Method of reducing biological age in case of arterial hypertension with abdominal obesity and dyslipidemia

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to gerontology and cardiology and can be used for reduction of pathologically increased biological age (BA) in patients with arterial hypertension (AH) with abdominal obesity (FO) and dyslipidemia. Essence of claimed method lies in the following: to patients administered is complex, that includes hypocaloric diet, calculated in kcal by formula: for women: 18-30 years old - (0.0621 × body weight, kg + 2.0357) × 240; 31-60 years old - (0.0342 × body weight, kg + 3.5377) × 240; over 60 years old - (0.0377 × body weight, kg + 2.7545) × 240; for men: 18-30 years old- (0.0630 × body weight, kg+ 2.8957) × 240; 31-60 years old - (0.0484 × body weight, kg + 3.6534) × 240; over 60 years old - (0.049 × body weight, kg + 2.4587) × 240. Also administered are rationally dosed static and dynamic physical loadings, including morning hygienic gymnastics, preventive medical gymnastics, fractional physical exercises during the day, daily swimming in swimming pool for not less than 60 minutes per day. Also introduced are medications simvastatin 10 mg 1 time before going to bed after meal and lisinopril 10 mg 1 time per day in the morning for not less than 7 weeks.

EFFECT: invention combines application of all components of complex allows to normalise BA within 7 weeks of treatment.

2 ex

 

The invention relates to medicine, namely to gerontology and cardiology.

Analogues of the proposed method of reducing biological age in patients with arterial hypertension (AH) with abdominal obesity (AO) and dyslipidemia (D) does not exist.

In the literature there are recommendations for the appointment of a balanced diet, swimming and physical exercise to delay age-related changes (Podkolzin A.A., Dontsov V.I. Aging, longevity and bioactivity, Moscow, 1996. - 144 C.) to a greater extent focused on slowing the development of age-related changes in relatively healthy people. There is also information about applying rational diet (Savelyeva L. Modern approaches to treatment of obesity. // The doctor, 2000, No. 12 - p.12-14; Kadyrov, BC, Salhanov B.A. Nutrition in obesity. Alma-ATA, Kazakhstan, 1990) or physical training (V. Moshkov. Exercise in obesity. - M.: Medicine, 1976. - 56 S.) in patients with various components of the metabolic syndrome.

For the correction of dyslipidemia used statins, and for the treatment of hypertension lisinopril.

However, never before medical complex, consisting of a low-calorie diet, dosed physical activity, swimming and drugs simvastatin and lisinopril, have not been applied in patients with AO and D to reduce their pathologically increased biological age.

The purpose of the image is the shadow is the reduction of pathologically increased biological age of patients with arterial hypertension with AO and D.

The essence of the proposed method lies in the fact that to reduce pathologically increased biological age sick AG with AO and D for a long period of time is assigned to a low-calorie diet, measured static and dynamic exercise, daily swimming in the pool at least 60 minutes a day and drugs simvastatin at a dose of 10 mg 1 time a day at night and lisinopril 10 mg 1 time in the morning.

The method allows to align biological and chronological age in patients with AO and D for 7 weeks. Subject to the subsequent recommendations of the proposed method may reduce the biological age below chronological, which will significantly improve the quality of life of patients with arterial hypertension with AO and D, to reduce their pathological burden, reduce the number of cases of temporary disability, to accelerate and improve the quality of patient treatment, to exclude disability, as well as extend the life and reduce mortality of patients with arterial hypertension with AO and D. from heart attack and stroke.

The inventive method is carried out as follows.

To create a negative energy balance in the body, patients are advised individually selected low-calorie diet.

Calorie daily diet for each individual AG with AO and D is calculated in kcal in fo the mule:

for women 18-30 years (0,0621 × body weight (kg) + 2,0357) × 240,

31-60 years (0,0342 × body weight (kg) + 3,5377) × 240,

over 60 years of age (0,0377 × body weight (kg) + 2,7545) × 240,

for men 18-30 years (0,0630 × body weight (kg) + 2,8957) × 240,

31-60 years (0,0484 × body weight (kg) + 3,6534) × 240,

over 60 years of age (0,0491 × body weight (kg) + 2,4587) × 240.

