Method to produce milk or milk products with high content of melatonin

FIELD: agriculture.

SUBSTANCE: invention relates to livestock farming. Daily cycle of one or more mammal females is divided into phase of day time with the first light mode with a share of blue light and phase of night time with the second light mode. Animals are milked at least once during night time phase. During night time phase, at least one source of light is used for light mode, which radiates light in the range of wave length of 500 nm or more, and mainly does not radiate light in the range of wave lengths below 500 nm. Produced milk may be processed to make milk products, in particular, dry milk with high content of melatonin.

EFFECT: method makes it possible to produce milk and milk products with high content of melatonin, which may be used as biologically active additives to food or as medicinal agents.

3 dwg, 3 ex, 17 cl

 

The invention relates to a method for producing milk with a high content of melatonin and dairy products, which can be obtained from it.

The main product of the secretion of the epiphysis or pineal gland is indolamine melatonin, opened in 1958 by Lerner (Lerner) and which is formed through the serotonin from the amino acid tryptophan. Melatonin has been studied in subsequent years. Positive effects can be achieved by oral administration of melatonin, so many possible applications have been developed in human medicine and in the field of biologically active additives to food. However, synthetic melatonin pharmaceutical origin should be used for this, because currently, melatonin is not available in sufficient quantities from natural sources.

Melatonin is a derivative of hydrophilic amino acids. In the body it acts as a hormone and an antioxidant. Numerous neurobiological functions of melatonin were currently found in humans, such as, for example, "cure for aging", the trap radicals, the regulator of the circadian clock and the endogenous induction of sleep, as well as the influence on the reproduction, the immune system, the temperature of the body and mental activity. In humans and in mammals the hormone melatonin secret is regulated by the pineal gland. In the process of synthesis of the amino acid tryptophan is decarboxylated and hydroxylases. By educated this way serotonin melatonin is formed by N-acetylation and methylation (=N-acetyl-5-methoxytryptamine).

The use of milk fortified with melatonin, or dairy products made from it, against the progressive reduction in the level of melatonin with age would be the logical decision, for example, from a scientific point of view. Daily melatonin levels in the blood of approximately 20-70 PG/ml for young people (20-30 years). It is at night increases to approximately 125 PG/ml This level concentrations would be reached after consumption of milk or milk powder. When oral administration of melatonin, however, is subjected to relatively high presystemic impact, i.e. approximately 30% metabolized by the liver and secreted, and therefore not provided in an effective amount in the blood. Therefore, you should take approximately 30% greater number of oral to achieve the desired predetermined concentration.

Melatonin from natural sources currently available only with reservations. Previously very small concentrations were detected in some plant species. However, there is no systematic way of allocating and no natural storage when stored for the I products, rich in melatonin. The study and research of medical effectiveness and bioavailability of melatonin derived from natural raw materials, not currently published. The degree to which melatonin extracted from natural raw materials, different from the pharmaceutically received melatonin in relation to biological action and availability of currently poorly understood.

It is known that melatonin is found in trace quantities in the blood plasma of humans and mammals and continuously reproduced. Melatonin is associated with blood plasma, however, is not suitable for use in medical products for humans or as a food product or biologically active food supplements.

In comparison, a well-known food product obtained by using the blood of various mammals, namely milk, suitable for the extraction of natural melatonin. Here melatonin, in particular, is associated with milk protein.

It is known that people change light radiation, it is important to regulate the behaviour with time of day and seasons. Cycles of light/dark regulate many patterns of human behavior, including winter depression, the cycles of sleep/Wake, body temperature, mental activity, subjective consciousness and action. This effect, known on the I people, also largely applicable to mammals.

All animals adapt to the cyclical change of day and night. The so-called internal clock regulate all vital functions such as metabolism, body temperature, hormonal and immune systems, as well as behavior in the diurnal cycle. 24-hour cycle of this internal pacemaker not regulated by the external time information.

This so-called circadian system also operates in the absence of external factors, but does not match exactly one day. The expression "circadian" comes from the Latin words "circa" (about) and dies (day).

Synchronization internal pacemaker with the external day/night cycle occurs through temporary generators, external stimuli that tell the body information about the time of day. The most important temporary generator for mammals is light. But also factors such as temperature, activity and social interaction can shift the circadian cycle. There are many indicators that the circadian system of mammals can be synchronized light exclusively through the retina, where information about light conditions, being perceived through the retinal photoreceptors.

Normal agricultural methods currently used for lactating mammals, p is swalat animals to move freely, and they are free to lie down on his Mat, to make provisions for meals and milking both in the daytime and at night. Areas for livestock are usually equipped with emergency fluorescent lamps at night, so that animals can distinguish friend from foe and can search for them. Conventional lighting systems of this type reduce melatonin production at night.

In patent WO 01/01784 described method of production of milk, rich in melatonin, which is the daily cycle of mammals is divided into one light and one dark period, and the animals milked in the end of the dark phase. The amount of light during the dark period is preferably below 40 Lux. Also in the patent GB-A-2387099 described method of preparation of milk, rich in melatonin, which the daily cycle of mammals is divided into one light and one dark period, where the intensity of light in the dark period should not exceed 50 Lux. Also described experiments on the shading and the use of invisible light in the dark period.

Previously known methods have a common feature, namely that the animals in the "dark phase" at least, as far as possible, the amount of light is required. This, however, is difficult, because animals can navigate only with great difficulty or not at all m the gut to navigate during this dark phase due to the lack or inadequacy of light, not use, in particular, during the milking process. The content of melatonin in milk thus is a negative effect.

In particular, if animals are shed in large numbers, the lack of orientation is a serious problem. So the above methods best suited to small farms. For larger herds of animals in systems with free grazing these methods are hardly applicable, according to the state of things in this area. Industrial production of direct relevance to the market, therefore, hardly possible.

Therefore, the aim of the invention under examination is to develop a method of production of milk with a high content of melatonin, which facilitates adequate orientation animals, as well as working staff at night and which is also suitable for high number of animals.

These goals, surprisingly, it was possible to carry out using the method of preparation of the milk with a high content of melatonin or dairy products, the way in which the daily cycle of one or more female mammals is divided into a phase of daylight saving time, with the first mode of lighting with a partial contribution of blue light and the phase of the night time with the second mode of illumination, and in which the animal or animals being milked, at measures which, once during the night-time phase in order to obtain milk with a high content of melatonin, which is characterized by the fact that during the phase of night time light mode is used, at least one light source that emits light with a wavelength region of 500 nm or more and, in fact, not emits light with a wavelength below 500 nm. The light source, in particular, emits light yellow, orange, amber or red, or a mixture of these colors, where red light is particularly preferred.

