Method of restoring obturative apparatus of rectum
SUBSTANCE: invention relates to medicine, in particular to proctology, and deals with correction of pelvic floor pathology, conditioned by congenital insufficiency of injury of muscular structures of obturative apparatus of rectum. For this purpose cell mass of autologous bone marrow punctate is introduced in injection form into soft tissues of paa-anal area and around rectum. Then after each introduction said areas are subjected to impact of bipolar symmetric fluctuating current, one electrode being placed on lumbar spine, the other - in region of anus. Current force is gradually increased to 5-10 mA until noticeable muscle contraction appears. Course consists of 10 daily procedures.
EFFECT: in short terms method ensures recovery of obturative apparatus of rectum similar to natural, is low-traumatic and simple in application.
The invention relates to medicine, in particular to the correction of the pathology of the pelvic floor due to congenital deficiency or damage of the muscle structures of the locking device.
A known way to provide intestinal support, including installation within the scope of the intestine of the implant, made in the form of a longitudinal cut of a porous-permeable cylindrical sleeve from a super-elastic Nickel-titanium (U.S. Pat. application No. 99124445, CL A61F 5/00, 1999).
The disadvantage of this method is its limited capacity, due to the fact that the means used do not provide effective holding like a natural.
Closest to the present invention is a method of restoring the locking apparatus of the rectum, including the introduction of the graft in prianalnoy region (U.S. Pat. Of the Russian Federation No. 2194457, CL A61B 17/00, 20.12.2002)
This method includes setting the scope of the intestine of the implant, made of super-elastic Nickel-titanium, in the form of a cylindrical laminated sleeve. The intestine send down in the crotch and fixed to promontorium form anorectal and rectosigmoidal curves and set them in a cascade three implant.
The disadvantage of this method is the increased trauma caused by surgery in the field of neural devices is and rectum with a high probability of damage. In addition, the possibility of rejection entered a foreign body, causing a number of postoperative complications.
In accordance with this task, aimed at creating simple, low-impact way for the restoration of locking apparatus of the rectum, like the natural, which will create a satisfactory socio-psychological state of the patient, increase the comfort of his life.
To solve this problem in the method of restoring the locking apparatus of the rectum, including the introduction of the graft in prianalnoy area proposed as a graft to use cell mass autologous bone marrow punctate, you need to repeatedly enter the injectable soft tissue prianalnoy the area around the rectum, then after each injection to affect this region of the bipolar symmetric flucturion shock, with one electrode placed on the lumbar spine, and the second in the anus, the current strength gradually increase to 5-10 mA before the appearance of visible muscle contraction. This treatment should consist of 10 daily procedures.
The mechanism of action of cell autograft is associated with the known ability of stem, mesenchymal, and other immature cells show prolif the operational activity in the direction of the damaged tissue or tissue demanded by the body (in this case, the striated anal sphincter muscles).
When stem cell transplantation is necessary to connect an external effects for the formation of a feedback system.
Because muscle cells being interconnected with nervous apparatus, the formation of functional connections with the Central nervous system occurs under the influence of electric pulsation when working muscle tissue. In this regard, a further necessary condition for the development of sphincter and restore its function is the stimulation of the anal region. Given that each patient has a pulse frequency strictly individual proposed to realize the impact of bipolar symmetric flucturion current, which represents the randomly varying electrical impulses that may lead to the individual resonance frequency of the patient and will speed up the formation of muscle tissue from stem cells.
The method is implemented as follows.
