Method of biological age reduction in abdominal obesity

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to gerontology, endocrinology, and can be used for pathologically raised biological age reduction in the patients with abdominal obesity. That is ensured by prescription of efficient graduated static and dynamic physical activity, daily swimming in a pool for not less than 30 minutes a day, and also administration of metformin in dosage 850 mg twice a day. The therapeutic course is 7 weeks.

EFFECT: offered combination of the modalities enables to adjust the biological and chronological ages that improves quality of life in the case patients.

2 ex, 1 dwg

 

The invention relates to medicine, namely to gerontology and endocrinology.

Analogues of the proposed method of reducing biological age in patients with abdominal obesity (AO) does not exist.

In the literature there are recommendations for the appointment of a balanced diet, swimming and physical exercise to delay age-related changes (Podkolzin A.A., Dontsov V.I. Aging, longevity and bioactivity, Moscow, 1996. - 144 C.), more focused on slowing the development of age-related changes in relatively healthy people. There is also information about applying rational diet (Savelyeva L. Modern approaches to treatment of obesity. // The doctor, 2000, No. 12 - p.12-14; Kadyrov, BC, Salhanov B.A. Nutrition in obesity. Alma-ATA, Kazakhstan, 1990), physical training (V. Moshkov. Exercise in obesity. M, “Medicine”, 1976. - 56 (C), and Metformin in patients with AO.

However, never before medical complex, consisting of a low-calorie diet, dosed physical activity, swimming and drug Metformin has been used in patients with AO to reduce their pathologically increased biological age.

The aim of the invention is the reduction of pathologically increased biological age of patients with AO.

The essence of the proposed method lies in the fact that to reduce pathologically above the aqueous biological age patients with AO for a long period of time is assigned to a low-calorie diet, dosed static and dynamic exercise, daily swimming in the pool at least 30 minutes a day and the drug Metformin at a dose of 850 mg 2 times a day.

The method allows to align biological and chronological age in patients with AO for 7 weeks. Subject to the subsequent recommendations of the proposed method may reduce the biological age below chronological, which will significantly improve the quality of life of patients with AO, to reduce their pathological burden, reduce the number of cases of temporary disability, to accelerate and improve the quality of patient treatment, to exclude disability, as well as extend the life and reduce mortality of patients with AO from heart attack and stroke.

The inventive method is carried out as follows.

To create a negative energy balance in the body, patients are advised individually selected low-calorie diet.

Calorie daily diet individually for each patient with AO is calculated in kcal by the formula:

for women 18-30 years (0,0621 × body weight (kg) + 2,0357)×240,

31-60 years (0,0342 × body weight (kg) + 3,5377)×240,

over 60 years of age (0,0377 × body weight (kg) + 2,7545)×240,

for men 18-30 years (0,0630 × body weight (kg) + 2,8957)×240,

31-60 years (0,0484 × body weight (kg) + 3,6534)×240,

over 60 years of age (0,0491× body weight, kg + 2,4587)×240.

The resulting coefficient remains unchanged with minimal physical activity, multiplied by 1.3 in moderate and 1.5 - high physical activity (usually in patients with MS, the level of physical activity low).

It is recommended that 3 main meals and 2 intermediate. With regular skipping one meal significantly increases the incidence of obesity, also revealed a positive correlation between obesity and skipping Breakfast. It is recommended that the following distribution of daily calories: Breakfast - 25%, 2nd Breakfast - 10%, lunch - 35%, tea - 10%, dinner - 20%.

To compile menu the patient uses a special table with the instructions of the chemical composition and caloric content of products, given that the main sources of energy: protein (1 g contains 4 kcal), fat (9 kcal), carbohydrates (4 kcal) and alcohol (7 kcal).

The second component of the proposed method is feasible regular physical exercise.

In real life you can implement the three forms of physical activity: 1) morning hygienic gymnastics (charging); 2) health care gymnastics; 3) fractional exercise during the day.

1. Morning hygienic gymnastics (charging).

Morning gymnastics should do after waking up to Breakfast in the p is for the room. Under the influence of training the body is released from the state of inhibition of the physiological processes taking place during sleep.

The sequence of the exercises involves the alternation of load on different muscle groups (arms, legs, body). Exercises are performed with gradually increasing excursion breathing, stretching, limited use of power conditions. Breathing exercise should be free, rhythmic, without delay, mainly through the nose; the exhalation should be longer than the inhale (breath in 2-3 sec, exhale 3-5).