The resulting coefficient remains unchanged with minimal physical activity, multiplied by 1.3 in moderate and 1.5 - high physical activity (usually in patients with AH, AO and D physical activity level low).

It is recommended that 3 main meals and 2 intermediate. With regular skipping one meal significantly increases the incidence of obesity, also revealed a positive correlation between obesity and skipping Breakfast. It is recommended that the following distribution of daily calories: Breakfast - 25%, 2nd Breakfast - 10%, lunch - 35%, tea - 10%, dinner - 20%.

To compile menu the patient uses a special table with the instructions of the chemical composition and caloric content of products, given that the main sources of energy: protein (1 g contains 4 kcal), fat (9 kcal), carbohydrates (4 kcal) and alcohol (7 kcal).

The second component of the proposed method is feasible regular physical exercise.

In real life you can implement the three forms of physical activity: ) morning hygienic gymnastics (charging); 2) health care gymnastics; 3) fractional exercise during the day.

1. Morning hygienic gymnastics (charging).

Morning gymnastics should do after waking up to Breakfast in a ventilated room. Under the influence of training the body is released from the state of inhibition of the physiological processes taking place during sleep.

The sequence of the exercises involves the alternation of load on different muscle groups (arms, legs, body). Exercises are performed with gradually increasing excursion breathing, stretching, limited use of power conditions. Breathing exercise should be free, rhythmic, without delay, mainly through the nose; the exhalation should be longer than the inhale (breath in 2-3 sec, exhale 3-5).

In good health the load, you can increase the number of repetitions faster, increase range of motion and shorter pauses between exercises.

When fatigue should reduce the load, increase the duration of pauses between exercises, to fill their quiet breathing.

After gymnastics, you must go to the rubbing or take a shower.

Morning exercises should evoke a sense of vitality, increase activity, improve well-being and health.

When bad samochustvie and, the development of shortness of breath or pain in the heart and behind the sternum should be temporarily suspend classes and consult a doctor.

During the day, sick AG with AO and D is the recommended treatment and preventive exercises. Depending on the initial fitness may use first lightweight option, physical activity, and subsequently enhanced option.

2. Complexes of preventive and curative gymnastics for persons suffering from hypertension, AO and D.

2.1. The lightweight version of preventive and curative gymnastics.

Exercise 1. Standing. A quiet walk with a gradual acceleration and deceleration 1-2 minutes on the exercise of the gradual deepening of the breath.

Exercise 2. Circular motion in the shoulder joints. When breeding breath, when the note - exhale with a slight tilt of the torso and retraction of the abdominal wall 6-8 times. The fingers touch the shoulders, elbows close to the torso.

Exercise 3. Standing, hands on his belt. Alternately shifting the weight of the body from one foot to the other with a small bending the legs at the knee joint without lifting the feet from the floor. Exercise done 10-16 times with the muscles of the legs.

Exercise 4. Standing, feet apart at shoulder width, hands on his belt. Bending the trunk forward, touch right hand to left toe. 4-6 times alternately. When straightened position - inhale, tilt the exhale. To look ahead.

At ranenie 5. Standing with arms along the body. At the same time to take straight arm and one leg to the side with alternating lead leg. 4-6 times in each direction in turn. A wave of the hands and feet, breathe freely, do not delay.

Exercise 6. Standing, feet apart, hands in front of chest with palms down. With a turn of the body to dissolve hand in hand with turning the palms up - breath. To return to the original position with a small tilting forward, exhale. 3-5 times in each direction in turn. Breathing to harmonize with the movement of hands and body. By the end of exhalation to engage the wall of the abdomen.

Exercise 7. Standing, hands free. The walk free 1 min, then with high flexion of the hips 10-20 movements with subsequent transition to a peaceful walk 1-2 minutes Breathing rhythmic, medium depth.

Exercise 8. Sitting on the edge of the chair, hands on the waist. The bowing of the back and bending forward of the body. Repeat 6-10 times. Breathing is not to delay.