In the invention presented here describes the way in which when using the appropriate light regimes affecting the circadian cycle and suppression of melatonin in animals so that they get milk with a high content of melatonin. To achieve this animal, in spite of this, contain in the phase of night time light mode, which provides adequate orientation. Thus, the method can also be applied in case of large number of animals.

Figure 1 shows the averaged curve according to the circadian response to the wavelength of light. Figure 2 compares the dependence of the photopic, scotophase and circadian effects on wavelength. Photopic refers to vision under normal lighting conditions. Scotophase refers to vision in dim light is in the dark. Figure 3 shows the spectral distribution of the red LED (light emitting diode).

For the production of milk protein, enriched melatonin, all lactating animals are suitable, in particular female animal selected from a mammal breeds of sheep, cows and goats. Due to its physiological prerequisites for these three species possess an ideal economic value of body weight and milk yield. They have similar circadian cycles and systems and natural drives of milk (udder). In addition, they are widely distributed populations all over the world with good availability.

One or more animals are kept in conditions daily cycle according to the invention, preferably at least 10, more preferably at least 50 or 100 or even more than 200 animals. Preferably, the group of lactating animals subjected to cycle according to the invention. The contents of the entire group in terms of the daily cycle according to the invention has the advantage, because then you do not need any special intervention, the animals do not experience any unusual changes, and separation at various livestock farms can be avoided.

Unless States otherwise, here light means the visible radiation incident on the eye, which causes a visual sensation, i.e. the radiation length is olny in the range 380-780 nm. The light intensity is usually defined as the amount of light falling on a small area and not as the amount of light that falls on the retina. The latter, however, is crucial for circadian effects of light. Not the intensity of the light from the light source in the suites, and the color of light and the wavelength of the colored light is important for the desired effect on the circadian system, which is important for the production of melatonin.

Accordingly, as light sources are only those that emit light in the visible range. The spectral distribution of the light received from the light sources, find out using the emission spectra, in which the intensity is given depending on the wavelength. Often given the relative intensity at which the highest value in the given range equal to 100%.

The amount of light, its spectral composition, spatial distribution and time, and duration that are required to view mammals differ significantly from the requirements of circadian functions.

Among other things, the invention is based on the dependence of the suppression of melatonin from the spectral composition of the used light source. By means of the invention is optimally adapted lighting artificial light can be achieved for Maxim is inogo output of melatonin. This colour parameters of different light sources were investigated in relation to their effectiveness in the suppression of melatonin.

Light is the primary stimulator of regulation of the education of melatonin. The use of selected light sources for specific effects on circadian function gives a controlled suppression or stimulation of the secretion of melatonin by the pineal gland, due to different light regimes and, consequently, leads to an increase in the concentration of melatonin in plasma. The content of melatonin in plasma correlates somewhat ambiguously and with swig in time with the concentration of melatonin in milk.

This is a new type and combination of light sources and their color, because the number of light sources, the spectrum of colors of light and their wavelengths, the spatial distribution and the time and duration of application of light for circadian effects on animals are completely different from those that are important for normal vision. It was found that to influence melatonin levels in the blood of mammals there is light, which is good, and there is a light that is inappropriate. Lighting systems, which have been found suitable for careful control photopic and circadian effects of light for supres the AI melatonin.

Adaptation of physiological and psychological processes of the organism to the temporal environment occurs through the internal clock. When the off time generator internal clock runs freely. For example, in complete darkness flowing freely circadian period of human lasts, on average, 10-20 min longer than the 24 hour day. Disturbance in the synchronization of the internal clock and irregular diurnal cycle, which is their result, high-performance in a negative sense in the production of melatonin. Adaptation of circadian circadian period to the current day/night cycle occurs via adsorption is carried light by the retina and through the mechanism of suppression of melatonin.

Not the light intensity of the light source, measured in Lux, is crucial for the suppression of melatonin, but rather spectral dependence. It was found that, in contrast to the curve of the luminance sensitivity to light for daylight vision, the spectral sensitivity of the circadian photoreceptors can be affected primarily by short-wave region of the visible spectrum. This leads, for example, the efficiency of the blue light for the regulation of the circadian system than other spectral colors.

Therefore, from the point of view of the best possible efciency is melatonin, spectral sensitivity, i.e. the dependence of the efficiency on wavelength, is of great importance. Here, you need to make a distinction between photopic or scotophase effect of light and circadian effects of light, i.e. the impact on melatonin production.

Figure 1 shows the averaged curve according to the circadian response to the wavelength of light. Figure 2 shows curves of sensitivity as a function of wavelength for photopic, scotophase and circadian effects.

Photopic and circadian luminous efficiency vary significantly depending on the type of the selected light source. The measurement of luminous efficiency in Lux or lumens per watt is therefore not appropriate to assess the suppression of melatonin. The maximum efficiency of suppression of melatonin is achieved when the wavelength of light from about 450 to 470 nm. These wavelengths are in the range of spectral colors of sunlight and artificial light blue color. Photopic and circadian effects of different sources is illustrated by the examples in the following table.

The light sourceLuminous efficiency (photopic) (LM/W)Luminous efficiency (circadian) (LM/W)3000 To
fluorescent rare-earth
87 (1,00)149 (1,00)1,00
4100
fluorescent rare-earth
87 (1,00)275 (1,85)1,85
7500
fluorescent rare-earth
65 (0.75 in)285 (1,91)2,56
Sulfur, scandium, discharge108 (1,24)300 (2,02)1,63
Sulfur, high pressure127 (1,46)115(0,07)0,53
The red LED (630 nm)44 (0,51)2 (0,02)0,03
LED yellow (590 nm)36 (0,41)10 (0,07)0,17
LED green (520 nm)25 (0,29)88 (0,59)to 2.06
The blue LED (460 nm)11 (0,13)681 (4,59)36,2
The white LED (460 nm + fluorescent)18 (0,21)90 (0,60)2,91
Daylight (6500 K)--2,78

Photopic luminous efficiency specified for fluorescent lamp 3000 K (Kelvin), is 44 for the LED in the spectral range of the red color, but 11 for LED range blue. Circadian light efficiency specified for fluorescent lamp 3000 K is 2 for the LED in the range of the red color, but 681 for LED range blue.

For the content of melatonin is important only that the colored light sources with a maximum luminous efficiency in the short wavelength range maximize the circadian effect, and colored light sources in the wavelength range minimize it. For example, a blue LED (peak at about 460 nm) and red LED (peak at about 630 nm) have approximately the same photopic light intensity. Circadian light efficiency of these two colors differ, however, about the ratio of 1200:1.

