Method of intravascular thrombocyte activity correction in children with scoliosis

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology, and orthopaedics. The intravascular thrombocyte activity correction in children with scoliosis requires the prescription for at least 6 months of a therapeutic complex which involves daily therapeutic physical training, two courses of massage and daily swimming for at least 20 minutes a day.

EFFECT: method allows to normalise intravascular thrombocyte activity in children aged 8-12 with scoliosis, to improve tissue microcirculation considerably, to optimise growth and development of skeleton and internals.

7 ex

 

The invention relates to medicine, namely to Hematology, and orthopedics.

Analogues of the proposed method the normalization of intravascular platelet activity (Wat) in children 8-12 years old with scoliosis does not exist.

There are recommendations for the appointment of children with scoliosis medical physical culture (physical therapy), massage and swimming.

However, never before medical complex, consisting of daily exercises, two courses of massage and daily swimming at least 20 minutes a day was not used in children 8-12 years old with scoliosis to normalize BAT.

The aim of the invention is to increase the efficiency correction activation of BAT in children with scoliosis.

The essence of the proposed method lies in the fact that for the correction Wat kids 8-12 years old with scoliosis are assigned daily physiotherapy exercises, two courses of massage and daily swimming at least 20 minutes a day.

The method allows to normalize Wat in children 8-12 years old with scoliosis within 24 weeks, taking it to the level characteristic for healthy children. Subject to the subsequent recommendations of the proposed method can be maintained at them Wat optimally functioning, which will significantly improve the microcirculation of tissues, accelerating growth and development, ozdorovyv of the child and to promote the full deployment of its growth and development.

Ocekavat is performed in the following way (A.S. Shitikova et al. Method for the determination of intravascular platelet activity and its value in clinical practice. // Clinical laboratory diagnostics, 1997, No. 2. - P.23-35). Of the needle introduced into the cubital vein, pour 2-3 ml of blood on the cotton wool and the following 2 ml poured into silikonizirovannaya centrifuge tube with 8 ml of 0.125% glutaraldehyde. This tube is filled first before all other samples recruited for the study of hemostasis. The obtained blood was immediately centrifuged for 6 min at 1000 rpm In the case of incomplete precipitation of red blood cells (supernatant pink) take 2 ml of the supernatant to another tube and centrifuged in the same mode for 1 minute. The supernatant is diluted with a solution of glutaraldehyde four times (0.1 ml + 0.3 ml solution), mix by pipette 5 times and fill the camera Goryaeva, which is placed for 20 min in a humidified Petri dish.

To determine the absolute content of platelets in 109/l blood filled chamber Goryaeva in five large squares counted the number of all individual blood platelets, regardless of their form. The obtained value for the calculation of the content of platelets in 109/l blood must be multiplied by 5×4×10×5×106=1×109where the first two digits - the amendments made in the course of the study, cultivation of blood, the second two digits the - amendments related to the height of the camera Goriaev (0.1 mm) and with square, which were counted platelets (5 large squares = 1/5 mm2), 106- the conversion factor 1 mm3in 1 L. of Determining the absolute content of platelets in the study of blood, translate relative values of individual forms of platelets (in %) in the absolute content of 109/l blood. The absolute value of the pathology can more adequately reflect changes in the designated distribution forms.

In the same drug count the number of aggregates of different sizes (i.e. containing 2, 3, 4, 5, etc. of blood platelets)per 500 free platelets. The result judged by the distribution of aggregates of different sizes per 100 of free platelets. To facilitate analysis of the distribution of agregatogramme the obtained results can be summarized in terms of two quantities: 1) the number of units of small size, containing 2-3 platelet, and 2) the number of units of medium and large size, containing 4 or more platelets. Change these values in pathological conditions more clearly reveals the increase of intravascular activation of blood platelets.

The assessment of the degree of aggregation is also on the relative number of platelets, which are involved in the aggregation reaction. The village is ednie can be identified according to the percentage ratio of the number of egregiously of platelets to the total number of drug (i.e. to the amount of free-lying cells and involved in the aggregation) by the formula:

where x, y, z, etc. is the number of units of appropriate size per 500 free platelets. This formula cannot be applied in the case when the drug are irreversible, optically homogeneous units or so large that they are impossible to count the number of cells. In this case, is limited to data distribution of aggregates of different sizes. The inventive method is carried out as follows.