Exercise 9. Sitting on the edge of the chair, the emphasis tassels on the edge of a chair, and your feet slightly in front of the chair. Squats with a focus hands on the edge of a chair 4-6 times. When you squat exhale.

Exercise 10. Standing sideways to the back of the chair to hold it with one hand. Swing free straight arm with leg pulling back. To return to the original position. Repeat 4-6 times for each leg and arm. Breathing is not to delay.

Exercise 11. Standing, feet apart Shire is to, hands on waist. Turns the body right and left 6-10 times alternately. The head does not turn, to look forward.

Exercise 12. Standing, feet together, hands down. Move the hands to the sides, inhale, bend the leg at the knee and pressed his hands to his stomach exhale. 3-5 times each leg alternately. Strive to maintain balance; on the exhale, draw your abdomen.

Exercise 13. Standing, feet together, hands pubescent. The side slopes of the case with flexion of the opposite hand ("pump"). Breathing is not to delay, to strive for greater excursion of movement.

Exercise 14. Standing. The walk is quiet with a steady breath average depth of 1-2 minutes

Exercise 15. Lying on the Mat to put under your head with a pillow. Go to a half-sitting position and bent to hug the hips, exhale, return to the starting position and inhale. Breath hold. Strive in a semi-sitting position to maintain balance. Run 4-6 times.

Exercise 16. Lying down, arms at sides, legs apart. A semi-circular motion right straight leg to the left with the rotation of the pelvis - exhale, return to the starting position and inhale. 3-5 times in each direction. Alternately left and right, with the greatest possible excursion movement of the leg, keeping the emphasis brushes the floor.

Exercise 17. Sitting on the floor to stand on all fours; b) to move into position on his knees; hands up - inhale, tilt tolove is e, and the hands to take back - exhale. When the tilt pull the stomach. Repeat 4-6 times; d) to go into a standing position, and then in the supine position; (e) self-massage of the abdomen small polukrugom movements clockwise - 1-2 minutes Rest 2 min; W) quiet breathing; C) exercise the protrusion (calm) and retraction (active) abdominal wall. The retraction of the abdomen combined with exhale through the mouth. Repeat 4-6 times.

Exercise 18. Standing with arms bent. Energetic walking on the spot or area of high flexion of the hips and waving of hands - 20-30 steps. Breathing is not to delay.

Exercise 19. Sitting on a chair, legs apart, hands on the waist or rest against the edge of a chair. The circular motion of the pelvis with the retraction of the abdomen when moving the pelvis back. 4-6 times in each direction.

Exercise 20. Standing. A peaceful walk with the breath of the average depth of 2-3 minutes

When the source sufficient trained or arising in the course of the practice of tolerance to physical loads, you can use the following set of exercises.

2.2. Enhanced preventive and curative gymnastics.

Exercise 1. Standing. The quiet walk with rubbing the palms of the thorax, abdomen, lower back. Runs 1-2 minutes

Exercise 2. Standing, hands down. Simultaneous bending with tension and free "throwing" hand forward, sideways and upwards of 12-16 times. When STP is assured - exhale, when the alignment of breath.

Exercise 3. Standing, hands on waist, legs shoulder-width apart. Lateral motion of the pelvis to the right and left, back and forth. Is 6-10 times alternately. Breathe freely.

Exercise 4. Standing, feet shoulder-width apart, hands pubescent. Circular motion direct hand in the shoulder joints, 6-10 times with a maximum excursion, breathing, do not delay.

Exercise 5. Standing, hands in front of chest, bent at the elbows. Walking with high flexion of the hips, with a touch of the hand. 6 -10 times for each leg alternately. Motion of energetic, hip flexion - exhale through the mouth.

Exercise 6. The quiet walk 1-2 minutes

Exercise 7. Sitting on the edge of the chair, hands on the waist. Bending and bowing of the body. The exercise is performed 8-10 times. The energetic movement. When straightening - breath, bending exhale.

Exercise 8. Standing sideways to the chair, to hold back, the other hand on the waist. Alternate sweeps straight leg forward, with the greatest possible tour. Swing legs to be combined with the exhalation. Runs 4-6 times.

