologically increased biological age (BA) in patients with arterial hypertension (AH) with abdominal obesity (FO) and dyslipidemia. Essence of claimed method lies in the following: to patients administered is complex, that includes hypocaloric diet, calculated in kcal by formula: for women: 18-30 years old - (0.0621 × body weight, kg + 2.0357) × 240; 31-60 years old - (0.0342 × body weight, kg + 3.5377) × 240; over 60 years old - (0.0377 × body weight, kg + 2.7545) × 240; for men: 18-30 years old- (0.0630 × body weight, kg+ 2.8957) × 240; 31-60 years old - (0.0484 × body weight, kg + 3.6534) × 240; over 60 years old - (0.049 × body weight, kg + 2.4587) × 240. Also administered are rationally dosed static and dynamic physical loadings, including morning hygienic gymnastics, preventive medical gymnastics, fractional physical exercises during the day, daily swimming in swimming pool for not less than 60 minutes per day. Also introduced are medications simvastatin 10 mg 1 time before going to bed after meal and lisinopril 10 mg 1 time per day in the morning for not less than 7 weeks.

EFFECT: invention combines application of all components of complex allows to normalise BA within 7 weeks of treatment.

2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to hematology and cardiology and can be applied for reduction of spontaneous aggregation of erythrocytes (SAE) in case of stable stenocardia of I-II functional class (SS I-II FC) and arterial hypertension (AH). Substance of clamed method consists in the following: 2 month-long complex of hypolipodemic diet, dosed static and dynamic physical activities, which include morning hygienic gymnastics, medical-preventive gymnastics, separate physical activities during the day, daily swimming for not less than 30 min. per day in the middle of the day, intake of lisinopril in dose 10 mg 1 time per day in the morning and simvastatine 20 mg 1 time per day after meal.

EFFECT: combined application of all components allows normalising of SAE of patients with SS of I-II functional class and arterial hypertension due to exponentiation of their medical action during 2 months of treatment.

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology, and can be used for normalisation of adenosine diphosphate and adenosine triphosphate thrombocyte secretion activity in the patients with arterial hypertension and impaired glucose tolerance. That is ensured by graduated physical activities, daily swimming in a pool for at least 20 minutes a day, and also prescribed metformin 500 mg twice a day and lisinopril 10 mg once a day in the morning.

EFFECT: combination of therapeutic modalities enables rapid normalisation of adenosine diphosphate and adenosine triphosphate thrombocyte secretion activity that promotes prevention of thrombotic complications in the case patients.

9 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to cardiology, endocrinology, and can be used for normalising the blood α2 antiplasmin concentration in arterial hypertension and impaired glucose tolerance. That is ensured by graduated physical activities, daily swimming in a pool for at least 20 minutes a day, and also prescribed metformin 500 mg twice a day and lisinopril 10 mg once a day at regular hours in the morning. The therapeutic course is 1 months.

EFFECT: offered combination of therapeutic modalities enables normalising the blood α2 antiplasmin level in a relatively short time that promotes prevention of thrombotic complications in the case patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to cardiology, endocrinology, and can be used for normalising the blood plasminogen activator inhibitor concentration in arterial hypertension and impaired glucose tolerance. That is ensured by graduated physical activities, daily swimming in a pool for at least 20 minutes a day, and also prescribed metformin 500 mg twice a day and lisinopril 10 mg once a day in the morning. The therapeutic course is 1 months.

EFFECT: offered combination of therapeutic modalities enables normalising the blood plasminogen activator inhibitor in a relatively short time that promotes prevention thrombotic complications in the case patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to gerontology and cardiology, and concerns biological age reduction in arterial hypertension combined with abdominal obesity. That is ensured by the integrated treatment including a low-calorie diet, reasonable graduated static and dynamic physical activity, daily swimming in a pool for at least 30 minutes, and the introduction of lisinopril in dosage 10 mg once a day in the morning and metformin in dosage 500 mg twice a day for the therapeutic course of 7 weeks.

EFFECT: complex of drug-induced and drug-free therapy combined with empirically prescribed treatment length provides biological age reduction in the case patients estimated by the relation of electronegative cells to total count in a buccal epithelium scrape due to normalised DNA repair and chromosome fragility level.

2 ex

FIELD: medicine.

SUBSTANCE: for treating Hashimoto disease, simvastatin Vazilip 20 mg once a day in the evening and cytoprotector Mexicor 0.1 1 capsule 3 times a day on an empty stomach for 3 months are introduced.

EFFECT: method provides effective treatment ensured by immune corrective action indicated by anti-thyroid peroxidase autoantibodies level decrease that maintains a functional potential of a thyroid gland.

4 ex

Up!