The relative activities against the Noah circadian to the photopic luminous efficiency, specified for fluorescent lamp 3000 K with red LED, achieves the best possible efficiency to stimulate the formation of melatonin. Smaller, but adequate effect obtained with the amber LED, orange or yellow color or mixture of colors this part of the spectrum or by using sodium discharge lamp with yellow color.

The phase of daylight is the phase of maximum suppression of melatonin is controlled by the specific application of light, preferably using during the day natural light daytime, while the night-time phase is the phase of maximum inhibition suppression of melatonin is controlled by the specific application of light, preferably using natural night darkness.

Accordingly, the daily cycle of animals is divided into a phase of daylight saving time, with one light regime and the phase of the night time with a different light regime. In particular, the light mode phase day time includes light regime than blue light. In the phase of night time in your light, in essence, do not reveal the proportion of blue light.

With regard to the intensity and time of application, the light modes according to the invention can basically be controlled as required. The corresponding phase can be reduced, the volume or shifted forward or backward, as you need. However, circadian cycles can be changed very slowly, because the circadian system is very inert. Therefore, you can practice changing daily cycle slowly, i.e. in a number of stages until the desired daily cycle and/or to start a real milk with a high content of melatonin only after the exploration stage, i.e. after a few days.

Regardless of the fact that the application of light can be controlled by time, as required, shall prevail, if the phase of the day time continues, for example, approximately 8-22 hours, in fact, approximately 12-21 hours and, preferably, about 14-20 hours. Favorable duration is, for example, approximately 17 hours plus/minus 1 hour or more. The night-time phase may, for example, continue for about 2-16 hours, really, about 3-12 hours and preferably about 4-10 hours. Particularly favorable duration is, for example, approximately 6 hours plus/minus 1 hour or less.

The phase of daylight saving time, there is a phase of suppressing the formation of melatonin, whereas in the phase of night-time suppression inhibited. In order to use daily light and dark phases, phase, day time and night time should be aligned to fit the Wii with them. This, however, is not fundamentally necessary, but is effective from the point of view of practical consideration. Phase day time (phase suppression) could, for example, be organized in the period from approximately 5.00 hours to 22.00 hours, and the night-time phase (inhibition phase suppression) in the period from approximately 22.00 hours to about 5.00 an hour. Of course, the phase can also be arranged at other time intervals.

The transition from one phase to another phase should in each case, it is preferable to simulate the transition from light to dark, which simulate natural light transition from night to day and Vice versa. Any violation of normal cycles affects the secretion of melatonin. A transition of this type may, for example, take approximately 30 minutes to 1.5 hours, preferably about 1 hour. The transition time can be added in half to the phase of the daytime and night-time phase.

Each phase of the daytime and night-time phase are characterized by different light regimes. Both light mode can be provided with the aid of artificial light; in the phase of daytime use normal sunlight.

In the phase of daytime animals, in particular, are exposed to light mode with a fraction of the blue light, which gives a high photopic and circadin the th effects. Blue light is light, the wavelength of which lies in the range from about 440 to 490 nm. Maximum suppression of melatonin can be achieved when the animals sunlight or by using light sources with high circadian effect. According to the invention are preferred lamp full spectrum (approximately 375-725 nm), which is most similar to sunlight (approximately 290-770 nm) and include important UV light, as well as the known range of the colors of the rainbow. Radiation that simulates sunlight for several hours also causes the maximum suppression of melatonin by strong effects on the circadian system.

Lamp full spectrum commercially available. Examples are lamp with a light color 940 (white) from Osram or from Osram Biolux with a light colour 965. The latter is preferred, because it roughly simulates the solar spectrum. These lamps also offer a full range of other manufacturers.

In addition to sunlight and lamps are full spectrum, can also be used with other light sources, which inhibit production of melatonin by significant circadian action. The use of blue light (wavelength of approximately 460 nm) would be, for example, possible, or other sources of light than blue light, with which d is attained in a strong suppression of melatonin. When using blue light of the risk of thermal harmful effects on the retina, which depends on wavelength, it is necessary to take into account.

Light mode with artificial lighting, such as lamps, full spectrum, phase of daylight saving time may also be increased or reduced as required. The ability of lactating animals give milk increases significantly when uvelichenie light phase.

In the phase of night-time animals are exposed to light mode, which inhibits the suppression of melatonin and therefore causes the formation of melatonin. The maximum inhibition of suppression of melatonin would in principle be achieved in the natural darkness (no light). However, this has the disadvantage that the orientation becomes impossible. First of all, it is impossible during the milking process. In addition, disorientation causes stress in animals, especially when they are in large quantities and in a limited space. This also affects the formation of melatonin.

The lamp of the invisible light are UV lamps (approximately 345-400 nm)that affect the circadian system only slightly, but due to their low photopic luminous efficiency is not suitable for night-time phase, in particular, in systems with free grazing, because no adequate the Oh orientation cannot be achieved due to low light intensity. As UV light, the lamp of the invisible light can also emit visible light in the blue range.

It was surprisingly discovered that these disadvantages can be overcome if to neutralize the darkness, apply light sources that emit light in the wavelength range of 500 nm or more, and in the wavelength range below 500 nm, essentially, does not emit any light, so the light source, in particular, emits light yellow, orange, amber or red, or a mixture of these colors. Therefore, in the wavelength range of visible light from the light source gives the spectrum of the emission, in which the highest value with a relative intensity of 100% is at a wavelength of 500 nm or more.

What light source, essentially no light is emitted with a wavelength below 500 nm, means, in particular, that in the spectrum of emission of visible light below 500 nm any measurable peak, if present at all, gives a relative intensity of less than 15%, preferably less than 10% and especially preferably less than 5 or less than 3%. Preferably used in the light source does not emit essentially, the range of light wavelengths below 520 nm and preferably below 540 nm. Particularly preferably used in the light source does not emit light in the wavelength range below 500 nm and, in particular, below 520 nm and, most of the E. preferably, below 530 nm.

As light sources can be used a normal lamp, such as, for example, thermal emitters, continuous heaters, line heaters and gas-discharge lamps that contain the monochromator, so that, essentially, does not emit light with a wavelength below 500 nm. Examples of monochromators are prisms, diffraction gratings and optical filters. As filters, for example, suitable interference filters, bandpass filters or long filters that block the shortwave region. Filters of this type, for example, available from Schott. Red light bulbs can be made this way. Red light bulbs with adequate blocking blue light component can be used in the invention.