Exercise 9. Standing, feet apart, hands at sides. Bending the body forward, touch right brush left toe of the feet, the other hand is allotted up. To return to the original position. Tilt combined with exhalation, by straightening the breath by 4-6 times.

Exercise 10. Walking the quiet breathing of the average depth of 1-2 minutes

pragnienie 11. Standing, hands in a fist and lowered: (a) bending of the arms at the elbows with the power and extension of their diverting ago, with possibly large rectification and voltage and delay in the stress state within 2-3 C. Standing, hands on waist: b) proprietary with subsequent lifting in socks and tension legs. The exercise is performed 4-6 times with possibly large rectification and voltage and delay in the stress state within 2-3 C.

Exercise 12. Sitting on the edge of the chair. In the raised position and bent knee leg to make alternate shaking the hands of the calf muscles and thighs. Reduce muscle tension 1-2 minutes

Exercise 13. Sitting on the edge of the chair, straight leg divorced. Pinch open and direct the hands and feet. When breeding breath, when the note - exhale. Is 4-8 times.

Exercise 14. Standing. The quiet walk with the transition to the rhythmic quiet running (Jogging) on the spot or moving. For fatigue to go on a peaceful walk with the breath of medium depth. 2-5 minutes

Exercise 15. Lying on the Mat. Simultaneous lifting of the body and legs on the exhale 4-6 times. Arms and legs should be straight, to keep the balance.

Exercise 16. Lying on the Mat, the emphasis brushes the floor. Cross movement straight leg - scissors 4-8 times. Breathing is not to delay.

Exercise 17. With a quick straightening of the legs to move into a sitting position, for the eat to go. You can help stroke 4-6 times.

Exercise 18. Lying on your back, legs bent. Calm breathing 4-6 times.

Exercise 19. Lying on his back, hands diluted with emphasis brushes the floor. With the rotation of the pelvis to the left, bend the legs, rotate the pelvis with legs crossed to the right and stretch the legs. To repeat such a circular motion feet 3-6 times in each direction alternately. Hands not off the floor. Breathing is not to delay.

Exercise 20. Lying on your back, arms and legs separated. Alternate turns the body right and left laying one hand to the other. Feet are not slipping. When divorced hands breath, turning exhale. Performed 3-6 times.

Exercise 21. Lying on your back, arms along the body: a) turn on your left side; b) to turn on the right side; C) switch to lying on his stomach; to kneel; d) to move in a standing position; (e) walking on the spot with high flexion of the hips and the movement of the hand - 20-30 steps; g) to sit on the Mat; C) lie on your back, relaxing breath. The whole complex repeat 3-4 times.

Exercise 22. Standing. Walking the quiet breathing of the average depth of 1-2 minutes

Exercise 23. Standing, feet apart on the width of the foot, hands on waist. Circular motion of the pelvis, right and left 6-8 times. Breathing is not to delay.

Exercise 24. Standing with legs wide apart, hands in front of chest. Alternately bending the legs with the Perrin is senjem on her the gravity of the body with stretching hand to toe of the bent leg. 4-6 times in each direction. The other leg is straight. By straightening the breath, when the tilt - exhale.

Exercise 25. Standing, feet apart at shoulder width, hands on waist. Circular head movements by 4-10 times in each direction.

Exercise 26. Standing, feet apart at shoulder width, hands on waist. Bend trunk to the right, pulling the left arm up - breath. Return to starting position - exhale. 4-6 times alternately.

Exercise 27. The same hands to the shoulders. Circular motion of the brushes with the maximum excursion in the shoulder joints, when breeding breath during the mixing and retraction of the abdominal wall exhale. Breathing deep.

Exercise 28. Standing. A peaceful walk and breath the average depth. The reduction of the total load. 1-2 minutes

3. Fractional exercise during the day.

Depending on the conditions of real life in patients with AH, AO and D can be recommended to various exemplary embodiments of the fractional loads to increase physical (motor) activity during the day.

Option 1.

Exercise 1. Sitting - dilute the elbows to the sides, inhale, extend hands forward voltage exhale, 4-6 times.