After admission of the patient in the hospital it is examined by the diagnostic apparatus "Chronos" and define the zones of functional disorders. In addition, identify indicators of blood flow and the oxygen content in the blood using laser spectrophotometry. In the detection of pathology of the muscular structures kapitalnogo apparatus ASU is estlat the treatment by the proposed method. What the patient taking bone marrow by bone marrow puncture in the region of the iliac crest. The number of selected punctate is 40-60 ml Selected bone punctate centrifuged to separate cell mass from the whey. Then produce autologous cell mass by subcutaneous infiltration of soft tissue prianalnoy the area around the rectum. The amount of cell mass, intended for transplantation must be in the range of 10-50 ml depending on the patient's age. With the introduction of cell mass is carried out in 2-6 techniques with a break. Then after each introduction of cell mass on the affected area shall effect bipolar symmetric flucturion current with the same frequency and amplitude. When one electrode is placed on the lumbar spine, the second in the anus. The current strength is gradually increased up to 5-10 mA before the appearance of visible muscle contraction. The duration of the treatment 10 min, in the course of 10 daily procedures. The first results usually appear within 2-4 weeks. The patient notes the occurrence of a certain sensation in the anus, improving its tone. Reduced clomazone. Then there are non-existent previously weak urge to have a bowel movement and the ability to delay defecation nokorode time. These signs start working muscular anal area gradually increase. On electromyography recorded increase in the background activity of the muscles in 1,5-2,5 times. Clearly arbitrary increases muscle activity in patients in varying degrees.
Specific examples of the method
Patient Murashov I., 16, East. Disease No. 18878.
Born with a VLOOKUP with high atresia of anus and rectum, for which in the first days of life imposed by transversostomas. Subsequently disappeared from sight for 12 years as outpatients was not observed, hospitalizations was not. In 2004 performed abdomino-perineal and zadnekamernye anorectoplasty on singing. In the postoperative period occurred stenotic disease of NEOBUS. In 2005 he was hospitalized for dilations (bougie until 16-17) on the background of weak muscles of the anus. Enrolled in a planned manner with a diagnosis of insolvency of the anus (the gaping anus, permanent clomazone).
If biografii identified: marked reduction of background and arbitrary bioelectric activity of the anal sphincter, the reflex activity of the sphincter is sharply reduced. Reflexogenic: marked venous congestion in the anal area, reducing elektrovojvodina muscle sacral area, their partial connective tissue degeneration.
The child spent treatment is their proposed method, when this cell mass autologous bone marrow punctate twice with a break in 2 days was administered by injection into soft tissue prianalnoy the area around the rectum, then after each injection impacted this area of the bipolar symmetric flucturion shock. One electrode was placed on the lumbar spine, and the second in the anus, the strength of the current was gradually increased up to 5-10 mA before the appearance of visible muscle contraction. The course of treatment was 10 daily procedures.
On the background of complex therapy Per rectum: the rectum is not gaping, appeared weak voluntary contraction of the muscles of the anus, is able to briefly hold the liquid in the ampoule rectum. According to the control myographic studies background and arbitrary bioelectric activity of the muscles of the anus increased (background with 6,63 µv to 7.10 MACs arbitrary 27, 8 µv to 34, 6 µv).
Patient Zyryanov And, 10 years No. 2851, No. 18878 born with VLOOKUP: atresia of anus and rectum with rectvisible fistula. At the age of 4 years under the guise of salmostoma child performed anorectoplasty by Rizzoli. Subsequently, constant clomazone. The girl was treated by the proposed method. When this cell mass autologous bone marrow punctate three times with an interval of two days was administered by injection into soft tissues PA is analnoe the area around the rectum, then after each injection impacted this area of the bipolar symmetric flucturion shock. The course of treatment is 10 daily procedures. The patient also received complex myostimulating therapy.
Against this background, locking activity anal machine has improved, as evidenced by the decrease in the degree of clomazone and EMG studies: background cf. - 11,23 µv, after of 13.27 MACs arbitrary cf. - 26,18 µv, after 30,33.
Sick Perevodchik D., 3rd year, No. 16193 born with multiple birth defects: atresia of anus and rectum, esophageal atresia, multicasts right kidney, obstructive megaureter left kidney. In the first days of life is made of plastic esophagus, colostomy, at the age of 2 years had anorectoplasty and antireflux surgery. Later stenotic disease of NEOBUS, incontinence of feces. The treatment in this way. When this cell mass autologous bone marrow punctate three were introduced by injection into soft tissue prianalnoy the area around the rectum, then after each injection impacted this area of the bipolar symmetric flucturion shock. Against this background, the clinical improvement. EMG: background average - 16,19 µv, after 18,7 MACs arbitrary bioelectric activity not assessed because of the age of the child.
