FIELD: medicine, pharmaceutics.
SUBSTANCE: there is offered the administration of the preparation Histochrome (echinochrome, 2,3,5,6,8-pentahydroxy-7-ethyl-1,4-nahthochine, formerly known as an antioxidant) as a diuretic.
EFFECT: histochrome exhibits an evident diuretic action equal thiazide-type diuretics in intensity, does not cause associated hypokaliemia, has an absolute advantage over thiazide-type diuretics.
The invention relates to medicine, namely to pharmacology, and relates to means having a diuretic effect.
Currently known means, showing diuretic activity: loop diuretics, tiazidove diuretics, carbonic anhydrase inhibitors, potassium-sparing diuretics, spironolactone, diuretics vegetable origin.
Known drug, namely hydrochlorothiazide possessing diuretic effect [Glezer GA Diuretics. - M.: Interbook, 1993. - 352 S.]. Hydrochlorothiazide belongs to a group casinovip diuretics. Diuretic effect due to violations of the reabsorption of sodium ions and, as a consequence of water in the distal tubules of the kidneys. The drug is widely used in the treatment of diseases of the cardiovascular system, as well as other pathologies involving violations of water-electrolyte balance.
Hydrochlorothiazide has some significant drawbacks that limit its application. These include: gipokaliemicakie action diabetogenic effect, disorders of calcium metabolism and other
You know, the drug furosemide, possessing diuretic effect [Bryukhanov V.M., Zverev AF Side effects of modern diuretics. Novosibirsk: "Ceres", 2003. - 224 S.]. Furosemide belongs to the group of loop diuretics. Diuretic on the op perate has a breach reabsorption of sodium ions and as a consequence water in thick ascending Department of Genle loop. The drug is widely used in the treatment of diseases of the cardiovascular system, as well as other pathologies involving violations of water-electrolyte balance.
Furosemide has a number of disadvantages: the rapid weakening of the diuretic effect with repeated introductions, gipokaliemicakie action, the development of pseudohyperparathyroidism etc.
The technical result is an expanding Arsenal of diuretic funds.
The technical result is achieved by using as diuretics drug Histogram®.
Drug Histogram® is a pharmaceutical form of individual substances - natural quinoid pigments of marine invertebrates of echinochrome (2,3,5,6,8-pentahydroxy-7-ethyl-1,4 naphthoquinone, state registration number P No. 002363/01-2003).
Know the use of the drug Histogram® for the treatment of eye diseases (number of state registration of R No. 002363/02-2003) [RF Patent 2134107, A61K 35/56, 1999]. Histogram® is used in cardiology to reduce the size of myocardial infarction and prevention of reperfusion lesions of the myocardium (the state registration number R No. 002363/01-2003) [RF Patent 2137472, A61K 31/05, 1999], for the treatment of hemorrhagic stroke [RF Patent 2266737, A61K 31/05, 2005]. The drug entered in the Register of medicines, resolved to note the wetlands in the Russian Federation [the Big Russian encyclopedia of drugs, M., 2001, "Remedium", volume 2, s]. Pharmacotherapeutic group: anti-oxidant agent. The certificate of trademark registration 183145.
Histogram® is available in two dosage forms "Historom® solution for intravenous 1%" and "Histogram® solution for injection 0,02%"
"Historom® solution for intravenous 1%" prescribed for acute myocardial infarction in combination with thrombolytic drugs to eliminate caused by reperfusion complications. "Historom® solution for injection 0,02%" is used in dystrophic diseases of the retina and cornea, diabetic retinopathy, retinal hemorrhages into the vitreous body, retina, anterior chamber, with dyscirculatory violations in the Central artery and vein of the retina.
The use of the drug Histogram® as diuretics are not described in literature.
Brand new in the alleged invention is that the drug Histogram® can be used as a means of having diuretic activity.
New properties of the drug were found experimentally. The invention will be clear from the following description.
Experiments to study the diuretic properties of the drug Histogram® were carried out at 40 Wistar rats of both sexes weighing 180-220 g throughout the experiment the animals were the individual cells, adapted to collect urine in the conditions of free access to water and food. Under the terms of the experiment, rats were divided into two groups of 20 animals each. In the first (comparison group) for 10 days to rats subcutaneously administered hydrochlorothiazide dose of 20 mg/kg In the second (experimental group) for 10 days subcutaneously administered drug Histogram® at a dose of 10 mg/kg Every 2-3 days measurements were taken of the main indicators of kidney function is the volume of diuresis, urinary excretion of sodium and potassium ions, excretion of urine creatinine.