The range of normal fluctuations in the values of BAT and their average values in healthy children is presented in table 1.

Table 1
The range of normal fluctuations and average values Wat in healthy children (8-12 years)
IndicatorsThe range of normal fluctuations and the average value
The number of platelets in venous blood - 109/l142,7-223,7-324,7
Various FORTS platelets:
Discocyte, %81,5-86,6-to 91.6
Disco echinocyte, % 5,4-9,8-14,2
Sphericity, %0,5-1,7-3,0
Sphere-echinocyte, %0-1,3-2,6
Bipolar form %0-0,3-2,0
The amount of active form of platelets, %7,9-12,8-17,7
The number of platelets involved in units %6,1-6,8-7,4
The number of small aggregates (2-3 platelet 100 free platelets)2,81-3,16-3,51
The number of medium and large units (4 platelet and more than 100 free platelet)0,03-0,13-0,23

When registering higher values Wat children with scoliosis is assigned the developed correction method.

The first component method recommended exercise, is shown below.

The complex consists of several parts: warm-up (UPR), exercises lying on your back, lying on his stomach, and standing. Rest between exercises is in the initial position (i.e. if the exercise is lying on his back, resting in this position, stand or sit is not necessary).

1. Unloading of the spine. All exercises gymnastics traditionally begin what I exercises for the unloading of the spine. Classic exercise - walking on all fours. The duration of 2-3 minutes. Lie on a Mat on your back. Exercises for the back are intended primarily for strengthening the muscles of the abdominals.

2. "Stretching" of the spine. Lying on your back, heels are drawn down, the top - up. Perform 3-4 "traction" for 10-15 seconds.

3. A Bicycle. Lying on your back, hands behind your head or across the body, legs made motion that simulates riding a bike. Important: most of the amplitude of the movements of the legs must be "below" the body, kicking your legs over your abdomen is not necessary, it is necessary to straighten the legs in turn passed close to the floor. Tempo run - average. Perform 2-3 sets of 30-40 seconds.

4. The scissors. Lying on your back, hands behind your head or across the body, performed the surrounding horizontal and vertical legs swinging. Important: parentline Mahi is desirable to produce closer to the floor. Tempo run - average. Perform 2-3 sets of 30-40 seconds. Now turn over on your stomach. Exercises for the abdomen are intended primarily to strengthen various muscles of the back.

5. The traction. Is similar to exercise 2, only on the abdomen.

6. The swimming. Starting position lie on your stomach, legs straight, his head rests on the back of their hands. SAG in the back (head, upper torso, arms and legs raised, the fulcrum - belly). While holding this position, perform movements that mimic swimming breaststroke:

arms, legs diluted in hand

your arms, legs connect

hands to the shoulders, legs still together

Perform 2-3 sets of 10-15 repetitions with short rest between sets (5-10 seconds).

7. The scissors. Lying on his stomach, legs straight, his head rests on the back of their hands. Raised feet and performed the surrounding horizontal and vertical legs swinging. Important: when performing this exercise, the hips need to be off the floor. Tempo run - average. Perform 2-3 sets of 30-40 seconds.

8. Hold. Lying on his stomach, legs straight, his head rests on the back of their hands. Raise legs and upper body, bending at the waist (head, upper torso, arms and legs raised, the fulcrum - belly). Feet together, hands at sides, palms turned up. Statically freeze in this position for 10-15 seconds. Important: it is advisable not to hold your breath when performing this exercise, the hips need to be off the floor. Perform 3-4 repetitions with short rest between repetitions (5-10 seconds).

Then the child gets up.

9. Rotation of the arms. Exercise for securing blades. Standing before the mirror (controlling posture), elbows to the side of the fingers to the shoulders. Performed the rotation of the hands backwards (clockwise p is the left main coronary artery). Important: this exercise does not need a large amplitude motion, on the contrary, the elbows should be performed when the rotation of the small circle. The pace of implementation is slow. Perform 2-3 sets of 20-30 seconds with a short rest between sets.