Exercise 2. Sitting - up with deflection of the hull and take 8-10 times.

Exercise 3. Sitting mimicking the movements of a boxer with possibly a large turn of the body 10-12 times.

Option 2.

Exercise 1. Standing - walking with high shibani the m hips 16-30 times.

Exercise 2. Standing - circular head movements to the right and left by 3-8 times in each direction.

Exercise 3. Standing legs apart widely imitated the movements of Costa 10-12 times.

Exercise 4. Sitting - goto standing 10-12 times.

Option 3.

Exercise 1. The quiet walk - 1 min

Exercise 2. Walking fast - 1 minute

Exercise 3. Walking with high flexion of the hips and alternate wave of the hands 20-30 times.

Exercise 4. Walking the quiet breathing of 1-2 min; quiet running on the spot or move around the room 2-5 minutes

Option 4.

Walk the pedestrian varying length.

Option 5.

Physical work in different ways and with different duration depending on the conditions (cleaning, home services, cleaning, gardening work, and others).

In addition to custom-made non-medical treatment of sick AG with AO and D should be administered daily swimming in the pool at least 60 minutes per day simvastatin at a dose of 10 mg 1 time a day at night and lisinopril 10 mg 1 time in the morning.

The biological age of patients is determined by calculating the ratio of the number of electronegative cells to the total number of scraping buccal epithelium when conducting microelectrophoresis (Vgushakov, Allabatou, Twillweave. The method of determining the biologist is centred on a person's age. Description of the invention to author's certificate SU 1169614). The obtained results were evaluated on the reference curve. The essence of this process explain the examples.

Example 1. Patient L., 54 years old, suffering from hypertension, AO and D (total cholesterol 6.3 mmol/l, low-density lipoproteins of 3.96 mmol/l, triglycerides 2.8 mmol/l, very low density lipoprotein of 1.27 mmol/l, high-density lipoprotein 1.07 mmol/l) for 7 years after a night of rest was taken the sample of buccal cells. A sample of cells, which have previously added to 0.5 μl of water was placed in a cell of microelectrophoresis. Included a constant voltage source, providing on the electrode chamber current of 0.1 ml, and within 5 min were observed under the microscope, by change of polarity, with the offset of cell nuclei in the electric field in five fields of view. The number of electronegative (EA) engines amounted to 30 per 100 cells. Passport age examinee 54 years. This indicates that the result should be compared with the right branch of the reference curve to determine the biological age. Putting a value on the curve EA and projecting on the abscissa, find age appropriate 69 years. This indicates that this person older than his passport age of 15 years. The patient had been assigned was hypochlo the applications diet, the system of daily physical activity, daily swimming in the pool at least 60 minutes per day, simvastatin 10 mg 1 time at night and lisinopril 10 mg 1 time in the morning. The patient was regularly looked after the start of treatment. Simultaneously with the inspection was carried out the determination of the biological age.

After 7 weeks of treatment, the patient has decreased the severity of dyslipidemia (total cholesterol 5.8 mmol/l, low-density lipoproteins of 3.53 mmol/l, triglycerides 2.5 mmol/l, very low density lipoprotein to 1.14 mmol/l, high-density lipoprotein 1.13 mmol/l), the electronegativity of the nuclei of cells was 50%, testified under biological and chronological age in this patient. The patient is asked to comply with these recommendations in future.

Example 2. Patient P., aged 40, suffering AH, AO and D (total cholesterol 6.6 mmol/l, low-density lipoprotein 4,06 mmol/l, triglycerides 3.2 mmol/l, very low density lipoprotein 1,45 mmol/l, high-density lipoprotein 1,09 mmol/l) for 5 years under examination revealed that the rate electronegative nuclei, defined as in example 1 was 46%. The patient was assigned to a low-calorie diet, daily physical activity, daily swimming in the pool at least 60 minutes per day, simvastatin 10 mg 1 time per night, Lisino the reel 10 mg 1 time in the morning. The patient was regularly looked after the start of treatment. Simultaneously with the inspection was carried out the determination of the biological age.