Light sources of this type that work with filters or other monochromators, also have some drawbacks. One aspect is that the wavelengths are not completely cut out, but rather weaken. Also, defects in the barrier lead to small peaks at different wavelengths or harmonic oscillations in the transition region, so that a small amount of light may also be present in the range below 500 nm. Thus, red light bulbs are not pure red color, but rather they can that is to contain small proportions of other spectral colors. In addition, a portion of the received light not used for illumination, but instead sucked. This increases the energy consumption.

Therefore, preferred are those light sources that do not require any of the monochromator. Accordingly, preferably, do not apply heat emitters. Preferably the light source is applied luminescent emitters. Fluorescent emitters can be so-called linear monochromatic emitters or emitters. Examples of fluorescent emitters are gas-discharge lamps and light emitting diodes.

Therefore, as a light source is preferably used fluorescent emitter, which basically doesn't emit light with wavelengths below 500 nm, or not emit light with wavelengths below 500 nm.

The spectrum of emission of the light source in the wavelength range of visible light has a maximum, preferably at least above 550 nm, preferably at least above 570 nm and, more preferably, above 600 nm. The light source preferably has a maximum below 550 nm, more preferably below 570 nm and even more preferably below 600 nm in the visible wavelength range with a relative intensity of more than 5%.

It was found that in the phase of the night time, it is important to apply by the group in which light with wavelengths less than 500 nm, better less than 520 nm and, even better, less than 550 nm, minimized, and preferably almost completely, or completely absent. This is possible with light sources that give a continuous spectrum when using a suitable filter. Fluorescent emitters, such as LEDs, Gly (SVL), however, are preferred, because in comparison with thermal radiators, they emit narrowband spectrum and do not require filtering. Using the method according to the invention can be achieved by improving the orientation of animals due to the much higher photopic the effect of the used light sources, in particular fluorescent emitters.

A suitable light source is, for example, sodium discharge lamp (NGL). Ngly are gas-discharge lamps that are characterized by high photopic luminous efficiency and emit monochromatic yellow light with a wavelength of approximately 589-590 nm. Illumination NGL suitable for reliable recognition of targets and obstacles. Yellow light should also be less attractive to insects.

In particular, suitable fluorescent emitters are light-emitting diodes, known as LEDs. LEDs are very efficient light source, the kami of the world. They usually give a relatively narrow-band signal with a maximum in the emission spectrum, as shown, for example, in figure 3. Using LED lamps can be installed in a specific desired wavelength range, and they also have an adequately large photopic effect, so that the animals can easily navigate when illuminated by these light sources.

As light sources for night-time phase of the selected ones of the light sources that have a circadian low luminous efficiency. The primary factor is choosing the right light colors. Blue LEDs or LEDs white light are not suitable due to the proportion of blue light. Perfect light colors are red, less good, but also possible are amber (also "supergravy") (i.e. a maximum of about 612 nm), orange (i.e. a maximum of approximately 605 nm) or yellow (or a maximum of approximately 585 nm), as well as the mix of colours in this part of the spectrum. Yellow light can also be obtained using NGL. Red light-emitting diodes are preferred (i.e., the peak at about 630 nm; including "invisible" with a maximum of approximately 660 nm), which have photopic luminous efficiency, which is very high, despite the minimal circadian effect, and which are therefore ideal for functioning Nochnoe time. In addition, LEDs are the only lamps that give red light pure color. LEDs of this type are widely commercially available.

Examples of commercially available and applicable for the invention of the LEDs are, for example, Lumileds® red Luxeon 1 watt, Lumileds® Luxeon Star/O red 1 watt or SOUL R32 red 1 watt.

There is no need to apply the light source during all phases of the night time. However it is used, in particular, at least during the milking process, because at this time the necessity of orientation among the animals and the staff is the greatest. Preferably, the light source used for at least one-third or at least half of the duration of the phases of the night time. Since the light source used primarily fluorescent lamp, has virtually no negative impact on the education of melatonin, and improvement orientation for animals and the existing staff is also possible light sources, in particular, preferably used for almost all the night-time phase or all phases of a night time. The light source, in particular an LED lamp, used during the night phase time in norm at least 1 hour, preferably at least 2 hours, more preferably at least 5 hours, and more preferably, is about the least 6 hours.

Otherwise, other light sources should not be used in the night-time phase. However, in total darkness is not necessary. In combination with the source or sources of light for night-time phase natural the darkness of the night is quite possible. In particular, practically is not present illumination light with the content of the blue component (in particular from 450 to 470 nm).

It should be noted that the natural system include such a way that the possible short-term disturbances in the system (storms, lack of light etc) and change (adaptation to the seasons by substitution phases of day and night time), and the method of the invention activates them.

To implement light regimes phases daytime and night time light sources should preferably be set as the height and with such frequency that the light might be made manifest in all areas accessible to animals. When using sunlight area available to animals, should be selected, of course, appropriately.

Definition of luminous efficiency suites with the aim of inhibition or stimulation suppression of melatonin is associated with the production of melatonin, because the properties of the used light should be considered in respect of the relevant aspects for the circadian system, and televisually system. Not the intensity of the light source in the suites, and the color of the light and the wavelengths of light colors are decisive for the desired effect on the circadian system, which is important for the production of melatonin.

Surprisingly, the space surrounding the animals may even be relatively brightly lit in the night-time phase by using light sources used according to the invention, moreover, the absence of this leads to a significant decrease in the concentration of melatonin in milk. This contradicts the previous statement in this area, according to which, as far as possible darker ambient conditions deem it necessary. The decisive advantage is that the orientation is substantially lighter, and lights can be turned on without much trouble during the deep phase of the night time.

Light intensity obtained by the use of light sources in the night-time phase may preferably be more than 50 Lux, preferably more than 100 Lux and, particularly preferably, more than 250 Lux. Light intensity may be, for example, 500 Lux or more. Light intensity can be measured using normal light measuring devices. For line sources, such as LEDs, for more precise measurements can be used spectara eometry. The light intensity is considered in relation to the radiation falling on the animal's eyes. Thus, a specific light intensity measured at the height of the eyes of animals. In this way a specific light intensity for cows measured at the level of approximately 1.50 m from the ground, and goats at the level of approximately 50 cm from the ground.

With regard to light intensity, it is necessary, however, to consider that the long-wavelength light, such as defined here, also gives a circadian effect, even if it is extremely low, which increases with decreasing wavelength. At high light intensity, this circadian effect can influence the content of melatonin. Therefore, when the light intensity more than 50 Lux, in particular, it is preferable to use a light source which emits light with a wavelength maximum above 620 nm, such as a red LED.