Statistical processing was performed using the Statistica for Windows 6.0". Expected average value, the standard error for the detection of significant differences used the criterion of student.
The results are shown in examples 1-2.
Example 1. It is established that the dynamics of the diuretic effect of hydrochlorothiazide in the experiment on rats is of the following nature. The level of urination in animals steadily increased, reaching a maximum on day 6 of experiments, when he exceeded targets by more than 4 times (table 1). Then after 10 days of administration of the drug diuretic response was somewhat weakened, still significantly outperforming the baseline - 3.2 times. It is important that the observed increased urination was accompanied by a significant INCR is the increase renal excretion of sodium ions, which is in good agreement with literature data. As can be seen from the experimental results, hydrochlorothiazide had no effect on the process of glomerular filtration, because the amount of excretion with urine creatinine throughout the experience remained unchanged. Thus, hydrochlorothiazide in the experiment on rats had a marked diuretic action, which arose due to violations of the reabsorption of sodium.
Example 2. Animals treated with Histogram®, diuretic effect was developed, starting from the third day, when the urination significantly increased 2.1 times. In the days that followed diuretic effect of the drug is further increased, reaching a maximum on day 7, when it exceeded control values by almost 5 times. Then in the last 10-day administration and even through the day after the drug level of diuresis was still characterized by high values, exceeding the original figures 4.1 and 3.7 times, respectively (table 2).
Against this background, not been a substantial increase in the excretion of urine sodium ions. Significant increased excretion of electrolyte was observed only on the 9th and 11th days of experience. This may mean that unlike hydrochlorothiazide histogram increases urination, not by inhibiting the reabsorption of sodium and due to other reasons. Partly osny diuretic effect of histogram can be explained by increased glomerular filtration, as in the experiment, there was an increase in the excretion of creatinine. Dynamics of increased excretion of creatinine were in the nature comparable to those described for the dynamics of urination: on the 5th day, there was an increase of the described indicator 2.8 times, on the 7th day - to 5.6-fold, 9-th and 11-th day - 3.8 and 3.3 times, respectively. However, a powerful diuretic effect of histogram, comparable in strength to the effects of hydrochlorothiazide, caused not only by increased filtering. Probably histogram exerts an inhibitory effect on the reabsorption of osmotically free water, which requires additional experimental evidence.
No less important is the fact that, as the experiments showed, histogram virtually no effect on the renal excretion of potassium ions. Significant increase in the excretion of urine of this electrolyte was observed only on the 9th and 11th days of experience. However, it is well known that the comparator drug hydrochlorothiazide, like all tiazidove diuretics, has a powerful calibrations action, leading to the development of hypokalemia, which is a very serious side effect .
Thus, the drug Histogram® has a strong diuretic effect, by force of which he is not inferior tiazidovy diuretics. Thus Historom® has a unique mechanism of mojego the aqueous actions it is much less effect on the reabsorption of sodium ions and causes only a small increase in the glomerular filtration rate. However, the main components in the mechanism of action require further in-depth study. Importantly, the drug Histogram® does not cause hypokalemia, therefore, has a definite advantage over tiazidnymi diuretics.
|The influence of long-term administration of dihlotiazid on excretory kidney function|
|Index||Control||3 day||day 6||day 10|
|The creatinine excretion (mmol/day)||5,0±0,14||4,6±0,42||5,0±0,41||5,3±0,39|
|Note: *- p<0.05 compared to control.|
|The influence of long-term administration of the drug Histogram® excretory kidney function|
|Index||Control||1 day||3 days||5 days||7 days||9 days||11 days|
|The sodium excretion (mmol/day)||37,7±3,20||29,1±4,10||31,4±2,93||32,7±4,07||45,4±4,27||57,0±11,7*||to 85.5±16,65*|
|The potassium excretion (mmol/day)||496,0±32,1||435,0±72,8||464,0±65,5||492,0±42,8||618,0±66,9||797,0±59,3*||870,0±66,3*|
|The creatinine excretion (mmol/day)||3.3V±0,34||3,0±0,50||2,3±0,28||9,2±1,20*||18,6±2,24*||12,7±2,71*||10,92±1,95*|
|Note:* - p<0.05 compared to control.|
The use of the drug Histogram as diuretics.