After 7 weeks of treatment, the patient improved blood lipid profile (total cholesterol 5.7 mmol/l, low-density lipoprotein 3.4 mmol/l, triglycerides 2.6 mmol/l, very low density lipoprotein 1.18 mmol/l, high-density lipoprotein 1.12 mmol/l), there was a decrease in biological age below the calendar. The electronegativity of nuclei was 63%, which indicated that the biological age of the patient was equal to 39 years.

The patient is recommended to follow the instructions given in the following.

The use of the proposed method of correction of biological age in gerontology and cardiology will help to avoid many complications in patients with AH, AO and D, to reduce their number of cases of temporary disability, to reduce the duration of hospitalization, reduce morbidity and mortality.

The way to reduce pathologically increased biological age in patients with arterial hypertension, abdominal obesity and dyslipidemia, including the appointment of a low-calorie diet, calculated in kcal by the formula:
for women: 18-30 years of age (0,0621 · weight, kg + 2,0357) · 240; 31-60 years (0,0342 · weight, kg + 3,5377) · 240; older than 60 years (0,0377 · weight, kg + 2,7545) · 240;
DL the men: 18-30 years (0,0630 · weight, kg + 2,8957) · 240; 31-60 years (0,0484 · weight, kg + 3,6534) · 240; older than 60 years (0,049 · weight, kg + 2,4587) · 240,
rational dosed static and dynamic physical loads, which includes morning hygienic gymnastics, therapeutic gymnastics, fractional exercise during the day, a daily swim in the pool at least 60 minutes per day and drugs simvastatin 10 mg 1 time at night after eating and lisinopril 10 mg 1 time a day for at least 7 weeks.



 

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1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to cardiology, endocrinology, and can be used for normalising the blood plasminogen activator inhibitor concentration in arterial hypertension and impaired glucose tolerance. That is ensured by graduated physical activities, daily swimming in a pool for at least 20 minutes a day, and also prescribed metformin 500 mg twice a day and lisinopril 10 mg once a day in the morning. The therapeutic course is 1 months.

EFFECT: offered combination of therapeutic modalities enables normalising the blood plasminogen activator inhibitor in a relatively short time that promotes prevention thrombotic complications in the case patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to gerontology and cardiology, and concerns biological age reduction in arterial hypertension combined with abdominal obesity. That is ensured by the integrated treatment including a low-calorie diet, reasonable graduated static and dynamic physical activity, daily swimming in a pool for at least 30 minutes, and the introduction of lisinopril in dosage 10 mg once a day in the morning and metformin in dosage 500 mg twice a day for the therapeutic course of 7 weeks.

EFFECT: complex of drug-induced and drug-free therapy combined with empirically prescribed treatment length provides biological age reduction in the case patients estimated by the relation of electronegative cells to total count in a buccal epithelium scrape due to normalised DNA repair and chromosome fragility level.

2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to compounds of formula Ia and their pharmaceutically acceptable salts, hydrates, solvates, esters and amides. In formula Ia , A is specified from -C(O)OR5 where R5 represents hydrogen; W represents C1-3alkylene; Y is specified from phenyl and 5-6-member heteroaryl containing one heteroatom specified from N, S, O; where any phenyl or heteroaryl Y can be optionally substituted with 1 to 3 radicals specified from halogen, C1-6alkyl, C1-6alkoxygroup, halogen-substituted C1-6alkyl and halogen-substituted C1-6alkoxygroup; Z is specified from: where left and right asterisks Z specify an attachment point between -C(R3)(R4)- and A of formula la; R6 is specified from hydrogen and C1-6alkyl; or R6 can be attached to carbon atom in Y to form a 5-7-member ring; R1 is specified from phenyl and 5-member heteroaryl containing one heteroatom specified from S, O; where any phenyl or heteroaryl R1 is substituted with a radical specified from phenylC0-4alkyl, heteroarylC0-4alkyl where heteroaryl represents 5-6-member heteroary containing one heteroatom specified from N, S, O, C3-8cycloalkylC0-4alkyl, C3-8heterocycloalkylC0-4alkyl which contains nitrogen atom as heteroatom, or C1-6alkyl; where any phenyl, heteroaryl, cycloalkyl or heterocycloalkyl group R1 can be optionally substituted with 1 to 3 radicals specified from halogen, C1-6alkyl, C1-6alkoxygroup, halogen-substituted C1-6alkyl group and halogen-substituted C1-6alkoxygroup; R2 represents C1-6alkyl group; R3 and R4 represent hydrogen.