Use on the frame of way in a short time will ensure the restoration of the locking apparatus of the rectum like a natural, that will increase the comfort of the patient's life.
The method of restoring the locking apparatus of the rectum, including the introduction of the graft in prianalnoy region, characterized in that the graft used-cell mass autologous bone marrow punctate, which is repeatedly injected into the injection into soft tissue prianalnoy area around the rectum, then after each injection affect this region of the bipolar symmetric flucturion current, one electrode is placed on the lumbar spine, and the second in the anus, current is gradually increased up to 5-10 mA before the appearance of visible muscle contraction, while the course of treatment is 10 daily procedures.
SUBSTANCE: invention relates to medicine, namely to dermatocosmetology and can be used for face and neck skin rejuvenation in women. For this purpose plasmapheresis in mode of discontinuous flow separation with sampling of 800-1000 ml of blood is carried out. In course of carrying out plasmapheresis after the first cycle, native plasma is taken and immediately introduced intradermally papularly on Langer lines. Diametre of papules is 0.5-1 cm, distance between them is 1.5-2.5 cm. Total volume of introduced plasma is 5-10 ml. Course consists of 2-3 procedures after 12-16 days.
EFFECT: method allows to increase efficiency of face and neck skin rejuvenation in women due to combination of local and systemic impact of plasma, which possesses high tropism to skin cells, which ensures formation of new collagen in skin.
3 tbl, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to chemical-pharmaceutical industry, namely to plant-based medications for intensification and prolongation of sensations during orgasm in women and men. Intimate moisturising oil contains oils of borage (Borago officinalis), oenothera (Oenothera Biennnis), garden Angelica (Angelica Archangelica) and common thyme (Thymus Vulgaris), as well as vitamin E (Tocopherol Acetate) and ascorbyl palmitate (Ascorbyl Palmitate). Stimulates orgasm in women who have difficulties with its achieving. Can be applied as lubricating means, favours increase of secretion discharge.
EFFECT: action of each component constituting composition supplement and amplify each other, due to which important properties of composition are achieved, consisting in intensification and prolongation of sensations during orgasm in men and women.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to pharmaceutical industry, in particular to hepatoprotective medication. Medication, which has hepatoprotective action, represents product of extraction by ethanol of thalli of Cha-Kombu - Laminaria japonica Aresch., of laminarian family -Laminariaceae, which contains to 30 % of polyphenol compounds.
EFFECT: medication possesses efficient hepatoprotective action, favours accelerated restoration of metabolic reactions cascade, ensuring normalisation of biochemical characteristics of carbon and lipid exchange, as well as endogenous antioxidant protection system.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention belongs to pharmaceutical industry, notably to preparation for treatment of pyelonephritis and glomerulonephritis. Organopreparation for treatment of pyelonephritis and glomerulonephritis is obtained by mixing aqueous infusions of knotgrass and orthosiphon, ascorbic and sorbic acids and pulverised dried kidneys of calves, taken in specified ratio.
EFFECT: remedy shortens time of pyelonephritis and glomerulonephritis treatment.
SUBSTANCE: invention belongs to medicine, notably to oncology, and can be used in prevention and treatment of enteropathy due to intensive cytostatic polychemotherapy. To achieve this Enterosgel (Methylsiliconic acid hydrogel) is administered during whole course of polychemotherapy and after it. After cytostatic treatment during Enterosgel administration additionally nonabsorbable enteral antiseptic ersefuril is administered. normobiotics - Hylac-forte and Primadophilus™ Bifidus are administered when level of leukocytes in blood gets higher then 1000/mcl.
EFFECT: method ensures prevention of necrotic processes, reparation of gastro-intestinal mucous lining and fast arresting of enteropathy due to toxic metabolites enterosorption, elimination of pathogenic and opportunistic microbes and regulation of intestinal flora balance.
SUBSTANCE: invention belongs to medicine, it is ointment for thermal injury treatment and is based on lard; it includes biologically active component and features with visceral fat and dihydroquercetin as biologically active component; ointment's components are in special mass percent ratio; also thermal injury method by application of ointment of abovementioned composition.