SUBSTANCE: invention relates to biologically active peptides, able to prevent sharp increase of permeability of vessel endothelium. Claimed is peptide of formula H-(N-Me)-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2 and its pharmaceutically acceptable salts.
EFFECT: peptide can be applied as anti-edema medication in various fields of medicine.
1 dwg, 2 ex
SUBSTANCE: invention relates to peptides of general formula , and to their cosmetically or dermopharmaceutically acceptable salts, where: X is chosen from the group formed by cysteinyl, seryl, threonyl and aminobutyryl; R1 is chosen from the group formed by H or a saturated linear C2-C24 acyl group; R2 is chosen from the group formed by an amino group optionally substituted with C1-C24 alkyl, or a hydroxy group. Besides the invention covers a method for making said peptides, their cosmetic or dermopharmaceutical compositions intended for reducing or eliminating baggy lower eyelids.
EFFECT: higher effectiveness.
12 cl, 7 ex
SUBSTANCE: invention refers to pharmaceutical compound to improve renal function that contains KW-3902 30 mg or its pharmaceutically acceptable salt, ester, amide, and furosemide. Also there are disclosed method to induce diuretic effect, method to improve renal function, method to support renal function and method to recover renal function in a patient.
EFFECT: effective recovery of renal function in patients with congestive heart failure.
13 cl, 2 tbl, 7 ex
FIELD: chemistry, pharmaceutics.
SUBSTANCE: invention relates to novel chemical composition from group quaternary ammonium salts of succinic acid, namely, 1-deoxy-1-N-methyl ammonium-D-glucitole succinate (meglumine succinate) .
EFFECT: obtaining chemical composition which acquires ability to impact on complex of pathological changes accompanying sugar diabetes.
4 cl, 6 tbl
FIELD: medicine, surgery.
SUBSTANCE: into area of brachial plexus due to inter-scalene access one should introduce medicinal mixture that contains 2 ml 2%-lidocaine solution, 0.2 ml 0.05%-proserine solution and 3 ml physiological solution. Injection could be also fulfilled due to axillary access. Before injection it is necessary to carry out electrodiagnostics. Thus, at the first stage one should introduce an electrodiagnostic needle into the axilla at the angle of 45 against skin, towards the caput of brachial bone to affect with the current at power being 1 mA, frequency of 2 Hz till the onset of muscular contractions. After that current power should be decreased up to 0.5 mA. Due to moving the needle mentioned, in case of muscular response it is important to inject medicinal mixture. At the second stage one should introduce the electrodiagnostic needle into area of intersection of imaginary line that connects the end of cricoid cartilage with a spinous process of the 6th cervical vertebra with inter-scalene sulcus, in direction 40-45 towards sagittal and frontal planes, for the depth of 0.5-1 cm. One should affect with current power of 1 mA till the onset of muscular contractions. After that current power should be decreased up to 0.5 mA. Due to moving the needle, in case of muscular response it is necessary to inject medicinal mixture. The procedure described should be fulfilled thrice, at 48-h-long interval. The innovation improves interstitial drainage due to creating the effect of "muscular pump".
EFFECT: higher efficiency of therapy.
1 ex, 3 tbl
FIELD: organic chemistry, medicine, cardiology.
SUBSTANCE: invention relates to (R)-2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridine dicarboxylic acid 3-(1-diphenylmethylazethidin-3-yl) 5-isopropyldiester of the formula (I): or its pharmacologically acceptable salts. Indicated compounds possess antagonistic activity with respect to calcium channels and anti-hypertensive activity and can be used in medicine in treatment of diseases of cardiovascular system.
EFFECT: valuable medicinal properties of compound.
7 cl, 3 tbl, 5 ex
FIELD: medicine, neurology.