Relevant animal being milked at least once in the night-time phase. Depending on the number of animals to be milked, the beginning of the milking process set so that it was completed before the end of the night phase of time. The milking process to really begin, for example, approximately in the middle of the night-time phase, in particular when you want to milk a large number of animals, in order to have the opportunity to milk all the animals in the phases of the night time. The milk obtained in this way has a high content of melatonin. The hormone melatonin is converted in the liver mainly in the 6-sulfatoxymelatonin and is removed through the kidneys. The half-life is less than approximately 60 minutes. To maintain the level of melatonin in milk inhibition suppression of melatonin should be maintained until the end of the milking of the animal, i.e. the milking process takes place in the phase of the night when illuminated by the light source.

The harder and longer it takes to suppression, the higher the maximum melatonin obtained then in milk. Therefore, by reducing the phase of night-time light mode with the lowest possible circadian effects and milking at the end of the night-time phase can be obtained milk with a high concentration of melatonin. For example, the increase in phase day time up to 16 hours and preferably more than 18 hours, suitable for obtaining high peak of melatonin in the night-time phase. The light phase of the day time can then start immediately after milking.

Animals, of course, can be milked more than once a day and as needed, i.e. twice or more often. Preferably, the milking is also carried out at least once during the phase of daylight saving time. Because this milk shows no increased content of melato the ina, it is also used separately from the milk with a high content of melatonin, typed in the night-time phase.

Milk, collected during phase night time, preferably rapidly cooled below 10°C., for example up to 3 or 8°C. Here quickly means, for example, within two hours or less. Milk can be processed in the normal way with the formation of all known dairy products, get milk products with a high content of melatonin. Dairy products derived from milk, such as milk powder, and methods of production are well known. General description can be found, for example, in Ullmanns Encyklopadie der technischen Chemie [Ullmann''s Encyclopedia of Industrial Chemistry], 4th edition, volume 16, p.689 ff. Examples of dairy products are milk, cheese, yoghurt, quark, cottage cheese and whey products. Preferably, the milk is turned into milk powder with high content of melatonin by drying. Well-known methods can be used for this purpose. The hormone melatonin is associated with protein in milk and is not destroyed during processing pressure, heat, or freezing.

Milk or dairy products, particularly milk powder, can be used for normal use, in particular, the quality of food products, biologically active additives to food, Lekarstvo what x means. In the process of further processing of milk by fat splitting or separation of lactose relative share of melatonin in the final product (e.g. milk powder full fat milk or skim milk) can be enhanced further.

Normal day milk contains melatonin in the amount of about 1.5 to 3 PG/ml Milk obtained according to the method according to the invention usually contains at least double the amount or even up to ten times the amount or more melatonin. The content of melatonin in it may, for example, to reach more than 10 PG/ml, i.e. 15-50 PG/ml Milk, enriched with melatonin, which is obtained according to the method according to the invention, can be treated so that the concentration of the hormone melatonin, which is associated with molecules of milk protein in the final product will be significantly increased (excess up to 350-fold) compared with normal concentration of melatonin present in milk.

Milk powder can be obtained, for example, the concentration of melatonin above 100 PG/g, preferably above 150 PG/g and, more preferably, more than 200 PG/g Concentration of melatonin may, for example, up to 1000 PG/g, if required. Available-for-sale the final product in the form of powdered milk obtained according to the invention contains, for example, concentration is the s melatonin approximately 200-500 PG/ranging increasing concentration in this way numerous possible applications in the medical field and as food or biologically active additives to food are feasible. Milk powder can, for example, be obtained with compatible carriers or without them, for example in the form of powder, capsules, solution or tablets. It can be mixed with other suitable additives and/or active ingredients such as nutrients, such as vitamins, or trace elements, or pharmaceutically active ingredients.

The method according to the invention is suitable for stable industrial production of natural melatonin, especially for the production operation more than 200 animals. Natural melatonin is here associated with milk protein. Thus, natural melatonin associated with milk protein, can be obtained in large quantities and in a simple way, preferably in the form of milk powder.

Goals that can be achieved using the method according to the invention include the following.

1. The natural circadian cycle of animals maintained, and daily temporal information is transmitted to the body.

2. By setting and regulation of the light sources used according to the invention in premises where animals, the production of the hormone melatonin in the serum and, therefore, also in milk stimulate such a way that the concentration of melatonin in milk many times higher than normal concentration. The average herd in ucaut melatonin levels in the final product above 200 PG per g of dry milk, upon reaching the individual animal level above 500 PG/g

3. By the specified time of application of the above-mentioned light sources specially manipulated diurnal phases of light and darkness so that the secretion of melatonin by the pineal gland maximally suppress or maximally stimulate such a way that within a precisely defined period of the day will receive the highest possible concentration of melatonin in milk, and by milking animals at exactly the time they get the milk concentration of melatonin increased many times.

4. In premises where animals are, you can still do normal emergency lighting using white light (for example, incandescent lamps, neon or fluorescent lamps).

5. Darken the room in which animals placed in order to avoid exposure to light, is not required, because the natural darkness of the night and using the aforementioned light sources adequately inhibit the suppression of melatonin.

Examples

Impact on dairy cows of different light sources was studied taking into account the achievements of the content of melatonin. The study took place in a large herd, where varied photoperiods phase of daytime and night-time phase (Examples 1-3). During the night phase of time randomly selected dairy cows milked,and determined the content of melatonin in milk.

The selected light regime and the average content of melatonin, found in milk, are summarized in the following table.

Example 1Example 2Example 3 (Comparison)
Light regime, phase daylight timeArtificial daylight white light, 16 hNatural lightingNatural lighting
Light regime, the phase of the night timeOnly the light from the red light-emitting diodes**Only the light from the red light-emitting diodes**White emergency lighting
Melatonin*20,35of 10.254,57
*The average content of melatonin in human milk (PG/ml); **wavelength 600-640 nm

Immediately you can see that clearly the increase in the concentration of melatonin can be achieved using the method according to the invention. Details concerning the schedule of milking in these examples, below.