10. Squats. Exercise for posture. Standing before the mirror (controlling posture, arms at side, palms turned up. In this position, keeping good posture, stand on toes, then squatted again on the toes and in its original position. Perform 5-10 of these squats with short-term rest. The pace of the exercise is slow.

The second component of the claimed method is to conduct two courses of massage.

Massages start from the back, from the side of the curvature, then massaged his neck, lower back, and chest muscles.

Use the following techniques: stroking of all kinds, rubbing, squeezing, kneading and vibration. Massage techniques in scoliosis apply depending on muscle tone. The duration and rhythm of their performance should be the same on each massaged the area to complete muscle relaxation. Massage techniques alternate stroking and shaking. Subsequent massages help to strengthen muscles and improve their tone.

Back massaged lying on his stomach, under his belly and under the ankle joints enclose Velikiye small pillows, hands lowered along the torso, the head is rotated in the direction opposite to the scoliosis. Best if you massage the thorax and abdomen is the supine position, and under the head and knees better to put the soft cushions. The hands of the patient extends along the body. Massage side surfaces of the body in position of the child lying on the side opposite to the curvature of the spine. The duration of the massage is 30-40 minutes daily, course of treatment consists of 20-25 sessions within six months courses of massage is carried out twice, at the beginning of treatment and 3 months after the end of the first course.

When performing massage the position of the patient is lying on his stomach (therapist is right), lying on the back (therapist to the left of the patient) or lying on the opposite side of the thoracic scoliosis (massage therapist behind the back).

A child with scoliosis lying on his stomach, the masseur is from thoracic scoliosis. First by General stroking the entire surface of the back plane, the bow, grebneobraznoi, Ironing), then carry out a sedative, relaxing effect on the upper part of the trapezius muscle (stroking, rubbing fingers - circular, vibration labile continuous), do the rubbing, kneading, vibration on an Eminence in the field of thoracic scoliosis (comb-shaped friction, effleurage, hack, kneading wipeabate long muscles of the back); all methods with the purpose of toning, stimulating performed locally. Then massage the area of the lumbar concavity (all techniques for relaxation, stretching, impact sedative - stroking, friction, vibration only labile, continuous).

The child turns on the left side. In this position, use the techniques of pulling the right iliac crest. After that, the child lies on his stomach. Continue to massage the area of scoliosis in the lumbar spine, in the area of convexity (all methods of stimulation, tone - kneading, vibration intermittent, all varieties for strengthening the muscle roller). Then carry out relaxation and subscapularis stretch region (left shoulder), paying attention to the intercostal space (grebneobraznoi stroking, rubbing, vibration labile), pulling the left corner of the scapula from the concavity of the spine, stimulate and tone the upper arm muscles above the left shoulder blade, the upper part of the trapezius muscle (rubbing, kneading, vibration, intermittent, and percussion techniques).

The child rolls over on his back. In this position, massages anterior surface of the thorax.

In the infraclavicular and supraclavicular areas, as well as in chest muscles on the left, all the methods use the I to stimulate, muscle strengthening (rubbing, kneading, vibration intermittent, percussion techniques). In the area of the front of the rib hump (protrusion) are techniques with pressure on this area with posterior movements, alignments; massage manipulations to stimulate, tone. On the anterior abdominal wall, abdominal press are all methods of stimulating, toning (rubbing comb, kneading, vibration intermittent, percussion). On the upper thoracic muscles doing all right techniques to relax and pulling the shoulder back, leveling the plane of the shoulder girdle levels. Complete full body massage by stroking the whole of the back, shoulder girdle.

The third component of the claimed method is the daily voyage of the child in the sea, river or pool for at least 20 minutes a day.