In good health the load, you can increase the number of repetitions faster, increase range of motion and shorter pauses between exercises.

When fatigue should reduce the load, increase the duration of pauses between exercises, to fill their quiet breathing.

After gymnastics, you must go to the rubbing or take a shower.

Morning exercises should evoke a sense of vitality, increase activity, improve well-being and health.

If you feel unwell, develop shortness of breath or pain in the heart and behind the sternum should be temporarily suspend classes and consult a doctor.

During the day, patients with JSC recommended treatment and preventive exercises. Depending on the initial fitness applicatio is but the application in the beginning of lightweight option exercise, then the enhanced version.

2. Complexes of preventive and curative gymnastics for people with AO.

2.1. The lightweight version of preventive and curative gymnastics.

Exercise 1. Standing. A quiet walk with a gradual acceleration and deceleration 1-2 minutes on the exercise of the gradual deepening of the breath.

Exercise 2. Circular motion in the shoulder joints. When breeding - breath, when the note - exhale with a slight tilt of the torso and retraction of the abdominal wall 6-8 times. The fingers touch the shoulders, elbows close to the torso.

Exercise 3. Standing, hands on his belt. Alternately shifting the weight of the body from one foot to the other with a small bending the legs at the knee joint without lifting the feet from the floor. Exercise done 10-16 times with the muscles of the legs.

Exercise 4. Standing, feet apart at shoulder width, hands on his belt. Bending the trunk forward, touch right hand to left toe. 4-6 times alternately. When straightened position - breath, when the tilt - exhale. To look ahead.

Exercise 5. Standing with arms along the body. At the same time to take straight arm and one leg to the side with alternating lead leg. 4-6 times in each direction in turn. A wave of the hands and feet, breathe freely, do not delay.

Exercise 6. Standing, feet apart, hands in front of chest with palms down. With a turn of the body to move her arms in the part with turning the palms up - the breath. To return to the original position with a small tilting forward, exhale. 3-5 times in each direction in turn. Breathing to harmonize with the movement of hands and body. By the end of exhalation to engage the wall of the abdomen.

Exercise 7. Standing, hands free. The walk free - 1 min, then with high flexion of the hips - 10-20 movements with subsequent transition to a peaceful walk 1-2 minutes Breathing rhythmic, medium depth.

Exercise 8. Sitting on the edge of the chair, hands on the waist. The bowing of the back and bending forward of the body. Repeat 6-10 times. Breathing is not to delay.

Exercise 9. Sitting on the edge of the chair, the emphasis tassels on the edge of a chair, and your feet slightly in front of the chair. Squats with a focus hands on the edge of a chair - 4-6 times. When you squat exhale.

Exercise 10. Standing sideways to the back of the chair to hold it with one hand. Swing free straight arm with leg pulling back. To return to the original position. Repeat 4-6 times for each leg and arm. Breathing is not to delay.

Exercise 11. Standing, legs apart widely, hands on waist. Turns the body right and left - 6-10 times alternately. The head does not turn, to look forward.

Exercise 12. Standing, feet together, hands down. Move the hands to the sides, inhale, bend the leg at the knee and pressed his hands to his stomach exhale. 3-5 times each leg alternately. Strive to maintain balance; on the exhale, draw your abdomen

Exercise 13. Standing, feet together, hands pubescent. The side slopes of the case with flexion of the opposite hand (“pump”).

Breathing is not to delay, to strive for greater excursion of movement.

Exercise 14. Standing. A quiet walk with a uniform average depth of breathing. 1-2 minutes

Exercise 15. Lying on the Mat to put under your head with a pillow. Go to a half-sitting position and bent to hug the hips, exhale, return to the starting position and inhale. Breath hold. Strive in a semi-sitting position to maintain balance. Run 4-6 times.

Exercise 16. Lying down, arms at sides, legs apart. A semi-circular motion right straight leg to the left with the rotation of the pelvis - exhale - return to the starting position and inhale. 3-5 times in each direction. Alternately left and right, with the greatest possible excursion movement of the leg, keeping the emphasis brushes the floor.

Exercise 17. Sitting on the floor; a) to stand on all fours; b) to move into position on his knees; hands up - breath, torso, and hands to take back - exhale. When the tilt pull the stomach. Repeat 4-6 times; d) to go into a standing position, and son-in-law in the supine position; (e) self-massage of the abdomen small polukrugom movements clockwise - 1-2 minutes Rest 2 min; W) quiet breathing; C) exercise the protrusion (calm) and retraction (active) abdominal wall. Utgivare the belly combined with exhale through the mouth. Repeat 4-6 times.