27,49 363
Example 1
Sample numberThe animal numberThe morning milkingMelatonin PG/ml
120505:009,95
239205:0033,40
330505:10of 10.72
431205:1031,11
530305:1010,71
625205:1013,69
737505:2032,98
827705:2532,49
929805:25
1023305:3017,79
1129905:3532,03
1238605:40of 11.15
1324105:4514,53
1428605:5011,68
1525005:5024,18
1632205:5026,77
1723405:5016,44
1831905:5033,48
1925704:5013,16
20237 04:5022,26
2125504:4024,12
2233104:5010,97
2331504:5014,40
2435604:50to 11.79
2540304:5532,08
2628004:55to 10.62
2725404:5511,35
2821205:509,73
2927605:3032,14
3034406:1011,80
31 30906:1034,11
3231605:1022,14
Average20,35
Example 2
Sample numberThe animal numberThe morning milkingMelatonin PG/ml
11705:003,30
220505:0017,79
331405:10of 5.53
430305:10to 11.79
525605:104,15
3405:10for 9.47
738605:2016,44
825405:2514,53
928605:2511,68
1035605:3010,71
1125705:3513,16
1236605:407,35
1331505:459,95
1437005:508,56
1524105:50of 11.15
1623405:50 11,35
1723305:50to 10.62
1823705:5022,26
1933004:509.28 are
2025004:50of 10.72
2132204:4010,97
2227004:506,44
2331204:509,73
2422704:509,27
2540304:5513,69
2634004:553,40
27313 04:55of 8.06
2836505:502,70
2939205:3014,40
3031906:1011,18
3134406:108,31
3230906:2010,12
Average20,35
Example 3 (Comparison)
Sample numberThe animal numberThe morning milkingMelatonin PG/ml
13863.10-4.10of 8.06
23753.10-4.105,63
33.10-4,10of 5.06
43703.10-4.107,18
52653.10-4.10to 3.58
6343.10-4.103,51
73013.10-4.104,35
83833.10-4.103,90
93143.10-4.103,60
10173.10-4.101,91
112503.10-4.10for 9.47
122473.10-4.105,72
133053.10-4.105,88
142863.10-4.104,40
152053.10-4.106,41
163823.10-4.108,24
173223.10-4.103,98
183923.10-4.105,24
193303.10-4,106,60
201423.10-4.101,47
213033.10-4.102,40
222413.10-4.101,52
232963.10-4.10a 4.9
24340 3.10-4.103,50
254053.10-4.107,10
263163.10-4.100,36
273453.10-4.104,65
284113.10-4.104,94
293443.10-4.103,74
303653.10-4.103,21
313093.10-4.103,48
323193.10-4.102,31
Average4,57

1. Method for the production of milk with a high content of melatonin or dairy products, which is the exact cycle of one or more female mammals is divided into a phase of daylight saving time, with the first light regime with a portion of the blue light and the phase of the night time with the second lighting mode, and the animal or animals being milked at least once during the night-time phase in order to obtain milk with a high content of melatonin, which is characterized by the fact that during the night-time phase, at least one light source is used for the light mode, which emits light in the wavelength range of 500 nm or more and generally do not emit light in the wavelength range below 500 nm.

2. The method according to claim 1, characterized in that the light source provides at least the maximum of above 550 nm in the wavelength range of visible light during the night-time phase.

3. The method according to claim 1 or 2, characterized in that the light source used for phase-night time is the fluorescent emitter.

4. The method according to claim 1, characterized in that the light source used for phase-night time is a LED lamp or high-pressure sodium discharge lamp.

5. The method according to claim 4, characterized in that the LED lamp emits red, yellow, orange or amber colored light or light color mixtures thereof, where the red LED lamp is particularly preferred.

6. The method according to claim 1, characterized in that the animal is a sheep, a goat or a cow.

7. The method according to claim 1, characterized in that the group of lactating animals kept in terms of this daily cycle.

8. The method according to claim 1, x is rasterizes fact, that milking animal during a 24-hour day, at least twice.

9. The method according to claim 1, characterized in that the light source used in the phase of the night time, at least during the milking process.

10. The method according to claim 1, characterized in that the light source during the phase of night time use, at least for two hours, and, preferably, throughout almost all phases of the night time.

11. The method according to claim 1, characterized in that the light regime in the phase of daylight saving time, use one or more lamps full spectrum sunlight or other light sources with high circadian effect.

12. The method according to claim 1, characterized in that the phase of the daytime lasts longer than 14 hours

13. The method according to claim 1, characterized in that the further from the obtained milk is extracted with lactose and/or provide the breakdown of fat in milk.

14. The method according to claim 1, characterized in that the light source used in the phase of night time, gives a light intensity of more than 50 Lux, preferably more than 100 Lux.

15. The method according to claim 1, characterized in that the milk is enriched with melatonin-treated with the formation of powdered milk.

16. Milk powder with a concentration of melatonin more than 150 PG/g, obtained by drying the milk produced by the method according to claim 1.

17. Prima is giving milk or dairy products according to any one of claims 1 to 15 or dry milk P16 in the quality of the product, biologically active food supplements or medicines.



 

Same patents:

Infant food // 2404785

FIELD: food industry.

SUBSTANCE: invention relates to food and pharmaceutical industry. Infant food composition, containing protein, fats, carbohydrates, nucleotides, nucleosides and nonprotein negatively charged polygalacturonic acid taken at in certain amounts. Application of composition for production of composition for infant feeding. Application of nutrient composition to produce composition for treatment and/or prophylactics of inflammatory disease, diarrhea, eczema and/or atopic dermatitis of a baby.

EFFECT: nutrient composition efficiently imitates protective action of human milk, in particular, against allergies and infections.

9 cl, 4 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine and may be used to reduce human biological age. For this purpose preparation "Transfer-factor" is introduced to patient in dose of 1-3 capsules per day for 60-80 kg during 6 weeks.

EFFECT: reduced age-related changes in practically healthy people by recovery of potential of cellular growth of tissues.

1 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine and can be used for manufacturing product for treatment or prevention of benign hypertrophy of prostate and/or erectile dysfunction in mammals. Product is obtained by fermentation of food material, which contains animal milk, in presence of at least one strain of Lactobacilli. Obtained milk serum is used for treatment or prevention of said pathology.

EFFECT: application of said product also ensures blockade of α1A-adrenoreceptors, which, in turn, results in reduction of tone of prostate unstriped muscles and bladder outlet.

31 cl, 2 dwg, 8 tbl, 10 ex

FIELD: medicine.

SUBSTANCE: invention relates to experimental medicine and deals with restoration of reducing with age potential of cell growth of tissues in old laboratory animals. For this purpose medication "Transfer-factor" is introduced to laboratory animals in dose corresponding to 1 capsule a day per 50 kg of weight.

EFFECT: method ensures activation of T-lymphocyte function and restoration of potential of cell growth of salivary gland tissues in said group of animals.

FIELD: medicine.

SUBSTANCE: invention is a skin moistening agent for oral delivery comprising fermented milk whey as active component and obtained by milk fermentation using the strain Lactobacillus, helveticus, CM-4 (deposited with International depositary institution for patents by National Institute of advanced science and technology under inventory number FERM BP-6060).