SUBSTANCE: the present innovation deals with treating cerebrasthenic syndrome (CS) due to carrying out therapy at taking into account the data of a child's complex inspection. At bioelectric cerebral activity a rest being under 40 mcV and impossibility to reconstruct its background values after functional loadings during 3 min by EEG, deviation of cerebral neuromediator supply by 10% and more, affected fermentative activity along with decreased utilization of glucose and creatine phosphate synthesis according to electromagnetic cerebral scanning (EMS) data it is possible to establish CS as a result of oxygen-dependent cerebral hypoergia to introduce amino acids, enzymes, iron preparations, vitamins, hepatoprotectors during 1-mo-long period; then - nootropes and sedative preparations and then comes transcranial micropolarizations (TCMP) along the intake of antihypoxants and vitamin and microelements complexes. Such therapeutic courses should be repeated twice or thrice at interval being not less than 2 mo at keeping soft daily schedule. In case of analogous EEG alterations, the deficiency of initial pulse circulation in carotid and vertebral-basilary (VB) basin being not less than 10%, and during carrying out functional samples - up to 55-75% against the norm, the signs of venous outflow difficulties at REG and USDG, and decreased activity of neurons by above 20% according EMS data it is possible to state upon CS at VB failure and the risk for syncopic states; also, in therapy one should additionally apply vasoactive, spasmolytic and diuretic preparations for 1 mo, and after TCMP the course of resolution therapy should be conducted. In case of instability of vertebro-motor segments and ligamentous-muscular apparatus of cervical vertebrae and rotation subluxations C1 or C2 at wave deviation being above 0.2 mm according to EMS data, and at availability of vascular abnormality of brain or neck it is necessary to fulfill MRT at vascular program. In case of pronounced instability, and/or functional blocks at the level of C1-C5, and/or shifts of disks or vertebral bodies it is important to conduct manual therapy of cervical department at "soft techniques", except those at inborn abnormality of cranio-vertebral area. The innovation provides rapid and stable effect due to differentiating complex therapy at taking into account all the links of etiopathogenesis.
EFFECT: higher efficiency of therapy.
4 cl, 3 ex
FIELD: medicine, chemical-pharmaceutical industry, pharmacy.
SUBSTANCE: invention proposes a composition possessing anti-hypertensive and diuretic activity with prolonged release of an active component. The composition comprises an envelope-covered core comprising indapamide as an active component and ludipress, hydroxypropylmethylcellulose, aerosil and stearate as accessory components. The core is covered by a film-forming envelope that is based on hydroxypropylmethylcellulose preferably and comprising additionally polyethylene glycol, glycerol, talc, titanium dioxide and lactose. Method for preparing the novel composition involves mixing indapamide and accessory components followed by forming the prepared mixture to form the core of required configuration and size and applying the envelope. The composition is characterized by continuous release of indapamide, high fracture and abrasion strength, stability of active component during storage with the fitness time above 2 years.
EFFECT: improved preparing method, improved and valuable properties of composition.
9 cl, 2 tbl, 4 ex
FIELD: pharmaceutical industry, in particular, in particular solid pharmaceutical formulations useful in treatment of arterial hypertension and chronic heart failure.
SUBSTANCE: claimed formulation comprises core containing (mass %): inapamide 0.3-2.0; colloidal silica 0.1-2.5; hydroxypropyl cellulose 8-35; vinyl pyrrolidone-vinyl acetate copolymer 1.8-4.5; magnesium stearate 0.1-1.0; lactose 15.0-55.0; and balance: microcrystalline cellulose; and sell dissolvable in stomach and containing (mass %) polyethylene glycol 10.0-17.0; titanium dioxide 11.5-20.5; talk 1.8-6.3; and balance hydroxypropylmethyl cellulose. Method for production of said formulation also is provided.
EFFECT: Agent with gradual releasing of active ingredient; tablets with increased mechanical strength; preparation of improved quality in storage process.
3 cl, 1 tbl, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention belongs to pharmaceutical chemistry and medicine, refers to pharmaceutical composition for treatment of cardiovascular and nervous systems diseases as well as diseases connected with mitochondrial energetics and free radical formation disorders; invention includes active agent - 6-decaprenyl-2,3-dimethoxy-5-methyl-1,4-benzochinon, anionic surfactant, oil- and/or water-soluble emulsion stabiliser, water, powder; invention also refers to composition-obtaining method.
EFFECT: invention ensures obtaining of steady powder-composition of high biological availability, storage-stable during 39 months.