Example 1. The child B., age 9, with scoliosis of the first degree when the survey was revealed activation of BAT: discocyte 55%, disco echinocyte 25%, ferocity 13%, sphere-echinocyte 5%, bipolar form 1%, the number of platelet aggregates 13%, the number of small units 14, 100 loose platelets, medium and large units 7 100 loose platelets. The child was assigned to daily physiotherapy exercises. The child was regularly looked after the start of treatment. Simultaneously with the inspection was performed hematological analysis of blood./p>

To week 24 of treatment, the child signs of scoliosis has slightly decreased. Intravascular platelet activity weakly changed: discocyte 58%, disco echinocyte 22%, ferocity 13%, sphere-echinocyte 5%, bipolar form 2%, the number of platelet aggregates 9%, the number of small units 9 100 loose platelets, the number of medium and large units 5 100 loose platelets.

The parents were asked to apply the child in the subsequent treatment according to the inventive method.

Example 2. Child J., age 11, with scoliosis II degree when the survey was revealed activation of BAT: discocyte 56%, disco echinocyte 26%, ferocity 11%, sphere-echinocyte 5%, bipolar form 1%, the number of platelet aggregates 14%, the number of small units 14, 100 loose platelets, medium and large units 8, 100 loose platelets. The child had been appointed within six months two courses of massage. The child was regularly looked after the start of treatment. Simultaneously with the inspection was performed hematological analysis of blood.

To week 24 of treatment, the child has decreased signs of scoliosis. While intravascular platelet activity has changed only slightly: discocyte 61%, disco echinocyte 24%, ferocity 9%, sphere-echinocyte 4%, bipolar form 2%, the number of platelets in units of 10%, the number of small units 9 100 free is but lying platelets, the number of medium and large units 7 100 loose platelets.

Parents were invited to apply to the child treatment according to the inventive method.

Example 3. Child J., age 8, with scoliosis II degree when the survey was revealed activation of BAT: discocyte 58%, disco echinocyte 25%, ferocity 11%, sphere-echinocyte 4%, bipolar form 2%, the number of platelet aggregates 14%, the number of small units 18 100 loose platelets, medium and large units 7 100 loose platelets. The child was assigned to daily swimming in the pool at least 20 minutes a day. The child was regularly looked after the start of treatment. Simultaneously with the inspection was performed hematological analysis of blood.

To week 24 of treatment, the child has somewhat diminished signs of scoliosis and severity of intravascular platelet activity: discocyte 63%, disco echinocyte 23%, ferocity 9%, sphere-echinocyte 3%, bipolar form 2%, the number of platelet aggregates 11%, the number of small units 14, 100 loose platelets, the number of medium and large units 6 100 loose platelets.

Parents were invited to observe in the future in the treatment of the child the correction pattern according to the inventive method.

Example 4. The child K., age 12, with scoliosis II degree in the examination would be the and revealed activation of BAT: discocyte 57%, disco echinocyte 21%, ferocity 13%, sphere-echinocyte 8%, bipolar form 1%, the number of platelet aggregates 13%, the number of small units 19 100 loose platelets, medium and large units 7 100 loose platelets. The child was assigned to daily physiotherapy exercises and two massage course. The child was regularly looked after the start of treatment. Simultaneously with the inspection was performed hematological analysis of blood.

To week 24 of treatment, the child was weak signs of scoliosis, decreased the severity of intravascular platelet activity: discocyte 66%, disco echinocyte 20%, ferocity 8%, sphere-echinocyte 5%, bipolar form 1%, the number of platelets in units of 8%, the number of small aggregates of 5 to 100 loose platelets, the number of medium and large units 4 100 loose platelets.

The parents were asked to adhere to the treatment recommendations according to the inventive method.

Example 5. The baby M, age 10, with scoliosis of the first degree when the survey was revealed activation of BAT: discocyte 55%, disco echinocyte 25%, ferocity 13%, sphere-echinocyte 6%, bipolar form 1%, the number of platelet aggregates 12%, the number of small units 15 100 loose platelets, medium and large units 6 100 loose platelets. The child had been assigned daily activities of Lfci daily swimming in the pool at least 20 minutes a day. The child was regularly looked after the start of treatment. Simultaneously with the inspection was performed hematological analysis of blood.

To week 24 of treatment, the child decreased the severity of signs of scoliosis. Optimised intravascular platelet activity: discocyte 67%, disco echinocyte 19%, ferocity 7%, sphere-echinocyte 5%, bipolar form 2%, the number of platelet aggregates 7%, the number of small units 6 100 loose platelets, the number of medium and large units 5 100 loose platelets.