EFFECT: invention provides skin moistening.

6 cl, 2 ex, 5 tbl

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to gynecology, and concerns remedy for treating bacterial vaginosis, which contains fermented mare's milk of 2-3 day ageing with proteinase activity 475.5 units, obtained using microorganism Lactobacterium bulgaricum and yeasts of genus Torula, and includes lactic acid, ascorbic acid, panthotenic acid, riboflavin, thiamine, vitamin B 12. Course of treatment is 10 days.

EFFECT: invention ensures fast vagina sanation and recovery of its normal microflora.

2 cl, 1 ex, 2 dwg

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to pediatrics, and concerns prevention of acute respiratory viral infections in pre-school children. For this purpose on the background of vitamin therapy child is prescribed 150 ml of cultured milk product of clinical preventive nutrition bifilact "Biota", mixed with 30 ml of fermenting regenerated live biomass Enterogs with 3-4 weeks course.

EFFECT: said treatment scheme ensures increase of child organism resistance due to efficient correction of intestine disbios by increased concentration of bifidum- and lacto- bacteria with minimal load on fermentative system of gastrointestinal tract.

2 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: mare's milk concentrate which has been dried up at temperature from 10 to 50°C at pressure from 1 to 50 mb, on biologically inert, highly dispersive matrix being a highly dispersive dioxide of silicon, apply for obtaining of a preparation for oral ingestion at treatment of diseases of neurodermite and psoriasis. The preparation additionally contains irreplaceable amino acids, hydrocarbonate, potassium, carbonate, citrate, calcium, magnesium, vitamin C, vitamin E, niacin, zinc, iron, beta carotin, pantothenic acid, manganese, vitamin B6, B2, B1, B12, copper, sodium, a biotin, Acidum folicum, molybdenum, selenium, xanthan, fructose, lemon acid, or from both such substances.

EFFECT: application of mare's milk concentrate is oral for neurodermite and psoriasis treatment, firmness at storage and maintenance of high-quality components in the concentrated form.

6 cl, 7 tbl, 6 ex

FIELD: medicine; hygiene.

SUBSTANCE: application of an extract of the milk obtained from milk, at least, of one animal family horse for manufacturing of a preparation for sexual hygiene, containing 0.1-20 wt % of the specified extract from mass of a solid and a preparation for the sexual hygiene, containing such extract of milk is offered. The preparation can represent female disinfectant gel, female disinfectant shampoo, female disinfectant soap, vaginal disinfectant liquid, vaginal suppository, vaginal pill, concentrate, sparkling tablet, powder, cool-dehumidified lactic acid bacillus preparation etc. The preparation can be executed in the form of an adsorbing material, dry or wet napkin, hygienic lining or a vaginal tampon.

EFFECT: preparation is effective for prevention; treatments and aftertreatment of vaginitis and vulvitis; promotes conservation eubacteriosis of an organism and effectively prevents vaginal dryness.

16 cl, 6 ex, 1 tbl

FIELD: medicine, in particular balneology and physical therapy.

SUBSTANCE: claimed additive contains dihydroquercetin or mixture of dihydroquercetin and milky whey in ratio from 2:1 to 1:2 as biologically active additive for balneological bath agent. Dalneological bath agent includes base, osmolytically active components such as glycerol and inorganic salts, as well as biologically active additive of plant and/or animal origin, wherein osmolytic activity is 7700-11000 mOsm/l. As biologically active additive of plant and/or animal origin it contains dihydroquercetin or mixture of dihydroquercetin and milky whey in ratio from 2:1 to 1:2 and as the base it contains water and/or concentrated milk in the next component ratio (mass %): glycerol 25.0-30.0; inorganic salts 10.0-15.0; dihydroquercetin or mixture of dihydroquercetin and milky whey 0.2-1.0; and balance: water and/or concentrated milk up to 100 %.

EFFECT: new effective additive for balneological bath agent.

5 cl, 9 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, particularly to a lipid peroxidation inhibitor. Application of the dietary supplement Provitam as a lipid peroxidation inhibitor.

EFFECT: dietary supplement Provitam is an effective lipid peroxidation inhibitor.

3 tbl, 2 ex

FIELD: food industry.

SUBSTANCE: invention is related to phytotherapy. The biologically active supplement possessing antidepressant effect contains L-tryptophan, linseed-oil and vegetal components. The vegetal components are represented by oil extract of mother-of-thyme herb, common origanum herb, St.-John's wort herb, sandy everlasting blossom, common valerian root with rhizomes and elecampane root with rhizomes taken in a ratio of 0.8-1.2:0.8-1.2:0.8-1.2:0.8-1.2:0.8-1.2:0.8-1.2 accordingly and a dried water extract produced by way of expression of the same components after oil extraction. The biologically active supplement production method envisages mixture of the above components. The oil extract is produced by extracting the vegetal raw material with vegetable oil at a temperature of 50-70°C during 5-10 h with subsequent separation of the raw material. The water extract is produced by extracting the raw material, expressed after oil extraction, with water at a temperature of 50-70°C during 5-10 h with subsequent filtrate filtering and drying to produce the dry solid.

EFFECT: invention enables production of a supplement that is efficient in therapy of different forms of stress including sleep disturbance with patients of different age groups, aggressiveness, instability of temper, state of anxiety, has a positive effect on normalisation of the brain electrical activity indices and basic brain blood circulation indices and possessing antioxidant action.

9 cl, 4 tbl, 1 ex

FIELD: food industry.

SUBSTANCE: invention is related to phytotherapy. The biologically active supplement possessing antidepressant effect contains L-tryptophan, linseed-oil and vegetal components. The vegetal components are represented by oil extract of mother-of-thyme herb, common origanum herb, St.-John's wort herb, sandy everlasting blossom, common valerian root with rhizomes and elecampane root with rhizomes taken in a ratio of 0.8-1.2:0.8-1.2:0.8-1.2:0.8-1.2:0.8-1.2:0.8-1.2 accordingly and a dried water extract produced by way of expression of the same components after oil extraction. The biologically active supplement production method envisages mixture of the above components. The oil extract is produced by extracting the vegetal raw material with vegetable oil at a temperature of 50-70°C during 5-10 h with subsequent separation of the raw material. The water extract is produced by extracting the raw material, expressed after oil extraction, with water at a temperature of 50-70°C during 5-10 h with subsequent filtrate filtering and drying to produce the dry solid.