4 cl, 1 tbl, 4 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to chemical and pharmaceutical industry, notably to development of capsule with turgescent coating made of agar-agar with or without addition of water-soluble biologically active compounds, filled with oily solutions of oil-soluble vitamins and/or herbal oily extracts and/or fatty oils or fatty oils mixtures. Solution for encapsulation is prepared in the following manner: plastifier is added to water, stirred till complete dissolution, then agar-agar is added and left to turgesce at 15-40°C during 0.1-10 hours, preferably about 0.5-2 hours; then obtained mixture is stirred at 70-99°C, preferably at 80-98°C, most preferably at 95°C till mixture will become homogenous and transparent. Then capsules are manufactured as follows: solution is delivered in extruder which extrudes capsules at 77-99°C, preferably at 82-90°C, most preferably at 86°C; extruding rate is 1-10 capsules per second, preferably 3-6 capsules per second, cooling fluid's temperature is 3-15°C. Higher density of capsule agar covering is achieved by subsequent exposure to solution of polyol during 0.1-30 minutes, preferably 0.5 minutes, then to ethanol, preferably 95%, during 1-20 minutes, preferably 5 minutes.
EFFECT: capsules are resistant to temperature and humidity gradients, free of animal proteins thus excluding prionic infections.
16 cl, 27 ex
SUBSTANCE: invention refers to medicine, particularly psychoneurology, and concerns treatment of congenital structural myopathies and muscular dystrophies. That is ensure by the energotropic therapy consisting in the administration of L-carnitine in dosage 20-30 mg/kg/day, coenzyme Q10 in dosage 60-90 mg/day, succinic acid - 200 mg/day, citric acid - 50 mg/kg a day, vitamin B1 - 100 mg/kg a day, vitamin B6 - 200 mg a day, vitamin B12 - 200 mg/day for two months two times with an interval of two months.
EFFECT: such complex of drug therapy including the administration of coenzyme Q10 in high dose combined with the developed regimen provides motion activity increase in children suffering structural myopathies and congenital muscular dystrophies due to the integrated effect on various links of mitochondrial exchange.
2 ex, 7 dwg
SUBSTANCE: invention relates to medication including complex iron (III) compounds with carbohydrates, which have redox potential at pH 7 from 324 mV to - 750 mV relative to normal hydrogen electrode (NHE) and active redox substance, in which carbohydrates are selected from group consisting of dextranes, dextrines, oxidised or hydrogenised dextrines, as well as of pullulan, oligomers of said and/or hydrogenised pullulans, and in which redox substance (substances) are selected from group consisting of ascorbic acid, vitamin E, cysteine, physiologically acceptable phenols/polyphenols, selected from group consisting of quercitin, rutin, flavones, flavonoids, hydroquinones and glutathione.
EFFECT: said medication is intended for peroral introduction and is applied for treatment of states of iron deficiency without manifestation of unfavourable effects, such as formation of ulcerations in gastro-intestinal tract and oxidative stress.
19 cl, 6 tbl, 4 ex
FIELD: chemistry; pharmaceutics.
SUBSTANCE: present invention relates to novel cyclohexane derivatives of formula (I) or their pharmaceutically acceptable salts having inhibitory effect on Na+-glucose cotranspoter (SGLT2), as well as to pharmaceutical compositions based on the said compounds and their use in preventing or treating diabetes, diabetic complications caused by hyperglycaemia or obesity. , where A is -O-; n is an equal to 0 or 1; R6 and R7 each independently represents a hydrogen atom or a C1-C6alkyl group, m is an integer selected from 1-3; Q is selected from Q1 - Q5, given in formula 2.
EFFECT: obtaining novel cyclohexane derivatives or their pharmaceutically acceptable salts and preparation of a pharmaceutical composition based on the said compounds.
15 cl, 19 dwg, 11 tbl, 86 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to chemical-pharmaceutical industry, and concerns a pharmaceutical neuroprotective and antioxidant composition containing 100-250 mg of 3-oxipyridine or its pharmaceutically acceptable derivative, or pharmaceutically acceptable salt of this derivative, 400-500 mg of pharmaceutically acceptable magnesium derivative and 10-50 mg of pyridoxine or its pharmaceutically acceptable derivative, and additionally, it contains 10-50 mg of nicotinamide and 15-30 mg of a substance chosen from idebenone or ubiquinone (coenzyme Q10), and the method of treatment and/or prevention of neurotic and pseudoneurotic conditions, conditions associated with oxidative stress, organic psychosyndrome caused by disturbed cerebral circulation, discirculatory encephalopathy, craniocerebral injury, various intellectual mnestic disorders, abstinence syndrome, acute disturbed cerebral circulation, intoxications caused by antibiotics that involves introduction of the pharmaceutical composition under the invention in therapeutically effective amount to an indigent individual.