Exercise 18. Standing with arms bent. Energetic walking on the spot or area of high flexion of the hips and waving of hands - 20-30 steps. Breathing is not to delay.

Exercise 19. Sitting on a chair, legs apart, hands on the waist or rest against the edge of a chair. The circular motion of the pelvis with the retraction of the abdomen when moving the pelvis back. 4-6 times in each direction.

Exercise 20. Standing. A peaceful walk with the breath of the average depth of 2-3 minutes

When the source sufficient trained or arising in the course of the practice of tolerance to physical loads, you can use the following set of exercises.

2.2. Enhanced preventive and curative gymnastics.

Exercise 1. Standing. The quiet walk with rubbing the palms of the thorax, abdomen, lower back. Runs 1-2 minutes

Exercise 2. Standing, hands down. Simultaneous bending with tension and free “throwing” hand forward, sideways and upwards of 12-16 times. When you bend exhale, when the alignment of breath.

Exercise 3. Standing, hands on waist, legs shoulder-width apart. Lateral motion of the pelvis to the right and left, back and forth. Is 6-10 times alternately. Breathe freely.

Exercise 4. Standing, feet shoulder-width apart, hands pubescent. Circular motion direct hand in the shoulder joints, 6-10 times with a maximum excursion, breathing not to hold

Exercise 5. Standing, hands in front of chest, bent at the elbows. Walking with high flexion of the hips, with a touch of the hand. 6 to 10 times for each leg alternately. Motion of energetic, hip flexion - exhale through the mouth.

Exercise 6. The quiet walk 1-2 minutes

Exercise 7. Sitting on the edge of the chair, hands on the waist. Bending and bowing of the body. The exercise is performed 8-10 times. The energetic movement. When straightening - breath, bending exhale.

Exercise 8. Standing sideways to the chair, to hold back, the other hand on the waist. Alternate sweeps straight leg forward, with the greatest possible tour. Swing legs to be combined with the exhalation. Runs 4-6 times.

Exercise 9. Standing, feet apart, hands at sides. Bending the body forward, touch right brush left toe of the feet, the other hand is allotted up. To return to the original position. Tilt combined with exhalation, by straightening the breath by 4-6 times.

Exercise 10. Walking the quiet breathing of medium depth. 1-2 minutes

Exercise 11. Standing, hands in a fist and lowered: (a) bending of the arms at the elbows with the power and extension of their diverting ago, with possibly large rectification and voltage and delay in the stress state within 2-3 C. Standing, hands on waist; b) proprietary with subsequent lifting in socks and tension legs. The exercise is performed 4-6 times with possibly large rectification and voltage, and delay in the stress state within 2-3 C.

Exercise 12. Sitting on the edge of the chair. In the raised position and bent knee leg to make alternate shaking the hands of the calf muscles and thighs. To reduce muscle tension. 1-2 minutes

Exercise 13. Sitting on the edge of the chair, straight leg divorced. Pinch open and direct the hands and feet. When breeding breath, when the note - exhale. Is 4-8 times.

Exercise 14. Standing. The quiet walk with the transition to the rhythmic quiet running (Jogging) on the spot or moving. For fatigue to go on a peaceful walk with the breath of medium depth. 2-5 minutes

Exercise 15. Lying on the Mat. Simultaneous lifting of the body and legs on the exhale. 4-6 times. Arms and legs should be straight, to keep the balance.

Exercise 16. Lying on the Mat, the emphasis brushes the floor. Cross movement straight leg - scissors. 4-8 times. Breathing is not to delay.

Exercise 17. With a quick straightening of the legs to move into a sitting position, then to lie down. You can help stroke 4-6 times.

Exercise 18. Lying on your back, legs bent. Calm breathing 4-6 times.

Exercise 19. Lying on his back, hands diluted with emphasis brushes the floor. With the rotation of the pelvis to the left, bend the legs, rotate the pelvis with legs crossed to the right and stretch the legs. To repeat such a circular motion feet 3-6 times in each direction of paperman is O. Hands not off the floor. Breathing is not to delay.

Exercise 20. Lying on your back, arms and legs separated. Alternate turns the body right and left laying one hand to the other. Feet are not slipping. When divorced hands - breath, turning exhale. Performed 3-6 times.