Parents were invited to observe in the child's treatment recommendations according to the inventive method.

Example 6. The child L., age 9, with scoliosis II degree when the survey was revealed activation of BAT: discocyte 54%, disco echinocyte 24%, ferocity 14%, sphere-echinocyte 7%, bipolar form 2%, the number of platelet aggregates 14%, the number of small units 14, 100 loose platelets, medium and large units 7 100 loose platelets. The child had been assigned two massage course and daily swimming in the pool at least 20 minutes a day. The child was regularly looked after the start of treatment. Simultaneously with the inspection was performed hematological analysis of blood.

To week 24 of treatment, the child reduces the severity of symptoms of scoliosis, weakened inside the vascular activity of platelets: discocyte 66%, disco echinocyte 20%, ferocity 8%, sphere-echinocyte 5%, bipolar form 1%, the number of platelets in units of 10%, the number of small aggregates of 5 to 100 loose platelets, the number of medium and large units 6 100 loose platelets.

The parents were asked to follow up with the child's treatment recommendations according to the inventive method.

Example 7. The child A., age 8, with scoliosis of the first degree when the survey was revealed activation of BAT: discocyte 56%, disco echinocyte 24%, ferocity 12%, sphere-echinocyte 6%, bipolar form 1%, the number of platelet aggregates 12%, the number of small units 15 100 loose platelets, medium and large units 6 100 loose platelets. The child was assigned to daily physiotherapy exercises, two courses of massage and daily swimming in the pool at least 20 minutes a day. The child was regularly looked after the start of treatment. Simultaneously with the inspection was performed hematological analysis of blood.

To week 24 of treatment, the child was neutralized signs of scoliosis. Optimised intravascular platelet activity: discocyte 82%, disco echinocyte 11%, ferocity 4%, sphere-echinocyte 2%, bipolar form 1%, the number of platelet aggregates 5%, the number of small aggregates of 2 to 100 loose platelets, the number of medium and large units of 0.05 to 100 free l is containing platelets.

The parents were asked to observe the child recommendations in the following.

The use of the proposed method of correction Wat in Hematology and orthopedics will not only help reverse the signs of scoliosis in a child, but also to optimize it microcirculation, ozdorovyv him, to optimize the growth and development of the skeleton and internal organs.

Method of correction of intravascular platelet activity in children with scoliosis, including the assignment for at least 6 months of daily practice of therapeutic physical culture, two courses of massage and daily swimming at least 20 minutes a day.



 

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10 cl, 10 dwg

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to gerontology and cardiology and can be used for reduction of pathologically increased biological age (BA) in patients with arterial hypertension (AH) with abdominal obesity (FO) and dyslipidemia. Essence of claimed method lies in the following: to patients administered is complex, that includes hypocaloric diet, calculated in kcal by formula: for women: 18-30 years old - (0.0621 × body weight, kg + 2.0357) × 240; 31-60 years old - (0.0342 × body weight, kg + 3.5377) × 240; over 60 years old - (0.0377 × body weight, kg + 2.7545) × 240; for men: 18-30 years old- (0.0630 × body weight, kg+ 2.8957) × 240; 31-60 years old - (0.0484 × body weight, kg + 3.6534) × 240; over 60 years old - (0.049 × body weight, kg + 2.4587) × 240. Also administered are rationally dosed static and dynamic physical loadings, including morning hygienic gymnastics, preventive medical gymnastics, fractional physical exercises during the day, daily swimming in swimming pool for not less than 60 minutes per day. Also introduced are medications simvastatin 10 mg 1 time before going to bed after meal and lisinopril 10 mg 1 time per day in the morning for not less than 7 weeks.

EFFECT: invention combines application of all components of complex allows to normalise BA within 7 weeks of treatment.