EFFECT: more expressed synergism of components ensured in comparison with a prototype.
8 cl, 4 ex
SUBSTANCE: invention refers to pharmaceutical, cosmetic and food industries, and represents method for making a water-soluble form of coenzyme Q10 representing an incorporation complex of β-cyclodextrine with coenzyme Q10 wherein molar ratio of β-cyclodextrine and coenzyme Q10 makes approximately 1:1, differing that β-cyclodextrine is dissolved in water at temperature 30°C to boiling temperature, preferentially 55°C to boiling temperature, then solid coenzyme Q10 is with continuing agitation at temperature 60-70°C, and then at room temperature.
EFFECT: higher water-solubility of said water-soluble form, improved biological digestibility and efficiency.
8 cl, 5 ex, 7 tbl, 5 dwg
SUBSTANCE: present invention refers to the new benzotropolone derivatives of general structural formula (A) as well to their pharmaceutically acceptable salts which are able to inhibit the replication of HIV-virus, to pharmaceutical composition thereof and to the method of inhibition of HIV-virus replication. formula (A) where R1 is hydrogen; R2 is OC1-6alkyl; each of R3, R4, R5 independently is hydrogen; G is selected from the group consisting of the structures I, II; R6 is hydrogen; R7 is (CH2)bCOOR9 where b takes up the integer values from 1 to 5; R8 is selected from C1-6alkyls substituted with one or more halogen atoms; W is O; R9 is selected from hydrogen or C1-6alkyl. The structures I, II are represented in the formula of invention.
EFFECT: claimed compounds inhibit the replication of HIV-virus.
4 cl, 6 dwg, 7 ex
SUBSTANCE: present invention refers to the new benzotropolone derivatives of general structural formula (A) as well to their pharmaceutically acceptable salts possessing anti hiv-activity, to the pharmaceutical composition thereof and to the method of HIV-integrase inhibition. formula (A) where R1 is selected from the group consisting of the hydrogen and halogen; R2 is selected from the group consisting of the hydrogen and OC1-6alkyl; each of R3, R4, R5 independently is hydrogen; G is selected from the group consisting of the structures I, II; R6 is hydrogen; R7 is COOR9; R8 is selected from C1-6alkyls substituted with one or more halogen atoms; W is O; R9 is selected from hydrogen or C1-6alkyl. The structures I, II are represented in the formula of invention.
EFFECT: claimed compounds possess anti HIV-activity.
5 cl, 6 dwg, 13 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention concerns a chemicopharmaceutical industry and a medical product for injection containing 6-dekaprenil-2,3-dimetoxy-5-methyl-1,4-benzoquinone (ubiquinone or ubinone) in an organism at preventive maintenance and treatment of various diseases, and also for restoration of performance efficiency and to the method of its obtaining. The method of obtaining consists that certain quantities of a non-ionic surface-active substance and an antioxidant are admixed, heated up to 40-120°C, necessary quantities 6-dekaprenil-2,3-dimetoxy-5-methyl-1,4-benzoquinone are dissolved in the obtained solution, and the obtained admixture at intensive hashing is flown in an isotonic solution preliminary heated to 30-100°C with the subsequent sterilisation of the received composition. The offered invention allows to receive the water-oil emulsions containing 6-dekaprenil-2,3-dimetoxy-5-methyl-1,4-benzoquinone, for injection in an organism.
EFFECT: possibility to reach the maximum concentration of operating substance in blood practically at once.
3 cl, 4 ex
FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to biologically active compounds. Agent represents 3,6-dioxocyclohexa-1,4-diene-1,2,4,5-tetrasulfonate sodium. The new agent elicits antioxidant properties and therefore it can be used in food industry, in pharmaceutical compositions and cosmetic products. Also, the new agent elicits antiviral activity owing to it can be used as both the independent medicinal agent and in compositions with other preparations used for treatment of viral infections.
EFFECT: expanded assortment of medicinal agents and antioxidants, realization of indicated prescription.
1 tbl, 8 dwg