Exercise 21. Lying on your back, arms along the body: a) turn on your left side; b) to turn on the right side; C) switch to lying on his stomach; to kneel; d) to move in a standing position; (e) walking on the spot with high flexion of the hips and the movement of the hand - 20-30 steps; g) to sit on the Mat; C) lie on your back, relaxing breath. The whole complex repeat 3-4 times.

Exercise 22. Standing. Walking the quiet breathing of the average depth of 1-2 minutes

Exercise 23. Standing, feet apart on the width of the foot, hands on waist. Circular motion of the pelvis, right and left 6-8 times. Breathing is not to delay.

Exercise 24. Standing with legs wide apart, hands in front of chest. Alternately bending the legs with the transfer to it of gravity of the body with stretching hand to toe of the bent leg. 4-6 times in each direction. The other leg is straight. When straightening - breath, when the tilt - exhale.

Exercise 25. Standing, feet apart at shoulder width, hands on waist. Circular head movements by 4-10 times in each direction.

Exercise 26. Standing, feet apart at shoulder width, hands on the waist bend trunk to the right, pulling the left arm up - breath. Return to starting position - exhale. 4-6 times alternately.

Exercise 27. The same hands to the shoulders. Circular motion of the brushes with the maximum excursion in the shoulder joints, when breeding - breath during the mixing and retraction of the abdominal wall exhale. Breathing deep.

Exercise 28. Standing. A peaceful walk and breath the average depth. The reduction of the total load. 1-2 minutes

3. Fractional exercise during the day.

Depending on the conditions of real life patients with D you can recommend various exemplary embodiments of the fractional loads to increase physical (motor) activity during the day.

Option 1.

Exercise 1. Sitting - dilute the elbows to the sides, inhale, extend hands forward voltage exhale, 4-6 times.

Exercise 2. Sit - to stand with the deflection of the housing and land - 8-10 times.

Exercise 3. Sitting mimicking the movements of a boxer with possibly a large turn of the body is 10-12 times.

Option 2.

Exercise 1. Standing - walking with high flexion in the hip - 16-30 times.

Exercise 2. Standing - circular head movements to the right and left - 3-8 times in each direction.

Exercise 3. Standing legs apart widely imitated the movements of Costa - 10-12 times.

Exercise 4. Sitting - transition into the standing - 10-12 times.

Option 3.

Exercise 1. The quiet walk - 1 min

At ranenie 2. Walking fast - 1 minute

Exercise 3. Walking with high flexion of the hips and alternate wave of the hands 20-30 times.

Exercise 4. Walking the quiet breathing of 1-2 min; quiet running on the spot or move around the room - 2-5 minutes

Option 4.

Walk the pedestrian varying length.

Option 5.

Physical work in different ways and with different duration depending on the conditions (cleaning, home services, cleaning, gardening work, and others).

In addition to custom-made non-medical treatment of patients with AO should be administered daily swimming in the pool at least 30 minutes a day and Metformin at a dose of 850 mg 2 times a day.

The biological age of patients is determined by calculating the ratio of the number of electronegative cells to the total number of scraping buccal epithelium when conducting microelectrophoresis (Vgushakov, Allabatou, Twillweave. The method of determining the biological age of a person. Description of the invention to author's certificate SU 1169614). The obtained results are evaluated according to the reference curve (figure). The essence of this process explain the examples.

Example 1. The patient Century, 50 years, suffering from abdominal obesity for 9 years after a night of rest was taken the sample of buccal cells. P is the training of the cells, in which is pre-added to 0.5 μl of water was placed in a cell of microelectrophoresis. Included a constant voltage source, providing on the electrode chamber current of 0.1 ml, and within 5 min were observed under the microscope, by change of polarity, with the offset of cell nuclei in the electric field in five fields of view. The number of electronegative (EA) engines was 42 per 100 cells. Passport age of surveyed persons 50 years. This indicates that the result should be compared with the right branch of the reference curve to determine the biological age. Putting a value on the curve EA and projecting on the abscissa, we find the age corresponding to 59 years. This indicates that this person older than his passport age 9 years. The patient was assigned to a low-calorie diet, daily physical activity, daily swimming in the pool at least 30 minutes a day and Metformin 850 mg 2 times a day. The patient was regularly looked after the start of treatment. Simultaneously with the inspection was carried out the determination of the biological age.