EFFECT: invention provides prevention of coarse eschars and cicatrices development due to acceleration of upper epithelial layers development and simultaneous retardation of younger granulation tissue proliferation.
4 cl, 3 ex
SUBSTANCE: invention relates to ophthalmology. Method includes application on intermarginal edge of both closed eyes of medicinal composition. Composition consists of 2.0 g of gel "Lamifaren" and 0.2 ml of 30% sodium thiosulphate. After that attachments "Rubin" to apparatus "АМО-АТОС" are tightly pressed to edges of eye socket in laser glasses in rubber rim. After that low-frequency infrared laser radiation of intermarginal edge of eyelids is performed with wavelength 650 nm, power 2.5 W. On the first day of treatment, exposure is performed with modulation frequency 1 Hz. On each of the following days frequency of exposure is increase on 1 Hz daily, maximally to 6 Hz on the fifth day of treatment. In the following 10 days of treatment exposure is performed with modulation frequency 6 Hz. Duration of procedure is increased from 3 minutes- on the first day of treatment - to 7 minutes - by the 5-th day of treatment. The following 10 sessions of procedure are carried out for 7 minutes. Total number of sessions is 15.
EFFECT: method reduces treatment terms due to increase of tissue barrier permeability for applied medications, increases duration of remission.
2 ex, 1 tbl
SUBSTANCE: invention relates to medicine, namely to neurosurgery and orthopedics, and can be used in surgery on lumbar intervertebral disks. For this purpose degenerative pulpous nucleus is ablated. After that sanitation of operated intervertebral disc is carried out by irrigation of remaining in region of surgery free fragments and non-ablated part of degeneratively altered disk with chondrolytic enzyme.
EFFECT: method allows to prevent recurrence of pain syndrome resulting from re-compression of root of spinal cord due to ablation of all without exception fragments of altered intervertebral disk by means of enzyme.
1 dwg, 1 ex
SUBSTANCE: invention refers to nanocrystalline compounds of formula (I) AOx-(L-Men+)i where AOx represents metal oxide where A it specified from Ti or Zr, x=2; Men+ represents metal ion exhibiting antibacterial activity, specified from Ag+ and Cu++, where n=1 or 2; L represents a bifunctional molecule, or a organic or metal-organic molecule able to get bound with metal oxide and ion metal Men+ simultaneously; where the organic molecule is specified from pyridine, dipyridyl, tripyridyl, functionalized with carboxylic groups (-COOH), boronic groups (-B(OH)2), or phosphonic groups (-PO3H2), or 4-mercaptophenylboronic acids; where the metal-organic molecule represents a metal-organic complex containing organic ligand coordinated with central metal atom and containing boronic (-B(OH)2), phosphonic (-PO3H2) or carboxylic (-COOH) functional group, and the groups are coordinated with central metal atom and able to get bound with metal ions with antibacterial activity; where specified organic ligand coordinated with central metal atom is specified from pyridine, dipyridyl, tripyridyl functionalized with carboxylic groups (-COOH), boronic groups (-B(OH)2), or phosphonic groups (-PO3H2), or 4-mercaptophenylboronic acids; i represents a number of groups L-Men+ bound with nanoparticle AOx. Also, there are offered a composition exhibiting antibacterial and/or antiviral activity, dermatological compositions, application of nanocrystalline compounds, a method of nanocrystalline compounds regeneration.
EFFECT: nanocrystalline compounds show effective antibacterial action.
27 cl, 4 tbl, 4 dwg
SUBSTANCE: invention refers to a compound of formula I where A represents an optionally substituted aryl or heteroaryl, B - a benzene or thiophene cycle, C - a benzene or aliphatic hydrocarbon cycle, while values of other radicals are disclosed in the description. The compound according to the present invention, and the based pharmaceutical compositions exhibit a strong antagonistic effect in relation to GnRH receptor that makes them applicable for treatment of GnRH-related diseases, particularly prostate cancer, benign prostatic hyperplasia, breast cancer, endometriosis and/or uterine fibroid tumour.
EFFECT: improved clinical effectiveness.