EFFECT: preparation of the pharmaceutical composition exhibiting EDG/S1P receptor modulating properties, containing therapeutically effective amount of the compound under the invention, development of a method of treating the disease mediated by EDG/S1P receptor activity, application of the compounds for preparing a drug for prevention or treatment of the disease mediated by EDG/S1P receptor activity.

16 cl, 1 tbl, 86 ex

FIELD: medicine.

SUBSTANCE: invention belongs to medicine, notably, to gerontology, cardiology and can be used for pathologically raised biologic age in patients with arterial hypertension. To achieve this, rationally dosed static and dynamic physical exercises are administered, daily swimming in swimming pool at least 30 minutes daily and 10 mg of lisinopril daily in the morning. Course of treatment is 7 weeks.

EFFECT: combination of treatment methods ensures equalisation of biologic and chronologic ages, thus improving quality of life in this group of patients.

2 ex, 1 dwg

FIELD: medicine.

SUBSTANCE: invention belongs to medicine, notably to haematology and cardiology and refers to reduction of spontaneous erythrocytes aggregation in patients with arterial hypertension. This is ensured by the integrated treatment including graduated static and dynamic physical loads, including daily swimming for at least 20 minutes in the middle of the day, daily, and administration of lisinopril 10 mg once a day in the morning and amlodipine 10 mg once a day in the morning.

EFFECT: combined drug-free and drug therapies during empirically fitted period ensure effective reduction of spontaneous aggregation of erythrocytes, which, in turn, allows to improve blood's rheological properties and reduce risk of thrombotic complications in patients with arterial hypertension.

2 ex

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine, in particular to ophthalmology, and may be intended for treatment of hemodynamics abnormalities in visual nerve vessels in case of their atherosclerotic lesion. Medical therapy is administered with established treatment regimen. At the same time lipid spectrum of blood plasma is investigated, and if level of total cholesterol is more than 5.1 mmole/l, treatment with pentoxifylline in tablet form, 0.2 g 3 times a day after food intake, piracetam in pills, 40 mg 3 times a day before food intake, simvastatin, 10 mg per day, in tablet form, once, in the evening time, treatment is administered for 6 months. Afterwards hemodynamic indices are investigated by means of ultrasound Doppler sonography.

EFFECT: improved blood circulation in vessels of carotid system and regional vessels of visual nerve.

3 tbl, 1 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to haematology, and may be used to normalise aggregative activity of platelets (AAP) in patients with arterial hypertension (AH) and impaired glucose intolerance (IGI). Method includes graduated physical loads such as morning hygienic exercise, therapeutic exercises and split physical exercise over the day, and also introduction of metformin 500 mg, 2 times a day, and lisinopril, 10 mg once in the morning for at least a month.

EFFECT: combined application of all components of the complex makes it possible to reduce risk of thrombotic complications as a result of AAP normalisation in AH patients with IGI, changing it to the level close to such for healthy people during 1 month.

1 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to hematology and cardiology and can be applied for reduction of spontaneous aggregation of erythrocytes (SAE) in case of stable stenocardia of I-II functional class (SS I-II FC) and arterial hypertension (AH). Substance of clamed method consists in the following: 2 month-long complex of hypolipodemic diet, dosed static and dynamic physical activities, which include morning hygienic gymnastics, medical-preventive gymnastics, separate physical activities during the day, daily swimming for not less than 30 min. per day in the middle of the day, intake of lisinopril in dose 10 mg 1 time per day in the morning and simvastatine 20 mg 1 time per day after meal.

EFFECT: combined application of all components allows normalising of SAE of patients with SS of I-II functional class and arterial hypertension due to exponentiation of their medical action during 2 months of treatment.

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