After 7 weeks of treatment, the patient has decreased the severity of dyslipidemia, electronegativity nuclei of cells was 54%, testified under biological and chronological age in this patient. Ill suggest observing the th data recommendations in the following.

Example 2. Patient N., 44 years, suffering from abdominal obesity for 12 years under examination revealed that the rate electronegative nuclei, defined as in example 1 was 42%. The patient was assigned to a low-calorie diet, daily physical activity, daily swimming in the pool at least 30 minutes a day and Metformin 850 mg 2 times a day. The patient was regularly looked after the start of treatment. Simultaneously with the inspection was carried out the determination of the biological age.

After 7 weeks of treatment, the patient was reduced biological age below the calendar. The electronegativity of nuclei was 61%, which indicated that the biological age of the patient was equal to 40 years.

The patient is recommended to follow the instructions given in the following.

The use of the proposed method of correction of biological age in gerontology and endocrinology will help to avoid many complications in patients with AO, to reduce their number of cases of temporary disability, to reduce the duration of hospitalization, reduce morbidity and mortality.

The way to reduce pathologically increased biological age in patients with abdominal obesity, including the appointment of a low-calorie diet, a rational dosed static and dynamic physical Naga is narrow, daily swimming in the pool at least 30 minutes a day and the drug Metformin 850 mg 2 times a day for at least 7 weeks.



 

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FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology, cardiology and endocrinology, and concerns short-term optimisation of hyperfibrinogenemia in arterial hypertension and impaired glucose tolerance. That is ensured by the integrated treatment including graduated physical activity, daily swimming in a pool for at least 20 minutes, and introduction of metformin in dosage 500 mg 2 times a day and lisinopril in dosage 10 mg once a day at the same time in the morning for 1 month.

EFFECT: such complex drug-induced and drug-free therapy combined with empirically prescribed treatment length provides short-term normalisation of fibrinogen level and thereby reduced risk of thrombotic complications in the given group of the patients due to potentiation of therapeutic effect of separate components of an individual care.

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FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to haematology, cardiology, endocrinology and can be used for optimising the functional responsiveness of cardiovascular system (CVS) in elderly and senile arterial hypertension and type II diabetes mellitus. That is ensured by estimating the state of functional responsiveness of the CVS in psychoemotional load. And systolic, diastolic, average dynamic pressure and heart rate (HR) are recorded. These data are used to evaluate a functional responsiveness index (FRI) before and after load by formula: FRI=(BPav.dyn. × HR)/100 (standard units). The incrementing FRI more than by 20 standard units requires a therapy to be prescribed. The therapy combines daily swimming in a pool for at least 15 minutes a day, morning hygienic gymnastics, therapeutic gymnastics and graduated physical exercises throughout a day, and also administration of irbesartan 150 mg once in the morning and pioglitazone 30 mg once in the morning. The length of treatment is at least 3 weeks.

EFFECT: method allows for well-timed diagnosis of the impaired functional responsiveness of the CVS, and combination of the presented modalities ensures the effective correction, prevention of complications of arterial hypertension and type II diabetes mellitus in the case patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology, cardiology and endocrinology, and concerns decreasing endotheliocytemia in the patients with arterial hypertension and impaired glucose tolerance. That is ensured by the integrated treatment including graduated physical activity, daily swimming in a pool for at least 20 minutes, and introduction of metformin in dosage 500 mg 2 times a day and lisinopril in dosage 10 mg once a day in the morning for 1 month.

EFFECT: ensured decrease of the circulating endothelial cells in blood to the normal values and thereby reduction of risk of thrombotic complication in the case patients due to potentiation of therapeutic effect of certain components of an individual care.

1 ex

FIELD: medicine, veterinary science.

SUBSTANCE: invention refers to veterinary science. The method involves three intramuscular introduction of ferroglucin 75 mg (1 ml) every 5 days, three intramuscular introduction of phosprenyl by different syringes in different points simultaneously with an iron preparation, 0.12 ml/kg for the first injection, 0.10 ml/kg for the second injection, 0.08 ml/kg for the third injection, and the intramuscular injections of gamavit 0.018 ml/kg once a day for eight days starting with the first injection of ferroglucin.

EFFECT: method allows to prevent vascular complications in newborn calves with anaemia, to optimise microcirculation and tissue trophism, to hasten the growth, to improve a herd, to produce greater amount of meat production, to produce an expected healthy posterity from these animals.

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