11 cl, 70 tbl, 765 ex
SUBSTANCE: invention refers to medical equipment, namely to apparatuses for human body exposure to electric current. The apparatus comprises a square pulse generator 1, an electronic waveform memory unit 3, a comparator 2 and terminal electrodes 6 connected to its output stage 5. An input of the comparator 2 is connected to the square pulse generator 1 and to the electronic waveform memory unit 3. In addition, the apparatus comprises an electric pulse counter 4 connected to the input of the comparator 2, and the electronic waveform memory unit 3 contains the preset parametres of relative electric pulse duration of derived by reduction of rhythmocardiograms of practically healthy people with recovering respiratory wave period and heart rate therefrom.
EFFECT: use of the invention allows enhancing the apparatus due to correction of the functional state of a human body by electric pulse action.
SUBSTANCE: invention refers to medicine, aims at electrical myostimulation and can be used for development of power qualities and muscle endurance, correction of body composition. Performing the procedures involve multichannel exposure on various grounds of muscles by multiple stimulations K within 1 to 10 of acoustical frequency currents, variable sinusoidal current of frequency 2200-2500 Hz and amplitude modulation of frequency 40-70 Hz. The exposure is continuous and includes pulse chains t of duration to time ratio T: t/T=1/n, where 1≤n≤5 is an integer.
EFFECT: enhanced and more effective electrical myostimulation.
FIELD: medicine, veterinary science.
SUBSTANCE: method involves single three-staged exposure to a pulse rectangular electric current for 10 minutes: 300 Hz for 2 min, 500 Hz for 3 min, 700 Hz for 5 min at constant pulse duration 0.5 ms with increasing current 10 mA in the beginning to 50 mA in the end. It is followed with oral introduction of a fodder additive - alkaline hydrolyzate sapropel in dosage 15 mg/kg of body weight a day combined with feeding milk twice a day during one therapeutic course of 15 days.
EFFECT: method allows improving clinical effectiveness and prevention of anaemia with increasing weight gains.
SUBSTANCE: invention refers to medicine and aims at treating visual impairments following brain tumour extraction. It involves photostimulation at frequency modes 4-35 Hz, the most typical rhythms of bioelectric brain activity. The encephalogram shows adoption of presented flicker rate in the involved and intact cerebral hemispheres. It is followed with combined light and electric stimulation of the afferent input of the involved cerebral hemispheres in the frequency range 4-9 Hz, and of the intact cerebral hemisphere in the frequency range 10-35 Hz. Frequency variation of the flicker adoption is controlled to correct the exposure modes. The therapeutic course is 10-15 sessions.
EFFECT: method allows prescribing the adequate frequency modes capable to cause brain response.
2 cl, 2 ex, 4 dwg
SUBSTANCE: invention refers to ophthalmology, and aims at treating dystrophic ophthalmopathies. Gel "Lamifaren" is prescribed in an oral dose 20 g once a day, 30 minutes before a meal. Additionally, "Selzinc" is prescribed in an oral dose 1 tablet; 30 minutes later, lateral galvanisation follows. Two anode electrodes are glued within the orbits, while the third cathode electrode - within the forehead on the midline, closer to the bridge of nose. Duration of galvanisation is 10 minutes, at current strength 1 mA. Number of procedures is 10. Then during three months, 20 g of gel "Lamifaren" and one tablet of "Selzinc" are administered daily. Said therapy is carried out every 2 months.
EFFECT: method allows improving the level of oxidation-reduction reactions, stimulating metabolic processes and stabilising cell membranes.
3 ex, 1 tbl
SUBSTANCE: invention concerns medicine, namely the methods of treating neurodegenerative diseases, and used for treating Parkinson's disease. With underlying pharmacotherapy, cerebral structure involving forehead and occiput is exposed to pulse current specifically balanced bi-phase current comprising dual burst of frequency 70-90 Hz for 20-40 minutes a day during 15 days.
EFFECT: higher clinical effectiveness with respect to Parkinson's disease that is ensured by reduced manifestation of psychoemotional injuries, elimination of antidepressants and anxiolytics that reduces possibility of by-effects of pharmacotherapy.