EFFECT: invention enables production of a supplement that is efficient in therapy of different forms of stress including sleep disturbance with patients of different age groups, aggressiveness, instability of temper, state of anxiety, has a positive effect on normalisation of the brain electrical activity indices and basic brain blood circulation indices and possessing antioxidant action.

9 cl, 4 tbl, 1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to biotechnology and represents a method of producing a natural L-amino acid - peptide biocomplex. The method involves preparation of material in form of a collection of native paunch manure of ruminant animals, extraction of said material, filtration and cooling for 6 hours at temperature (-50°C), sublimation drying and packing. Extraction is carried out with 2.0-3.0% aqueous NaCl solution in volume ratio of material to extraction agent equal to 1:1 for 45-48 hours at 18-20°C while stirring constantly. Sublimation drying is carried out for 20-24 hours at 43-45°C.

EFFECT: invention enables more efficient production of L-amino acid - peptide complex with high content of essential amino acids.

1 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to methods of treating obesity. Method of losing weight includes application as food additive of silica hydrosol in day dose 100-1000 g before/after, instead of food intake with addition of various in taste and properties food additives. Duration of intake course constitutes from 2 to 96 weeks.

EFFECT: invention allows to improve absorbing and bacterial properties, as well as taste quality of applied additive, increase convenience of its application.

1 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to methods of treating obesity. Method of losing weight includes application as food additive of silica hydrosol in day dose 100-1000 g before/after, instead of food intake with addition of various in taste and properties food additives. Duration of intake course constitutes from 2 to 96 weeks.

EFFECT: invention allows to improve absorbing and bacterial properties, as well as taste quality of applied additive, increase convenience of its application.

1 ex

FIELD: food industry.

SUBSTANCE: invention relates to food industry and biotechnology in particular, to production of natural powders of viscous liquids and may be used for production of a biologically active food supplement of quail eggs. The method for production of a biologically active food supplement of quail eggs envisages washing fresh eggs in running water at a temperature of +40°C, drying with sterile air and disinfection with 70° rectified alcohol during 5-7 minutes. Eggs together with shell are milled till indiscrete homogeneous mass production in a sterile box, filtered and poured into pans. The mass is frozen at a temperature of -60°C - -65°C and dried in a lyophiliser under a negative pressure which is equal to or in excess of 50 micrometres of mercury column at a temperature of +40°C during 48 hours. The dried product is milled and packed into gelatinous capsules to produce the finished biologically active food supplement of quail eggs.

EFFECT: invention allows to create a high-tech method for production of a biological food supplement of quail eggs wherein all the natural properties of fresh quail eggs (enriched with soluble calcium) are preserved during 12 months at a storage temperature of +4-25°C.

2 cl, 4 tbl

FIELD: medicine.

SUBSTANCE: invention refers to clinical nutrition. A method of the long-term enteral nutrition of a senile patient includes the following stages: long-term enteral introduction to a senile patient at least once a day of a nutritious product containing: protein source which contains 14-20% of the calorie count; carbohydrates source which contains 10-50% of the calorie count; fat source which contains 30-45% of the calorie count; dietary fibres source which makes 10-25 g per 1 litre of the product and 8.0-18.0 mcg of chrome per 100 kcal of the product. In 100 kcal of the product the composition contains at least: 30 mg of choline, 5.0 mg of taurine and 3.0 mg of carnitine; one or more of at least: 0.1 mg of beta-carotene, 0.2 mg of lycopene and 0.05 mg of lutein. As a version, the composition described above for the long-term enteral nutrition of a senile patient contains sufficient amount of mineral substances (particularly, calcium) and vitamins (particularly, vitamin D).

EFFECT: invention allows to provide a senile patient with the effective long-term enteral nutrition which optimises a glycaemic response for glycemia control, reduces insulin resistance and/or modulates a glucose response, and also maintains the metabolic status.

30 cl, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to clinical nutrition. A method of the long-term enteral nutrition of a senile patient includes the following stages: long-term enteral introduction to a senile patient at least once a day of a nutritious product containing: protein source which contains 14-20% of the calorie count; carbohydrates source which contains 10-50% of the calorie count; fat source which contains 30-45% of the calorie count; dietary fibres source which makes 10-25 g per 1 litre of the product and 8.0-18.0 mcg of chrome per 100 kcal of the product. In 100 kcal of the product the composition contains at least: 30 mg of choline, 5.0 mg of taurine and 3.0 mg of carnitine; one or more of at least: 0.1 mg of beta-carotene, 0.2 mg of lycopene and 0.05 mg of lutein. As a version, the composition described above for the long-term enteral nutrition of a senile patient contains sufficient amount of mineral substances (particularly, calcium) and vitamins (particularly, vitamin D).

EFFECT: invention allows to provide a senile patient with the effective long-term enteral nutrition which optimises a glycaemic response for glycemia control, reduces insulin resistance and/or modulates a glucose response, and also maintains the metabolic status.

30 cl, 2 ex

FIELD: food industry.

SUBSTANCE: group of inventions relates to food industry, in particular to production of food biologically active supplements (in tabletted form) containing organically bound iodine and intended for group or individual iodine hunger prophylaxis. The biologically active food supplement production method envisages mixing pectin and iodine solution prepared be way of crystal iodine dissolution in water solution of potassium iodide. Mixing pectin and iodine solution is performed by way of pectin moistening with the solution in a ratio of 1:0.8. One mixes iodine containing pectin at room temperature during an hour in a closed reactor with an anchor stirrer at 25 rpm. Calcium phosphate is added in a ratio of 1:3 to iodine containing pectin, extrusion is performed. The produced extrudate is subjected to granulation by spheronisation; formed granules are dried in a drying box with artificial ventilation at a temperature of 50°C till residual humidity is no more than 5%. Magnesium stearate is introduced in an amount of 1% to the granules weight; tabletting is performed. The biologically active food supplement contains crystal potassium iodide, pectin, calcium phosphate and magnesium stearate in a specific components proportion.

EFFECT: invention usage provides for production of a iodine containing organo-mineral complex in tabletted form with elementary iodine content in every tablet - 75 mcg, ingredients thereof promote optimisation of iodine metabolism and iodine fixation effectiveness due to enterosorption of strumogens.

2 cl

FIELD: food industry.

SUBSTANCE: food composition contains a food component with a moisture activity in excess of 0.7 and a bakery product such as a biscuit or a cake. Content of fat in the bakery product is less than 10% of the baked bakery product weight, the protein to fat weight ratio being at least 0.8:1.

EFFECT: invention allows to improve visual and organoleptic recognition of bakery product pieces in liquid or moist food product.

9 cl, 4 dwg, 1 tbl, 4 ex

Up!