2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to hematology and cardiology and can be applied for reduction of spontaneous aggregation of erythrocytes (SAE) in case of stable stenocardia of I-II functional class (SS I-II FC) and arterial hypertension (AH). Substance of clamed method consists in the following: 2 month-long complex of hypolipodemic diet, dosed static and dynamic physical activities, which include morning hygienic gymnastics, medical-preventive gymnastics, separate physical activities during the day, daily swimming for not less than 30 min. per day in the middle of the day, intake of lisinopril in dose 10 mg 1 time per day in the morning and simvastatine 20 mg 1 time per day after meal.

EFFECT: combined application of all components allows normalising of SAE of patients with SS of I-II functional class and arterial hypertension due to exponentiation of their medical action during 2 months of treatment.

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology, and can be used for normalisation of adenosine diphosphate and adenosine triphosphate thrombocyte secretion activity in the patients with arterial hypertension and impaired glucose tolerance. That is ensured by graduated physical activities, daily swimming in a pool for at least 20 minutes a day, and also prescribed metformin 500 mg twice a day and lisinopril 10 mg once a day in the morning.

EFFECT: combination of therapeutic modalities enables rapid normalisation of adenosine diphosphate and adenosine triphosphate thrombocyte secretion activity that promotes prevention of thrombotic complications in the case patients.

9 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to cardiology, endocrinology, and can be used for normalising the blood α2 antiplasmin concentration in arterial hypertension and impaired glucose tolerance. That is ensured by graduated physical activities, daily swimming in a pool for at least 20 minutes a day, and also prescribed metformin 500 mg twice a day and lisinopril 10 mg once a day at regular hours in the morning. The therapeutic course is 1 months.

EFFECT: offered combination of therapeutic modalities enables normalising the blood α2 antiplasmin level in a relatively short time that promotes prevention of thrombotic complications in the case patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to cardiology, endocrinology, and can be used for normalising the blood plasminogen activator inhibitor concentration in arterial hypertension and impaired glucose tolerance. That is ensured by graduated physical activities, daily swimming in a pool for at least 20 minutes a day, and also prescribed metformin 500 mg twice a day and lisinopril 10 mg once a day in the morning. The therapeutic course is 1 months.

EFFECT: offered combination of therapeutic modalities enables normalising the blood plasminogen activator inhibitor in a relatively short time that promotes prevention thrombotic complications in the case patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to gerontology and cardiology, and concerns biological age reduction in arterial hypertension combined with abdominal obesity. That is ensured by the integrated treatment including a low-calorie diet, reasonable graduated static and dynamic physical activity, daily swimming in a pool for at least 30 minutes, and the introduction of lisinopril in dosage 10 mg once a day in the morning and metformin in dosage 500 mg twice a day for the therapeutic course of 7 weeks.

EFFECT: complex of drug-induced and drug-free therapy combined with empirically prescribed treatment length provides biological age reduction in the case patients estimated by the relation of electronegative cells to total count in a buccal epithelium scrape due to normalised DNA repair and chromosome fragility level.

2 ex

FIELD: medicine, narcology.

SUBSTANCE: one should detect satisfaction insufficiency syndrome due to performing genetic analysis by the presence of, at least, one of the genes coding the exchange of neuromediators being the constituents of human satisfaction system. One should compensate satisfaction insufficiency due to performing, at least, one complex of physical exercises. Moreover, in case of availability of pathological gene allele of dopamine D2 receptor and/or protein gene of reverse dopamine capture in patient one should apply the complex of physical exercises including those to provide sedative effect, and in case of availability of pathological gene allele of dopamine-beta-hydroxylase protein one should apply the complex of physical exercises including those that induce an activating effect. In case of availability of pathological gene allele of dopamine D2 receptor and/or protein gene of reverse dopamine capture one should apply additional food biologically active additives based upon amino acids being the precursors of neuromediators, such as taurine, D-, L-phenylalanine in combination with 5-hydroxytryptophan, hypericin and vitamin B6, and in case of pathological gene allele of dopamine-beta-hydroxylase protein one should additionally apply food biologically active additives based upon amino acids being the precursors of neuromediators, such as: taurine, tyrosine and/or dimethylaminoethanol, lecithin and group B-vitamins. The present innovation enables to take into account pathological disease mechanism.

EFFECT: higher efficiency of prophylaxis.

14 cl, 5 ex

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