1 dwg, 3 ex
SUBSTANCE: electrodes contain active intratumoral, intrascleral and extrascleral parts. Flexible electric wire for connection to apparatus of electro-chemical lysis ECL is rigidly fastened to free end of extrascleral part. Electrodes have circular milling on whole length of intascleral part 0.1 mm deep, which is filled with bioinert electroinsulating material. Method of electrode introduction consists in the fact that electrodes are introduced in neoplasm under ultrasonic control transsclerally: in center of tumor base; on line of largest base diametre from its both ends, indenting 1.5 mm from edges of tumor base from each end. Central electrode is introduced perpendicularly to sclera, not reaching 1.0 mm to tumor top, and peripheral electrodes - angularly to sclera in such way, that end of electrode peak is at distance 1.0 mm from tumor peak and 1.5 mm from its lateral surface.
EFFECT: claimed group of inventions ensures minimal damage to structures and tissues of eye during introduction of electrodes, absence of necessity of additional surgical manipulations after finishing ECL, formation of necrosis zone in whole tumor volume in absence of injury to surrounding structures and tissues of eye.
4 cl, 2 ex
SUBSTANCE: invention concerns medicine, particularly traumatology, and is intended for emergency care, therapy and rehabilitation in locomotor system injury cases. Treatment method allows for painless, most efficient and fast therapy using body self-adjustment mechanisms and activating immune system. Definite spots on wrists and feet correlated to the injury by Su Jok, and direct projection of the injury are exposed to low-frequency currents, beginning by impulse frequency of 77 Hz or under applied simultaneously to area corresponding to immune system - thumb and index finger junction area at palm back - and to direct injury projection area for 2-3 days each 2-3. Further the current of 10 Hz or lower frequency is applied to correlated areas by Su Jok system. Power level of impulse effect is selected individually by acceptable or by threshold sensitivity, session duration is defined by skin impedance change. Additionally the same action is applied to the mirror body area corresponding to injury. For pelvic and leg bone injury, lumbosacral area is additionally exposed.
EFFECT: invention can be used for damaged bones and soft tissues of arms, additionally cervical collar area is exposed, and Bonavtilin cream is applied before and after procedures.
5 cl, 1 tbl, 3 ex
SUBSTANCE: invention relates to ophthalmology and can be used for treatment of anterior uveitis. Subconjunctival injection of medication is made above one of main anterior ciliar arteries. Above said artery active electrode is installed for performing electrophoresis. Before injection sodium fluorescein is added to medication in order to give solution ellowish-brown colour. Control of medication inflow into blood stream is realised by means of performed during electrophoresis biomicroscopy with installed on slit lamp light filters for fluorescent angiography.
EFFECT: directed inflow of medication into blood stream as well as maximal saturation of iris with medication.
SUBSTANCE: electrodes are L-shaped with active vertical part, length of which is selected depending on tumor prominence, and auxiliary horizontal part, to free end of which flexible electric wire is rigidly fixed for connection to device for electrochemical lysis (ECL). Electric wire, horizontal part and the following 2 mm of electrode vertical part are coated by insulating material. Method for insertion of electrodes for electrochemical destruction of intraocular tumors consists in transscleral insertion of electrodes in tumor by means of spear with adjustable length and cannulas 25 G perpendicularly to sclera on the line of largest diameter of base at the distance of 2.5-3.5 mm in both sides from center of tumor base at a certain depth. Depth is determined according to data of preliminary ultrasonic examination: tumor height at the distance of 2.5-3.5 mm by sclera from center of tumor base minus 1.5-2 mm.
EFFECT: minimum damage of eye structures and tissues during insertion of electrodes and performance of ECL, no necessity to perform additional surgical manipulations on completion of ECL, limitation of destruction by tumor volume.
5 cl, 2 ex
SUBSTANCE: invention relates to medicine, namely to gynaecology, and may be used for treatment of benign diseases of uterine neck. For this purpose after basis therapy with radio wave method of treatment, from the first days the female patients use hormonal therapy with single-phase contraceptives.
EFFECT: invention makes it possible to reduce time of postoperational wound epithelisation and to reduce frequency of uterine neck diseases relapses.